Detail Information of Exogenous Modulation

General Information of Drug Transporter (DT)
DT ID	DTD0105 Transporter Info
Gene Name	SLC16A14
Transporter Name	Monocarboxylate transporter 14
Gene ID	151473
UniProt ID	Q7RTX9

Exogenous factors (drugs, dietary constituents, etc.) Modulation of This DT (EGM)
Chemical Compound
DT Modulation1	Testosterone co-treated with Calcitriol results in decreased expression of SLC16A14 mRNA		[1]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Testosterone co-treated with Calcitriol results in decreased expression of SLC16A14 mRNA		[1]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased expression of SLC16A14 mRNA		[15]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Estradiol co-treated with TGFB1 protein results in decreased expression of SLC16A14 mRNA		[34]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Valproic Acid affects the expression of SLC16A14 mRNA		[41]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Valproic Acid results in increased expression of SLC16A14 mRNA		[40]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Gasoline co-treated with Ethanol results in increased abundance of Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons which results in decreased expression of SLC16A14 mRNA		[25]
Regulation Mechanism			Transcription Factor Info
1-Butanol	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Gasoline co-treated with 1-Butanol results in increased abundance of Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons which results in decreased expression of SLC16A14 mRNA		[25]
Regulation Mechanism			Transcription Factor Info
1-Methyl-4-phenylpyridinium	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	1-Methyl-4-phenylpyridinium results in increased expression of SLC16A14 mRNA		[13]
Regulation Mechanism			Transcription Factor Info
2,5,2',5'-tetrachlorobiphenyl	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	2,5,2',5'-tetrachlorobiphenyl analog results in increased expression of SLC16A14 mRNA		[26]
Regulation Mechanism			Transcription Factor Info
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid results in increased expression of SLC16A14 mRNA		[14]
Regulation Mechanism			Transcription Factor Info
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	4 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	NOG protein co-treated with belinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased expression of SLC16A14 mRNA		[15]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased expression of SLC16A14 mRNA		[15]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased expression of SLC16A14 mRNA		[15]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased expression of SLC16A14 mRNA		[15]
Regulation Mechanism			Transcription Factor Info
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SLC16A14 mRNA		[27]
Regulation Mechanism			Transcription Factor Info
belinostat	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	belinostat results in decreased expression of SLC16A14 mRNA		[4]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	NOG protein co-treated with belinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased expression of SLC16A14 mRNA		[15]
Regulation Mechanism			Transcription Factor Info
bisphenol A	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	bisphenol A results in increased expression of SLC16A14 mRNA		[18]
Regulation Mechanism			Transcription Factor Info
CGP 52608	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	CGP 52608 promotes the reaction RORA protein binds to SLC16A14 gene		[31]
Regulation Mechanism			Transcription Factor Info
Copper	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	NSC 689534 binds to Copper which results in decreased expression of SLC16A14 mRNA		[32]
Regulation Mechanism			Transcription Factor Info
cupric chloride	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	cupric chloride results in decreased expression of SLC16A14 mRNA		[33]
Regulation Mechanism			Transcription Factor Info
Dichlorodiphenyl Dichloroethylene	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Dichlorodiphenyl Dichloroethylene results in increased expression of SLC16A14 mRNA		[33]
Regulation Mechanism			Transcription Factor Info
dorsomorphin	4 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	NOG protein co-treated with belinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased expression of SLC16A14 mRNA		[15]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased expression of SLC16A14 mRNA		[15]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased expression of SLC16A14 mRNA		[15]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased expression of SLC16A14 mRNA		[15]
Regulation Mechanism			Transcription Factor Info
entinostat	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	entinostat results in decreased expression of SLC16A14 mRNA		[4]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased expression of SLC16A14 mRNA		[15]
Regulation Mechanism			Transcription Factor Info
Gasoline	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Gasoline co-treated with 1-Butanol results in increased abundance of Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons which results in decreased expression of SLC16A14 mRNA		[25]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Gasoline co-treated with Ethanol results in increased abundance of Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons which results in decreased expression of SLC16A14 mRNA		[25]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	Gasoline results in increased abundance of Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons which results in decreased expression of SLC16A14 mRNA		[25]
Regulation Mechanism			Transcription Factor Info
ICG 001	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	ICG 001 results in increased expression of SLC16A14 mRNA		[14]
Regulation Mechanism			Transcription Factor Info
Manganese	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	manganese chloride results in increased abundance of Manganese which results in increased expression of SLC16A14 mRNA		[30]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	sodium arsenite results in increased abundance of Arsenic co-treated with manganese chloride results in increased abundance of Manganese results in increased expression of SLC16A14 mRNA		[30]
Regulation Mechanism			Transcription Factor Info
manganese chloride	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	manganese chloride results in increased abundance of Manganese which results in increased expression of SLC16A14 mRNA		[30]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	sodium arsenite results in increased abundance of Arsenic co-treated with manganese chloride results in increased abundance of Manganese results in increased expression of SLC16A14 mRNA		[30]
Regulation Mechanism			Transcription Factor Info
methylmercuric chloride	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	methylmercuric chloride results in increased expression of SLC16A14 mRNA		[12]
Regulation Mechanism			Transcription Factor Info
Methyl Methanesulfonate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Methyl Methanesulfonate results in decreased expression of SLC16A14 mRNA		[2]
Regulation Mechanism			Transcription Factor Info
Niclosamide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Niclosamide results in increased expression of SLC16A14 mRNA		[36]
Regulation Mechanism			Transcription Factor Info
NSC 689534	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	NSC 689534 binds to Copper which results in decreased expression of SLC16A14 mRNA		[32]
Regulation Mechanism			Transcription Factor Info
Ozone	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Air Pollutants results in increased abundance of Ozone which affects the expression of SLC16A14 mRNA		[37]
Regulation Mechanism			Transcription Factor Info
potassium chromate(VI)	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	potassium chromate(VI) results in decreased expression of SLC16A14 mRNA		[38]
Regulation Mechanism			Transcription Factor Info
S-(1,2-dichlorovinyl)cysteine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	S-(1,2-dichlorovinyl)cysteine affects the susceptibility to Lipopolysaccharides which results in increased expression of SLC16A14 mRNA		[39]
Regulation Mechanism			Transcription Factor Info
sodium arsenite	4 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	sodium arsenite results in decreased expression of SLC16A14 mRNA		[33]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	sodium arsenite results in increased abundance of Arsenic co-treated with manganese chloride results in increased abundance of Manganese results in increased expression of SLC16A14 mRNA		[30]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	sodium arsenite results in increased abundance of Arsenic which results in increased expression of SLC16A14 mRNA		[30]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	sodium arsenite results in increased expression of SLC16A14 mRNA		[23]
Regulation Mechanism			Transcription Factor Info
sulforaphane	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	sulforaphane results in increased expression of SLC16A14 mRNA		[22]
Regulation Mechanism			Transcription Factor Info
Tetrachlorodibenzodioxin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Tetrachlorodibenzodioxin results in decreased expression of SLC16A14 mRNA		[17]
Regulation Mechanism			Transcription Factor Info
Thiram	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Thiram results in decreased expression of SLC16A14 mRNA		[33]
Regulation Mechanism			Transcription Factor Info
trichostatin A	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased expression of SLC16A14 mRNA		[15]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	trichostatin A results in decreased expression of SLC16A14 mRNA		[40]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	trichostatin A results in increased expression of SLC16A14 mRNA		[40]
Regulation Mechanism			Transcription Factor Info
Mycotoxins
Aflatoxin B1	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Aflatoxin B1 results in increased methylation of SLC16A14 intron		[28]
Regulation Mechanism			Transcription Factor Info
Drug Withdrawn
Fenfluramine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Fenfluramine results in decreased expression of SLC16A14 mRNA		[35]
Regulation Mechanism			Transcription Factor Info
Approved Drug
Calcitriol	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Calcitriol inhibits the expression of SLC16A14		[1]
Testosterone	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Testosterone inhibits the expression of SLC16A14		[1]
Vincristine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Vincristine inhibits the expression of SLC16A14		[2]
Zoledronic Acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Zoledronic Acid inhibits the expression of SLC16A14		[3]
Belinostat	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Belinostat inhibits the expression of SLC16A14		[4]
Panobinostat	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Panobinostat inhibits the expression of SLC16A14		[4]
Cyclosporine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Cyclosporine inhibits the expression of SLC16A14		[5]
Leflunomide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Leflunomide increases the expression of SLC16A14		[6]
Sunitinib	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Sunitinib inhibits the expression of SLC16A14		[8]
Estradiol	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Estradiol increases the expression of SLC16A14		[9]
Temozolomide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Temozolomide inhibits the expression of SLC16A14		[10]
Tretinoin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Tretinoin inhibits the expression of SLC16A14		[11]
Valproic Acid	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Valproic Acid inhibits the expression of SLC16A14		[12]
Drug Marketed but not Approved by US FDA
Demecolcine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Demecolcine inhibits the expression of SLC16A14		[2]
Rotenone	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Rotenone increases the expression of SLC16A14		[7]
Drug in Phase 3 Trial
Sulforafan	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Sulforafan increases the expression of SLC16A14		[22]
Drug in Phase 2 Trial
MS-275	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	MS-275 inhibits the expression of SLC16A14		[4]
Bisphenol A	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Bisphenol A increases the expression of SLC16A14		[18]
Ethanol	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Ethanol increases the expression of SLC16A14		[20]
Drug in Phase 1 Trial
Sodium arsenite	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Sodium arsenite increases the expression of SLC16A14		[23]
Trichostatin A	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Trichostatin A inhibits the expression of SLC16A14		[4]
Drug in Preclinical Test
(+)-JQ1	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	(+)-JQ1 inhibits the expression of SLC16A14		[16]
Patented Pharmaceutical Agent
ICG-001	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	ICG-001 increases the expression of SLC16A14		[14]
Natural Product
Particulate Matter	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Particulate Matter increases the expression of SLC16A14		[19]
Tobacco Smoke Pollution	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Tobacco Smoke Pollution inhibits the expression of SLC16A14		[24]
Environmental toxicant
Polychlorinated dibenzodioxin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Polychlorinated dibenzodioxin inhibits the expression of SLC16A14		[17]
Acute Toxic Substance
Formaldehyde	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Formaldehyde inhibits the expression of SLC16A14		[2]
Thimerosal	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Thimerosal increases the expression of SLC16A14		[15]
Carcinogen
Ethyl Methanesulfonate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Ethyl Methanesulfonate inhibits the expression of SLC16A14		[2]
Arsenic	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Arsenic affects the methylation of SLC16A14 gene		[29]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	sodium arsenite results in increased abundance of Arsenic co-treated with manganese chloride results in increased abundance of Manganese results in increased expression of SLC16A14 mRNA		[30]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	sodium arsenite results in increased abundance of Arsenic which results in increased expression of SLC16A14 mRNA		[30]
Regulation Mechanism			Transcription Factor Info
Health and Environmental Toxicant
1-methyl-4-phenylpyridinium	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	1-methyl-4-phenylpyridinium increases the expression of SLC16A14		[13]
Diethylhexyl Phthalate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Diethylhexyl Phthalate inhibits the expression of SLC16A14		[21]

References
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