Detail Information of Exogenous Modulation

General Information of Drug Transporter (DT)
DT ID DTD0123 Transporter Info
Gene Name SLC18A1
Transporter Name Vesicular amine transporter 1
Gene ID
6570
UniProt ID
P54219
Exogenous factors (drugs, dietary constituents, etc.) Modulation of This DT (EGM)

Chemical Compound

  DT Modulation1

 Reserpine inhibits the reaction SLC18A1 protein results in increased uptake of Serotonin [8]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation1

 Tetrabenazine inhibits the reaction SLC18A1 protein results in increased uptake of Serotonin [8]

Regulation Mechanism

 Transcription Factor Info

  1-Methyl-4-phenylpyridinium

            2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 1-Methyl-4-phenylpyridinium inhibits the reaction SLC18A1 protein results in increased uptake of Serotonin [8]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation2

 U 0126 affects the reaction 1-Methyl-4-phenylpyridinium affects the expression of SLC18A1 mRNA [9]

Regulation Mechanism

 Transcription Factor Info

  Benzo(a)pyrene

            2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Benzo(a)pyrene affects the methylation of SLC18A1 promoter [10]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation2

 Benzo(a)pyrene results in increased methylation of SLC18A1 5' UTR [10]

Regulation Mechanism

 Transcription Factor Info

  beta-methylcholine

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 beta-methylcholine affects the expression of SLC18A1 mRNA [11]

Regulation Mechanism

 Transcription Factor Info

  CGP 52608

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 CGP 52608 promotes the reaction RORA protein binds to SLC18A1 gene [12]

Regulation Mechanism

 Transcription Factor Info

  Dopamine

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Dopamine inhibits the reaction SLC18A1 protein results in increased uptake of Serotonin [8]

Regulation Mechanism

 Transcription Factor Info

  Histamine

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Histamine inhibits the reaction SLC18A1 protein results in increased uptake of Serotonin [8]

Regulation Mechanism

 Transcription Factor Info

  naphthol AS-E phosphate

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 naphthol AS-E phosphate results in decreased expression of SLC18A1 mRNA [13]

Regulation Mechanism

 Transcription Factor Info

  Norepinephrine

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Norepinephrine inhibits the reaction SLC18A1 protein results in increased uptake of Serotonin [8]

Regulation Mechanism

 Transcription Factor Info

  phenethylamine

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 phenethylamine inhibits the reaction SLC18A1 protein results in increased uptake of Serotonin [8]

Regulation Mechanism

 Transcription Factor Info

  propionaldehyde

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 propionaldehyde results in decreased expression of SLC18A1 mRNA [14]

Regulation Mechanism

 Transcription Factor Info

  Serotonin

            8 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 1-Methyl-4-phenylpyridinium inhibits the reaction SLC18A1 protein results in increased uptake of Serotonin [8]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation2

 Dopamine inhibits the reaction SLC18A1 protein results in increased uptake of Serotonin [8]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation3

 Histamine inhibits the reaction SLC18A1 protein results in increased uptake of Serotonin [8]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation4

 Norepinephrine inhibits the reaction SLC18A1 protein results in increased uptake of Serotonin [8]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation5

 phenethylamine inhibits the reaction SLC18A1 protein results in increased uptake of Serotonin [8]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation6

 Reserpine inhibits the reaction SLC18A1 protein results in increased uptake of Serotonin [8]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation7

 SLC18A1 protein results in increased uptake of Serotonin [8]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation8

 Tetrabenazine inhibits the reaction SLC18A1 protein results in increased uptake of Serotonin [8]

Regulation Mechanism

 Transcription Factor Info

  U 0126

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 U 0126 affects the reaction 1-Methyl-4-phenylpyridinium affects the expression of SLC18A1 mRNA [9]

Regulation Mechanism

 Transcription Factor Info

Natural Product

  Resveratrol

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Plant Extracts co-treated with Resveratrol results in decreased expression of SLC18A1 mRNA [15]

Regulation Mechanism

 Transcription Factor Info

Approved Drug

  Tretinoin

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Tretinoin increases the expression of SLC18A1 [1]

  Permethrin

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Permethrin increases the expression of SLC18A1 [2]

  Reserpine

            2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Reserpine inhibits the activity of SLC18A1 [3]

  Tetrabenazine

            2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Tetrabenazine inhibits the activity of SLC18A1 [4], [5]

Drug in Preclinical Test

  (+)-JQ1

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 (+)-JQ1 inhibits the expression of SLC18A1 [6]

Drug Withdrawn

  Fenfluramine

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Fenfluramine inhibits the activity of SLC18A1 [7]
References
1 Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423.
2 Exposure to Insecticides Modifies Gene Expression and DNA Methylation in Hematopoietic Tissues In Vitro. Int J Mol Sci. 2023 Mar 26;24(7):6259.
3 Amine precursor uptake and decarboxylation: significance for processing of the rat gastrin precursor. J Physiol. 1997 Jun 1;501 ( Pt 2):363-74.
4 Individual residues contribute to multiple differences in ligand recognition between vesicular monoamine transporters 1 and 2. J Biol Chem. 1997 Jun 27;272(26):16301-7.
5 Multiple residues contribute independently to differences in ligand recognition between vesicular monoamine transporters 1 and 2. J Biol Chem. 1998 Feb 13;273(7):3943-7.
6 Targeting MYCN in neuroblastoma by BET bromodomain inhibition. Cancer Discov. 2013 Mar;3(3):308-23.
7 Tubal sterility: Disturbances in haemostasis and cardiac arrest during the shirodkar manoeuvre (author's transl). Nouv Presse Med. 1978 Mar 11;7(10):827-30.
8 Functional identification and molecular cloning of a human brain vesicle monoamine transporter. J Neurochem. 1993;61(6):2314-7.
9 Dependence on electron transport chain function and intracellular signaling of genomic responses in SH-SY5Y cells to the mitochondrial neurotoxin MPP(+). Exp Neurol. 2003 May;181(1):25-38.
10 Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017;8(1):1369-1391.
11 Minimal peroxide exposure of neuronal cells induces multifaceted adaptive responses. PLoS One. 2010 Dec 17;5(12):e14352.
12 Identification of potential target genes of ROR-alpha in THP1 and HUVEC cell lines. Exp Cell Res. 2017;353(1):6-15.
13 Development of a pluripotent stem cell derived neuronal model to identify chemically induced pathway perturbations in relation to neurotoxicity: effects of CREB pathway inhibition. Toxicol Appl Pharmacol. 2014;280(2):378-88.
14 Integrated analysis of microRNA and mRNA expression profiles highlights aldehyde-induced inflammatory responses in cells relevant for lung toxicity. Toxicology. 2015 Aug 6;334:111-21.
15 One-year supplementation with a grape extract containing resveratrol modulates inflammatory-related microRNAs and cytokines expression in peripheral blood mononuclear cells of type 2 diabetes and hypertensive patients with coronary artery disease. Pharmacol Res. 2013;72:69-82.

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