Detail Information of Exogenous Modulation

General Information of Drug Transporter (DT)
DT ID DTD0017 Transporter Info
Gene Name ABCC6
Transporter Name Multidrug resistance-associated protein 6
Gene ID
368
UniProt ID
O95255
Exogenous factors (drugs, dietary constituents, etc.) Modulation of This DT (EGM)

Chemical Compound

  DT Modulation1

 Benzbromarone inhibits the reaction ABCC6 protein affects the transport of N-ethylmaleimide-S-glutathione [1]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation2

 Benzbromarone results in decreased activity of ABCC6 protein [3]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation1

 Indomethacin inhibits the reaction ABCC6 protein affects the transport of N-ethylmaleimide-S-glutathione [1]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation2

 Indomethacin results in decreased activity of ABCC6 protein [3]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation1

 Probenecid inhibits the reaction ABCC6 protein affects the transport of N-ethylmaleimide-S-glutathione [1]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation1

 Phenobarbital results in increased expression of ABCC6 protein [44]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation1

 Verapamil results in decreased activity of ABCC6 protein [3]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation1

 ABCC6 protein affects the susceptibility to Fluorouracil [4]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation1

 RARA protein promotes the reaction Alitretinoin results in increased expression of ABCC6 mRNA [5]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation1

 Valproic Acid results in increased expression of ABCC6 mRNA [24]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation1

 Benzo(a)pyrene affects the methylation of ABCC6 intron [35]

Regulation Mechanism

 Transcription Factor Info

  7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of ABCC6 mRNA [33]

Regulation Mechanism

 Transcription Factor Info

  9,10-Dimethyl-1,2-benzanthracene

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 ABCC6 gene SNP affects the susceptibility to 9,10-Dimethyl-1,2-benzanthracene [34]

Regulation Mechanism

 Transcription Factor Info

  Adenosine Triphosphate

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Adenosine Triphosphate binds to ABCC6 protein [1]

Regulation Mechanism

 Transcription Factor Info

  belinostat

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 belinostat results in decreased expression of ABCC6 mRNA [12]

Regulation Mechanism

 Transcription Factor Info

  bisphenol A

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 bisphenol A affects the expression of ABCC6 mRNA [29]

Regulation Mechanism

 Transcription Factor Info

  bisphenol S

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 bisphenol S results in decreased methylation of ABCC6 gene [36]

Regulation Mechanism

 Transcription Factor Info

  butyraldehyde

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 butyraldehyde results in decreased expression of ABCC6 mRNA [25]

Regulation Mechanism

 Transcription Factor Info

  calcein AM

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Glutathione promotes the reaction ABCC6 protein affects the transport of calcein AM [37]

Regulation Mechanism

 Transcription Factor Info

  diallyl disulfide

            2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 diallyl disulfide results in decreased expression of ABCC6 mRNA [23]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation2

 diallyl disulfide results in increased expression of ABCC6 mRNA [23]

Regulation Mechanism

 Transcription Factor Info

  diallyl trisulfide

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 diallyl trisulfide results in increased expression of ABCC6 mRNA [23]

Regulation Mechanism

 Transcription Factor Info

  di-n-butylphosphoric acid

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 di-n-butylphosphoric acid affects the expression of ABCC6 mRNA [38]

Regulation Mechanism

 Transcription Factor Info

  Docetaxel

            2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 ABCC6 gene SNP affects the susceptibility to Docetaxel [39]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation2

 Docetaxel results in decreased susceptibility to Docetaxel which affects the expression of ABCC6 mRNA [40]

Regulation Mechanism

 Transcription Factor Info

  fluorexon

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 ABCC6 affects the transport of fluorexon [3]

Regulation Mechanism

 Transcription Factor Info

  Glutathione

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Glutathione promotes the reaction ABCC6 protein affects the transport of calcein AM [37]

Regulation Mechanism

 Transcription Factor Info

  heliotrine

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 heliotrine results in decreased expression of ABCC6 mRNA [26]

Regulation Mechanism

 Transcription Factor Info

  Leukotriene C4

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 ABCC6 protein affects the transport of Leukotriene C4 [1]

Regulation Mechanism

 Transcription Factor Info

  methyleugenol

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 methyleugenol results in decreased expression of ABCC6 mRNA [31]

Regulation Mechanism

 Transcription Factor Info

  methylmercuric chloride

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 methylmercuric chloride results in decreased expression of ABCC6 mRNA [41]

Regulation Mechanism

 Transcription Factor Info

  N-ethylmaleimide-S-glutathione

            4 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 ABCC6 protein affects the transport of N-ethylmaleimide-S-glutathione [1]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation2

 Benzbromarone inhibits the reaction ABCC6 protein affects the transport of N-ethylmaleimide-S-glutathione [1]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation3

 Indomethacin inhibits the reaction ABCC6 protein affects the transport of N-ethylmaleimide-S-glutathione [1]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation4

 Probenecid inhibits the reaction ABCC6 protein affects the transport of N-ethylmaleimide-S-glutathione [1]

Regulation Mechanism

 Transcription Factor Info

  N-Nitrosopyrrolidine

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 N-Nitrosopyrrolidine results in decreased expression of ABCC6 mRNA [31]

Regulation Mechanism

 Transcription Factor Info

  Okadaic Acid

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Okadaic Acid results in decreased expression of ABCC6 mRNA [43]

Regulation Mechanism

 Transcription Factor Info

  propionaldehyde

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 propionaldehyde results in decreased expression of ABCC6 mRNA [25]

Regulation Mechanism

 Transcription Factor Info

  senecionine

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 senecionine results in decreased expression of ABCC6 mRNA [26]

Regulation Mechanism

 Transcription Factor Info

  senkirkine

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 senkirkine results in decreased expression of ABCC6 mRNA [26]

Regulation Mechanism

 Transcription Factor Info

  Silicon Dioxide

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Silicon Dioxide analog results in decreased expression of ABCC6 mRNA [45]

Regulation Mechanism

 Transcription Factor Info

  S-Nitrosoglutathione

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 S-Nitrosoglutathione results in increased expression of ABCC6 mRNA [46]

Regulation Mechanism

 Transcription Factor Info

  sodium arsenite

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 sodium arsenite results in decreased expression of ABCC6 mRNA [27]

Regulation Mechanism

 Transcription Factor Info

  trichostatin A

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 trichostatin A results in decreased expression of ABCC6 mRNA [24]

Regulation Mechanism

 Transcription Factor Info

  triphenyl phosphate

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 triphenyl phosphate affects the expression of ABCC6 mRNA [38]

Regulation Mechanism

 Transcription Factor Info

  Vincristine

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Vincristine results in decreased susceptibility to Vincristine which results in decreased expression of ABCC6 mRNA [40]

Regulation Mechanism

 Transcription Factor Info

Approved Drug

  Benzbromarone

            3 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Benzbromarone inhibits the transportation of N-ethylmaleimide S-glutathione by ABCC6 [1]

Affected Drug/Substrate

 N-ethylmaleimide S-glutathione Modulation Type Inhibition

Cell System

 Spodoptera frugiperda (Sf9) cells-MRP6

  Indomethacin

            3 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Indomethacin inhibits the transportation of N-ethylmaleimide S-glutathione by ABCC6 [1]

Affected Drug/Substrate

 N-ethylmaleimide S-glutathione Modulation Type Inhibition

Cell System

 Spodoptera frugiperda (Sf9) cells-MRP6

  Probenecid

            2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Probenecid inhibits the transportation of N-ethylmaleimide S-glutathione by ABCC6 [1]

Affected Drug/Substrate

 N-ethylmaleimide S-glutathione Modulation Type Inhibition

Cell System

 Spodoptera frugiperda (Sf9) cells-MRP6

  Phenobarbital

            2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Phenobarbital inhibits the expression of ABCC6 [2]

Regulation Mechanism

 via modulation of Nuclear receptor subfamily 1 group I member 3 (NR1I3) Transcription Factor Info

Cell System

 Human primary human hepatocytes

  Verapamil

            2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Verapamil inhibits the activity of ABCC6 [3]

  Fluorouracil

            2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Fluorouracil increases the expression of ABCC6 [4]

  Alitretinoin

            2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Alitretinoin increases the expression of ABCC6 [5]

  Tretinoin

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Tretinoin increases the expression of ABCC6 [5]

  Progesterone

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Progesterone inhibits the expression of ABCC6 [6]

  Copper Sulfate

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Copper Sulfate inhibits the expression of ABCC6 [7]

  Estradiol

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Estradiol inhibits the expression of ABCC6 [8]

  Zidovudine

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Zidovudine increases the expression of ABCC6 [9]

  Methamphetamine

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Methamphetamine inhibits the expression of ABCC6 [10]

  Rosiglitazone

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Rosiglitazone inhibits the expression of ABCC6 [11]

  Troglitazone

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Troglitazone inhibits the expression of ABCC6 [11]

  Belinostat

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Belinostat inhibits the expression of ABCC6 [12]

  Rifampin

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Rifampin increases the expression of ABCC6 [13]

  Urethane

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Urethane inhibits the expression of ABCC6 [14]

  Valproic Acid

            2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Valproic Acid inhibits the expression of ABCC6 [15]

  Doxorubicin

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Doxorubicin inhibits the expression of ABCC6 [16]

  Sunitinib

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Sunitinib inhibits the expression of ABCC6 [17]

  Cyclosporine

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Cyclosporine inhibits the expression of ABCC6 [18]

  Acetaminophen

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Acetaminophen inhibits the expression of ABCC6 [19]

  Micafungin

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Micafungin inhibits the activity of ABCC6 [20]

Drug in Phase 3 Trial

  Triclosan

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Triclosan inhibits the expression of ABCC6 [28]

Drug in Phase 2 Trial

  Bisphenol A

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Bisphenol A affects the expression of ABCC6 [29]

Drug in Phase 1 Trial

  Quercetin

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Quercetin increases the expression of ABCC6 [21]

  Trichostatin A

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Trichostatin A inhibits the expression of ABCC6 [24]

  Sodium arsenite

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Sodium arsenite inhibits the expression of ABCC6 [27]

Patented Pharmaceutical Agent

  HSDB-595

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 HSDB-595 inhibits the expression of ABCC6 [23]

Natural Product

  Heliotrine

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Heliotrine inhibits the expression of ABCC6 [26]

  Senecionine

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Senecionine inhibits the expression of ABCC6 [26]

  Methyleugenol

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Methyleugenol inhibits the expression of ABCC6 [31]

  Tobacco Smoke Pollution

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Tobacco Smoke Pollution inhibits the expression of ABCC6 [32]

Mycotoxins

  Aflatoxin B1

            3 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Aflatoxin B1 inhibits the expression of ABCC6 [22]

  DT Modulation2

 Aflatoxin B1 affects the expression of ABCC6 protein [8]

Regulation Mechanism

 Transcription Factor Info

  DT Modulation3

 Aflatoxin B1 results in increased methylation of ABCC6 polyA tail [35]

Regulation Mechanism

 Transcription Factor Info

Carcinogen

  Benzo(a)pyrene

            2 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Benzo(a)pyrene inhibits the expression of ABCC6 [31]

  Nickel

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Nickel results in decreased expression of ABCC6 mRNA [42]

Regulation Mechanism

 Transcription Factor Info

Health and Environmental Toxicant

  Butyraldehyde

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Butyraldehyde inhibits the expression of ABCC6 [25]

  Diethylhexyl Phthalate

            1 DT Activity Modulations Related to This Exogenous Factor Click to Show/Hide the Full List

  DT Modulation1

 Diethylhexyl Phthalate inhibits the expression of ABCC6 [30]
References
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3 Multidrug resistance protein-6 (MRP6) in human dermal fibroblasts. Comparison between cells from normal subjects and from Pseudoxanthoma elasticum patients. Matrix Biol. 2003 Nov;22(6):491-500.
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41 Stem Cell Transcriptome Responses and Corresponding Biomarkers That Indicate the Transition from Adaptive Responses to Cytotoxicity. Chem Res Toxicol. 2017 Apr 17;30(4):905-922.
42 Patients with atopic dermatitis have attenuated and distinct contact hypersensitivity responses to common allergens in skin. J Allergy Clin Immunol. 2015;135(3):712-20.
43 A multi-omics approach to elucidate okadaic acid-induced changes in human HepaRG hepatocarcinoma cells. Arch Toxicol. 2024;98(9):2919-2935.
44 Proteomic analysis of hepatic effects of phenobarbital in mice with humanized liver. Arch Toxicol. 2022 Oct;96(10):2739-2754.
45 High-throughput, quantitative assessment of the effects of low-dose silica nanoparticles on lung cells: grasping complex toxicity with a great depth of field. BMC Genomics. 2015;16(1):315.
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