Detail Information of Exogenous Modulation

General Information of Drug Transporter (DT)
DT ID	DTD0031 Transporter Info
Gene Name	SLCO2B1
Transporter Name	Organic anion transporting polypeptide 2B1
Gene ID	11309
UniProt ID	O94956

Exogenous factors (drugs, dietary constituents, etc.) Modulation of This DT (EGM)
Chemical Compound
DT Modulation1	Cyclosporine affects the expression of SLCO2B1 mRNA			[36]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Cyclosporine inhibits the reaction SLCO2B1 protein results in increased uptake of Mesalamine			[22]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Cyclosporine inhibits the reaction SLCO2B1 protein results in increased uptake of Quercetin			[71]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Cyclosporine inhibits the reaction SLCO2B1 protein results in increased uptake of Sulfobromophthalein			[22]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Cyclosporine results in decreased expression of SLCO2B1 mRNA			[60]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Cyclosporine results in increased expression of SLCO2B1 mRNA			[72]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Budesonide inhibits the reaction SLCO2B1 protein results in increased uptake of Mesalamine			[22]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Budesonide inhibits the reaction SLCO2B1 protein results in increased uptake of Sulfobromophthalein			[22]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Carbamazepine results in increased expression of SLCO2B1 mRNA			[67]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Rutin promotes the reaction SLCO2B1 protein results in increased uptake of Cholic Acid			[69]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	SLCO2B1 protein results in increased uptake of Cholic Acid			[69]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Etoposide inhibits the reaction SLCO2B1 protein results in increased uptake of Cascade Blue			[66]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Fenofibrate results in decreased expression of SLCO2B1 mRNA			[36]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	SLCO2B1 protein affects the import of Fluvastatin			[77]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Glyburide inhibits the reaction SLCO2B1 protein results in increased uptake of Atorvastatin			[63]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Irinotecan inhibits the reaction SLCO2B1 protein results in increased uptake of Cascade Blue			[66]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Methotrexate inhibits the reaction SLCO2B1 protein results in increased uptake of Cascade Blue			[66]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Phenobarbital affects the expression of SLCO2B1 mRNA			[83]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Phenobarbital results in decreased expression of SLCO2B1 mRNA			[84]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Phenobarbital results in increased expression of SLCO2B1 protein			[85]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Pioglitazone affects the reaction SLCO2B1 protein results in increased uptake of Sulfobromophthalein			[63]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Pravastatin inhibits the reaction SLCO2B1 protein results in increased uptake of Mesalamine			[22]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Pravastatin inhibits the reaction SLCO2B1 protein results in increased uptake of Sulfobromophthalein			[22]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Rutin promotes the reaction SLCO2B1 protein results in increased uptake of Rosuvastatin Calcium			[69]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	SLCO2B1 protein results in increased uptake of Rosuvastatin Calcium			[69]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Tamoxifen inhibits the reaction SLCO2B1 protein results in increased uptake of Cascade Blue			[66]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Thiotepa inhibits the reaction SLCO2B1 protein results in increased uptake of Cascade Blue			[66]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Valproic Acid affects the expression of SLCO2B1 mRNA			[91]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Zidovudine results in decreased expression of SLCO2B1 mRNA			[94]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Zidovudine results in increased expression of SLCO2B1 mRNA			[94]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Estradiol results in decreased expression of SLCO2B1 mRNA			[60]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Rosiglitazone inhibits the reaction SLCO2B1 protein results in increased uptake of Atorvastatin			[63]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Rifampin inhibits the reaction Dextran Sulfate results in increased expression of SLCO2B1 mRNA			[74]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Rifampin inhibits the reaction Lipopolysaccharides results in increased expression of SLCO2B1 mRNA			[74]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Rifampin inhibits the reaction SLCO2B1 protein results in increased uptake of Mesalamine			[22]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Rifampin inhibits the reaction SLCO2B1 protein results in increased uptake of Sulfobromophthalein			[22]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Rifampin results in decreased expression of SLCO2B1 mRNA			[74]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Rifampin results in decreased expression of SLCO2B1 protein			[74]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Meclizine promotes the reaction Ethanol results in increased expression of SLCO2B1 mRNA			[41]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Meclizine promotes the reaction Ethanol results in increased expression of SLCO2B1 mRNA			[41]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	NR1I2 protein affects the reaction Ethanol results in increased expression of SLCO2B1 mRNA			[41]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Benzo(a)pyrene affects the methylation of SLCO2B1 promoter			[65]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Benzo(a)pyrene results in decreased methylation of SLCO2B1 3' UTR			[65]
Regulation Mechanism				Transcription Factor Info
2,2',4,4',5,6'-hexabromodiphenyl ether	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	2,2',4,4',5,6'-hexabromodiphenyl ether inhibits the reaction SLCO2B1 results in increased import of estrone sulfate			[56]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	SLCO2B1 results in increased import of 2,2',4,4',5,6'-hexabromodiphenyl ether			[56]
Regulation Mechanism				Transcription Factor Info
2,2',4,4'-tetrabromodiphenyl ether	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	2,2',4,4'-tetrabromodiphenyl ether inhibits the reaction SLCO2B1 results in increased import of estrone sulfate			[56]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	SLCO2B1 results in increased import of 2,2',4,4'-tetrabromodiphenyl ether			[56]
Regulation Mechanism				Transcription Factor Info
4-(4-guanidinobenzoyloxy)phenylacetic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	4-(4-guanidinobenzoyloxy)phenylacetic acid results in decreased activity of SLCO2B1 protein			[57]
Regulation Mechanism				Transcription Factor Info
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	LDN 193189 co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with EGF protein co-treated with FGF2 protein results in increased expression of SLCO2B1 mRNA			[58]
Regulation Mechanism				Transcription Factor Info
9,10-dihydro-9,10-dihydroxybenzo(a)pyrene	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	9,10-dihydro-9,10-dihydroxybenzo(a)pyrene results in decreased expression of SLCO2B1 mRNA			[59]
Regulation Mechanism				Transcription Factor Info
adefovir dipivoxil	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	adefovir dipivoxil results in increased expression of SLCO2B1 mRNA			[36]
Regulation Mechanism				Transcription Factor Info
Amiodarone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLCO2B1 protein results in increased uptake of Amiodarone			[61]
Regulation Mechanism				Transcription Factor Info
arsenic pentoxide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	arsenic pentoxide results in decreased expression of SLCO2B1 mRNA			[62]
Regulation Mechanism				Transcription Factor Info
ascorbate-2-phosphate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ascorbate-2-phosphate co-treated with Chir 99021 co-treated with XAV939 co-treated with BMP4 protein co-treated with INHBA protein binds to INHBA protein results in increased expression of SLCO2B1 mRNA			[58]
Regulation Mechanism				Transcription Factor Info
Ascorbic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ascorbic Acid co-treated with Chir 99021 co-treated with XAV939 co-treated with BMP4 protein co-treated with FGF1 protein co-treated with WNT3A protein co-treated with HGF protein co-treated with INHBA protein binds to INHBA protein results in increased expression of SLCO2B1 mRNA			[58]
Regulation Mechanism				Transcription Factor Info
bisphenol A	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	bisphenol A affects the expression of SLCO2B1 mRNA			[52]
Regulation Mechanism				Transcription Factor Info
Bleomycin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Bleomycin inhibits the reaction SLCO2B1 protein results in increased uptake of Cascade Blue			[66]
Regulation Mechanism				Transcription Factor Info
Capecitabine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Capecitabine inhibits the reaction SLCO2B1 protein results in increased uptake of Cascade Blue			[66]
Regulation Mechanism				Transcription Factor Info
Cascade Blue	10 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Bleomycin inhibits the reaction SLCO2B1 protein results in increased uptake of Cascade Blue			[66]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Capecitabine inhibits the reaction SLCO2B1 protein results in increased uptake of Cascade Blue			[66]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Docetaxel inhibits the reaction SLCO2B1 protein results in increased uptake of Cascade Blue			[66]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Etoposide inhibits the reaction SLCO2B1 protein results in increased uptake of Cascade Blue			[66]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Irinotecan inhibits the reaction SLCO2B1 protein results in increased uptake of Cascade Blue			[66]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Methotrexate inhibits the reaction SLCO2B1 protein results in increased uptake of Cascade Blue			[66]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	SLCO2B1 protein results in increased uptake of Cascade Blue			[66]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	Tamoxifen inhibits the reaction SLCO2B1 protein results in increased uptake of Cascade Blue			[66]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	Teniposide inhibits the reaction SLCO2B1 protein results in increased uptake of Cascade Blue			[66]
Regulation Mechanism				Transcription Factor Info
DT Modulation10	Thiotepa inhibits the reaction SLCO2B1 protein results in increased uptake of Cascade Blue			[66]
Regulation Mechanism				Transcription Factor Info
CGP 52608	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	CGP 52608 promotes the reaction RORA protein binds to SLCO2B1 gene			[68]
Regulation Mechanism				Transcription Factor Info
Chir 99021	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ascorbate-2-phosphate co-treated with Chir 99021 co-treated with XAV939 co-treated with BMP4 protein co-treated with INHBA protein binds to INHBA protein results in increased expression of SLCO2B1 mRNA			[58]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Ascorbic Acid co-treated with Chir 99021 co-treated with XAV939 co-treated with BMP4 protein co-treated with FGF1 protein co-treated with WNT3A protein co-treated with HGF protein co-treated with INHBA protein binds to INHBA protein results in increased expression of SLCO2B1 mRNA			[58]
Regulation Mechanism				Transcription Factor Info
cobaltous chloride	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	cobaltous chloride results in increased expression of SLCO2B1 mRNA			[70]
Regulation Mechanism				Transcription Factor Info
daidzein	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	daidzein inhibits the reaction SLCO2B1 protein results in increased transport of estrone sulfate			[73]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	daidzein metabolite inhibits the reaction SLCO2B1 protein results in increased transport of estrone sulfate			[73]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	estrone sulfate inhibits the reaction SLCO2B1 protein results in increased transport of daidzein metabolite			[73]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	SLCO2B1 protein results in increased transport of daidzein metabolite			[73]
Regulation Mechanism				Transcription Factor Info
Dextran Sulfate	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Dextran Sulfate results in increased expression of SLCO2B1 mRNA			[74]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Dextran Sulfate results in increased expression of SLCO2B1 protein			[74]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Rifampin inhibits the reaction Dextran Sulfate results in increased expression of SLCO2B1 mRNA			[74]
Regulation Mechanism				Transcription Factor Info
Docetaxel	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Docetaxel inhibits the reaction SLCO2B1 protein results in increased uptake of Cascade Blue			[66]
Regulation Mechanism				Transcription Factor Info
estrone sulfate	15 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	2,2',4,4',5,6'-hexabromodiphenyl ether inhibits the reaction SLCO2B1 results in increased import of estrone sulfate			[56]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	2,2',4,4'-tetrabromodiphenyl ether inhibits the reaction SLCO2B1 results in increased import of estrone sulfate			[56]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	daidzein inhibits the reaction SLCO2B1 protein results in increased transport of estrone sulfate			[73]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	daidzein metabolite inhibits the reaction SLCO2B1 protein results in increased transport of estrone sulfate			[73]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	estrone sulfate inhibits the reaction SLCO2B1 protein results in increased transport of daidzein metabolite			[73]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	estrone sulfate inhibits the reaction SLCO2B1 protein results in increased uptake of Quercetin			[71]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	icariin results in decreased activity of SLCO2B1 protein which results in decreased uptake of estrone sulfate			[46]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	Mefloquine affects the reaction SLCO2B1 protein results in increased uptake of estrone sulfate			[75]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	pentabromodiphenyl ether inhibits the reaction SLCO2B1 results in increased import of estrone sulfate			[56]
Regulation Mechanism				Transcription Factor Info
DT Modulation10	Rutin promotes the reaction SLCO2B1 protein results in increased uptake of estrone sulfate			[69]
Regulation Mechanism				Transcription Factor Info
DT Modulation11	SLCO2B1 protein results in increased import of estrone sulfate			[76]
Regulation Mechanism				Transcription Factor Info
DT Modulation12	SLCO2B1 protein results in increased uptake of estrone sulfate			[69]
Regulation Mechanism				Transcription Factor Info
DT Modulation13	SLCO2B1 results in increased import of estrone sulfate			[56]
Regulation Mechanism				Transcription Factor Info
DT Modulation14	Sulfobromophthalein inhibits the reaction SLCO2B1 protein results in increased import of estrone sulfate			[19]
Regulation Mechanism				Transcription Factor Info
DT Modulation15	Tobacco Smoke Pollution inhibits the reaction SLCO2B1 protein results in increased import of estrone sulfate			[19]
Regulation Mechanism				Transcription Factor Info
glimepiride	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	glimepiride inhibits the reaction SLCO2B1 protein results in increased uptake of Atorvastatin			[63]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	glimepiride inhibits the reaction SLCO2B1 protein results in increased uptake of Sulfobromophthalein			[63]
Regulation Mechanism				Transcription Factor Info
heliotrine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	heliotrine results in decreased expression of SLCO2B1 mRNA			[48]
Regulation Mechanism				Transcription Factor Info
icariin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	icariin results in decreased activity of SLCO2B1 protein			[46]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	icariin results in decreased activity of SLCO2B1 protein which results in decreased uptake of estrone sulfate			[46]
Regulation Mechanism				Transcription Factor Info
LDN 193189	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	LDN 193189 co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with EGF protein co-treated with FGF2 protein results in increased expression of SLCO2B1 mRNA			[58]
Regulation Mechanism				Transcription Factor Info
Mefloquine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Mefloquine affects the reaction SLCO2B1 protein results in increased uptake of estrone sulfate			[75]
Regulation Mechanism				Transcription Factor Info
Mesalamine	6 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Budesonide inhibits the reaction SLCO2B1 protein results in increased uptake of Mesalamine			[22]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Cyclosporine inhibits the reaction SLCO2B1 protein results in increased uptake of Mesalamine			[22]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Pravastatin inhibits the reaction SLCO2B1 protein results in increased uptake of Mesalamine			[22]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Rifampin inhibits the reaction SLCO2B1 protein results in increased uptake of Mesalamine			[22]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	SLCO2B1 protein affects the uptake of Mesalamine			[78]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	SLCO2B1 protein results in increased uptake of Mesalamine			[22]
Regulation Mechanism				Transcription Factor Info
methyleugenol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	methyleugenol results in decreased expression of SLCO2B1 mRNA			[54]
Regulation Mechanism				Transcription Factor Info
Nateglinide	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Nateglinide inhibits the reaction SLCO2B1 protein results in increased uptake of Atorvastatin			[63]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Nateglinide inhibits the reaction SLCO2B1 protein results in increased uptake of Sulfobromophthalein			[63]
Regulation Mechanism				Transcription Factor Info
nitenpyram	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	nitenpyram results in increased activity of SLCO2B1 protein			[79]
Regulation Mechanism				Transcription Factor Info
Oxygen	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Oxygen deficiency results in increased expression of SLCO2B1 mRNA			[36]
Regulation Mechanism				Transcription Factor Info
pentabromodiphenyl ether	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	pentabromodiphenyl ether inhibits the reaction SLCO2B1 results in increased import of estrone sulfate			[56]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	SLCO2B1 results in increased import of pentabromodiphenyl ether			[56]
Regulation Mechanism				Transcription Factor Info
perfluorobutanesulfonic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLCO2B1 protein results in increased transport of perfluorobutanesulfonic acid			[81]
Regulation Mechanism				Transcription Factor Info
perfluorohexanesulfonic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLCO2B1 protein results in increased transport of perfluorohexanesulfonic acid			[81]
Regulation Mechanism				Transcription Factor Info
perfluorooctane sulfonic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLCO2B1 protein results in increased transport of perfluorooctane sulfonic acid			[81]
Regulation Mechanism				Transcription Factor Info
repaglinide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	repaglinide inhibits the reaction SLCO2B1 protein results in increased uptake of Atorvastatin			[63]
Regulation Mechanism				Transcription Factor Info
Rutin	5 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Rutin affects the localization of SLCO2B1 protein			[69]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Rutin promotes the reaction SLCO2B1 protein results in increased uptake of Cholic Acid			[69]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Rutin promotes the reaction SLCO2B1 protein results in increased uptake of estrone sulfate			[69]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Rutin promotes the reaction SLCO2B1 protein results in increased uptake of Rosuvastatin Calcium			[69]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Rutin promotes the reaction SLCO2B1 protein results in increased uptake of Taurocholic Acid			[69]
Regulation Mechanism				Transcription Factor Info
S-(1,2-dichlorovinyl)cysteine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	S-(1,2-dichlorovinyl)cysteine affects the susceptibility to Lipopolysaccharides which results in increased expression of SLCO2B1 mRNA			[87]
Regulation Mechanism				Transcription Factor Info
senkirkine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	senkirkine results in decreased expression of SLCO2B1 mRNA			[48]
Regulation Mechanism				Transcription Factor Info
sodium arsenite	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	sodium arsenite affects the methylation of SLCO2B1 gene			[88]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	sodium arsenite results in decreased expression of SLCO2B1 mRNA			[50]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	sodium arsenite results in increased expression of SLCO2B1 mRNA			[89]
Regulation Mechanism				Transcription Factor Info
sodium bichromate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	sodium bichromate results in decreased expression of SLCO2B1 mRNA			[45]
Regulation Mechanism				Transcription Factor Info
Sulfobromophthalein	12 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Budesonide inhibits the reaction SLCO2B1 protein results in increased uptake of Sulfobromophthalein			[22]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Cyclosporine inhibits the reaction SLCO2B1 protein results in increased uptake of Sulfobromophthalein			[22]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	glimepiride inhibits the reaction SLCO2B1 protein results in increased uptake of Sulfobromophthalein			[63]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Nateglinide inhibits the reaction SLCO2B1 protein results in increased uptake of Sulfobromophthalein			[63]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Pioglitazone affects the reaction SLCO2B1 protein results in increased uptake of Sulfobromophthalein			[63]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Pravastatin inhibits the reaction SLCO2B1 protein results in increased uptake of Sulfobromophthalein			[22]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	Rifampin inhibits the reaction SLCO2B1 protein results in increased uptake of Sulfobromophthalein			[22]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	SLCO2B1 protein affects the import of Sulfobromophthalein			[77]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	SLCO2B1 protein results in increased uptake of Sulfobromophthalein			[22]
Regulation Mechanism				Transcription Factor Info
DT Modulation10	Sulfobromophthalein inhibits the reaction SLCO2B1 protein results in increased import of estrone sulfate			[19]
Regulation Mechanism				Transcription Factor Info
DT Modulation11	Sulfobromophthalein inhibits the reaction SLCO2B1 protein results in increased uptake of Atorvastatin			[64]
Regulation Mechanism				Transcription Factor Info
DT Modulation12	Sulfobromophthalein results in decreased activity of SLCO2B1 protein			[79]
Regulation Mechanism				Transcription Factor Info
Taurocholic Acid	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Rutin promotes the reaction SLCO2B1 protein results in increased uptake of Taurocholic Acid			[69]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	SLCO2B1 protein results in increased uptake of Taurocholic Acid			[69]
Regulation Mechanism				Transcription Factor Info
Teniposide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Teniposide inhibits the reaction SLCO2B1 protein results in increased uptake of Cascade Blue			[66]
Regulation Mechanism				Transcription Factor Info
Tetrachlorodibenzodioxin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tetrachlorodibenzodioxin results in decreased expression of SLCO2B1 mRNA			[84]
Regulation Mechanism				Transcription Factor Info
theaflavin-3,3'-digallate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	theaflavin-3,3'-digallate affects the expression of SLCO2B1 mRNA			[90]
Regulation Mechanism				Transcription Factor Info
Vanadium	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Vanadium results in increased expression of SLCO2B1 mRNA			[92]
Regulation Mechanism				Transcription Factor Info
XAV939	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ascorbate-2-phosphate co-treated with Chir 99021 co-treated with XAV939 co-treated with BMP4 protein co-treated with INHBA protein binds to INHBA protein results in increased expression of SLCO2B1 mRNA			[58]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Ascorbic Acid co-treated with Chir 99021 co-treated with XAV939 co-treated with BMP4 protein co-treated with FGF1 protein co-treated with WNT3A protein co-treated with HGF protein co-treated with INHBA protein binds to INHBA protein results in increased expression of SLCO2B1 mRNA			[58]
Regulation Mechanism				Transcription Factor Info
zearalenol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	zearalenol results in decreased activity of SLCO2B1 protein			[93]
Regulation Mechanism				Transcription Factor Info
Nanoparticle
perfluoro-n-nonanoic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	perfluoro-n-nonanoic acid results in decreased expression of SLCO2B1 mRNA			[82]
Regulation Mechanism				Transcription Factor Info
Approved Drug
Quercetin	6 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Quercetin inhibits the transportation of Atorvastatin by SLCO2B1 (IC50 = 14.1 microM; Ki = 20.8 microM)			[1]
Affected Drug/Substrate	Atorvastatin	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
DT Modulation2	Quercetin inhibits the transportation of Estrone sulfate by SLCO2B1 (IC50 = 9.47 microM)			[4]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Xenopus laevis oocytes-OATP2B1
DT Modulation3	Quercetin inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Rifamycin SV	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Rifamycin SV inhibits the transportation of Bromsulphthalein by SLCO2B1 (Ki = 3 microM)			[8]
Affected Drug/Substrate	Bromsulphthalein	Modulation Type	Inhibition
Cell System	Oocytes-OATP2B1
DT Modulation2	Rifamycin SV inhibits the transportation of Estrone sulfate by SLCO2B1 (IC50 = 3 microM; Ki = 2.3 microM)			[3]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human enterocyte-like 2 cell (Caco-2)-OATP2B1
DT Modulation3	Rifamycin SV inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Cyclosporine	9 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cyclosporine inhibits the transportation of Bromsulphthalein by SLCO2B1 (IC50 = 20 microM)			[9]
Affected Drug/Substrate	Bromsulphthalein	Modulation Type	Inhibition
Cell System	Madin Darby canine kidney strain II (MDCKII) cells-OATP2B1
DT Modulation2	Cyclosporine inhibits the transportation of Rosuvastatin by SLCO2B1 (IC50 = 0.07 microM)			[10]
Affected Drug/Substrate	Rosuvastatin	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
DT Modulation3	Cyclosporine inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Rifampicin	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Rifampicin inhibits the transportation of Bromsulphthalein by SLCO2B1 (IC50 = 90 microM)			[9]
Affected Drug/Substrate	Bromsulphthalein	Modulation Type	Inhibition
Cell System	Madin Darby canine kidney strain II (MDCKII) cells-OATP2B1
DT Modulation2	Rifampicin inhibits the transportation of Estrone sulfate by SLCO2B1 (IC50 = 2.1 microM; Ki = 1.6 microM)			[3]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human enterocyte-like 2 cell (Caco-2)-OATP2B1
DT Modulation3	Rifampicin inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Hesperetin	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Hesperetin inhibits the transportation of Estrone sulfate by SLCO2B1 (IC50 = 67.6 microM)			[4]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Xenopus laevis oocytes-OATP2B1
DT Modulation2	Hesperetin inhibits the transportation of Estrone sulfate by SLCO2B1 (IC50 = 1.92 microM)			[4]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Xenopus laevis oocytes-OATP2B1
DT Modulation3	Hesperetin inhibits the transportation of Estrone sulfate by SLCO2B1			[11]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Xenopus laevis oocytes-OATP2B1
Paclitaxel	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Paclitaxel inhibits the transportation of Bromsulphthalein by SLCO2B1 (IC50 = 25 microM)			[9]
Affected Drug/Substrate	Bromsulphthalein	Modulation Type	Inhibition
Cell System	Madin Darby canine kidney strain II (MDCKII) cells-OATP2B1
DT Modulation2	Paclitaxel inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Repaglinide	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Repaglinide inhibits the transportation of Bromsulphthalein by SLCO2B1 (IC50 = 5.2 microM)			[15]
Affected Drug/Substrate	Bromsulphthalein	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
DT Modulation2	Repaglinide inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Atorvastatin	9 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Atorvastatin inhibits the transportation of Estrone sulfate by SLCO2B1 (IC50 = 0.4 microM)			[16]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Madin Darby canine kidney strain II (MDCKII) cells-OATP2B1
DT Modulation2	Atorvastatin inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
DT Modulation3	glimepiride inhibits the reaction SLCO2B1 protein results in increased uptake of Atorvastatin			[63]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Glyburide inhibits the reaction SLCO2B1 protein results in increased uptake of Atorvastatin			[63]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Nateglinide inhibits the reaction SLCO2B1 protein results in increased uptake of Atorvastatin			[63]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	repaglinide inhibits the reaction SLCO2B1 protein results in increased uptake of Atorvastatin			[63]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	Rosiglitazone inhibits the reaction SLCO2B1 protein results in increased uptake of Atorvastatin			[63]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	SLCO2B1 protein results in increased uptake of Atorvastatin			[63]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	Sulfobromophthalein inhibits the reaction SLCO2B1 protein results in increased uptake of Atorvastatin			[64]
Regulation Mechanism				Transcription Factor Info
Cerivastatin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cerivastatin inhibits the transportation of Estrone sulfate by SLCO2B1 (IC50 = 66.2 microM)			[16]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Madin Darby canine kidney strain II (MDCKII) cells-OATP2B1
DT Modulation2	Cerivastatin inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Simvastatin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Simvastatin inhibits the transportation of Estrone sulfate by SLCO2B1 (IC50 = 84.7 microM)			[16]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Madin Darby canine kidney strain II (MDCKII) cells-OATP2B1
DT Modulation2	Simvastatin inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Indinavir	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Indinavir inhibits the transportation of Estrone sulfate by SLCO2B1 (IC50 = 3.9 microM; Ki = 3 microM)			[3]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human enterocyte-like 2 cell (Caco-2)-OATP2B1
DT Modulation2	Indinavir inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Ritonavir	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ritonavir inhibits the transportation of Estrone sulfate by SLCO2B1 (IC50 = 6.3 microM; Ki = 4.8 microM)			[3]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human enterocyte-like 2 cell (Caco-2)-OATP2B1
DT Modulation2	Ritonavir inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Saquinavir	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Saquinavir inhibits the transportation of Estrone sulfate by SLCO2B1 (IC50 = 5.3 microM; Ki = 4 microM)			[3]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human enterocyte-like 2 cell (Caco-2)-OATP2B1
DT Modulation2	Saquinavir inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Gemfibrozil	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Gemfibrozil inhibits the transportation of Rosuvastatin by SLCO2B1 (IC50 = 8 microM)			[10]
Affected Drug/Substrate	Rosuvastatin	Modulation Type	Inhibition
Cell System	Human cervical cancer cell line (Hela)-OATP2B1
DT Modulation2	Gemfibrozil inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Testosterone	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Testosterone inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
DT Modulation2	Testosterone inhibits the activity of SLCO2B1			[18]
Montelukast	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Montelukast inhibits the transportation of Bromsulphthalein by SLCO2B1 (IC50 = 1 microM)			[9]
Affected Drug/Substrate	Bromsulphthalein	Modulation Type	Inhibition
Cell System	Madin Darby canine kidney strain II (MDCKII) cells-OATP2B1
Estrone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Estrone inhibits the transportation of Estrone sulfate by SLCO2B1 (IC50 = 2.5 microM; Ki = 1.9 microM)			[3]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human enterocyte-like 2 cell (Caco-2)-OATP2B1
Mesalazine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Mesalazine inhibits the transportation of Bromsulphthalein by SLCO2B1			[22]
Affected Drug/Substrate	Bromsulphthalein	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Acarbose	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Acarbose inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Acyclovir	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Acyclovir inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Allopurinol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Allopurinol inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Amantadine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Amantadine inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Amitriptyline	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Amitriptyline inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Amodiaquine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Amodiaquine inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Amprenavir	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Amprenavir inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Atazanavir	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Atazanavir inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Atenolol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Atenolol inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Atomoxetine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Atomoxetine inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Benzbromarone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Benzbromarone inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Bestatin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Bestatin inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Budesonide	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Budesonide inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Bupropion	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Bupropion inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Buspirone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Buspirone inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Caffeine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Caffeine inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Candesartan	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Candesartan inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Captopril	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Captopril inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Carbamazepine	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Carbamazepine inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Cefadroxil	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cefadroxil inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Cefamandole	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cefamandole inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Celecoxib	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Celecoxib inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Cetirizine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cetirizine inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Chloroquine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Chloroquine inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Chlorpromazine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Chlorpromazine inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Chlorprothixene	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Chlorprothixene inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Chlorzoxazone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Chlorzoxazone inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Cholic Acid	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cholic acid inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Cimetidine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cimetidine inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Clarithromycin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Clarithromycin inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Clotrimazole	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Clotrimazole inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Colchicine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Colchicine inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Desipramine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Desipramine inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Dexamethasone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Dexamethasone inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Dextromethorphan	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Dextromethorphan inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Diazepam	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Diazepam inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Diclofenac	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Diclofenac inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Diethylstilbestrol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Diethylstilbestrol inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Digoxin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Digoxin inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Diltiazem	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Diltiazem inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Dipyridamole	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Dipyridamole inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Disopyramide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Disopyramide inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Disulfiram	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Disulfiram inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Dofetilide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Dofetilide inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Doxazosin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Doxazosin inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Doxorubicin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Doxorubicin inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Efavirenz	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Efavirenz inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Eletriptan	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Eletriptan inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Emtricitabine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Emtricitabine inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Enalapril	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Enalapril inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Erlotinib	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Erlotinib inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Erythromycin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Erythromycin inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Etoposide	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Etoposide inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Ezetimibe	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ezetimibe inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Felodipine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Felodipine inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Fenofibrate	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Fenofibrate inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Fentanyl	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Fentanyl inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Fexofenadine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Fexofenadine inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Fluconazole	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Fluconazole inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Fluoxetine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Fluoxetine inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Flutamide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Flutamide inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Fluvastatin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Fluvastatin inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Fluvoxamine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Fluvoxamine inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Furosemide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Furosemide inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Glyburide	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Glibenclamide inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Glipizide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Glipizide inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Ibuprofen	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ibuprofen inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
DT Modulation2	Ibuprofen results in decreased expression of SLCO2B1 mRNA			[36]
Regulation Mechanism				Transcription Factor Info
Imipramine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Imipramine inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Indocyanine green	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Indocyanine green inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Indomethacin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Indomethacin inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Irinotecan	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Irinotecan inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Isoniazid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Isoniazid inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Isradipine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Isradipine inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Ivermectin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ivermectin inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Ketoconazole	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ketoconazole inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Lamotrigine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Lamotrigine inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Lansoprazole	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Lansoprazole inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
L-carnitine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	L-carnitine inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Levofloxacin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Levofloxacin inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Levothyroxine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Levothyroxine inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Lisinopril	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Lisinopril inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Loperamide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Loperamide inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Lopinavir	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Lopinavir inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Loratadine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Loratadine inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Lovastatin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Lovastatin inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Mephenytoin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Mephenytoin inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Metformin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Metformin inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
DT Modulation2	Metformin results in decreased expression of SLCO2B1 mRNA			[36]
Regulation Mechanism				Transcription Factor Info
Methotrexate	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Methotrexate inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Methoxsalen	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Methoxsalen inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Metoprolol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Metoprolol inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Midazolam	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Midazolam inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Mifepristone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Mifepristone inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Mitoxantrone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Mitoxantrone inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Moclobemide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Moclobemide inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Nefazodone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Nefazodone inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Nelfinavir	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Nelfinavir inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Nicardipine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Nicardipine inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Nicotine polacrilex	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Nicotine inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Nifedipine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Nifedipine inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Nitrofurantoin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Nitrofurantoin inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Novobiocin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Novobiocin inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Nystatin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Nystatin inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Olmesartan medoxomil	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Olmesartan medoxomil inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Omeprazole	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Omeprazole inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Ondansetron	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ondansetron inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Ouabain	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ouabain inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Pantoprazole	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Pantoprazole inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Paroxetine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Paroxetine inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Phenobarbital	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Phenobarbital inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Phenylbutazone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Phenylbutazone inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Phenytoin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Phenytoin inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Pilsicainide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Pilsicainide inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Pindolol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Pindolol inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Pioglitazone	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Pioglitazone inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Piroxicam	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Piroxicam inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Pravastatin	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Pravastatin inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Prazosin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Prazosin inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Prednisolone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Prednisolone inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Probenecid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Probenecid inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Procainamide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Procainamide inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Progesterone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Progesterone inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Propranolol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Propranolol inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Quinine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Quinine inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Ranolazine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ranolazine inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Reserpine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Reserpine inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Rosuvastatin Calcium	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Rosuvastatin inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Sanguinarine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sanguinarine inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Sildenafil	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sildenafil inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Sotalol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sotalol inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Spironolactone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Spironolactone inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Sulfaphenazole	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sulfaphenazole inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Sulfasalazine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sulfasalazine inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Tamoxifen	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tamoxifen inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Telmisartan	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Telmisartan inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Tenofovir	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tenofovir inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Tetracycline	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tetracycline inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Theophylline	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Theophylline inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Thioridazine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Thioridazine inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Thiotepa	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Thiotepa inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Ticlopidine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ticlopidine inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Tipranavir	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tipranavir inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Tolbutamide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tolbutamide inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Topotecan	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Topotecan inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Triazolam	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Triazolam inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Trimethoprim	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Trimethoprim inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Valacyclovir	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Valacyclovir inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Valproic Acid	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Valproic Acid inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Valsartan	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Valsartan inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Varenicline	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Varenicline inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Verapamil	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Verapamil inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Vinblastine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Vinblastine inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Vincristine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Vincristine inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Warfarin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Warfarin inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Zidovudine	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Zidovudine inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Estradiol	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Estradiol inhibits the transportation of Estrone sulfate by SLCO2B1			[5], [23]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Benzoic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Benzoic acid inhibits the transportation of Estrone sulfate by SLCO2B1			[24]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Eltrombopag	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Eltrombopag inhibits the transportation of Estrone sulfate by SLCO2B1			[6]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Copper Sulfate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Copper Sulfate inhibits the expression of SLCO2B1			[34]
Hydrogen Peroxide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Hydrogen Peroxide affects the expression of SLCO2B1			[35]
Adefovir dipivoxil	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Adefovir dipivoxil increases the expression of SLCO2B1			[36]
Cidofovir	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cidofovir increases the expression of SLCO2B1			[36]
Rosiglitazone	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Rosiglitazone inhibits the expression of SLCO2B1			[36]
Calcitriol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Calcitriol inhibits the expression of SLCO2B1			[37]
Rifampin	7 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Rifampin increases the expression of SLCO2B1			[38]
Urethane	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Urethane inhibits the expression of SLCO2B1			[39]
Acetaminophen	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Acetaminophen inhibits the expression of SLCO2B1			[40]
Meclizine	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Meclizine increases the expression of SLCO2B1			[41]
Arsenic Trioxide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Arsenic Trioxide increases the expression of SLCO2B1			[42]
Zoledronic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Zoledronic Acid increases the expression of SLCO2B1			[36]
Ergoloid mesylates	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ergoloid mesylates inhibits the activity of SLCO2B1			[43]
Drug in Phase 4 Trial
Berberine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Berberine inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Drug in Phase 2/3 Trial
Silibinin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Silibinin inhibits the transportation of Estrone sulfate by SLCO2B1			[20]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Madin Darby canine kidney strain II (MDCKII) cells-OATP2B1
Drug in Phase 3 Trial
Benzylpenicillin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Benzylpenicillin inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Glycyrrhizic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Glycyrrhizin inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Icariin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Icariin inhibits the activity of SLCO2B1			[46]
Triclosan	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Triclosan increases the expression of SLCO2B1			[51]
Drug in Phase 2 Trial
Genistein	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Genistein inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
PRX-321	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	PRX-321 inhibits the transportation of Estrone sulfate by SLCO2B1			[20]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Madin Darby canine kidney strain II (MDCKII) cells-OATP2B1
Bisphenol A	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Bisphenol A affects the expression of SLCO2B1			[52]
Ethanol	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ethanol increases the expression of SLCO2B1			[41]
Drug in Phase 1/2 Trial
Sodium taurocholate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sodium taurocholate inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
PRI-724	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	PRI-724 markedly inhibits the activity of SLCO2B1			[44]
Cell System	Human embryonic kidney 293 cells (HEK293)-
Drug in Phase 1 Trial
Naringenin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Naringenin inhibits the transportation of Estrone sulfate by SLCO2B1 (IC50 = 49.2 microM)			[4]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Xenopus laevis oocytes-OATP2B1
DT Modulation2	Naringenin inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Sodium arsenite	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sodium arsenite inhibits the expression of SLCO2B1			[50]
Discontinued Drug
MK-571	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	MK-571 inhibits the transportation of Bromsulphthalein by SLCO2B1 (IC50 = 0.2 microM)			[9]
Affected Drug/Substrate	Bromsulphthalein	Modulation Type	Inhibition
Cell System	Madin Darby canine kidney strain II (MDCKII) cells-OATP2B1
DT Modulation2	MK-571 inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Baicalin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Baicalin inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Elacridar	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Elacridar inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Valspodar	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Valspodar inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Investigative Drug
Bromsulphthalein	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Bromsulphthalein inhibits the transportation of Estrone sulfate by SLCO2B1 (IC50 = 1.7 microM)			[2]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Monkey kidney tissue Fibroblast-like cell lines (COS1)-OATP2B1
DT Modulation2	Bromsulphthalein inhibits the transportation of Estrone sulfate by SLCO2B1 (IC50 = 2 microM; Ki = 1.5 microM)			[3]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human enterocyte-like 2 cell (Caco-2)-OATP2B1
DT Modulation3	Bromsulphthalein inhibits the transportation of Estrone sulfate by SLCO2B1			[6]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
DT Modulation4	Bromsulphthalein modulates the activity of SLCO2B1			[7]
Naringin	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Naringin inhibits the transportation of Estrone sulfate by SLCO2B1 (IC50 = 4.63 microM)			[4]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Xenopus laevis oocytes-OATP2B1
DT Modulation2	Naringin inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
DT Modulation3	Naringin inhibits the transportation of Estrone sulfate by SLCO2B1			[11]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Xenopus laevis oocytes-OATP2B1
Kaempferol	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Kaempferol inhibits the transportation of Atorvastatin by SLCO2B1 (IC50 = 20.7 microM; Ki = 15.1 microM)			[1]
Affected Drug/Substrate	Atorvastatin	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
DT Modulation2	Kaempferol inhibits the transportation of Estrone sulfate by SLCO2B1			[17]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Apigenin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Apigenin inhibits the transportation of Atorvastatin by SLCO2B1 (IC50 = 13.9 microM; Ki = 8.7 microM)			[1]
Affected Drug/Substrate	Atorvastatin	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Phloretin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Phloretin inhibits the transportation of Estrone sulfate by SLCO2B1 (IC50 = 1.31 microM)			[4]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Xenopus laevis oocytes-OATP2B1
Aminohippuric acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Aminohippuric acid inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Chelerythrine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Chelerythrine inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Coumarin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Coumarin inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Coumestrol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Coumestrol inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Daidzein	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Daidzein inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Glycochenodeoxycholic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Glycochenodeoxycholic acid inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Glycocholic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Glycocholic acid inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Glycodeoxycholic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Glycodeoxycholic acid inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Morin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Morin inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Phalloidin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Phalloidin inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Sincalide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sincalide inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Taurochenodeoxycholate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Taurochenodeoxycholate inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Tetraethylammonium	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tetraethylammonium inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Estrone sulfate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Estrone sulfate modulates the activity of SLCO2B1			[7]
21H7	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	21H7 inhibits the activity of SLCO2B1			[44]
Cell System	Human embryonic kidney 293 cells (HEK293)-
FH535	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	FH535 inhibits the activity of SLCO2B1			[44]
Cell System	Human embryonic kidney 293 cells (HEK293)-
Drug Withdrawn
Astemizole	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Astemizole inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Fendiline	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Fendiline inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Phenacetin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Phenacetin inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Phenformin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Phenformin inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Terfenadine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Terfenadine inhibits the transportation of Estrone sulfate by SLCO2B1			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Natural Product
DT Modulation1	Cyclosporine inhibits the reaction SLCO2B1 protein results in increased uptake of Quercetin			[71]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	estrone sulfate inhibits the reaction SLCO2B1 protein results in increased uptake of Quercetin			[71]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	SLCO2B1 protein results in increased uptake of Quercetin			[71]
Regulation Mechanism				Transcription Factor Info
Cigarette smoke condensate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cigarette smoke condensate inhibits the transportation of Bromosulfophtalein by by repressing mRNA expression of SLCO2B1 (IC50 = 39.5 microM)			[19]
Affected Drug/Substrate	Bromosulfophtalein	Modulation Type	Inhibition
Cell System	Human hepatoma HepaRG cells-OATP2B1
Silibinin dihemisuccinate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Silibinin dihemisuccinate inhibits the transportation of Bromosulfophthalein by SLCO2B1 (IC50 = 1 microM)			[9]
Affected Drug/Substrate	Bromosulfophthalein	Modulation Type	Inhibition
Cell System	Madin darby canine kidney strain II cell line (MDCKII)-OATP2B1
Silybin A	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Silybin A inhibits the transportation of Estrone sulfate by SLCO2B1 (IC50 = 4.5 microM)			[20]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Silybin B	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Silybin B inhibits the transportation of Estrone sulfate by SLCO2B1 (IC50 = 0.8 microM)			[20]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Silychristin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Silychristin inhibits the transportation of Estrone sulfate by SLCO2B1 (IC50 = 3.6 microM)			[20]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Phlorizin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Phloridzin inhibits the transportation of Estrone sulfate by SLCO2B1 (IC50 = 23.2 microM)			[4]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Xenopus laevis oocytes-OATP2B1
Ginkgo biloba	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ginkgo biloba inhibits the transportation of Estrone sulfate by SLCO2B1 (IC50 = 11.2 +/- 3.3 microM)			[17]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Ginkgo leaf extract	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ginkgo leaf extract inhibits the transportation of Estrone sulfate by SLCO2B1 (IC50 = 11.2 microM)			[17]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Epigallocatechin gallate	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Green tea extract inhibits the transportation of Estrone sulfate by SLCO2B1 (IC50 = 22.1 microM)			[17]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
DT Modulation2	(-)-epigallocatechin-3-gallate inhibits the activity of SLCO2B1 in a substrate-dependent manner (IC50 = 101 microM)			[21]
Cell System	Chinese hamster ovary (CHO) cells-OATP2B1
Epicatechin gallate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	(-)-epicatechin-3-gallate inhibits the activity of SLCO2B1 in a substrate-dependent manner (IC50 = 36 microM)			[21]
Cell System	Chinese hamster ovary (CHO) cells-OATP2B1
Silymarin flavolignans	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Silymarin flavolignans inhibits the transportation of Estrone sulfate by SLCO2B1			[20]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Madin darby canine kidney strain II cell line (MDCKII)-OATP2B1
Herbal extract	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Herbal extracts inhibits the transportation of Estrone sulfate by SLCO2B1			[17]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Bilberry extract	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Bilberry extract inhibits the transportation of Estrone sulfate by SLCO2B1			[17]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Black cohosh extract	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Black cohosh extract inhibits the transportation of Estrone sulfate by SLCO2B1			[17]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Echinacea extract	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Echinacea extract inhibits the transportation of Estrone sulfate by SLCO2B1			[17]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
3-methylquercetin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Isorhamnetin inhibits the transportation of Estrone sulfate by SLCO2B1			[17]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Soybean extract	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Soybean extract inhibits the transportation of Estrone sulfate by SLCO2B1			[17]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP2B1
Bofutsushosan extract	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Bofutsushosan extract inhibits the uptake of estrone sulphate by SLCO2B1			[25]
Affected Drug/Substrate	Estrone Sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)
Glyryrrhizae Radix	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Glyryrrhizae Radix inhibits the uptake of estrone sulphate by SLCO2B1			[25]
Affected Drug/Substrate	Estrone Sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)
Paeoniae Radix	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Paeoniae Radix inhibits the uptake of estrone sulphate by SLCO2B1			[25]
Affected Drug/Substrate	Estrone Sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)
Perillae herba extract	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Perillae herba extract inhibits the uptake of estrone sulphate by SLCO2B1			[25]
Affected Drug/Substrate	Estrone Sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)
Rhei Rhizoma	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Rhei Rhizoma inhibits the uptake of estrone sulphate by SLCO2B1			[25]
Affected Drug/Substrate	Estrone Sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)
Breviscapine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Breviscapine inhibits the uptake of estrone sulphate by SLCO2B1 (IC50 = 2 microM)			[26]
Affected Drug/Substrate	Estrone Sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)
White mulberry	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	White mulberry inhibits the uptake of estrone sulphate by SLCO2B1 (IC50 = 1.8 microM)			[26]
Affected Drug/Substrate	Estrone Sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)
Chinese skullcap	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Chinese skullcap inhibits the uptake of estrone sulphate by SLCO2B1 (IC50 = 5.6 microM)			[27]
Affected Drug/Substrate	Estrone Sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)
Scuterallia Radix	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Scuterallia Radix inhibits the uptake of estrone sulphate by SLCO2B1			[27]
Affected Drug/Substrate	Estrone Sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)
Horny goat weed	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Horny goat weed inhibits the uptake of estrone sulphate by SLCO2B1 (IC50 = 6.4 microM)			[28]
Affected Drug/Substrate	Estrone Sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)
Pomegranat	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Pomegranat inhibits the uptake of estrone sulphate by SLCO2B1 (IC50 = 11 microM)			[29]
Affected Drug/Substrate	Estrone Sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)
Black tea	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Black tea inhibits the uptake of estrone sulphate by SLCO2B1 (Ki = 8.2 microM)			[30]
Affected Drug/Substrate	Estrone Sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)
Green tea	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Green tea inhibits the uptake of estrone sulphate by SLCO2B1 (IC50 = 35.9 microM)			[21]
Affected Drug/Substrate	Estrone Sulfate	Modulation Type	Inhibition
Cell System	Chinese hamster ovary (CHO) cells
Milk thistle	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Milk thistle inhibits the uptake of estrone sulphate by SLCO2B1 (IC50 = 0.3 microM)			[20]
Affected Drug/Substrate	Estrone Sulfate	Modulation Type	Inhibition
Cell System	Madin Darby canine kidney strain II (MDCKII) cells
Moutan cortex	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Moutan cortex inhibits the uptake of estrone sulphate by SLCO2B1			[14]
Affected Drug/Substrate	Estrone Sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)
Allethrin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Allethrin induces the transportation of Fluorescein by SLCO2B1			[31]
Affected Drug/Substrate	Fluorescein	Modulation Type	Inducer
Cell System	Chinese hamster ovary (CHO) cells-OATP2B1
Tetramethrin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tetramethrin induces the transportation of Fluorescein by SLCO2B1			[31]
Affected Drug/Substrate	Fluorescein	Modulation Type	Inducer
Cell System	Chinese hamster ovary (CHO) cells-OATP2B1
Mix silybin A silybin B	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Mix silybin A silybin B inhibits the activity of SLCO2B1			[33]
Cell System	Chinese hamster ovary (CHO) cells-OATP2B1
Particulate Matter	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Particulate Matter inhibits the expression of SLCO2B1			[47]
Heliotrine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Heliotrine inhibits the expression of SLCO2B1			[48]
Tobacco Smoke Pollution	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tobacco Smoke Pollution inhibits the expression of SLCO2B1			[19]
Methyleugenol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Methyleugenol inhibits the expression of SLCO2B1			[54]
Resveratrol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Plant Extracts co-treated with Resveratrol results in decreased expression of SLCO2B1 mRNA			[86]
Regulation Mechanism				Transcription Factor Info
Dietary Constituent
Apple juice	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Apple juice inhibits the transportation of Atenolol by SLCO2B1			[12]
Affected Drug/Substrate	Atenolol	Modulation Type	Inhibition
Cell System	Healthy people
DT Modulation2	Apple juice inhibits the transportation of Estrone sulfate by SLCO2B1			[11]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Xenopus laevis oocytes-OATP2B1
DT Modulation3	Apple juice inhibits the activity of SLCO2B1			[13]
Cell System	Patient samples
DT Modulation4	Apple juice inhibits the uptake of Bromosulphophthalein by SLCO2B1 (Ki = 15.1 microM)			[1]
Affected Drug/Substrate	Bromosulphophthalein	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)
Orange juice	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Orange juice inhibits the transportation of Aliskiren by SLCO2B1 (IC50 = 2.7 microM)			[14]
Affected Drug/Substrate	Aliskiren	Modulation Type	Inhibition
Cell System	Healthy people
DT Modulation2	Orange juice inhibits the transportation of Estrone sulfate by SLCO2B1			[11]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Xenopus laevis oocytes-OATP2B1
Grapefruit juice	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Grapefruit juice inhibits the transportation of Estrone sulfate by SLCO2B1			[11]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Xenopus laevis oocytes-OATP2B1
Citrus juice	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Citrus juice inhibits the transportation of Montelukast by SLCO2B1			[32]
Affected Drug/Substrate	Montelukast	Modulation Type	Inhibition
Environmental toxicant
Polychlorinated dibenzodioxin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Polychlorinated dibenzodioxin inhibits the expression of SLCO2B1			[19]
Mycotoxins
Aflatoxin B1	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Aflatoxin B1 inhibits the expression of SLCO2B1			[55]
DT Modulation2	Aflatoxin B1 affects the expression of SLCO2B1 protein			[60]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Aflatoxin B1 results in increased methylation of SLCO2B1 gene			[55]
Regulation Mechanism				Transcription Factor Info
ochratoxin A	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLCO2B1 protein results in increased uptake of ochratoxin A			[80]
Regulation Mechanism				Transcription Factor Info
Zearalenone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Zearalenone results in decreased activity of SLCO2B1 protein			[93]
Regulation Mechanism				Transcription Factor Info
Acute Toxic Substance
Okadaic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Okadaic Acid inhibits the expression of SLCO2B1			[53]
Carcinogen
Sodium bichromate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sodium bichromate inhibits the expression of SLCO2B1			[45]
Benzo(a)pyrene	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Benzo(a)pyrene inhibits the expression of SLCO2B1			[54]
Arsenic	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLCO2B1 protein results in increased transport of Arsenic			[62]
Regulation Mechanism				Transcription Factor Info
Health and Environmental Toxicant
tris(1,3-dichloro-2-propyl)phosphate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	tris(1,3-dichloro-2-propyl)phosphate inhibits the expression of SLCO2B1			[49]

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40	Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans. Arch Toxicol. 2018 Feb;92(2):845-858.
41	Prenatal ethanol exposure increases maternal bile acids through placental transport pathway. Toxicology. 2021 Jun 30;458:152848.
42	Gene expression profile induced by arsenic trioxide in chronic lymphocytic leukemia cells reveals a central role for heme oxygenase-1 in apoptosis and regulation of matrix metalloproteinase-9. Oncotarget. 2016 Dec 13;7(50):83359-83377.
43	The effects of ergoloid mesylates and ginkgo biloba on the pharmacokinetics of ticlopidine. J Clin Pharmacol. 2006 Jun;46(6):628-34.
44	Impaired Transport Activity of Human Organic Anion Transporters (OATs) and Organic Anion Transporting Polypeptides (OATPs) by Wnt Inhibitors. J Pharm Sci. 2021 Feb;110(2):914-924.
45	Identification of human cell responses to hexavalent chromium. Environ Mol Mutagen. 2007 Oct;48(8):650-7.
46	Interaction of the bioactive flavonol, icariin, with the essential human solute carrier transporters. J Biochem Mol Toxicol. 2014 Feb;28(2):91-7.
47	Regulation of human hepatic drug transporter activity and expression by diesel exhaust particle extract. PLoS One. 2015 Mar 24;10(3):e0121232.
48	Disturbance of gene expression in primary human hepatocytes by hepatotoxic pyrrolizidine alkaloids: A whole genome transcriptome analysis. Toxicol In Vitro. 2015 Oct;29(7):1669-82.
49	Defensive and adverse energy-related molecular responses precede tris (1, 3-dichloro-2-propyl) phosphate cytotoxicity. J Appl Toxicol. 2016 May;36(5):649-58.
50	Cellular and Molecular Effects of Prolonged Low-Level Sodium Arsenite Exposure on Human Hepatic HepaRG Cells. Toxicol Sci. 2018 Apr 1;162(2):676-687.
51	Transcriptome and DNA Methylome Dynamics during Triclosan-Induced Cardiomyocyte Differentiation Toxicity. Stem Cells Int. 2018 Oct 29;2018:8608327.
52	Comprehensive analysis of transcriptomic changes induced by low and high doses of bisphenol A in HepG2 spheroids in vitro and rat liver in vivo. Environ Res. 2019 Jun;173:124-134.
53	Comparison of long-term versus short-term effects of okadaic acid on the apoptotic status of human HepaRG cells. Chem Biol Interact. 2020 Feb 1;317:108937.
54	Identification of a transcriptomic signature of food-relevant genotoxins in human HepaRG hepatocarcinoma cells. Food Chem Toxicol. 2020 Jun;140:111297.
55	Aflatoxin B1 induces persistent epigenomic effects in primary human hepatocytes associated with hepatocellular carcinoma. Toxicology. 2016 Mar 28;350-352:31-9.
56	Mechanism of polybrominated diphenyl ether uptake into the liver: PBDE congeners are substrates of human hepatic OATP transporters. Toxicol Sci. 2010;115(2):344-53.
57	Low risk of the TMPRSS2 inhibitor camostat mesylate and its metabolite GBPA to act as perpetrators of drug-drug interactions. Chem Biol Interact. 2021;338:109428.
58	Fluorescent tagging of endogenous Heme oxygenase-1 in human induced pluripotent stem cells for high content imaging of oxidative stress in various differentiated lineages. Arch Toxicol. 2021;95(10):3285-3302.
59	New insights into BaP-induced toxicity: role of major metabolites in transcriptomics and contribution to hepatocarcinogenesis. Arch Toxicol. 2016 Jun;90(6):1449-58.
60	Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
61	Contribution of organic anion transporting polypeptide OATP2B1 to amiodarone accumulation in lung epithelial cells. Biochim Biophys Acta. 2009;1788(5):911-7.
62	In vitro study of transporters involved in intestinal absorption of inorganic arsenic. Chem Res Toxicol. 2012 Feb 20;25(2):446-53.
63	The influence of oral antidiabetic drugs on cellular drug uptake mediated by hepatic OATP family members. Basic Clin Pharmacol Toxicol. 2013;112(4):244-50.
64	Clinical CYP3A inhibitor alternatives to ketoconazole, clarithromycin and itraconazole, are not transported into the liver by hepatic organic anion transporting polypeptides and organic cation transporter 1. Drug Metab Dispos. 2014;42(11):1780-4.
65	Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017;8(1):1369-1391.
66	Identification of anticancer OATP2B1 substrates by an in vitro triple-fluorescence-based cytotoxicity screen. Arch Toxicol. 2019;93(4):953-964.
67	Transcriptional profiling of genes induced in the livers of patients treated with carbamazepine. Clin Pharmacol Ther. 2006 Nov;80(5):440-456.
68	Identification of potential target genes of ROR-alpha in THP1 and HUVEC cell lines. Exp Cell Res. 2017;353(1):6-15.
69	Quercetin-3-rhamnoglucoside (rutin) stimulates transport of organic anion compounds mediated by organic anion transporting polypeptide 2B1. Biopharm Drug Dispos. 2014;35(3):173-82.
70	The hypoxia-mimetic agent cobalt chloride induces cell cycle arrest and alters gene expression in U266 multiple myeloma cells. Int J Mol Med. 2012;30(5):1180-6.
71	Organic anion transporting polypeptides and organic cation transporter 1 contribute to the cellular uptake of the flavonoid quercetin. Naunyn Schmiedebergs Arch Pharmacol. 2014;387(9):883-91.
72	Evidence for a role of claudin 2 as a proximal tubular stress responsive paracellular water channel. Toxicol Appl Pharmacol. 2014 Sep 1;279(2):163-72.
73	Transport of the soy isoflavone daidzein and its conjugative metabolites by the carriers SOAT, NTCP, OAT4, and OATP2B1. Arch Toxicol. 2015;89(12):2253-63.
74	Roles of breast cancer resistance protein and organic anion transporting polypeptide 2B1 in gastrointestinal toxicity induced by SN-38 under inflammatory conditions. Toxicol Lett. 2024;394:57-65.
75	Expression of Organic Anion Transporting Polypeptide 1A2 in Red Blood Cells and Its Potential Impact on Antimalarial Therapy. Drug Metab Dispos. 2016;44(10):1562-8.
76	Predominant contribution of organic anion transporting polypeptide OATP-B (OATP2B1) to apical uptake of estrone-3-sulfate by human intestinal Caco-2 cells. Drug Metab Dispos. 2006 Aug;34(8):1423-31.
77	Human hepatobiliary transport of organic anions analyzed by quadruple-transfected cells. Mol Pharmacol. 2005 Oct;68(4):1031-8.
78	Downregulation of OATP2B1 by proinflammatory cytokines leads to 5-ASA hyposensitivity in Ulcerative colitis. Chem Biol Interact. 2024;398:111074.
79	Neonicotinoid pesticides poorly interact with human drug transporters. J Biochem Mol Toxicol. 2019 Oct;33(10):e22379.
80	Ochratoxin A transport by the human breast cancer resistance protein (BCRP), multidrug resistance protein 2 (MRP2), and organic anion-transporting polypeptides 1A2, 1B1 and 2B1. Toxicol Appl Pharmacol. 2017;329:18-25.
81	Organic Anion Transporting Polypeptides Contribute to the Disposition of Perfluoroalkyl Acids in Humans and Rats. Toxicol Sci. 2017;156(1):84-95.
82	Perfluorooctanoic acid (PFOA), perfluorooctane sulfonic acid (PFOS), and perfluorononanoic acid (PFNA) increase triglyceride levels and decrease cholesterogenic gene expression in human HepaRG liver cells. Arch Toxicol. 2020 Sep;94(9):3137-3155.
83	Reproducible chemical-induced changes in gene expression profiles in human hepatoma HepaRG cells under various experimental conditions. Toxicol In Vitro. 2009 Apr;23(3):466-75.
84	Differential regulation of sinusoidal and canalicular hepatic drug transporter expression by xenobiotics activating drug-sensing receptors in primary human hepatocytes. Drug Metab Dispos. 2006 Oct;34(10):1756-63.
85	Proteomic analysis of hepatic effects of phenobarbital in mice with humanized liver. Arch Toxicol. 2022 Oct;96(10):2739-2754.
86	One-year supplementation with a grape extract containing resveratrol modulates inflammatory-related microRNAs and cytokines expression in peripheral blood mononuclear cells of type 2 diabetes and hypertensive patients with coronary artery disease. Pharmacol Res. 2013;72:69-82.
87	The trichloroethylene metabolite S-(1,2-dichlorovinyl)-l-cysteine inhibits lipopolysaccharide-induced inflammation transcriptomic pathways and cytokine secretion in a macrophage cell model. Toxicol In Vitro. 2022;84:105429.
88	Microarray dataset of transient and permanent DNA methylation changes in HeLa cells undergoing inorganic arsenic-mediated epithelial-to-mesenchymal transition. Data Brief. 2017;13:6-9.
89	The NRF2-KEAP1 pathway is an early responsive gene network in arsenic exposed lymphoblastoid cells. PLoS One. 2014;9(2):e88069.
90	Theaflavin 3, 3'-Digallate Delays Ovarian Aging by Improving Oocyte Quality and Regulating Granulosa Cell Function. Oxid Med Cell Longev. 2021;2021:7064179.
91	Gene Expression Regulation and Pathway Analysis After Valproic Acid and Carbamazepine Exposure in a Human Embryonic Stem Cell-Based Neurodevelopmental Toxicity Assay. Toxicol Sci. 2015 Aug;146(2):311-20.
92	Endothelial effects of emission source particles: acute toxic response gene expression profiles. Toxicol In Vitro. 2009 Feb;23(1):67-77.
93	Interaction of mycotoxins zearalenone, zearalenol, and zearalenol with cytochrome P450 (CYP1A2, 2C9, 2C19, 2D6, and 3A4) enzymes and organic anion transporting polypeptides (OATP1A2, OATP1B1, OATP1B3, and OATP2B1). Toxicol In Vitro. 2024;96:105789.
94	Differential gene expression in human hepatocyte cell lines exposed to the antiretroviral agent zidovudine. Arch Toxicol. 2014 Mar;88(3):609-23.

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