Detail Information of Exogenous Modulation

General Information of Drug Transporter (DT)
DT ID DTD0350 Transporter Info
Gene Name SLC39A9
Transporter Name Zinc transporter ZIP9
Gene ID
55334
UniProt ID
Q9NUM3
Exogenous factors (drugs, dietary constituents, etc.) Modulation of This DT (EGM)

Chemical Compound

  DT Modulation1

 Zinc Acetate co-treated with motexafin gadolinium results in increased expression of SLC39A9 mRNA [1]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation1

 Valproic Acid affects the expression of SLC39A9 mRNA [25]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation1

 SLC39A9 protein results in increased transport of Zinc [26]

Regulation Mechanism

 Transcription Factor Info

  3',5'-dichloro-2-hydroxy-2-methylbut-3-enanilide

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 3',5'-dichloro-2-hydroxy-2-methylbut-3-enanilide inhibits the reaction Testosterone binds to SLC39A9 protein [15]

Regulation Mechanism

 Transcription Factor Info

  4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid results in decreased expression of SLC39A9 mRNA [16]

Regulation Mechanism

 Transcription Factor Info

  Acrolein

            2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone results in increased expression of SLC39A9 mRNA [17]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation2

 Air Pollutants results in increased abundance of Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone which results in increased expression of SLC39A9 mRNA [17]

Regulation Mechanism

 Transcription Factor Info

  alpha-pinene

            2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone results in increased expression of SLC39A9 mRNA [17]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation2

 Air Pollutants results in increased abundance of Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone which results in increased expression of SLC39A9 mRNA [17]

Regulation Mechanism

 Transcription Factor Info

  beta-lapachone

            2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 beta-lapachone results in decreased expression of SLC39A9 mRNA [19]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation2

 beta-lapachone results in increased expression of SLC39A9 mRNA [19]

Regulation Mechanism

 Transcription Factor Info

  Cadmium Chloride

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Cadmium Chloride results in increased expression of SLC39A9 mRNA [20]

Regulation Mechanism

 Transcription Factor Info

  di-n-butylphosphoric acid

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 di-n-butylphosphoric acid affects the expression of SLC39A9 mRNA [21]

Regulation Mechanism

 Transcription Factor Info

  K 7174

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 K 7174 results in increased expression of SLC39A9 mRNA [12]

Regulation Mechanism

 Transcription Factor Info

  Lactic Acid

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Lactic Acid results in decreased expression of SLC39A9 mRNA [14]

Regulation Mechanism

 Transcription Factor Info

  methacrylaldehyde

            2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone results in increased expression of SLC39A9 mRNA [17]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation2

 Air Pollutants results in increased abundance of Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone which results in increased expression of SLC39A9 mRNA [17]

Regulation Mechanism

 Transcription Factor Info

  motexafin gadolinium

            2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 motexafin gadolinium results in increased expression of SLC39A9 mRNA [1]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation2

 Zinc Acetate co-treated with motexafin gadolinium results in increased expression of SLC39A9 mRNA [1]

Regulation Mechanism

 Transcription Factor Info

  Ozone

            3 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone results in increased expression of SLC39A9 mRNA [17]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation2

 Air Pollutants results in increased abundance of Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone which results in increased expression of SLC39A9 mRNA [17]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation3

 Volatile Organic Compounds co-treated with Ozone results in increased expression of SLC39A9 mRNA [17]

Regulation Mechanism

 Transcription Factor Info

  prochloraz

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 prochloraz inhibits the reaction Testosterone binds to SLC39A9 protein [15]

Regulation Mechanism

 Transcription Factor Info

  sodium arsenite

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 sodium arsenite results in increased expression of SLC39A9 mRNA [20]

Regulation Mechanism

 Transcription Factor Info

  Sodium Selenite

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Sodium Selenite results in increased expression of SLC39A9 mRNA [24]

Regulation Mechanism

 Transcription Factor Info

  Testosterone

            4 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 3',5'-dichloro-2-hydroxy-2-methylbut-3-enanilide inhibits the reaction Testosterone binds to SLC39A9 protein [15]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation2

 prochloraz inhibits the reaction Testosterone binds to SLC39A9 protein [15]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation3

 Testosterone binds to SLC39A9 protein [15]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation4

 vinclozolin inhibits the reaction Testosterone binds to SLC39A9 protein [15]

Regulation Mechanism

 Transcription Factor Info

  vinclozolin

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 vinclozolin inhibits the reaction Testosterone binds to SLC39A9 protein [15]

Regulation Mechanism

 Transcription Factor Info

Mycotoxins

  ochratoxin A

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 ochratoxin A results in decreased expression of SLC39A9 mRNA [9]

Regulation Mechanism

 Transcription Factor Info

Approved Drug

  Zinc Acetate

            2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Zinc Acetate increases the expression of SLC39A9 [1]

  Theophylline

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Theophylline increases the expression of SLC39A9 [2]

  Hydrogen Peroxide

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Hydrogen Peroxide affects the expression of SLC39A9 [3]

  Calcitriol

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Calcitriol inhibits the expression of SLC39A9 [4]

  Zidovudine

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Zidovudine increases the expression of SLC39A9 [5]

  Doxorubicin

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Doxorubicin inhibits the expression of SLC39A9 [6]

  Valproic Acid

            2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Valproic Acid increases the expression of SLC39A9 [7]

Drug in Phase 2 Trial

  Motexafin gadolinium

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Motexafin gadolinium increases the expression of SLC39A9 [1]

Investigative Drug

  Milchsaure

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Milchsaure inhibits the expression of SLC39A9 [14]

Patented Pharmaceutical Agent

  K-7174

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 K-7174 increases the expression of SLC39A9 [12]

Natural Product

  Particulate Matter

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Particulate Matter inhibits the expression of SLC39A9 [13]

  Resveratrol

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Plant Extracts co-treated with Resveratrol results in increased expression of SLC39A9 mRNA [23]

Regulation Mechanism

 Transcription Factor Info

Plant Extract

  Grape Seed Proanthocyanidins

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Grape Seed Proanthocyanidins increases the expression of SLC39A9 [11]

Environmental toxicant

  Zinc

            2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Zinc inhibits the expression of SLC39A9 [8]

  Lead

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Lead results in increased expression of SLC39A9 mRNA [22]

Regulation Mechanism

 Transcription Factor Info

Acute Toxic Substance

  Ochratoxin A

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Ochratoxin A inhibits the expression of SLC39A9 [9]

Carcinogen

  Benzo(a)pyrene

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Benzo(a)pyrene increases the expression of SLC39A9 [10]

  Arsenic

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Arsenic affects the methylation of SLC39A9 gene [18]

Regulation Mechanism

 Transcription Factor Info
References
1 Motexafin gadolinium and zinc induce oxidative stress responses and apoptosis in B-cell lymphoma lines. Cancer Res. 2005 Dec 15;65(24):11676-88.
2 Oxidative stress modulates theophylline effects on steroid responsiveness. Biochem Biophys Res Commun. 2008 Dec 19;377(3):797-802.
3 Global gene expression analysis reveals differences in cellular responses to hydroxyl- and superoxide anion radical-induced oxidative stress in caco-2 cells. Toxicol Sci. 2010 Apr;114(2):193-203.
4 Cellular zinc homeostasis is a regulator in monocyte differentiation of HL-60 cells by 1 alpha,25-dihydroxyvitamin D3. J Leukoc Biol. 2010 May;87(5):833-44.
5 Differential gene expression in human hepatocyte cell lines exposed to the antiretroviral agent zidovudine. Arch Toxicol. 2014 Mar;88(3):609-23.
6 Bringing in vitro analysis closer to in vivo: Studying doxorubicin toxicity and associated mechanisms in 3D human microtissues with PBPK-based dose modelling. Toxicol Lett. 2018 Sep 15;294:184-192.
7 Stem Cell Transcriptome Responses and Corresponding Biomarkers That Indicate the Transition from Adaptive Responses to Cytotoxicity. Chem Res Toxicol. 2017 Apr 17;30(4):905-922.
8 Profiling of zinc-altered gene expression in human prostate normal vs. cancer cells: a time course study. J Nutr Biochem. 2009 Dec;20(12):1000-12.
9 Intracellular zinc stores protect the intestinal epithelium from Ochratoxin A toxicity. Toxicol In Vitro. 2009 Dec;23(8):1516-21.
10 Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
11 Dietary catechins and procyanidins modulate zinc homeostasis in human HepG2 cells. J Nutr Biochem. 2011 Feb;22(2):153-63.
12 A low-molecular-weight compound K7174 represses hepcidin: possible therapeutic strategy against anemia of chronic disease. PLoS One. 2013 Sep 27;8(9):e75568.
13 Diesel exhaust particulate associated chemicals attenuate expression of CXCL10 in human primary bronchial epithelial cells. Toxicol In Vitro. 2017 Dec;45(Pt 3):409-416.
14 Transcriptional profiling of lactic acid treated reconstructed human epidermis reveals pathways underlying stinging and itch. Toxicol In Vitro. 2019 Jun;57:164-173.
15 Novel mechanism of endocrine disruption by fungicides through binding to the membrane androgen receptor, ZIP9 (SLC39A9), and antagonizing rapid testosterone induction of the intrinsic apoptotic pathway. Steroids. 2019;149:108415.
16 Altering cancer transcriptomes using epigenomic inhibitors. Epigenetics Chromatin. 2015 Feb 24;8:9.
17 Post-transcriptional air pollution oxidation to the cholesterol biosynthesis pathway promotes pulmonary stress phenotypes. Commun Biol. 2020;3(1):392.
18 Prenatal arsenic exposure and the epigenome: identifying sites of 5-methylcytosine alterations that predict functional changes in gene expression in newborn cord blood and subsequent birth outcomes. Toxicol Sci. 2015 Jan;143(1):97-106.
19 Lapachone induces ferroptosis of colorectal cancer cells via NCOA4-mediated ferritinophagy by activating JNK pathway. Chem Biol Interact. 2024;389:110866.
20 High-Throughput Transcriptomics of Nontumorigenic Breast Cells Exposed to Environmentally Relevant Chemicals. Environ Health Perspect. 2024;132(4):47002.
21 Association between Organophosphate Ester Exposure and Insulin Resistance with Glycometabolic Disorders among Older Chinese Adults 60-69 Years of Age: Evidence from the China BAPE Study. Environ Health Perspect. 2023;131(4):47009.
22 Screening autism-associated environmental factors in differentiating human neural progenitors with fractional factorial design-based transcriptomics. Sci Rep. 2023;13(1):10519.
23 One-year supplementation with a grape extract containing resveratrol modulates inflammatory-related microRNAs and cytokines expression in peripheral blood mononuclear cells of type 2 diabetes and hypertensive patients with coronary artery disease. Pharmacol Res. 2013;72:69-82.
24 Supplementation of healthy volunteers with nutritionally relevant amounts of selenium increases the expression of lymphocyte protein biosynthesis genes. Am J Clin Nutr. 2008;87(1):181-9.
25 Gene Expression Regulation and Pathway Analysis After Valproic Acid and Carbamazepine Exposure in a Human Embryonic Stem Cell-Based Neurodevelopmental Toxicity Assay. Toxicol Sci. 2015 Aug;146(2):311-20.
26 Expression of ZnT and ZIP zinc transporters in the human RPE and their regulation by neurotrophic factors. Invest Ophthalmol Vis Sci. 2008;49(3):1221-31.

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