Detail Information of Exogenous Modulation

General Information of Drug Transporter (DT)
DT ID	DTD0081 Transporter Info
Gene Name	SLC11A2
Transporter Name	Natural resistance-associated macrophage protein 2
Gene ID	4891
UniProt ID	P49281

Exogenous factors (drugs, dietary constituents, etc.) Modulation of This DT (EGM)
Chemical Compound
DT Modulation1	Zinc Sulfate inhibits the reaction Hydrogen Peroxide results in increased expression of SLC11A2 protein		[7]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Zinc Sulfate inhibits the reaction Hydrogen Peroxide results in increased expression of SLC11A2 protein which results in increased uptake of ferric chloride		[7]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	Zinc Sulfate results in increased expression of SLC11A2 protein which results in increased uptake of ferric chloride		[7]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Copper promotes the reaction Estradiol results in increased expression of SLC11A2 mRNA		[6]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Estradiol inhibits the reaction Copper results in decreased expression of SLC11A2 protein		[6]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	Estradiol promotes the reaction Copper affects the expression of SLC11A2 mRNA		[6]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	bathophenanthroline disulfonic acid inhibits the reaction Hydrogen Peroxide results in increased expression of SLC11A2 protein		[7]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	bathophenanthroline disulfonic acid inhibits the reaction Hydrogen Peroxide results in increased expression of SLC11A2 protein which results in increased uptake of ferric chloride		[7]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	Hydrogen Peroxide results in increased expression of SLC11A2 protein which results in increased uptake of ferric chloride		[7]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	Zinc Sulfate inhibits the reaction Hydrogen Peroxide results in increased expression of SLC11A2 protein		[7]
Regulation Mechanism			Transcription Factor Info
DT Modulation5	Zinc Sulfate inhibits the reaction Hydrogen Peroxide results in increased expression of SLC11A2 protein which results in increased uptake of ferric chloride		[7]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Copper promotes the reaction Estradiol results in increased expression of SLC11A2 mRNA		[6]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Copper results in increased expression of SLC11A2 protein		[41]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	Estradiol inhibits the reaction Copper results in decreased expression of SLC11A2 protein		[6]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	Estradiol promotes the reaction Copper affects the expression of SLC11A2 mRNA		[6]
Regulation Mechanism			Transcription Factor Info
DT Modulation5	SLC11A2 protein co-treated with SLC31A1 protein affects the uptake of Copper		[41]
Regulation Mechanism			Transcription Factor Info
DT Modulation6	SLC11A2 protein results in increased transport of Copper		[42]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased expression of SLC11A2 mRNA		[14]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Valproic Acid affects the expression of SLC11A2 mRNA		[65]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Deferoxamine results in increased expression of SLC11A2 protein which results in increased uptake of Manganese		[43]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Manganese inhibits the reaction SLC11A2 protein results in increased transport of Ferrous Compounds		[38]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Selenium co-treated with Vitamin E results in decreased expression of SLC11A2 mRNA		[16]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Benzo(a)pyrene results in decreased methylation of SLC11A2 promoter		[30]
Regulation Mechanism			Transcription Factor Info
2-palmitoylglycerol	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	2-palmitoylglycerol results in increased expression of SLC11A2 mRNA		[26]
Regulation Mechanism			Transcription Factor Info
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased expression of SLC11A2 mRNA		[14]
Regulation Mechanism			Transcription Factor Info
Asbestos, Crocidolite	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Asbestos, Crocidolite results in increased expression of SLC11A2 mRNA		[28]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Asbestos, Crocidolite results in increased expression of SLC11A2 protein		[28]
Regulation Mechanism			Transcription Factor Info
Ascorbic Acid	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Ascorbic Acid results in decreased expression of SLC11A2 protein		[3]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Ascorbic Acid results in increased expression of SLC11A2 protein		[3]
Regulation Mechanism			Transcription Factor Info
astragaloside A	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	astragaloside A inhibits the reaction Iron-Dextran Complex results in increased abundance of Iron which results in increased expression of SLC11A2 protein		[29]
Regulation Mechanism			Transcription Factor Info
azoxystrobin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	azoxystrobin results in decreased expression of SLC11A2 mRNA		[12]
Regulation Mechanism			Transcription Factor Info
bathophenanthroline disulfonic acid	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	bathophenanthroline disulfonic acid inhibits the reaction Hydrogen Peroxide results in increased expression of SLC11A2 protein		[7]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	bathophenanthroline disulfonic acid inhibits the reaction Hydrogen Peroxide results in increased expression of SLC11A2 protein which results in increased uptake of ferric chloride		[7]
Regulation Mechanism			Transcription Factor Info
benzyloxycarbonylleucyl-leucyl-leucine aldehyde	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction PRKN protein results in decreased expression of SLC11A2 protein alternative form		[31]
Regulation Mechanism			Transcription Factor Info
beta-methylcholine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	beta-methylcholine affects the expression of SLC11A2 mRNA		[32]
Regulation Mechanism			Transcription Factor Info
Cadmium Chloride	5 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Cadmium Chloride results in decreased expression of SLC11A2 mRNA		[37]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Cadmium Chloride results in increased abundance of Cadmium which results in decreased expression of SLC11A2 mRNA		[33]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	Cadmium Chloride results in increased abundance of Cadmium which results in decreased expression of SLC11A2 protein		[33]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	Cadmium Chloride results in increased abundance of Cadmium which results in increased expression of SLC11A2 mRNA		[34]
Regulation Mechanism			Transcription Factor Info
DT Modulation5	SLC11A2 protein results in increased transport of Cadmium Chloride		[38]
Regulation Mechanism			Transcription Factor Info
Catechin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Catechin co-treated with Grape Seed Proanthocyanidins results in increased expression of SLC11A2 mRNA		[39]
Regulation Mechanism			Transcription Factor Info
Cobalt	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Cobalt inhibits the reaction SLC11A2 protein results in increased transport of Ferrous Compounds		[38]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	SLC11A2 protein results in increased transport of Cobalt		[38]
Regulation Mechanism			Transcription Factor Info
cobaltous chloride	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	cobaltous chloride results in increased expression of SLC11A2 mRNA		[40]
Regulation Mechanism			Transcription Factor Info
cupric chloride	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	cupric chloride inhibits the reaction SLC11A2 protein results in increased uptake of Iron		[42]
Regulation Mechanism			Transcription Factor Info
Deferiprone	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Deferiprone inhibits the reaction Iron-Dextran Complex results in increased abundance of Iron which results in increased expression of SLC11A2 protein		[29]
Regulation Mechanism			Transcription Factor Info
Deferoxamine	4 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Deferoxamine promotes the reaction Deferoxamine results in increased expression of SLC11A2 protein		[43]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Deferoxamine results in decreased abundance of Iron which results in increased expression of SLC11A2 mRNA		[44]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	Deferoxamine results in increased expression of SLC11A2 protein		[43]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	Deferoxamine results in increased expression of SLC11A2 protein which results in increased uptake of Manganese		[43]
Regulation Mechanism			Transcription Factor Info
deguelin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	deguelin results in decreased expression of SLC11A2 mRNA		[12]
Regulation Mechanism			Transcription Factor Info
deoxynivalenol	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	deoxynivalenol results in decreased expression of SLC11A2 protein		[45]
Regulation Mechanism			Transcription Factor Info
di-n-butylphosphoric acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	di-n-butylphosphoric acid affects the expression of SLC11A2 mRNA		[46]
Regulation Mechanism			Transcription Factor Info
dorsomorphin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased expression of SLC11A2 mRNA		[14]
Regulation Mechanism			Transcription Factor Info
Dronabinol	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Dronabinol inhibits the reaction SLC11A2 protein results in increased uptake of Iron		[47]
Regulation Mechanism			Transcription Factor Info
ebselen	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	ebselen inhibits the reaction SLC11A2 protein results in increased uptake of Iron		[47]
Regulation Mechanism			Transcription Factor Info
excavatolide B	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	excavatolide B results in decreased expression of SLC11A2 protein		[22]
Regulation Mechanism			Transcription Factor Info
ferric chloride	4 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	bathophenanthroline disulfonic acid inhibits the reaction Hydrogen Peroxide results in increased expression of SLC11A2 protein which results in increased uptake of ferric chloride		[7]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Hydrogen Peroxide results in increased expression of SLC11A2 protein which results in increased uptake of ferric chloride		[7]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	Zinc Sulfate inhibits the reaction Hydrogen Peroxide results in increased expression of SLC11A2 protein which results in increased uptake of ferric chloride		[7]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	Zinc Sulfate results in increased expression of SLC11A2 protein which results in increased uptake of ferric chloride		[7]
Regulation Mechanism			Transcription Factor Info
ferric nitrilotriacetate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	ferric nitrilotriacetate results in decreased expression of SLC11A2 mRNA		[48]
Regulation Mechanism			Transcription Factor Info
ferrous sulfate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	ferrous sulfate results in decreased expression of SLC11A2 mRNA		[49]
Regulation Mechanism			Transcription Factor Info
Gasoline	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Gasoline co-treated with isobutyl alcohol results in increased abundance of Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons which results in decreased expression of SLC11A2 mRNA		[50]
Regulation Mechanism			Transcription Factor Info
Glucose	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Glucose deficiency co-treated with Oxygen deficiency results in increased expression of SLC11A2 mRNA alternative form		[51]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Glucose deficiency co-treated with Oxygen deficiency results in increased expression of SLC11A2 protein alternative form		[51]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	Glucose results in increased expression of SLC11A2 protein		[52]
Regulation Mechanism			Transcription Factor Info
isobutyl alcohol	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Gasoline co-treated with isobutyl alcohol results in increased abundance of Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons which results in decreased expression of SLC11A2 mRNA		[50]
Regulation Mechanism			Transcription Factor Info
Isoniazid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Isoniazid results in increased expression of SLC11A2 protein		[55]
Regulation Mechanism			Transcription Factor Info
K 7174	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	K 7174 results in decreased expression of SLC11A2 mRNA		[19]
Regulation Mechanism			Transcription Factor Info
manganese chloride	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	manganese chloride results in increased expression of SLC11A2 mRNA		[1]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	SLC11A2 protein results in increased transport of manganese chloride		[38]
Regulation Mechanism			Transcription Factor Info
Methapyrilene	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Methapyrilene results in increased expression of SLC11A2 mRNA		[57]
Regulation Mechanism			Transcription Factor Info
methylmercuric chloride	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	methylmercuric chloride results in decreased expression of SLC11A2 mRNA		[58]
Regulation Mechanism			Transcription Factor Info
Nitroprusside	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Nitroprusside results in increased abundance of nitrosonium ion which results in decreased expression of SLC11A2 mRNA		[44]
Regulation Mechanism			Transcription Factor Info
nitrosonium ion	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Nitroprusside results in increased abundance of nitrosonium ion which results in decreased expression of SLC11A2 mRNA		[44]
Regulation Mechanism			Transcription Factor Info
nivalenol	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	nivalenol results in decreased expression of SLC11A2 protein		[45]
Regulation Mechanism			Transcription Factor Info
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of SLC11A2 mRNA		[59]
Regulation Mechanism			Transcription Factor Info
Oxygen	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Glucose deficiency co-treated with Oxygen deficiency results in increased expression of SLC11A2 mRNA alternative form		[51]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Glucose deficiency co-treated with Oxygen deficiency results in increased expression of SLC11A2 protein alternative form		[51]
Regulation Mechanism			Transcription Factor Info
Ozone	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Ozone results in increased expression of SLC11A2 mRNA		[61]
Regulation Mechanism			Transcription Factor Info
picoxystrobin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	picoxystrobin results in decreased expression of SLC11A2 mRNA		[12]
Regulation Mechanism			Transcription Factor Info
prolinedithiocarbamate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	prolinedithiocarbamate inhibits the reaction SLC11A2 protein results in increased uptake of Iron		[47]
Regulation Mechanism			Transcription Factor Info
pyrachlostrobin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	pyrachlostrobin results in decreased expression of SLC11A2 mRNA		[12]
Regulation Mechanism			Transcription Factor Info
Selenium	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Selenium co-treated with Vitamin E results in decreased expression of SLC11A2 mRNA		[16]
Regulation Mechanism			Transcription Factor Info
sodium arsenite	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	sodium arsenite results in decreased expression of SLC11A2 mRNA		[37]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	sodium arsenite results in increased abundance of Arsenic which results in decreased expression of SLC11A2 mRNA		[27]
Regulation Mechanism			Transcription Factor Info
Succimer	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Succimer co-treated with Magnetite Nanoparticles results in increased expression of SLC11A2 mRNA		[63]
Regulation Mechanism			Transcription Factor Info
tert-Butylhydroperoxide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	tert-Butylhydroperoxide results in increased expression of SLC11A2 mRNA		[64]
Regulation Mechanism			Transcription Factor Info
Thiram	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Thiram results in decreased expression of SLC11A2 mRNA		[37]
Regulation Mechanism			Transcription Factor Info
trichostatin A	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	trichostatin A results in decreased expression of SLC11A2 mRNA		[20]
Regulation Mechanism			Transcription Factor Info
vanadium dioxide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	SLC11A2 protein results in increased transport of vanadium dioxide		[38]
Regulation Mechanism			Transcription Factor Info
Zinc	4 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	IFNG protein results in increased expression of SLC11A2 mRNA which results in decreased uptake of Zinc		[4]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Lipopolysaccharides results in increased expression of SLC11A2 mRNA which results in decreased uptake of Zinc		[4]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	TNF protein results in increased expression of SLC11A2 mRNA which results in decreased uptake of Zinc		[4]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	Zinc inhibits the reaction SLC11A2 protein results in increased transport of Ferrous Compounds		[38]
Regulation Mechanism			Transcription Factor Info
zinc chloride	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	SLC11A2 protein results in increased transport of zinc chloride		[38]
Regulation Mechanism			Transcription Factor Info
Dietary Constituent
Iron	15 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	astragaloside A inhibits the reaction Iron-Dextran Complex results in increased abundance of Iron which results in increased expression of SLC11A2 protein		[29]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	cupric chloride inhibits the reaction SLC11A2 protein results in increased uptake of Iron		[42]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	Deferiprone inhibits the reaction Iron-Dextran Complex results in increased abundance of Iron which results in increased expression of SLC11A2 protein		[29]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	Deferoxamine results in decreased abundance of Iron which results in increased expression of SLC11A2 mRNA		[44]
Regulation Mechanism			Transcription Factor Info
DT Modulation5	Dronabinol inhibits the reaction SLC11A2 protein results in increased uptake of Iron		[47]
Regulation Mechanism			Transcription Factor Info
DT Modulation6	ebselen inhibits the reaction SLC11A2 protein results in increased uptake of Iron		[47]
Regulation Mechanism			Transcription Factor Info
DT Modulation7	HFE protein binds to B2M protein binds to SLC11A2 protein which results in decreased uptake of Iron		[53]
Regulation Mechanism			Transcription Factor Info
DT Modulation8	Iron-Dextran Complex results in increased abundance of Iron which results in increased expression of SLC11A2 protein		[29]
Regulation Mechanism			Transcription Factor Info
DT Modulation9	Iron results in decreased expression of SLC11A2 protein		[3]
Regulation Mechanism			Transcription Factor Info
DT Modulation10	Iron results in increased expression of SLC11A2 mRNA		[15]
Regulation Mechanism			Transcription Factor Info
DT Modulation11	Iron results in increased expression of SLC11A2 protein		[3]
Regulation Mechanism			Transcription Factor Info
DT Modulation12	prolinedithiocarbamate inhibits the reaction SLC11A2 protein results in increased uptake of Iron		[47]
Regulation Mechanism			Transcription Factor Info
DT Modulation13	SLC11A2 gene SNP affects the abundance of Iron		[54]
Regulation Mechanism			Transcription Factor Info
DT Modulation14	SLC11A2 protein alternative form results in increased uptake of Iron		[51]
Regulation Mechanism			Transcription Factor Info
DT Modulation15	SLC11A2 protein results in increased uptake of Iron		[42]
Regulation Mechanism			Transcription Factor Info
Environmental toxicant
DT Modulation1	HAMP protein results in decreased expression of SLC11A2 mRNA which results in decreased uptake of Mercury		[21]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	SLC11A2 mRNA results in increased uptake of Mercury		[21]
Regulation Mechanism			Transcription Factor Info
Lead	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	SLC11A2 gene SNP affects the abundance of Lead		[54]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	SLC11A2 protein results in increased transport of Lead		[56]
Regulation Mechanism			Transcription Factor Info
Mycotoxins
ochratoxin A	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	ochratoxin A results in decreased expression of SLC11A2 mRNA		[60]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	ochratoxin A results in decreased expression of SLC11A2 protein		[45]
Regulation Mechanism			Transcription Factor Info
Biotoxin
yessotoxin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	yessotoxin analog results in increased expression of SLC11A2 mRNA		[24]
Regulation Mechanism			Transcription Factor Info
Approved Drug
Manganese chloride	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Manganese chloride increases the expression of SLC11A2		[1]
Arsenic	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Arsenic affects the expression of SLC11A2		[2]
Vitamin C	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Vitamin C inhibits the expression of SLC11A2		[3]
Copper Sulfate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Copper Sulfate inhibits the expression of SLC11A2		[5]
Estradiol	4 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Estradiol increases the expression of SLC11A2		[6]
Hydrogen Peroxide	6 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Hydrogen Peroxide increases the expression of SLC11A2		[7]
Isotretinoin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Isotretinoin inhibits the expression of SLC11A2		[8]
Acetaminophen	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Acetaminophen inhibits the expression of SLC11A2		[9]
Zoledronic Acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Zoledronic Acid increases the expression of SLC11A2		[10]
Urethane	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Urethane inhibits the expression of SLC11A2		[11]
Copper	7 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Copper inhibits the expression of SLC11A2		[6]
Cyclosporine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Cyclosporine inhibits the expression of SLC11A2		[13]
Valproic Acid	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Valproic Acid inhibits the expression of SLC11A2		[14]
Drug Marketed but not Approved by US FDA
Zinc Sulfate	4 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Zinc Sulfate increases the expression of SLC11A2		[4]
Rotenone	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Rotenone inhibits the expression of SLC11A2		[12]
Drug in Phase 3 Trial
Vitamin E	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Vitamin E inhibits the expression of SLC11A2		[16]
Drug in Phase 2 Trial
Ethanol	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Ethanol increases the expression of SLC11A2		[18]
Drug in Phase 1 Trial
Quercetin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Quercetin inhibits the expression of SLC11A2		[17]
Trichostatin A	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Trichostatin A inhibits the expression of SLC11A2		[20]
Investigative Drug
Manganese	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Manganese increases the expression of SLC11A2		[1]
PP242	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	PP242 inhibits the expression of SLC11A2		[24]
Patented Pharmaceutical Agent
K-7174	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	K-7174 inhibits the expression of SLC11A2		[19]
Natural Product
Excavatolide B	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Excavatolide B inhibits the expression of SLC11A2		[22]
Tobacco Smoke Pollution	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Tobacco Smoke Pollution affects the expression of SLC11A2		[23]
Deguelin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Deguelin inhibits the expression of SLC11A2		[12]
Resveratrol	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Plant Extracts co-treated with Resveratrol results in increased expression of SLC11A2 mRNA		[62]
Regulation Mechanism			Transcription Factor Info
Acute Toxic Substance
Cadmium	7 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Cadmium inhibits the expression of SLC11A2		[15]
Mercury	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Mercury inhibits the expression of SLC11A2		[21]
Antimycin A	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Antimycin A inhibits the expression of SLC11A2		[12]
Ochratoxin A	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Ochratoxin A inhibits the expression of SLC11A2		[25]
Carcinogen
DT Modulation1	sodium arsenite results in increased abundance of Arsenic which results in decreased expression of SLC11A2 mRNA		[27]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Cadmium Chloride results in increased abundance of Cadmium which results in decreased expression of SLC11A2 mRNA		[33]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Cadmium Chloride results in increased abundance of Cadmium which results in decreased expression of SLC11A2 protein		[33]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	Cadmium Chloride results in increased abundance of Cadmium which results in increased expression of SLC11A2 mRNA		[34]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	SLC11A2 affects the transport of Cadmium		[15]
Regulation Mechanism			Transcription Factor Info
DT Modulation5	SLC11A2 protein affects the uptake of Cadmium		[35]
Regulation Mechanism			Transcription Factor Info
DT Modulation6	SLC11A2 protein results in increased uptake of Cadmium		[36]
Regulation Mechanism			Transcription Factor Info
Benzo(a)pyrene	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Benzo(a)pyrene inhibits the expression of SLC11A2		[17]
Nickel	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	SLC11A2 protein results in increased transport of Nickel		[38]
Regulation Mechanism			Transcription Factor Info
Fungicide
Azoxystrobin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Azoxystrobin inhibits the expression of SLC11A2		[12]
Health and Environmental Toxicant
Nano-sized iron particle	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Nano-sized iron particle inhibits the expression of SLC11A2		[3]

References
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