Detail Information of Exogenous Modulation

General Information of Drug Transporter (DT)
DT ID	DTD0151 Transporter Info
Gene Name	SLC22A4
Transporter Name	Organic cation/carnitine transporter 1
Gene ID	6583
UniProt ID	Q9H015

Exogenous factors (drugs, dietary constituents, etc.) Modulation of This DT (EGM)
Chemical Compound
DT Modulation1	Verapamil inhibits the reaction SLC22A4 protein results in increased uptake of Tetraethylammonium			[31]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Ergothioneine inhibits the reaction SLC22A4 protein results in increased abundance of Doxorubicin			[36]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Metformin inhibits the reaction SLC22A4 protein results in increased abundance of Doxorubicin			[36]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	SLC22A4 protein results in increased abundance of Doxorubicin			[36]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Estradiol co-treated with Tetrachlorodibenzodioxin results in increased expression of SLC22A4 mRNA			[37]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Estradiol co-treated with TGFB1 protein results in increased expression of SLC22A4 mRNA			[38]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Tetrachlorodibenzodioxin co-treated with Cycloheximide results in increased expression of SLC22A4 mRNA			[16]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Thimerosal results in decreased activity of SLC22A4 protein			[19]
Regulation Mechanism				Transcription Factor Info
abrine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	abrine results in increased expression of SLC22A4 mRNA			[27]
Regulation Mechanism				Transcription Factor Info
Acetylcysteine	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Acetylcysteine inhibits the reaction Mercury results in decreased activity of SLC22A4 protein			[19]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Acetylcysteine inhibits the reaction methylmercuric chloride results in decreased activity of SLC22A4 protein			[19]
Regulation Mechanism				Transcription Factor Info
aristolochic acid I	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	aristolochic acid I results in increased expression of SLC22A4 mRNA			[29]
Regulation Mechanism				Transcription Factor Info
Asbestos, Serpentine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Asbestos, Serpentine results in increased expression of SLC22A4 mRNA			[30]
Regulation Mechanism				Transcription Factor Info
Atropine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Atropine inhibits the reaction SLC22A4 protein results in increased uptake of Tetraethylammonium			[31]
Regulation Mechanism				Transcription Factor Info
bisphenol A	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	bisphenol A results in increased expression of SLC22A4 mRNA			[23]
Regulation Mechanism				Transcription Factor Info
Carnitine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLC22A4 protein results in increased uptake of Carnitine			[32]
Regulation Mechanism				Transcription Factor Info
Carvedilol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Carvedilol inhibits the reaction SLC22A4 protein results in increased uptake of Tetraethylammonium			[31]
Regulation Mechanism				Transcription Factor Info
CGP 52608	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	CGP 52608 promotes the reaction RORA protein binds to SLC22A4 gene			[33]
Regulation Mechanism				Transcription Factor Info
cupric chloride	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	cupric chloride results in increased expression of SLC22A4 mRNA			[34]
Regulation Mechanism				Transcription Factor Info
Cysteine	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cysteine inhibits the reaction Mercury results in decreased activity of SLC22A4 protein			[19]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Cysteine inhibits the reaction methylmercuric chloride results in decreased activity of SLC22A4 protein			[19]
Regulation Mechanism				Transcription Factor Info
Diltiazem	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Diltiazem inhibits the reaction SLC22A4 protein results in increased uptake of Tetraethylammonium			[31]
Regulation Mechanism				Transcription Factor Info
di-n-butylphosphoric acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	di-n-butylphosphoric acid affects the expression of SLC22A4 mRNA			[35]
Regulation Mechanism				Transcription Factor Info
Dithioerythritol	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Dithioerythritol inhibits the reaction Cadmium results in decreased activity of SLC22A4 protein			[19]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Dithioerythritol inhibits the reaction Mercury results in decreased activity of SLC22A4 protein			[19]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Dithioerythritol inhibits the reaction methylmercuric chloride results in decreased activity of SLC22A4 protein			[19]
Regulation Mechanism				Transcription Factor Info
Ergothioneine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ergothioneine inhibits the reaction SLC22A4 protein results in increased abundance of Doxorubicin			[36]
Regulation Mechanism				Transcription Factor Info
Flecainide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Flecainide inhibits the reaction SLC22A4 protein results in increased uptake of Tetraethylammonium			[31]
Regulation Mechanism				Transcription Factor Info
Hydroxyurea	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLC22A4 protein results in increased uptake of Hydroxyurea			[32]
Regulation Mechanism				Transcription Factor Info
Ipratropium	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ipratropium inhibits the reaction SLC22A4 protein results in increased uptake of Tetraethylammonium			[31]
Regulation Mechanism				Transcription Factor Info
lead acetate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	lead acetate results in increased expression of SLC22A4 mRNA			[34]
Regulation Mechanism				Transcription Factor Info
Lidocaine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Lidocaine inhibits the reaction SLC22A4 protein results in increased uptake of Tetraethylammonium			[31]
Regulation Mechanism				Transcription Factor Info
methanethiosulfonate ethylammonium	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	methanethiosulfonate ethylammonium results in decreased activity of SLC22A4 protein			[19]
Regulation Mechanism				Transcription Factor Info
methylmercuric chloride	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Acetylcysteine inhibits the reaction methylmercuric chloride results in decreased activity of SLC22A4 protein			[19]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Cysteine inhibits the reaction methylmercuric chloride results in decreased activity of SLC22A4 protein			[19]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Dithioerythritol inhibits the reaction methylmercuric chloride results in decreased activity of SLC22A4 protein			[19]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	methylmercuric chloride binds to and results in decreased activity of SLC22A4 protein			[19]
Regulation Mechanism				Transcription Factor Info
Nifedipine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Nifedipine inhibits the reaction SLC22A4 protein results in increased uptake of Tetraethylammonium			[31]
Regulation Mechanism				Transcription Factor Info
Oxaliplatin	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLC22A4 protein results in increased import of Oxaliplatin			[39]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	SLC22A4 protein results in increased susceptibility to Oxaliplatin			[39]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	tetrahydropalmatine inhibits the reaction SLC22A4 protein results in increased import of Oxaliplatin			[39]
Regulation Mechanism				Transcription Factor Info
Ozone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Air Pollutants results in increased abundance of Ozone which affects the expression of SLC22A4 mRNA			[40]
Regulation Mechanism				Transcription Factor Info
perfluorooctane sulfonic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	perfluorooctane sulfonic acid results in increased expression of SLC22A4 mRNA			[20]
Regulation Mechanism				Transcription Factor Info
perfluorooctanoic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	perfluorooctanoic acid results in increased expression of SLC22A4 mRNA			[20]
Regulation Mechanism				Transcription Factor Info
pirinixic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	pirinixic acid binds to and results in increased activity of PPARA protein which results in decreased expression of SLC22A4 mRNA			[41]
Regulation Mechanism				Transcription Factor Info
Propafenone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Propafenone inhibits the reaction SLC22A4 protein results in increased uptake of Tetraethylammonium			[31]
Regulation Mechanism				Transcription Factor Info
Propranolol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Propranolol inhibits the reaction SLC22A4 protein results in increased uptake of Tetraethylammonium			[31]
Regulation Mechanism				Transcription Factor Info
Silicon Dioxide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Silicon Dioxide analog results in increased expression of SLC22A4 mRNA			[42]
Regulation Mechanism				Transcription Factor Info
Sodium Dodecyl Sulfate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sodium Dodecyl Sulfate results in increased expression of SLC22A4 mRNA			[43]
Regulation Mechanism				Transcription Factor Info
Spironolactone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Spironolactone inhibits the reaction SLC22A4 protein results in increased uptake of Tetraethylammonium			[31]
Regulation Mechanism				Transcription Factor Info
Tetrachlorodibenzodioxin	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction Tetrachlorodibenzodioxin results in increased expression of SLC22A4 mRNA			[24]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Estradiol co-treated with Tetrachlorodibenzodioxin results in increased expression of SLC22A4 mRNA			[37]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Tetrachlorodibenzodioxin co-treated with Cycloheximide results in increased expression of SLC22A4 mRNA			[16]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Tetrachlorodibenzodioxin results in increased expression of SLC22A4 mRNA			[37]
Regulation Mechanism				Transcription Factor Info
Tetraethylammonium	13 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Atropine inhibits the reaction SLC22A4 protein results in increased uptake of Tetraethylammonium			[31]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Carvedilol inhibits the reaction SLC22A4 protein results in increased uptake of Tetraethylammonium			[31]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Diltiazem inhibits the reaction SLC22A4 protein results in increased uptake of Tetraethylammonium			[31]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Flecainide inhibits the reaction SLC22A4 protein results in increased uptake of Tetraethylammonium			[31]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Ipratropium inhibits the reaction SLC22A4 protein results in increased uptake of Tetraethylammonium			[31]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Lidocaine inhibits the reaction SLC22A4 protein results in increased uptake of Tetraethylammonium			[31]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	Nifedipine inhibits the reaction SLC22A4 protein results in increased uptake of Tetraethylammonium			[31]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	Propafenone inhibits the reaction SLC22A4 protein results in increased uptake of Tetraethylammonium			[31]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	Propranolol inhibits the reaction SLC22A4 protein results in increased uptake of Tetraethylammonium			[31]
Regulation Mechanism				Transcription Factor Info
DT Modulation10	SLC22A4 protein results in increased transport of Tetraethylammonium			[19]
Regulation Mechanism				Transcription Factor Info
DT Modulation11	SLC22A4 protein results in increased uptake of Tetraethylammonium			[44]
Regulation Mechanism				Transcription Factor Info
DT Modulation12	Spironolactone inhibits the reaction SLC22A4 protein results in increased uptake of Tetraethylammonium			[31]
Regulation Mechanism				Transcription Factor Info
DT Modulation13	Verapamil inhibits the reaction SLC22A4 protein results in increased uptake of Tetraethylammonium			[31]
Regulation Mechanism				Transcription Factor Info
tetrahydropalmatine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	tetrahydropalmatine inhibits the reaction SLC22A4 protein results in increased import of Oxaliplatin			[39]
Regulation Mechanism				Transcription Factor Info
Thiram	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Thiram results in decreased expression of SLC22A4 mRNA			[34]
Regulation Mechanism				Transcription Factor Info
trans-10,cis-12-conjugated linoleic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	trans-10,cis-12-conjugated linoleic acid results in increased expression of SLC22A4 mRNA			[45]
Regulation Mechanism				Transcription Factor Info
triphenyl phosphate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	triphenyl phosphate affects the expression of SLC22A4 mRNA			[35]
Regulation Mechanism				Transcription Factor Info
Approved Drug
Pyrilamide	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Pyrilamide inhibits the transportation of Ergothioneine by SLC22A4 (Ki = 182 microM)			[1]
Affected Drug/Substrate	Ergothioneine	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OCTN1
DT Modulation2	Pyrilamide inhibits the transportation of Tetraethylammonium by SLC22A4			[2]
Affected Drug/Substrate	Tetraethylammonium	Modulation Type	Inhibition
Cell System	Oocytes-OCTN1
Quinine	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Quinine inhibits the transportation of Tetraethylammonium by SLC22A4 (IC50 < 1000 microM)			[2]
Affected Drug/Substrate	Tetraethylammonium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OCTN1
DT Modulation2	Quinine inhibits the transportation of Ergothioneine by SLC22A4			[3]
Affected Drug/Substrate	Ergothioneine	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OCTN1
Methimazole	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Methimazole inhibits the transportation of Ergothioneine by SLC22A4 (Ki = 7520 microM)			[1]
Affected Drug/Substrate	Ergothioneine	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OCTN1
Verapamil	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Verapamil inhibits the transportation of Ergothioneine by SLC22A4 (Ki = 10.8 microM)			[1]
Affected Drug/Substrate	Ergothioneine	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OCTN1
Procainamide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Procainamide inhibits the transportation of Tetraethylammonium by SLC22A4 (IC50 < 1000 microM)			[2]
Affected Drug/Substrate	Tetraethylammonium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OCTN1
Linagliptin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Linagliptin inhibits the transportation of Ergothioneine by SLC22A4			[3]
Affected Drug/Substrate	Ergothioneine	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OCTN1
L-carnitine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	L-carnitine inhibits the transportation of Tetraethylammonium by SLC22A4			[2]
Affected Drug/Substrate	Tetraethylammonium	Modulation Type	Inhibition
Cell System	Oocytes-OCTN1
Nicotine polacrilex	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Nicotine inhibits the transportation of Tetraethylammonium by SLC22A4			[2]
Affected Drug/Substrate	Tetraethylammonium	Modulation Type	Inhibition
Cell System	Oocytes-OCTN1
Ofloxacin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ofloxacin inhibits the transportation of Tetraethylammonium by SLC22A4			[2]
Affected Drug/Substrate	Tetraethylammonium	Modulation Type	Inhibition
Cell System	Oocytes-OCTN1
Troglitazone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Troglitazone increases the expression of SLC22A4			[4]
Cyclosporine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cyclosporine increases the expression of SLC22A4			[5]
Zidovudine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Zidovudine increases the expression of SLC22A4			[6]
Zoledronic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Zoledronic Acid increases the expression of SLC22A4			[7]
Acetaminophen	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Acetaminophen inhibits the expression of SLC22A4			[8]
DT Modulation2	Acetaminophen results in increased expression of SLC22A4 mRNA			[28]
Regulation Mechanism				Transcription Factor Info
Decitabine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Decitabine increases the expression of SLC22A4			[9]
Leflunomide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Leflunomide inhibits the expression of SLC22A4			[10]
Doxorubicin	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Doxorubicin inhibits the expression of SLC22A4			[11]
Estradiol	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Estradiol increases the expression of SLC22A4			[12]
Valproic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Valproic Acid increases the expression of SLC22A4			[13]
Tretinoin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tretinoin increases the expression of SLC22A4			[14]
Cimetidine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cimetidine inhibits the activity of SLC22A4			[15]
Metformin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Metformin inhibits the reaction SLC22A4 protein results in increased abundance of Doxorubicin			[36]
Regulation Mechanism				Transcription Factor Info
Drug in Phase 2 Trial
Bisphenol A	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Bisphenol A increases the expression of SLC22A4			[23]
Discontinued Drug
Thioperamide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Thioperamide inhibits the transportation of Ergothioneine by SLC22A4 (Ki = 254 microM)			[1]
Affected Drug/Substrate	Ergothioneine	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OCTN1
Natural Product
Particulate Matter	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Particulate Matter increases the expression of SLC22A4			[22]
Tobacco Smoke Pollution	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tobacco Smoke Pollution inhibits the expression of SLC22A4			[26]
Environmental toxicant
Polychlorinated dibenzodioxin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Polychlorinated dibenzodioxin increases the expression of SLC22A4			[24]
Mercury	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Acetylcysteine inhibits the reaction Mercury results in decreased activity of SLC22A4 protein			[19]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Cysteine inhibits the reaction Mercury results in decreased activity of SLC22A4 protein			[19]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Dithioerythritol inhibits the reaction Mercury results in decreased activity of SLC22A4 protein			[19]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Mercury binds to and results in decreased activity of SLC22A4 protein			[19]
Regulation Mechanism				Transcription Factor Info
Mycotoxins
Aflatoxin B1	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Aflatoxin B1 increases the expression of SLC22A4			[17]
DT Modulation2	Aflatoxin B1 affects the expression of SLC22A4 protein			[5]
Regulation Mechanism				Transcription Factor Info
Acute Toxic Substance
Cycloheximide	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cycloheximide increases the expression of SLC22A4			[16]
Formaldehyde	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Formaldehyde increases the expression of SLC22A4			[18]
Cadmium	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cadmium inhibits the activity of SLC22A4			[19]
Thimerosal	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Thimerosal inhibits the activity of SLC22A4			[19]
Carcinogen
DT Modulation1	Cadmium results in decreased activity of SLC22A4 protein			[19]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Dithioerythritol inhibits the reaction Cadmium results in decreased activity of SLC22A4 protein			[19]
Regulation Mechanism				Transcription Factor Info
Benzo(a)pyrene	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Benzo(a)pyrene increases the expression of SLC22A4			[25]
Health and Environmental Toxicant
Perfluorooctane sulfonic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Perfluorooctane sulfonic acid increases the expression of SLC22A4			[20]
tris(1,3-dichloro-2-propyl)phosphate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	tris(1,3-dichloro-2-propyl)phosphate increases the expression of SLC22A4			[21]

References
1	Probing the substrate specificity of the ergothioneine transporter with methimazole, hercynine, and organic cations. Biochem Pharmacol. 2007 Jul 15;74(2):309-16.
2	Novel membrane transporter OCTN1 mediates multispecific, bidirectional, and pH-dependent transport of organic cations. J Pharmacol Exp Ther. 1999 May;289(2):768-73.
3	Evaluation and prediction of potential drug-drug interactions of linagliptin using in vitro cell culture methods. Drug Metab Dispos. 2013 Jan;41(1):149-58.
4	Effects of ciglitazone and troglitazone on the proliferation of human stomach cancer cells. World J Gastroenterol. 2009 Jan 21;15(3):310-20.
5	Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
6	Differential gene expression in human hepatocyte cell lines exposed to the antiretroviral agent zidovudine. Arch Toxicol. 2014 Mar;88(3):609-23.
7	Interleukin-19 as a translational indicator of renal injury. Arch Toxicol. 2015 Jan;89(1):101-6.
8	Blood transcript immune signatures distinguish a subset of people with elevated serum ALT from others given acetaminophen. Clin Pharmacol Ther. 2016 Apr;99(4):432-41.
9	Multiple drug transporters mediate the placental transport of sulpiride. Arch Toxicol. 2017 Dec;91(12):3873-3884.
10	Endoplasmic reticulum stress and MAPK signaling pathway activation underlie leflunomide-induced toxicity in HepG2 Cells. Toxicology. 2017 Dec 1;392:11-21.
11	Bringing in vitro analysis closer to in vivo: Studying doxorubicin toxicity and associated mechanisms in 3D human microtissues with PBPK-based dose modelling. Toxicol Lett. 2018 Sep 15;294:184-192.
12	17 beta-Estradiol Activates HSF1 via MAPK Signaling in ER alpha-Positive Breast Cancer Cells. Cancers (Basel). 2019 Oct 11;11(10):1533.
13	Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
14	Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423.
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16	Comparative analysis of AhR-mediated TCDD-elicited gene expression in human liver adult stem cells. Toxicol Sci. 2009 Nov;112(1):229-44.
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