Detail Information of Exogenous Modulation

General Information of Drug Transporter (DT)
DT ID	DTD0202 Transporter Info
Gene Name	SLC25A4
Transporter Name	Adenine nucleotide translocator 1
Gene ID	291
UniProt ID	P12235

Exogenous factors (drugs, dietary constituents, etc.) Modulation of This DT (EGM)
Chemical Compound
DT Modulation1	Testosterone co-treated with Calcitriol results in increased expression of SLC25A4 mRNA		[4]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased expression of SLC25A4 mRNA		[30]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Valproic Acid affects the expression of SLC25A4 mRNA		[46]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	Valproic Acid results in increased expression of SLC25A4 mRNA		[47]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Doxorubicin affects the expression of SLC25A4 protein		[39]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Testosterone co-treated with Calcitriol results in increased expression of SLC25A4 mRNA		[4]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Okadaic Acid results in increased expression of SLC25A4 mRNA		[42]
Regulation Mechanism			Transcription Factor Info
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	LDN 193189 co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with FGF2 protein results in decreased expression of SLC25A4 protein		[29]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased expression of SLC25A4 mRNA		[30]
Regulation Mechanism			Transcription Factor Info
Asbestos, Crocidolite	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Asbestos, Crocidolite results in increased expression of SLC25A4 mRNA		[33]
Regulation Mechanism			Transcription Factor Info
azoxystrobin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	azoxystrobin results in increased expression of SLC25A4 mRNA		[27]
Regulation Mechanism			Transcription Factor Info
beta-lapachone	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	beta-lapachone results in increased expression of SLC25A4 mRNA		[34]
Regulation Mechanism			Transcription Factor Info
bisphenol A	5 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	bisphenol A co-treated with Fulvestrant results in increased methylation of SLC25A4 gene		[35]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	bisphenol A results in decreased expression of SLC25A4 mRNA		[24]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	bisphenol A results in decreased expression of SLC25A4 protein		[29]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	bisphenol A results in increased expression of SLC25A4 protein		[28]
Regulation Mechanism			Transcription Factor Info
DT Modulation5	bisphenol A results in increased methylation of SLC25A4 gene		[35]
Regulation Mechanism			Transcription Factor Info
bisphenol AF	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	bisphenol AF results in increased expression of SLC25A4 protein		[28]
Regulation Mechanism			Transcription Factor Info
bisphenol B	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	bisphenol B results in increased expression of SLC25A4 protein		[28]
Regulation Mechanism			Transcription Factor Info
Cadmium Chloride	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Cadmium Chloride results in decreased expression of SLC25A4 mRNA		[36]
Regulation Mechanism			Transcription Factor Info
CD 437	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	CD 437 results in decreased activity of SLC25A4 protein		[20]
Regulation Mechanism			Transcription Factor Info
CGP 52608	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	CGP 52608 promotes the reaction RORA protein binds to SLC25A4 gene		[37]
Regulation Mechanism			Transcription Factor Info
closantel	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	closantel results in decreased activity of SLC25A4 protein		[20]
Regulation Mechanism			Transcription Factor Info
deguelin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	deguelin results in decreased expression of SLC25A4 mRNA		[27]
Regulation Mechanism			Transcription Factor Info
dehydroabietylamine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	dehydroabietylamine affects the activity of SLC25A4 protein		[20]
Regulation Mechanism			Transcription Factor Info
di-n-butylphosphoric acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	di-n-butylphosphoric acid affects the expression of SLC25A4 mRNA		[38]
Regulation Mechanism			Transcription Factor Info
dorsomorphin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased expression of SLC25A4 mRNA		[30]
Regulation Mechanism			Transcription Factor Info
Estradiol	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Estradiol co-treated with TGFB1 protein results in decreased expression of SLC25A4 mRNA		[40]
Regulation Mechanism			Transcription Factor Info
Fulvestrant	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	bisphenol A co-treated with Fulvestrant results in increased methylation of SLC25A4 gene		[35]
Regulation Mechanism			Transcription Factor Info
Isoniazid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Isoniazid results in increased expression of SLC25A4 protein		[41]
Regulation Mechanism			Transcription Factor Info
Lactic Acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Lactic Acid results in decreased expression of SLC25A4 mRNA		[26]
Regulation Mechanism			Transcription Factor Info
LDN 193189	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	LDN 193189 co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with FGF2 protein results in decreased expression of SLC25A4 protein		[29]
Regulation Mechanism			Transcription Factor Info
Manganese	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	sodium arsenite results in increased abundance of Arsenic co-treated with manganese chloride results in increased abundance of Manganese results in increased expression of SLC25A4 mRNA		[32]
Regulation Mechanism			Transcription Factor Info
manganese chloride	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	sodium arsenite results in increased abundance of Arsenic co-treated with manganese chloride results in increased abundance of Manganese results in increased expression of SLC25A4 mRNA		[32]
Regulation Mechanism			Transcription Factor Info
perfluorooctanoic acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	perfluorooctanoic acid results in increased expression of SLC25A4 protein		[43]
Regulation Mechanism			Transcription Factor Info
pyrachlostrobin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	pyrachlostrobin results in increased expression of SLC25A4 mRNA		[27]
Regulation Mechanism			Transcription Factor Info
S-(1,2-dichlorovinyl)cysteine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	S-(1,2-dichlorovinyl)cysteine affects the susceptibility to Lipopolysaccharides which results in increased expression of SLC25A4 mRNA		[44]
Regulation Mechanism			Transcription Factor Info
sodium arsenate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	sodium arsenate results in increased abundance of Arsenic which results in increased expression of SLC25A4 mRNA		[31]
Regulation Mechanism			Transcription Factor Info
sodium arsenite	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	sodium arsenite results in increased abundance of Arsenic co-treated with manganese chloride results in increased abundance of Manganese results in increased expression of SLC25A4 mRNA		[32]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	sodium arsenite results in increased abundance of Arsenic which results in increased expression of SLC25A4 mRNA		[32]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	sodium arsenite results in increased expression of SLC25A4 mRNA		[36]
Regulation Mechanism			Transcription Factor Info
Tretinoin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	SLC25A4 protein results in increased susceptibility to Tretinoin		[45]
Regulation Mechanism			Transcription Factor Info
trichostatin A	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	trichostatin A affects the expression of SLC25A4 mRNA		[22]
Regulation Mechanism			Transcription Factor Info
Carcinogen
Arsenic	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	sodium arsenate results in increased abundance of Arsenic which results in increased expression of SLC25A4 mRNA		[31]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	sodium arsenite results in increased abundance of Arsenic co-treated with manganese chloride results in increased abundance of Manganese results in increased expression of SLC25A4 mRNA		[32]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	sodium arsenite results in increased abundance of Arsenic which results in increased expression of SLC25A4 mRNA		[32]
Regulation Mechanism			Transcription Factor Info
Approved Drug
Paclitaxel	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Paclitaxel inhibits the expression of SLC25A4		[1]
Copper Sulfate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Copper Sulfate inhibits the expression of SLC25A4		[2]
Cyclosporine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Cyclosporine inhibits the expression of SLC25A4		[3]
Testosterone	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Testosterone increases the expression of SLC25A4		[4]
Arsenic Trioxide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Arsenic Trioxide increases the expression of SLC25A4		[5]
Acetaminophen	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Acetaminophen increases the expression of SLC25A4		[6]
Valproic Acid	4 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Valproic Acid inhibits the expression of SLC25A4		[7]
Menthol	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Menthol inhibits the expression of SLC25A4		[8]
Folic Acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Folic Acid affects the expression of SLC25A4		[9]
Dronabinol	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Dronabinol inhibits the expression of SLC25A4		[10]
Doxorubicin	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Doxorubicin increases the expression of SLC25A4		[11]
Temozolomide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Temozolomide increases the expression of SLC25A4		[12]
Ivermectin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Ivermectin inhibits the expression of SLC25A4		[13]
Calcitriol	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Calcitriol increases the expression of SLC25A4		[4]
Drug in Phase 3 Trial
Vitamin E	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Vitamin E increases the expression of SLC25A4		[14]
Triclosan	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Triclosan inhibits the expression of SLC25A4		[25]
Drug in Phase 2 Trial
Bisphenol A	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Bisphenol A inhibits the expression of SLC25A4		[24]
Bisphenol B	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Bisphenol B increases the expression of SLC25A4		[28]
Drug in Phase 1 Trial
Trichostatin A	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Trichostatin A affects the expression of SLC25A4		[22]
Drug in Preclinical Test
(+)-JQ1	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	(+)-JQ1 increases the expression of SLC25A4		[18]
Investigative Drug
Milchsaure	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Milchsaure inhibits the expression of SLC25A4		[26]
Natural Product
Thapsigargin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Thapsigargin inhibits the expression of SLC25A4		[15]
Deguelin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Deguelin inhibits the expression of SLC25A4		[27]
Acute Toxic Substance
Okadaic Acid	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Okadaic Acid affects the expression of SLC25A4		[16]
Cadmium	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Cadmium increases the expression of SLC25A4		[17]
Formaldehyde	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Formaldehyde inhibits the expression of SLC25A4		[21]
Antimycin A	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Antimycin A inhibits the expression of SLC25A4		[27]
Fungicide
Azoxystrobin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Azoxystrobin increases the expression of SLC25A4		[27]
Health and Environmental Toxicant
tris(1,3-dichloro-2-propyl)phosphate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	tris(1,3-dichloro-2-propyl)phosphate inhibits the expression of SLC25A4		[19]
CD-437	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	CD-437 inhibits the activity of SLC25A4		[20]
Lead	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Lead affects the expression of SLC25A4		[23]
Herbicide
Atrazine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Atrazine inhibits the expression of SLC25A4		[15]

References
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Detail Information of Exogenous Modulation

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