Detail Information of Exogenous Modulation

General Information of Drug Transporter (DT)
DT ID DTD0065 Transporter Info
Gene Name ABCD3
Transporter Name ATP-binding cassette sub-family D member 3
Gene ID
5825
UniProt ID
P28288
Exogenous factors (drugs, dietary constituents, etc.) Modulation of This DT (EGM)

Chemical Compound

  DT Modulation1

 Estradiol co-treated with Progesterone results in increased expression of ABCD3 mRNA [42]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation1

 Testosterone co-treated with Calcitriol results in increased expression of ABCD3 mRNA [4]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation1

 Testosterone co-treated with Calcitriol results in increased expression of ABCD3 mRNA [4]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation1

 Tretinoin results in increased expression of ABCD3 mRNA [49]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation1

 NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of ABCD3 mRNA [6]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation2

 Valproic Acid affects the expression of ABCD3 mRNA [50]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation1

 NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of ABCD3 mRNA [6]

Regulation Mechanism

 Transcription Factor Info

  2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of ABCD3 mRNA [17]

Regulation Mechanism

 Transcription Factor Info

  2-bromopalmitate

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 2-bromopalmitate inhibits the reaction Cadmium Chloride results in increased abundance of Cadmium which results in increased palmitoylation of ABCD3 protein [31]

Regulation Mechanism

 Transcription Factor Info

  2-palmitoylglycerol

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 2-palmitoylglycerol results in increased expression of ABCD3 mRNA [32]

Regulation Mechanism

 Transcription Factor Info

  4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide

            2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of ABCD3 mRNA [6]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation2

 NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of ABCD3 mRNA [6]

Regulation Mechanism

 Transcription Factor Info

  abrine

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 abrine results in decreased expression of ABCD3 mRNA [33]

Regulation Mechanism

 Transcription Factor Info

  Arachidonic Acid

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Arachidonic Acid results in decreased expression of ABCD3 mRNA [14]

Regulation Mechanism

 Transcription Factor Info

  aristolochic acid I

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 aristolochic acid I results in decreased expression of ABCD3 mRNA [35]

Regulation Mechanism

 Transcription Factor Info

  bisphenol B

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 bisphenol B results in increased expression of ABCD3 protein [30]

Regulation Mechanism

 Transcription Factor Info

  bisphenol S

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 bisphenol S affects the expression of ABCD3 protein [36]

Regulation Mechanism

 Transcription Factor Info

  Cadmium Chloride

            3 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 2-bromopalmitate inhibits the reaction Cadmium Chloride results in increased abundance of Cadmium which results in increased palmitoylation of ABCD3 protein [31]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation2

 Cadmium Chloride results in increased abundance of Cadmium which results in increased expression of ABCD3 mRNA [37]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation3

 Cadmium Chloride results in increased abundance of Cadmium which results in increased palmitoylation of ABCD3 protein [31]

Regulation Mechanism

 Transcription Factor Info

  Catechin

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Catechin co-treated with Grape Seed Proanthocyanidins results in decreased expression of ABCD3 mRNA [38]

Regulation Mechanism

 Transcription Factor Info

  clothianidin

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 clothianidin results in decreased expression of ABCD3 mRNA [29]

Regulation Mechanism

 Transcription Factor Info

  Copper

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 AP1S1 gene mutant form affects the metabolism of Copper which results in decreased expression of ABCD3 protein [39]

Regulation Mechanism

 Transcription Factor Info

  dicrotophos

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 dicrotophos results in decreased expression of ABCD3 mRNA [25]

Regulation Mechanism

 Transcription Factor Info

  di-n-butylphosphoric acid

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 di-n-butylphosphoric acid affects the expression of ABCD3 mRNA [40]

Regulation Mechanism

 Transcription Factor Info

  dorsomorphin

            2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of ABCD3 mRNA [6]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation2

 NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of ABCD3 mRNA [6]

Regulation Mechanism

 Transcription Factor Info

  epigallocatechin gallate

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 potassium chromate(VI) co-treated with epigallocatechin gallate results in decreased expression of ABCD3 mRNA [41]

Regulation Mechanism

 Transcription Factor Info

  FR900359

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 FR900359 results in decreased phosphorylation of ABCD3 protein [43]

Regulation Mechanism

 Transcription Factor Info

  ICG 001

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 ICG 001 results in decreased expression of ABCD3 mRNA [23]

Regulation Mechanism

 Transcription Factor Info

  Lactic Acid

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Lactic Acid results in decreased expression of ABCD3 mRNA [27]

Regulation Mechanism

 Transcription Factor Info

  Methyl Methanesulfonate

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Methyl Methanesulfonate results in increased expression of ABCD3 mRNA [20]

Regulation Mechanism

 Transcription Factor Info

  potassium chromate(VI)

            2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 potassium chromate(VI) co-treated with epigallocatechin gallate results in decreased expression of ABCD3 mRNA [41]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation2

 potassium chromate(VI) results in decreased expression of ABCD3 mRNA [41]

Regulation Mechanism

 Transcription Factor Info

  Progesterone

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Estradiol co-treated with Progesterone results in increased expression of ABCD3 mRNA [42]

Regulation Mechanism

 Transcription Factor Info

  sodium arsenite

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 sodium arsenite results in increased expression of ABCD3 mRNA [26]

Regulation Mechanism

 Transcription Factor Info

  Thiram

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Thiram results in decreased expression of ABCD3 mRNA [47]

Regulation Mechanism

 Transcription Factor Info

  Topotecan

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 ABCD3 protein affects the susceptibility to Topotecan [48]

Regulation Mechanism

 Transcription Factor Info

  triacsin C

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 triacsin C results in decreased expression of ABCD3 mRNA [14]

Regulation Mechanism

 Transcription Factor Info

  trichostatin A

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 trichostatin A results in increased expression of ABCD3 mRNA [6]

Regulation Mechanism

 Transcription Factor Info

  triphenyl phosphate

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 triphenyl phosphate affects the expression of ABCD3 mRNA [40]

Regulation Mechanism

 Transcription Factor Info

  Vincristine

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Vincristine results in decreased susceptibility to Vincristine which results in decreased expression of ABCD3 mRNA [51]

Regulation Mechanism

 Transcription Factor Info

Carcinogen

  Cadmium

            3 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 2-bromopalmitate inhibits the reaction Cadmium Chloride results in increased abundance of Cadmium which results in increased palmitoylation of ABCD3 protein [31]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation2

 Cadmium Chloride results in increased abundance of Cadmium which results in increased expression of ABCD3 mRNA [37]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation3

 Cadmium Chloride results in increased abundance of Cadmium which results in increased palmitoylation of ABCD3 protein [31]

Regulation Mechanism

 Transcription Factor Info

  Nickel

            2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Nickel results in decreased expression of ABCD3 mRNA [44]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation2

 Nickel results in increased expression of ABCD3 mRNA [45]

Regulation Mechanism

 Transcription Factor Info

Approved Drug

  Estradiol

            2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Estradiol affects the expression of ABCD3 [1]

  Methotrexate

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Methotrexate increases the expression of ABCD3 [2]

  Copper Sulfate

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Copper Sulfate inhibits the expression of ABCD3 [3]

  Calcitriol

            2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Calcitriol increases the expression of ABCD3 [4]

  Testosterone

            2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Testosterone inhibits the expression of ABCD3 [4]

  Piroxicam

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Piroxicam inhibits the expression of ABCD3 [5]

  Vorinostat

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Vorinostat increases the expression of ABCD3 [6]

  Temozolomide

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Temozolomide increases the expression of ABCD3 [7]

  Ivermectin

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Ivermectin inhibits the expression of ABCD3 [8]

  Tretinoin

            2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Tretinoin inhibits the expression of ABCD3 [9]

  Sirolimus

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Sirolimus inhibits the expression of ABCD3 [10]

  Cyclosporine

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Cyclosporine inhibits the expression of ABCD3 [11]

  Valproic Acid

            3 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Valproic Acid increases the expression of ABCD3 [12]

  Leflunomide

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Leflunomide inhibits the expression of ABCD3 [13]

Drug in Phase 2 Trial

  MeIQx

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 MeIQx increases the expression of ABCD3 [17]

  Bisphenol B

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Bisphenol B increases the expression of ABCD3 [30]

Drug in Phase 1 Trial

  Quercetin

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Quercetin inhibits the expression of ABCD3 [18]

  Trichostatin A

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Trichostatin A increases the expression of ABCD3 [6]

  Sodium arsenite

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Sodium arsenite increases the expression of ABCD3 [26]

Drug in Preclinical Test

  (+)-JQ1

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 (+)-JQ1 increases the expression of ABCD3 [22]

Investigative Drug

  Arachidonic acid

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Arachidonic acid inhibits the expression of ABCD3 [14]

  Coumestrol

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Coumestrol inhibits the expression of ABCD3 [15]

  Phenylmercuric Acetate

            2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Phenylmercuric Acetate increases the expression of ABCD3 [24]

  Milchsaure

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Milchsaure inhibits the expression of ABCD3 [27]

Patented Pharmaceutical Agent

  ICG-001

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 ICG-001 inhibits the expression of ABCD3 [23]

Natural Product

  Particulate Matter

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Particulate Matter increases the expression of ABCD3 [21]

  Resveratrol

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Plant Extracts co-treated with Resveratrol results in increased expression of ABCD3 mRNA [46]

Regulation Mechanism

 Transcription Factor Info

Mycotoxins

  Aflatoxin M1

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Aflatoxin M1 inhibits the expression of ABCD3 [28]

  Aflatoxin B1

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Aflatoxin B1 results in decreased methylation of ABCD3 gene [34]

Regulation Mechanism

 Transcription Factor Info

Acute Toxic Substance

  Sarin

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Sarin inhibits the expression of ABCD3 [16]

  Formaldehyde

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Formaldehyde increases the expression of ABCD3 [20]

Pesticide/Insecticide

  Dicrotophos

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Dicrotophos inhibits the expression of ABCD3 [25]

  Clothianidin

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Clothianidin inhibits the expression of ABCD3 [29]

Herbicide

  Atrazine

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Atrazine inhibits the expression of ABCD3 [19]
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