Detail Information of Exogenous Modulation

General Information of Drug Transporter (DT)
DT ID	DTD0015 Transporter Info
Gene Name	ABCC4
Transporter Name	Multidrug resistance-associated protein 4
Gene ID	10257
UniProt ID	O15439

Exogenous factors (drugs, dietary constituents, etc.) Modulation of This DT (EGM)
Chemical Compound
DT Modulation1	Probenecid inhibits the reaction ABCC4 protein results in increased transport of Cyclic GMP			[3]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Dipyridamole inhibits the reaction ABCC4 protein results in increased transport of Cyclic GMP			[3]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Dipyridamole results in decreased activity of ABCC4 protein			[96]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Celecoxib results in decreased activity of ABCC4 protein			[75]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Celecoxib results in increased expression of ABCC4 mRNA			[88]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Celecoxib results in increased expression of ABCC4 protein			[88]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Diclofenac affects the expression of ABCC4 mRNA			[24]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	ABCC4 protein results in increased transport of Cefmetazole			[76]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	hesperetin inhibits the reaction ABCC4 protein results in decreased susceptibility to Thioguanine			[15]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Quercetin inhibits the reaction ABCC4 protein results in decreased susceptibility to Thioguanine			[15]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	verlukast inhibits the reaction ABCC4 protein results in decreased susceptibility to Thioguanine			[15]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Silymarin inhibits the reaction ABCC4 protein results in increased export of Cyclic GMP			[15]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Silymarin inhibits the reaction ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate			[15]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Silymarin inhibits the reaction Alprostadil promotes the reaction ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate			[15]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	ABCC4 protein affects the abundance of Zidovudine			[73]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	ABCC4 protein results in increased export of Zidovudine			[73]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	2,4-dinitrophenyl-S-(N-acetylcysteine) inhibits the reaction ABCC4 protein results in increased transport of Methotrexate			[3]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	4-nitrophenylglucuronide inhibits the reaction ABCC4 protein results in increased transport of Methotrexate			[3]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	ABCC4 gene SNP affects the susceptibility to Methotrexate			[104]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	ABCC4 protein results in decreased susceptibility to Methotrexate			[62]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	ABCC4 protein results in increased export of Methotrexate			[103]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	ABCC4 protein results in increased transport of Methotrexate			[3]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	hippuric acid inhibits the reaction ABCC4 protein results in increased export of Methotrexate			[103]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	Indican inhibits the reaction ABCC4 protein results in increased export of Methotrexate			[103]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	indoleacetic acid inhibits the reaction ABCC4 protein results in increased export of Methotrexate			[103]
Regulation Mechanism				Transcription Factor Info
DT Modulation10	Kynurenic Acid inhibits the reaction ABCC4 protein results in increased export of Methotrexate			[103]
Regulation Mechanism				Transcription Factor Info
DT Modulation11	naphthyl glucuronide inhibits the reaction ABCC4 protein results in increased transport of Methotrexate			[3]
Regulation Mechanism				Transcription Factor Info
DT Modulation12	phenylacetic acid inhibits the reaction ABCC4 protein results in increased export of Methotrexate			[103]
Regulation Mechanism				Transcription Factor Info
DT Modulation13	S-(2,4-dinitrophenyl)glutathione inhibits the reaction ABCC4 protein results in increased transport of Methotrexate			[3]
Regulation Mechanism				Transcription Factor Info
DT Modulation14	Uric Acid inhibits the reaction ABCC4 protein affects the transport of Methotrexate			[105]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Tolvaptan metabolite results in decreased activity of ABCC4 protein			[25]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	ABCC4 protein results in decreased susceptibility to Cisplatin			[90]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Cisplatin results in increased expression of ABCC4 protein			[91]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of ABCC4 mRNA			[54]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Valproic Acid inhibits the reaction Colforsin results in decreased expression of ABCC4 mRNA			[93]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Valproic Acid results in decreased activity of ABCC4 protein			[75]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Valproic Acid results in increased expression of ABCC4 mRNA			[120]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Estradiol co-treated with Progesterone results in increased expression of ABCC4 mRNA			[99]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Estradiol co-treated with Tetrachlorodibenzodioxin results in increased expression of ABCC4 mRNA			[100]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Cyclosporine affects the expression of ABCC4 mRNA			[94]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Tretinoin results in increased expression of ABCC4 mRNA			[116]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	ABCC4 protein results in increased transport of Furosemide			[76]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Furosemide results in decreased activity of ABCC4 protein			[75]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased expression of ABCC4 mRNA			[54]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	TAK-875 analog results in decreased activity of ABCC4 protein			[55]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	TAK-875 inhibits the reaction ABCC4 protein results in increased transport of Bile Acids and Salts			[114]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	TAK-875 results in decreased activity of ABCC4 protein			[114]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	ABCC4 protein binds to and results in increased hydrolysis of Adenosine Triphosphate			[67]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate			[15]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Adenosine Triphosphate affects the activity of ABCC4 protein			[58]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Adenosine Triphosphate affects the activity of ABCC4 protein which results in increased transport of Acetaminophen metabolite			[58]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	daidzein promotes the reaction ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate			[15]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Disulfiram inhibits the reaction ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate			[67]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	hesperetin promotes the reaction ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate			[15]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	naringenin promotes the reaction ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate			[15]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	Quercetin affects the reaction ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate			[15]
Regulation Mechanism				Transcription Factor Info
DT Modulation10	Quercetin inhibits the reaction Alprostadil promotes the reaction ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate			[15]
Regulation Mechanism				Transcription Factor Info
DT Modulation11	Resveratrol promotes the reaction ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate			[15]
Regulation Mechanism				Transcription Factor Info
DT Modulation12	Silymarin inhibits the reaction ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate			[15]
Regulation Mechanism				Transcription Factor Info
DT Modulation13	Silymarin inhibits the reaction Alprostadil promotes the reaction ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate			[15]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Benzo(a)pyrene affects the methylation of ABCC4 intron			[74]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Benzo(a)pyrene results in decreased methylation of ABCC4 3' UTR			[80]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Benzo(a)pyrene results in increased methylation of ABCC4 promoter			[80]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Dihydrotestosterone results in increased expression of ABCC4 mRNA			[62]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Dihydrotestosterone results in increased expression of ABCC4 protein			[62]
Regulation Mechanism				Transcription Factor Info
2,6-dibromobenzoquinone	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCC4 protein inhibits the reaction 2,6-dibromobenzoquinone results in increased abundance of Reactive Oxygen Species			[63]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	ABCC4 protein results in decreased susceptibility to 2,6-dibromobenzoquinone			[63]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	ABCC4 protein results in increased export of 2,6-dibromobenzoquinone binds to Glutathione			[63]
Regulation Mechanism				Transcription Factor Info
2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Mefloquine inhibits the reaction ABCC4 protein affects the export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein			[64]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	verlukast inhibits the reaction ABCC4 protein affects the export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein			[64]
Regulation Mechanism				Transcription Factor Info
2-palmitoylglycerol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	2-palmitoylglycerol results in increased expression of ABCC4 mRNA			[65]
Regulation Mechanism				Transcription Factor Info
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased expression of ABCC4 mRNA			[54]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased expression of ABCC4 mRNA			[54]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased expression of ABCC4 mRNA			[54]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of ABCC4 mRNA			[54]
Regulation Mechanism				Transcription Factor Info
4-nitrophenylglucuronide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	4-nitrophenylglucuronide inhibits the reaction ABCC4 protein results in increased transport of Methotrexate			[3]
Regulation Mechanism				Transcription Factor Info
4-phenylbutylamine	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	4-phenylbutylamine results in increased expression of ABCC4 mRNA			[43]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	4-phenylbutylamine results in increased expression of ABCC4 protein			[43]
Regulation Mechanism				Transcription Factor Info
7-hydroxymethotrexate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCC4 gene mutant form affects the susceptibility to 7-hydroxymethotrexate			[66]
Regulation Mechanism				Transcription Factor Info
7-hydroxytheonellasterol	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	7-hydroxytheonellasterol inhibits the reaction Chenodeoxycholic Acid promotes the reaction NR1H4 protein binds to ABCC4 promoter			[22]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	7-hydroxytheonellasterol inhibits the reaction Chenodeoxycholic Acid promotes the reaction NR1H4 protein binds to ABCC4 promoter which results in decreased expression of ABCC4 mRNA			[22]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	7-hydroxytheonellasterol inhibits the reaction Chenodeoxycholic Acid results in decreased expression of ABCC4 mRNA			[22]
Regulation Mechanism				Transcription Factor Info
8-azidoadenosine 5'-triphosphate	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	8-azidoadenosine 5'-triphosphate binds to ABCC4 protein			[67]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	ABCC4 protein binds to 8-azidoadenosine 5'-triphosphate			[15]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Disulfiram inhibits the reaction 8-azidoadenosine 5'-triphosphate binds to ABCC4 protein			[67]
Regulation Mechanism				Transcription Factor Info
abrine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	abrine results in decreased expression of ABCC4 mRNA			[68]
Regulation Mechanism				Transcription Factor Info
Acrolein	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone affects the expression of ABCC4 mRNA			[72]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Air Pollutants results in increased abundance of Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone which affects the expression of ABCC4 mRNA			[72]
Regulation Mechanism				Transcription Factor Info
adefovir	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCC4 protein affects the abundance of adefovir			[73]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	ABCC4 protein results in increased export of adefovir			[73]
Regulation Mechanism				Transcription Factor Info
allyl sulfide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	allyl sulfide results in decreased expression of ABCC4 mRNA			[49]
Regulation Mechanism				Transcription Factor Info
alpha-pinene	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone affects the expression of ABCC4 mRNA			[72]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Air Pollutants results in increased abundance of Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone which affects the expression of ABCC4 mRNA			[72]
Regulation Mechanism				Transcription Factor Info
Alprostadil	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Quercetin inhibits the reaction Alprostadil promotes the reaction ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate			[15]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Silymarin inhibits the reaction Alprostadil promotes the reaction ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate			[15]
Regulation Mechanism				Transcription Factor Info
Aminopyrine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Aminopyrine results in decreased activity of ABCC4 protein			[75]
Regulation Mechanism				Transcription Factor Info
Ampicillin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCC4 protein results in increased transport of Ampicillin			[76]
Regulation Mechanism				Transcription Factor Info
aristolochic acid I	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	aristolochic acid I results in decreased expression of ABCC4 mRNA			[77]
Regulation Mechanism				Transcription Factor Info
Baclofen	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCC4 protein results in increased transport of Baclofen			[76]
Regulation Mechanism				Transcription Factor Info
benzo(a)pyrene 7,8-dihydrodiol	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCC4 protein results in increased export of benzo(a)pyrene 7,8-dihydrodiol			[44]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	ABCC4 protein results in increased export of benzo(a)pyrene 7,8-dihydrodiol which results in decreased chemical synthesis of benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide-DNA			[44]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	benzo(a)pyrene 7,8-dihydrodiol results in increased expression of ABCC4 mRNA			[44]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	benzo(a)pyrene 7,8-dihydrodiol results in increased expression of ABCC4 protein			[44]
Regulation Mechanism				Transcription Factor Info
benzo(e)pyrene	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	benzo(e)pyrene results in increased methylation of ABCC4 intron			[74]
Regulation Mechanism				Transcription Factor Info
Bezafibrate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCC4 protein results in increased transport of Bezafibrate			[76]
Regulation Mechanism				Transcription Factor Info
bisphenol A	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	bisphenol A co-treated with Fulvestrant results in decreased methylation of ABCC4 gene			[81]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	bisphenol A results in decreased methylation of ABCC4 gene			[81]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	bisphenol A results in increased expression of ABCC4 mRNA			[82]
Regulation Mechanism				Transcription Factor Info
bisphenol S	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	bisphenol S results in decreased methylation of ABCC4 gene			[81]
Regulation Mechanism				Transcription Factor Info
Bumetanide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCC4 protein results in increased transport of Bumetanide			[76]
Regulation Mechanism				Transcription Factor Info
butylbenzyl phthalate	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	butylbenzyl phthalate results in increased expression of ABCC4 mRNA			[83]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	dimethyl phthalate co-treated with diethyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with Diethylhexyl Phthalate results in increased expression of ABCC4 mRNA			[83]
Regulation Mechanism				Transcription Factor Info
Cacodylic Acid	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCC4 gene SNP affects the export of Cacodylic Acid			[84]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	ABCC4 protein results in increased export of Cacodylic Acid			[85]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	ABCC4 protein results in increased transport of Cacodylic Acid			[78]
Regulation Mechanism				Transcription Factor Info
calcein AM	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Glutathione promotes the reaction ABCC4 protein affects the transport of calcein AM			[87]
Regulation Mechanism				Transcription Factor Info
Ceftazidime	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCC4 protein results in increased transport of Ceftazidime			[76]
Regulation Mechanism				Transcription Factor Info
cephalosporin C	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCC4 protein results in increased transport of cephalosporin C			[76]
Regulation Mechanism				Transcription Factor Info
Chenodeoxycholic Acid	10 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	7-hydroxytheonellasterol inhibits the reaction Chenodeoxycholic Acid promotes the reaction NR1H4 protein binds to ABCC4 promoter			[22]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	7-hydroxytheonellasterol inhibits the reaction Chenodeoxycholic Acid promotes the reaction NR1H4 protein binds to ABCC4 promoter which results in decreased expression of ABCC4 mRNA			[22]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	7-hydroxytheonellasterol inhibits the reaction Chenodeoxycholic Acid results in decreased expression of ABCC4 mRNA			[22]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Chenodeoxycholic Acid promotes the reaction NR1H4 protein binds to ABCC4 promoter			[22]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Chenodeoxycholic Acid promotes the reaction NR1H4 protein binds to ABCC4 promoter which results in decreased expression of ABCC4 mRNA			[22]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Chenodeoxycholic Acid results in decreased expression of ABCC4 mRNA			[22]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Acetaminophen results in increased expression of ABCC4 mRNA			[71]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Tartrazine results in increased expression of ABCC4 mRNA			[71]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Triclosan results in increased expression of ABCC4 mRNA			[71]
Regulation Mechanism				Transcription Factor Info
DT Modulation10	nefazodone co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid results in increased expression of ABCC4 mRNA			[32]
Regulation Mechanism				Transcription Factor Info
Cholecalciferol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cholecalciferol results in decreased expression of ABCC4 mRNA			[19]
Regulation Mechanism				Transcription Factor Info
Ciprofloxacin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ciprofloxacin results in increased expression of ABCC4 protein which results in decreased uptake of Ciprofloxacin			[89]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Gemfibrozil inhibits the reaction Ciprofloxacin results in increased expression of ABCC4 protein which results in decreased uptake of Ciprofloxacin			[89]
Regulation Mechanism				Transcription Factor Info
Clozapine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Clozapine results in decreased activity of ABCC4 protein			[75]
Regulation Mechanism				Transcription Factor Info
cobaltous chloride	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	cobaltous chloride results in decreased expression of ABCC4 mRNA			[92]
Regulation Mechanism				Transcription Factor Info
Colforsin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Colforsin results in decreased expression of ABCC4 mRNA			[93]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Valproic Acid inhibits the reaction Colforsin results in decreased expression of ABCC4 mRNA			[93]
Regulation Mechanism				Transcription Factor Info
coumarin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	coumarin results in increased phosphorylation of ABCC4 protein			[86]
Regulation Mechanism				Transcription Factor Info
Cyclic AMP	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCC4 protein results in increased transport of Cyclic AMP			[3]
Regulation Mechanism				Transcription Factor Info
Cyclic GMP	10 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCC4 protein results in increased export of Cyclic GMP			[15]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	ABCC4 protein results in increased transport of Cyclic GMP			[3]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	daidzein inhibits the reaction ABCC4 protein results in increased export of Cyclic GMP			[15]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Dipyridamole inhibits the reaction ABCC4 protein results in increased transport of Cyclic GMP			[3]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	hesperetin inhibits the reaction ABCC4 protein results in increased export of Cyclic GMP			[15]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	naringenin inhibits the reaction ABCC4 protein results in increased export of Cyclic GMP			[15]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	Probenecid inhibits the reaction ABCC4 protein results in increased transport of Cyclic GMP			[3]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	Quercetin inhibits the reaction ABCC4 protein results in increased export of Cyclic GMP			[15]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	Resveratrol inhibits the reaction ABCC4 protein results in increased export of Cyclic GMP			[15]
Regulation Mechanism				Transcription Factor Info
DT Modulation10	Silymarin inhibits the reaction ABCC4 protein results in increased export of Cyclic GMP			[15]
Regulation Mechanism				Transcription Factor Info
daidzein	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	daidzein inhibits the reaction ABCC4 protein results in increased export of Cyclic GMP			[15]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	daidzein promotes the reaction ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate			[15]
Regulation Mechanism				Transcription Factor Info
deguelin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	deguelin results in increased expression of ABCC4 mRNA			[34]
Regulation Mechanism				Transcription Factor Info
Deoxycholic Acid	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Acetaminophen results in increased expression of ABCC4 mRNA			[71]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Tartrazine results in increased expression of ABCC4 mRNA			[71]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Triclosan results in increased expression of ABCC4 mRNA			[71]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	nefazodone co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid results in increased expression of ABCC4 mRNA			[32]
Regulation Mechanism				Transcription Factor Info
diallyl disulfide	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	diallyl disulfide results in decreased expression of ABCC4 mRNA			[49]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	diallyl disulfide results in increased expression of ABCC4 mRNA			[49]
Regulation Mechanism				Transcription Factor Info
diallyl trisulfide	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	diallyl trisulfide results in decreased expression of ABCC4 mRNA			[49]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	diallyl trisulfide results in increased expression of ABCC4 mRNA			[49]
Regulation Mechanism				Transcription Factor Info
Diazinon	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Diazinon results in increased methylation of ABCC4 gene			[95]
Regulation Mechanism				Transcription Factor Info
Dibutyl Phthalate	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Dibutyl Phthalate results in increased expression of ABCC4 mRNA			[83]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	dimethyl phthalate co-treated with diethyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with Diethylhexyl Phthalate results in increased expression of ABCC4 mRNA			[83]
Regulation Mechanism				Transcription Factor Info
Diethylhexyl Phthalate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	dimethyl phthalate co-treated with diethyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with Diethylhexyl Phthalate results in increased expression of ABCC4 mRNA			[83]
Regulation Mechanism				Transcription Factor Info
diethyl phthalate	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	diethyl phthalate results in increased expression of ABCC4 mRNA			[83]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	dimethyl phthalate co-treated with diethyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with Diethylhexyl Phthalate results in increased expression of ABCC4 mRNA			[83]
Regulation Mechanism				Transcription Factor Info
dimethyl phthalate	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	dimethyl phthalate co-treated with diethyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with Diethylhexyl Phthalate results in increased expression of ABCC4 mRNA			[83]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	dimethyl phthalate results in increased expression of ABCC4 mRNA			[83]
Regulation Mechanism				Transcription Factor Info
Dinoprostone	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCC4 gene SNP affects the export of Dinoprostone			[84]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	ABCC4 protein results in increased export of Dinoprostone			[44]
Regulation Mechanism				Transcription Factor Info
Disulfiram	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Disulfiram inhibits the reaction 8-azidoadenosine 5'-triphosphate binds to ABCC4 protein			[67]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Disulfiram inhibits the reaction ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate			[67]
Regulation Mechanism				Transcription Factor Info
Docetaxel	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Docetaxel results in decreased susceptibility to Docetaxel which results in decreased expression of ABCC4 mRNA			[97]
Regulation Mechanism				Transcription Factor Info
Donepezil	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Donepezil results in decreased activity of ABCC4 protein			[75]
Regulation Mechanism				Transcription Factor Info
dorsomorphin	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased expression of ABCC4 mRNA			[54]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased expression of ABCC4 mRNA			[54]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased expression of ABCC4 mRNA			[54]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of ABCC4 mRNA			[54]
Regulation Mechanism				Transcription Factor Info
Enalapril	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCC4 protein results in increased transport of Enalapril			[76]
Regulation Mechanism				Transcription Factor Info
entinostat	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	entinostat results in increased expression of ABCC4 mRNA			[54]
Regulation Mechanism				Transcription Factor Info
enzalutamide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	enzalutamide results in decreased expression of ABCC4 mRNA			[28]
Regulation Mechanism				Transcription Factor Info
EPZ004777	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	EPZ004777 inhibits the reaction AR protein binds to ABCC4 promoter			[98]
Regulation Mechanism				Transcription Factor Info
Erythromycin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Erythromycin results in decreased activity of ABCC4 protein			[75]
Regulation Mechanism				Transcription Factor Info
Fluoxetine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Fluoxetine results in decreased activity of ABCC4 protein			[75]
Regulation Mechanism				Transcription Factor Info
FR900359	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	FR900359 affects the phosphorylation of ABCC4 protein			[101]
Regulation Mechanism				Transcription Factor Info
Fulvestrant	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	bisphenol A co-treated with Fulvestrant results in decreased methylation of ABCC4 gene			[81]
Regulation Mechanism				Transcription Factor Info
Gemfibrozil	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Gemfibrozil inhibits the reaction Ciprofloxacin results in increased expression of ABCC4 protein which results in decreased uptake of Ciprofloxacin			[89]
Regulation Mechanism				Transcription Factor Info
Glutathione	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCC4 protein affects the transport of Glutathione analog			[102]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	ABCC4 protein results in increased export of 2,6-dibromobenzoquinone binds to Glutathione			[63]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	ABCC4 protein results in increased export of 2,6-dichloro-(1,4)benzoquinone binds to Glutathione			[63]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Glutathione promotes the reaction ABCC4 protein affects the transport of calcein AM			[87]
Regulation Mechanism				Transcription Factor Info
Glycochenodeoxycholic Acid	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Acetaminophen results in increased expression of ABCC4 mRNA			[71]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Tartrazine results in increased expression of ABCC4 mRNA			[71]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Triclosan results in increased expression of ABCC4 mRNA			[71]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	nefazodone co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid results in increased expression of ABCC4 mRNA			[32]
Regulation Mechanism				Transcription Factor Info
Glycocholic Acid	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Acetaminophen results in increased expression of ABCC4 mRNA			[71]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Tartrazine results in increased expression of ABCC4 mRNA			[71]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Triclosan results in increased expression of ABCC4 mRNA			[71]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	nefazodone co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid results in increased expression of ABCC4 mRNA			[32]
Regulation Mechanism				Transcription Factor Info
Glycodeoxycholic Acid	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Acetaminophen results in increased expression of ABCC4 mRNA			[71]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Tartrazine results in increased expression of ABCC4 mRNA			[71]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Triclosan results in increased expression of ABCC4 mRNA			[71]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	nefazodone co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid results in increased expression of ABCC4 mRNA			[32]
Regulation Mechanism				Transcription Factor Info
hesperetin	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	hesperetin inhibits the reaction ABCC4 protein results in decreased susceptibility to Thioguanine			[15]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	hesperetin inhibits the reaction ABCC4 protein results in increased export of Cyclic GMP			[15]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	hesperetin promotes the reaction ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate			[15]
Regulation Mechanism				Transcription Factor Info
hippuric acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	hippuric acid inhibits the reaction ABCC4 protein results in increased export of Methotrexate			[103]
Regulation Mechanism				Transcription Factor Info
Hydrochlorothiazide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCC4 protein results in increased transport of Hydrochlorothiazide			[76]
Regulation Mechanism				Transcription Factor Info
Indican	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Indican inhibits the reaction ABCC4 protein results in increased export of Methotrexate			[103]
Regulation Mechanism				Transcription Factor Info
indoleacetic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	indoleacetic acid inhibits the reaction ABCC4 protein results in increased export of Methotrexate			[103]
Regulation Mechanism				Transcription Factor Info
Irinotecan	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCC4 protein affects the export of Irinotecan			[96]
Regulation Mechanism				Transcription Factor Info
Kanamycin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Kanamycin results in decreased activity of ABCC4 protein			[75]
Regulation Mechanism				Transcription Factor Info
Kynurenic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Kynurenic Acid inhibits the reaction ABCC4 protein results in increased export of Methotrexate			[103]
Regulation Mechanism				Transcription Factor Info
Levofloxacin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Levofloxacin results in decreased activity of ABCC4 protein			[75]
Regulation Mechanism				Transcription Factor Info
Mefloquine	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Mefloquine inhibits the reaction ABCC4 protein affects the export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein			[64]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Mefloquine inhibits the reaction Prostaglandins E results in increased activity of ABCC4 protein			[64]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Mefloquine inhibits the reaction Quercetin results in increased activity of ABCC4 protein			[64]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Mefloquine results in decreased activity of ABCC4 protein			[64]
Regulation Mechanism				Transcription Factor Info
Meloxicam	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCC4 protein binds to Meloxicam			[76]
Regulation Mechanism				Transcription Factor Info
mercuric bromide	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	mercuric bromide results in decreased expression of ABCC4 mRNA			[53]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased expression of ABCC4 mRNA			[54]
Regulation Mechanism				Transcription Factor Info
methacrylaldehyde	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone affects the expression of ABCC4 mRNA			[72]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Air Pollutants results in increased abundance of Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone which affects the expression of ABCC4 mRNA			[72]
Regulation Mechanism				Transcription Factor Info
Methapyrilene	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Methapyrilene results in increased methylation of ABCC4 intron			[74]
Regulation Mechanism				Transcription Factor Info
methylarsenic diglutathione	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCC4 protein results in increased export of methylarsenic diglutathione			[85]
Regulation Mechanism				Transcription Factor Info
methylmercuric chloride	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	methylmercuric chloride results in decreased expression of ABCC4 mRNA			[27]
Regulation Mechanism				Transcription Factor Info
Methyl Methanesulfonate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Methyl Methanesulfonate results in decreased expression of ABCC4 mRNA			[50]
Regulation Mechanism				Transcription Factor Info
methylselenic acid	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	AR protein inhibits the reaction methylselenic acid results in decreased expression of ABCC4 mRNA			[106]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	methylselenic acid affects the expression of ABCC4 mRNA			[107]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	methylselenic acid results in decreased expression of ABCC4 mRNA			[106]
Regulation Mechanism				Transcription Factor Info
monomethylarsonous acid	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCC4 gene SNP affects the export of monomethylarsonous acid metabolite			[84]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	ABCC4 protein results in increased export of monomethylarsonous acid metabolite			[84]
Regulation Mechanism				Transcription Factor Info
N-acetyl-L-arginine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCC4 protein affects the transport of N-acetyl-L-arginine			[108]
Regulation Mechanism				Transcription Factor Info
naphthyl glucuronide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	naphthyl glucuronide inhibits the reaction ABCC4 protein results in increased transport of Methotrexate			[3]
Regulation Mechanism				Transcription Factor Info
naringenin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	naringenin inhibits the reaction ABCC4 protein results in increased export of Cyclic GMP			[15]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	naringenin promotes the reaction ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate			[15]
Regulation Mechanism				Transcription Factor Info
Nateglinide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCC4 protein binds to Nateglinide			[76]
Regulation Mechanism				Transcription Factor Info
nefazodone	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	nefazodone co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid results in increased expression of ABCC4 mRNA			[32]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	nefazodone results in increased expression of ABCC4 mRNA			[32]
Regulation Mechanism				Transcription Factor Info
oltipraz	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	oltipraz promotes the reaction ABCC4 protein results in increased transport of Arsenic			[78]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	oltipraz results in increased expression of ABCC4 mRNA			[43]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	oltipraz results in increased expression of ABCC4 protein			[43]
Regulation Mechanism				Transcription Factor Info
Oxygen	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Oxygen deficiency results in decreased expression of ABCC4 mRNA			[109]
Regulation Mechanism				Transcription Factor Info
Ozone	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone affects the expression of ABCC4 mRNA			[72]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Air Pollutants results in increased abundance of Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone which affects the expression of ABCC4 mRNA			[72]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Volatile Organic Compounds co-treated with Ozone affects the expression of ABCC4 mRNA			[72]
Regulation Mechanism				Transcription Factor Info
p-Chloromercuribenzoic Acid	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased expression of ABCC4 mRNA			[54]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	p-Chloromercuribenzoic Acid results in decreased expression of ABCC4 mRNA			[53]
Regulation Mechanism				Transcription Factor Info
Penicillin G	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCC4 protein results in increased transport of Penicillin G			[76]
Regulation Mechanism				Transcription Factor Info
perfluorooctane sulfonic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	perfluorooctane sulfonic acid results in decreased activity of ABCC4 protein			[51]
Regulation Mechanism				Transcription Factor Info
perfluorooctanoic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	perfluorooctanoic acid results in decreased activity of ABCC4 protein			[51]
Regulation Mechanism				Transcription Factor Info
PF-06840003	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	PF-06840003 inhibits the reaction APAF1 protein mutant form results in increased expression of ABCC4 mRNA			[111]
Regulation Mechanism				Transcription Factor Info
phenylacetic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	phenylacetic acid inhibits the reaction ABCC4 protein results in increased export of Methotrexate			[103]
Regulation Mechanism				Transcription Factor Info
picoxystrobin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	picoxystrobin results in increased expression of ABCC4 mRNA			[34]
Regulation Mechanism				Transcription Factor Info
Pipemidic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCC4 protein results in increased transport of Pipemidic Acid			[76]
Regulation Mechanism				Transcription Factor Info
Piperacillin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCC4 protein results in increased transport of Piperacillin			[76]
Regulation Mechanism				Transcription Factor Info
pirinixic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	pirinixic acid binds to and results in increased activity of PPARA protein which results in decreased expression of ABCC4 mRNA			[112]
Regulation Mechanism				Transcription Factor Info
Pravastatin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCC4 protein results in increased transport of Pravastatin			[76]
Regulation Mechanism				Transcription Factor Info
Progesterone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Estradiol co-treated with Progesterone results in increased expression of ABCC4 mRNA			[99]
Regulation Mechanism				Transcription Factor Info
pyrachlostrobin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	pyrachlostrobin results in increased expression of ABCC4 mRNA			[34]
Regulation Mechanism				Transcription Factor Info
quercitrin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	quercitrin results in decreased expression of ABCC4 mRNA			[52]
Regulation Mechanism				Transcription Factor Info
rebamipide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCC4 protein results in increased transport of rebamipide			[76]
Regulation Mechanism				Transcription Factor Info
Ritonavir	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ritonavir results in decreased activity of ABCC4 protein			[75]
Regulation Mechanism				Transcription Factor Info
S-(2,4-dinitrophenyl)glutathione	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	S-(2,4-dinitrophenyl)glutathione inhibits the reaction ABCC4 protein results in increased transport of Methotrexate			[3]
Regulation Mechanism				Transcription Factor Info
sodium arsenite	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	sodium arsenite results in increased expression of ABCC4 mRNA			[59]
Regulation Mechanism				Transcription Factor Info
sodium selenide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	sodium selenide inhibits the reaction arsenite results in increased expression of ABCC4 protein			[113]
Regulation Mechanism				Transcription Factor Info
Sodium Selenite	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sodium Selenite inhibits the reaction arsenite results in increased expression of ABCC4 protein			[113]
Regulation Mechanism				Transcription Factor Info
Sulbactam	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCC4 protein results in increased transport of Sulbactam			[76]
Regulation Mechanism				Transcription Factor Info
tanshinone	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	tanshinone co-treated with Acetaminophen results in increased expression of ABCC4 mRNA			[70]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	tanshinone co-treated with Acetaminophen results in increased expression of ABCC4 protein			[70]
Regulation Mechanism				Transcription Factor Info
Tartrazine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Tartrazine results in increased expression of ABCC4 mRNA			[71]
Regulation Mechanism				Transcription Factor Info
tetrabromobisphenol A	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	tetrabromobisphenol A results in decreased activity of ABCC4 protein			[51]
Regulation Mechanism				Transcription Factor Info
Tetrachlorodibenzodioxin	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Estradiol co-treated with Tetrachlorodibenzodioxin results in increased expression of ABCC4 mRNA			[100]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Tetrachlorodibenzodioxin affects the expression of ABCC4 mRNA			[115]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Tetrachlorodibenzodioxin results in increased expression of ABCC4 mRNA			[100]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Tetrachlorodibenzodioxin results in increased expression of ABCC4 protein			[43]
Regulation Mechanism				Transcription Factor Info
Tetracycline	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCC4 protein results in increased transport of Tetracycline			[76]
Regulation Mechanism				Transcription Factor Info
Theophylline	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Theophylline results in decreased activity of ABCC4 protein			[75]
Regulation Mechanism				Transcription Factor Info
Triclosan	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Triclosan results in increased expression of ABCC4 mRNA			[71]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Triclosan results in increased expression of ABCC4 mRNA			[117]
Regulation Mechanism				Transcription Factor Info
triphenyl phosphate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	triphenyl phosphate affects the expression of ABCC4 mRNA			[118]
Regulation Mechanism				Transcription Factor Info
triptolide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	triptolide results in decreased expression of ABCC4 protein			[119]
Regulation Mechanism				Transcription Factor Info
Uric Acid	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCC4 protein affects the export of Uric Acid			[105]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Uric Acid inhibits the reaction ABCC4 protein affects the transport of Methotrexate			[105]
Regulation Mechanism				Transcription Factor Info
verlukast	5 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	verlukast inhibits the reaction ABCC4 protein affects the export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein			[64]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	verlukast inhibits the reaction ABCC4 protein results in decreased susceptibility to Thioguanine			[15]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	verlukast inhibits the reaction Prostaglandins E results in increased activity of ABCC4 protein			[64]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	verlukast inhibits the reaction Quercetin results in increased activity of ABCC4 protein			[64]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	verlukast results in decreased activity of ABCC4 protein			[64]
Regulation Mechanism				Transcription Factor Info
Vincristine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Vincristine results in decreased susceptibility to Vincristine which results in decreased expression of ABCC4 mRNA			[97]
Regulation Mechanism				Transcription Factor Info
zafirlukast	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	zafirlukast results in decreased activity of ABCC4 protein			[75]
Regulation Mechanism				Transcription Factor Info
zomepirac	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	zomepirac results in decreased activity of ABCC4 protein			[75]
Regulation Mechanism				Transcription Factor Info
Nanoparticle
perfluoro-n-nonanoic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	perfluoro-n-nonanoic acid results in increased expression of ABCC4 mRNA			[110]
Regulation Mechanism				Transcription Factor Info
Approved Drug
Probenecid	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Probenecid inhibits the transportation of 9-(2-Phosphonomethoxyethyl)adenine by ABCC4 (IC50 = 2300 microM)			[1]
Affected Drug/Substrate	9-(2-Phosphonomethoxyethyl)adenine	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MRP4
DT Modulation2	Probenecid inhibits the transportation of Cholyltaurine by ABCC4 (IC50 = 100 microM)			[2]
Affected Drug/Substrate	Cholyltaurine	Modulation Type	Inhibition
Cell System	Chinese hamster lung fibroblasts V79 cells (V79)-MRP4
DT Modulation3	Probenecid inhibits the transportation of Cyclic guanosine monophosphate by ABCC4 (IC50 < 100 microM)			[3]
Affected Drug/Substrate	Cyclic guanosine monophosphate	Modulation Type	Inhibition
Cell System	Spodoptera frugiperda (Sf9) cells-MRP4
Dipyridamole	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Dipyridamole inhibits the transportation of 9-(2-Phosphonomethoxyethyl)adenine by ABCC4 (IC50 = 2 microM)			[1]
Affected Drug/Substrate	9-(2-Phosphonomethoxyethyl)adenine	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MRP4
DT Modulation2	Dipyridamole inhibits the transportation of Cholyltaurine by ABCC4 (IC50 < 20 microM)			[2]
Affected Drug/Substrate	Cholyltaurine	Modulation Type	Inhibition
Cell System	Chinese hamster lung fibroblasts V79 cells (V79)-MRP4
Celecoxib	5 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Celecoxib inhibits the transportation of Methotrexate by ABCC4 (IC50 = 35 microM)			[4]
Affected Drug/Substrate	Methotrexate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MRP4
DT Modulation2	Celecoxib inhibits the activity of ABCC4			[8]
Diclofenac	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Diclofenac inhibits the transportation of Methotrexate by ABCC4 (IC50 = 0.006 microM)			[4]
Affected Drug/Substrate	Methotrexate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MRP4
DT Modulation2	Diclofenac inhibits the activity of ABCC4			[4], [8]
Indomethacin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Indomethacin inhibits the transportation of Methotrexate by ABCC4 (IC50 = 6.1 microM)			[4]
Affected Drug/Substrate	Methotrexate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MRP4
DT Modulation2	Indomethacin inhibits the activity of ABCC4			[10], [11]
Ketoprofen	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ketoprofen inhibits the transportation of Methotrexate by ABCC4 (IC50 = 11.9 microM)			[4]
Affected Drug/Substrate	Methotrexate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MRP4
DT Modulation2	Ketoprofen inhibits the activity of ABCC4			[9]
Sulindac	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sulindac inhibits the transportation of Methotrexate by ABCC4 (IC50 = 2.11 microM)			[4]
Affected Drug/Substrate	Methotrexate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MRP4
DT Modulation2	Sulindac inhibits the activity of ABCC4			[12], [13]
Telmisartan	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Telmisartan inhibits the transportation of Uric acid by ABCC4 (IC50 = 11 microM)			[5]
Affected Drug/Substrate	Uric acid	Modulation Type	Inhibition
Cell System	Spodoptera frugiperda (Sf9) cells-MRP4
DT Modulation2	Telmisartan inhibits the activity of ABCC4			[5]
Cefmetazole	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cefmetazole inhibits the transportation of Estradiol-17beta-glucuronide by ABCC4			[6]
Affected Drug/Substrate	Estradiol-17beta-glucuronide	Modulation Type	Inhibition
Cell System	Spodoptera frugiperda 21-MRP4
DT Modulation2	Cefmetazole inhibits the activity of ABCC4			[9]
Folic Acid	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Folic acid inhibits the transportation of Methotrexate by ABCC4			[7]
Affected Drug/Substrate	Methotrexate	Modulation Type	Inhibition
Cell System	Spodoptera frugiperda (Sf9) cells-MRP4
DT Modulation2	Folic acid inhibits the transportation of Sodium taurocholate by ABCC4			[2]
Affected Drug/Substrate	Sodium taurocholate	Modulation Type	Inhibition
Cell System	Chinese hamster lung fibroblasts V79 cells (V79)-MRP4
Benzbromarone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Benzbromarone inhibits the transportation of 9-(2-Phosphonomethoxyethyl)adenine by ABCC4 (IC50 = 150 microM)			[1]
Affected Drug/Substrate	9-(2-Phosphonomethoxyethyl)adenine	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MRP4
Sildenafil	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sildenafil inhibits the transportation of 9-(2-Phosphonomethoxyethyl)adenine by ABCC4 (IC50 = 20 microM)			[1]
Affected Drug/Substrate	9-(2-Phosphonomethoxyethyl)adenine	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MRP4
Sulfinpyrazone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sulfinpyrazone inhibits the transportation of 9-(2-Phosphonomethoxyethyl)adenine by ABCC4 (IC50 = 420 microM)			[1]
Affected Drug/Substrate	9-(2-Phosphonomethoxyethyl)adenine	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MRP4
Candesartan	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Candesartan inhibits the transportation of Uric acid by ABCC4 (IC50 = 16 microM)			[5]
Affected Drug/Substrate	Uric acid	Modulation Type	Inhibition
Cell System	Spodoptera frugiperda (Sf9) cells-MRP4
Losartan	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Losartan inhibits the transportation of Uric acid by ABCC4 (IC50 = 1.5 microM)			[5]
Affected Drug/Substrate	Uric acid	Modulation Type	Inhibition
Cell System	Spodoptera frugiperda (Sf9) cells-MRP4
Thioguanine	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Thioguanine inhibits the transportation of Bimane-glutathione by ABCC4			[14]
Affected Drug/Substrate	Bimane-glutathione	Modulation Type	Inhibition
Cell System	Human hepatocellular carcinoma cell line (HepG2)-MRP4
Quercetin	10 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Quercetin inhibits the transportation of Cyclic guanosine monophosphate by ABCC4			[15]
Affected Drug/Substrate	Cyclic guanosine monophosphate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MRP4
Cefaclor	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cefaclor inhibits the transportation of Estradiol-17beta-glucuronide by ABCC4			[6]
Affected Drug/Substrate	Estradiol-17beta-glucuronide	Modulation Type	Inhibition
Cell System	Spodoptera frugiperda 21-MRP4
Cefadroxil	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cefadroxil inhibits the transportation of Estradiol-17beta-glucuronide by ABCC4			[6]
Affected Drug/Substrate	Estradiol-17beta-glucuronide	Modulation Type	Inhibition
Cell System	Spodoptera frugiperda 21-MRP4
Cefamandole	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cefamandole inhibits the transportation of Estradiol-17beta-glucuronide by ABCC4			[6]
Affected Drug/Substrate	Estradiol-17beta-glucuronide	Modulation Type	Inhibition
Cell System	Spodoptera frugiperda 21-MRP4
Cefoperazone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cefoperazone inhibits the transportation of Estradiol-17beta-glucuronide by ABCC4			[6]
Affected Drug/Substrate	Estradiol-17beta-glucuronide	Modulation Type	Inhibition
Cell System	Spodoptera frugiperda 21-MRP4
Cefoxitin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cefoxitin inhibits the transportation of Estradiol-17beta-glucuronide by ABCC4			[6]
Affected Drug/Substrate	Estradiol-17beta-glucuronide	Modulation Type	Inhibition
Cell System	Spodoptera frugiperda 21-MRP4
Ceftriaxone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ceftriaxone inhibits the transportation of Estradiol-17beta-glucuronide by ABCC4			[6]
Affected Drug/Substrate	Estradiol-17beta-glucuronide	Modulation Type	Inhibition
Cell System	Spodoptera frugiperda 21-MRP4
Cefuroxime	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cefuroxime inhibits the transportation of Estradiol-17beta-glucuronide by ABCC4			[6]
Affected Drug/Substrate	Estradiol-17beta-glucuronide	Modulation Type	Inhibition
Cell System	Spodoptera frugiperda 21-MRP4
Cephalexin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cephalexin inhibits the transportation of Estradiol-17beta-glucuronide by ABCC4			[6]
Affected Drug/Substrate	Estradiol-17beta-glucuronide	Modulation Type	Inhibition
Cell System	Spodoptera frugiperda 21-MRP4
Cephradine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cephradine inhibits the transportation of Estradiol-17beta-glucuronide by ABCC4			[6]
Affected Drug/Substrate	Estradiol-17beta-glucuronide	Modulation Type	Inhibition
Cell System	Spodoptera frugiperda 21-MRP4
Arsenic	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Arsenic increases the expression of ABCC4			[17]
Regulation Mechanism	via enhancement of Nuclear respiratory factor 1 (NRF1)			Transcription Factor Info
Cell System	mouse bone marrow-derived mesenchymal stem cells
Zidovudine	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Zidovudine increases the expression of ABCC4			[18]
Arsenic Trioxide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Arsenic Trioxide inhibits the expression of ABCC4			[19]
Vitamin D	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Vitamin D inhibits the expression of ABCC4			[19]
Bortezomib	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Bortezomib inhibits the expression of ABCC4			[20]
Aspirin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Aspirin increases the expression of ABCC4			[21]
Chenodeoxycholic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Chenodeoxycholic acid inhibits the expression of ABCC4			[22]
Methotrexate	15 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Methotrexate inhibits the expression of ABCC4			[23]
Carbamazepine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Carbamazepine affects the expression of ABCC4			[24]
Tolvaptan	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tolvaptan inhibits the activity of ABCC4			[25]
Cisplatin	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cisplatin inhibits the expression of ABCC4			[26]
Valproic Acid	5 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Valproic Acid inhibits the expression of ABCC4			[27]
Mdv-3100	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Mdv-3100 inhibits the expression of ABCC4			[28]
Doxorubicin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Doxorubicin inhibits the expression of ABCC4			[29]
Sunitinib	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sunitinib increases the expression of ABCC4			[30]
Temozolomide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Temozolomide inhibits the expression of ABCC4			[31]
Nefazodone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Nefazodone increases the expression of ABCC4			[32]
Ivermectin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ivermectin inhibits the expression of ABCC4			[33]
Estradiol	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Estradiol increases the expression of ABCC4			[35]
Cyclosporine	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cyclosporine increases the expression of ABCC4			[36]
Tretinoin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tretinoin inhibits the expression of ABCC4			[37]
Etodolac	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Etodolac inhibits the activity of ABCC4			[4]
Chlorothiazide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Chlorothiazide inhibits the activity of ABCC4			[38]
Furosemide	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Furosemide inhibits the activity of ABCC4			[38]
Acetaminophen	9 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Acetaminophen induces the activity of ABCC4			[39], [40]
DT Modulation2	Acetaminophen results in increased expression of ABCC4 mRNA			[69]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Acetaminophen results in increased expression of ABCC4 protein			[69]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Adenosine Triphosphate affects the activity of ABCC4 protein which results in increased transport of Acetaminophen metabolite			[58]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Curcumin co-treated with Acetaminophen results in increased expression of ABCC4 mRNA			[70]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Curcumin co-treated with Acetaminophen results in increased expression of ABCC4 protein			[70]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Acetaminophen results in increased expression of ABCC4 mRNA			[71]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	tanshinone co-treated with Acetaminophen results in increased expression of ABCC4 mRNA			[70]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	tanshinone co-treated with Acetaminophen results in increased expression of ABCC4 protein			[70]
Regulation Mechanism				Transcription Factor Info
Eetuximab	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Eetuximab induces the activity of ABCC4			[41]
Flutamide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Flutamide induces the activity of ABCC4			[42]
Drug Marketed but not Approved by US FDA
Rotenone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Rotenone increases the expression of ABCC4			[34]
Drug in Phase 4 Trial
Dihydrotestosterone	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Dihydrotestosterone induces the activity of ABCC4			[62]
Drug in Phase 3 Trial
Oltipraz	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Oltipraz increases the expression of ABCC4			[43]
Drug in Phase 2 Trial
Bisphenol A	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Bisphenol A increases the expression of ABCC4			[45]
Regulation Mechanism	via enhancement of Nuclear factor erythroid 2-related factor 2 (NFE2L2)			Transcription Factor Info
Cell System	Human fetal liver samples
MS-275	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	MS-275 increases the expression of ABCC4			[54]
Drug in Phase 1 Trial
Tetradecanoylphorbol Acetate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tetradecanoylphorbol Acetate inhibits the expression of ABCC4			[19]
TAK-875	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	TAK-875 inhibits the activity of ABCC4			[55]
Adenosine Triphosphate	14 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Adenosine Triphosphate affects the activity of ABCC4			[58]
Sodium arsenite	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sodium arsenite increases the expression of ABCC4			[59]
Drug in Preclinical Test
(+)-JQ1	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	(+)-JQ1 inhibits the expression of ABCC4			[48]
Discontinued Drug
MK-571	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	MK-571 inhibits the transportation of 9-(2-Phosphonomethoxyethyl)adenine by ABCC4 (IC50 = 10 microM)			[1]
Affected Drug/Substrate	9-(2-Phosphonomethoxyethyl)adenine	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MRP4
DT Modulation2	MK-571 inhibits the transportation of Cholyltaurine by ABCC4 (IC50 = 2 microM)			[2]
Affected Drug/Substrate	Cholyltaurine	Modulation Type	Inhibition
Cell System	Chinese hamster lung fibroblasts V79 cells (V79)-MRP4
Trequinsin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Trequinsin inhibits the transportation of 9-(2-Phosphonomethoxyethyl)adenine by ABCC4 (IC50 = 10 microM)			[1]
Affected Drug/Substrate	9-(2-Phosphonomethoxyethyl)adenine	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MRP4
Zaprinast	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Zaprinast inhibits the transportation of 9-(2-Phosphonomethoxyethyl)adenine by ABCC4 (IC50 = 250 microM)			[1]
Affected Drug/Substrate	9-(2-Phosphonomethoxyethyl)adenine	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MRP4
Valspodar	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Valspodar inhibits the transportation of Methotrexate by ABCC4			[7]
Affected Drug/Substrate	Methotrexate	Modulation Type	Inhibition
Cell System	Spodoptera frugiperda (Sf9) cells-MRP4
Investigative Drug
Dilazep	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Dilazep inhibits the transportation of 9-(2-Phosphonomethoxyethyl)adenine by ABCC4 (IC50 = 20 microM)			[1]
Affected Drug/Substrate	9-(2-Phosphonomethoxyethyl)adenine	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MRP4
Metribolone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Metribolone increases the expression of ABCC4			[46]
Phenylmercuric Acetate	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Phenylmercuric Acetate inhibits the expression of ABCC4			[53]
Patented Pharmaceutical Agent
HSDB-595	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	HSDB-595 inhibits the expression of ABCC4			[49]
GSK-J4	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	GSK-J4 inhibits the expression of ABCC4			[56]
Drug Withdrawn
Rimonabant	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Rimonabant inhibits the transportation of Estradiol 17b-D-glucuronide by ABCC4			[16]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MRP4
Natural Product
DT Modulation1	ABCC4 protein results in decreased susceptibility to Quercetin			[15]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Mefloquine inhibits the reaction Quercetin results in increased activity of ABCC4 protein			[64]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Quercetin affects the reaction ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate			[15]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Quercetin inhibits the reaction ABCC4 protein results in decreased susceptibility to Thioguanine			[15]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Quercetin inhibits the reaction ABCC4 protein results in increased export of Cyclic GMP			[15]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Quercetin inhibits the reaction Alprostadil promotes the reaction ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate			[15]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	Quercetin results in decreased expression of ABCC4 mRNA			[47]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	Quercetin results in decreased expression of ABCC4 protein			[47]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	verlukast inhibits the reaction Quercetin results in increased activity of ABCC4 protein			[64]
Regulation Mechanism				Transcription Factor Info
Plant polyphenols	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Plant polyphenols inhibits the transportation of [3H]-dinitrophenyl S-glutathione by ABCC4			[15]
Affected Drug/Substrate	[3H]-dinitrophenyl S-glutathione	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MRP4
Silymarin	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Silymarin inhibits the transportation of Cyclic guanosine monophosphate by ABCC4			[15]
Affected Drug/Substrate	Cyclic guanosine monophosphate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MRP4
6-bromoindirubin-3'-oxime	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	6-bromoindirubin-3'-oxime increases the expression of ABCC4			[47]
Quercitrin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Quercitrin inhibits the expression of ABCC4			[52]
Deguelin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Deguelin increases the expression of ABCC4			[34]
Tobacco Smoke Pollution	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tobacco Smoke Pollution increases the expression of ABCC4			[61]
Caffeine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Caffeine results in increased phosphorylation of ABCC4 protein			[86]
Regulation Mechanism				Transcription Factor Info
Curcumin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Curcumin co-treated with Acetaminophen results in increased expression of ABCC4 mRNA			[70]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Curcumin co-treated with Acetaminophen results in increased expression of ABCC4 protein			[70]
Regulation Mechanism				Transcription Factor Info
Resveratrol	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCC4 protein results in decreased susceptibility to Resveratrol			[15]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Resveratrol inhibits the reaction ABCC4 protein results in increased export of Cyclic GMP			[15]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Resveratrol promotes the reaction ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate			[15]
Regulation Mechanism				Transcription Factor Info
Environmental toxicant
Polychlorinated dibenzodioxin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Polychlorinated dibenzodioxin increases the expression of ABCC4			[44]
Regulation Mechanism	via enhancement of Aryl hydrocarbon receptor (AHR)			Transcription Factor Info
Cell System	Human lung adenocarcinoma cells (H358)
Tetrabromobisphenol A	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tetrabromobisphenol A inhibits the activity of ABCC4			[51]
Mycotoxins
Aflatoxin M1	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Aflatoxin M1 inhibits the expression of ABCC4			[57]
Aflatoxin B1	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Aflatoxin B1 results in decreased methylation of ABCC4 intron			[74]
Regulation Mechanism				Transcription Factor Info
Carcinogen
DT Modulation1	ABCC4 protein results in increased transport of Arsenic			[78]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Arsenic affects the methylation of ABCC4 gene			[79]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	oltipraz promotes the reaction ABCC4 protein results in increased transport of Arsenic			[78]
Regulation Mechanism				Transcription Factor Info
Methylcholanthrene	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Methylcholanthrene increases the expression of ABCC4			[43]
Regulation Mechanism	via enhancement of Aryl hydrocarbon receptor (AHR)			Transcription Factor Info
Cell System	Human hepatoblastoma cells (HepG2)
Ethyl Methanesulfonate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ethyl Methanesulfonate inhibits the expression of ABCC4			[50]
Benzo(a)pyrene	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Benzo(a)pyrene inhibits the expression of ABCC4			[60]
Health and Environmental Toxicant
Perfluorooctane sulfonic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Perfluorooctane sulfonic acid inhibits the activity of ABCC4			[51]

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120	Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach. Arch Toxicol. 2013 Jan;87(1):123-43.

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