Detail Information of Exogenous Modulation

General Information of Drug Transporter (DT)
DT ID	DTD0016 Transporter Info
Gene Name	ABCC5
Transporter Name	Multidrug resistance-associated protein 5
Gene ID	10057
UniProt ID	O15440

Exogenous factors (drugs, dietary constituents, etc.) Modulation of This DT (EGM)
Chemical Compound
DT Modulation1	Probenecid inhibits the reaction ABCC5 protein results in decreased susceptibility to Thioguanine			[1]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	ABCC5 protein results in decreased susceptibility to Pemetrexed			[1]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	ABCC5 protein results in decreased susceptibility to Methotrexate			[1]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Methotrexate results in decreased expression of ABCC5 mRNA			[70]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Benzbromarone inhibits the reaction ABCC5 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein			[45]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	ABCC5 mRNA results in decreased susceptibility to Cisplatin			[59]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	ABCC5 protein results in decreased susceptibility to Cisplatin			[1]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Cisplatin co-treated with jinfukang results in increased expression of ABCC5 mRNA			[37]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Cisplatin results in increased expression of ABCC5 mRNA			[37]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Silymarin inhibits the reaction ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein			[8]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Valproic Acid affects the expression of ABCC5 mRNA			[76]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Cycloheximide co-treated with Estradiol results in decreased expression of ABCC5 mRNA			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Estradiol co-treated with Tetrachlorodibenzodioxin results in increased expression of ABCC5 mRNA			[65]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Estradiol results in increased expression of ABCC5 mRNA			[65]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	ABCC5 protein results in increased export of Zidovudine			[77]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	5-nitro-2-(3-phenylpropylamino)benzoic acid inhibits the reaction ABCC5 protein results in decreased susceptibility to Fluorouracil			[1]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	ABCC5 protein results in decreased susceptibility to Fluorouracil			[66]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	ABCC5 protein results in increased export of and results in decreased susceptibility to Fluorouracil			[1]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Cycloheximide co-treated with Estradiol results in decreased expression of ABCC5 mRNA			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Benzo(a)pyrene results in decreased methylation of ABCC5 5' UTR			[51]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Benzo(a)pyrene results in decreased methylation of ABCC5 promoter			[51]
Regulation Mechanism				Transcription Factor Info
1-Methyl-3-isobutylxanthine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S results in decreased expression of ABCC5 mRNA			[43]
Regulation Mechanism				Transcription Factor Info
2,3-bis(3'-hydroxybenzyl)butyrolactone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone results in decreased expression of ABCC5 mRNA			[44]
Regulation Mechanism				Transcription Factor Info
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of ABCC5 protein			[33]
Regulation Mechanism				Transcription Factor Info
2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein	8 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein			[8]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	daidzein inhibits the reaction ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein			[8]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	hesperetin inhibits the reaction ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein			[8]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	naringenin inhibits the reaction ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein			[8]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Quercetin inhibits the reaction ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein			[8]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Resveratrol inhibits the reaction ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein			[8]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	Silymarin inhibits the reaction ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein			[8]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	verlukast inhibits the reaction ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein			[8]
Regulation Mechanism				Transcription Factor Info
2'-deoxyuridylic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCC5 protein results in increased export of 2'-deoxyuridylic acid			[1]
Regulation Mechanism				Transcription Factor Info
5(6)-carboxy-2',7'-dichlorofluorescein	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCC5 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein			[45]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	ABCC5 protein results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein			[46]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Benzbromarone inhibits the reaction ABCC5 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein			[45]
Regulation Mechanism				Transcription Factor Info
5-fluorouridine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCC5 protein results in increased export of 5-fluorouridine			[1]
Regulation Mechanism				Transcription Factor Info
5-nitro-2-(3-phenylpropylamino)benzoic acid	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	5-nitro-2-(3-phenylpropylamino)benzoic acid inhibits the reaction ABCC5 protein results in decreased susceptibility to Fluorouracil			[1]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	5-nitro-2-(3-phenylpropylamino)benzoic acid inhibits the reaction ABCC5 protein results in decreased susceptibility to Thioguanine			[1]
Regulation Mechanism				Transcription Factor Info
abrine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	abrine results in decreased expression of ABCC5 mRNA			[47]
Regulation Mechanism				Transcription Factor Info
afimoxifene	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	afimoxifene inhibits the reaction Estrogens results in decreased expression of ABCC5 mRNA			[49]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	afimoxifene results in increased expression of ABCC5 mRNA			[9]
Regulation Mechanism				Transcription Factor Info
ammonium 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)-propanoate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ammonium 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)-propanoate results in decreased expression of ABCC5 mRNA			[40]
Regulation Mechanism				Transcription Factor Info
aristolochic acid I	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	aristolochic acid I results in decreased expression of ABCC5 mRNA			[50]
Regulation Mechanism				Transcription Factor Info
azoxystrobin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	azoxystrobin results in decreased expression of ABCC5 mRNA			[22]
Regulation Mechanism				Transcription Factor Info
benzo(e)pyrene	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	benzo(e)pyrene results in increased methylation of ABCC5 intron			[52]
Regulation Mechanism				Transcription Factor Info
beta-methylcholine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	beta-methylcholine affects the expression of ABCC5 mRNA			[16]
Regulation Mechanism				Transcription Factor Info
bisphenol A	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	bisphenol A analog results in increased expression of ABCC5 mRNA			[39]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	bisphenol A results in decreased expression of ABCC5 mRNA			[53]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	bisphenol A results in increased expression of ABCC5 mRNA			[54]
Regulation Mechanism				Transcription Factor Info
bisphenol S	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S results in decreased expression of ABCC5 mRNA			[43]
Regulation Mechanism				Transcription Factor Info
Cadmium Chloride	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cadmium Chloride results in decreased expression of ABCC5 mRNA			[55]
Regulation Mechanism				Transcription Factor Info
CGP 52608	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	CGP 52608 promotes the reaction RORA protein binds to ABCC5 gene			[56]
Regulation Mechanism				Transcription Factor Info
chromium hexavalent ion	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	chromium hexavalent ion affects the expression of ABCC5 mRNA			[57]
Regulation Mechanism				Transcription Factor Info
chrysin	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCC5 protein affects the reaction chrysin results in increased transport of Glutathione			[58]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	chrysin results in decreased expression of ABCC5 mRNA			[33]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	chrysin results in decreased expression of ABCC5 protein			[33]
Regulation Mechanism				Transcription Factor Info
coumarin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	coumarin results in decreased phosphorylation of ABCC5 protein			[60]
Regulation Mechanism				Transcription Factor Info
Coumestrol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone results in decreased expression of ABCC5 mRNA			[44]
Regulation Mechanism				Transcription Factor Info
daidzein	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	daidzein inhibits the reaction ABCC5 protein results in decreased susceptibility to Thioguanine			[8]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	daidzein inhibits the reaction ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein			[8]
Regulation Mechanism				Transcription Factor Info
deguelin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	deguelin results in decreased expression of ABCC5 mRNA			[22]
Regulation Mechanism				Transcription Factor Info
Dexamethasone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S results in decreased expression of ABCC5 mRNA			[43]
Regulation Mechanism				Transcription Factor Info
dicrotophos	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	dicrotophos results in increased expression of ABCC5 mRNA			[38]
Regulation Mechanism				Transcription Factor Info
di-n-butylphosphoric acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	di-n-butylphosphoric acid affects the expression of ABCC5 mRNA			[62]
Regulation Mechanism				Transcription Factor Info
Docetaxel	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Docetaxel results in decreased susceptibility to Docetaxel which results in increased expression of ABCC5 mRNA			[63]
Regulation Mechanism				Transcription Factor Info
Doxorubicin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCC5 protein results in decreased susceptibility to Doxorubicin			[1]
Regulation Mechanism				Transcription Factor Info
epigallocatechin gallate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	potassium chromate(VI) co-treated with epigallocatechin gallate results in decreased expression of ABCC5 mRNA			[64]
Regulation Mechanism				Transcription Factor Info
Estrogens	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	afimoxifene inhibits the reaction Estrogens results in decreased expression of ABCC5 mRNA			[49]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Estrogens results in decreased expression of ABCC5 mRNA			[49]
Regulation Mechanism				Transcription Factor Info
Fluorodeoxyuridylate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCC5 protein results in increased export of Fluorodeoxyuridylate			[1]
Regulation Mechanism				Transcription Factor Info
FR900359	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	FR900359 results in decreased phosphorylation of ABCC5 protein			[67]
Regulation Mechanism				Transcription Factor Info
Glutathione	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCC5 protein affects the reaction chrysin results in increased transport of Glutathione			[58]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	ABCC5 protein affects the transport of Glutathione analog			[68]
Regulation Mechanism				Transcription Factor Info
hesperetin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	hesperetin inhibits the reaction ABCC5 protein results in decreased susceptibility to Thioguanine			[8]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	hesperetin inhibits the reaction ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein			[8]
Regulation Mechanism				Transcription Factor Info
indeno(1,2,3-cd)pyrene	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	indeno(1,2,3-cd)pyrene results in increased expression of ABCC5 mRNA			[69]
Regulation Mechanism				Transcription Factor Info
Indomethacin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S results in decreased expression of ABCC5 mRNA			[43]
Regulation Mechanism				Transcription Factor Info
Methapyrilene	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Methapyrilene results in increased methylation of ABCC5 intron			[52]
Regulation Mechanism				Transcription Factor Info
naringenin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	naringenin inhibits the reaction ABCC5 protein results in decreased susceptibility to Thioguanine			[8]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	naringenin inhibits the reaction ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein			[8]
Regulation Mechanism				Transcription Factor Info
Okadaic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Okadaic Acid results in increased expression of ABCC5 mRNA			[71]
Regulation Mechanism				Transcription Factor Info
Oxaliplatin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCC5 protein affects the susceptibility to Oxaliplatin			[72]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	ABCC5 protein results in decreased susceptibility to Oxaliplatin			[1]
Regulation Mechanism				Transcription Factor Info
Oxygen	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Oxygen deficiency results in decreased expression of ABCC5 mRNA			[73]
Regulation Mechanism				Transcription Factor Info
Palmitic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Palmitic Acid results in decreased phosphorylation of ABCC5 protein			[74]
Regulation Mechanism				Transcription Factor Info
perfluorooctane sulfonic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	perfluorooctane sulfonic acid results in decreased expression of ABCC5 mRNA			[40]
Regulation Mechanism				Transcription Factor Info
perfluorooctanoic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	perfluorooctanoic acid results in decreased expression of ABCC5 mRNA			[40]
Regulation Mechanism				Transcription Factor Info
picene	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	picene results in increased expression of ABCC5 mRNA			[69]
Regulation Mechanism				Transcription Factor Info
picoxystrobin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	picoxystrobin results in decreased expression of ABCC5 mRNA			[22]
Regulation Mechanism				Transcription Factor Info
potassium chromate(VI)	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	potassium chromate(VI) co-treated with epigallocatechin gallate results in decreased expression of ABCC5 mRNA			[64]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	potassium chromate(VI) results in decreased expression of ABCC5 mRNA			[64]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	potassium chromate(VI) results in increased expression of ABCC5 mRNA			[75]
Regulation Mechanism				Transcription Factor Info
pyrachlostrobin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	pyrachlostrobin results in decreased expression of ABCC5 mRNA			[22]
Regulation Mechanism				Transcription Factor Info
sodium arsenite	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	sodium arsenite results in decreased expression of ABCC5 mRNA			[55]
Regulation Mechanism				Transcription Factor Info
Tetrachlorodibenzodioxin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Estradiol co-treated with Tetrachlorodibenzodioxin results in increased expression of ABCC5 mRNA			[65]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Tetrachlorodibenzodioxin results in increased expression of ABCC5 mRNA			[65]
Regulation Mechanism				Transcription Factor Info
Thioguanine	7 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	5-nitro-2-(3-phenylpropylamino)benzoic acid inhibits the reaction ABCC5 protein results in decreased susceptibility to Thioguanine			[1]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	ABCC5 protein results in decreased susceptibility to Thioguanine			[1]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	daidzein inhibits the reaction ABCC5 protein results in decreased susceptibility to Thioguanine			[8]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	hesperetin inhibits the reaction ABCC5 protein results in decreased susceptibility to Thioguanine			[8]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	naringenin inhibits the reaction ABCC5 protein results in decreased susceptibility to Thioguanine			[8]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Probenecid inhibits the reaction ABCC5 protein results in decreased susceptibility to Thioguanine			[1]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	Quercetin inhibits the reaction ABCC5 protein results in decreased susceptibility to Thioguanine			[8]
Regulation Mechanism				Transcription Factor Info
U 0126	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	U 0126 results in decreased expression of ABCC5 protein			[33]
Regulation Mechanism				Transcription Factor Info
verlukast	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	verlukast inhibits the reaction ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein			[8]
Regulation Mechanism				Transcription Factor Info
Vincristine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Vincristine results in decreased susceptibility to Vincristine which affects the expression of ABCC5 mRNA			[63]
Regulation Mechanism				Transcription Factor Info
xanthohumol	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	xanthohumol binds to and results in decreased activity of ABCC5 protein			[61]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	xanthohumol binds to and results in decreased activity of ABCC5 protein which results in decreased export of Hyaluronic Acid			[61]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	xanthohumol inhibits the reaction ABCC5 protein results in increased export of Hyaluronic Acid			[61]
Regulation Mechanism				Transcription Factor Info
Approved Drug
Probenecid	5 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Probenecid inhibits the transportation of 5-Fluorodeoxyuridine monophosphate by ABCC5 (IC50 = 70 microM)			[1]
Affected Drug/Substrate	5-Fluorodeoxyuridine monophosphate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MRP5
DT Modulation2	Probenecid inhibits the transportation of 9-(2-Phosphonomethoxyethyl)adenine by ABCC5 (IC50 = 200 microM)			[3]
Affected Drug/Substrate	9-(2-Phosphonomethoxyethyl)adenine	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MRP4
DT Modulation3	Probenecid inhibits the transportation of Carboxydichlorofluorescein by ABCC5 (IC50 = 34 microM)			[4]
Affected Drug/Substrate	Carboxydichlorofluorescein	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MRP5
DT Modulation4	Probenecid inhibits the activity of ABCC5			[4]
Sildenafil	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sildenafil inhibits the transportation of 5-Fluorodeoxyuridine monophosphate by ABCC5 (IC50 = 580 microM)			[1]
Affected Drug/Substrate	5-Fluorodeoxyuridine monophosphate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MRP5
DT Modulation2	Sildenafil inhibits the transportation of 9-(2-Phosphonomethoxyethyl)adenine by ABCC5 (IC50 = 80 microM)			[3]
Affected Drug/Substrate	9-(2-Phosphonomethoxyethyl)adenine	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MRP4
DT Modulation3	Sildenafil inhibits the transportation of Cyclic guanosine monophosphate by ABCC5 (Ki = 0.267 microM)			[5]
Affected Drug/Substrate	Cyclic guanosine monophosphate	Modulation Type	Inhibition
Cell System	Chinese hamster lung fibroblasts V79 cells (V79)-MRP5
DT Modulation4	Sildenafil inhibits the transportation of Cyclic guanosine monophosphate by ABCC5			[6]
Affected Drug/Substrate	Cyclic guanosine monophosphate	Modulation Type	Inhibition
Pemetrexed	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Pemetrexed inhibits the transportation of 5-Fluorodeoxyuridine monophosphate by ABCC5 (IC50 = 2110 microM)			[1]
Affected Drug/Substrate	5-Fluorodeoxyuridine monophosphate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MRP5
DT Modulation2	Pemetrexed inhibits the transportation of Carboxydichlorofluorescein by ABCC5 (IC50 = 442 microM)			[4]
Affected Drug/Substrate	Carboxydichlorofluorescein	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MRP5
DT Modulation3	Pemetrexed inhibits the transportation of Carboxydichlorofluorescein by ABCC5 (Ki = 300 microM)			[4]
Affected Drug/Substrate	Carboxydichlorofluorescein	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MRP5
Methotrexate	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Methotrexate inhibits the transportation of 5-Fluorodeoxyuridine monophosphate by ABCC5 (IC50 = 780 microM)			[1]
Affected Drug/Substrate	5-Fluorodeoxyuridine monophosphate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MRP5
DT Modulation2	Methotrexate inhibits the transportation of Carboxydichlorofluorescein by ABCC5 (Ki = 1059 microM)			[4]
Affected Drug/Substrate	Carboxydichlorofluorescein	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MRP5
Dipyridamole	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Dipyridamole inhibits the transportation of 9-(2-Phosphonomethoxyethyl)adenine by ABCC5 (IC50 = 30 microM)			[3]
Affected Drug/Substrate	9-(2-Phosphonomethoxyethyl)adenine	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MRP4
DT Modulation2	Dipyridamole inhibits the transportation of Cyclic guanosine monophosphate by ABCC5			[6]
Affected Drug/Substrate	Cyclic guanosine monophosphate	Modulation Type	Inhibition
Sulfinpyrazone	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sulfinpyrazone inhibits the transportation of 9-(2-Phosphonomethoxyethyl)adenine by ABCC5 (IC50 = 300 microM)			[3]
Affected Drug/Substrate	9-(2-Phosphonomethoxyethyl)adenine	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MRP4
DT Modulation2	Sulfinpyrazone inhibits the transportation of Carboxydichlorofluorescein by ABCC5 (IC50 = 103.2 microM)			[4]
Affected Drug/Substrate	Carboxydichlorofluorescein	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MRP5
Glyburide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Glibenclamide inhibits the transportation of 5-Fluorodeoxyuridine monophosphate by ABCC5 (IC50 = 15 microM)			[1]
Affected Drug/Substrate	5-Fluorodeoxyuridine monophosphate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MRP5
Benzbromarone	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Benzbromarone inhibits the transportation of 9-(2-Phosphonomethoxyethyl)adenine by ABCC5 (IC50 = 150 microM)			[3]
Affected Drug/Substrate	9-(2-Phosphonomethoxyethyl)adenine	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MRP4
Floxuridine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Floxuridine inhibits the transportation of Carboxydichlorofluorescein by ABCC5 (Ki = 1163 microM)			[4]
Affected Drug/Substrate	Carboxydichlorofluorescein	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MRP5
Cisplatin	5 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cisplatin induces the activity of ABCC5			[7]
Cell System	Human hepatocellular carcinoma cell line (HepG2)-MRP5
Rifampicin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Rifampicin induces the activity of ABCC5			[7]
Cell System	Human hepatocellular carcinoma cell line (HepG2)-MRP5
Fulvestrant	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Fulvestrant inhibits the expression of ABCC5			[9]
Acetaminophen	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Acetaminophen increases the expression of ABCC5			[10]
DT Modulation2	Acetaminophen affects the expression of ABCC5 mRNA			[48]
Regulation Mechanism				Transcription Factor Info
Celecoxib	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Celecoxib increases the expression of ABCC5			[11]
Rifampin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Rifampin increases the expression of ABCC5			[12]
Decitabine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Decitabine increases the expression of ABCC5			[13]
Arsenic Trioxide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Arsenic Trioxide increases the expression of ABCC5			[14]
Paclitaxel	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Paclitaxel increases the expression of ABCC5			[15]
Hydrogen Peroxide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Hydrogen Peroxide affects the expression of ABCC5			[16]
Aspirin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Aspirin increases the expression of ABCC5			[17]
Valproic Acid	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Valproic Acid increases the expression of ABCC5			[18]
Zoledronic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Zoledronic Acid inhibits the expression of ABCC5			[19]
Urethane	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Urethane increases the expression of ABCC5			[20]
Sunitinib	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sunitinib increases the expression of ABCC5			[21]
Estradiol	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Estradiol inhibits the expression of ABCC5			[23]
Zidovudine	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Zidovudine increases the expression of ABCC5			[24]
Gemcitabine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Gemcitabine induces the activity of ABCC5			[25]
Fluorouracil	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Fluorouracil induces the activity of ABCC5			[25], [26]
Micafungin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Micafungin inhibits the activity of ABCC5			[27]
Drug Marketed but not Approved by US FDA
Rotenone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Rotenone inhibits the expression of ABCC5			[22]
Drug in Phase 3 Trial
Curcumin	10 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Curcumin inhibits the transportation of 5-Fluorouracil by ABCC5 (IC50 = 0.5 +/- 0.1 microM)			[2]
Affected Drug/Substrate	5-Fluorouracil	Modulation Type	Inhibition
Cell System	Human pancreatic cancer cell lines (PANC-1)-MRP5
DT Modulation2	Curcumin inhibits the transportation of 5-Fluorouracil by ABCC5 (IC50 = 0.7 +/- 0.1 microM)			[2]
Affected Drug/Substrate	5-Fluorouracil	Modulation Type	Inhibition
Cell System	MiaPaCa-2 pancreatic cancer cells
DT Modulation3	Curcumin inhibits the transportation of 5-Fluorouracil by ABCC5 (IC50 = 20.1 +/- 2.2 microM)			[2]
Affected Drug/Substrate	5-Fluorouracil	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MRP5
DT Modulation4	Curcumin inhibits the transportation of 2',7'-Bis(2-carboxyethyl)-5(6)-carboxyfluorescein by ABCC5			[2]
Affected Drug/Substrate	2',7'-Bis(2-carboxyethyl)-5(6)-carboxyfluorescein	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MRP5
Afimoxifene	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Afimoxifene increases the expression of ABCC5			[9]
Drug in Phase 2 Trial
Genistein	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Genistein inhibits the expression of ABCC5			[36]
Bisphenol A	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Bisphenol A increases the expression of ABCC5			[39]
Drug in Phase 1 Trial
Dihydrotestosterone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Dihydrotestosterone affects the expression of ABCC5			[29]
LY-294002	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	LY-294002 inhibits the expression of ABCC5			[33]
Drug in Preclinical Test
(+)-JQ1	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	(+)-JQ1 increases the expression of ABCC5			[35]
Discontinued Drug
Trequinsin	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Trequinsin inhibits the transportation of 5-Fluorodeoxyuridine monophosphate by ABCC5 (IC50 = 580 microM)			[1]
Affected Drug/Substrate	5-Fluorodeoxyuridine monophosphate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MRP5
DT Modulation2	Trequinsin inhibits the transportation of 9-(2-Phosphonomethoxyethyl)adenine by ABCC5 (IC50 = 30 microM)			[3]
Affected Drug/Substrate	9-(2-Phosphonomethoxyethyl)adenine	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MRP4
DT Modulation3	Trequinsin inhibits the transportation of Carboxydichlorofluorescein by ABCC5 (IC50 = 218 microM)			[4]
Affected Drug/Substrate	Carboxydichlorofluorescein	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MRP5
DT Modulation4	Trequinsin inhibits the transportation of Cyclic guanosine monophosphate by ABCC5 (Ki = 0.24 microM)			[5]
Affected Drug/Substrate	Cyclic guanosine monophosphate	Modulation Type	Inhibition
Cell System	Chinese hamster lung fibroblasts V79 cells (V79)-MRP5
Zaprinast	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Zaprinast inhibits the transportation of 5-Fluorodeoxyuridine monophosphate by ABCC5 (IC50 = 20 microM)			[1]
Affected Drug/Substrate	5-Fluorodeoxyuridine monophosphate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MRP5
DT Modulation2	Zaprinast inhibits the transportation of 9-(2-Phosphonomethoxyethyl)adenine by ABCC5 (IC50 = 250 microM)			[3]
Affected Drug/Substrate	9-(2-Phosphonomethoxyethyl)adenine	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MRP4
DT Modulation3	Zaprinast inhibits the transportation of Carboxydichlorofluorescein by ABCC5 (IC50 = 32.3 microM)			[4]
Affected Drug/Substrate	Carboxydichlorofluorescein	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MRP5
DT Modulation4	Zaprinast inhibits the transportation of Cyclic guanosine monophosphate by ABCC5			[6]
Affected Drug/Substrate	Cyclic guanosine monophosphate	Modulation Type	Inhibition
MK-571	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	MK-571 inhibits the transportation of 5-Fluorodeoxyuridine monophosphate by ABCC5 (IC50 = 17 microM)			[1]
Affected Drug/Substrate	5-Fluorodeoxyuridine monophosphate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MRP5
DT Modulation2	MK-571 inhibits the transportation of 9-(2-Phosphonomethoxyethyl)adenine by ABCC5 (IC50 = 200 microM)			[3]
Affected Drug/Substrate	9-(2-Phosphonomethoxyethyl)adenine	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MRP4
DT Modulation3	MK-571 inhibits the transportation of Carboxydichlorofluorescein by ABCC5 (IC50 = 15.9 microM)			[4]
Affected Drug/Substrate	Carboxydichlorofluorescein	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MRP5
Investigative Drug
Cyclic AMP	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cyclic adenosine monophosphate inhibits the transportation of Cyclic guanosine monophosphate by ABCC5			[5]
Affected Drug/Substrate	Cyclic guanosine monophosphate	Modulation Type	Inhibition
Cell System	Chinese hamster lung fibroblasts V79 cells (V79)-MRP5
4-(2-Aminoethyl) benzenesulfonyl fluoride	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	4-(2-Aminoethyl) benzenesulfonyl fluoride inhibits the activity of ABCC5			[42]
Natural Product
DT Modulation1	Curcumin analog binds to and results in decreased activity of ABCC5 protein			[61]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Curcumin analog binds to and results in decreased activity of ABCC5 protein which results in decreased export of Hyaluronic Acid			[61]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Curcumin analog inhibits the reaction ABCC5 protein results in increased export of Hyaluronic Acid			[61]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Curcumin binds to and results in decreased activity of ABCC5 protein			[61]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Curcumin binds to and results in decreased activity of ABCC5 protein which results in decreased export of Hyaluronic Acid			[61]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Curcumin inhibits the reaction ABCC5 protein results in increased export of Hyaluronic Acid			[61]
Regulation Mechanism				Transcription Factor Info
Plant polyphenols	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Plant polyphenols inhibits the activity of ABCC5			[8]
Cell System	Human embryonic kidney 293 cells (HEK293)-MRP5
Silymarin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Silymarin inhibits the activity of ABCC5			[8]
Cell System	Human embryonic kidney 293 cells (HEK293)-MRP5
Particulate Matter	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Particulate Matter increases the expression of ABCC5			[34]
Deguelin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Deguelin inhibits the expression of ABCC5			[22]
Tobacco Smoke Pollution	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tobacco Smoke Pollution inhibits the expression of ABCC5			[41]
Quercetin	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCC5 protein results in decreased susceptibility to Quercetin			[8]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Quercetin inhibits the reaction ABCC5 protein results in decreased susceptibility to Thioguanine			[8]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Quercetin inhibits the reaction ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein			[8]
Regulation Mechanism				Transcription Factor Info
Resveratrol	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCC5 protein results in decreased susceptibility to Resveratrol			[8]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Resveratrol inhibits the reaction ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein			[8]
Regulation Mechanism				Transcription Factor Info
Chrysin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Chrysin inhibits the expression of ABCC5			[33]
Regulation Mechanism	via the inhibition of Nuclear factor erythroid 2-related factor 2 (NFE2L2)			Transcription Factor Info
Affected Drug/Substrate	Doxorubicin	Modulation Type	Inhibition
Cell System	Human endocervical adenocarcinoma cells (BEL-7402)
Traditional Medicine
Jinfukang	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Jinfukang increases the expression of ABCC5			[37]
Environmental toxicant
Polychlorinated dibenzodioxin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Polychlorinated dibenzodioxin increases the expression of ABCC5			[28]
Regulation Mechanism	via enhancement of Aryl hydrocarbon receptor (AHR)			Transcription Factor Info
Cell System	Human gastric signet ring cell adenocarcinoma cells (SNU-601)
Acute Toxic Substance
Cycloheximide	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cycloheximide inhibits the expression of ABCC5			[9]
2-butenal	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	2-butenal inhibits the expression of ABCC5			[30]
Formaldehyde	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Formaldehyde increases the expression of ABCC5			[32]
Carcinogen
Benzo(a)pyrene	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Benzo(a)pyrene increases the expression of ABCC5			[31]
Ethyl Methanesulfonate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ethyl Methanesulfonate increases the expression of ABCC5			[32]
Fungicide
Azoxystrobin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Azoxystrobin inhibits the expression of ABCC5			[22]
Pesticide/Insecticide
Dicrotophos	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Dicrotophos increases the expression of ABCC5			[38]
Health and Environmental Toxicant
Perfluorooctane sulfonic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Perfluorooctane sulfonic acid inhibits the expression of ABCC5			[40]

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