Detail Information of Exogenous Modulation
General Information of Drug Transporter (DT) | |||||
---|---|---|---|---|---|
DT ID | DTD0258 Transporter Info | ||||
Gene Name | SLC2A3 | ||||
Transporter Name | Glucose transporter type 3, brain | ||||
Gene ID | |||||
UniProt ID | |||||
Exogenous factors (drugs, dietary constituents, etc.) Modulation of This DT (EGM) | |||||
---|---|---|---|---|---|
Mycotoxins |
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Aflatoxin B1 |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Aflatoxin B1 results in decreased methylation of SLC2A3 3' UTR | [65] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
Aflatoxin B1 results in decreased methylation of SLC2A3 intron | [65] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Biotoxin |
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yessotoxin |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
yessotoxin analog results in increased expression of SLC2A3 mRNA | [54] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Approved Drug |
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Bevacizumab |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Bevacizumab induces the transportation of Glucose by SLC2A3 | [1] | |||
Affected Drug/Substrate |
Glucose | Modulation Type | Inducer | ||
Oxaliplatin |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Oxaliplatin inhibits the expression of SLC2A3 | [2] | |||
Regulation Mechanism |
via the inhibition of Transcriptional repressor protein YY1 (YY1) | Transcription Factor Info | |||
Cell System |
Human colon carcinoma isolates | ||||
Raloxifene Hydrochloride |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Raloxifene Hydrochloride affects the expression of SLC2A3 | [3] | |||
Chlorpromazine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Chlorpromazine inhibits the expression of SLC2A3 | [4] | |||
Clozapine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Clozapine inhibits the expression of SLC2A3 | [4] | |||
Flecainide |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Flecainide inhibits the expression of SLC2A3 | [4] | |||
Pentamidine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Pentamidine inhibits the expression of SLC2A3 | [4] | |||
Sotalol |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Sotalol increases the expression of SLC2A3 | [4] | |||
Thioridazine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Thioridazine inhibits the expression of SLC2A3 | [4] | |||
Vandetanib |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Vandetanib increases the expression of SLC2A3 | [5] | |||
Tretinoin |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Tretinoin inhibits the expression of SLC2A3 | [6] | |||
Gemcitabine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Gemcitabine increases the expression of SLC2A3 | [7] | |||
Acetaminophen |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Acetaminophen inhibits the expression of SLC2A3 | [8] | |||
DT Modulation2 |
Acetaminophen results in increased expression of SLC2A3 mRNA | [63] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Citalopram |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Citalopram inhibits the expression of SLC2A3 | [9] | |||
Doxepin |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Doxepin inhibits the expression of SLC2A3 | [9] | |||
Bortezomib |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Bortezomib increases the expression of SLC2A3 | [10] | |||
Calcitriol |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Calcitriol increases the expression of SLC2A3 | [11] | |||
Testosterone |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Testosterone increases the expression of SLC2A3 | [11] | |||
Ampicillin |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Ampicillin increases the expression of SLC2A3 | [12] | |||
Niclosamide |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Niclosamide inhibits the expression of SLC2A3 | [13] | |||
Zidovudine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Zidovudine inhibits the expression of SLC2A3 | [15] | |||
Methotrexate |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Methotrexate inhibits the expression of SLC2A3 | [16] | |||
Caffeine |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Caffeine increases the expression of SLC2A3 | [17] | |||
Carbamazepine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Carbamazepine affects the expression of SLC2A3 | [18] | |||
Panobinostat |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Panobinostat increases the expression of SLC2A3 | [19] | |||
Vorinostat |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Vorinostat increases the expression of SLC2A3 | [19] | |||
Cisplatin |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Cisplatin increases the expression of SLC2A3 | [20] | |||
Urethane |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Urethane inhibits the expression of SLC2A3 | [21] | |||
Doxorubicin |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Doxorubicin inhibits the expression of SLC2A3 | [22] | |||
Avobenzone |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Avobenzone increases the expression of SLC2A3 | [23] | |||
Cannabidiol |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Cannabidiol increases the expression of SLC2A3 | [24] | |||
Sunitinib |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Sunitinib increases the expression of SLC2A3 | [25] | |||
Clomipramine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Clomipramine inhibits the expression of SLC2A3 | [8] | |||
Amitriptyline |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Amitriptyline inhibits the expression of SLC2A3 | [9] | |||
Fluoxetine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Fluoxetine inhibits the expression of SLC2A3 | [9] | |||
Imipramine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Imipramine inhibits the expression of SLC2A3 | [9] | |||
Ketoconazole |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Ketoconazole inhibits the expression of SLC2A3 | [9] | |||
Loratadine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Loratadine inhibits the expression of SLC2A3 | [9] | |||
Quinidine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Quinidine inhibits the expression of SLC2A3 | [9] | |||
Sertraline |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Sertraline inhibits the expression of SLC2A3 | [9] | |||
Tamoxifen |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Tamoxifen inhibits the expression of SLC2A3 | [9] | |||
Amiodarone |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Amiodarone inhibits the expression of SLC2A3 | [27] | |||
Cyclosporine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Cyclosporine inhibits the expression of SLC2A3 | [28] | |||
Arsenic Trioxide |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Arsenic Trioxide increases the expression of SLC2A3 | [29] | |||
Valproic Acid |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Valproic Acid increases the expression of SLC2A3 | [30] | |||
Estradiol |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Estradiol increases the expression of SLC2A3 | [31] | |||
Regulation Mechanism |
via enhancement of Cyclic AMP-responsive element-binding protein 1 (CREB1) | Transcription Factor Info | |||
Affected Drug/Substrate |
Glucose | Modulation Type | Inducer | ||
Cell System |
Human neuroblastoma cells (SH-SY5Y) | ||||
Drug Marketed but not Approved by US FDA |
|||||
Demecolcine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Demecolcine increases the expression of SLC2A3 | [14] | |||
Rotenone |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Rotenone inhibits the expression of SLC2A3 | [26] | |||
Drug in Phase 3 Trial |
|||||
torcetrapib |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
torcetrapib increases the expression of SLC2A3 | [41] | |||
Sulforafan |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Sulforafan increases the expression of SLC2A3 | [47] | |||
Triclosan |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Triclosan inhibits the expression of SLC2A3 | [53] | |||
Epigallocatechin gallate |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Epigallocatechin gallate increases the expression of SLC2A3 | [58] | |||
Drug in Phase 2 Trial |
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MS-275 |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
MS-275 increases the expression of SLC2A3 | [19] | |||
Bisphenol A |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Bisphenol A affects the expression of SLC2A3 | [56] | |||
Drug in Phase 1 Trial |
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Chlorcyclizine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Chlorcyclizine inhibits the expression of SLC2A3 | [4] | |||
WSM-3978G |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
WSM-3978G inhibits the expression of SLC2A3 | [4] | |||
Dinitrochlorobenzene |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Dinitrochlorobenzene inhibits the expression of SLC2A3 | [35] | |||
Quercetin |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Quercetin inhibits the expression of SLC2A3 | [12] | |||
Dihydrotestosterone |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Dihydrotestosterone increases the expression of SLC2A3 | [51] | |||
Sodium arsenite |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Sodium arsenite inhibits the expression of SLC2A3 | [60] | |||
Trichostatin A |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Trichostatin A increases the expression of SLC2A3 | [19] | |||
Drug in Preclinical Test |
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(+)-JQ1 |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
(+)-JQ1 inhibits the expression of SLC2A3 | [40] | |||
Investigative Drug |
|||||
Tributyltin |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Tributyltin inhibits the expression of SLC2A3 | [35] | |||
Archazolid B |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Archazolid B increases the expression of SLC2A3 | [43] | |||
SB-431542 |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
SB-431542 increases the expression of SLC2A3 | [44] | |||
Phenylmercuric Acetate |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Phenylmercuric Acetate increases the expression of SLC2A3 | [19] | |||
PP242 |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
PP242 inhibits the expression of SLC2A3 | [54] | |||
Milchsaure |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Milchsaure affects the expression of SLC2A3 | [55] | |||
Patented Pharmaceutical Agent |
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Eugenol |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Eugenol increases the expression of SLC2A3 | [34] | |||
K-7174 |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
K-7174 inhibits the expression of SLC2A3 | [42] | |||
GSK-J4 |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
GSK-J4 increases the expression of SLC2A3 | [50] | |||
Natural Product |
|||||
DT Modulation1 |
Caffeine affects the phosphorylation of SLC2A3 protein | [82] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Particulate Matter |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Particulate Matter increases the expression of SLC2A3 | [38] | |||
Tobacco Smoke Pollution |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Tobacco Smoke Pollution inhibits the expression of SLC2A3 | [59] | |||
Environmental toxicant |
|||||
Resorcinol |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Resorcinol increases the expression of SLC2A3 | [39] | |||
Polychlorinated dibenzodioxin |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Polychlorinated dibenzodioxin inhibits the expression of SLC2A3 | [12] | |||
Lead |
4 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
lead acetate results in increased abundance of Lead which results in decreased expression of SLC2A3 mRNA | [93] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
lead acetate results in increased abundance of Lead which results in decreased expression of SLC2A3 protein | [93] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation3 |
PPIF protein affects the reaction lead acetate results in increased abundance of Lead which results in decreased expression of SLC2A3 mRNA | [93] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation4 |
PPIF protein affects the reaction lead acetate results in increased abundance of Lead which results in decreased expression of SLC2A3 protein | [93] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Acute Toxic Substance |
|||||
trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride inhibits the expression of SLC2A3 | [4] | |||
Uranium |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Uranium affects the expression of SLC2A3 | [32] | |||
Nickel chloride |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Nickel chloride increases the expression of SLC2A3 | [33] | |||
Cadmium |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Cadmium inhibits the expression of SLC2A3 | [36] | |||
Thimerosal |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Thimerosal inhibits the expression of SLC2A3 | [48] | |||
Formaldehyde |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Formaldehyde increases the expression of SLC2A3 | [49] | |||
Carcinogen |
|||||
Benzo(a)pyrene |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Benzo(a)pyrene inhibits the expression of SLC2A3 | [61] | |||
Arsenic |
3 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
sodium arsenate results in increased abundance of Arsenic which results in increased expression of SLC2A3 mRNA | [71] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
sodium arsenite results in increased abundance of Arsenic co-treated with manganese chloride results in increased abundance of Manganese results in increased expression of SLC2A3 mRNA | [72] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation3 |
sodium arsenite results in increased abundance of Arsenic which results in increased expression of SLC2A3 mRNA | [72] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Nickel |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Nickel results in increased expression of SLC2A3 mRNA | [96] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Health and Environmental Toxicant |
|||||
Butyraldehyde |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Butyraldehyde inhibits the expression of SLC2A3 | [45] | |||
tris(1,3-dichloro-2-propyl)phosphate |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
tris(1,3-dichloro-2-propyl)phosphate inhibits the expression of SLC2A3 | [46] | |||
Diethylhexyl Phthalate |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Diethylhexyl Phthalate increases the expression of SLC2A3 | [57] | |||
Nanoparticle |
|||||
Silver nanoparticle |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Silver nanoparticle increases the expression of SLC2A3 | [52] | |||
Chemical Compound |
|||||
DT Modulation1 |
Flecainide results in increased expression of SLC2A3 mRNA | [8] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Tretinoin results in increased expression of SLC2A3 mRNA | [114] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Testosterone co-treated with Calcitriol results in increased expression of SLC2A3 mRNA | [11] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Testosterone co-treated with Calcitriol results in increased expression of SLC2A3 mRNA | [11] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Niclosamide results in increased expression of SLC2A3 mRNA | [98] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC2A3 mRNA | [48] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
NOG protein co-treated with Vorinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC2A3 mRNA | [48] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Rotenone results in increased expression of SLC2A3 protein | [109] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Tamoxifen affects the expression of SLC2A3 mRNA | [3] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC2A3 mRNA | [48] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Estradiol co-treated with TGFB1 protein results in decreased expression of SLC2A3 mRNA | [90] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Dinitrochlorobenzene results in increased expression of SLC2A3 mRNA | [34] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Dinitrofluorobenzene |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Dinitrofluorobenzene increases the expression of SLC2A3 | [37] | |||
Pentanal |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Pentanal inhibits the expression of SLC2A3 | [45] | |||
DT Modulation1 |
NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC2A3 mRNA | [48] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Benzo(a)pyrene affects the methylation of SLC2A3 intron | [65] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide |
10 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC2A3 protein | [44] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC2A3 mRNA | [48] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation3 |
NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC2A3 mRNA | [48] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation4 |
NOG protein co-treated with methylmercuric chloride co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC2A3 mRNA | [48] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation5 |
NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC2A3 mRNA | [48] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation6 |
NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC2A3 mRNA | [48] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation7 |
NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC2A3 mRNA | [48] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation8 |
NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC2A3 mRNA | [48] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation9 |
NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC2A3 mRNA | [48] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation10 |
NOG protein co-treated with Vorinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC2A3 mRNA | [48] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
4-phenylenediamine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
4-phenylenediamine results in increased expression of SLC2A3 mRNA | [35] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
abrine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
abrine results in decreased expression of SLC2A3 mRNA | [62] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Acetylcysteine |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Acetylcysteine inhibits the reaction epigallocatechin gallate results in increased expression of SLC2A3 mRNA | [58] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
Acetylcysteine inhibits the reaction epigallocatechin gallate results in increased expression of SLC2A3 protein | [58] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Acetylglucosamine |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Acetylglucosamine results in decreased expression of SLC2A3 mRNA | [64] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
Acetylglucosamine results in increased expression of SLC2A3 mRNA | [64] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Aldehydes |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Aldehydes results in decreased expression of SLC2A3 mRNA | [66] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
amyloid beta-protein (1-40) |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
amyloid beta-protein (1-40) results in decreased expression of SLC2A3 protein | [67] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Antimony Potassium Tartrate |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Antimony Potassium Tartrate results in increased abundance of antimonite which results in increased expression of SLC2A3 mRNA | [68] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Apigenin |
3 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Apigenin co-treated with Oxygen deficiency results in decreased expression of SLC2A3 mRNA | [69] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
Apigenin results in decreased expression of SLC2A3 mRNA | [70] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation3 |
Apigenin results in decreased expression of SLC2A3 protein | [70] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
archazolid B |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
archazolid B results in increased expression of SLC2A3 mRNA | [43] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Asbestos, Crocidolite |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Asbestos, Crocidolite results in increased expression of SLC2A3 mRNA | [73] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Asbestos, Serpentine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Asbestos, Serpentine results in increased expression of SLC2A3 mRNA | [74] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
avobenzone |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
avobenzone results in increased expression of SLC2A3 mRNA | [23] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
benzo(e)pyrene |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
benzo(e)pyrene results in increased methylation of SLC2A3 intron | [65] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
beta-lapachone |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
beta-lapachone results in increased expression of SLC2A3 mRNA | [75] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
bisphenol A |
3 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
bisphenol A affects the expression of SLC2A3 mRNA | [56] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
bisphenol A results in decreased methylation of SLC2A3 gene | [76] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation3 |
bisphenol A results in increased expression of SLC2A3 mRNA | [77] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
bruceine D |
3 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
bruceine D affects the reaction Oxygen deficiency affects the expression of SLC2A3 protein | [78] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
bruceine D results in decreased expression of SLC2A3 protein | [78] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation3 |
CTNNBIP1 protein affects the reaction bruceine D affects the reaction Oxygen deficiency affects the expression of SLC2A3 protein | [78] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
butyraldehyde |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
butyraldehyde results in decreased expression of SLC2A3 mRNA | [45] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Cadmium Chloride |
3 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Cadmium Chloride results in decreased expression of SLC2A3 mRNA | [79] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
Cadmium Chloride results in increased expression of SLC2A3 mRNA | [80] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation3 |
sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate results in decreased expression of SLC2A3 mRNA | [81] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
chlorcyclizine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
chlorcyclizine results in decreased expression of SLC2A3 mRNA | [4] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
chromic oxide |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate results in decreased expression of SLC2A3 mRNA | [81] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
chromous chloride |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate results in decreased expression of SLC2A3 mRNA | [81] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
cobaltous chloride |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
cobaltous chloride results in increased expression of SLC2A3 mRNA | [83] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Copper |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Organoselenium Compounds binds to Copper which results in increased expression of SLC2A3 mRNA | [84] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Cytochalasin B |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Cytochalasin B inhibits the reaction SLC2A3 protein results in increased transport of Deoxyglucose | [85] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Dehydroascorbic Acid |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
SLC2A3 protein affects the transport of Dehydroascorbic Acid | [86] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Deoxyglucose |
5 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Cytochalasin B inhibits the reaction SLC2A3 protein results in increased transport of Deoxyglucose | [85] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
Galactose inhibits the reaction SLC2A3 protein results in increased transport of Deoxyglucose | [85] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation3 |
Glucose inhibits the reaction SLC2A3 protein results in increased transport of Deoxyglucose | [85] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation4 |
Maltose inhibits the reaction SLC2A3 protein results in increased transport of Deoxyglucose | [85] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation5 |
SLC2A3 protein results in increased transport of Deoxyglucose | [85] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
diallyl trisulfide |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
diallyl trisulfide results in increased expression of SLC2A3 mRNA | [87] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
di-n-butylphosphoric acid |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
di-n-butylphosphoric acid affects the expression of SLC2A3 mRNA | [88] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
dorsomorphin |
9 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC2A3 mRNA | [48] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC2A3 mRNA | [48] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation3 |
NOG protein co-treated with methylmercuric chloride co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC2A3 mRNA | [48] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation4 |
NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC2A3 mRNA | [48] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation5 |
NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC2A3 mRNA | [48] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation6 |
NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC2A3 mRNA | [48] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation7 |
NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC2A3 mRNA | [48] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation8 |
NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC2A3 mRNA | [48] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation9 |
NOG protein co-treated with Vorinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC2A3 mRNA | [48] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
entinostat |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
entinostat results in increased expression of SLC2A3 mRNA | [19] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC2A3 mRNA | [48] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
epigallocatechin gallate |
5 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Acetylcysteine inhibits the reaction epigallocatechin gallate results in increased expression of SLC2A3 mRNA | [58] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
Acetylcysteine inhibits the reaction epigallocatechin gallate results in increased expression of SLC2A3 protein | [58] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation3 |
epigallocatechin gallate results in increased expression of SLC2A3 mRNA | [58] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation4 |
epigallocatechin gallate results in increased expression of SLC2A3 protein | [58] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation5 |
potassium chromate(VI) co-treated with epigallocatechin gallate results in increased expression of SLC2A3 mRNA | [89] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
fisetin |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
fisetin co-treated with Oxygen deficiency results in decreased expression of SLC2A3 mRNA | [69] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Fluorouracil |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
SLC2A3 protein affects the susceptibility to Fluorouracil | [91] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Galactose |
4 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Galactose inhibits the reaction SLC2A3 protein results in increased transport of Deoxyglucose | [85] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
Glucose inhibits the reaction SLC2A3 protein results in increased transport of Galactose | [85] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation3 |
Maltose inhibits the reaction SLC2A3 protein results in increased transport of Galactose | [85] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation4 |
SLC2A3 protein results in increased transport of Galactose | [85] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Glucose |
4 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Glucose inhibits the reaction SLC2A3 protein results in increased transport of Deoxyglucose | [85] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
Glucose inhibits the reaction SLC2A3 protein results in increased transport of Galactose | [85] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation3 |
INS protein co-treated with Glucose results in decreased expression of SLC2A3 protein | [92] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation4 |
Kynurenic Acid inhibits the reaction INS protein co-treated with Glucose results in decreased expression of SLC2A3 protein | [92] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
K 7174 |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
K 7174 results in decreased expression of SLC2A3 mRNA | [42] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Kynurenic Acid |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Kynurenic Acid inhibits the reaction INS protein co-treated with Glucose results in decreased expression of SLC2A3 protein | [92] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Lactic Acid |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Lactic Acid affects the expression of SLC2A3 mRNA | [55] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
lead acetate |
5 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
lead acetate results in increased abundance of Lead which results in decreased expression of SLC2A3 mRNA | [93] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
lead acetate results in increased abundance of Lead which results in decreased expression of SLC2A3 protein | [93] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation3 |
PPIF protein affects the reaction lead acetate results in increased abundance of Lead which results in decreased expression of SLC2A3 mRNA | [93] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation4 |
PPIF protein affects the reaction lead acetate results in increased abundance of Lead which results in decreased expression of SLC2A3 protein | [93] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation5 |
sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate results in decreased expression of SLC2A3 mRNA | [81] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Luteolin |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Luteolin co-treated with Oxygen deficiency results in decreased expression of SLC2A3 mRNA | [69] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Maltose |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Maltose inhibits the reaction SLC2A3 protein results in increased transport of Deoxyglucose | [85] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
Maltose inhibits the reaction SLC2A3 protein results in increased transport of Galactose | [85] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Manganese |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
manganese chloride results in increased abundance of Manganese which results in increased expression of SLC2A3 mRNA | [72] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
sodium arsenite results in increased abundance of Arsenic co-treated with manganese chloride results in increased abundance of Manganese results in increased expression of SLC2A3 mRNA | [72] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
manganese chloride |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
manganese chloride results in increased abundance of Manganese which results in increased expression of SLC2A3 mRNA | [72] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
sodium arsenite results in increased abundance of Arsenic co-treated with manganese chloride results in increased abundance of Manganese results in increased expression of SLC2A3 mRNA | [72] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
mercuric bromide |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
mercuric bromide results in increased expression of SLC2A3 mRNA | [19] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC2A3 mRNA | [48] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Methapyrilene |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Methapyrilene results in increased methylation of SLC2A3 intron | [65] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
methylmercuric chloride |
3 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
methylmercuric chloride results in decreased expression of SLC2A3 mRNA | [94] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
methylmercuric chloride results in increased expression of SLC2A3 mRNA | [94] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation3 |
NOG protein co-treated with methylmercuric chloride co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC2A3 mRNA | [48] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
NCS 382 |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
NCS 382 results in decreased expression of SLC2A3 mRNA | [95] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
nickel chloride |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
nickel chloride results in increased expression of SLC2A3 mRNA | [33] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
nickel sulfate |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
nickel sulfate results in increased expression of SLC2A3 mRNA | [97] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
nimbolide |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
nimbolide results in decreased expression of SLC2A3 mRNA | [99] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
NVP-BKM120 |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
sotorasib co-treated with trametinib co-treated with NVP-BKM120 results in decreased expression of SLC2A3 mRNA | [100] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Oxazolone |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Oxazolone results in increased expression of SLC2A3 mRNA | [34] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Oxygen |
10 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Apigenin co-treated with Oxygen deficiency results in decreased expression of SLC2A3 mRNA | [69] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
bruceine D affects the reaction Oxygen deficiency affects the expression of SLC2A3 protein | [78] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation3 |
CTNNBIP1 protein affects the reaction bruceine D affects the reaction Oxygen deficiency affects the expression of SLC2A3 protein | [78] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation4 |
fisetin co-treated with Oxygen deficiency results in decreased expression of SLC2A3 mRNA | [69] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation5 |
HIF1A protein affects the reaction Oxygen deficiency results in increased expression of SLC2A3 protein | [101] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation6 |
Luteolin co-treated with Oxygen deficiency results in decreased expression of SLC2A3 mRNA | [69] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation7 |
Oxygen deficiency affects the expression of SLC2A3 protein | [78] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation8 |
Oxygen deficiency results in increased expression of SLC2A3 mRNA | [102] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation9 |
Oxygen deficiency results in increased expression of SLC2A3 protein | [101] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation10 |
ST6GAL1 protein promotes the reaction Oxygen deficiency results in increased expression of SLC2A3 mRNA | [103] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Palmitic Acid |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Palmitic Acid results in increased expression of SLC2A3 mRNA | [104] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
p-Chloromercuribenzoic Acid |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC2A3 mRNA | [48] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
p-Chloromercuribenzoic Acid results in increased expression of SLC2A3 mRNA | [19] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
PCI 5002 |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
PCI 5002 co-treated with Zinc results in increased expression of SLC2A3 mRNA | [105] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
pentanal |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
pentanal results in decreased expression of SLC2A3 mRNA | [45] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
perfluorooctanoic acid |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
perfluorooctanoic acid results in decreased expression of SLC2A3 protein | [106] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Perhexiline |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Perhexiline results in decreased expression of SLC2A3 mRNA | [4] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
Perhexiline results in increased expression of SLC2A3 mRNA | [8] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
PF-06840003 |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
PF-06840003 inhibits the reaction MAPT protein mutant form results in decreased expression of SLC2A3 mRNA | [107] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Pioglitazone |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Pioglitazone co-treated with tert-Butylhydroperoxide results in increased expression of SLC2A3 mRNA | [108] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
potassium chromate(VI) |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
potassium chromate(VI) co-treated with epigallocatechin gallate results in increased expression of SLC2A3 mRNA | [89] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
potassium chromate(VI) results in increased expression of SLC2A3 mRNA | [89] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
resorcinol |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
resorcinol results in increased expression of SLC2A3 mRNA | [39] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Rosiglitazone |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Rosiglitazone co-treated with tert-Butylhydroperoxide results in increased expression of SLC2A3 mRNA | [108] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
Rosiglitazone inhibits the reaction tert-Butylhydroperoxide results in increased expression of SLC2A3 mRNA | [108] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
S-(1,2-dichlorovinyl)cysteine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
S-(1,2-dichlorovinyl)cysteine co-treated with Lipopolysaccharides results in decreased expression of SLC2A3 mRNA | [110] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Silicon Dioxide |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Silicon Dioxide results in decreased expression of SLC2A3 mRNA | [111] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
Silicon Dioxide results in increased expression of SLC2A3 mRNA | [73] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
sodium arsenate |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
sodium arsenate results in increased abundance of Arsenic which results in increased expression of SLC2A3 mRNA | [71] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
sodium arsenite |
5 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate results in decreased expression of SLC2A3 mRNA | [81] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
sodium arsenite results in decreased expression of SLC2A3 mRNA | [81] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation3 |
sodium arsenite results in increased abundance of Arsenic co-treated with manganese chloride results in increased abundance of Manganese results in increased expression of SLC2A3 mRNA | [72] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation4 |
sodium arsenite results in increased abundance of Arsenic which results in increased expression of SLC2A3 mRNA | [72] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation5 |
sodium arsenite results in increased expression of SLC2A3 mRNA | [112] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
sotorasib |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
sotorasib co-treated with trametinib co-treated with NVP-BKM120 results in decreased expression of SLC2A3 mRNA | [100] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
sulforaphane |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
sulforaphane results in increased expression of SLC2A3 mRNA | [47] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
tert-Butylhydroperoxide |
6 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Pioglitazone co-treated with tert-Butylhydroperoxide results in increased expression of SLC2A3 mRNA | [108] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
Rosiglitazone co-treated with tert-Butylhydroperoxide results in increased expression of SLC2A3 mRNA | [108] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation3 |
Rosiglitazone inhibits the reaction tert-Butylhydroperoxide results in increased expression of SLC2A3 mRNA | [108] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation4 |
tert-Butylhydroperoxide results in increased expression of SLC2A3 mRNA | [108] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation5 |
Troglitazone co-treated with tert-Butylhydroperoxide results in increased expression of SLC2A3 mRNA | [108] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation6 |
Troglitazone inhibits the reaction tert-Butylhydroperoxide results in increased expression of SLC2A3 mRNA | [108] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Tetrachlorodibenzodioxin |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Tetrachlorodibenzodioxin results in decreased expression of SLC2A3 mRNA | [113] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
trametinib |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
sotorasib co-treated with trametinib co-treated with NVP-BKM120 results in decreased expression of SLC2A3 mRNA | [100] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
tributyltin |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
tributyltin results in decreased expression of SLC2A3 mRNA | [35] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
trichostatin A |
3 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC2A3 mRNA | [48] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
trichostatin A affects the expression of SLC2A3 mRNA | [115] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation3 |
trichostatin A results in increased expression of SLC2A3 mRNA | [116] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
triphenyl phosphate |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
triphenyl phosphate affects the expression of SLC2A3 mRNA | [88] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Troglitazone |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Troglitazone co-treated with tert-Butylhydroperoxide results in increased expression of SLC2A3 mRNA | [108] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
Troglitazone inhibits the reaction tert-Butylhydroperoxide results in increased expression of SLC2A3 mRNA | [108] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
uranyl acetate |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
uranyl acetate affects the expression of SLC2A3 mRNA | [32] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Vanadates |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Vanadates results in increased expression of SLC2A3 mRNA | [117] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
vanadium pentoxide |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
vanadium pentoxide affects the expression of SLC2A3 mRNA | [118] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
vandetanib |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
vandetanib results in increased expression of SLC2A3 mRNA | [5] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
warangalone |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
warangalone analog results in decreased expression of SLC2A3 protein | [119] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Zinc |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
PCI 5002 co-treated with Zinc results in increased expression of SLC2A3 mRNA | [105] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
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