Detail Information of Exogenous Modulation

General Information of Drug Transporter (DT)
DT ID DTD0348 Transporter Info
Gene Name SLC39A7
Transporter Name Zinc transporter SLC39A7
Gene ID
7922
UniProt ID
Q92504
Exogenous factors (drugs, dietary constituents, etc.) Modulation of This DT (EGM)

Chemical Compound

  DT Modulation1

 2-dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole inhibits the reaction Zinc co-treated with pyrithione promotes the reaction CSNK2A1 protein binds to SLC39A7 protein [13]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation2

 2-dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole inhibits the reaction Zinc results in increased phosphorylation of SLC39A7 protein [13]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation3

 4,5,6,7-tetrabromobenzotriazole inhibits the reaction Zinc co-treated with pyrithione promotes the reaction CSNK2A1 protein binds to SLC39A7 protein [13]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation4

 SLC39A7 mutant form inhibits the reaction Zinc results in increased phosphorylation of AKT1 protein [13]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation5

 SLC39A7 protein affects the localization of Zinc [24]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation6

 SLC39A7 protein results in increased transport of Zinc [25]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation7

 Zinc co-treated with pyrithione promotes the reaction CSNK2A1 protein binds to SLC39A7 protein [13]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation8

 Zinc promotes the reaction CSNK2A1 protein binds to SLC39A7 protein [13]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation9

 Zinc results in increased phosphorylation of SLC39A7 protein [13]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation1

 Benzo(a)pyrene affects the methylation of SLC39A7 promoter [15]

Regulation Mechanism

 Transcription Factor Info

  2-dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole

            2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 2-dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole inhibits the reaction Zinc co-treated with pyrithione promotes the reaction CSNK2A1 protein binds to SLC39A7 protein [13]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation2

 2-dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole inhibits the reaction Zinc results in increased phosphorylation of SLC39A7 protein [13]

Regulation Mechanism

 Transcription Factor Info

  4,5,6,7-tetrabromobenzotriazole

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 4,5,6,7-tetrabromobenzotriazole inhibits the reaction Zinc co-treated with pyrithione promotes the reaction CSNK2A1 protein binds to SLC39A7 protein [13]

Regulation Mechanism

 Transcription Factor Info

  Amphotericin B

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Amphotericin B analog results in decreased expression of SLC39A7 mRNA [14]

Regulation Mechanism

 Transcription Factor Info

  bisphenol A

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 bisphenol A results in increased expression of SLC39A7 protein [10]

Regulation Mechanism

 Transcription Factor Info

  bisphenol AF

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 bisphenol AF results in increased expression of SLC39A7 protein [10]

Regulation Mechanism

 Transcription Factor Info

  bisphenol B

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 bisphenol B results in increased expression of SLC39A7 protein [10]

Regulation Mechanism

 Transcription Factor Info

  Cadmium Chloride

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Cadmium Chloride results in increased abundance of Cadmium which results in increased expression of SLC39A7 mRNA [16]

Regulation Mechanism

 Transcription Factor Info

  CGP 52608

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 CGP 52608 promotes the reaction RORA protein binds to SLC39A7 gene [17]

Regulation Mechanism

 Transcription Factor Info

  Cisplatin

            2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Cisplatin co-treated with Panobinostat affects the expression of SLC39A7 mRNA [18]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation2

 SLC39A7 protein affects the susceptibility to Cisplatin [19]

Regulation Mechanism

 Transcription Factor Info

  coumarin

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 coumarin results in decreased phosphorylation of SLC39A7 protein [20]

Regulation Mechanism

 Transcription Factor Info

  di-n-butylphosphoric acid

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 di-n-butylphosphoric acid affects the expression of SLC39A7 mRNA [21]

Regulation Mechanism

 Transcription Factor Info

  FR900359

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 FR900359 affects the phosphorylation of SLC39A7 protein [22]

Regulation Mechanism

 Transcription Factor Info

  Ionomycin

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Ionomycin promotes the reaction EGF protein promotes the reaction CSNK2A1 protein binds to SLC39A7 protein [13]

Regulation Mechanism

 Transcription Factor Info

  Panobinostat

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Cisplatin co-treated with Panobinostat affects the expression of SLC39A7 mRNA [18]

Regulation Mechanism

 Transcription Factor Info

  pirinixic acid

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 pirinixic acid binds to and results in increased activity of PPARA protein which results in increased expression of SLC39A7 mRNA [23]

Regulation Mechanism

 Transcription Factor Info

  pyrithione

            3 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 2-dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole inhibits the reaction Zinc co-treated with pyrithione promotes the reaction CSNK2A1 protein binds to SLC39A7 protein [13]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation2

 4,5,6,7-tetrabromobenzotriazole inhibits the reaction Zinc co-treated with pyrithione promotes the reaction CSNK2A1 protein binds to SLC39A7 protein [13]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation3

 Zinc co-treated with pyrithione promotes the reaction CSNK2A1 protein binds to SLC39A7 protein [13]

Regulation Mechanism

 Transcription Factor Info

  Selenium

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Selenium results in increased expression of SLC39A7 mRNA [3]

Regulation Mechanism

 Transcription Factor Info

  trichostatin A

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 trichostatin A affects the expression of SLC39A7 mRNA [7]

Regulation Mechanism

 Transcription Factor Info

  triphenyl phosphate

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 triphenyl phosphate affects the expression of SLC39A7 mRNA [21]

Regulation Mechanism

 Transcription Factor Info

Mycotoxins

  ochratoxin A

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 ochratoxin A results in decreased expression of SLC39A7 mRNA [4]

Regulation Mechanism

 Transcription Factor Info

Approved Drug

  Cyclosporine

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Cyclosporine increases the expression of SLC39A7 [1]

  Cannabidiol

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Cannabidiol increases the expression of SLC39A7 [2]

Drug in Phase 2 Trial

  Bisphenol A

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Bisphenol A increases the expression of SLC39A7 [10]

  Bisphenol B

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Bisphenol B increases the expression of SLC39A7 [10]

Drug in Phase 1 Trial

  Trichostatin A

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Trichostatin A affects the expression of SLC39A7 [7]

  Dihydrotestosterone

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Dihydrotestosterone increases the expression of SLC39A7 [8]

Investigative Drug

  NVS-ZP7-4

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 NVS-ZP7-4 inhibits the activity of SLC39A7 [12]

Natural Product

  Selenium nanoparticles

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Selenium nanoparticles increases the expression of SLC39A7 [3]

  Tobacco Smoke Pollution

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Tobacco Smoke Pollution increases the expression of SLC39A7 [9]

Plant Extract

  Grape Seed Proanthocyanidins

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Grape Seed Proanthocyanidins inhibits the expression of SLC39A7 [5]

Environmental toxicant

  Zinc

          10 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Zinc inhibits the expression of SLC39A7 [4]

Acute Toxic Substance

  Ochratoxin A

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Ochratoxin A inhibits the expression of SLC39A7 [4]

Carcinogen

  Benzo(a)pyrene

            2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Benzo(a)pyrene inhibits the expression of SLC39A7 [11]

  Cadmium

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Cadmium Chloride results in increased abundance of Cadmium which results in increased expression of SLC39A7 mRNA [16]

Regulation Mechanism

 Transcription Factor Info

Herbicide

  Atrazine

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Atrazine increases the expression of SLC39A7 [6]
References
1 Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
2 Cannabidiol induces antioxidant pathways in keratinocytes by targeting BACH1. Redox Biol. 2020 Jan;28:101321.
3 Selenium and vitamin E: cell type- and intervention-specific tissue effects in prostate cancer. J Natl Cancer Inst. 2009 Mar 4;101(5):306-20.
4 Intracellular zinc stores protect the intestinal epithelium from Ochratoxin A toxicity. Toxicol In Vitro. 2009 Dec;23(8):1516-21.
5 Dietary catechins and procyanidins modulate zinc homeostasis in human HepG2 cells. J Nutr Biochem. 2011 Feb;22(2):153-63.
6 Endoplasmic reticulum stress impairs insulin signaling through mitochondrial damage in SH-SY5Y cells. Neurosignals. 2012;20(4):265-80.
7 A trichostatin A expression signature identified by TempO-Seq targeted whole transcriptome profiling. PLoS One. 2017 May 25;12(5):e0178302.
8 LSD1 activates a lethal prostate cancer gene network independently of its demethylase function. Proc Natl Acad Sci U S A. 2018 May 1;115(18):E4179-E4188.
9 Integration of transcriptome analysis with pathophysiological endpoints to evaluate cigarette smoke toxicity in an in vitro human airway tissue model. Arch Toxicol. 2021 May;95(5):1739-1761.
10 Alternatives for the worse: Molecular insights into adverse effects of bisphenol a and substitutes during human adipocyte differentiation. Environ Int. 2021 Nov;156:106730.
11 Benzo[a]pyrene-induced changes in microRNA-mRNA networks. Chem Res Toxicol. 2012 Apr 16;25(4):838-49.
12 Discovery of a ZIP7 inhibitor from a Notch pathway screen. Nat Chem Biol. 2019 Feb;15(2):179-188.
13 Protein kinase CK2 triggers cytosolic zinc signaling pathways by phosphorylation of zinc channel ZIP7. Sci Signal. 2012;5(210):ra11.
14 Differential expression of microRNAs and their predicted targets in renal cells exposed to amphotericin B and its complex with copper (II) ions. Toxicol Mech Methods. 2017;27(7):537-543.
15 Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017;8(1):1369-1391.
16 Cadmium acute exposure induces metabolic and transcriptomic perturbations in human mature adipocytes. Toxicology. 2022;470:153153.
17 Identification of potential target genes of ROR-alpha in THP1 and HUVEC cell lines. Exp Cell Res. 2017;353(1):6-15.
18 Low-dose LBH589 increases the sensitivity of cisplatin to cisplatin-resistant ovarian cancer cells. Taiwan J Obstet Gynecol. 2011;50(2):165-71.
19 Gene expression profiling of 30 cancer cell lines predicts resistance towards 11 anticancer drugs at clinically achieved concentrations. Int J Cancer. 2006;118(7):1699-712.
20 Quantitative phosphoproteomics reveal cellular responses from caffeine, coumarin and quercetin in treated HepG2 cells. Toxicol Appl Pharmacol. 2022;449:116110.
21 Association between Organophosphate Ester Exposure and Insulin Resistance with Glycometabolic Disorders among Older Chinese Adults 60-69 Years of Age: Evidence from the China BAPE Study. Environ Health Perspect. 2023;131(4):47009.
22 Protein Kinase Signaling Networks Driven by Oncogenic Gq/11 in Uveal Melanoma Identified by Phosphoproteomic and Bioinformatic Analyses. Mol Cell Proteomics. 2023;22(11):100649.
23 Comparative analysis of gene regulation by the transcription factor PPARalpha between mouse and human. PLoS One. 2009;4(8):e6796.
24 The ZIP7 gene (Slc39a7) encodes a zinc transporter involved in zinc homeostasis of the Golgi apparatus. J Biol Chem. 2005;280(15):15456-63.
25 Expression of ZnT and ZIP zinc transporters in the human RPE and their regulation by neurotrophic factors. Invest Ophthalmol Vis Sci. 2008;49(3):1221-31.

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