Detail Information of Exogenous Modulation

General Information of Drug Transporter (DT)
DT ID	DTD0130 Transporter Info
Gene Name	SLC1A2
Transporter Name	Excitatory amino acid transporter 2
Gene ID	6506
UniProt ID	P43004

Exogenous factors (drugs, dietary constituents, etc.) Modulation of This DT (EGM)
Approved Drug
L-glutamic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	L-glutamic acid inhibits the transportation of D-Aspartate by SLC1A2			[1]
Affected Drug/Substrate	D-Aspartate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-EAAT2
Manganese chloride	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Manganese chloride inhibits the expression of SLC1A2			[3]
Regulation Mechanism	via enhancement of Transcriptional repressor protein YY1 (YY1)			Transcription Factor Info
Cell System	YY1-loxP homozygous mice astrocytes
Ampicillin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ampicillin increases the expression of SLC1A2			[4]
Hydrogen Peroxide	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Hydrogen Peroxide inhibits the expression of SLC1A2			[4]
Arsenic Trioxide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Arsenic Trioxide inhibits the expression of SLC1A2			[5]
Copper Sulfate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Copper Sulfate inhibits the expression of SLC1A2			[6]
Tretinoin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tretinoin inhibits the expression of SLC1A2			[7]
Thiamphenicol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Thiamphenicol increases the expression of SLC1A2			[8]
Cyclosporine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cyclosporine inhibits the expression of SLC1A2			[9]
Rifampin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Rifampin inhibits the expression of SLC1A2			[10]
Doxorubicin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Doxorubicin inhibits the expression of SLC1A2			[11]
Ivermectin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ivermectin inhibits the expression of SLC1A2			[12]
Estradiol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Estradiol inhibits the expression of SLC1A2			[13]
Valproic Acid	7 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Valproic Acid inhibits the expression of SLC1A2			[14]
Fingolimod	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Fingolimod induces the activity of SLC1A2			[15]
Etanercept	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Etanercept induces the activity of SLC1A2			[16]
Drug in Phase 3 Trial
Corticosterone	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Corticosterone increases the expression of SLC1A2			[4]
Vitamin A	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Vitamin A increases the expression of SLC1A2			[4]
Drug in Phase 2 Trial
Bisphenol A	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Bisphenol A inhibits the expression of SLC1A2			[24]
Drug in Phase 1 Trial
Quercetin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Quercetin inhibits the expression of SLC1A2			[13]
Trichostatin A	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Trichostatin A inhibits the expression of SLC1A2			[19]
Drug in Preclinical Test
(+)-JQ1	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	(+)-JQ1 inhibits the expression of SLC1A2			[22]
Investigative Drug
2S,4R-4-Methylglutamate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	2S,4R-4-Methylglutamate inhibits the activity of SLC1A2			[2]
Cell System	Human embryonic kidney 293 cells (HEK293)-EAAT2
Phenylmercuric Acetate	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Phenylmercuric Acetate inhibits the expression of SLC1A2			[21]
Natural Product
Cinnamic aldehyde	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cinnamic aldehyde increases the expression of SLC1A2			[17]
Deguelin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Deguelin inhibits the expression of SLC1A2			[25]
Environmental toxicant
Polychlorinated dibenzodioxin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Polychlorinated dibenzodioxin inhibits the expression of SLC1A2			[27]
Mycotoxins
Aflatoxin B1	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Aflatoxin B1 increases the expression of SLC1A2			[18]
DT Modulation2	Aflatoxin B1 results in decreased methylation of SLC1A2 gene			[31]
Regulation Mechanism				Transcription Factor Info
Acute Toxic Substance
Antimycin A	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Antimycin A inhibits the expression of SLC1A2			[25]
Carcinogen
Benzo(a)pyrene	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Benzo(a)pyrene inhibits the expression of SLC1A2			[27]
Cadmium	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cadmium Chloride results in increased abundance of Cadmium which results in increased expression of SLC1A2 mRNA			[35]
Regulation Mechanism				Transcription Factor Info
Fungicide
Azoxystrobin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Azoxystrobin inhibits the expression of SLC1A2			[25]
Health and Environmental Toxicant
Butyraldehyde	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Butyraldehyde increases the expression of SLC1A2			[20]
Diethylhexyl Phthalate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Diethylhexyl Phthalate inhibits the expression of SLC1A2			[23]
Perfluorooctane sulfonic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Perfluorooctane sulfonic acid increases the expression of SLC1A2			[26]
Chemical Compound
DT Modulation1	Corticosterone inhibits the reaction Hydrogen Peroxide results in decreased expression of SLC1A2 protein			[4]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Tretinoin results in increased expression of SLC1A2 mRNA			[48]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Valproic Acid inhibits the reaction manganese chloride results in decreased expression of SLC1A2 mRNA			[40]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Valproic Acid inhibits the reaction manganese chloride results in decreased expression of SLC1A2 protein			[40]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Valproic Acid promotes the reaction H4C16 protein modified form binds to SLC1A2 promoter			[49]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Valproic Acid results in decreased methylation of SLC1A2 gene			[51]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Valproic Acid results in increased expression of SLC1A2 mRNA			[49]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Valproic Acid results in increased expression of SLC1A2 protein			[40]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Corticosterone inhibits the reaction Hydrogen Peroxide results in decreased expression of SLC1A2 protein			[4]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Vitamin A promotes the reaction Corticosterone results in increased expression of SLC1A2 protein			[4]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Vitamin A promotes the reaction Corticosterone results in increased expression of SLC1A2 protein			[4]
Regulation Mechanism				Transcription Factor Info
Pentanal	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Pentanal increases the expression of SLC1A2			[20]
DT Modulation1	NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased expression of SLC1A2 mRNA			[29]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Benzo(a)pyrene affects the methylation of SLC1A2 3' UTR			[33]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Benzo(a)pyrene results in increased methylation of SLC1A2 promoter			[33]
Regulation Mechanism				Transcription Factor Info
2,3-dimethoxy-1,4-naphthoquinone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	2,3-dimethoxy-1,4-naphthoquinone results in decreased expression of SLC1A2 mRNA			[5]
Regulation Mechanism				Transcription Factor Info
2-palmitoylglycerol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	2-palmitoylglycerol results in increased expression of SLC1A2 mRNA			[28]
Regulation Mechanism				Transcription Factor Info
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased expression of SLC1A2 mRNA			[29]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased expression of SLC1A2 mRNA			[29]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased expression of SLC1A2 mRNA			[29]
Regulation Mechanism				Transcription Factor Info
4-chloro-N-((4-(1,1-dimethylethyl)phenyl)methyl)-3-ethyl-1-methyl-1H-pyrazole-5-carboxamide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	4-chloro-N-((4-(1,1-dimethylethyl)phenyl)methyl)-3-ethyl-1-methyl-1H-pyrazole-5-carboxamide results in decreased expression of SLC1A2 mRNA			[25]
Regulation Mechanism				Transcription Factor Info
Acetylcysteine	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Acetylcysteine inhibits the reaction manganese chloride results in increased abundance of Manganese which results in decreased expression of SLC1A2 mRNA			[30]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Acetylcysteine inhibits the reaction manganese chloride results in increased abundance of Manganese which results in decreased expression of SLC1A2 protein			[30]
Regulation Mechanism				Transcription Factor Info
Aldehydes	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Aldehydes results in increased expression of SLC1A2 mRNA			[32]
Regulation Mechanism				Transcription Factor Info
alpha-Tocopherol	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	alpha-Tocopherol inhibits the reaction manganese chloride results in increased abundance of Manganese which results in decreased expression of SLC1A2 mRNA			[30]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	alpha-Tocopherol inhibits the reaction manganese chloride results in increased abundance of Manganese which results in decreased expression of SLC1A2 protein			[30]
Regulation Mechanism				Transcription Factor Info
azoxystrobin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	azoxystrobin results in decreased expression of SLC1A2 mRNA			[25]
Regulation Mechanism				Transcription Factor Info
bisphenol A	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	bisphenol A affects the methylation of SLC1A2 gene			[34]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	bisphenol A co-treated with Fulvestrant results in increased methylation of SLC1A2 gene			[34]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	bisphenol A results in decreased expression of SLC1A2 protein			[24]
Regulation Mechanism				Transcription Factor Info
butyraldehyde	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	butyraldehyde results in increased expression of SLC1A2 mRNA			[20]
Regulation Mechanism				Transcription Factor Info
Cadmium Chloride	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cadmium Chloride results in increased abundance of Cadmium which results in increased expression of SLC1A2 mRNA			[35]
Regulation Mechanism				Transcription Factor Info
CGP 52608	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	CGP 52608 promotes the reaction RORA protein binds to SLC1A2 gene			[36]
Regulation Mechanism				Transcription Factor Info
cinnamaldehyde	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	cinnamaldehyde results in increased expression of SLC1A2 mRNA			[17]
Regulation Mechanism				Transcription Factor Info
Cisplatin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLC1A2 gene mutant form results in decreased susceptibility to Cisplatin			[37]
Regulation Mechanism				Transcription Factor Info
Cobalt	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	tungsten carbide co-treated with Cobalt results in decreased expression of SLC1A2 mRNA			[38]
Regulation Mechanism				Transcription Factor Info
deguelin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	deguelin results in decreased expression of SLC1A2 mRNA			[25]
Regulation Mechanism				Transcription Factor Info
dorsomorphin	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased expression of SLC1A2 mRNA			[29]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased expression of SLC1A2 mRNA			[29]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased expression of SLC1A2 mRNA			[29]
Regulation Mechanism				Transcription Factor Info
Fulvestrant	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	bisphenol A co-treated with Fulvestrant results in increased methylation of SLC1A2 gene			[34]
Regulation Mechanism				Transcription Factor Info
Hesperidin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Hesperidin inhibits the reaction manganese chloride results in increased abundance of Manganese promotes the reaction YY1 protein binds to SLC1A2 promoter			[39]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Hesperidin inhibits the reaction manganese chloride results in increased abundance of Manganese which results in decreased expression of SLC1A2 protein			[39]
Regulation Mechanism				Transcription Factor Info
Manganese	13 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Acetylcysteine inhibits the reaction manganese chloride results in increased abundance of Manganese which results in decreased expression of SLC1A2 mRNA			[30]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Acetylcysteine inhibits the reaction manganese chloride results in increased abundance of Manganese which results in decreased expression of SLC1A2 protein			[30]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	alpha-Tocopherol inhibits the reaction manganese chloride results in increased abundance of Manganese which results in decreased expression of SLC1A2 mRNA			[30]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	alpha-Tocopherol inhibits the reaction manganese chloride results in increased abundance of Manganese which results in decreased expression of SLC1A2 protein			[30]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Hesperidin inhibits the reaction manganese chloride results in increased abundance of Manganese promotes the reaction YY1 protein binds to SLC1A2 promoter			[39]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Hesperidin inhibits the reaction manganese chloride results in increased abundance of Manganese which results in decreased expression of SLC1A2 protein			[39]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	IkK-16 compound inhibits the reaction manganese chloride results in increased abundance of Manganese which results in decreased expression of SLC1A2 mRNA			[30]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	IkK-16 compound inhibits the reaction manganese chloride results in increased abundance of Manganese which results in decreased expression of SLC1A2 protein			[30]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	manganese chloride results in increased abundance of Manganese promotes the reaction YY1 protein binds to SLC1A2 promoter			[39]
Regulation Mechanism				Transcription Factor Info
DT Modulation10	manganese chloride results in increased abundance of Manganese which results in decreased expression of SLC1A2 mRNA			[30]
Regulation Mechanism				Transcription Factor Info
DT Modulation11	manganese chloride results in increased abundance of Manganese which results in decreased expression of SLC1A2 protein			[30]
Regulation Mechanism				Transcription Factor Info
DT Modulation12	silmitasertib inhibits the reaction manganese chloride results in increased abundance of Manganese promotes the reaction YY1 protein binds to SLC1A2 promoter			[39]
Regulation Mechanism				Transcription Factor Info
DT Modulation13	silmitasertib inhibits the reaction manganese chloride results in increased abundance of Manganese which results in decreased expression of SLC1A2 protein			[39]
Regulation Mechanism				Transcription Factor Info
manganese chloride	17 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Acetylcysteine inhibits the reaction manganese chloride results in increased abundance of Manganese which results in decreased expression of SLC1A2 mRNA			[30]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Acetylcysteine inhibits the reaction manganese chloride results in increased abundance of Manganese which results in decreased expression of SLC1A2 protein			[30]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	alpha-Tocopherol inhibits the reaction manganese chloride results in increased abundance of Manganese which results in decreased expression of SLC1A2 mRNA			[30]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	alpha-Tocopherol inhibits the reaction manganese chloride results in increased abundance of Manganese which results in decreased expression of SLC1A2 protein			[30]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Hesperidin inhibits the reaction manganese chloride results in increased abundance of Manganese promotes the reaction YY1 protein binds to SLC1A2 promoter			[39]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Hesperidin inhibits the reaction manganese chloride results in increased abundance of Manganese which results in decreased expression of SLC1A2 protein			[39]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	IkK-16 compound inhibits the reaction manganese chloride results in increased abundance of Manganese which results in decreased expression of SLC1A2 mRNA			[30]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	IkK-16 compound inhibits the reaction manganese chloride results in increased abundance of Manganese which results in decreased expression of SLC1A2 protein			[30]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	manganese chloride results in decreased expression of SLC1A2 mRNA			[40]
Regulation Mechanism				Transcription Factor Info
DT Modulation10	manganese chloride results in decreased expression of SLC1A2 protein			[40]
Regulation Mechanism				Transcription Factor Info
DT Modulation11	manganese chloride results in increased abundance of Manganese promotes the reaction YY1 protein binds to SLC1A2 promoter			[39]
Regulation Mechanism				Transcription Factor Info
DT Modulation12	manganese chloride results in increased abundance of Manganese which results in decreased expression of SLC1A2 mRNA			[30]
Regulation Mechanism				Transcription Factor Info
DT Modulation13	manganese chloride results in increased abundance of Manganese which results in decreased expression of SLC1A2 protein			[30]
Regulation Mechanism				Transcription Factor Info
DT Modulation14	silmitasertib inhibits the reaction manganese chloride results in increased abundance of Manganese promotes the reaction YY1 protein binds to SLC1A2 promoter			[39]
Regulation Mechanism				Transcription Factor Info
DT Modulation15	silmitasertib inhibits the reaction manganese chloride results in increased abundance of Manganese which results in decreased expression of SLC1A2 protein			[39]
Regulation Mechanism				Transcription Factor Info
DT Modulation16	Valproic Acid inhibits the reaction manganese chloride results in decreased expression of SLC1A2 mRNA			[40]
Regulation Mechanism				Transcription Factor Info
DT Modulation17	Valproic Acid inhibits the reaction manganese chloride results in decreased expression of SLC1A2 protein			[40]
Regulation Mechanism				Transcription Factor Info
mercuric bromide	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	mercuric bromide results in decreased expression of SLC1A2 mRNA			[21]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased expression of SLC1A2 mRNA			[29]
Regulation Mechanism				Transcription Factor Info
methylmercuric chloride	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	methylmercuric chloride results in increased expression of SLC1A2 mRNA			[41]
Regulation Mechanism				Transcription Factor Info
Okadaic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Okadaic Acid results in decreased expression of SLC1A2 mRNA			[42]
Regulation Mechanism				Transcription Factor Info
p-Chloromercuribenzoic Acid	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased expression of SLC1A2 mRNA			[29]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	p-Chloromercuribenzoic Acid results in decreased expression of SLC1A2 mRNA			[21]
Regulation Mechanism				Transcription Factor Info
Penicillins	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Penicillins results in increased expression of SLC1A2 protein			[4]
Regulation Mechanism				Transcription Factor Info
pentanal	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	pentanal results in increased expression of SLC1A2 mRNA			[20]
Regulation Mechanism				Transcription Factor Info
perfluorodecanesulfonic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	perfluorodecanesulfonic acid results in increased expression of SLC1A2 mRNA			[26]
Regulation Mechanism				Transcription Factor Info
perfluorooctane sulfonic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	perfluorooctane sulfonic acid results in increased expression of SLC1A2 mRNA			[26]
Regulation Mechanism				Transcription Factor Info
perfluorooctanoic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	perfluorooctanoic acid results in increased expression of SLC1A2 mRNA			[26]
Regulation Mechanism				Transcription Factor Info
picoxystrobin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	picoxystrobin results in decreased expression of SLC1A2 mRNA			[25]
Regulation Mechanism				Transcription Factor Info
propionaldehyde	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	propionaldehyde results in increased expression of SLC1A2 mRNA			[20]
Regulation Mechanism				Transcription Factor Info
pyrachlostrobin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	pyrachlostrobin results in decreased expression of SLC1A2 mRNA			[25]
Regulation Mechanism				Transcription Factor Info
pyrimidifen	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	pyrimidifen results in decreased expression of SLC1A2 mRNA			[25]
Regulation Mechanism				Transcription Factor Info
S-(1,2-dichlorovinyl)cysteine	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	S-(1,2-dichlorovinyl)cysteine affects the susceptibility to Lipopolysaccharides which results in increased expression of SLC1A2 mRNA			[43]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	S-(1,2-dichlorovinyl)cysteine co-treated with Lipopolysaccharides results in increased expression of SLC1A2 mRNA			[43]
Regulation Mechanism				Transcription Factor Info
silmitasertib	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	silmitasertib inhibits the reaction manganese chloride results in increased abundance of Manganese promotes the reaction YY1 protein binds to SLC1A2 promoter			[39]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	silmitasertib inhibits the reaction manganese chloride results in increased abundance of Manganese which results in decreased expression of SLC1A2 protein			[39]
Regulation Mechanism				Transcription Factor Info
Tetrachlorodibenzodioxin	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tetrachlorodibenzodioxin affects the expression of SLC1A2 mRNA			[44]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Tetrachlorodibenzodioxin results in decreased expression of SLC1A2 mRNA			[45]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Tetrachlorodibenzodioxin results in increased expression of SLC1A2 mRNA			[46]
Regulation Mechanism				Transcription Factor Info
thifluzamide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	thifluzamide results in decreased expression of SLC1A2 mRNA			[25]
Regulation Mechanism				Transcription Factor Info
TL8-506	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	TL8-506 co-treated with IFNG protein results in increased expression of SLC1A2 mRNA			[47]
Regulation Mechanism				Transcription Factor Info
trichostatin A	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	trichostatin A results in decreased expression of SLC1A2 mRNA			[19]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	trichostatin A results in increased expression of SLC1A2 mRNA			[49]
Regulation Mechanism				Transcription Factor Info
tris(2-butoxyethyl) phosphate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	tris(2-butoxyethyl) phosphate affects the expression of SLC1A2 mRNA			[50]
Regulation Mechanism				Transcription Factor Info
tungsten carbide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	tungsten carbide co-treated with Cobalt results in decreased expression of SLC1A2 mRNA			[38]
Regulation Mechanism				Transcription Factor Info

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