Detail Information of Exogenous Modulation

General Information of Drug Transporter (DT)
DT ID	DTD0030 Transporter Info
Gene Name	SLCO1B3
Transporter Name	Organic anion transporting polypeptide 1B3
Gene ID	28234
UniProt ID	Q9NPD5

Exogenous factors (drugs, dietary constituents, etc.) Modulation of This DT (EGM)
Chemical Compound
DT Modulation1	Cyclosporine inhibits the reaction SLCO1B3 protein results in increased import of cyanoginosin LR			[79]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Cyclosporine inhibits the reaction SLCO1B3 protein results in increased uptake of fexofenadine			[84]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Cyclosporine inhibits the reaction SLCO1B3 protein results in increased uptake of fluorescein-methotrexate			[85]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Cyclosporine inhibits the reaction SLCO1B3 protein results in increased uptake of Mesalamine			[29]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Cyclosporine inhibits the reaction SLCO1B3 protein results in increased uptake of Sulfobromophthalein			[29]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Cyclosporine results in increased expression of SLCO1B3 mRNA			[86]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	icariin results in decreased activity of SLCO1B3 protein which results in decreased uptake of Sincalide			[48]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	SLCO1B3 protein affects the import of Sincalide			[89]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	SLCO1B3 protein affects the uptake of Sincalide			[101]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Ritonavir results in decreased activity of SLCO1B3 protein			[62]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Probenecid inhibits the reaction SLCO1B3 protein results in increased uptake of Fluorescein			[54]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Tamoxifen results in decreased activity of SLCO1B3 protein			[62]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Lithocholic Acid results in increased expression of SLCO1B3 mRNA			[35]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	SLCO1B3 protein results in increased transport of Lithocholic Acid			[76]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	SLCO1B3 protein results in increased transport of Lithocholic Acid which results in increased expression of PTGS2 mRNA			[76]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	SLCO1B3 protein results in increased uptake of Lithocholic Acid			[77]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Budesonide inhibits the reaction SLCO1B3 protein results in increased uptake of Mesalamine			[29]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Budesonide inhibits the reaction SLCO1B3 protein results in increased uptake of Sulfobromophthalein			[29]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Carbamazepine results in increased expression of SLCO1B3 mRNA			[74]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Celecoxib results in decreased activity of SLCO1B3 protein			[62]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Cholic Acid results in increased expression of SLCO1B3 mRNA			[35]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	SLCO1B3 protein results in increased uptake of Cholic Acid			[77]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Clarithromycin inhibits the reaction SLCO1B3 protein results in increased uptake of Sulfobromophthalein			[29]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Erythromycin results in decreased activity of SLCO1B3 protein			[62]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Fluoxetine results in decreased activity of SLCO1B3 protein			[62]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	SLCO1B3 protein affects the import of Fluvastatin			[89]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Glyburide inhibits the reaction SLCO1B3 protein results in increased uptake of Atorvastatin			[69]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Imipramine results in decreased activity of SLCO1B3 protein			[62]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Levofloxacin results in decreased activity of SLCO1B3 protein			[62]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Phenobarbital results in decreased expression of SLCO1B3 mRNA			[47]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Pioglitazone affects the reaction SLCO1B3 protein results in increased uptake of Sulfobromophthalein			[69]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Pioglitazone results in decreased activity of SLCO1B3 protein			[62]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Pravastatin inhibits the reaction SLCO1B3 protein results in increased uptake of Mesalamine			[29]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Pravastatin inhibits the reaction SLCO1B3 protein results in increased uptake of Sulfobromophthalein			[29]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Fusidic Acid inhibits the reaction SLCO1B3 protein results in increased uptake of Rosuvastatin Calcium			[90]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	SLCO1B3 protein results in increased uptake of Rosuvastatin Calcium			[90]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Theophylline results in decreased activity of SLCO1B3 protein			[62]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Ticlopidine results in decreased activity of SLCO1B3 protein			[62]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Valproic Acid results in decreased activity of SLCO1B3 protein			[62]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Valproic Acid results in decreased expression of SLCO1B3 mRNA			[106]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Valsartan results in decreased activity of SLCO1B3 protein			[62]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	SLCO1B3 gene SNP affects the susceptibility to Warfarin			[107]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Rifampin inhibits the reaction SLCO1B3 protein results in increased import of cyanoginosin LR			[79]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Rifampin inhibits the reaction SLCO1B3 protein results in increased susceptibility to Docetaxel			[73]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Rifampin inhibits the reaction SLCO1B3 protein results in increased uptake of epyrifenacil metabolite			[87]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Rifampin inhibits the reaction SLCO1B3 protein results in increased uptake of estradiol-17 beta-glucuronide			[83]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Rifampin inhibits the reaction SLCO1B3 protein results in increased uptake of fexofenadine			[84]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Rifampin inhibits the reaction SLCO1B3 protein results in increased uptake of Hydroxyurea			[92]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	Rifampin inhibits the reaction SLCO1B3 protein results in increased uptake of Mesalamine			[29]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	Rifampin inhibits the reaction SLCO1B3 protein results in increased uptake of Sulfobromophthalein			[29]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	Rifampin inhibits the reaction SLCO1B3 protein results in increased uptake of Ursodeoxycholic Acid metabolite			[98]
Regulation Mechanism				Transcription Factor Info
DT Modulation10	Rifampin results in decreased activity of SLCO1B3 protein			[99]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Cisplatin co-treated with jinfukang results in decreased expression of SLCO1B3 mRNA			[37]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	darolutamide affects the reaction SLCO1B3 protein results in increased import of Docetaxel			[73]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	darolutamide metabolite affects the reaction SLCO1B3 protein results in increased import of Docetaxel			[73]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Rifampin inhibits the reaction SLCO1B3 protein results in increased susceptibility to Docetaxel			[73]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	SLCO1B3 protein results in increased import of Docetaxel			[73]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	SLCO1B3 protein results in increased susceptibility to Docetaxel			[73]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Fusidic Acid inhibits the reaction SLCO1B3 protein results in increased uptake of Rosuvastatin Calcium			[90]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Fusidic Acid results in decreased activity of SLCO1B3 protein			[53]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	TAK-875 inhibits the reaction SLCO1B3 protein results in increased transport of Bile Acids and Salts			[103]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	TAK-875 metabolite results in decreased activity of SLCO1B3 protein			[55]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	TAK-875 results in decreased activity of SLCO1B3 protein			[103]
Regulation Mechanism				Transcription Factor Info
2,2',4,4',5,6'-hexabromodiphenyl ether	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	2,2',4,4',5,6'-hexabromodiphenyl ether inhibits the reaction SLCO1B3 results in increased import of estradiol-17 beta-glucuronide			[60]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	SLCO1B3 results in increased import of 2,2',4,4',5,6'-hexabromodiphenyl ether			[60]
Regulation Mechanism				Transcription Factor Info
2,2',4,4'-tetrabromodiphenyl ether	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	2,2',4,4'-tetrabromodiphenyl ether inhibits the reaction SLCO1B3 results in increased import of estradiol-17 beta-glucuronide			[60]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	SLCO1B3 results in increased import of 2,2',4,4'-tetrabromodiphenyl ether			[60]
Regulation Mechanism				Transcription Factor Info
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLCO1B3 protein results in increased uptake of 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one			[61]
Regulation Mechanism				Transcription Factor Info
akebia saponin D	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	akebia saponin D results in decreased activity of SLCO1B3 protein			[65]
Regulation Mechanism				Transcription Factor Info
Alpha-Amanitin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLCO1B3 protein results in increased uptake of and results in increased abundance of Alpha-Amanitin			[66]
Regulation Mechanism				Transcription Factor Info
Apigenin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Apigenin inhibits the reaction SLCO1B3 protein results in increased import of Sulfobromophthalein			[67]
Regulation Mechanism				Transcription Factor Info
Benzo(a)pyrene	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Benzo(a)pyrene results in decreased methylation of SLCO1B3 5' UTR			[71]
Regulation Mechanism				Transcription Factor Info
bisphenol A	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	bisphenol A inhibits the reaction SLCO1B3 protein results in increased uptake of Fluorescein			[54]
Regulation Mechanism				Transcription Factor Info
bisphenol F	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	bisphenol F promotes the reaction SLCO1B3 protein results in increased uptake of Fluorescein			[54]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	bisphenol F results in decreased methylation of SLCO1B3 gene			[72]
Regulation Mechanism				Transcription Factor Info
cabazitaxel	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLCO1B3 protein results in increased import of cabazitaxel			[73]
Regulation Mechanism				Transcription Factor Info
cauloside A	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	cauloside A results in decreased activity of SLCO1B3 protein			[65]
Regulation Mechanism				Transcription Factor Info
CGP 52608	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	CGP 52608 promotes the reaction RORA protein binds to SLCO1B3 gene			[75]
Regulation Mechanism				Transcription Factor Info
Chenodeoxycholic Acid	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Chenodeoxycholic Acid results in increased expression of SLCO1B3 mRNA			[35]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Acetaminophen results in decreased expression of SLCO1B3 mRNA			[63]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	SLCO1B3 protein results in increased transport of Chenodeoxycholic Acid			[76]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	SLCO1B3 protein results in increased transport of Chenodeoxycholic Acid which results in increased expression of PTGS2 mRNA			[76]
Regulation Mechanism				Transcription Factor Info
chikusetsu saponin IVa	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	chikusetsu saponin IVa results in decreased activity of SLCO1B3 protein			[65]
Regulation Mechanism				Transcription Factor Info
Clopidogrel	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Clopidogrel results in decreased activity of SLCO1B3 protein			[62]
Regulation Mechanism				Transcription Factor Info
Clozapine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Clozapine results in decreased activity of SLCO1B3 protein			[62]
Regulation Mechanism				Transcription Factor Info
cobaltous chloride	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	cobaltous chloride results in decreased expression of SLCO1B3 mRNA			[78]
Regulation Mechanism				Transcription Factor Info
cyazofamid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	cyazofamid inhibits the reaction SLCO1B3 protein results in increased uptake of estrone sulfate			[83]
Regulation Mechanism				Transcription Factor Info
darolutamide	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	darolutamide affects the reaction SLCO1B3 protein results in increased import of Docetaxel			[73]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	darolutamide inhibits the reaction SLCO1B3 protein results in increased import of estradiol-17 beta-glucuronide			[73]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	darolutamide metabolite affects the reaction SLCO1B3 protein results in increased import of Docetaxel			[73]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	darolutamide metabolite inhibits the reaction SLCO1B3 protein results in increased import of estradiol-17 beta-glucuronide			[73]
Regulation Mechanism				Transcription Factor Info
Dehydroepiandrosterone Sulfate	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Dehydroepiandrosterone Sulfate inhibits the reaction SLCO1B3 protein results in increased susceptibility to cyanoginosin LR			[80]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Dehydroepiandrosterone Sulfate inhibits the reaction SLCO1B3 protein results in increased susceptibility to Okadaic Acid			[80]
Regulation Mechanism				Transcription Factor Info
Deoxycholic Acid	5 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Deoxycholic Acid results in increased expression of SLCO1B3 mRNA			[35]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Acetaminophen results in decreased expression of SLCO1B3 mRNA			[63]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	SLCO1B3 protein results in increased transport of Deoxycholic Acid			[76]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	SLCO1B3 protein results in increased transport of Deoxycholic Acid which results in increased expression of PTGS2 mRNA			[76]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	SLCO1B3 protein results in increased uptake of Deoxycholic Acid			[77]
Regulation Mechanism				Transcription Factor Info
Donepezil	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Donepezil results in decreased activity of SLCO1B3 protein			[62]
Regulation Mechanism				Transcription Factor Info
echinocystic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	echinocystic acid results in decreased activity of SLCO1B3 protein			[65]
Regulation Mechanism				Transcription Factor Info
ecliptasaponin A	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ecliptasaponin A results in decreased activity of SLCO1B3 protein			[65]
Regulation Mechanism				Transcription Factor Info
epyrifenacil	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Rifampin inhibits the reaction SLCO1B3 protein results in increased uptake of epyrifenacil metabolite			[87]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	rifamycin SV inhibits the reaction SLCO1B3 protein results in increased uptake of epyrifenacil metabolite			[87]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	SLCO1B3 protein results in increased uptake of epyrifenacil metabolite			[87]
Regulation Mechanism				Transcription Factor Info
estrone sulfate	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	cyazofamid inhibits the reaction SLCO1B3 protein results in increased uptake of estrone sulfate			[83]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	SLCO1B3 protein results in increased uptake of estrone sulfate			[87]
Regulation Mechanism				Transcription Factor Info
Ethinyl Estradiol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ethinyl Estradiol results in decreased activity of SLCO1B3 protein			[62]
Regulation Mechanism				Transcription Factor Info
fexofenadine	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cyclosporine inhibits the reaction SLCO1B3 protein results in increased uptake of fexofenadine			[84]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Rifampin inhibits the reaction SLCO1B3 protein results in increased uptake of fexofenadine			[84]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	SLCO1B3 protein co-treated with ABCC2 protein results in increased uptake of fexofenadine			[84]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	SLCO1B3 protein results in increased uptake of fexofenadine			[88]
Regulation Mechanism				Transcription Factor Info
Fluorescein	5 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	bisphenol A inhibits the reaction SLCO1B3 protein results in increased uptake of Fluorescein			[54]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	bisphenol F promotes the reaction SLCO1B3 protein results in increased uptake of Fluorescein			[54]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Probenecid inhibits the reaction SLCO1B3 protein results in increased uptake of Fluorescein			[54]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	SLCO1B3 protein results in increased uptake of Fluorescein			[54]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	tetrabromobisphenol A inhibits the reaction SLCO1B3 protein results in increased uptake of Fluorescein			[54]
Regulation Mechanism				Transcription Factor Info
fluorescein-methotrexate	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cyclosporine inhibits the reaction SLCO1B3 protein results in increased uptake of fluorescein-methotrexate			[85]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	SLCO1B3 protein results in increased uptake of fluorescein-methotrexate			[85]
Regulation Mechanism				Transcription Factor Info
ginsenoside Rb1	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ginsenoside Rb1 binds to and results in decreased activity of SLCO1B3 protein			[91]
Regulation Mechanism				Transcription Factor Info
ginsenoside Rc	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ginsenoside Rc binds to and results in decreased activity of SLCO1B3 protein			[91]
Regulation Mechanism				Transcription Factor Info
ginsenoside Rd	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ginsenoside Rd binds to and results in decreased activity of SLCO1B3 protein			[91]
Regulation Mechanism				Transcription Factor Info
ginsenoside Re	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLCO1B3 protein binds to and results in increased transport of ginsenoside Re			[91]
Regulation Mechanism				Transcription Factor Info
ginsenoside Rg1	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLCO1B3 protein binds to and results in increased transport of ginsenoside Rg1			[91]
Regulation Mechanism				Transcription Factor Info
glimepiride	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	glimepiride affects the reaction SLCO1B3 protein results in increased uptake of Atorvastatin			[69]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	glimepiride affects the reaction SLCO1B3 protein results in increased uptake of Sulfobromophthalein			[69]
Regulation Mechanism				Transcription Factor Info
Glycochenodeoxycholic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Acetaminophen results in decreased expression of SLCO1B3 mRNA			[63]
Regulation Mechanism				Transcription Factor Info
Glycocholic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Acetaminophen results in decreased expression of SLCO1B3 mRNA			[63]
Regulation Mechanism				Transcription Factor Info
Glycodeoxycholic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Acetaminophen results in decreased expression of SLCO1B3 mRNA			[63]
Regulation Mechanism				Transcription Factor Info
Hydroxyurea	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	naringin inhibits the reaction SLCO1B3 protein results in increased uptake of Hydroxyurea			[92]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Rifampin inhibits the reaction SLCO1B3 protein results in increased uptake of Hydroxyurea			[92]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	SLCO1B3 protein results in increased uptake of Hydroxyurea			[92]
Regulation Mechanism				Transcription Factor Info
icariin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	icariin results in decreased activity of SLCO1B3 protein			[48]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	icariin results in decreased activity of SLCO1B3 protein which results in decreased uptake of Sincalide			[48]
Regulation Mechanism				Transcription Factor Info
Indican	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Indican results in decreased expression of SLCO1B3 mRNA			[93]
Regulation Mechanism				Transcription Factor Info
kaempferol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	kaempferol inhibits the reaction SLCO1B3 protein results in increased import of Sulfobromophthalein			[67]
Regulation Mechanism				Transcription Factor Info
Mesalamine	5 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Budesonide inhibits the reaction SLCO1B3 protein results in increased uptake of Mesalamine			[29]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Cyclosporine inhibits the reaction SLCO1B3 protein results in increased uptake of Mesalamine			[29]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Pravastatin inhibits the reaction SLCO1B3 protein results in increased uptake of Mesalamine			[29]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Rifampin inhibits the reaction SLCO1B3 protein results in increased uptake of Mesalamine			[29]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	SLCO1B3 protein results in increased uptake of Mesalamine			[29]
Regulation Mechanism				Transcription Factor Info
naringenin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	naringenin inhibits the reaction SLCO1B3 protein results in increased import of Sulfobromophthalein			[67]
Regulation Mechanism				Transcription Factor Info
naringin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	naringin inhibits the reaction SLCO1B3 protein results in increased import of Sulfobromophthalein			[67]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	naringin inhibits the reaction SLCO1B3 protein results in increased uptake of Hydroxyurea			[92]
Regulation Mechanism				Transcription Factor Info
Nateglinide	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Nateglinide inhibits the reaction SLCO1B3 protein results in increased uptake of Atorvastatin			[69]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Nateglinide inhibits the reaction SLCO1B3 protein results in increased uptake of Sulfobromophthalein			[69]
Regulation Mechanism				Transcription Factor Info
notoginsenoside R1	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLCO1B3 protein binds to and results in increased transport of notoginsenoside R1			[91]
Regulation Mechanism				Transcription Factor Info
obeticholic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	obeticholic acid results in increased expression of SLCO1B3 mRNA			[38]
Regulation Mechanism				Transcription Factor Info
Okadaic Acid	5 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Dehydroepiandrosterone Sulfate inhibits the reaction SLCO1B3 protein results in increased susceptibility to Okadaic Acid			[80]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Okadaic Acid inhibits the reaction SLCO1B3 protein results in increased uptake of cyanoginosin LR			[80]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	SLCO1B3 protein results in increased susceptibility to Okadaic Acid			[80]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Sulfobromophthalein inhibits the reaction SLCO1B3 protein results in increased susceptibility to Okadaic Acid			[80]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Taurocholic Acid inhibits the reaction SLCO1B3 protein results in increased susceptibility to Okadaic Acid			[80]
Regulation Mechanism				Transcription Factor Info
olmesartan	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	olmesartan results in decreased activity of SLCO1B3 protein			[62]
Regulation Mechanism				Transcription Factor Info
oltipraz	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	oltipraz results in decreased expression of SLCO1B3 mRNA			[47]
Regulation Mechanism				Transcription Factor Info
pentabromodiphenyl ether	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	pentabromodiphenyl ether inhibits the reaction SLCO1B3 results in increased import of estradiol-17 beta-glucuronide			[60]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	SLCO1B3 results in increased import of pentabromodiphenyl ether			[60]
Regulation Mechanism				Transcription Factor Info
perfluorobutanesulfonic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLCO1B3 protein results in increased transport of perfluorobutanesulfonic acid			[95]
Regulation Mechanism				Transcription Factor Info
perfluorohexanesulfonic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLCO1B3 protein results in increased transport of perfluorohexanesulfonic acid			[95]
Regulation Mechanism				Transcription Factor Info
perfluorooctane sulfonic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLCO1B3 protein results in increased transport of perfluorooctane sulfonic acid			[95]
Regulation Mechanism				Transcription Factor Info
Phalloidine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLCO1B3 protein results in increased uptake of Phalloidine			[96]
Regulation Mechanism				Transcription Factor Info
Primidone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Primidone results in decreased activity of SLCO1B3 protein			[62]
Regulation Mechanism				Transcription Factor Info
repaglinide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	repaglinide inhibits the reaction SLCO1B3 protein results in increased uptake of Atorvastatin			[69]
Regulation Mechanism				Transcription Factor Info
rifamycin SV	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	rifamycin SV inhibits the reaction SLCO1B3 protein results in increased import of 8-sulfocholecystokinin octapeptide			[16]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	rifamycin SV inhibits the reaction SLCO1B3 protein results in increased uptake of epyrifenacil metabolite			[87]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	rifamycin SV results in decreased activity of SLCO1B3 protein			[100]
Regulation Mechanism				Transcription Factor Info
Rosiglitazone	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Rosiglitazone inhibits the reaction SLCO1B3 protein results in increased uptake of Atorvastatin			[69]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Rosiglitazone results in decreased activity of SLCO1B3 protein			[62]
Regulation Mechanism				Transcription Factor Info
Rutin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Rutin inhibits the reaction SLCO1B3 protein results in increased import of Sulfobromophthalein			[67]
Regulation Mechanism				Transcription Factor Info
saikosaponin D	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	saikosaponin D results in decreased activity of SLCO1B3 protein			[65]
Regulation Mechanism				Transcription Factor Info
senecionine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	senecionine results in decreased expression of SLCO1B3 mRNA			[50]
Regulation Mechanism				Transcription Factor Info
Sulfobromophthalein	24 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Apigenin inhibits the reaction SLCO1B3 protein results in increased import of Sulfobromophthalein			[67]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Budesonide inhibits the reaction SLCO1B3 protein results in increased uptake of Sulfobromophthalein			[29]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Clarithromycin inhibits the reaction SLCO1B3 protein results in increased uptake of Sulfobromophthalein			[29]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Cyclosporine inhibits the reaction SLCO1B3 protein results in increased uptake of Sulfobromophthalein			[29]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	glimepiride affects the reaction SLCO1B3 protein results in increased uptake of Sulfobromophthalein			[69]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	kaempferol inhibits the reaction SLCO1B3 protein results in increased import of Sulfobromophthalein			[67]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	naringenin inhibits the reaction SLCO1B3 protein results in increased import of Sulfobromophthalein			[67]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	naringin inhibits the reaction SLCO1B3 protein results in increased import of Sulfobromophthalein			[67]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	Nateglinide inhibits the reaction SLCO1B3 protein results in increased uptake of Sulfobromophthalein			[69]
Regulation Mechanism				Transcription Factor Info
DT Modulation10	Pioglitazone affects the reaction SLCO1B3 protein results in increased uptake of Sulfobromophthalein			[69]
Regulation Mechanism				Transcription Factor Info
DT Modulation11	Pravastatin inhibits the reaction SLCO1B3 protein results in increased uptake of Sulfobromophthalein			[29]
Regulation Mechanism				Transcription Factor Info
DT Modulation12	Quercetin inhibits the reaction SLCO1B3 protein results in increased import of Sulfobromophthalein			[67]
Regulation Mechanism				Transcription Factor Info
DT Modulation13	Rifampin inhibits the reaction SLCO1B3 protein results in increased uptake of Sulfobromophthalein			[29]
Regulation Mechanism				Transcription Factor Info
DT Modulation14	Rutin inhibits the reaction SLCO1B3 protein results in increased import of Sulfobromophthalein			[67]
Regulation Mechanism				Transcription Factor Info
DT Modulation15	SLCO1B3 protein affects the import of Sulfobromophthalein			[89]
Regulation Mechanism				Transcription Factor Info
DT Modulation16	SLCO1B3 protein results in increased import of Sulfobromophthalein			[67]
Regulation Mechanism				Transcription Factor Info
DT Modulation17	SLCO1B3 protein results in increased susceptibility to Sulfobromophthalein			[82]
Regulation Mechanism				Transcription Factor Info
DT Modulation18	SLCO1B3 protein results in increased uptake of Sulfobromophthalein			[29]
Regulation Mechanism				Transcription Factor Info
DT Modulation19	Sulfobromophthalein inhibits the reaction SLCO1B3 protein results in increased import of cyanoginosin LR			[79]
Regulation Mechanism				Transcription Factor Info
DT Modulation20	Sulfobromophthalein inhibits the reaction SLCO1B3 protein results in increased susceptibility to cyanoginosin LR			[82]
Regulation Mechanism				Transcription Factor Info
DT Modulation21	Sulfobromophthalein inhibits the reaction SLCO1B3 protein results in increased susceptibility to Okadaic Acid			[80]
Regulation Mechanism				Transcription Factor Info
DT Modulation22	Sulfobromophthalein inhibits the reaction SLCO1B3 protein results in increased uptake of (5-(3-(4-(2-bromo-5-fluorophenoxy)piperidin-1-yl)isoxazol-5-yl)-2H-tetrazol-2-yl)acetic acid			[102]
Regulation Mechanism				Transcription Factor Info
DT Modulation23	Sulfobromophthalein inhibits the reaction SLCO1B3 protein results in increased uptake of Atorvastatin			[70]
Regulation Mechanism				Transcription Factor Info
DT Modulation24	Sulfobromophthalein inhibits the reaction SLCO1B3 protein results in increased uptake of CCK protein modified form			[70]
Regulation Mechanism				Transcription Factor Info
Taurocholic Acid	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLCO1B3 protein results in increased uptake of Taurocholic Acid			[96]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Taurocholic Acid inhibits the reaction SLCO1B3 protein results in increased susceptibility to cyanoginosin LR			[80]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Taurocholic Acid inhibits the reaction SLCO1B3 protein results in increased susceptibility to Okadaic Acid			[80]
Regulation Mechanism				Transcription Factor Info
tetrabromobisphenol A	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	tetrabromobisphenol A inhibits the reaction SLCO1B3 protein results in increased uptake of Fluorescein			[54]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	tetrabromobisphenol A results in decreased activity of SLCO1B3 protein			[54]
Regulation Mechanism				Transcription Factor Info
Tetrachlorodibenzodioxin	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tetrachlorodibenzodioxin affects the expression of SLCO1B3 mRNA			[104]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Tetrachlorodibenzodioxin co-treated with 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide results in increased expression of SLCO1B3 mRNA			[57]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Tetrachlorodibenzodioxin results in decreased expression of SLCO1B3 mRNA			[47]
Regulation Mechanism				Transcription Factor Info
trospium chloride	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	trospium chloride results in decreased activity of SLCO1B3 protein			[105]
Regulation Mechanism				Transcription Factor Info
Ursodeoxycholic Acid	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Rifampin inhibits the reaction SLCO1B3 protein results in increased uptake of Ursodeoxycholic Acid metabolite			[98]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	SLCO1B3 protein results in increased uptake of Ursodeoxycholic Acid			[77]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	SLCO1B3 protein results in increased uptake of Ursodeoxycholic Acid metabolite			[98]
Regulation Mechanism				Transcription Factor Info
zafirlukast	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	zafirlukast results in decreased activity of SLCO1B3 protein			[62]
Regulation Mechanism				Transcription Factor Info
zearalenol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	zearalenol results in decreased activity of SLCO1B3 protein			[108]
Regulation Mechanism				Transcription Factor Info
Carcinogen
Arsenic	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Arsenic affects the methylation of SLCO1B3 gene			[68]
Regulation Mechanism				Transcription Factor Info
Cyanotoxin
cyanoginosin LR	10 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cyclosporine inhibits the reaction SLCO1B3 protein results in increased import of cyanoginosin LR			[79]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Dehydroepiandrosterone Sulfate inhibits the reaction SLCO1B3 protein results in increased susceptibility to cyanoginosin LR			[80]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Okadaic Acid inhibits the reaction SLCO1B3 protein results in increased uptake of cyanoginosin LR			[80]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Rifampin inhibits the reaction SLCO1B3 protein results in increased import of cyanoginosin LR			[79]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	SLCO1B3 protein results in increased import of cyanoginosin LR			[79]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	SLCO1B3 protein results in increased susceptibility to cyanoginosin LR			[79]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	SLCO1B3 protein results in increased uptake of cyanoginosin LR			[81]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	Sulfobromophthalein inhibits the reaction SLCO1B3 protein results in increased import of cyanoginosin LR			[79]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	Sulfobromophthalein inhibits the reaction SLCO1B3 protein results in increased susceptibility to cyanoginosin LR			[82]
Regulation Mechanism				Transcription Factor Info
DT Modulation10	Taurocholic Acid inhibits the reaction SLCO1B3 protein results in increased susceptibility to cyanoginosin LR			[80]
Regulation Mechanism				Transcription Factor Info
microcystin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLCO1B3 protein results in increased susceptibility to microcystin analog			[82]
Regulation Mechanism				Transcription Factor Info
microcystin-LF	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLCO1B3 protein results in increased susceptibility to microcystin-LF			[82]
Regulation Mechanism				Transcription Factor Info
Approved Drug
Rifampicin	9 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Rifampicin inhibits the transportation of Amantinin by SLCO1B3 (IC50 = 0.8 microM)			[1]
Affected Drug/Substrate	Amantinin	Modulation Type	Inhibition
Cell System	Madin Darby canine kidney strain II (MDCKII) cells-OATP1B3
DT Modulation2	Rifampicin inhibits the transportation of Bosentan by SLCO1B3 (IC50 = 1.6 microM)			[2]
Affected Drug/Substrate	Bosentan	Modulation Type	Inhibition
Cell System	Chinese hamster ovary (CHO) cells-OATP1B1
DT Modulation3	Rifampicin inhibits the transportation of Bromsulphthalein by SLCO1B3 (IC50 = 1.5 microM)			[1]
Affected Drug/Substrate	Bromsulphthalein	Modulation Type	Inhibition
Cell System	Madin Darby canine kidney strain II (MDCKII) cells-OATP1B3
DT Modulation4	Rifampicin inhibits the transportation of Cholyl-glycylamido-fluorescein by SLCO1B3 (IC50 = 1.3 microM; Ki = 0.9 microM)			[3]
Affected Drug/Substrate	Cholyl-glycylamido-fluorescein	Modulation Type	Inhibition
Cell System	Chinese hamster ovary (CHO) cells-OATP1B3
DT Modulation5	Rifampicin inhibits the transportation of Estradiol-17beta-glucuronide by SLCO1B3 (IC50 = 2.6 microM)			[4]
Affected Drug/Substrate	Estradiol-17beta-glucuronide	Modulation Type	Inhibition
Cell System	Chinese hamster ovary (CHO) cells-OATP1B3
DT Modulation6	Rifampicin inhibits the transportation of Sulfobromophthalein by SLCO1B3 (Ki = 5 microM)			[5]
Affected Drug/Substrate	Sulfobromophthalein	Modulation Type	Inhibition
Cell System	Oocytes-OATP1B3
DT Modulation7	Rifampicin inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
DT Modulation8	Rifampicin inhibits the transportation of Sincalide by SLCO1B3			[7]
Affected Drug/Substrate	Sincalide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
DT Modulation9	Rifampicin inhibits the activity of SLCO1B3			[5], [8]
Paclitaxel	7 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Paclitaxel inhibits the transportation of Amantinin by SLCO1B3 (IC50 = 2 microM)			[1]
Affected Drug/Substrate	Amantinin	Modulation Type	Inhibition
Cell System	Madin Darby canine kidney strain II (MDCKII) cells-OATP1B3
DT Modulation2	Paclitaxel inhibits the transportation of Bromsulphthalein by SLCO1B3 (IC50 = 4 microM)			[1]
Affected Drug/Substrate	Bromsulphthalein	Modulation Type	Inhibition
Cell System	Madin Darby canine kidney strain II (MDCKII) cells-OATP1B3
DT Modulation3	Paclitaxel inhibits the transportation of Estradiol-17beta-glucuronide by SLCO1B3 (IC50 = 0.5 microM)			[4]
Affected Drug/Substrate	Estradiol-17beta-glucuronide	Modulation Type	Inhibition
Cell System	Chinese hamster ovary (CHO) cells-OATP1B3
DT Modulation4	Paclitaxel inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
DT Modulation5	Paclitaxel inhibits the transportation of Fluorescein by SLCO1B3			[9]
Affected Drug/Substrate	Fluorescein	Modulation Type	Inhibition
Cell System	Chinese hamster ovary (CHO) cells-OATP1B1
DT Modulation6	Paclitaxel inhibits the transportation of Sincalide by SLCO1B3			[9]
Affected Drug/Substrate	Sincalide	Modulation Type	Inhibition
DT Modulation7	Paclitaxel inhibits the activity of SLCO1B3			[10]
Cyclosporine	11 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cyclosporine inhibits the transportation of Amantinin by SLCO1B3 (IC50 = 0.3 microM)			[1]
Affected Drug/Substrate	Amantinin	Modulation Type	Inhibition
Cell System	Madin Darby canine kidney strain II (MDCKII) cells-OATP1B3
DT Modulation2	Cyclosporine inhibits the transportation of Bosentan by SLCO1B3 (IC50 = 0.8 microM)			[2]
Affected Drug/Substrate	Bosentan	Modulation Type	Inhibition
Cell System	Chinese hamster ovary (CHO) cells-OATP1B1
DT Modulation3	Cyclosporine inhibits the transportation of Bromsulphthalein by SLCO1B3 (IC50 = 0.3 microM)			[1]
Affected Drug/Substrate	Bromsulphthalein	Modulation Type	Inhibition
Cell System	Madin Darby canine kidney strain II (MDCKII) cells-OATP1B3
DT Modulation4	Cyclosporine inhibits the transportation of Rosuvastatin by SLCO1B3 (IC50 = 0.06 microM)			[11]
Affected Drug/Substrate	Rosuvastatin	Modulation Type	Inhibition
Cell System	Human cervical cancer cell line (Hela)-OATP1B3
DT Modulation5	Cyclosporine inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Mitoxantrone	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Mitoxantrone inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
DT Modulation2	Mitoxantrone inhibits the transportation of Sincalide by SLCO1B3			[9]
Affected Drug/Substrate	Sincalide	Modulation Type	Inhibition
DT Modulation3	Mitoxantrone inhibits the activity of SLCO1B3			[14]
Montelukast	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Montelukast inhibits the transportation of Amantinin by SLCO1B3 (IC50 = 15 microM)			[1]
Affected Drug/Substrate	Amantinin	Modulation Type	Inhibition
Cell System	Madin Darby canine kidney strain II (MDCKII) cells-OATP1B3
DT Modulation2	Montelukast inhibits the transportation of Bromsulphthalein by SLCO1B3 (IC50 = 0.5 microM)			[1]
Affected Drug/Substrate	Bromsulphthalein	Modulation Type	Inhibition
Cell System	Madin Darby canine kidney strain II (MDCKII) cells-OATP1B3
Sildenafil	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sildenafil inhibits the transportation of Bosentan by SLCO1B3 (IC50 = 4 microM)			[2]
Affected Drug/Substrate	Bosentan	Modulation Type	Inhibition
Cell System	Chinese hamster ovary (CHO) cells-OATP1B1
DT Modulation2	Sildenafil inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Rifamycin SV	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Rifamycin SV inhibits the transportation of Bromsulphthalein by SLCO1B3 (Ki = 3 microM)			[5]
Affected Drug/Substrate	Bromsulphthalein	Modulation Type	Inhibition
Cell System	Oocytes-OATP1B3
DT Modulation2	Rifamycin SV inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Repaglinide	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Repaglinide inhibits the transportation of Bromsulphthalein by SLCO1B3 (IC50 = 5.6 microM)			[15]
Affected Drug/Substrate	Bromsulphthalein	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
DT Modulation2	Repaglinide inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Amprenavir	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Amprenavir inhibits the transportation of Cholyl-glycylamido-fluorescein by SLCO1B3 (IC50 = 19.1 microM; Ki = 13.1 microM)			[3]
Affected Drug/Substrate	Cholyl-glycylamido-fluorescein	Modulation Type	Inhibition
Cell System	Chinese hamster ovary (CHO) cells-OATP1B3
DT Modulation2	Amprenavir inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Atazanavir	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Atazanavir inhibits the transportation of Cholyl-glycylamido-fluorescein by SLCO1B3 (IC50 = 3 microM; Ki = 2 microM)			[3]
Affected Drug/Substrate	Cholyl-glycylamido-fluorescein	Modulation Type	Inhibition
Cell System	Chinese hamster ovary (CHO) cells-OATP1B3
DT Modulation2	Atazanavir inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Digoxin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Digoxin inhibits the transportation of Cholyl-glycylamido-fluorescein by SLCO1B3 (IC50 = 1 microM; Ki = 0.7 microM)			[3]
Affected Drug/Substrate	Cholyl-glycylamido-fluorescein	Modulation Type	Inhibition
Cell System	Chinese hamster ovary (CHO) cells-OATP1B3
DT Modulation2	Digoxin inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Indinavir	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Indinavir inhibits the transportation of Cholyl-glycylamido-fluorescein by SLCO1B3 (IC50 = 12.3 microM; Ki = 8.5 microM)			[3]
Affected Drug/Substrate	Cholyl-glycylamido-fluorescein	Modulation Type	Inhibition
Cell System	Chinese hamster ovary (CHO) cells-OATP1B3
DT Modulation2	Indinavir inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Lopinavir	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Lopinavir inhibits the transportation of Cholyl-glycylamido-fluorescein by SLCO1B3 (IC50 = 2 microM; Ki = 1.4 microM)			[3]
Affected Drug/Substrate	Cholyl-glycylamido-fluorescein	Modulation Type	Inhibition
Cell System	Chinese hamster ovary (CHO) cells-OATP1B3
DT Modulation2	Lopinavir inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Ritonavir	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ritonavir inhibits the transportation of Cholyl-glycylamido-fluorescein by SLCO1B3 (IC50 = 3.6 microM; Ki = 2.5 microM)			[3]
Affected Drug/Substrate	Cholyl-glycylamido-fluorescein	Modulation Type	Inhibition
Cell System	Chinese hamster ovary (CHO) cells-OATP1B3
DT Modulation2	Ritonavir inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Saquinavir	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Saquinavir inhibits the transportation of Cholyl-glycylamido-fluorescein by SLCO1B3 (IC50 = 4.1 microM; Ki = 2.8 microM)			[3]
Affected Drug/Substrate	Cholyl-glycylamido-fluorescein	Modulation Type	Inhibition
Cell System	Chinese hamster ovary (CHO) cells-OATP1B3
DT Modulation2	Saquinavir inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Estradiol	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Estradiol inhibits the transportation of Estradiol-17beta-glucuronide by SLCO1B3 (IC50 = 12.9 microM)			[4]
Affected Drug/Substrate	Estradiol-17beta-glucuronide	Modulation Type	Inhibition
Cell System	Chinese hamster ovary (CHO) cells-OATP1B3
DT Modulation2	Estradiol inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Mifepristone	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Mifepristone inhibits the transportation of Estradiol-17beta-glucuronide by SLCO1B3 (IC50 = 5.3 microM)			[4]
Affected Drug/Substrate	Estradiol-17beta-glucuronide	Modulation Type	Inhibition
Cell System	Chinese hamster ovary (CHO) cells-OATP1B3
DT Modulation2	Mifepristone inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Fexofenadine	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Fexofenadine inhibits the transportation of Estrone sulfate by SLCO1B3 (Ki = 205 microM)			[17]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
DT Modulation2	Fexofenadine inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Probenecid	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Probenecid inhibits the transportation of Fexofenadine by SLCO1B3 (Ki = 130 microM)			[18]
Affected Drug/Substrate	Fexofenadine	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
DT Modulation2	Probenecid inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
DT Modulation3	Probenecid inhibits the transporation of ginkolide B by SLCO1B3			[25]
Affected Drug/Substrate	Ginkgolide B	Modulation Type	Inhibition
Cell System	Human enterocyte-like 2 cell (Caco-2)
Diclofenac	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Diclofenac inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
DT Modulation2	Diclofenac inhibits the activity of SLCO1B3			[22]
Doxorubicin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Doxorubicin inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
DT Modulation2	Doxorubicin inhibits the transportation of Sincalide by SLCO1B3			[9]
Affected Drug/Substrate	Sincalide	Modulation Type	Inhibition
Etoposide	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Etoposide inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
DT Modulation2	Etoposide inhibits the transportation of Sincalide by SLCO1B3			[9]
Affected Drug/Substrate	Sincalide	Modulation Type	Inhibition
Irinotecan	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Irinotecan inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
DT Modulation2	Irinotecan inhibits the transportation of Sincalide by SLCO1B3			[9]
Affected Drug/Substrate	Sincalide	Modulation Type	Inhibition
Tamoxifen	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tamoxifen inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
DT Modulation2	Tamoxifen inhibits the transportation of Sincalide by SLCO1B3			[9]
Affected Drug/Substrate	Sincalide	Modulation Type	Inhibition
Vinblastine	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Vinblastine inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
DT Modulation2	Vinblastine inhibits the transportation of Sincalide by SLCO1B3			[9]
Affected Drug/Substrate	Sincalide	Modulation Type	Inhibition
Vincristine	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Vincristine inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
DT Modulation2	Vincristine inhibits the transportation of Sincalide by SLCO1B3			[9]
Affected Drug/Substrate	Sincalide	Modulation Type	Inhibition
Decitabine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Decitabine inhibits DNA methyltransferase, which then enhances the expression of SLCO1B3 via downregulating the promoter hypermethylation level			[23]
Cell System	Human enterocyte-like 2 cell (Caco-2)
Darunavir	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Darunavir inhibits the transportation of Cholyl-glycylamido-fluorescein by SLCO1B3 (IC50 = 4.8 microM; Ki = 3.3 microM)			[3]
Affected Drug/Substrate	Cholyl-glycylamido-fluorescein	Modulation Type	Inhibition
Cell System	Chinese hamster ovary (CHO) cells-OATP1B3
Troglitazone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Troglitazone inhibits the transportation of Estradiol-17beta-glucuronide by SLCO1B3 (IC50 = 15.7 microM)			[4]
Affected Drug/Substrate	Estradiol-17beta-glucuronide	Modulation Type	Inhibition
Cell System	Chinese hamster ovary (CHO) cells-OATP1B3
Telaprevir	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Telaprevir inhibits the activity of SLCO1B3 (IC50 = 0.0068 microM)			[27]
Boceprevir	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Boceprevir inhibits the activity of SLCO1B3 (IC50 = 4.9 microM)			[28]
Mesalazine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Mesalazine inhibits the transportation of Bromsulphthalein by SLCO1B3			[29]
Affected Drug/Substrate	Bromsulphthalein	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Acarbose	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Acarbose inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Acyclovir	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Acyclovir inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Allopurinol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Allopurinol inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Amantadine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Amantadine inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Amitriptyline	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Amitriptyline inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Amodiaquine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Amodiaquine inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Atenolol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Atenolol inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Atomoxetine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Atomoxetine inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Atorvastatin	8 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Atorvastatin inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
DT Modulation2	glimepiride affects the reaction SLCO1B3 protein results in increased uptake of Atorvastatin			[69]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Glyburide inhibits the reaction SLCO1B3 protein results in increased uptake of Atorvastatin			[69]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Nateglinide inhibits the reaction SLCO1B3 protein results in increased uptake of Atorvastatin			[69]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	repaglinide inhibits the reaction SLCO1B3 protein results in increased uptake of Atorvastatin			[69]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Rosiglitazone inhibits the reaction SLCO1B3 protein results in increased uptake of Atorvastatin			[69]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	SLCO1B3 protein results in increased uptake of Atorvastatin			[69]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	Sulfobromophthalein inhibits the reaction SLCO1B3 protein results in increased uptake of Atorvastatin			[70]
Regulation Mechanism				Transcription Factor Info
Benzbromarone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Benzbromarone inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Bestatin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Bestatin inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Budesonide	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Budesonide inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Bupropion	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Bupropion inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Buspirone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Buspirone inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Caffeine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Caffeine inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Candesartan	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Candesartan inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Captopril	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Captopril inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Carbamazepine	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Carbamazepine inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Cefadroxil	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cefadroxil inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Cefamandole	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cefamandole inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Celecoxib	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Celecoxib inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Cerivastatin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cerivastatin inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Cetirizine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cetirizine inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Chloroquine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Chloroquine inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Chlorpromazine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Chlorpromazine inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Chlorprothixene	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Chlorprothixene inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Chlorzoxazone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Chlorzoxazone inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Cholic Acid	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cholic acid inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Cimetidine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cimetidine inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Clarithromycin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Clarithromycin inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Clotrimazole	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Clotrimazole inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Colchicine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Colchicine inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Desipramine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Desipramine inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Dexamethasone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Dexamethasone inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Dextromethorphan	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Dextromethorphan inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Diazepam	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Diazepam inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Diethylstilbestrol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Diethylstilbestrol inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Diltiazem	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Diltiazem inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Dipyridamole	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Dipyridamole inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Disopyramide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Disopyramide inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Disulfiram	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Disulfiram inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Dofetilide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Dofetilide inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Doxazosin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Doxazosin inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Efavirenz	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Efavirenz inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Eletriptan	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Eletriptan inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Emtricitabine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Emtricitabine inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Enalapril	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Enalapril inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Erlotinib	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Erlotinib inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Erythromycin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Erythromycin inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Ezetimibe	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ezetimibe inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Felodipine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Felodipine inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Fenofibrate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Fenofibrate inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Fentanyl	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Fentanyl inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Fluconazole	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Fluconazole inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Fluoxetine	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Fluoxetine inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Flutamide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Flutamide inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Fluvastatin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Fluvastatin inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Fluvoxamine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Fluvoxamine inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Furosemide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Furosemide inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Gemfibrozil	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Gemfibrozil inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Glyburide	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Glibenclamide inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Glipizide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Glipizide inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Ibuprofen	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ibuprofen inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Imipramine	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Imipramine inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Indocyanine green	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Indocyanine green inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Indomethacin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Indomethacin inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Isoniazid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Isoniazid inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Isradipine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Isradipine inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Ivermectin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ivermectin inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Ketoconazole	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ketoconazole inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Lamotrigine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Lamotrigine inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Lansoprazole	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Lansoprazole inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
L-carnitine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	L-carnitine inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Levofloxacin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Levofloxacin inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Levothyroxine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Levothyroxine inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Lisinopril	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Lisinopril inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Loperamide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Loperamide inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Loratadine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Loratadine inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Lovastatin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Lovastatin inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Mephenytoin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Mephenytoin inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Metformin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Metformin inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Methotrexate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Methotrexate inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Methoxsalen	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Methoxsalen inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Metoprolol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Metoprolol inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Midazolam	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Midazolam inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Moclobemide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Moclobemide inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Nefazodone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Nefazodone inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Nelfinavir	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Nelfinavir inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Nicardipine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Nicardipine inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Nicotine polacrilex	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Nicotine inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Nifedipine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Nifedipine inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Nitrofurantoin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Nitrofurantoin inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Novobiocin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Novobiocin inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Nystatin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Nystatin inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Olmesartan medoxomil	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Olmesartan medoxomil inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Omeprazole	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Omeprazole inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Ondansetron	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ondansetron inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Ouabain	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ouabain inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Pantoprazole	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Pantoprazole inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Paroxetine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Paroxetine inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Phenobarbital	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Phenobarbital inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Phenylbutazone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Phenylbutazone inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Phenytoin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Phenytoin inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Pilsicainide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Pilsicainide inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Pindolol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Pindolol inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Pioglitazone	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Pioglitazone inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Piroxicam	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Piroxicam inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Pravastatin	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Pravastatin inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Prazosin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Prazosin inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Prednisolone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Prednisolone inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Procainamide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Procainamide inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Progesterone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Progesterone inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Propranolol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Propranolol inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Quercetin	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Quercetin inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Quinine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Quinine inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Ranolazine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ranolazine inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Reserpine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Reserpine inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Rosuvastatin Calcium	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Rosuvastatin inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Sanguinarine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sanguinarine inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Simvastatin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Simvastatin inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Sotalol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sotalol inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Spironolactone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Spironolactone inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Sulfaphenazole	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sulfaphenazole inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Sulfasalazine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sulfasalazine inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Telmisartan	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Telmisartan inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Tenofovir	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tenofovir inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Testosterone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Testosterone inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Tetracycline	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tetracycline inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Theophylline	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Theophylline inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Thioridazine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Thioridazine inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Thiotepa	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Thiotepa inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Ticlopidine	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ticlopidine inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Tipranavir	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tipranavir inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Tolbutamide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tolbutamide inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Topotecan	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Topotecan inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Triazolam	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Triazolam inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Trimethoprim	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Trimethoprim inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Valacyclovir	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Valacyclovir inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Valproic Acid	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Valproic Acid inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Valsartan	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Valsartan inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Varenicline	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Varenicline inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Verapamil	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Verapamil inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Warfarin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Warfarin inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Zidovudine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Zidovudine inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Linagliptin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Linagliptin inhibits the transportation of Sincalide by SLCO1B3			[7]
Affected Drug/Substrate	Sincalide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Eltrombopag	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Eltrombopag inhibits the transportation of Estradiol-17beta-glucuronide by SLCO1B3			[13]
Affected Drug/Substrate	Estradiol-17beta-glucuronide	Modulation Type	Inhibition
Chlorambucil	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Chlorambucil inhibits the transportation of Sincalide by SLCO1B3			[9]
Affected Drug/Substrate	Sincalide	Modulation Type	Inhibition
Prednisone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Prednisone inhibits the transportation of Sincalide by SLCO1B3			[9]
Affected Drug/Substrate	Sincalide	Modulation Type	Inhibition
Carfilzomib	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Carfilzomib inhibits the activity of SLCO1B3			[31]
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Calcitriol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Calcitriol increases the expression of SLCO1B3			[34]
Deoxycholic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Deoxycholic acid increases the expression of SLCO1B3			[35]
Rifampin	11 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Rifampin inhibits the expression of SLCO1B3			[36]
Cisplatin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cisplatin inhibits the expression of SLCO1B3			[37]
Obeticholic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Obeticholic acid increases the expression of SLCO1B3			[38]
Temozolomide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Temozolomide increases the expression of SLCO1B3			[39]
Chenodeoxycholic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Chenodeoxycholic acid increases the expression of SLCO1B3			[40]
Rifaximin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Rifaximin inhibits the activity of SLCO1B3			[41]
Letermovir	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Letermovir inhibits the activity of SLCO1B3			[42]
Telithromycin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Telithromycin inhibits the activity of SLCO1B3			[43]
Dactinomycin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Dactinomycin inhibits the activity of SLCO1B3			[14]
Docetaxel	6 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Docetaxel inhibits the activity of SLCO1B3			[14]
Glecaprevir	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Glecaprevir inhibits the activity of SLCO1B3			[44]
Selexipag	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Selexipag inhibits the activity of SLCO1B3			[45]
Itraconazole	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Itraconazole inhibits the activity of SLCO1B3			[46]
Acetaminophen	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Acetaminophen results in decreased activity of SLCO1B3 protein			[62]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Acetaminophen results in decreased expression of SLCO1B3 mRNA			[63]
Regulation Mechanism				Transcription Factor Info
Drug in Phase 4 Trial
Berberine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Berberine inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Drug in Phase 2/3 Trial
Silibinin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Silibinin inhibits the transportation of Estradiol-17beta-glucuronide by SLCO1B3			[24]
Affected Drug/Substrate	Estradiol-17beta-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Drug in Phase 3 Trial
Benzylpenicillin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Benzylpenicillin inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Glycyrrhizic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Glycyrrhizin inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Oltipraz	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Oltipraz inhibits the expression of SLCO1B3			[47]
Icariin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Icariin inhibits the activity of SLCO1B3			[48]
Fusidic Acid	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Fusidic Acid inhibits the activity of SLCO1B3			[53]
Asunaprevir	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Asunaprevir inhibits the activity of SLCO1B3			[58]
Drug in Phase 2 Trial
Genistein	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Genistein inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Drug in Phase 1/2 Trial
Sodium taurocholate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sodium taurocholate inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Drug in Phase 1 Trial
Naringenin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Naringenin inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
TAK-875	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	TAK-875 inhibits the activity of SLCO1B3			[55]
Drug in Preclinical Test
(+)-JQ1	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	(+)-JQ1 inhibits the expression of SLCO1B3			[51]
Discontinued Drug
MK-571	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	MK-571 inhibits the transportation of Amantinin by SLCO1B3 (IC50 = 0.5 microM; Ki = 0.2 microM)			[1]
Affected Drug/Substrate	Amantinin	Modulation Type	Inhibition
Cell System	Madin Darby canine kidney strain II (MDCKII) cells-OATP1B3
DT Modulation2	MK-571 inhibits the transportation of Bromsulphthalein by SLCO1B3 (IC50 = 0.3 microM)			[1]
Affected Drug/Substrate	Bromsulphthalein	Modulation Type	Inhibition
Cell System	Madin Darby canine kidney strain II (MDCKII) cells-OATP1B3
DT Modulation3	MK-571 inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Baicalin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Baicalin inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Elacridar	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Elacridar inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Valspodar	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Valspodar inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Investigative Drug
Dioscin	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Dioscin inhibits the transportation of Cyclosporine by SLCO1B3			[12]
Affected Drug/Substrate	Cyclosporine	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
DT Modulation2	Dioscin inhibits the transportation of Epigalocatechin gallate by SLCO1B3			[12]
Affected Drug/Substrate	Epigalocatechin gallate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
DT Modulation3	Dioscin inhibits the transportation of Rifampicin by SLCO1B3			[12]
Affected Drug/Substrate	Rifampicin	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
DT Modulation4	Dioscin inhibits the transportation of Telmisartan by SLCO1B3			[12]
Affected Drug/Substrate	Telmisartan	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Bromsulphthalein	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Bromsulphthalein inhibits the transportation of Amantinin by SLCO1B3 (IC50 = 3 microM)			[1]
Affected Drug/Substrate	Amantinin	Modulation Type	Inhibition
Cell System	Madin Darby canine kidney strain II (MDCKII) cells-OATP1B3
DT Modulation2	Bromsulphthalein inhibits the transportation of Cholyl-glycylamido-fluorescein by SLCO1B3 (IC50 = 1.4 microM; Ki = 1 microM)			[3]
Affected Drug/Substrate	Cholyl-glycylamido-fluorescein	Modulation Type	Inhibition
Cell System	Chinese hamster ovary (CHO) cells-OATP1B3
DT Modulation3	Bromsulphthalein inhibits the transportation of Estradiol-17beta-glucuronide by SLCO1B3			[13]
Affected Drug/Substrate	Estradiol-17beta-glucuronide	Modulation Type	Inhibition
Sincalide	5 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sincalide inhibits the transportation of Amantinin by SLCO1B3 (IC50 = 10 microM)			[1]
Affected Drug/Substrate	Amantinin	Modulation Type	Inhibition
Cell System	Madin Darby canine kidney strain II (MDCKII) cells-OATP1B3
DT Modulation2	Sincalide inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Lithocholic Acid	5 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Lithocholate inhibits the transportation of Estradiol-17beta-glucuronide by SLCO1B3 (IC50 = 6.8 microM)			[4]
Affected Drug/Substrate	Estradiol-17beta-glucuronide	Modulation Type	Inhibition
Cell System	Chinese hamster ovary (CHO) cells-OATP1B3
Estrone sulfate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Estrone sulfate inhibits the transportation of Sincalide by SLCO1B3 (IC50 = 97.1 microM)			[26]
Affected Drug/Substrate	Sincalide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Aminohippuric acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Aminohippuric acid inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Chelerythrine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Chelerythrine inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Coumarin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Coumarin inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Coumestrol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Coumestrol inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Daidzein	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Daidzein inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Glycochenodeoxycholic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Glycochenodeoxycholic acid inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Glycocholic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Glycocholic acid inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Glycodeoxycholic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Glycodeoxycholic acid inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Morin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Morin inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Naringin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Naringin inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Phalloidin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Phalloidin inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Taurochenodeoxycholate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Taurochenodeoxycholate inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Tetraethylammonium	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tetraethylammonium inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Estradiol-17beta-glucuronide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Estradiol-17beta-glucuronide modulates the activity of SLCO1B3			[59]
Drug Withdrawn
Astemizole	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Astemizole inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Fendiline	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Fendiline inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Phenacetin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Phenacetin inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Phenformin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Phenformin inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Terfenadine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Terfenadine inhibits the transportation of Estradiol 17b-D-glucuronide by SLCO1B3			[6]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Natural Product
Cigarette smoke condensate	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cigarette smoke condensate inhibits the transportation of Cholecystokinin octapeptide sulphated by SLCO1B3 (IC50 = 7.6 microM)			[16]
Affected Drug/Substrate	Cholecystokinin octapeptide sulphated	Modulation Type	Inhibition
Cell System	Human hepatoma HepaRG cells-OATP1B3
DT Modulation2	Cigarette smoke condensate inhibits the activity of SLCO1B3 (IC50 = 7.6 microM)			[20]
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Green tea	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Green tea inhibits the transportation of Atorvastatin by SLCO1B3			[21]
Affected Drug/Substrate	Atorvastatin	Modulation Type	Inhibition
Cell System	Human enterocyte-like 2 cell (Caco-2)-OATP1B3
DT Modulation2	Green tea inhibits the transportation of Bromosulfophtalein by SLCO1B3			[21]
Affected Drug/Substrate	Bromosulfophtalein	Modulation Type	Inhibition
Cell System	Human enterocyte-like 2 cell (Caco-2)-OATP1B3
Silybin A	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Silybin A inhibits the transportation of Estradiol-17-glucuronide by SLCO1B3 (IC50 = 2.7 microM)			[24]
Affected Drug/Substrate	Estradiol-17-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Silybin B	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Silybin B inhibits the transportation of Estradiol-17-glucuronide by SLCO1B3 (IC50 = 5 microM)			[24]
Affected Drug/Substrate	Estradiol-17-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Silychristin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Silychristin inhibits the transportation of Estradiol-17-glucuronide by SLCO1B3 (IC50 = 36.4 microM)			[24]
Affected Drug/Substrate	Estradiol-17-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Silibinin dihemisuccinate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Silibinin dihemisuccinate inhibits the transportation of H-amanitin by SLCO1B3 (IC50 = 1 microM; Ki = 2.1 microM)			[1]
Affected Drug/Substrate	H-amanitin	Modulation Type	Inhibition
Cell System	Madin darby canine kidney strain II cell line (MDCKII)-OATP1B3
DT Modulation1	Quercetin inhibits the reaction SLCO1B3 protein results in increased import of Sulfobromophthalein			[67]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	SLCO1B3 protein results in increased uptake of Quercetin			[97]
Regulation Mechanism				Transcription Factor Info
Pomegranat	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Pomegranat inhibits the uptake of Cholecystokinin by SLCO1B3 (IC50 = 1.6 microM)			[30]
Affected Drug/Substrate	Cholecystokinin	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)
DT Modulation2	Pomegranat inhibits the uptake of Fluorescein-methotrexate by SLCO1B3 (IC50 = 0.365 microM)			[19]
Affected Drug/Substrate	Fluorescein-methotrexate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)
Silymarin flavolignans	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Silymarin flavolignans inhibits the transportation of Estradiol-17-glucuronide by SLCO1B3			[24]
Affected Drug/Substrate	Estradiol-17-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OATP1B3
Milk thistle	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Milk thistle inhibits the uptake of Estradiol-17-glucuronide by SLCO1B3 (IC50 = 2.2 microM)			[24]
Affected Drug/Substrate	Estradiol-17-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)
Mix silybin A silybin B	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Mix silybin A silybin B inhibits the activity of SLCO1B3			[32]
Cell System	Chinese hamster ovary (CHO) cells-OATP1B3
Epicatechin gallate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	(-)-epicatechin-3-gallate inhibits the activity of SLCO1B3 in a concentration-dependent way			[33]
Cell System	Chinese hamster ovary (CHO) cells-OATP1B3
Particulate Matter	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Particulate Matter inhibits the expression of SLCO1B3			[49]
Senecionine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Senecionine inhibits the expression of SLCO1B3			[50]
Tobacco Smoke Pollution	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tobacco Smoke Pollution inhibits the expression of SLCO1B3			[56]
Traditional Medicine
Jinfukang	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Jinfukang inhibits the expression of SLCO1B3			[37]
Dietary Constituent
Apple peel Olives	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Apple peel Olives inhibits the uptake of Fluorescein derivatives by SLCO1B3 (IC50 = 0.368 microM)			[19]
Affected Drug/Substrate	Fluorescein derivatives	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)
Environmental toxicant
Tetrabromobisphenol A	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tetrabromobisphenol A inhibits the activity of SLCO1B3			[54]
Polychlorinated dibenzodioxin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Polychlorinated dibenzodioxin inhibits the expression of SLCO1B3			[57]
Mycotoxins
Aflatoxin B1	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Aflatoxin B1 inhibits the expression of SLCO1B3			[52]
DT Modulation2	Aflatoxin B1 affects the expression of SLCO1B3 protein			[64]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Aflatoxin B1 results in decreased methylation of SLCO1B3 gene			[52]
Regulation Mechanism				Transcription Factor Info
ochratoxin A	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLCO1B3 protein results in increased transport of ochratoxin A			[94]
Regulation Mechanism				Transcription Factor Info
Zearalenone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Zearalenone results in decreased activity of SLCO1B3 protein			[108]
Regulation Mechanism				Transcription Factor Info

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87	Identification of the organic anion transporting polypeptides responsible for the hepatic uptake of the major metabolite of epyrifenacil, S-3100-CA, in mice. Pharmacol Res Perspect. 2021;9(5):e00877.
88	Involvement of multiple efflux transporters in hepatic disposition of fexofenadine. Mol Pharmacol. 2008 May;73(5):1474-83.
89	Human hepatobiliary transport of organic anions analyzed by quadruple-transfected cells. Mol Pharmacol. 2005 Oct;68(4):1031-8.
90	The Antimicrobial Agent Fusidic Acid Inhibits Organic Anion Transporting Polypeptide-Mediated Hepatic Clearance and May Potentiate Statin-Induced Myopathy. Drug Metab Dispos. 2016;44(5):692-9.
91	Molecular mechanisms governing different pharmacokinetics of ginsenosides and potential for ginsenoside-perpetrated herb-drug interactions on OATP1B3. Br J Pharmacol. 2015;172(4):1059-73.
92	Transcellular movement of hydroxyurea is mediated by specific solute carrier transporters. Exp Hematol. 2011 Apr;39(4):446-56.
93	Uremic solutes modulate hepatic bile acid handling and induce mitochondrial toxicity. Toxicol In Vitro. 2019;56:52-61.
94	Human organic anion transporting polypeptide (OATP) 1B3 and mouse OATP1A/1B affect liver accumulation of Ochratoxin A in mice. Toxicol Appl Pharmacol. 2020;401:115072.
95	Organic Anion Transporting Polypeptides Contribute to the Disposition of Perfluoroalkyl Acids in Humans and Rats. Toxicol Sci. 2017;156(1):84-95.
96	In vitro inhibition of OATP-mediated uptake of phalloidin using bile acid derivatives. Toxicol Appl Pharmacol. 2009;239(1):13-20.
97	Organic anion transporting polypeptides and organic cation transporter 1 contribute to the cellular uptake of the flavonoid quercetin. Naunyn Schmiedebergs Arch Pharmacol. 2014;387(9):883-91.
98	UGT-dependent regioselective glucuronidation of ursodeoxycholic acid and obeticholic acid and selective transport of the consequent acyl glucuronides by OATP1B1 and 1B3. Chem Biol Interact. 2019;310:108745.
99	Involvement of aryl hydrocarbon receptor in the cytotoxicity of corannulene and its derivatives. Toxicol Lett. 2020 Mar 15;321:114-121.
100	Neonicotinoid pesticides poorly interact with human drug transporters. J Biochem Mol Toxicol. 2019 Oct;33(10):e22379.
101	Vectorial transport of the peptide CCK-8 by double-transfected MDCKII cells stably expressing the organic anion transporter OATP1B3 (OATP8) and the export pump ABCC2. J Pharmacol Exp Ther. 2005;313(2):549-56.
102	Development of a liver-targeted stearoyl-CoA desaturase (SCD) inhibitor (MK-8245) to establish a therapeutic window for the treatment of diabetes and dyslipidemia. J Med Chem. 2011;54(14):5082-96.
103	Fasiglifam (TAK-875) Alters Bile Acid Homeostasis in Rats and Dogs: A Potential Cause of Drug Induced Liver Injury. Toxicol Sci. 2017;157(1):50-61.
104	Cross-species comparisons of transcriptomic alterations in human and rat primary hepatocytes exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol Sci. 2012 May;127(1):199-215.
105	Expression of drug transporters and drug metabolizing enzymes in the bladder urothelium in man and affinity of the bladder spasmolytic trospium chloride to transporters likely involved in its pharmacokinetics. Mol Pharm. 2015 Jan 5;12(1):171-8.
106	Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
107	Identification of two novel genes SLC15A2 and SLCO1B3 associated with maintenance dose variability of warfarin in a Chinese population. Sci Rep. 2017 Dec 12;7(1):17379.
108	Interaction of mycotoxins zearalenone, zearalenol, and zearalenol with cytochrome P450 (CYP1A2, 2C9, 2C19, 2D6, and 3A4) enzymes and organic anion transporting polypeptides (OATP1A2, OATP1B1, OATP1B3, and OATP2B1). Toxicol In Vitro. 2024;96:105789.

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