Detail Information of Exogenous Modulation

General Information of Drug Transporter (DT)
DT ID	DTD0129 Transporter Info
Gene Name	SLC1A1
Transporter Name	Excitatory amino acid transporter 3
Gene ID	6505
UniProt ID	P43005

Exogenous factors (drugs, dietary constituents, etc.) Modulation of This DT (EGM)
Chemical Compound
DT Modulation1	Estradiol co-treated with Progesterone results in decreased expression of SLC1A1 mRNA			[43]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Estradiol co-treated with Progesterone results in decreased expression of SLC1A1 mRNA			[43]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Estradiol co-treated with Tetrachlorodibenzodioxin results in decreased expression of SLC1A1 mRNA			[44]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Estradiol co-treated with TGFB1 protein results in decreased expression of SLC1A1 mRNA			[45]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC1A1 mRNA			[24]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Valproic Acid affects the expression of SLC1A1 mRNA			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Benzo(a)pyrene affects the methylation of SLC1A1 intron			[35]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Benzo(a)pyrene results in decreased methylation of SLC1A1 exon			[38]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC1A1 mRNA			[24]
Regulation Mechanism				Transcription Factor Info
2-palmitoylglycerol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	2-palmitoylglycerol results in increased expression of SLC1A1 mRNA			[31]
Regulation Mechanism				Transcription Factor Info
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC1A1 mRNA			[24]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC1A1 mRNA			[24]
Regulation Mechanism				Transcription Factor Info
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SLC1A1 mRNA			[32]
Regulation Mechanism				Transcription Factor Info
abrine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	abrine results in decreased expression of SLC1A1 mRNA			[33]
Regulation Mechanism				Transcription Factor Info
afimoxifene	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	afimoxifene results in decreased expression of SLC1A1 mRNA			[20]
Regulation Mechanism				Transcription Factor Info
allyl sulfide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	allyl sulfide inhibits the reaction tobacco tar analog results in decreased expression of SLC1A1 mRNA			[36]
Regulation Mechanism				Transcription Factor Info
aristolochic acid I	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	aristolochic acid I results in decreased expression of SLC1A1 mRNA			[37]
Regulation Mechanism				Transcription Factor Info
benzo(e)pyrene	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	benzo(e)pyrene results in increased methylation of SLC1A1 intron			[35]
Regulation Mechanism				Transcription Factor Info
bisphenol A	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	bisphenol A co-treated with Fulvestrant results in increased methylation of SLC1A1 gene			[39]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	bisphenol A results in increased expression of SLC1A1 mRNA			[28]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	bisphenol A results in increased methylation of SLC1A1 gene			[39]
Regulation Mechanism				Transcription Factor Info
Cisplatin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cisplatin co-treated with Panobinostat affects the expression of SLC1A1 mRNA			[40]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	SLC1A1 mRNA affects the susceptibility to Cisplatin			[41]
Regulation Mechanism				Transcription Factor Info
cobaltous chloride	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	cobaltous chloride results in increased expression of SLC1A1 mRNA			[42]
Regulation Mechanism				Transcription Factor Info
diallyl disulfide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	diallyl disulfide inhibits the reaction tobacco tar analog results in decreased expression of SLC1A1 mRNA			[36]
Regulation Mechanism				Transcription Factor Info
dorsomorphin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC1A1 mRNA			[24]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC1A1 mRNA			[24]
Regulation Mechanism				Transcription Factor Info
entinostat	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	entinostat results in increased expression of SLC1A1 mRNA			[24]
Regulation Mechanism				Transcription Factor Info
Fonofos	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Fonofos results in increased methylation of SLC1A1 promoter			[46]
Regulation Mechanism				Transcription Factor Info
Fulvestrant	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	bisphenol A co-treated with Fulvestrant results in increased methylation of SLC1A1 gene			[39]
Regulation Mechanism				Transcription Factor Info
Methapyrilene	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Methapyrilene results in increased methylation of SLC1A1 intron			[35]
Regulation Mechanism				Transcription Factor Info
methylmercuric chloride	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	methylmercuric chloride results in decreased expression of SLC1A1 mRNA			[47]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	methylmercuric chloride results in increased expression of SLC1A1 mRNA			[15]
Regulation Mechanism				Transcription Factor Info
Mitomycin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLC1A1 protein affects the susceptibility to Mitomycin			[48]
Regulation Mechanism				Transcription Factor Info
Okadaic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Okadaic Acid results in decreased expression of SLC1A1 mRNA			[49]
Regulation Mechanism				Transcription Factor Info
Panobinostat	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cisplatin co-treated with Panobinostat affects the expression of SLC1A1 mRNA			[40]
Regulation Mechanism				Transcription Factor Info
Parathion	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Parathion results in increased methylation of SLC1A1 promoter			[46]
Regulation Mechanism				Transcription Factor Info
potassium chromate(VI)	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	potassium chromate(VI) results in increased expression of SLC1A1 mRNA			[51]
Regulation Mechanism				Transcription Factor Info
Selenium	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Selenium results in decreased expression of SLC1A1 mRNA			[19]
Regulation Mechanism				Transcription Factor Info
Silicon Dioxide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Silicon Dioxide analog results in decreased expression of SLC1A1 mRNA			[52]
Regulation Mechanism				Transcription Factor Info
terbufos	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	terbufos results in increased methylation of SLC1A1 promoter			[46]
Regulation Mechanism				Transcription Factor Info
tert-Butylhydroperoxide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	tert-Butylhydroperoxide results in decreased expression of SLC1A1 mRNA			[53]
Regulation Mechanism				Transcription Factor Info
Tetrachlorodibenzodioxin	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Estradiol co-treated with Tetrachlorodibenzodioxin results in decreased expression of SLC1A1 mRNA			[44]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Tetrachlorodibenzodioxin results in decreased expression of SLC1A1 mRNA			[20]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Tetrachlorodibenzodioxin results in increased expression of SLC1A1 mRNA			[44]
Regulation Mechanism				Transcription Factor Info
trichostatin A	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	trichostatin A results in increased expression of SLC1A1 mRNA			[54]
Regulation Mechanism				Transcription Factor Info
Vanadium	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Vanadium results in decreased expression of SLC1A1 mRNA			[18]
Regulation Mechanism				Transcription Factor Info
Vitamin K 3	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Vitamin K 3 affects the expression of SLC1A1 mRNA			[5]
Regulation Mechanism				Transcription Factor Info
Nanoparticle
perfluoro-n-nonanoic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	perfluoro-n-nonanoic acid results in decreased expression of SLC1A1 mRNA			[50]
Regulation Mechanism				Transcription Factor Info
Approved Drug
L-glutamic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	L-glutamic acid inhibits the transportation of D-Aspartate by SLC1A1			[1]
Affected Drug/Substrate	D-Aspartate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-EAAT3
Calcitriol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Calcitriol increases the expression of SLC1A1			[3]
Vorinostat	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Vorinostat increases the expression of SLC1A1			[4]
Menadione	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Menadione affects the expression of SLC1A1			[5]
Progesterone	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Progesterone increases the expression of SLC1A1			[6]
Tretinoin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tretinoin inhibits the expression of SLC1A1			[7]
Zidovudine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Zidovudine increases the expression of SLC1A1			[8]
Carbamazepine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Carbamazepine affects the expression of SLC1A1			[9]
Doxorubicin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Doxorubicin affects the expression of SLC1A1			[10]
Sunitinib	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sunitinib inhibits the expression of SLC1A1			[12]
Ivermectin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ivermectin inhibits the expression of SLC1A1			[13]
Estradiol	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Estradiol increases the expression of SLC1A1			[14]
Valproic Acid	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Valproic Acid increases the expression of SLC1A1			[15]
Cyclosporine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cyclosporine inhibits the expression of SLC1A1			[16]
Desflurane	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Desflurane induces the activity of SLC1A1			[17]
Drug Marketed but not Approved by US FDA
Rotenone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Rotenone inhibits the expression of SLC1A1			[11]
Drug in Phase 3 Trial
Afimoxifene	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Afimoxifene inhibits the expression of SLC1A1			[20]
Drug in Phase 2 Trial
MS-275	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	MS-275 increases the expression of SLC1A1			[24]
Bisphenol A	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Bisphenol A increases the expression of SLC1A1			[28]
Drug in Phase 1 Trial
Trichostatin A	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Trichostatin A increases the expression of SLC1A1			[30]
Investigative Drug
2S,4R-4-Methylglutamate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	2S,4R-4-Methylglutamate inhibits the activity of SLC1A1			[2]
Cell System	Human embryonic kidney 293 cells (HEK293)-EAAT3
Phenylmercuric Acetate	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Phenylmercuric Acetate increases the expression of SLC1A1			[23]
Patented Pharmaceutical Agent
GSK-J4	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	GSK-J4 increases the expression of SLC1A1			[26]
Natural Product
Coal Ash	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Coal Ash inhibits the expression of SLC1A1			[18]
Selenium nanoparticles	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Selenium nanoparticles inhibits the expression of SLC1A1			[19]
Tobacco Smoke Pollution	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tobacco Smoke Pollution increases the expression of SLC1A1			[29]
Biotoxin
Dinophysistoxin 1	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Dinophysistoxin 1 inhibits the expression of SLC1A1			[25]
dinophysistoxin 1	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	dinophysistoxin 1 results in decreased expression of SLC1A1 mRNA			[25]
Regulation Mechanism				Transcription Factor Info
Environmental toxicant
Polychlorinated dibenzodioxin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Polychlorinated dibenzodioxin inhibits the expression of SLC1A1			[20]
Mycotoxins
Aflatoxin B1	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Aflatoxin B1 inhibits the expression of SLC1A1			[21]
DT Modulation2	Aflatoxin B1 affects the expression of SLC1A1 protein			[34]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Aflatoxin B1 results in increased methylation of SLC1A1 intron			[35]
Regulation Mechanism				Transcription Factor Info
Carcinogen
Benzo(a)pyrene	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Benzo(a)pyrene increases the expression of SLC1A1			[22]
Health and Environmental Toxicant
Diethylhexyl Phthalate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Diethylhexyl Phthalate increases the expression of SLC1A1			[27]

References
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Detail Information of Exogenous Modulation

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