Detail Information of Exogenous Modulation

General Information of Drug Transporter (DT)
DT ID	DTD0342 Transporter Info
Gene Name	SLC39A14
Transporter Name	Zinc transporter ZIP14
Gene ID	23516
UniProt ID	Q15043

Exogenous factors (drugs, dietary constituents, etc.) Modulation of This DT (EGM)
Chemical Compound
DT Modulation1	Zinc Acetate co-treated with motexafin gadolinium affects the expression of SLC39A14 mRNA		[2]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Cyclosporine results in increased expression of SLC39A14 mRNA		[41]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Estradiol co-treated with Progesterone results in increased expression of SLC39A14 mRNA		[46]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC39A14 mRNA		[26]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Valproic Acid results in decreased methylation of SLC39A14 gene		[61]
Regulation Mechanism			Transcription Factor Info
1-Methyl-4-phenylpyridinium	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	1-Methyl-4-phenylpyridinium results in increased expression of SLC39A14 mRNA		[19]
Regulation Mechanism			Transcription Factor Info
2-bromopalmitate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	2-bromopalmitate inhibits the reaction Cadmium Chloride results in increased abundance of Cadmium which results in increased palmitoylation of SLC39A14 protein		[25]
Regulation Mechanism			Transcription Factor Info
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC39A14 mRNA		[26]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC39A14 mRNA		[26]
Regulation Mechanism			Transcription Factor Info
aristolochic acid I	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	aristolochic acid I results in decreased expression of SLC39A14 mRNA		[29]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	aristolochic acid I results in decreased expression of SLC39A14 protein		[29]
Regulation Mechanism			Transcription Factor Info
Benzo(a)pyrene	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Benzo(a)pyrene affects the methylation of SLC39A14 5' UTR		[31]
Regulation Mechanism			Transcription Factor Info
benzo(e)pyrene	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	benzo(e)pyrene results in decreased methylation of SLC39A14 intron		[28]
Regulation Mechanism			Transcription Factor Info
beta-methylcholine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	beta-methylcholine affects the expression of SLC39A14 mRNA		[32]
Regulation Mechanism			Transcription Factor Info
beta-Naphthoflavone	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	beta-Naphthoflavone results in decreased expression of SLC39A14 protein		[33]
Regulation Mechanism			Transcription Factor Info
bisphenol A	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	bisphenol A results in decreased expression of SLC39A14 protein		[34]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	bisphenol A results in decreased methylation of SLC39A14 gene		[35]
Regulation Mechanism			Transcription Factor Info
bisphenol S	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	bisphenol S results in decreased methylation of SLC39A14 gene		[35]
Regulation Mechanism			Transcription Factor Info
Cadmium Chloride	4 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	2-bromopalmitate inhibits the reaction Cadmium Chloride results in increased abundance of Cadmium which results in increased palmitoylation of SLC39A14 protein		[25]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Cadmium Chloride results in decreased expression of SLC39A14 protein		[38]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	Cadmium Chloride results in increased abundance of Cadmium which results in increased expression of SLC39A14 mRNA		[36]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	Cadmium Chloride results in increased abundance of Cadmium which results in increased palmitoylation of SLC39A14 protein		[25]
Regulation Mechanism			Transcription Factor Info
cobaltous chloride	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	cobaltous chloride results in decreased expression of SLC39A14 mRNA		[39]
Regulation Mechanism			Transcription Factor Info
coumarin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	coumarin results in increased phosphorylation of SLC39A14 protein		[40]
Regulation Mechanism			Transcription Factor Info
Dichlorodiphenyl Dichloroethylene	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Dichlorodiphenyl Dichloroethylene results in decreased expression of SLC39A14 mRNA		[42]
Regulation Mechanism			Transcription Factor Info
Dicyclohexylcarbodiimide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	SLC39A14 gene SNP affects the susceptibility to Dicyclohexylcarbodiimide		[43]
Regulation Mechanism			Transcription Factor Info
di-n-butylphosphoric acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	di-n-butylphosphoric acid affects the expression of SLC39A14 mRNA		[44]
Regulation Mechanism			Transcription Factor Info
Diquat	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Diquat results in increased expression of SLC39A14 protein		[45]
Regulation Mechanism			Transcription Factor Info
dorsomorphin	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC39A14 mRNA		[26]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC39A14 mRNA		[26]
Regulation Mechanism			Transcription Factor Info
entinostat	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	entinostat results in increased expression of SLC39A14 mRNA		[20]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC39A14 mRNA		[26]
Regulation Mechanism			Transcription Factor Info
epigallocatechin gallate	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	epigallocatechin gallate inhibits the reaction IL6 protein results in increased expression of SLC39A14 mRNA		[17]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	epigallocatechin gallate results in increased expression of SLC39A14 mRNA		[1]
Regulation Mechanism			Transcription Factor Info
FR900359	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	FR900359 results in decreased phosphorylation of SLC39A14 protein		[47]
Regulation Mechanism			Transcription Factor Info
Isoniazid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Isoniazid results in decreased expression of SLC39A14 protein		[48]
Regulation Mechanism			Transcription Factor Info
Manganese	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	SLC39A14 protein affects the uptake of Manganese		[49]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	SLC39A14 protein results in increased import of and results in increased secretion of Manganese		[50]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	sodium arsenite results in increased abundance of Arsenic co-treated with manganese chloride results in increased abundance of Manganese results in increased expression of SLC39A14 mRNA		[30]
Regulation Mechanism			Transcription Factor Info
manganese chloride	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	sodium arsenite results in increased abundance of Arsenic co-treated with manganese chloride results in increased abundance of Manganese results in increased expression of SLC39A14 mRNA		[30]
Regulation Mechanism			Transcription Factor Info
Methapyrilene	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Methapyrilene results in decreased methylation of SLC39A14 intron		[28]
Regulation Mechanism			Transcription Factor Info
methylmercuric chloride	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	methylmercuric chloride results in decreased expression of SLC39A14 mRNA		[51]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	methylmercuric chloride results in increased expression of SLC39A14 mRNA		[16]
Regulation Mechanism			Transcription Factor Info
Methyl Methanesulfonate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Methyl Methanesulfonate results in decreased expression of SLC39A14 mRNA		[52]
Regulation Mechanism			Transcription Factor Info
motexafin gadolinium	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	motexafin gadolinium results in increased expression of SLC39A14 mRNA		[2]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Zinc Acetate co-treated with motexafin gadolinium affects the expression of SLC39A14 mRNA		[2]
Regulation Mechanism			Transcription Factor Info
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	ochratoxin A co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of SLC39A14 mRNA		[54]
Regulation Mechanism			Transcription Factor Info
Okadaic Acid	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Okadaic Acid results in decreased expression of SLC39A14 mRNA		[55]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Okadaic Acid results in decreased expression of SLC39A14 protein		[55]
Regulation Mechanism			Transcription Factor Info
Progesterone	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Estradiol co-treated with Progesterone results in increased expression of SLC39A14 mRNA		[46]
Regulation Mechanism			Transcription Factor Info
S-(1,2-dichlorovinyl)cysteine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	S-(1,2-dichlorovinyl)cysteine inhibits the reaction Lipopolysaccharides results in increased expression of SLC39A14 mRNA		[56]
Regulation Mechanism			Transcription Factor Info
Silicon Dioxide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Silicon Dioxide analog results in increased expression of SLC39A14 mRNA		[57]
Regulation Mechanism			Transcription Factor Info
sodium arsenite	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	sodium arsenite results in decreased expression of SLC39A14 mRNA		[58]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	sodium arsenite results in increased abundance of Arsenic co-treated with manganese chloride results in increased abundance of Manganese results in increased expression of SLC39A14 mRNA		[30]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	sodium arsenite results in increased abundance of Arsenic which results in increased expression of SLC39A14 mRNA		[30]
Regulation Mechanism			Transcription Factor Info
tert-Butylhydroperoxide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	tert-Butylhydroperoxide results in increased expression of SLC39A14 mRNA		[59]
Regulation Mechanism			Transcription Factor Info
Thiram	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Thiram results in decreased expression of SLC39A14 mRNA		[42]
Regulation Mechanism			Transcription Factor Info
triphenyl phosphate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	triphenyl phosphate affects the expression of SLC39A14 mRNA		[44]
Regulation Mechanism			Transcription Factor Info
tris(2-butoxyethyl) phosphate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	tris(2-butoxyethyl) phosphate affects the expression of SLC39A14 mRNA		[60]
Regulation Mechanism			Transcription Factor Info
Vitamin K 3	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Vitamin K 3 affects the expression of SLC39A14 mRNA		[5]
Regulation Mechanism			Transcription Factor Info
Zinc	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	SLC39A14 protein results in increased transport of Zinc		[62]
Regulation Mechanism			Transcription Factor Info
Mycotoxins
Aflatoxin B1	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Aflatoxin B1 results in decreased methylation of SLC39A14 gene		[27]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Aflatoxin B1 results in decreased methylation of SLC39A14 intron		[28]
Regulation Mechanism			Transcription Factor Info
aflatoxin B2	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	aflatoxin B2 results in decreased methylation of SLC39A14 intron		[28]
Regulation Mechanism			Transcription Factor Info
ochratoxin A	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	ochratoxin A co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of SLC39A14 mRNA		[54]
Regulation Mechanism			Transcription Factor Info
Carcinogen
Arsenic	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	sodium arsenite results in increased abundance of Arsenic co-treated with manganese chloride results in increased abundance of Manganese results in increased expression of SLC39A14 mRNA		[30]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	sodium arsenite results in increased abundance of Arsenic which results in increased expression of SLC39A14 mRNA		[30]
Regulation Mechanism			Transcription Factor Info
Cadmium	4 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	2-bromopalmitate inhibits the reaction Cadmium Chloride results in increased abundance of Cadmium which results in increased palmitoylation of SLC39A14 protein		[25]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Cadmium Chloride results in increased abundance of Cadmium which results in increased expression of SLC39A14 mRNA		[36]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	Cadmium Chloride results in increased abundance of Cadmium which results in increased palmitoylation of SLC39A14 protein		[25]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	SLC39A14 protein affects the uptake of Cadmium		[37]
Regulation Mechanism			Transcription Factor Info
Nickel	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Nickel results in increased expression of SLC39A14 mRNA		[53]
Regulation Mechanism			Transcription Factor Info
Approved Drug
Acetylcysteine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Acetylcysteine increases the expression of SLC39A14		[1]
Zinc Acetate	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Zinc Acetate increases the expression of SLC39A14		[2]
Copper Sulfate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Copper Sulfate inhibits the expression of SLC39A14		[3]
Cisplatin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Cisplatin increases the expression of SLC39A14		[4]
Menadione	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Menadione affects the expression of SLC39A14		[5]
Calcitriol	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Calcitriol inhibits the expression of SLC39A14		[6]
Isotretinoin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Isotretinoin increases the expression of SLC39A14		[7]
Acetaminophen	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Acetaminophen inhibits the expression of SLC39A14		[8]
Zidovudine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Zidovudine inhibits the expression of SLC39A14		[9]
Cyclosporine	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Cyclosporine inhibits the expression of SLC39A14		[10]
Cannabidiol	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Cannabidiol increases the expression of SLC39A14		[11]
Sunitinib	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Sunitinib increases the expression of SLC39A14		[12]
Tretinoin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Tretinoin inhibits the expression of SLC39A14		[13]
Dronabinol	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Dronabinol inhibits the expression of SLC39A14		[14]
Estradiol	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Estradiol increases the expression of SLC39A14		[15]
Valproic Acid	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Valproic Acid increases the expression of SLC39A14		[16]
Drug in Phase 3 Trial
Epigallocatechin gallate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Epigallocatechin gallate increases the expression of SLC39A14		[1]
Triclosan	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Triclosan inhibits the expression of SLC39A14		[22]
Drug in Phase 2 Trial
Motexafin gadolinium	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Motexafin gadolinium increases the expression of SLC39A14		[2]
MS-275	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	MS-275 increases the expression of SLC39A14		[20]
Drug in Phase 1 Trial
Quercetin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Quercetin inhibits the expression of SLC39A14		[18]
Sodium arsenite	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Sodium arsenite inhibits the expression of SLC39A14		[24]
Natural Product
Particulate Matter	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Particulate Matter inhibits the expression of SLC39A14		[21]
Tobacco Smoke Pollution	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Tobacco Smoke Pollution increases the expression of SLC39A14		[23]
Plant Extract
Grape Seed Proanthocyanidins	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Grape Seed Proanthocyanidins inhibits the expression of SLC39A14		[17]
Health and Environmental Toxicant
1-methyl-4-phenylpyridinium	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	1-methyl-4-phenylpyridinium increases the expression of SLC39A14		[19]

References
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