Detail Information of Exogenous Modulation

General Information of Drug Transporter (DT)
DT ID	DTD0230 Transporter Info
Gene Name	SLC26A2
Transporter Name	Sulfate transporter
Gene ID	1836
UniProt ID	P50443

Exogenous factors (drugs, dietary constituents, etc.) Modulation of This DT (EGM)
Chemical Compound
DT Modulation1	Progesterone co-treated with Estradiol results in increased expression of SLC26A2 mRNA		[3]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Valproic Acid affects the expression of SLC26A2 mRNA		[50]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Cyclosporine results in increased expression of SLC26A2 mRNA		[30]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Estradiol affects the expression of SLC26A2 mRNA		[44]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Estradiol co-treated with Tetrachlorodibenzodioxin results in decreased expression of SLC26A2 mRNA		[17]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	Estradiol co-treated with TGFB1 protein results in increased expression of SLC26A2 mRNA		[45]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	Estradiol results in increased expression of SLC26A2 mRNA		[2]
Regulation Mechanism			Transcription Factor Info
DT Modulation5	Progesterone co-treated with Estradiol results in increased expression of SLC26A2 mRNA		[3]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Benzo(a)pyrene results in increased methylation of SLC26A2 promoter		[33]
Regulation Mechanism			Transcription Factor Info
2,2',4,4'-tetrabromodiphenyl ether	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of SLC26A2 protein		[24]
Regulation Mechanism			Transcription Factor Info
2,4,6-tribromophenol	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	2,4,6-tribromophenol results in decreased expression of SLC26A2 mRNA		[24]
Regulation Mechanism			Transcription Factor Info
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SLC26A2 mRNA		[27]
Regulation Mechanism			Transcription Factor Info
abrine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	abrine results in decreased expression of SLC26A2 mRNA		[28]
Regulation Mechanism			Transcription Factor Info
afimoxifene	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	afimoxifene inhibits the reaction Estrogens results in increased expression of SLC26A2 mRNA		[29]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	afimoxifene results in decreased expression of SLC26A2 mRNA		[2]
Regulation Mechanism			Transcription Factor Info
aristolochic acid I	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	aristolochic acid I results in decreased expression of SLC26A2 mRNA		[31]
Regulation Mechanism			Transcription Factor Info
Cadmium Chloride	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Cadmium Chloride results in decreased expression of SLC26A2 mRNA		[35]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Cadmium Chloride results in increased abundance of Cadmium which results in increased expression of SLC26A2 mRNA		[34]
Regulation Mechanism			Transcription Factor Info
CGP 52608	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	CGP 52608 promotes the reaction RORA protein binds to SLC26A2 gene		[37]
Regulation Mechanism			Transcription Factor Info
cobaltous chloride	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	cobaltous chloride results in decreased expression of SLC26A2 mRNA		[38]
Regulation Mechanism			Transcription Factor Info
coumarin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	coumarin results in decreased phosphorylation of SLC26A2 protein		[36]
Regulation Mechanism			Transcription Factor Info
Coumestrol	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Coumestrol co-treated with ESR1 protein results in increased expression of SLC26A2 mRNA		[39]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Coumestrol co-treated with Resveratrol results in increased expression of SLC26A2 mRNA		[40]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	ESR2 protein affects the reaction Coumestrol co-treated with ESR1 protein results in increased expression of SLC26A2 mRNA		[39]
Regulation Mechanism			Transcription Factor Info
cupric chloride	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	cupric chloride results in increased expression of SLC26A2 mRNA		[35]
Regulation Mechanism			Transcription Factor Info
dimethylarsinous acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	dimethylarsinous acid results in decreased expression of SLC26A2 mRNA		[41]
Regulation Mechanism			Transcription Factor Info
di-n-butylphosphoric acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	di-n-butylphosphoric acid affects the expression of SLC26A2 mRNA		[42]
Regulation Mechanism			Transcription Factor Info
epigallocatechin gallate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	potassium chromate(VI) co-treated with epigallocatechin gallate results in decreased expression of SLC26A2 mRNA		[43]
Regulation Mechanism			Transcription Factor Info
Estrogens	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	afimoxifene inhibits the reaction Estrogens results in increased expression of SLC26A2 mRNA		[29]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Estrogens results in increased expression of SLC26A2 mRNA		[29]
Regulation Mechanism			Transcription Factor Info
FR900359	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	FR900359 affects the phosphorylation of SLC26A2 protein		[46]
Regulation Mechanism			Transcription Factor Info
lead acetate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	lead acetate results in decreased expression of SLC26A2 mRNA		[35]
Regulation Mechanism			Transcription Factor Info
Methotrexate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	SLC26A2 protein affects the susceptibility to Methotrexate		[47]
Regulation Mechanism			Transcription Factor Info
monomethylarsonous acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	monomethylarsonous acid results in decreased expression of SLC26A2 mRNA		[41]
Regulation Mechanism			Transcription Factor Info
nickel chloride	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	nickel chloride results in decreased expression of SLC26A2 mRNA		[15]
Regulation Mechanism			Transcription Factor Info
Okadaic Acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Okadaic Acid results in increased expression of SLC26A2 mRNA		[48]
Regulation Mechanism			Transcription Factor Info
PCI 5002	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	PCI 5002 results in increased expression of SLC26A2 mRNA		[16]
Regulation Mechanism			Transcription Factor Info
pirinixic acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	pirinixic acid binds to and results in increased activity of PPARA protein which results in decreased expression of SLC26A2 mRNA		[49]
Regulation Mechanism			Transcription Factor Info
potassium chromate(VI)	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	potassium chromate(VI) co-treated with epigallocatechin gallate results in decreased expression of SLC26A2 mRNA		[43]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	potassium chromate(VI) results in decreased expression of SLC26A2 mRNA		[43]
Regulation Mechanism			Transcription Factor Info
sodium arsenite	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	sodium arsenite results in decreased expression of SLC26A2 mRNA		[35]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	sodium arsenite results in increased abundance of Arsenic which results in decreased expression of SLC26A2 mRNA		[32]
Regulation Mechanism			Transcription Factor Info
sulforaphane	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	sulforaphane results in increased expression of SLC26A2 mRNA		[25]
Regulation Mechanism			Transcription Factor Info
tamibarotene	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	tamibarotene affects the expression of SLC26A2 mRNA		[1]
Regulation Mechanism			Transcription Factor Info
tetrabromobisphenol A	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	tetrabromobisphenol A results in decreased expression of SLC26A2 protein		[24]
Regulation Mechanism			Transcription Factor Info
Tetrachlorodibenzodioxin	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Estradiol co-treated with Tetrachlorodibenzodioxin results in decreased expression of SLC26A2 mRNA		[17]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Tetrachlorodibenzodioxin results in decreased expression of SLC26A2 mRNA		[17]
Regulation Mechanism			Transcription Factor Info
Thiram	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Thiram results in decreased expression of SLC26A2 mRNA		[35]
Regulation Mechanism			Transcription Factor Info
trichostatin A	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	trichostatin A results in increased expression of SLC26A2 mRNA		[7]
Regulation Mechanism			Transcription Factor Info
triphenyl phosphate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	triphenyl phosphate affects the expression of SLC26A2 mRNA		[42]
Regulation Mechanism			Transcription Factor Info
Vitamin K 3	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Vitamin K 3 affects the expression of SLC26A2 mRNA		[5]
Regulation Mechanism			Transcription Factor Info
Approved Drug
Fulvestrant	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Fulvestrant inhibits the expression of SLC26A2		[2]
Raloxifene Hydrochloride	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Raloxifene Hydrochloride inhibits the expression of SLC26A2		[2]
Progesterone	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Progesterone increases the expression of SLC26A2		[3]
Copper Sulfate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Copper Sulfate inhibits the expression of SLC26A2		[4]
Menadione	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Menadione affects the expression of SLC26A2		[5]
Zidovudine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Zidovudine increases the expression of SLC26A2		[6]
Valproic Acid	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Valproic Acid increases the expression of SLC26A2		[7]
Cyclosporine	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Cyclosporine inhibits the expression of SLC26A2		[8]
Rifampin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Rifampin inhibits the expression of SLC26A2		[9]
Urethane	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Urethane inhibits the expression of SLC26A2		[10]
Acetaminophen	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Acetaminophen increases the expression of SLC26A2		[11]
Tretinoin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Tretinoin inhibits the expression of SLC26A2		[12]
Estradiol	6 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Estradiol inhibits the expression of SLC26A2		[13]
Cisplatin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Cisplatin inhibits the expression of SLC26A2		[14]
Drug in Phase 2/3 Trial
AM-80	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	AM-80 affects the expression of SLC26A2		[1]
Drug in Phase 3 Trial
Afimoxifene	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Afimoxifene inhibits the expression of SLC26A2		[2]
Sulforafan	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Sulforafan increases the expression of SLC26A2		[25]
Drug in Phase 1 Trial
Quercetin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Quercetin inhibits the expression of SLC26A2		[18]
Trichostatin A	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Trichostatin A increases the expression of SLC26A2		[7]
Dihydrotestosterone	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Dihydrotestosterone increases the expression of SLC26A2		[22]
Investigative Drug
PCI-5002	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	PCI-5002 increases the expression of SLC26A2		[16]
Natural Product
Tobacco Smoke Pollution	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Tobacco Smoke Pollution inhibits the expression of SLC26A2		[21]
Caffeine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Caffeine results in increased phosphorylation of SLC26A2 protein		[36]
Regulation Mechanism			Transcription Factor Info
Resveratrol	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Coumestrol co-treated with Resveratrol results in increased expression of SLC26A2 mRNA		[40]
Regulation Mechanism			Transcription Factor Info
Environmental toxicant
Polychlorinated dibenzodioxin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Polychlorinated dibenzodioxin inhibits the expression of SLC26A2		[17]
Tetrabromobisphenol A	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Tetrabromobisphenol A inhibits the expression of SLC26A2		[24]
Mycotoxins
Aflatoxin M1	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Aflatoxin M1 inhibits the expression of SLC26A2		[23]
Aflatoxin B1	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Aflatoxin B1 increases the expression of SLC26A2		[26]
DT Modulation2	Aflatoxin B1 affects the expression of SLC26A2 protein		[30]
Regulation Mechanism			Transcription Factor Info
Acute Toxic Substance
Nickel chloride	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Nickel chloride inhibits the expression of SLC26A2		[15]
Cadmium	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Cadmium increases the expression of SLC26A2		[20]
Carcinogen
DT Modulation1	Cadmium Chloride results in increased abundance of Cadmium which results in increased expression of SLC26A2 mRNA		[34]
Regulation Mechanism			Transcription Factor Info
Benzo(a)pyrene	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Benzo(a)pyrene increases the expression of SLC26A2		[26]
Arsenic	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	sodium arsenite results in increased abundance of Arsenic which results in decreased expression of SLC26A2 mRNA		[32]
Regulation Mechanism			Transcription Factor Info
Herbicide
Atrazine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Atrazine increases the expression of SLC26A2		[19]

References
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Detail Information of Exogenous Modulation

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