Detail Information of Exogenous Modulation

General Information of Drug Transporter (DT)
DT ID DTD0179 Transporter Info
Gene Name SLC25A2
Transporter Name Mitochondrial ornithine transporter 2
Gene ID
83884
UniProt ID
Q9BXI2
Exogenous factors (drugs, dietary constituents, etc.) Modulation of This DT (EGM)

Chemical Compound

  aristolochic acid I

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 aristolochic acid I results in increased expression of SLC25A2 mRNA [4]

Regulation Mechanism

 Transcription Factor Info

  Benzo(a)pyrene

            2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Benzo(a)pyrene affects the methylation of SLC25A2 exon [5]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation2

 Benzo(a)pyrene affects the methylation of SLC25A2 promoter [5]

Regulation Mechanism

 Transcription Factor Info

  epigallocatechin gallate

            2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 epigallocatechin gallate results in increased expression of SLC25A2 mRNA [3]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation2

 potassium chromate(VI) co-treated with epigallocatechin gallate results in increased expression of SLC25A2 mRNA [3]

Regulation Mechanism

 Transcription Factor Info

  kojic acid

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 kojic acid results in decreased expression of SLC25A2 mRNA [2]

Regulation Mechanism

 Transcription Factor Info

  Levonorgestrel

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 testosterone undecanoate co-treated with Levonorgestrel results in increased expression of SLC25A2 mRNA [6]

Regulation Mechanism

 Transcription Factor Info

  mivebresib

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 mivebresib results in increased expression of SLC25A2 mRNA [7]

Regulation Mechanism

 Transcription Factor Info

  pirinixic acid

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 pirinixic acid binds to and results in increased activity of PPARA protein which results in decreased expression of SLC25A2 mRNA [8]

Regulation Mechanism

 Transcription Factor Info

  potassium chromate(VI)

            2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 potassium chromate(VI) co-treated with epigallocatechin gallate results in increased expression of SLC25A2 mRNA [3]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation2

 potassium chromate(VI) results in increased expression of SLC25A2 mRNA [3]

Regulation Mechanism

 Transcription Factor Info

  testosterone undecanoate

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 testosterone undecanoate co-treated with Levonorgestrel results in increased expression of SLC25A2 mRNA [6]

Regulation Mechanism

 Transcription Factor Info

Drug Marketed but not Approved by US FDA

  Arbutin

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Arbutin inhibits the expression of SLC25A2 [1]

Drug in Phase 3 Trial

  Epigallocatechin gallate

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Epigallocatechin gallate increases the expression of SLC25A2 [3]

Health and Environmental Toxicant

  Kojic acid

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Kojic acid inhibits the expression of SLC25A2 [2]
References
1 Toxicogenomics of A375 human malignant melanoma cells treated with arbutin. J Biomed Sci. 2007 Jan;14(1):87-105.
2 Toxicogenomics of kojic acid on gene expression profiling of a375 human malignant melanoma cells. Biol Pharm Bull. 2006 Apr;29(4):655-69.
3 Epigallocatechin-3-gallate (EGCG) protects against chromate-induced toxicity in vitro. Toxicol Appl Pharmacol. 2012 Jan 15;258(2):166-75.
4 Integration of transcriptomic, proteomic and metabolomic data to reveal the biological mechanisms of AAI injury in renal epithelial cells. Toxicol In Vitro. 2021;70:105054.
5 Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017;8(1):1369-1391.
6 Levonorgestrel enhances spermatogenesis suppression by testosterone with greater alteration in testicular gene expression in men. Biol Reprod. 2009 Mar;80(3):484-92.
7 Comprehensive transcriptome profiling of BET inhibitor-treated HepG2 cells. PLoS One. 2022;17(4):e0266966.
8 Comparative analysis of gene regulation by the transcription factor PPARalpha between mouse and human. PLoS One. 2009;4(8):e6796.

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