Detail Information of Exogenous Modulation

General Information of Drug Transporter (DT)
DT ID	DTD0026 Transporter Info
Gene Name	SLC22A11
Transporter Name	Organic anion transporter 4
Gene ID	55867
UniProt ID	Q9NSA0

Exogenous factors (drugs, dietary constituents, etc.) Modulation of This DT (EGM)
Chemical Compound
DT Modulation1	Probenecid inhibits the reaction SLC22A11 protein affects the transport of estrone sulfate			[25]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Probenecid inhibits the reaction SLC22A11 protein results in increased import of 6-carboxyfluorescein			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Probenecid inhibits the reaction SLC22A11 protein results in increased import of estrone sulfate			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Probenecid inhibits the reaction SLC22A11 protein results in increased import of perfluorooctanoic acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Probenecid inhibits the reaction SLC22A11 protein results in increased uptake of 6-carboxyfluorescein			[16]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Probenecid inhibits the reaction SLC22A11 protein results in increased uptake of Thyroxine			[35]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	Probenecid inhibits the reaction SLC22A11 results in increased uptake of Aristolochic Acids which results in increased chemical synthesis of 7-(deoxyadenosin-N(6)-yl)aristolactam I			[27]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	Probenecid inhibits the reaction SLC22A11 results in increased uptake of Aristolochic Acids which results in increased chemical synthesis of 7-(deoxyguanosin-N(2)-yl)aristolactam I			[27]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	Probenecid results in decreased activity of SLC22A11 protein			[44]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Piroxicam results in decreased activity of SLC22A11 protein			[6]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Bumetanide inhibits the reaction SLC22A11 protein affects the transport of estrone sulfate			[25]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Furosemide inhibits the reaction SLC22A11 protein affects the transport of estrone sulfate			[25]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Diclofenac inhibits the reaction SLC22A11 protein affects the transport of estrone sulfate			[25]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Diclofenac inhibits the reaction SLC22A11 protein results in increased uptake of Thyroxine			[35]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Diclofenac results in decreased activity of SLC22A11 protein			[6]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Indomethacin inhibits the reaction SLC22A11 protein affects the transport of estrone sulfate			[25]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Indomethacin results in decreased activity of SLC22A11 protein			[6]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Ketoprofen results in decreased activity of SLC22A11 protein			[6]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	SLC22A11 protein results in increased uptake of Ketoprofen			[6]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Mefenamic Acid results in decreased activity of SLC22A11 protein			[6]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Naproxen results in decreased activity of SLC22A11 protein			[6]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Sulindac results in decreased activity of SLC22A11 protein			[6]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Salicylic Acid results in decreased activity of SLC22A11 protein			[6]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	SLC22A11 protein results in increased uptake of Salicylic Acid			[6]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Phenacetin results in decreased activity of SLC22A11 protein			[6]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Benzo(a)pyrene results in increased methylation of SLC22A11 promoter			[33]
Regulation Mechanism				Transcription Factor Info
2,4,6-tribromophenol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	2,4,6-tribromophenol results in increased expression of SLC22A11 mRNA			[22]
Regulation Mechanism				Transcription Factor Info
4-methylumbelliferyl sulfate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	4-methylumbelliferyl sulfate inhibits the reaction SLC22A11 protein affects the transport of estrone sulfate			[25]
Regulation Mechanism				Transcription Factor Info
4-nitrophenyl sulfate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	4-nitrophenyl sulfate inhibits the reaction SLC22A11 protein affects the transport of estrone sulfate			[25]
Regulation Mechanism				Transcription Factor Info
6-carboxyfluorescein	7 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	glutaric acid promotes the reaction SLC22A11 protein results in increased import of 6-carboxyfluorescein			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	p-Aminohippuric Acid promotes the reaction SLC22A11 protein results in increased import of 6-carboxyfluorescein			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Probenecid inhibits the reaction SLC22A11 protein results in increased import of 6-carboxyfluorescein			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Probenecid inhibits the reaction SLC22A11 protein results in increased uptake of 6-carboxyfluorescein			[16]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	SLC22A11 protein results in increased import of 6-carboxyfluorescein			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	SLC22A11 protein results in increased uptake of 6-carboxyfluorescein			[16]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	Sulpiride inhibits the reaction SLC22A11 protein results in increased uptake of 6-carboxyfluorescein			[16]
Regulation Mechanism				Transcription Factor Info
7-(deoxyadenosin-N(6)-yl)aristolactam I	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Probenecid inhibits the reaction SLC22A11 results in increased uptake of Aristolochic Acids which results in increased chemical synthesis of 7-(deoxyadenosin-N(6)-yl)aristolactam I			[27]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	SLC22A11 results in increased uptake of Aristolochic Acids which results in increased chemical synthesis of 7-(deoxyadenosin-N(6)-yl)aristolactam I			[27]
Regulation Mechanism				Transcription Factor Info
7-(deoxyguanosin-N(2)-yl)aristolactam I	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Probenecid inhibits the reaction SLC22A11 results in increased uptake of Aristolochic Acids which results in increased chemical synthesis of 7-(deoxyguanosin-N(2)-yl)aristolactam I			[27]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	SLC22A11 results in increased uptake of Aristolochic Acids which results in increased chemical synthesis of 7-(deoxyguanosin-N(2)-yl)aristolactam I			[27]
Regulation Mechanism				Transcription Factor Info
8-Bromo Cyclic Adenosine Monophosphate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	8-Bromo Cyclic Adenosine Monophosphate results in increased expression of SLC22A11 mRNA			[28]
Regulation Mechanism				Transcription Factor Info
aristolochic acid I	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	aristolochic acid I inhibits the reaction SLC22A11 results in increased uptake of estrone sulfate			[27]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	aristolochic acid I promotes the reaction SLC22A11 results in increased export of p-Aminohippuric Acid			[27]
Regulation Mechanism				Transcription Factor Info
benzo(e)pyrene	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	benzo(e)pyrene results in decreased methylation of SLC22A11 intron			[29]
Regulation Mechanism				Transcription Factor Info
beta-Naphthoflavone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	beta-Naphthoflavone results in decreased expression of SLC22A11 mRNA			[24]
Regulation Mechanism				Transcription Factor Info
bisphenol A	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	bisphenol A results in decreased expression of SLC22A11 protein			[22]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	bisphenol A results in increased methylation of SLC22A11 gene			[34]
Regulation Mechanism				Transcription Factor Info
bisphenol AF	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	bisphenol AF inhibits the reaction SLC22A11 protein results in increased uptake of Thyroxine			[35]
Regulation Mechanism				Transcription Factor Info
bisphenol F	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	bisphenol F inhibits the reaction SLC22A11 protein results in increased uptake of Thyroxine			[35]
Regulation Mechanism				Transcription Factor Info
butyraldehyde	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	butyraldehyde results in decreased expression of SLC22A11 mRNA			[21]
Regulation Mechanism				Transcription Factor Info
CGP 52608	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	CGP 52608 promotes the reaction RORA protein binds to SLC22A11 gene			[36]
Regulation Mechanism				Transcription Factor Info
Corticosterone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Corticosterone inhibits the reaction SLC22A11 protein affects the transport of estrone sulfate			[25]
Regulation Mechanism				Transcription Factor Info
daidzein	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	daidzein inhibits the reaction SLC22A11 protein results in increased transport of estrone sulfate			[37]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	daidzein metabolite inhibits the reaction SLC22A11 protein results in increased transport of estrone sulfate			[37]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	estrone sulfate inhibits the reaction SLC22A11 protein results in increased transport of daidzein metabolite			[37]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	SLC22A11 protein results in increased transport of daidzein metabolite			[37]
Regulation Mechanism				Transcription Factor Info
decabromobiphenyl ether	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	decabromobiphenyl ether results in increased expression of SLC22A11 protein			[22]
Regulation Mechanism				Transcription Factor Info
Dehydroepiandrosterone Sulfate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLC22A11 protein affects the transport of Dehydroepiandrosterone Sulfate			[25]
Regulation Mechanism				Transcription Factor Info
Enalaprilat	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLC22A11 protein results in increased uptake of Enalaprilat			[38]
Regulation Mechanism				Transcription Factor Info
estrone sulfate	30 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	4-methylumbelliferyl sulfate inhibits the reaction SLC22A11 protein affects the transport of estrone sulfate			[25]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	4-nitrophenyl sulfate inhibits the reaction SLC22A11 protein affects the transport of estrone sulfate			[25]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	aristolochic acid I inhibits the reaction SLC22A11 results in increased uptake of estrone sulfate			[27]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Bumetanide inhibits the reaction SLC22A11 protein affects the transport of estrone sulfate			[25]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Corticosterone inhibits the reaction SLC22A11 protein affects the transport of estrone sulfate			[25]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	daidzein inhibits the reaction SLC22A11 protein results in increased transport of estrone sulfate			[37]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	daidzein metabolite inhibits the reaction SLC22A11 protein results in increased transport of estrone sulfate			[37]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	Diclofenac inhibits the reaction SLC22A11 protein affects the transport of estrone sulfate			[25]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	estradiol sulfate inhibits the reaction SLC22A11 protein affects the transport of estrone sulfate			[25]
Regulation Mechanism				Transcription Factor Info
DT Modulation10	estrone sulfate inhibits the reaction SLC22A11 protein results in increased transport of daidzein metabolite			[37]
Regulation Mechanism				Transcription Factor Info
DT Modulation11	estrone sulfate promotes the reaction SLC22A11 results in increased export of p-Aminohippuric Acid			[27]
Regulation Mechanism				Transcription Factor Info
DT Modulation12	Furosemide inhibits the reaction SLC22A11 protein affects the transport of estrone sulfate			[25]
Regulation Mechanism				Transcription Factor Info
DT Modulation13	glutaric acid promotes the reaction SLC22A11 protein results in increased import of estrone sulfate			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation14	Ibuprofen inhibits the reaction SLC22A11 protein affects the transport of estrone sulfate			[25]
Regulation Mechanism				Transcription Factor Info
DT Modulation15	Indomethacin inhibits the reaction SLC22A11 protein affects the transport of estrone sulfate			[25]
Regulation Mechanism				Transcription Factor Info
DT Modulation16	naphthyl sulfate inhibits the reaction SLC22A11 protein affects the transport of estrone sulfate			[25]
Regulation Mechanism				Transcription Factor Info
DT Modulation17	Oxypurinol inhibits the reaction SLC22A11 protein results in increased uptake of estrone sulfate			[39]
Regulation Mechanism				Transcription Factor Info
DT Modulation18	p-Aminohippuric Acid promotes the reaction SLC22A11 protein results in increased import of estrone sulfate			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation19	perfluorodecanoic acid inhibits the reaction SLC22A11 protein results in increased import of estrone sulfate			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation20	perfluoro-n-heptanoic acid inhibits the reaction SLC22A11 protein results in increased import of estrone sulfate			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation21	perfluoro-n-nonanoic acid inhibits the reaction SLC22A11 protein results in increased import of estrone sulfate			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation22	perfluorooctanoic acid inhibits the reaction SLC22A11 protein results in increased import of estrone sulfate			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation23	Probenecid inhibits the reaction SLC22A11 protein affects the transport of estrone sulfate			[25]
Regulation Mechanism				Transcription Factor Info
DT Modulation24	Probenecid inhibits the reaction SLC22A11 protein results in increased import of estrone sulfate			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation25	SLC22A11 protein affects the transport of estrone sulfate			[25]
Regulation Mechanism				Transcription Factor Info
DT Modulation26	SLC22A11 protein results in increased import of estrone sulfate			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation27	SLC22A11 protein results in increased uptake of estrone sulfate			[39]
Regulation Mechanism				Transcription Factor Info
DT Modulation28	SLC22A11 results in increased uptake of estrone sulfate			[27]
Regulation Mechanism				Transcription Factor Info
DT Modulation29	Sulfobromophthalein inhibits the reaction SLC22A11 protein affects the transport of estrone sulfate			[25]
Regulation Mechanism				Transcription Factor Info
DT Modulation30	Uric Acid inhibits the reaction SLC22A11 protein results in increased uptake of estrone sulfate			[39]
Regulation Mechanism				Transcription Factor Info
finrozole	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	finrozole inhibits the reaction Aflatoxin B1 results in increased expression of SLC22A11 mRNA			[30]
Regulation Mechanism				Transcription Factor Info
glutaric acid	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	glutaric acid promotes the reaction SLC22A11 protein results in increased import of 6-carboxyfluorescein			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	glutaric acid promotes the reaction SLC22A11 protein results in increased import of estrone sulfate			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	glutaric acid promotes the reaction SLC22A11 protein results in increased import of perfluorooctanoic acid			[26]
Regulation Mechanism				Transcription Factor Info
Indocyanine Green	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Indocyanine Green inhibits the reaction SLC22A11 protein results in increased uptake of Thyroxine			[35]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Indocyanine Green results in decreased activity of SLC22A11 protein			[35]
Regulation Mechanism				Transcription Factor Info
lesinurad	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	lesinurad inhibits the reaction SLC22A11 protein results in increased uptake of Thyroxine			[35]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	lesinurad results in decreased activity of SLC22A11 protein			[35]
Regulation Mechanism				Transcription Factor Info
Methapyrilene	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Methapyrilene results in decreased methylation of SLC22A11 intron			[29]
Regulation Mechanism				Transcription Factor Info
mivebresib	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	mivebresib results in decreased expression of SLC22A11 mRNA			[40]
Regulation Mechanism				Transcription Factor Info
naphthyl sulfate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	naphthyl sulfate inhibits the reaction SLC22A11 protein affects the transport of estrone sulfate			[25]
Regulation Mechanism				Transcription Factor Info
Okadaic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Okadaic Acid results in increased expression of SLC22A11 mRNA			[41]
Regulation Mechanism				Transcription Factor Info
Oxypurinol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Oxypurinol inhibits the reaction SLC22A11 protein results in increased uptake of estrone sulfate			[39]
Regulation Mechanism				Transcription Factor Info
p-Aminohippuric Acid	6 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	aristolochic acid I promotes the reaction SLC22A11 results in increased export of p-Aminohippuric Acid			[27]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	estrone sulfate promotes the reaction SLC22A11 results in increased export of p-Aminohippuric Acid			[27]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	p-Aminohippuric Acid promotes the reaction SLC22A11 protein results in increased import of 6-carboxyfluorescein			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	p-Aminohippuric Acid promotes the reaction SLC22A11 protein results in increased import of estrone sulfate			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	p-Aminohippuric Acid promotes the reaction SLC22A11 protein results in increased import of perfluorooctanoic acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	SLC22A11 results in increased export of p-Aminohippuric Acid			[27]
Regulation Mechanism				Transcription Factor Info
Pentachlorophenol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Pentachlorophenol inhibits the reaction SLC22A11 protein results in increased uptake of Thyroxine			[35]
Regulation Mechanism				Transcription Factor Info
perfluorodecanoic acid	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	perfluorodecanoic acid inhibits the reaction SLC22A11 protein results in increased import of estrone sulfate			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	SLC22A11 protein results in increased transport of perfluorodecanoic acid			[42]
Regulation Mechanism				Transcription Factor Info
perfluorohexanesulfonic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLC22A11 protein results in increased transport of perfluorohexanesulfonic acid			[42]
Regulation Mechanism				Transcription Factor Info
perfluorohexanoic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLC22A11 protein affects the uptake of perfluorohexanoic acid			[43]
Regulation Mechanism				Transcription Factor Info
perfluoro-n-heptanoic acid	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	perfluoro-n-heptanoic acid inhibits the reaction SLC22A11 protein results in increased import of estrone sulfate			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	SLC22A11 protein results in increased transport of perfluoro-n-heptanoic acid			[42]
Regulation Mechanism				Transcription Factor Info
perfluorooctane sulfonic acid	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	perfluorooctane sulfonic acid inhibits the reaction SLC22A11 protein results in increased uptake of Thyroxine			[35]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	perfluorooctane sulfonic acid results in decreased activity of SLC22A11 protein			[35]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	SLC22A11 protein results in increased transport of perfluorooctane sulfonic acid			[42]
Regulation Mechanism				Transcription Factor Info
perfluorooctanoic acid	9 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	glutaric acid promotes the reaction SLC22A11 protein results in increased import of perfluorooctanoic acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	p-Aminohippuric Acid promotes the reaction SLC22A11 protein results in increased import of perfluorooctanoic acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	perfluorooctanoic acid inhibits the reaction SLC22A11 protein results in increased import of estrone sulfate			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	perfluorooctanoic acid inhibits the reaction SLC22A11 protein results in increased uptake of Thyroxine			[35]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	perfluorooctanoic acid results in decreased activity of SLC22A11 protein			[35]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Probenecid inhibits the reaction SLC22A11 protein results in increased import of perfluorooctanoic acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	SLC22A11 protein results in increased import of perfluorooctanoic acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	SLC22A11 protein results in increased transport of perfluorooctanoic acid			[42]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	Sulfobromophthalein inhibits the reaction SLC22A11 protein results in increased import of perfluorooctanoic acid			[26]
Regulation Mechanism				Transcription Factor Info
quinocetone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	quinocetone results in increased expression of SLC22A11 mRNA			[45]
Regulation Mechanism				Transcription Factor Info
Rifampin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Rifampin inhibits the reaction SLC22A11 protein results in increased uptake of Thyroxine			[35]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Rifampin results in decreased activity of SLC22A11 protein			[35]
Regulation Mechanism				Transcription Factor Info
Sodium Selenite	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sodium Selenite results in decreased expression of SLC22A11 mRNA			[46]
Regulation Mechanism				Transcription Factor Info
Sulfobromophthalein	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sulfobromophthalein inhibits the reaction SLC22A11 protein affects the transport of estrone sulfate			[25]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Sulfobromophthalein inhibits the reaction SLC22A11 protein results in increased import of perfluorooctanoic acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Sulfobromophthalein inhibits the reaction SLC22A11 protein results in increased uptake of Thyroxine			[35]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Sulfobromophthalein results in decreased activity of SLC22A11 protein			[35]
Regulation Mechanism				Transcription Factor Info
Sulpiride	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sulpiride inhibits the reaction SLC22A11 protein results in increased uptake of 6-carboxyfluorescein			[16]
Regulation Mechanism				Transcription Factor Info
tetrabromobisphenol A	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	tetrabromobisphenol A inhibits the reaction SLC22A11 protein results in increased uptake of Thyroxine			[35]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	tetrabromobisphenol A results in decreased activity of SLC22A11 protein			[35]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	tetrabromobisphenol A results in increased expression of SLC22A11 protein			[22]
Regulation Mechanism				Transcription Factor Info
theaflavin-3,3'-digallate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	theaflavin-3,3'-digallate affects the expression of SLC22A11 mRNA			[47]
Regulation Mechanism				Transcription Factor Info
Thyroxine	16 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	bisphenol AF inhibits the reaction SLC22A11 protein results in increased uptake of Thyroxine			[35]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	bisphenol F inhibits the reaction SLC22A11 protein results in increased uptake of Thyroxine			[35]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Diclofenac inhibits the reaction SLC22A11 protein results in increased uptake of Thyroxine			[35]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Indocyanine Green inhibits the reaction SLC22A11 protein results in increased uptake of Thyroxine			[35]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	lesinurad inhibits the reaction SLC22A11 protein results in increased uptake of Thyroxine			[35]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Pentachlorophenol inhibits the reaction SLC22A11 protein results in increased uptake of Thyroxine			[35]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	perfluorooctane sulfonic acid inhibits the reaction SLC22A11 protein results in increased uptake of Thyroxine			[35]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	perfluorooctanoic acid inhibits the reaction SLC22A11 protein results in increased uptake of Thyroxine			[35]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	Probenecid inhibits the reaction SLC22A11 protein results in increased uptake of Thyroxine			[35]
Regulation Mechanism				Transcription Factor Info
DT Modulation10	Quercetin inhibits the reaction SLC22A11 protein results in increased uptake of Thyroxine			[35]
Regulation Mechanism				Transcription Factor Info
DT Modulation11	Rifampin inhibits the reaction SLC22A11 protein results in increased uptake of Thyroxine			[35]
Regulation Mechanism				Transcription Factor Info
DT Modulation12	SLC22A11 protein results in increased uptake of Thyroxine			[35]
Regulation Mechanism				Transcription Factor Info
DT Modulation13	Sulfobromophthalein inhibits the reaction SLC22A11 protein results in increased uptake of Thyroxine			[35]
Regulation Mechanism				Transcription Factor Info
DT Modulation14	tetrabromobisphenol A inhibits the reaction SLC22A11 protein results in increased uptake of Thyroxine			[35]
Regulation Mechanism				Transcription Factor Info
DT Modulation15	Triclosan inhibits the reaction SLC22A11 protein results in increased uptake of Thyroxine			[35]
Regulation Mechanism				Transcription Factor Info
DT Modulation16	Verapamil inhibits the reaction SLC22A11 protein results in increased uptake of Thyroxine			[35]
Regulation Mechanism				Transcription Factor Info
Triclosan	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Triclosan inhibits the reaction SLC22A11 protein results in increased uptake of Thyroxine			[35]
Regulation Mechanism				Transcription Factor Info
tris(2-butoxyethyl) phosphate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	tris(2-butoxyethyl) phosphate affects the expression of SLC22A11 mRNA			[48]
Regulation Mechanism				Transcription Factor Info
Uric Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Uric Acid inhibits the reaction SLC22A11 protein results in increased uptake of estrone sulfate			[39]
Regulation Mechanism				Transcription Factor Info
Verapamil	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Verapamil inhibits the reaction SLC22A11 protein results in increased uptake of Thyroxine			[35]
Regulation Mechanism				Transcription Factor Info
Nanoparticle
perfluoro-n-nonanoic acid	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	perfluoro-n-nonanoic acid inhibits the reaction SLC22A11 protein results in increased import of estrone sulfate			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	SLC22A11 protein results in increased transport of perfluoro-n-nonanoic acid			[42]
Regulation Mechanism				Transcription Factor Info
Approved Drug
Probenecid	12 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Probenecid inhibits the transportation of Ochratoxin A by SLC22A11 (Ki = 44.4 microM)			[1]
Affected Drug/Substrate	Ochratoxin A	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT4
DT Modulation2	Probenecid inhibits the transportation of Prostaglandin F2alpha by SLC22A11 (Ki = 54.9 microM)			[2]
Affected Drug/Substrate	Prostaglandin F2alpha	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT4
DT Modulation3	Probenecid inhibits the transportation of Estrone sulfate by SLC22A11			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OAT4
Candesartan	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Candesartan inhibits the transportation of Uric acid by SLC22A11 (IC50 = 60 microM)			[3]
Affected Drug/Substrate	Uric acid	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OAT4
DT Modulation2	Candesartan inhibits the activity of SLC22A11 (Ki = 88.9 microM)			[4]
Cell System	Human embryonic kidney 293 cells (HEK293)-OAT4
DT Modulation3	Candesartan inhibits the activity of SLC22A11			[4]
Piroxicam	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Piroxicam inhibits the transportation of Estrone sulfate by SLC22A11 (IC50 = 84.9 microM)			[6]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT4
DT Modulation2	Piroxicam inhibits the transportation of Ochratoxin A by SLC22A11 (Ki = 107.8 microM)			[1]
Affected Drug/Substrate	Ochratoxin A	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT4
Losartan	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Losartan inhibits the transportation of Uric acid by SLC22A11 (IC50 = 18 microM)			[3]
Affected Drug/Substrate	Uric acid	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OAT4
DT Modulation2	Losartan inhibits the activity of SLC22A11 (Ki = 24.8 microM)			[4]
Cell System	Human embryonic kidney 293 cells (HEK293)-OAT4
Valsartan	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Valsartan inhibits the transportation of Uric acid by SLC22A11 (IC50 = 26 microM)			[3]
Affected Drug/Substrate	Uric acid	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OAT4
DT Modulation2	Valsartan inhibits the activity of SLC22A11 (Ki = 19.6 microM)			[4]
Cell System	Human embryonic kidney 293 cells (HEK293)-OAT4
Acetazolamide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Acetazolamide inhibits the transportation of Estrone sulfate by SLC22A11 (IC50 = 425 microM)			[7]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT4
Bumetanide	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Bumetanide inhibits the transportation of Estrone sulfate by SLC22A11 (IC50 = 348 microM)			[7]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT4
Chlorothiazide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Chlorothiazide inhibits the transportation of Estrone sulfate by SLC22A11 (IC50 = 2632 microM)			[7]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT4
Ethacrynic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ethacrynic acid inhibits the transportation of Estrone sulfate by SLC22A11 (IC50 = 8.76 microM)			[7]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT4
Furosemide	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Furosemide inhibits the transportation of Estrone sulfate by SLC22A11 (IC50 = 44.5 microM)			[7]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT4
Trichlormethiazide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Trichloromethiazide inhibits the transportation of Estrone sulfate by SLC22A11 (IC50 = 1505 microM)			[7]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT4
Novobiocin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Novobiocin inhibits the transportation of Estrone sulfate by SLC22A11 (IC50 = 92.68 microM; Ki = 90.5 microM)			[8]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Monkey kidney tissue Fibroblast-like cell lines (COS)7-OAT4
Diclofenac	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Diclofenac inhibits the transportation of Estrone sulfate by SLC22A11 (IC50 = 34.5 microM)			[6]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT4
Ibuprofen	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ibuprofen inhibits the transportation of Estrone sulfate by SLC22A11 (IC50 = 103 microM)			[6]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT4
DT Modulation2	Ibuprofen inhibits the reaction SLC22A11 protein affects the transport of estrone sulfate			[25]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Ibuprofen results in decreased activity of SLC22A11 protein			[6]
Regulation Mechanism				Transcription Factor Info
Indomethacin	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Indomethacin inhibits the transportation of Estrone sulfate by SLC22A11 (IC50 = 10.1 microM)			[6]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT4
Ketoprofen	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ketoprofen inhibits the transportation of Estrone sulfate by SLC22A11 (IC50 = 70.3 microM)			[6]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT4
Mefenamic Acid	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Mefenamic acid inhibits the transportation of Estrone sulfate by SLC22A11 (IC50 = 61.7 microM)			[6]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT4
Naproxen	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Naproxen inhibits the transportation of Estrone sulfate by SLC22A11 (IC50 = 85.4 microM)			[6]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT4
Sulindac	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sulindac inhibits the transportation of Estrone sulfate by SLC22A11 (IC50 = 617 microM)			[6]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT4
Betamipron	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Betamipron inhibits the transportation of Prostaglandin F2alpha by SLC22A11 (Ki = 502 microM)			[2]
Affected Drug/Substrate	Prostaglandin F2alpha	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT4
Cefamandole	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cefamandole inhibits the transportation of Prostaglandin F2alpha by SLC22A11 (Ki = 1140 microM)			[10]
Affected Drug/Substrate	Prostaglandin F2alpha	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT4
Cefazolin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cefazolin inhibits the transportation of Prostaglandin F2alpha by SLC22A11 (Ki = 1740 microM)			[10]
Affected Drug/Substrate	Prostaglandin F2alpha	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT4
Cefoperazone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cefoperazone inhibits the transportation of Prostaglandin F2alpha by SLC22A11 (Ki = 2800 microM)			[10]
Affected Drug/Substrate	Prostaglandin F2alpha	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT4
Cefotaxime	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cefotaxime inhibits the transportation of Prostaglandin F2alpha by SLC22A11 (Ki = 6150 microM)			[10]
Affected Drug/Substrate	Prostaglandin F2alpha	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT4
Ceftriaxone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ceftriaxone inhibits the transportation of Prostaglandin F2alpha by SLC22A11 (Ki = 2380 microM)			[10]
Affected Drug/Substrate	Prostaglandin F2alpha	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT4
Cephalothin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cephalothin inhibits the transportation of Prostaglandin F2alpha by SLC22A11 (Ki = 200 microM)			[10]
Affected Drug/Substrate	Prostaglandin F2alpha	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT4
Olmesartan medoxomil	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Olmesartan medoxomil inhibits the transportation of Uric acid by SLC22A11 (IC50 = 4.4 microM)			[3]
Affected Drug/Substrate	Uric acid	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OAT4
Telmisartan	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Telmisartan inhibits the transportation of Uric acid by SLC22A11 (IC50 = 1.2 microM)			[3]
Affected Drug/Substrate	Uric acid	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OAT4
Candesartan cilexetil	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Candesartan cilexetil inhibits the activity of SLC22A11 (Ki = 135.2 microM)			[4]
Cell System	Human embryonic kidney 293 cells (HEK293)-OAT4
Zidovudine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Zidovudine inhibits the transportation of Estrone sulfate by SLC22A11			[11]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT4
Linagliptin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Linagliptin inhibits the transportation of Estrone sulfate by SLC22A11			[5]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OAT4
Phenylbutazone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Phenylbutazone inhibits the transportation of Methotrexate by SLC22A11			[12]
Affected Drug/Substrate	Methotrexate	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT4
Acetaminophen	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Acetaminophen inhibits the activity of SLC22A11			[6]
DT Modulation2	Acetaminophen results in decreased activity of SLC22A11 protein			[6]
Regulation Mechanism				Transcription Factor Info
Aspirin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Aspirin inhibits the activity of SLC22A11			[6]
DT Modulation2	Aspirin results in decreased activity of SLC22A11 protein			[6]
Regulation Mechanism				Transcription Factor Info
Troglitazone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Troglitazone increases the expression of SLC22A11			[14]
Calcitriol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Calcitriol inhibits the expression of SLC22A11			[15]
Decitabine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Decitabine increases the expression of SLC22A11			[16]
Pranlukast	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Pranlukast inhibits the activity of SLC22A11			[4]
Lesinurad	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Lesinurad inhibits the activity of SLC22A11			[17]
Cabazitaxel	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cabazitaxel inhibits the activity of SLC22A11			[18]
Drug in Phase 2/3 Trial
Salicylic Acid	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Salicylic Acid inhibits the activity of SLC22A11			[6]
Drug in Phase 3 Trial
KW-3902	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	KW-3902 inhibits the transportation of Prostaglandin F2alpha by SLC22A11 (Ki = 20.7 microM)			[2]
Affected Drug/Substrate	Prostaglandin F2alpha	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT4
Pratosartan	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Pratosartan inhibits the transportation of Uric acid by SLC22A11 (IC50 = 31 microM)			[3]
Affected Drug/Substrate	Uric acid	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OAT4
Benzylpenicillin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Benzylpenicillin inhibits the transportation of Methotrexate by SLC22A11			[12]
Affected Drug/Substrate	Methotrexate	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT4
Drug in Phase 2 Trial
Bisphenol A	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Bisphenol A inhibits the expression of SLC22A11			[22]
Drug in Phase 1/2 Trial
PRI-724	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	PRI-724 markedly inhibits the activity of SLC22A11			[19]
Cell System	Human embryonic kidney 293 cells (HEK293)-
Investigative Drug
Beta-naphthoflavone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Beta-naphthoflavone inhibits the expression of SLC22A11			[24]
21H7	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	21H7 inhibits the activity of SLC22A11			[19]
Cell System	Human embryonic kidney 293 cells (HEK293)-
FH535	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	FH535 inhibits the activity of SLC22A11			[19]
Cell System	Human embryonic kidney 293 cells (HEK293)-
Drug Withdrawn
Cephaloridine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cephaloridine inhibits the transportation of Prostaglandin F2alpha by SLC22A11 (Ki = 3630 microM)			[10]
Affected Drug/Substrate	Prostaglandin F2alpha	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT4
Phenacetin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Phenacetin inhibits the activity of SLC22A11			[6]
Natural Product
Cigarette smoke condensate (0.32mg/ml)	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cigarette smoke condensate (0.32mg/ml) inhibits the activity of SLC22A11			[13]
Cell System	Human embryonic kidney 293 cells (HEK293)-OAT4
Quercetin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Quercetin inhibits the reaction SLC22A11 protein results in increased uptake of Thyroxine			[35]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Quercetin results in decreased activity of SLC22A11 protein			[35]
Regulation Mechanism				Transcription Factor Info
Environmental toxicant
Tetrabromobisphenol A	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tetrabromobisphenol A increases the expression of SLC22A11			[22]
Mycotoxins
Aflatoxin B1	5 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Aflatoxin B1 inhibits the transportation of Organic anion by SLC22A11 (IC50 > 1000 microM)			[9]
Affected Drug/Substrate	Organic anion	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT4
DT Modulation2	Aflatoxin B1 results in decreased methylation of SLC22A11 intron			[29]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Aflatoxin B1 results in increased expression of SLC22A11 mRNA			[30]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Aflatoxin B1 results in increased methylation of SLC22A11 gene			[31]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	finrozole inhibits the reaction Aflatoxin B1 results in increased expression of SLC22A11 mRNA			[30]
Regulation Mechanism				Transcription Factor Info
Alpha-zearalenol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Alpha-zearalenol inhibits the transportation of Organic anion by SLC22A11 (IC50 = 130 microM)			[9]
Affected Drug/Substrate	Organic anion	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT4
Citrioveridine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Citrioveridine inhibits the transportation of Organic anion by SLC22A11 (IC50 = 823 microM)			[9]
Affected Drug/Substrate	Organic anion	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT4
Cyclopiazonic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cyclopiazonic acid inhibits the transportation of Organic anion by SLC22A11 (IC50 = 86.6 microM)			[9]
Affected Drug/Substrate	Organic anion	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT4
Fumonisin B1	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Fumonisin B1 inhibits the transportation of Organic anion by SLC22A11 (IC50 > 1000 microM)			[9]
Affected Drug/Substrate	Organic anion	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT4
Patulin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Patulin inhibits the transportation of Organic anion by SLC22A11 (IC50 > 1000 microM)			[9]
Affected Drug/Substrate	Organic anion	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT4
Gliotoxin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Gliotoxin inhibits the transportation of Organic anion by SLC22A11 (IC50 > 1000 microM)			[9]
Affected Drug/Substrate	Organic anion	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT4
Zearalenone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Zearalenone inhibits the transportation of Organic anion by SLC22A11 (IC50 = 103 microM)			[9]
Affected Drug/Substrate	Organic anion	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT4
ochratoxin A	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLC22A11 protein affects the transport of ochratoxin A			[25]
Regulation Mechanism				Transcription Factor Info
Carcinogen
Benzo(a)pyrene	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Benzo(a)pyrene increases the expression of SLC22A11			[23]
Arsenic	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Arsenic affects the methylation of SLC22A11 gene			[32]
Regulation Mechanism				Transcription Factor Info
Health and Environmental Toxicant
Lead	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Lead increases the expression of SLC22A11			[20]
Butyraldehyde	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Butyraldehyde inhibits the expression of SLC22A11			[21]

References
1	Role of human organic anion transporter 4 in the transport of ochratoxin A. Biochim Biophys Acta. 2002 Jun 12;1590(1-3):64-75.
2	Interaction of human organic anion transporters 2 and 4 with organic anion transport inhibitors. J Pharmacol Exp Ther. 2002 Jun;301(3):797-802.
3	Involvement of uric acid transporters in alteration of serum uric acid level by angiotensin II receptor blockers. Pharm Res. 2008 Mar;25(3):639-46.
4	Inhibitory effects of angiotensin II receptor antagonists and leukotriene receptor antagonists on the transport of human organic anion transporter 4. J Pharm Pharmacol. 2006 Nov;58(11):1499-505.
5	Evaluation and prediction of potential drug-drug interactions of linagliptin using in vitro cell culture methods. Drug Metab Dispos. 2013 Jan;41(1):149-58.
6	Interactions of human organic anion transporters and human organic cation transporters with nonsteroidal anti-inflammatory drugs. J Pharmacol Exp Ther. 2002 Nov;303(2):534-9.
7	Interactions of human organic anion transporters with diuretics. J Pharmacol Exp Ther. 2004 Mar;308(3):1021-9.
8	Novobiocin is a potent inhibitor for human organic anion transporters. Drug Metab Dispos. 2009 Jun;37(6):1203-10.
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