Detail Information of Exogenous Modulation

General Information of Drug Transporter (DT)
DT ID DTD0124 Transporter Info
Gene Name SLC18A3
Transporter Name Vesicular acetylcholine transporter
Gene ID
6572
UniProt ID
Q16572
Exogenous factors (drugs, dietary constituents, etc.) Modulation of This DT (EGM)

Chemical Compound

  Benzo(a)pyrene

            2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Benzo(a)pyrene affects the methylation of SLC18A3 promoter [8]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation2

 Benzo(a)pyrene results in increased methylation of SLC18A3 5' UTR [8]

Regulation Mechanism

 Transcription Factor Info

  CGP 52608

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 CGP 52608 promotes the reaction RORA protein binds to SLC18A3 gene [9]

Regulation Mechanism

 Transcription Factor Info

  potassium perchlorate

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 potassium perchlorate results in decreased expression of SLC18A3 mRNA [5]

Regulation Mechanism

 Transcription Factor Info

  Raloxifene Hydrochloride

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Raloxifene Hydrochloride co-treated with ESR2 protein results in decreased expression of SLC18A3 mRNA [10]

Regulation Mechanism

 Transcription Factor Info

  sodium arsenite

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 sodium arsenite results in decreased expression of SLC18A3 mRNA [11]

Regulation Mechanism

 Transcription Factor Info

  Tamoxifen

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Tamoxifen co-treated with ESR2 protein results in decreased expression of SLC18A3 mRNA [10]

Regulation Mechanism

 Transcription Factor Info

Approved Drug

  Valproic Acid

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Valproic Acid affects the expression of SLC18A3 [4]

  Potassium perchlorate

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Potassium perchlorate inhibits the expression of SLC18A3 [5]

  Testosterone

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Testosterone inhibits the expression of SLC18A3 [6]

Drug in Phase 3 Trial

  Triclosan

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Triclosan increases the expression of SLC18A3 [7]

Investigative Drug

  Vesamicol

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Vesamicol inhibits the activity of SLC18A3 [1], [2], [3]

Cell System

 Rat adrenal chromaffin cells (PC12)-VACHT
References
1 Synthesis and in vitro and in vivo evaluation of 18F-labeled positron emission tomography (PET) ligands for imaging the vesicular acetylcholine transporter. J Med Chem. 2009 Mar 12;52(5):1358-69.
2 Synthesis and in vitro biological evaluation of carbonyl group-containing analogues for 1 receptors. J Med Chem. 2011 Aug 11;54(15):5362-72.
3 Synthesis and evaluation of in vitro bioactivity for vesicular acetylcholine transporter inhibitors containing two carbonyl groups. Bioorg Med Chem. 2012 Jul 15;20(14):4422-9.
4 Gene Expression Regulation and Pathway Analysis After Valproic Acid and Carbamazepine Exposure in a Human Embryonic Stem Cell-Based Neurodevelopmental Toxicity Assay. Toxicol Sci. 2015 Aug;146(2):311-20.
5 Changes in trophoblasts gene expression in response to perchlorate exposition. Toxicol In Vitro. 2018 Aug;50:328-335.
6 The exosome-like vesicles derived from androgen exposed-prostate stromal cells promote epithelial cells proliferation and epithelial-mesenchymal transition. Toxicol Appl Pharmacol. 2021 Jan 15;411:115384.
7 Transcriptome and DNA Methylome Dynamics during Triclosan-Induced Cardiomyocyte Differentiation Toxicity. Stem Cells Int. 2018 Oct 29;2018:8608327.
8 Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017;8(1):1369-1391.
9 Identification of potential target genes of ROR-alpha in THP1 and HUVEC cell lines. Exp Cell Res. 2017;353(1):6-15.
10 Cell type- and estrogen receptor-subtype specific regulation of selective estrogen receptor modulator regulatory elements. Mol Cell Endocrinol. 2009;299(2):204-11.
11 A Comprehensive Transcriptomic Analysis of Arsenic-Induced Bladder Carcinogenesis. Cells. 2022;11(15).

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