General Information of Drug Transporter (DT)
DT ID DTD0180 Transporter Info
Gene Name SLC25A20
Transporter Name Carnitine/acylcarnitine translocase
Gene ID
788
UniProt ID
O43772
Exogenous factors (drugs, dietary constituents, etc.) Modulation of This DT (EGM)

Chemical Compound

  DT Modulation1

Testosterone co-treated with Calcitriol results in increased expression of SLC25A20 mRNA [4]

Regulation Mechanism

Transcription Factor Info

  DT Modulation1

NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC25A20 mRNA [28]

Regulation Mechanism

Transcription Factor Info

  DT Modulation2

Valproic Acid affects the expression of SLC25A20 mRNA [45]

Regulation Mechanism

Transcription Factor Info

  DT Modulation3

Valproic Acid results in increased expression of SLC25A20 mRNA [46]

Regulation Mechanism

Transcription Factor Info

  DT Modulation4

Valproic Acid results in increased methylation of SLC25A20 gene [9]

Regulation Mechanism

Transcription Factor Info

  DT Modulation1

Testosterone co-treated with Calcitriol results in increased expression of SLC25A20 mRNA [4]

Regulation Mechanism

Transcription Factor Info

  DT Modulation1

Acetylcysteine inhibits the reaction Mercuric Chloride results in decreased activity of SLC25A20 protein [1]

Regulation Mechanism

Transcription Factor Info

  DT Modulation2

Dithioerythritol inhibits the reaction Mercuric Chloride results in decreased activity of SLC25A20 protein [1]

Regulation Mechanism

Transcription Factor Info

  DT Modulation3

Glutathione inhibits the reaction Mercuric Chloride results in decreased activity of SLC25A20 protein [1]

Regulation Mechanism

Transcription Factor Info

  DT Modulation4

Mercuric Chloride results in decreased activity of SLC25A20 protein [1]

Regulation Mechanism

Transcription Factor Info

  DT Modulation1

NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC25A20 mRNA [28]

Regulation Mechanism

Transcription Factor Info

  2,5,2',5'-tetrachlorobiphenyl

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

2,5,2',5'-tetrachlorobiphenyl results in decreased expression of SLC25A20 mRNA [27]

Regulation Mechanism

Transcription Factor Info

  4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide

           2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC25A20 mRNA [28]

Regulation Mechanism

Transcription Factor Info

  DT Modulation2

NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC25A20 mRNA [28]

Regulation Mechanism

Transcription Factor Info

  Acetylcysteine

           2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Acetylcysteine inhibits the reaction Mercuric Chloride results in decreased activity of SLC25A20 protein [1]

Regulation Mechanism

Transcription Factor Info

  DT Modulation2

Acetylcysteine inhibits the reaction methylmercuric chloride results in decreased activity of SLC25A20 protein [1]

Regulation Mechanism

Transcription Factor Info

  aristolochic acid I

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

aristolochic acid I results in increased expression of SLC25A20 mRNA [30]

Regulation Mechanism

Transcription Factor Info

  benzo(e)pyrene

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

benzo(e)pyrene results in decreased methylation of SLC25A20 intron [29]

Regulation Mechanism

Transcription Factor Info

  bisphenol AF

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

bisphenol AF results in increased expression of SLC25A20 protein [26]

Regulation Mechanism

Transcription Factor Info

  bisphenol B

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

bisphenol B results in increased expression of SLC25A20 protein [26]

Regulation Mechanism

Transcription Factor Info

  bisphenol F

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

bisphenol F results in increased expression of SLC25A20 protein [26]

Regulation Mechanism

Transcription Factor Info

  Cadmium Chloride

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Cadmium Chloride results in increased abundance of Cadmium which results in increased expression of SLC25A20 mRNA [32]

Regulation Mechanism

Transcription Factor Info

  chloroacetaldehyde

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

chloroacetaldehyde results in increased expression of SLC25A20 mRNA [6]

Regulation Mechanism

Transcription Factor Info

  chromium hexavalent ion

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

chromium hexavalent ion results in decreased expression of SLC25A20 mRNA [33]

Regulation Mechanism

Transcription Factor Info

  dicrotophos

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

dicrotophos results in decreased expression of SLC25A20 mRNA [19]

Regulation Mechanism

Transcription Factor Info

  di-n-butylphosphoric acid

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

di-n-butylphosphoric acid affects the expression of SLC25A20 mRNA [34]

Regulation Mechanism

Transcription Factor Info

  Dithioerythritol

           2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Dithioerythritol inhibits the reaction Mercuric Chloride results in decreased activity of SLC25A20 protein [1]

Regulation Mechanism

Transcription Factor Info

  DT Modulation2

Dithioerythritol inhibits the reaction methylmercuric chloride results in decreased activity of SLC25A20 protein [1]

Regulation Mechanism

Transcription Factor Info

  Diuron

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Diuron results in decreased expression of SLC25A20 mRNA [35]

Regulation Mechanism

Transcription Factor Info

  dorsomorphin

           2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC25A20 mRNA [28]

Regulation Mechanism

Transcription Factor Info

  DT Modulation2

NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC25A20 mRNA [28]

Regulation Mechanism

Transcription Factor Info

  epigallocatechin gallate

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

potassium chromate(VI) co-treated with epigallocatechin gallate results in decreased expression of SLC25A20 mRNA [36]

Regulation Mechanism

Transcription Factor Info

  Farnesol

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Farnesol analog co-treated with Oleic Acid results in increased expression of SLC25A20 mRNA [23]

Regulation Mechanism

Transcription Factor Info

  fenofibric acid

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

fenofibric acid binds to PPARA protein which results in increased expression of SLC25A20 mRNA [37]

Regulation Mechanism

Transcription Factor Info

  FR900359

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

FR900359 results in increased phosphorylation of SLC25A20 protein [38]

Regulation Mechanism

Transcription Factor Info

  Glutathione

           2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Glutathione inhibits the reaction Mercuric Chloride results in decreased activity of SLC25A20 protein [1]

Regulation Mechanism

Transcription Factor Info

  DT Modulation2

Glutathione inhibits the reaction methylmercuric chloride results in decreased activity of SLC25A20 protein [1]

Regulation Mechanism

Transcription Factor Info

  glycidyl methacrylate

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

glycidyl methacrylate results in decreased expression of SLC25A20 protein [39]

Regulation Mechanism

Transcription Factor Info

  GW 4064

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

GW 4064 co-treated with Oleic Acid results in decreased expression of SLC25A20 mRNA [23]

Regulation Mechanism

Transcription Factor Info

  GW 7647

           2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

GW 7647 co-treated with Oleic Acid results in increased expression of SLC25A20 mRNA [23]

Regulation Mechanism

Transcription Factor Info

  DT Modulation2

GW 7647 results in increased expression of SLC25A20 mRNA [23]

Regulation Mechanism

Transcription Factor Info

  Methapyrilene

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Methapyrilene results in decreased methylation of SLC25A20 intron [29]

Regulation Mechanism

Transcription Factor Info

  methylmercuric chloride

           4 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Acetylcysteine inhibits the reaction methylmercuric chloride results in decreased activity of SLC25A20 protein [1]

Regulation Mechanism

Transcription Factor Info

  DT Modulation2

Dithioerythritol inhibits the reaction methylmercuric chloride results in decreased activity of SLC25A20 protein [1]

Regulation Mechanism

Transcription Factor Info

  DT Modulation3

Glutathione inhibits the reaction methylmercuric chloride results in decreased activity of SLC25A20 protein [1]

Regulation Mechanism

Transcription Factor Info

  DT Modulation4

methylmercuric chloride results in decreased activity of SLC25A20 protein [1]

Regulation Mechanism

Transcription Factor Info

  Okadaic Acid

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Okadaic Acid results in decreased expression of SLC25A20 mRNA [41]

Regulation Mechanism

Transcription Factor Info

  Oleic Acid

           3 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Farnesol analog co-treated with Oleic Acid results in increased expression of SLC25A20 mRNA [23]

Regulation Mechanism

Transcription Factor Info

  DT Modulation2

GW 4064 co-treated with Oleic Acid results in decreased expression of SLC25A20 mRNA [23]

Regulation Mechanism

Transcription Factor Info

  DT Modulation3

GW 7647 co-treated with Oleic Acid results in increased expression of SLC25A20 mRNA [23]

Regulation Mechanism

Transcription Factor Info

  Oxygen

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Oxygen deficiency results in decreased expression of SLC25A20 mRNA [6]

Regulation Mechanism

Transcription Factor Info

  perfluorododecanoic acid

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

perfluorododecanoic acid results in decreased expression of SLC25A20 mRNA [16]

Regulation Mechanism

Transcription Factor Info

  perfluorooctanoic acid

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

perfluorooctanoic acid results in increased expression of SLC25A20 mRNA [42]

Regulation Mechanism

Transcription Factor Info

  potassium chromate(VI)

           2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

potassium chromate(VI) co-treated with epigallocatechin gallate results in decreased expression of SLC25A20 mRNA [36]

Regulation Mechanism

Transcription Factor Info

  DT Modulation2

potassium chromate(VI) results in decreased expression of SLC25A20 mRNA [36]

Regulation Mechanism

Transcription Factor Info

  S-(1,2-dichlorovinyl)cysteine

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

S-(1,2-dichlorovinyl)cysteine affects the susceptibility to Lipopolysaccharides which results in increased expression of SLC25A20 mRNA [43]

Regulation Mechanism

Transcription Factor Info

  sodium arsenite

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

sodium arsenite results in increased expression of SLC25A20 mRNA [44]

Regulation Mechanism

Transcription Factor Info

  Tetrachlorodibenzodioxin

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Tetrachlorodibenzodioxin results in increased expression of SLC25A20 mRNA [3]

Regulation Mechanism

Transcription Factor Info

  trichostatin A

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

trichostatin A affects the expression of SLC25A20 mRNA [20]

Regulation Mechanism

Transcription Factor Info

Mycotoxins

  aflatoxin B2

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

aflatoxin B2 results in decreased methylation of SLC25A20 intron [29]

Regulation Mechanism

Transcription Factor Info

Approved Drug

  Copper Sulfate

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Copper Sulfate inhibits the expression of SLC25A20 [2]

  Estradiol

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Estradiol inhibits the expression of SLC25A20 [3]

  Testosterone

           2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Testosterone increases the expression of SLC25A20 [4]

  Zidovudine

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Zidovudine increases the expression of SLC25A20 [5]

  Cidofovir

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Cidofovir increases the expression of SLC25A20 [6]

  Ifosfamide

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Ifosfamide increases the expression of SLC25A20 [6]

  Rosiglitazone

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Rosiglitazone inhibits the expression of SLC25A20 [6]

  Urethane

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Urethane inhibits the expression of SLC25A20 [7]

  Acetaminophen

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Acetaminophen inhibits the expression of SLC25A20 [8]

  Valproic Acid

           5 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Valproic Acid inhibits the expression of SLC25A20 [9]

  Sunitinib

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Sunitinib inhibits the expression of SLC25A20 [10]

  Tretinoin

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Tretinoin increases the expression of SLC25A20 [11]

  Cyclosporine

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Cyclosporine inhibits the expression of SLC25A20 [6]

  Calcitriol

           2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Calcitriol increases the expression of SLC25A20 [12]

  Fenofibrate

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Fenofibrate increases the expression of SLC25A20 [6]

  Cisplatin

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Cisplatin increases the expression of SLC25A20 [13]

Drug Marketed but not Approved by US FDA

  Clodronic Acid

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Clodronic Acid increases the expression of SLC25A20 [6]

Drug in Phase 2 Trial

  Bisphenol B

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Bisphenol B increases the expression of SLC25A20 [26]

Drug in Phase 1 Trial

  Quercetin

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Quercetin inhibits the expression of SLC25A20 [14]

  Trichostatin A

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Trichostatin A affects the expression of SLC25A20 [20]

  Dihydrotestosterone

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Dihydrotestosterone increases the expression of SLC25A20 [22]

Drug in Preclinical Test

  Perfluorododecanoic acid

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Perfluorododecanoic acid inhibits the expression of SLC25A20 [16]

Investigative Drug

  Phenylmercuric Acetate

           2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Phenylmercuric Acetate increases the expression of SLC25A20 [18]

Patented Pharmaceutical Agent

  GSK-J4

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

GSK-J4 inhibits the expression of SLC25A20 [21]

  GW-7647

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

GW-7647 increases the expression of SLC25A20 [23]

Natural Product

  Thapsigargin

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Thapsigargin increases the expression of SLC25A20 [15]

  Tobacco Smoke Pollution

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Tobacco Smoke Pollution increases the expression of SLC25A20 [25]

Environmental toxicant

  Mercury ion

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Mercury ion inhibits the activity of SLC25A20 (IC50 = 90 microM) [1]

Cell System

Human cervical cancer cell line (Hela)-CACT

  Methyl mercury ion

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Methyl mercury ion inhibits the activity of SLC25A20 (IC50 = 1237 microM) [1]

Cell System

Human cervical cancer cell line (Hela)-CACT

  Polychlorinated dibenzodioxin

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Polychlorinated dibenzodioxin increases the expression of SLC25A20 [3]

  Bisphenol F

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Bisphenol F increases the expression of SLC25A20 [26]

Acute Toxic Substance

  Mercuric Chloride

           5 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Mercuric Chloride inhibits the activity of SLC25A20 [1]

Carcinogen

  Benzo(a)pyrene

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Benzo(a)pyrene inhibits the expression of SLC25A20 [24]

  Arsenic

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Arsenic affects the methylation of SLC25A20 gene [31]

Regulation Mechanism

Transcription Factor Info

  Cadmium

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Cadmium Chloride results in increased abundance of Cadmium which results in increased expression of SLC25A20 mRNA [32]

Regulation Mechanism

Transcription Factor Info

  Nickel

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Nickel results in decreased expression of SLC25A20 mRNA [40]

Regulation Mechanism

Transcription Factor Info

Pesticide/Insecticide

  Dicrotophos

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

Dicrotophos inhibits the expression of SLC25A20 [19]

Health and Environmental Toxicant

  tris(1,3-dichloro-2-propyl)phosphate

           1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

tris(1,3-dichloro-2-propyl)phosphate inhibits the expression of SLC25A20 [17]
References
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2 Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper. Physiol Genomics. 2009 Aug 7;38(3):386-401.
3 Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
4 Effects of 1alpha,25 dihydroxyvitamin D3 and testosterone on miRNA and mRNA expression in LNCaP cells. Mol Cancer. 2011 May 18;10:58.
5 Differential gene expression in human hepatocyte cell lines exposed to the antiretroviral agent zidovudine. Arch Toxicol. 2014 Mar;88(3):609-23.
6 Transcriptomics hit the target: Monitoring of ligand-activated and stress response pathways for chemical testing. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):7-18.
7 Ethyl carbamate induces cell death through its effects on multiple metabolic pathways. Chem Biol Interact. 2017 Nov 1;277:21-32.
8 Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans. Arch Toxicol. 2018 Feb;92(2):845-858.
9 Integrated 'omics analysis reveals new drug-induced mitochondrial perturbations in human hepatocytes. Toxicol Lett. 2018 Jun 1;289:1-13.
10 Cell-based two-dimensional morphological assessment system to predict cancer drug-induced cardiotoxicity using human induced pluripotent stem cell-derived cardiomyocytes. Toxicol Appl Pharmacol. 2019 Nov 15;383:114761.
11 Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423.
12 Vitamin D3 transactivates the zinc and manganese transporter SLC30A10 via the Vitamin D receptor. J Steroid Biochem Mol Biol. 2016 Oct;163:77-87.
13 Activation of AIFM2 enhances apoptosis of human lung cancer cells undergoing toxicological stress. Toxicol Lett. 2016 Sep 6;258:227-236.
14 Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
15 Endoplasmic reticulum stress impairs insulin signaling through mitochondrial damage in SH-SY5Y cells. Neurosignals. 2012;20(4):265-80.
16 Evaluation of perfluoroalkyl acid activity using primary mouse and human hepatocytes. Toxicology. 2013 Jun 7;308:129-37.
17 Defensive and adverse energy-related molecular responses precede tris (1, 3-dichloro-2-propyl) phosphate cytotoxicity. J Appl Toxicol. 2016 May;36(5):649-58.
18 A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors. Arch Toxicol. 2015 Sep;89(9):1599-618.
19 Molecular mechanisms of discrotophos-induced toxicity in HepG2 cells: The role of CSA in oxidative stress. Food Chem Toxicol. 2017 May;103:253-260.
20 A trichostatin A expression signature identified by TempO-Seq targeted whole transcriptome profiling. PLoS One. 2017 May 25;12(5):e0178302.
21 Inhibition of histone H3K27 demethylases selectively modulates inflammatory phenotypes of natural killer cells. J Biol Chem. 2018 Feb 16;293(7):2422-2437.
22 LSD1 activates a lethal prostate cancer gene network independently of its demethylase function. Proc Natl Acad Sci U S A. 2018 May 1;115(18):E4179-E4188.
23 Farnesol induces fatty acid oxidation and decreases triglyceride accumulation in steatotic HepaRG cells. Toxicol Appl Pharmacol. 2019 Feb 15;365:61-70.
24 Identification of a transcriptomic signature of food-relevant genotoxins in human HepaRG hepatocarcinoma cells. Food Chem Toxicol. 2020 Jun;140:111297.
25 Integration of transcriptome analysis with pathophysiological endpoints to evaluate cigarette smoke toxicity in an in vitro human airway tissue model. Arch Toxicol. 2021 May;95(5):1739-1761.
26 Alternatives for the worse: Molecular insights into adverse effects of bisphenol a and substitutes during human adipocyte differentiation. Environ Int. 2021 Nov;156:106730.
27 Hydroxylation markedly alters how the polychlorinated biphenyl (PCB) congener, PCB52, affects gene expression in human preadipocytes. Toxicol In Vitro. 2023;89:105568.
28 Definition of transcriptome-based indices for quantitative characterization of chemically disturbed stem cell development: introduction of the STOP-Toxukn and STOP-Toxukk tests. Arch Toxicol. 2017 Feb;91(2):839-864.
29 Effect of aflatoxin B(1), benzo[a]pyrene, and methapyrilene on transcriptomic and epigenetic alterations in human liver HepaRG cells. Food Chem Toxicol. 2018;121:214-223.
30 Integration of transcriptomic, proteomic and metabolomic data to reveal the biological mechanisms of AAI injury in renal epithelial cells. Toxicol In Vitro. 2021;70:105054.
31 Prenatal arsenic exposure and the epigenome: identifying sites of 5-methylcytosine alterations that predict functional changes in gene expression in newborn cord blood and subsequent birth outcomes. Toxicol Sci. 2015 Jan;143(1):97-106.
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