Detail Information of Exogenous Modulation

General Information of Drug Transporter (DT)
DT ID	DTD0263 Transporter Info
Gene Name	SLC2A5
Transporter Name	Glucose transporter type 5, small intestine
Gene ID	6518
UniProt ID	P22732

Exogenous factors (drugs, dietary constituents, etc.) Modulation of This DT (EGM)
Chemical Compound
DT Modulation1	Colforsin promotes the reaction Fructose results in increased expression of SLC2A5 mRNA			[15]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Fructose promotes the reaction PAIP2 protein binds to SLC2A5 3' UTR			[15]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Fructose results in increased abundance of Cyclic AMP which results in increased stability of SLC2A5 mRNA			[15]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	SLC2A5 protein results in increased transport of Fructose			[32]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Colforsin promotes the reaction Glucose results in increased expression of SLC2A5 mRNA			[15]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Glucose promotes the reaction PAIP2 protein binds to SLC2A5 3' UTR			[15]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	SLC2A5 protein results in increased transport of Glucose			[33]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Fructose results in increased abundance of Cyclic AMP which results in increased stability of SLC2A5 mRNA			[15]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Colforsin promotes the reaction Fructose results in increased expression of SLC2A5 mRNA			[15]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Colforsin promotes the reaction Glucose results in increased expression of SLC2A5 mRNA			[15]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Benzo(a)pyrene affects the methylation of SLC2A5 3' UTR			[28]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Benzo(a)pyrene affects the methylation of SLC2A5 5' UTR			[28]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Benzo(a)pyrene affects the methylation of SLC2A5 promoter			[28]
Regulation Mechanism				Transcription Factor Info
1-Methyl-3-isobutylxanthine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A results in increased expression of SLC2A5 mRNA			[25]
Regulation Mechanism				Transcription Factor Info
Amphotericin B	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Amphotericin B analog results in decreased expression of SLC2A5 mRNA			[26]
Regulation Mechanism				Transcription Factor Info
arsenic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	sodium arsenate results in increased abundance of arsenic acid which results in decreased expression of SLC2A5 mRNA			[27]
Regulation Mechanism				Transcription Factor Info
beta-Naphthoflavone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	beta-Naphthoflavone results in decreased expression of SLC2A5 mRNA			[23]
Regulation Mechanism				Transcription Factor Info
bisphenol A	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	bisphenol A affects the methylation of SLC2A5 gene			[29]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	bisphenol A co-treated with Fulvestrant results in increased methylation of SLC2A5 gene			[29]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	bisphenol A results in increased expression of SLC2A5 protein			[24]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A results in increased expression of SLC2A5 mRNA			[25]
Regulation Mechanism				Transcription Factor Info
bisphenol F	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	bisphenol F results in increased expression of SLC2A5 protein			[24]
Regulation Mechanism				Transcription Factor Info
bisphenol S	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	bisphenol S results in decreased expression of SLC2A5 mRNA			[30]
Regulation Mechanism				Transcription Factor Info
Bucladesine	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Bucladesine results in increased expression of and results in increased stability of SLC2A5 mRNA			[15]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction Bucladesine results in increased expression of and results in increased stability of SLC2A5 mRNA			[15]
Regulation Mechanism				Transcription Factor Info
Dactinomycin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Dactinomycin co-treated with nutlin 3 results in increased expression of SLC2A5 mRNA			[31]
Regulation Mechanism				Transcription Factor Info
Dexamethasone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A results in increased expression of SLC2A5 mRNA			[25]
Regulation Mechanism				Transcription Factor Info
Fulvestrant	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	bisphenol A co-treated with Fulvestrant results in increased methylation of SLC2A5 gene			[29]
Regulation Mechanism				Transcription Factor Info
hydroquinone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	hydroquinone results in decreased expression of SLC2A5 mRNA			[10]
Regulation Mechanism				Transcription Factor Info
Indomethacin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A results in increased expression of SLC2A5 mRNA			[25]
Regulation Mechanism				Transcription Factor Info
Levonorgestrel	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	testosterone undecanoate co-treated with Levonorgestrel results in increased expression of SLC2A5 mRNA			[34]
Regulation Mechanism				Transcription Factor Info
monomethylarsonic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	monomethylarsonic acid results in decreased expression of SLC2A5 mRNA			[27]
Regulation Mechanism				Transcription Factor Info
monomethylarsonous acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	monomethylarsonous acid results in decreased expression of SLC2A5 mRNA			[27]
Regulation Mechanism				Transcription Factor Info
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction Bucladesine results in increased expression of and results in increased stability of SLC2A5 mRNA			[15]
Regulation Mechanism				Transcription Factor Info
nutlin 3	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Dactinomycin co-treated with nutlin 3 results in increased expression of SLC2A5 mRNA			[31]
Regulation Mechanism				Transcription Factor Info
Okadaic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Okadaic Acid results in decreased expression of SLC2A5 mRNA			[37]
Regulation Mechanism				Transcription Factor Info
Palmitic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Palmitic Acid results in decreased expression of SLC2A5 mRNA			[38]
Regulation Mechanism				Transcription Factor Info
Silicon Dioxide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Silicon Dioxide analog results in increased expression of SLC2A5 mRNA			[39]
Regulation Mechanism				Transcription Factor Info
sodium arsenate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	sodium arsenate results in increased abundance of arsenic acid which results in decreased expression of SLC2A5 mRNA			[27]
Regulation Mechanism				Transcription Factor Info
sulforaphane	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	sulforaphane results in decreased expression of SLC2A5 mRNA			[22]
Regulation Mechanism				Transcription Factor Info
tamibarotene	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	tamibarotene results in increased expression of SLC2A5 mRNA			[2]
Regulation Mechanism				Transcription Factor Info
testosterone undecanoate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	testosterone undecanoate co-treated with Levonorgestrel results in increased expression of SLC2A5 mRNA			[34]
Regulation Mechanism				Transcription Factor Info
trichostatin A	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	trichostatin A inhibits the reaction Nickel affects the expression of SLC2A5 mRNA			[35]
Regulation Mechanism				Transcription Factor Info
triphenyl phosphate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	triphenyl phosphate affects the expression of SLC2A5 mRNA			[40]
Regulation Mechanism				Transcription Factor Info
tris(2-butoxyethyl) phosphate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	tris(2-butoxyethyl) phosphate affects the expression of SLC2A5 mRNA			[41]
Regulation Mechanism				Transcription Factor Info
Valproic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Valproic Acid results in increased methylation of SLC2A5 gene			[42]
Regulation Mechanism				Transcription Factor Info
Dietary Constituent
Iron	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Iron deficiency results in decreased expression of SLC2A5 mRNA			[17]
Regulation Mechanism				Transcription Factor Info
Approved Drug
Mirtazapine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Mirtazapine increases the expression of SLC2A5			[3]
Calcitriol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Calcitriol inhibits the expression of SLC2A5			[4]
Methamphetamine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Methamphetamine increases the expression of SLC2A5			[5]
Arsenic Trioxide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Arsenic Trioxide increases the expression of SLC2A5			[6]
Cisplatin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cisplatin increases the expression of SLC2A5			[8]
Pioglitazone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Pioglitazone inhibits the expression of SLC2A5			[9]
Hydroquinone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Hydroquinone inhibits the expression of SLC2A5			[10]
Tretinoin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tretinoin increases the expression of SLC2A5			[11]
Drug Marketed but not Approved by US FDA
Demecolcine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Demecolcine increases the expression of SLC2A5			[7]
Drug in Phase 2/3 Trial
AM-80	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	AM-80 increases the expression of SLC2A5			[2]
Drug in Phase 3 Trial
Sulforafan	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sulforafan inhibits the expression of SLC2A5			[22]
Drug in Phase 2 Trial
Colforsin	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Colforsin increases the expression of SLC2A5			[15]
Bisphenol A	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Bisphenol A increases the expression of SLC2A5			[24]
Drug in Phase 1 Trial
Cyclic AMP	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cyclic AMP affects the expression of SLC2A5			[14]
Drug in Preclinical Test
(+)-JQ1	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	(+)-JQ1 inhibits the expression of SLC2A5			[20]
Investigative Drug
N-[4-(methylsulfonyl)-2-nitrophenyl]-1,3-benzodioxol-5-amine (MSNBA)	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	N-[4-(methylsulfonyl)-2-nitrophenyl]-1,3-benzodioxol-5-amine (MSNBA) inhibits the transportation of Fructose by SLC2A5 (Ki = 3.2 microM)			[1]
Affected Drug/Substrate	Fructose	Modulation Type	Inhibition
Cell System	Human breast adenocarcinoma cell line (MCF-7)-GLUT5
Glucose	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Glucose increases the expression of SLC2A5			[13]
Regulation Mechanism	via enhancement of Protein c-Fos (FOS)			Transcription Factor Info
Cell System	Mouse microglia cells (SIM-A9)
Beta-naphthoflavone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Beta-naphthoflavone inhibits the expression of SLC2A5			[23]
Natural Product
Fructose	5 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Fructose increases the expression of SLC2A5			[12]
Regulation Mechanism	via enhancement of Oxysterols receptor LXR-alpha (NR1H3)			Transcription Factor Info
Cell System	C57BL/6J mice
Environmental toxicant
Zinc	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Zinc increases the expression of SLC2A5			[19]
Bisphenol F	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Bisphenol F increases the expression of SLC2A5			[24]
Mycotoxins
Aflatoxin B1	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Aflatoxin B1 increases the expression of SLC2A5			[18]
Acute Toxic Substance
Formaldehyde	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Formaldehyde inhibits the expression of SLC2A5			[21]
Carcinogen
Benzo(a)pyrene	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Benzo(a)pyrene inhibits the expression of SLC2A5			[16]
Ethyl Methanesulfonate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ethyl Methanesulfonate increases the expression of SLC2A5			[7]
DT Modulation1	Formaldehyde results in increased expression of SLC2A5 mRNA			[7]
Regulation Mechanism				Transcription Factor Info
Arsenic	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLC2A5 protein results in increased transport of Arsenic			[6]
Regulation Mechanism				Transcription Factor Info
Nickel	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Nickel affects the expression of SLC2A5 mRNA			[35]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Nickel results in increased expression of SLC2A5 mRNA			[36]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	trichostatin A inhibits the reaction Nickel affects the expression of SLC2A5 mRNA			[35]
Regulation Mechanism				Transcription Factor Info
Health and Environmental Toxicant
Nano-sized iron particle	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Nano-sized iron particle inhibits the expression of SLC2A5			[17]

References
1	Discovery of a specific inhibitor of human GLUT5 by virtual screening and in vitro transport evaluation. Sci Rep. 2016 Apr 14;6:24240.
2	Differential modulation of PI3-kinase/Akt pathway during all-trans retinoic acid- and Am80-induced HL-60 cell differentiation revealed by DNA microarray analysis. Biochem Pharmacol. 2004 Dec 1;68(11):2177-86.
3	Effects of different antipsychotics and the antidepressant mirtazapine on glucose transporter mRNA levels in human blood cells. J Psychiatr Res. 2006 Jun;40(4):374-9.
4	Large-scale in silico and microarray-based identification of direct 1,25-dihydroxyvitamin D3 target genes. Mol Endocrinol. 2005 Nov;19(11):2685-95.
5	Microglial and astrocytic changes in the striatum of methamphetamine abusers. Leg Med (Tokyo). 2010 Mar;12(2):57-62.
6	In vitro study of transporters involved in intestinal absorption of inorganic arsenic. Chem Res Toxicol. 2012 Feb 20;25(2):446-53.
7	Characterization of formaldehyde's genotoxic mode of action by gene expression analysis in TK6 cells. Arch Toxicol. 2013 Nov;87(11):1999-2012.
8	Low Doses of Cisplatin Induce Gene Alterations, Cell Cycle Arrest, and Apoptosis in Human Promyelocytic Leukemia Cells. Biomark Insights. 2016 Aug 24;11:113-21.
9	Peroxisome proliferator activated receptor gamma (PPAR-Gamma) ligand pioglitazone regulated gene networks in term human primary trophoblast cells. Reprod Toxicol. 2018 Oct;81:99-107.
10	Keratinocyte-derived IL-36 Gamma plays a role in hydroquinone-induced chemical leukoderma through inhibition of melanogenesis in human epidermal melanocytes. Arch Toxicol. 2019 Aug;93(8):2307-2320.
11	Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423.
12	Identification of the fructose transporter GLUT5 (SLC2A5) as a novel target of nuclear receptor LXR. Sci Rep. 2019 Jun 26;9(1):9299.
13	Regulation of the Fructose Transporter Gene Slc2a5 Expression by Glucose in Cultured Microglial Cells. Int J Mol Sci. 2021 Nov 23;22(23):12668.
14	Sugar-dependent expression of the fructose transporter GLUT5 in Caco-2 cells. Biochem J. 1995 Dec 15;312 ( Pt 3)(Pt 3):757-62.
15	Fructose modulates GLUT5 mRNA stability in differentiated Caco-2 cells: role of cAMP-signalling pathway and PABP (polyadenylated-binding protein)-interacting protein (Paip) 2. Biochem J. 2003 Oct 1;375(Pt 1):167-74.
16	Transcriptional signature of human macrophages exposed to the environmental contaminant benzo(a)pyrene. Toxicol Sci. 2010 Apr;114(2):247-59.
17	Targeting iron homeostasis induces cellular differentiation and synergizes with differentiating agents in acute myeloid leukemia. J Exp Med. 2010 Apr 12;207(4):731-50.
18	Aflatoxins upregulate CYP3A4 mRNA expression in a process that involves the PXR transcription factor. Toxicol Lett. 2011 Aug 28;205(2):146-53.
19	Genomic analysis, cytokine expression, and microRNA profiling reveal biomarkers of human dietary zinc depletion and homeostasis. Proc Natl Acad Sci U S A. 2011 Dec 27;108(52):20970-5.
20	Highly active combination of BRD4 antagonist and histone deacetylase inhibitor against human acute myelogenous leukemia cells. Mol Cancer Ther. 2014 May;13(5):1142-54.
21	Cystathionine metabolic enzymes play a role in the inflammation resolution of human keratinocytes in response to sub-cytotoxic formaldehyde exposure. Toxicol Appl Pharmacol. 2016 Nov 1;310:185-194.
22	Transcriptome and DNA methylation changes modulated by sulforaphane induce cell cycle arrest, apoptosis, DNA damage, and suppression of proliferation in human liver cancer cells. Food Chem Toxicol. 2020 Feb;136:111047.
23	Aryl hydrocarbon receptor (AhR) agonist beta-naphthoflavone regulated gene networks in human primary trophoblasts. Reprod Toxicol. 2020 Sep;96:370-379.
24	Alternatives for the worse: Molecular insights into adverse effects of bisphenol a and substitutes during human adipocyte differentiation. Environ Int. 2021 Nov;156:106730.
25	Low-dose exposure to bisphenols A, F and S of human primary adipocyte impacts coding and non-coding RNA profiles. PLoS One. 2017;12(6):e0179583.
26	Differential expression of microRNAs and their predicted targets in renal cells exposed to amphotericin B and its complex with copper (II) ions. Toxicol Mech Methods. 2017;27(7):537-543.
27	Characterizing the toxicological responses to inorganic arsenicals and their metabolites in immortalized human bladder epithelial cells. Arch Toxicol. 2024;98(7):2065-2084.
28	Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017;8(1):1369-1391.
29	DNA methylome-wide alterations associated with estrogen receptor-dependent effects of bisphenols in breast cancer. Clin Epigenetics. 2019;11(1):138.
30	Bisphenol A and Bisphenol S Induce Distinct Transcriptional Profiles in Differentiating Human Primary Preadipocytes. PLoS One. 2016 Sep 29;11(9):e0163318.
31	Transcriptomic and proteomic study of cancer cell lines exposed to actinomycin D and nutlin-3a reveals numerous, novel candidates for p53-regulated genes. Chem Biol Interact. 2024;392:110946.
32	Fructose transporter in human spermatozoa and small intestine is GLUT5. J Biol Chem. 1992;267(21):14523-6.
33	A highly conserved hydrophobic motif in the exofacial vestibule of fructose transporting SLC2A proteins acts as a critical determinant of their substrate selectivity. Mol Membr Biol. 2007;24(5-6):455-63.
34	Levonorgestrel enhances spermatogenesis suppression by testosterone with greater alteration in testicular gene expression in men. Biol Reprod. 2009 Mar;80(3):484-92.
35	Inhibition and reversal of nickel-induced transformation by the histone deacetylase inhibitor trichostatin A. Toxicol Appl Pharmacol. 2003;192(3):201-11.
36	Patients with atopic dermatitis have attenuated and distinct contact hypersensitivity responses to common allergens in skin. J Allergy Clin Immunol. 2015;135(3):712-20.
37	A multi-omics approach to elucidate okadaic acid-induced changes in human HepaRG hepatocarcinoma cells. Arch Toxicol. 2024;98(9):2919-2935.
38	Palmitic Acid Induced a Dedifferentiation Profile at the Transcriptome Level: A Collagen Synthesis but no Triglyceride Accumulation in Hepatocyte-Like Cells Derived From Human-Induced Pluripotent Stem Cells Cultivated Inside Organ on a Chip. J Appl Toxicol. 2025;45(3):460-471.
39	Transcriptional responses of human aortic endothelial cells to nanoconstructs used in biomedical applications. Mol Pharm. 2013;10(8):3242-52.
40	Association between Organophosphate Ester Exposure and Insulin Resistance with Glycometabolic Disorders among Older Chinese Adults 60-69 Years of Age: Evidence from the China BAPE Study. Environ Health Perspect. 2023;131(4):47009.
41	Toxicogenomics of the flame retardant tris (2-butoxyethyl) phosphate in HepG2 cells using RNA-seq. Toxicol In Vitro. 2018;46:178-188.
42	Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.

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Detail Information of Exogenous Modulation

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