General Information of Drug Transporter (DT)
DT ID DTD0338 Transporter Info
Gene Name SLC39A10
Transporter Name Zinc transporter ZIP10
Gene ID
57181
UniProt ID
Q9ULF5
Exogenous factors (drugs, dietary constituents, etc.) Modulation of This DT (EGM)

Chemical Compound

  DT Modulation1

Zinc Acetate co-treated with motexafin gadolinium affects the expression of SLC39A10 mRNA [1]

Regulation Mechanism

Transcription Factor Info

  DT Modulation1

Valproic Acid affects the expression of SLC39A10 mRNA [8]

Regulation Mechanism

Transcription Factor Info

  DT Modulation2

Valproic Acid results in decreased methylation of SLC39A10 gene [56]

Regulation Mechanism

Transcription Factor Info

  DT Modulation1

Estradiol co-treated with TGFB1 protein results in increased expression of SLC39A10 mRNA [49]

Regulation Mechanism

Transcription Factor Info

  DT Modulation1

NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased expression of SLC39A10 mRNA [34]

Regulation Mechanism

Transcription Factor Info

  DT Modulation1

Benzo(a)pyrene affects the methylation of SLC39A10 promoter [40]

Regulation Mechanism

Transcription Factor Info

  4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid results in decreased expression of SLC39A10 mRNA [33]

Regulation Mechanism

Transcription Factor Info

  4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide

           2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased expression of SLC39A10 mRNA [34]

Regulation Mechanism

Transcription Factor Info

  DT Modulation2

NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased expression of SLC39A10 mRNA [34]

Regulation Mechanism

Transcription Factor Info

  4-chloro-N-((4-(1,1-dimethylethyl)phenyl)methyl)-3-ethyl-1-methyl-1H-pyrazole-5-carboxamide

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

4-chloro-N-((4-(1,1-dimethylethyl)phenyl)methyl)-3-ethyl-1-methyl-1H-pyrazole-5-carboxamide results in decreased expression of SLC39A10 mRNA [35]

Regulation Mechanism

Transcription Factor Info

  abrine

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

abrine results in decreased expression of SLC39A10 mRNA [36]

Regulation Mechanism

Transcription Factor Info

  Acrolein

           2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone results in increased oxidation of SLC39A10 mRNA [37]

Regulation Mechanism

Transcription Factor Info

  DT Modulation2

Air Pollutants results in increased abundance of Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone which results in increased oxidation of SLC39A10 mRNA [37]

Regulation Mechanism

Transcription Factor Info

  afuresertib

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

afuresertib results in decreased expression of SLC39A10 mRNA [38]

Regulation Mechanism

Transcription Factor Info

  alpha-pinene

           2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone results in increased oxidation of SLC39A10 mRNA [37]

Regulation Mechanism

Transcription Factor Info

  DT Modulation2

Air Pollutants results in increased abundance of Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone which results in increased oxidation of SLC39A10 mRNA [37]

Regulation Mechanism

Transcription Factor Info

  beta-methylcholine

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

beta-methylcholine affects the expression of SLC39A10 mRNA [41]

Regulation Mechanism

Transcription Factor Info

  bisphenol A

           2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

bisphenol A results in decreased expression of SLC39A10 mRNA [29]

Regulation Mechanism

Transcription Factor Info

  DT Modulation2

bisphenol A results in decreased expression of SLC39A10 protein [42]

Regulation Mechanism

Transcription Factor Info

  Cadmium Chloride

           2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Cadmium Chloride results in decreased expression of SLC39A10 mRNA [44]

Regulation Mechanism

Transcription Factor Info

  DT Modulation2

Cadmium Chloride results in increased abundance of Cadmium which results in decreased expression of SLC39A10 mRNA [43]

Regulation Mechanism

Transcription Factor Info

  CGP 52608

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

CGP 52608 promotes the reaction RORA protein binds to SLC39A10 gene [45]

Regulation Mechanism

Transcription Factor Info

  coumarin

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

coumarin results in increased phosphorylation of SLC39A10 protein [46]

Regulation Mechanism

Transcription Factor Info

  dicrotophos

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

dicrotophos results in decreased expression of SLC39A10 mRNA [28]

Regulation Mechanism

Transcription Factor Info

  di-n-butylphosphoric acid

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

di-n-butylphosphoric acid affects the expression of SLC39A10 mRNA [47]

Regulation Mechanism

Transcription Factor Info

  dorsomorphin

           2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased expression of SLC39A10 mRNA [34]

Regulation Mechanism

Transcription Factor Info

  DT Modulation2

NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased expression of SLC39A10 mRNA [34]

Regulation Mechanism

Transcription Factor Info

  epigallocatechin gallate

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

potassium chromate(VI) co-treated with epigallocatechin gallate results in decreased expression of SLC39A10 mRNA [48]

Regulation Mechanism

Transcription Factor Info

  FR900359

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

FR900359 affects the phosphorylation of SLC39A10 protein [50]

Regulation Mechanism

Transcription Factor Info

  gadodiamide

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

gadodiamide results in increased expression of SLC39A10 mRNA [4]

Regulation Mechanism

Transcription Factor Info

  methacrylaldehyde

           2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone results in increased oxidation of SLC39A10 mRNA [37]

Regulation Mechanism

Transcription Factor Info

  DT Modulation2

Air Pollutants results in increased abundance of Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone which results in increased oxidation of SLC39A10 mRNA [37]

Regulation Mechanism

Transcription Factor Info

  Methyl Methanesulfonate

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Methyl Methanesulfonate results in decreased expression of SLC39A10 mRNA [21]

Regulation Mechanism

Transcription Factor Info

  motexafin gadolinium

           2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

motexafin gadolinium affects the expression of SLC39A10 mRNA [1]

Regulation Mechanism

Transcription Factor Info

  DT Modulation2

Zinc Acetate co-treated with motexafin gadolinium affects the expression of SLC39A10 mRNA [1]

Regulation Mechanism

Transcription Factor Info

  N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine

           3 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

ochratoxin A co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine co-treated with Zinc results in decreased expression of SLC39A10 mRNA [51]

Regulation Mechanism

Transcription Factor Info

  DT Modulation2

ochratoxin A co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of SLC39A10 mRNA [51]

Regulation Mechanism

Transcription Factor Info

  DT Modulation3

Zinc co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of SLC39A10 mRNA [51]

Regulation Mechanism

Transcription Factor Info

  NSC 689534

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

NSC 689534 results in increased expression of SLC39A10 mRNA [20]

Regulation Mechanism

Transcription Factor Info

  Ozone

           4 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone results in increased oxidation of SLC39A10 mRNA [37]

Regulation Mechanism

Transcription Factor Info

  DT Modulation2

Air Pollutants results in increased abundance of Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone which results in increased oxidation of SLC39A10 mRNA [37]

Regulation Mechanism

Transcription Factor Info

  DT Modulation3

Air Pollutants results in increased abundance of Ozone which affects the expression of SLC39A10 mRNA [52]

Regulation Mechanism

Transcription Factor Info

  DT Modulation4

Volatile Organic Compounds co-treated with Ozone results in increased oxidation of SLC39A10 mRNA [37]

Regulation Mechanism

Transcription Factor Info

  p-Chloromercuribenzoic Acid

           2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased expression of SLC39A10 mRNA [34]

Regulation Mechanism

Transcription Factor Info

  DT Modulation2

p-Chloromercuribenzoic Acid results in decreased expression of SLC39A10 mRNA [24]

Regulation Mechanism

Transcription Factor Info

  PCI 5002

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

PCI 5002 co-treated with Zinc results in increased expression of SLC39A10 mRNA [53]

Regulation Mechanism

Transcription Factor Info

  perfluorooctane sulfonic acid

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

perfluorooctane sulfonic acid results in decreased expression of SLC39A10 mRNA [26]

Regulation Mechanism

Transcription Factor Info

  potassium chromate(VI)

           2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

potassium chromate(VI) co-treated with epigallocatechin gallate results in decreased expression of SLC39A10 mRNA [48]

Regulation Mechanism

Transcription Factor Info

  DT Modulation2

potassium chromate(VI) results in decreased expression of SLC39A10 mRNA [48]

Regulation Mechanism

Transcription Factor Info

  Rotenone

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Rotenone results in increased expression of SLC39A10 protein [54]

Regulation Mechanism

Transcription Factor Info

  Silicon Dioxide

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Silicon Dioxide analog results in increased expression of SLC39A10 mRNA [55]

Regulation Mechanism

Transcription Factor Info

  Silver

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Silver results in decreased expression of SLC39A10 mRNA [22]

Regulation Mechanism

Transcription Factor Info

  sodium arsenite

           2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

sodium arsenite results in decreased expression of SLC39A10 mRNA [44]

Regulation Mechanism

Transcription Factor Info

  DT Modulation2

sodium arsenite results in increased abundance of Arsenic which results in decreased expression of SLC39A10 mRNA [39]

Regulation Mechanism

Transcription Factor Info

  Tetrachlorodibenzodioxin

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Tetrachlorodibenzodioxin results in increased expression of SLC39A10 mRNA [18]

Regulation Mechanism

Transcription Factor Info

  triphenyl phosphate

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

triphenyl phosphate affects the expression of SLC39A10 mRNA [47]

Regulation Mechanism

Transcription Factor Info

  Zinc

           4 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

ochratoxin A co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine co-treated with Zinc results in decreased expression of SLC39A10 mRNA [51]

Regulation Mechanism

Transcription Factor Info

  DT Modulation2

PCI 5002 co-treated with Zinc results in increased expression of SLC39A10 mRNA [53]

Regulation Mechanism

Transcription Factor Info

  DT Modulation3

SLC39A10 protein results in increased transport of Zinc [57]

Regulation Mechanism

Transcription Factor Info

  DT Modulation4

Zinc co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of SLC39A10 mRNA [51]

Regulation Mechanism

Transcription Factor Info

Approved Drug

  Zinc Acetate

           2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Zinc Acetate affects the expression of SLC39A10 [1]

  Hydrogen Peroxide

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Hydrogen Peroxide affects the expression of SLC39A10 [2]

  Calcitriol

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Calcitriol inhibits the expression of SLC39A10 [3]

  Gadodiamide

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Gadodiamide increases the expression of SLC39A10 [4]

  Valproic Acid

           3 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Valproic Acid inhibits the expression of SLC39A10 [5]

  Zidovudine

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Zidovudine inhibits the expression of SLC39A10 [6]

  Zoledronic Acid

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Zoledronic Acid inhibits the expression of SLC39A10 [7]

  Carbamazepine

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Carbamazepine affects the expression of SLC39A10 [8]

  Cisplatin

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Cisplatin inhibits the expression of SLC39A10 [9]

  Arsenic Trioxide

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Arsenic Trioxide inhibits the expression of SLC39A10 [10]

  Acetaminophen

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Acetaminophen increases the expression of SLC39A10 [11]

  Doxorubicin

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Doxorubicin increases the expression of SLC39A10 [12]

  Temozolomide

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Temozolomide inhibits the expression of SLC39A10 [13]

  Ivermectin

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Ivermectin inhibits the expression of SLC39A10 [14]

  Tretinoin

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Tretinoin inhibits the expression of SLC39A10 [15]

  Estradiol

           2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Estradiol inhibits the expression of SLC39A10 [16]

  Cyclosporine

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Cyclosporine inhibits the expression of SLC39A10 [17]

Drug in Phase 2 Trial

  Motexafin gadolinium

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Motexafin gadolinium affects the expression of SLC39A10 [1]

  Bisphenol A

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Bisphenol A inhibits the expression of SLC39A10 [29]

Drug in Phase 1 Trial

  Quercetin

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Quercetin increases the expression of SLC39A10 [16]

  Dihydrotestosterone

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Dihydrotestosterone increases the expression of SLC39A10 [30]

Investigative Drug

  Phenylmercuric Acetate

           2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Phenylmercuric Acetate inhibits the expression of SLC39A10 [24]

Patented Pharmaceutical Agent

  NSC-689534

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

NSC-689534 increases the expression of SLC39A10 [20]

Natural Product

  Tobacco Smoke Pollution

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Tobacco Smoke Pollution inhibits the expression of SLC39A10 [31]

Traditional Medicine

  Jinfukang

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Jinfukang inhibits the expression of SLC39A10 [27]

Plant Extract

  Grape Seed Proanthocyanidins

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Grape Seed Proanthocyanidins increases the expression of SLC39A10 [19]

Environmental toxicant

  Polychlorinated dibenzodioxin

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Polychlorinated dibenzodioxin increases the expression of SLC39A10 [18]

Mycotoxins

  Aflatoxin B1

           2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Aflatoxin B1 increases the expression of SLC39A10 [25]

  DT Modulation2

Aflatoxin B1 affects the expression of SLC39A10 protein [18]

Regulation Mechanism

Transcription Factor Info

  ochratoxin A

           2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

ochratoxin A co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine co-treated with Zinc results in decreased expression of SLC39A10 mRNA [51]

Regulation Mechanism

Transcription Factor Info

  DT Modulation2

ochratoxin A co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of SLC39A10 mRNA [51]

Regulation Mechanism

Transcription Factor Info

Carcinogen

  Ethyl Methanesulfonate

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Ethyl Methanesulfonate inhibits the expression of SLC39A10 [21]

  Benzo(a)pyrene

           2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Benzo(a)pyrene increases the expression of SLC39A10 [32]

  Arsenic

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

sodium arsenite results in increased abundance of Arsenic which results in decreased expression of SLC39A10 mRNA [39]

Regulation Mechanism

Transcription Factor Info

  Cadmium

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Cadmium Chloride results in increased abundance of Cadmium which results in decreased expression of SLC39A10 mRNA [43]

Regulation Mechanism

Transcription Factor Info

Pesticide/Insecticide

  Dicrotophos

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Dicrotophos inhibits the expression of SLC39A10 [28]

Health and Environmental Toxicant

  tris(1,3-dichloro-2-propyl)phosphate

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

tris(1,3-dichloro-2-propyl)phosphate inhibits the expression of SLC39A10 [23]

  Perfluorooctane sulfonic acid

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Perfluorooctane sulfonic acid inhibits the expression of SLC39A10 [26]

Nanoparticle

  Silver nanoparticle

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Silver nanoparticle inhibits the expression of SLC39A10 [22]
References
1 Motexafin gadolinium and zinc induce oxidative stress responses and apoptosis in B-cell lymphoma lines. Cancer Res. 2005 Dec 15;65(24):11676-88.
2 Global gene expression analysis reveals differences in cellular responses to hydroxyl- and superoxide anion radical-induced oxidative stress in caco-2 cells. Toxicol Sci. 2010 Apr;114(2):193-203.
3 Cellular zinc homeostasis is a regulator in monocyte differentiation of HL-60 cells by 1 alpha,25-dihydroxyvitamin D3. J Leukoc Biol. 2010 May;87(5):833-44.
4 NFKappaB activation and stimulation of chemokine production in normal human macrophages by the gadolinium-based magnetic resonance contrast agent Omniscan: possible role in the pathogenesis of nephrogenic systemic fibrosis. Ann Rheum Dis. 2010 Nov;69(11):2024-33.
5 Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach. Arch Toxicol. 2013 Jan;87(1):123-43.
6 Differential gene expression in human hepatocyte cell lines exposed to the antiretroviral agent zidovudine. Arch Toxicol. 2014 Mar;88(3):609-23.
7 Interleukin-19 as a translational indicator of renal injury. Arch Toxicol. 2015 Jan;89(1):101-6.
8 Gene Expression Regulation and Pathway Analysis After Valproic Acid and Carbamazepine Exposure in a Human Embryonic Stem Cell-Based Neurodevelopmental Toxicity Assay. Toxicol Sci. 2015 Aug;146(2):311-20.
9 Low Doses of Cisplatin Induce Gene Alterations, Cell Cycle Arrest, and Apoptosis in Human Promyelocytic Leukemia Cells. Biomark Insights. 2016 Aug 24;11:113-21.
10 Gene expression profile induced by arsenic trioxide in chronic lymphocytic leukemia cells reveals a central role for heme oxygenase-1 in apoptosis and regulation of matrix metalloproteinase-9. Oncotarget. 2016 Dec 13;7(50):83359-83377.
11 Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans. Arch Toxicol. 2018 Feb;92(2):845-858.
12 Bringing in vitro analysis closer to in vivo: Studying doxorubicin toxicity and associated mechanisms in 3D human microtissues with PBPK-based dose modelling. Toxicol Lett. 2018 Sep 15;294:184-192.
13 Temozolomide induces activation of Wnt/beta-catenin signaling in glioma cells via PI3K/Akt pathway: implications in glioma therapy. Cell Biol Toxicol. 2020 Jun;36(3):273-278.
14 Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment. J Cell Physiol. 2021 Apr;236(4):2959-2975.
15 Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423.
16 Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
17 Integrative "-Omics" Analysis in Primary Human Hepatocytes Unravels Persistent Mechanisms of Cyclosporine A-Induced Cholestasis. Chem Res Toxicol. 2016 Dec 19;29(12):2164-2174.
18 Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
19 Dietary catechins and procyanidins modulate zinc homeostasis in human HepG2 cells. J Nutr Biochem. 2011 Feb;22(2):153-63.
20 A copper chelate of thiosemicarbazone NSC 689534 induces oxidative/ER stress and inhibits tumor growth in vitro and in vivo. Free Radic Biol Med. 2011 Jan 1;50(1):110-21.
21 Characterization of formaldehyde's genotoxic mode of action by gene expression analysis in TK6 cells. Arch Toxicol. 2013 Nov;87(11):1999-2012.
22 Toxicogenomic responses of human liver HepG2 cells to silver nanoparticles. J Appl Toxicol. 2015 Oct;35(10):1160-8.
23 Defensive and adverse energy-related molecular responses precede tris (1, 3-dichloro-2-propyl) phosphate cytotoxicity. J Appl Toxicol. 2016 May;36(5):649-58.
24 A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors. Arch Toxicol. 2015 Sep;89(9):1599-618.
25 Aflatoxin B1 induces persistent epigenomic effects in primary human hepatocytes associated with hepatocellular carcinoma. Toxicology. 2016 Mar 28;350-352:31-9.
26 The role of hepatocyte nuclear factor 4-alpha in perfluorooctanoic acid- and perfluorooctanesulfonic acid-induced hepatocellular dysfunction. Toxicol Appl Pharmacol. 2016 Aug 1;304:18-29.
27 Activation of AIFM2 enhances apoptosis of human lung cancer cells undergoing toxicological stress. Toxicol Lett. 2016 Sep 6;258:227-236.
28 Molecular mechanisms of discrotophos-induced toxicity in HepG2 cells: The role of CSA in oxidative stress. Food Chem Toxicol. 2017 May;103:253-260.
29 Bisphenol A induces DSB-ATM-p53 signaling leading to cell cycle arrest, senescence, autophagy, stress response, and estrogen release in human fetal lung fibroblasts. Arch Toxicol. 2018 Apr;92(4):1453-1469.
30 LSD1 activates a lethal prostate cancer gene network independently of its demethylase function. Proc Natl Acad Sci U S A. 2018 May 1;115(18):E4179-E4188.
31 Integration of transcriptome analysis with pathophysiological endpoints to evaluate cigarette smoke toxicity in an in vitro human airway tissue model. Arch Toxicol. 2021 May;95(5):1739-1761.
32 Identification of a transcriptomic signature of food-relevant genotoxins in human HepaRG hepatocarcinoma cells. Food Chem Toxicol. 2020 Jun;140:111297.
33 Altering cancer transcriptomes using epigenomic inhibitors. Epigenetics Chromatin. 2015 Feb 24;8:9.
34 Definition of transcriptome-based indices for quantitative characterization of chemically disturbed stem cell development: introduction of the STOP-Toxukn and STOP-Toxukk tests. Arch Toxicol. 2017 Feb;91(2):839-864.
35 Neurotoxicity and underlying cellular changes of 21 mitochondrial respiratory chain inhibitors. Arch Toxicol. 2021 Feb;95(2):591-615.
36 Integration of transcriptomics, proteomics and metabolomics data to reveal the biological mechanisms of abrin injury in human lung epithelial cells. Toxicol Lett. 2019;312:1-10.
37 Post-transcriptional air pollution oxidation to the cholesterol biosynthesis pathway promotes pulmonary stress phenotypes. Commun Biol. 2020;3(1):392.
38 Novel ATP-competitive Akt inhibitor afuresertib suppresses the proliferation of malignant pleural mesothelioma cells. Cancer Med. 2017;6(11):2646-2659.
39 Using transcriptomic signatures to elucidate individual and mixture effects of inorganic arsenic and manganese in human placental trophoblast HTR-8/SVneo cells. Toxicol Sci. 2025;203(2):216-226.
40 Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017;8(1):1369-1391.
41 Minimal peroxide exposure of neuronal cells induces multifaceted adaptive responses. PLoS One. 2010 Dec 17;5(12):e14352.
42 Isobaric tags for relative and absolute quantitation-based proteomics analysis of the effect of ginger oil on bisphenol A-induced breast cancer cell proliferation. Oncol Lett. 2021 Feb;21(2):101.
43 Neuronal specific and non-specific responses to cadmium possibly involved in neurodegeneration: A toxicogenomics study in a human neuronal cell model. Neurotoxicology. 2020;76:162-173.
44 High-Throughput Transcriptomics of Nontumorigenic Breast Cells Exposed to Environmentally Relevant Chemicals. Environ Health Perspect. 2024;132(4):47002.
45 Identification of potential target genes of ROR-alpha in THP1 and HUVEC cell lines. Exp Cell Res. 2017;353(1):6-15.
46 Quantitative phosphoproteomics reveal cellular responses from caffeine, coumarin and quercetin in treated HepG2 cells. Toxicol Appl Pharmacol. 2022;449:116110.
47 Association between Organophosphate Ester Exposure and Insulin Resistance with Glycometabolic Disorders among Older Chinese Adults 60-69 Years of Age: Evidence from the China BAPE Study. Environ Health Perspect. 2023;131(4):47009.
48 Epigallocatechin-3-gallate (EGCG) protects against chromate-induced toxicity in vitro. Toxicol Appl Pharmacol. 2012 Jan 15;258(2):166-75.
49 Transforming growth factor beta1 targets estrogen receptor signaling in bronchial epithelial cells. Respir Res. 2018 Aug 30;19(1):160.
50 Protein Kinase Signaling Networks Driven by Oncogenic Gq/11 in Uveal Melanoma Identified by Phosphoproteomic and Bioinformatic Analyses. Mol Cell Proteomics. 2023;22(11):100649.
51 Intracellular zinc stores protect the intestinal epithelium from Ochratoxin A toxicity. Toxicol In Vitro. 2009 Dec;23(8):1516-21.
52 Ozone exposure and blood transcriptome: A randomized, controlled, crossover trial among healthy adults. Environ Int. 2022;163:107242.
53 Synthesis and anticancer properties of water-soluble zinc ionophores. Cancer Res. 2008 Jul 1;68(13):5318-25.
54 Proteomic analysis of human iPSC-derived sympathetic neurons identifies proteostasis collapse as a molecular signature following subtoxic rotenone exposure. Toxicology. 2025;510:154015.
55 High-throughput, quantitative assessment of the effects of low-dose silica nanoparticles on lung cells: grasping complex toxicity with a great depth of field. BMC Genomics. 2015;16(1):315.
56 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
57 Expression of ZnT and ZIP zinc transporters in the human RPE and their regulation by neurotrophic factors. Invest Ophthalmol Vis Sci. 2008;49(3):1221-31.

If you find any error in data or bug in web service, please kindly report it to Dr. Li and Dr. Fu.