Detail Information of Exogenous Modulation

General Information of Drug Transporter (DT)
DT ID	DTD0100 Transporter Info
Gene Name	SLC16A1
Transporter Name	Monocarboxylate transporter 1
Gene ID	6566
UniProt ID	P53985

Exogenous factors (drugs, dietary constituents, etc.) Modulation of This DT (EGM)
Chemical Compound
DT Modulation1	motexafin gadolinium affects the reaction Zinc Acetate results in increased expression of SLC16A1 mRNA			[6]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Indomethacin inhibits the reaction SLC16A1 protein results in increased uptake of Butyrates			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Dronabinol inhibits the reaction SLC16A1 protein results in increased uptake of Butyrates			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Decitabine affects the methylation of SLC16A1 gene			[59]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Decitabine co-treated with trichostatin A results in increased expression of SLC16A1 mRNA			[12]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Cisplatin inhibits the reaction Piroxicam results in increased expression of SLC16A1 mRNA			[14]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Cyclosporine results in increased expression of SLC16A1 mRNA			[57]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC16A1 mRNA			[33]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	EGF protein promotes the reaction Estradiol results in increased expression of SLC16A1 mRNA			[60]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Estradiol co-treated with Tetrachlorodibenzodioxin results in decreased expression of SLC16A1 mRNA			[61]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC16A1 mRNA			[33]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Valproic Acid affects the expression of SLC16A1 mRNA			[77]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein affects the expression of SLC16A1 mRNA			[58]
Regulation Mechanism				Transcription Factor Info
2,4-Dinitrophenol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	2,4-Dinitrophenol inhibits the reaction SLC16A1 protein results in increased uptake of Lactic Acid			[41]
Regulation Mechanism				Transcription Factor Info
3-methyladenine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	3-methyladenine inhibits the reaction Cadmium Chloride results in increased abundance of Cadmium which results in increased expression of SLC16A1 protein			[42]
Regulation Mechanism				Transcription Factor Info
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	5 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	LDN 193189 co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with FGF2 protein results in decreased expression of SLC16A1 protein			[43]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC16A1 mRNA			[33]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC16A1 mRNA			[33]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC16A1 mRNA			[33]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC16A1 mRNA			[33]
Regulation Mechanism				Transcription Factor Info
4-Chloromercuribenzenesulfonate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	4-Chloromercuribenzenesulfonate inhibits the reaction SLC16A1 protein results in increased uptake of Lactic Acid			[41]
Regulation Mechanism				Transcription Factor Info
5-nitro-2-(3-phenylpropylamino)benzoic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	5-nitro-2-(3-phenylpropylamino)benzoic acid inhibits the reaction SLC16A1 protein results in increased uptake of Butyrates			[9]
Regulation Mechanism				Transcription Factor Info
Acetaldehyde	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Acetaldehyde inhibits the reaction SLC16A1 protein results in increased uptake of Butyrates			[9]
Regulation Mechanism				Transcription Factor Info
Acetates	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Acetates inhibits the reaction SLC16A1 protein results in increased uptake of Butyrates			[9]
Regulation Mechanism				Transcription Factor Info
alpha-ketobutyric acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	alpha-ketobutyric acid inhibits the reaction SLC16A1 protein results in increased uptake of Butyrates			[9]
Regulation Mechanism				Transcription Factor Info
AR C155858	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	AR C155858 binds to and results in increased stability of and results in decreased activity of SLC16A1 protein			[44]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	AR C155858 results in decreased activity of SLC16A1 protein			[45]
Regulation Mechanism				Transcription Factor Info
aristolochic acid I	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	aristolochic acid I results in decreased expression of SLC16A1 mRNA			[46]
Regulation Mechanism				Transcription Factor Info
AZD3965	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	AZD3965 binds to and results in increased stability of and results in decreased activity of SLC16A1 protein			[44]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	AZD3965 inhibits the reaction ATG4B protein results in increased expression of SLC16A1 protein			[42]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	AZD3965 inhibits the reaction Cadmium Chloride results in increased abundance of Cadmium which results in increased expression of SLC16A1 protein			[42]
Regulation Mechanism				Transcription Factor Info
Benzo(a)pyrene	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Benzo(a)pyrene affects the methylation of SLC16A1 promoter			[48]
Regulation Mechanism				Transcription Factor Info
Benzoic Acid	7 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Benzoic Acid inhibits the reaction SLC16A1 protein results in increased uptake of Lactic Acid			[41]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	morin inhibits the reaction SLC16A1 protein results in increased uptake of Benzoic Acid			[49]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	MYC protein results in increased expression of SLC16A1 protein which results in increased import of Benzoic Acid			[50]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	naringenin inhibits the reaction SLC16A1 protein results in increased uptake of Benzoic Acid			[49]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Quercetin inhibits the reaction SLC16A1 protein results in increased uptake of Benzoic Acid			[49]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Silybin inhibits the reaction SLC16A1 protein results in increased uptake of Benzoic Acid			[49]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	SLC16A1 protein results in increased uptake of Benzoic Acid			[49]
Regulation Mechanism				Transcription Factor Info
bisphenol A	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	bisphenol A results in decreased expression of SLC16A1 mRNA			[12]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	bisphenol A results in decreased expression of SLC16A1 protein			[51]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	bisphenol A results in decreased methylation of SLC16A1 gene			[52]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	bisphenol A results in increased expression of SLC16A1 protein			[35]
Regulation Mechanism				Transcription Factor Info
bisphenol B	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	bisphenol B results in increased expression of SLC16A1 protein			[35]
Regulation Mechanism				Transcription Factor Info
bisphenol S	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	bisphenol S results in increased expression of SLC16A1 protein			[35]
Regulation Mechanism				Transcription Factor Info
bromopyruvate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLC16A1 protein results in increased uptake of and results in increased susceptibility to bromopyruvate			[53]
Regulation Mechanism				Transcription Factor Info
Cadmium Chloride	5 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	3-methyladenine inhibits the reaction Cadmium Chloride results in increased abundance of Cadmium which results in increased expression of SLC16A1 protein			[42]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	AZD3965 inhibits the reaction Cadmium Chloride results in increased abundance of Cadmium which results in increased expression of SLC16A1 protein			[42]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Cadmium Chloride results in increased abundance of Cadmium which results in increased expression of SLC16A1 mRNA			[54]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Cadmium Chloride results in increased abundance of Cadmium which results in increased expression of SLC16A1 protein			[42]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Lactic Acid co-treated with Deoxyglucose promotes the reaction Cadmium Chloride results in increased abundance of Cadmium which results in increased expression of SLC16A1 protein			[42]
Regulation Mechanism				Transcription Factor Info
Cisplatin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cisplatin inhibits the reaction Piroxicam results in increased expression of SLC16A1 mRNA			[14]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Cisplatin results in decreased susceptibility to Cisplatin which results in increased expression of SLC16A1 mRNA			[56]
Regulation Mechanism				Transcription Factor Info
Cycloheximide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tetrachlorodibenzodioxin co-treated with Cycloheximide results in increased expression of SLC16A1 mRNA			[36]
Regulation Mechanism				Transcription Factor Info
daidzein	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein affects the expression of SLC16A1 mRNA			[58]
Regulation Mechanism				Transcription Factor Info
daidzin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein affects the expression of SLC16A1 mRNA			[58]
Regulation Mechanism				Transcription Factor Info
Deoxyglucose	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Lactic Acid co-treated with Deoxyglucose promotes the reaction Cadmium Chloride results in increased abundance of Cadmium which results in increased expression of SLC16A1 protein			[42]
Regulation Mechanism				Transcription Factor Info
Dithiothreitol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Dithiothreitol inhibits the reaction SLC16A1 protein results in increased uptake of Lactic Acid			[41]
Regulation Mechanism				Transcription Factor Info
dorsomorphin	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC16A1 mRNA			[33]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC16A1 mRNA			[33]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC16A1 mRNA			[33]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC16A1 mRNA			[33]
Regulation Mechanism				Transcription Factor Info
entinostat	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	entinostat results in increased expression of SLC16A1 mRNA			[17]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC16A1 mRNA			[33]
Regulation Mechanism				Transcription Factor Info
Ethylmaleimide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ethylmaleimide inhibits the reaction SLC16A1 protein results in increased uptake of Lactic Acid			[41]
Regulation Mechanism				Transcription Factor Info
fenofibric acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	fenofibric acid binds to PPARA protein which results in increased expression of SLC16A1 mRNA			[62]
Regulation Mechanism				Transcription Factor Info
formic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	formic acid binds to and results in increased stability of and affects the activity of SLC16A1 protein			[44]
Regulation Mechanism				Transcription Factor Info
FR900359	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	FR900359 affects the phosphorylation of SLC16A1 protein			[63]
Regulation Mechanism				Transcription Factor Info
Furaldehyde	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sodium Chloride co-treated with Furaldehyde results in decreased expression of and affects the localization of SLC16A1 protein			[64]
Regulation Mechanism				Transcription Factor Info
geldanamycin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	geldanamycin results in increased expression of SLC16A1 mRNA			[31]
Regulation Mechanism				Transcription Factor Info
genistin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein affects the expression of SLC16A1 mRNA			[58]
Regulation Mechanism				Transcription Factor Info
glycitein	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein affects the expression of SLC16A1 mRNA			[58]
Regulation Mechanism				Transcription Factor Info
glycitin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein affects the expression of SLC16A1 mRNA			[58]
Regulation Mechanism				Transcription Factor Info
Josamycin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLC16A1 protein affects the susceptibility to Josamycin			[65]
Regulation Mechanism				Transcription Factor Info
kaempferol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	kaempferol inhibits the reaction SLC16A1 protein results in increased uptake of Lactic Acid			[66]
Regulation Mechanism				Transcription Factor Info
Lactic Acid	16 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	2,4-Dinitrophenol inhibits the reaction SLC16A1 protein results in increased uptake of Lactic Acid			[41]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	4-Chloromercuribenzenesulfonate inhibits the reaction SLC16A1 protein results in increased uptake of Lactic Acid			[41]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Benzoic Acid inhibits the reaction SLC16A1 protein results in increased uptake of Lactic Acid			[41]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Dithiothreitol inhibits the reaction SLC16A1 protein results in increased uptake of Lactic Acid			[41]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Ethylmaleimide inhibits the reaction SLC16A1 protein results in increased uptake of Lactic Acid			[41]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	kaempferol inhibits the reaction SLC16A1 protein results in increased uptake of Lactic Acid			[66]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	Lactic Acid binds to and results in increased stability of and affects the activity of SLC16A1 protein			[44]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	Lactic Acid co-treated with Deoxyglucose promotes the reaction Cadmium Chloride results in increased abundance of Cadmium which results in increased expression of SLC16A1 protein			[42]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	Lactic Acid inhibits the reaction SLC16A1 protein results in increased uptake of Butyrates			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation10	Ouabain inhibits the reaction SLC16A1 protein results in increased uptake of Lactic Acid			[41]
Regulation Mechanism				Transcription Factor Info
DT Modulation11	p-Chloromercuribenzoic Acid inhibits the reaction SLC16A1 protein results in increased uptake of Lactic Acid			[41]
Regulation Mechanism				Transcription Factor Info
DT Modulation12	Protons promotes the reaction SLC16A1 protein results in increased uptake of Lactic Acid			[41]
Regulation Mechanism				Transcription Factor Info
DT Modulation13	Pyruvic Acid inhibits the reaction SLC16A1 protein results in increased uptake of Lactic Acid			[41]
Regulation Mechanism				Transcription Factor Info
DT Modulation14	Salicylic Acid inhibits the reaction SLC16A1 protein results in increased uptake of Lactic Acid			[41]
Regulation Mechanism				Transcription Factor Info
DT Modulation15	SLC16A1 protein results in increased uptake of Lactic Acid			[41]
Regulation Mechanism				Transcription Factor Info
DT Modulation16	Sodium Azide inhibits the reaction SLC16A1 protein results in increased uptake of Lactic Acid			[41]
Regulation Mechanism				Transcription Factor Info
LDN 193189	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	LDN 193189 co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with FGF2 protein results in decreased expression of SLC16A1 protein			[43]
Regulation Mechanism				Transcription Factor Info
Manganese	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	sodium arsenite results in increased abundance of Arsenic co-treated with manganese chloride results in increased abundance of Manganese results in increased expression of SLC16A1 mRNA			[47]
Regulation Mechanism				Transcription Factor Info
manganese chloride	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	sodium arsenite results in increased abundance of Arsenic co-treated with manganese chloride results in increased abundance of Manganese results in increased expression of SLC16A1 mRNA			[47]
Regulation Mechanism				Transcription Factor Info
methylmercuric chloride	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	methylmercuric chloride results in decreased expression of SLC16A1 mRNA			[67]
Regulation Mechanism				Transcription Factor Info
Methyl Methanesulfonate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Methyl Methanesulfonate results in decreased expression of SLC16A1 mRNA			[30]
Regulation Mechanism				Transcription Factor Info
morin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	morin inhibits the reaction SLC16A1 protein results in increased uptake of Benzoic Acid			[49]
Regulation Mechanism				Transcription Factor Info
motexafin gadolinium	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	motexafin gadolinium affects the reaction Zinc Acetate results in increased expression of SLC16A1 mRNA			[6]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	motexafin gadolinium results in increased expression of SLC16A1 mRNA			[6]
Regulation Mechanism				Transcription Factor Info
naringenin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	naringenin inhibits the reaction SLC16A1 protein results in increased uptake of Benzoic Acid			[49]
Regulation Mechanism				Transcription Factor Info
N-Methyl-3,4-methylenedioxyamphetamine	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	N-Methyl-3,4-methylenedioxyamphetamine affects the reaction SLC16A1 protein results in increased uptake of Butyrates			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of SLC16A1 mRNA			[9]
Regulation Mechanism				Transcription Factor Info
Okadaic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Okadaic Acid results in increased expression of SLC16A1 mRNA			[69]
Regulation Mechanism				Transcription Factor Info
Ouabain	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ouabain inhibits the reaction SLC16A1 protein results in increased uptake of Lactic Acid			[41]
Regulation Mechanism				Transcription Factor Info
p-Chloromercuribenzoic Acid	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	p-Chloromercuribenzoic Acid inhibits the reaction SLC16A1 protein results in increased uptake of Butyrates			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	p-Chloromercuribenzoic Acid inhibits the reaction SLC16A1 protein results in increased uptake of Lactic Acid			[41]
Regulation Mechanism				Transcription Factor Info
potassium chromate(VI)	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	potassium chromate(VI) results in increased expression of SLC16A1 mRNA			[71]
Regulation Mechanism				Transcription Factor Info
pyrogallol 1,3-dimethyl ether	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sodium Chloride co-treated with pyrogallol 1,3-dimethyl ether results in increased expression of and affects the localization of SLC16A1 protein			[64]
Regulation Mechanism				Transcription Factor Info
Pyruvic Acid	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Pyruvic Acid inhibits the reaction SLC16A1 protein results in increased uptake of Butyrates			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Pyruvic Acid inhibits the reaction SLC16A1 protein results in increased uptake of Lactic Acid			[41]
Regulation Mechanism				Transcription Factor Info
Salicylic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Salicylic Acid inhibits the reaction SLC16A1 protein results in increased uptake of Lactic Acid			[41]
Regulation Mechanism				Transcription Factor Info
Silybin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Silybin inhibits the reaction SLC16A1 protein results in increased uptake of Benzoic Acid			[49]
Regulation Mechanism				Transcription Factor Info
sodium arsenite	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	sodium arsenite results in decreased expression of SLC16A1 mRNA			[73]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	sodium arsenite results in increased abundance of Arsenic co-treated with manganese chloride results in increased abundance of Manganese results in increased expression of SLC16A1 mRNA			[47]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	sodium arsenite results in increased abundance of Arsenic which results in increased expression of SLC16A1 mRNA			[47]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	sodium arsenite results in increased expression of SLC16A1 mRNA			[74]
Regulation Mechanism				Transcription Factor Info
Sodium Azide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sodium Azide inhibits the reaction SLC16A1 protein results in increased uptake of Lactic Acid			[41]
Regulation Mechanism				Transcription Factor Info
Sodium Chloride	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sodium Chloride co-treated with Furaldehyde results in decreased expression of and affects the localization of SLC16A1 protein			[64]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Sodium Chloride co-treated with pyrogallol 1,3-dimethyl ether results in increased expression of and affects the localization of SLC16A1 protein			[64]
Regulation Mechanism				Transcription Factor Info
tamibarotene	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	tamibarotene affects the expression of SLC16A1 mRNA			[4]
Regulation Mechanism				Transcription Factor Info
Tetrachlorodibenzodioxin	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Estradiol co-treated with Tetrachlorodibenzodioxin results in decreased expression of SLC16A1 mRNA			[61]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Tetrachlorodibenzodioxin co-treated with Cycloheximide results in increased expression of SLC16A1 mRNA			[36]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Tetrachlorodibenzodioxin results in increased expression of SLC16A1 mRNA			[61]
Regulation Mechanism				Transcription Factor Info
Theophylline	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Theophylline inhibits the reaction SLC16A1 protein results in increased uptake of Butyrates			[9]
Regulation Mechanism				Transcription Factor Info
Thiram	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Thiram results in decreased expression of SLC16A1 mRNA			[75]
Regulation Mechanism				Transcription Factor Info
trichostatin A	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Decitabine co-treated with trichostatin A results in increased expression of SLC16A1 mRNA			[12]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC16A1 mRNA			[33]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	trichostatin A results in increased expression of SLC16A1 mRNA			[12]
Regulation Mechanism				Transcription Factor Info
triphenyl phosphate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	triphenyl phosphate affects the expression of SLC16A1 mRNA			[76]
Regulation Mechanism				Transcription Factor Info
Nanoparticle
perfluoro-n-nonanoic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	perfluoro-n-nonanoic acid results in increased expression of SLC16A1 mRNA			[70]
Regulation Mechanism				Transcription Factor Info
Approved Drug
Aspirin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Aspirin inhibits the expression of SLC16A1			[3]
DT Modulation2	Aspirin affects the reaction SLC16A1 protein results in increased uptake of Butyrates			[9]
Regulation Mechanism				Transcription Factor Info
Alitretinoin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Alitretinoin inhibits the expression of SLC16A1			[5]
Isotretinoin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Isotretinoin inhibits the expression of SLC16A1			[5]
Tretinoin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tretinoin inhibits the expression of SLC16A1			[5]
Zinc Acetate	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Zinc Acetate increases the expression of SLC16A1			[6]
Fluorouracil	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Fluorouracil inhibits the expression of SLC16A1			[7]
Indomethacin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Indomethacin inhibits the expression of SLC16A1			[8]
Caffeine	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Caffeine increases the expression of SLC16A1			[9]
Dronabinol	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Dronabinol increases the expression of SLC16A1			[9]
Hydrogen Peroxide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Hydrogen Peroxide affects the expression of SLC16A1			[10]
Folic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Folic Acid inhibits the expression of SLC16A1			[11]
Decitabine	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Decitabine increases the expression of SLC16A1			[12]
Zoledronic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Zoledronic Acid increases the expression of SLC16A1			[13]
Piroxicam	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Piroxicam increases the expression of SLC16A1			[14]
Zidovudine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Zidovudine inhibits the expression of SLC16A1			[15]
Cyclosporine	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cyclosporine inhibits the expression of SLC16A1			[16]
Panobinostat	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Panobinostat increases the expression of SLC16A1			[17]
Acetaminophen	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Acetaminophen increases the expression of SLC16A1			[18]
Doxorubicin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Doxorubicin increases the expression of SLC16A1			[19]
Sunitinib	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sunitinib inhibits the expression of SLC16A1			[20]
Ivermectin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ivermectin inhibits the expression of SLC16A1			[21]
Estradiol	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Estradiol increases the expression of SLC16A1			[22]
Valproic Acid	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Valproic Acid increases the expression of SLC16A1			[23]
Testosterone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Testosterone induces the activity of SLC16A1			[24]
Nateglinide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Nateglinide inhibits the activity of SLC16A1			[25]
Nicotine polacrilex	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Nicotine induces the activity of SLC16A1			[26]
Niflumic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Niflumic acid inhibits the activity of SLC16A1			[27]
Irbesartan	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Irbesartan inhibits the activity of SLC16A1			[28]
Drug in Phase 2/3 Trial
AM-80	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	AM-80 affects the expression of SLC16A1			[4]
Drug in Phase 2 Trial
Motexafin gadolinium	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Motexafin gadolinium increases the expression of SLC16A1			[6]
Bisphenol A	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Bisphenol A inhibits the expression of SLC16A1			[12]
MS-275	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	MS-275 increases the expression of SLC16A1			[17]
Genistein	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Genistein increases the expression of SLC16A1			[32]
Bisphenol B	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Bisphenol B increases the expression of SLC16A1			[35]
Drug in Phase 1 Trial
CCRIS-9277	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	CCRIS-9277 increases the expression of SLC16A1			[9]
Geldanamycin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Geldanamycin increases the expression of SLC16A1			[31]
Trichostatin A	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Trichostatin A increases the expression of SLC16A1			[17]
Sodium arsenite	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sodium arsenite inhibits the expression of SLC16A1			[37]
Drug in Preclinical Test
Nitric oxide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Nitric oxide induces the activity of SLC16A1			[38]
Investigative Drug
BAY-8002	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	BAY-8002 inhibits the activity of SLC16A1			[2]
Cell System	Human colorectal adenocarcinoma cell lines (DLD-1)-MCT1
Mersalyl	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Mersalyl inhibits the activity of SLC16A1			[39]
Natural Product
Butyric Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Butyric acid induces the transportation of Ferulic acid by SLC16A1			[1]
Affected Drug/Substrate	Ferulic acid	Modulation Type	Inducer
Cell System	Human enterocyte-like 2 cell (Caco-2)-MCT1
DT Modulation1	Caffeine affects the reaction SLC16A1 protein results in increased uptake of Butyrates			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Caffeine results in increased phosphorylation of SLC16A1 protein			[55]
Regulation Mechanism				Transcription Factor Info
4-oxoretinoic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	4-oxoretinoic acid inhibits the expression of SLC16A1			[5]
Tobacco Smoke Pollution	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tobacco Smoke Pollution increases the expression of SLC16A1			[34]
Quercetin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Quercetin inhibits the reaction SLC16A1 protein results in increased uptake of Benzoic Acid			[49]
Regulation Mechanism				Transcription Factor Info
Resveratrol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Plant Extracts co-treated with Resveratrol results in increased expression of SLC16A1 mRNA			[72]
Regulation Mechanism				Transcription Factor Info
Dietary Constituent
Ketogenic diet	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ketogenic diet induces the activity of SLC16A1			[40]
Environmental toxicant
Polychlorinated dibenzodioxin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Polychlorinated dibenzodioxin increases the expression of SLC16A1			[36]
Acute Toxic Substance
Cadmium	6 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cadmium increases the expression of SLC16A1			[29]
Formaldehyde	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Formaldehyde inhibits the expression of SLC16A1			[30]
Thimerosal	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Thimerosal inhibits the expression of SLC16A1			[33]
Carcinogen
DT Modulation1	3-methyladenine inhibits the reaction Cadmium Chloride results in increased abundance of Cadmium which results in increased expression of SLC16A1 protein			[42]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	AZD3965 inhibits the reaction Cadmium Chloride results in increased abundance of Cadmium which results in increased expression of SLC16A1 protein			[42]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Cadmium Chloride results in increased abundance of Cadmium which results in increased expression of SLC16A1 mRNA			[54]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Cadmium Chloride results in increased abundance of Cadmium which results in increased expression of SLC16A1 protein			[42]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Lactic Acid co-treated with Deoxyglucose promotes the reaction Cadmium Chloride results in increased abundance of Cadmium which results in increased expression of SLC16A1 protein			[42]
Regulation Mechanism				Transcription Factor Info
Ethyl Methanesulfonate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ethyl Methanesulfonate inhibits the expression of SLC16A1			[30]
Arsenic	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	sodium arsenite results in increased abundance of Arsenic co-treated with manganese chloride results in increased abundance of Manganese results in increased expression of SLC16A1 mRNA			[47]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	sodium arsenite results in increased abundance of Arsenic which results in increased expression of SLC16A1 mRNA			[47]
Regulation Mechanism				Transcription Factor Info
Nickel	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Nickel results in increased expression of SLC16A1 mRNA			[68]
Regulation Mechanism				Transcription Factor Info

References
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