Detail Information of Exogenous Modulation

General Information of Drug Transporter (DT)
DT ID	DTD0014 Transporter Info
Gene Name	ABCB11
Transporter Name	Bile salt export pump
Gene ID	8647
UniProt ID	O95342

Exogenous factors (drugs, dietary constituents, etc.) Modulation of This DT (EGM)
Chemical Compound
DT Modulation1	Cyclosporine inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Cyclosporine inhibits the reaction ABCB11 protein results in increased transport of Taurodeoxycholic Acid			[68]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Cyclosporine results in decreased activity of ABCB11 protein			[3]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Cyclosporine results in decreased expression of ABCB11 mRNA			[89]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Glyburide inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Glyburide results in decreased activity of ABCB11 protein			[38]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Glyburide results in decreased activity of ABCB11 protein which results in decreased export of Taurodeoxycholic Acid			[94]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Enzymes and Coenzymes promotes the reaction Troglitazone inhibits the reaction ABCB11 protein results in increased transport of Taurodeoxycholic Acid			[68]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Troglitazone inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Troglitazone inhibits the reaction ABCB11 protein results in increased transport of Taurodeoxycholic Acid			[68]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Troglitazone results in decreased activity of ABCB11 protein			[94]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Troglitazone results in decreased activity of ABCB11 protein which results in decreased export of Taurodeoxycholic Acid			[94]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Troglitazone results in decreased expression of ABCB11			[112]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Progesterone inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Progesterone results in decreased activity of ABCB11 protein			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Clofazimine results in decreased activity of ABCB11 protein			[21]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Reserpine inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Reserpine results in decreased activity of ABCB11 protein			[21]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Valinomycin results in decreased activity of ABCB11 protein			[3]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol affects the expression of ABCB11 protein			[92]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Rifampin inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Rifampin results in decreased activity of ABCB11 protein			[21]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Tamoxifen results in decreased activity of ABCB11 protein			[3]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Bezafibrate affects the localization of ABCB11 protein			[18]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Bezafibrate results in increased expression of ABCB11 mRNA			[18]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Phenobarbital results in increased expression of ABCB11 mRNA			[104]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Clofibrate results in decreased activity of ABCB11 protein			[21]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Dicloxacillin results in decreased activity of ABCB11 protein			[21]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Finasteride results in decreased activity of ABCB11 protein			[21]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Mibefradil results in decreased activity of ABCB11 protein			[21]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Omeprazole results in decreased activity of ABCB11 protein			[21]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Primaquine results in decreased activity of ABCB11 protein			[21]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Sorafenib results in decreased activity of ABCB11 protein			[21]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Tolcapone results in decreased activity of ABCB11 protein			[21]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Etoricoxib results in decreased activity of ABCB11 protein			[21]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Clozapine results in decreased activity of ABCB11 protein			[24]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Olanzapine results in decreased activity of ABCB11 protein			[24]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Ticlopidine results in decreased activity of ABCB11 protein			[24]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Cisapride results in decreased activity of ABCB11 protein			[25]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Danazol results in decreased activity of ABCB11 protein			[25]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Dasatinib results in decreased activity of ABCB11 protein			[25]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Everolimus results in decreased activity of ABCB11 protein			[25]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Irbesartan results in decreased activity of ABCB11 protein			[25]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Medroxyprogesterone Acetate results in decreased activity of ABCB11 protein			[25]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Megestrol Acetate results in decreased activity of ABCB11 protein			[25]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	pimecrolimus results in decreased activity of ABCB11 protein			[25]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Tacrolimus results in decreased activity of ABCB11 protein			[25]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Atropine inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Atropine results in decreased activity of ABCB11 protein			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Cefaclor inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Cefaclor results in decreased activity of ABCB11 protein			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Cholic Acid inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Cholic Acid results in decreased activity of ABCB11 protein			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Cholic Acid results in increased expression of ABCB11 mRNA			[88]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Clarithromycin inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Clarithromycin results in decreased activity of ABCB11 protein			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Clotrimazole inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Clotrimazole results in decreased activity of ABCB11 protein			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Diethylstilbestrol inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Diethylstilbestrol results in decreased activity of ABCB11 protein			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Erythromycin inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Erythromycin results in decreased activity of ABCB11 protein			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Ezetimibe inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Ezetimibe results in decreased activity of ABCB11 protein			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Felodipine inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Felodipine results in decreased activity of ABCB11 protein			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Fluvoxamine inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Fluvoxamine results in decreased activity of ABCB11 protein			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Glipizide inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Glipizide results in decreased activity of ABCB11 protein			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Isradipine inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Isradipine results in decreased activity of ABCB11 protein			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Naproxen inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Naproxen results in decreased activity of ABCB11 protein			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Nifedipine inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Nifedipine results in decreased activity of ABCB11 protein			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Nitrofurantoin inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Nitrofurantoin results in decreased activity of ABCB11 protein			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Ofloxacin inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Ofloxacin results in decreased activity of ABCB11 protein			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Ranolazine inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Ranolazine results in decreased activity of ABCB11 protein			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Spironolactone inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Spironolactone results in decreased activity of ABCB11 protein			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Sulfinpyrazone inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Sulfinpyrazone results in decreased activity of ABCB11 protein			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Tinidazole inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Tinidazole results in decreased activity of ABCB11 protein			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Vinblastine inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Vinblastine results in decreased activity of ABCB11 protein			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Floxacillin inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Floxacillin results in decreased activity of ABCB11 protein			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Tolvaptan metabolite results in decreased activity of ABCB11 protein			[27]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Tolvaptan results in decreased activity of ABCB11 protein			[25]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Ethinyl Estradiol co-treated with Cholic Acids affects the expression of ABCB11 mRNA			[61]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Ethinyl Estradiol results in decreased activity of ABCB11 protein			[21]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	PRKACA protein affects the reaction Ethinyl Estradiol results in decreased expression of ABCB11 mRNA			[28]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	PRKACB protein affects the reaction Ethinyl Estradiol results in decreased expression of ABCB11 mRNA			[28]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Dihydroergotamine results in decreased activity of ABCB11 protein			[29]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Primidone results in decreased activity of ABCB11 protein			[29]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Valproic Acid results in decreased activity of ABCB11 protein			[66]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Valproic Acid results in decreased methylation of ABCB11 gene			[113]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Pioglitazone results in decreased activity of ABCB11 protein			[21]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Rosiglitazone inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Rosiglitazone results in decreased activity of ABCB11 protein			[21]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Ritonavir inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Ritonavir results in decreased activity of ABCB11 protein			[21]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Indomethacin inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Indomethacin results in decreased activity of ABCB11 protein			[21]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Gefitinib results in decreased activity of ABCB11 protein			[21]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Paclitaxel results in decreased activity of ABCB11 protein			[21]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Fenofibrate inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Fenofibrate results in decreased activity of ABCB11 protein			[21]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Lopinavir inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Lopinavir results in decreased activity of ABCB11 protein			[21]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Nelfinavir inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Nelfinavir results in decreased activity of ABCB11 protein			[21]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Nicardipine inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Nicardipine results in decreased activity of ABCB11 protein			[21]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Saquinavir inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Saquinavir results in decreased activity of ABCB11 protein			[21]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Simvastatin inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Simvastatin results in decreased activity of ABCB11 protein			[21]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Telmisartan inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Telmisartan results in decreased activity of ABCB11 protein			[21]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Indinavir inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Indinavir results in decreased activity of ABCB11 protein			[21]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Benzbromarone inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Benzbromarone results in decreased activity of ABCB11 protein			[21]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Lapatinib results in decreased activity of ABCB11 protein			[21]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Amiodarone inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Amiodarone results in decreased activity of ABCB11 protein			[21]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Imatinib Mesylate inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Imatinib Mesylate results in decreased activity of ABCB11 protein			[21]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Midazolam inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Midazolam results in decreased activity of ABCB11 protein			[21]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Nitrendipine inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Nitrendipine results in decreased activity of ABCB11 protein			[21]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Celecoxib inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Celecoxib results in decreased activity of ABCB11 protein			[24]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Dipyridamole inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Dipyridamole results in decreased activity of ABCB11 protein			[25]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Losartan inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Losartan results in decreased activity of ABCB11 protein			[25]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Lovastatin inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Lovastatin results in decreased activity of ABCB11 protein			[25]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Mifepristone inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Mifepristone results in decreased activity of ABCB11 protein			[25]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Loratadine inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Loratadine results in decreased activity of ABCB11 protein			[25]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Diclofenac inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Diclofenac results in decreased activity of ABCB11 protein			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Atenolol inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Atenolol results in decreased activity of ABCB11 protein			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Budesonide inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Budesonide results in decreased activity of ABCB11 protein			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Disulfiram inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Disulfiram results in decreased activity of ABCB11 protein			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Fluvastatin inhibits the reaction ABCB11 protein affects the import of Taurocholic Acid			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Fluvastatin results in decreased activity of ABCB11 protein			[21]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	ABCB11 protein affects the import of Pravastatin			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Pravastatin inhibits the reaction ABCB11 protein affects the import of Taurocholic Acid			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Pravastatin results in decreased activity of ABCB11 protein			[66]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Bosentan inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Bosentan results in decreased activity of ABCB11 protein			[21]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Bosentan results in decreased expression of ABCB11 mRNA			[77]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Cloxacillin results in decreased activity of ABCB11 protein			[38]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Itraconazole results in decreased activity of ABCB11 protein			[21]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Ketoconazole inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Ketoconazole results in decreased activity of ABCB11 protein			[94]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Ketoconazole results in decreased activity of ABCB11 protein which results in decreased export of Taurodeoxycholic Acid			[94]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Lithocholic Acid analog binds to and results in increased activity of NR1H4 protein which results in increased expression of ABCB11 mRNA			[82]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Lithocholic Acid binds to and results in increased activity of NR1H4 protein which results in increased expression of ABCB11 mRNA			[82]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Lithocholic Acid results in decreased expression of ABCB11 protein			[62]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Glycyrrhizic Acid inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Glycyrrhizic Acid results in decreased activity of ABCB11 protein			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Astemizole inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Astemizole results in decreased activity of ABCB11 protein			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Terfenadine inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Terfenadine results in decreased activity of ABCB11 protein			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	TAK-875 analog results in decreased activity of ABCB11 protein			[53]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	TAK-875 inhibits the reaction ABCB11 protein results in increased transport of Bile Acids and Salts			[108]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	TAK-875 metabolite results in decreased activity of ABCB11 protein			[109]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	TAK-875 results in decreased activity of ABCB11 protein			[108]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Benzo(a)pyrene results in increased methylation of ABCB11 5' UTR			[74]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Benzo(a)pyrene results in increased methylation of ABCB11 promoter			[74]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Benzo(a)pyrene results in increased mutagenesis of ABCB11 gene			[75]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Ethanol results in increased expression of ABCB11 mRNA			[59]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Cinnarizine results in decreased activity of ABCB11 protein			[21]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Fusidic Acid inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Fusidic Acid results in decreased activity of ABCB11 protein			[21]
Regulation Mechanism				Transcription Factor Info
1-Naphthylisothiocyanate	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	1-Naphthylisothiocyanate co-treated with Cholic Acids affects the expression of ABCB11 mRNA			[61]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	1-Naphthylisothiocyanate results in decreased expression of ABCB11 protein			[62]
Regulation Mechanism				Transcription Factor Info
2,2',3',4,4',5-hexachlorobiphenyl	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	2,2',3',4,4',5-hexachlorobiphenyl affects the expression of ABCB11 mRNA			[63]
Regulation Mechanism				Transcription Factor Info
2-methoxy-N-(3-(4-((3-methyl-4-((6-methyl-3-pyridinyl)oxy)phenyl)amino)-6-quinazolinyl)-2-propenyl)acetamide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	2-methoxy-N-(3-(4-((3-methyl-4-((6-methyl-3-pyridinyl)oxy)phenyl)amino)-6-quinazolinyl)-2-propenyl)acetamide inhibits the reaction ABCB11 protein results in increased import of Taurocholic Acid			[64]
Regulation Mechanism				Transcription Factor Info
3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester results in decreased activity of ABCB11 protein			[26]
Regulation Mechanism				Transcription Factor Info
4,4-difluoro-4-bora-3a,4a-diaza-s-indacene	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCB11 protein affects the transport of 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene			[3]
Regulation Mechanism				Transcription Factor Info
7-hydroxytheonellasterol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	7-hydroxytheonellasterol inhibits the reaction Chenodeoxycholic Acid results in increased expression of ABCB11 mRNA			[65]
Regulation Mechanism				Transcription Factor Info
Aconitine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Aconitine inhibits the reaction ABCB11 protein results in increased transport of Taurodeoxycholic Acid			[68]
Regulation Mechanism				Transcription Factor Info
Adenosine Triphosphate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Adenosine Triphosphate promotes the reaction ABCB11 protein results in increased uptake of fexofenadine			[69]
Regulation Mechanism				Transcription Factor Info
Albuterol	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Albuterol results in increased expression of ABCB11 mRNA			[71]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Carvedilol inhibits the reaction Albuterol results in increased expression of ABCB11 mRNA			[71]
Regulation Mechanism				Transcription Factor Info
alisol B 23-acetate	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	alisol B 23-acetate results in increased expression of ABCB11 protein			[72]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	pregna-4,17-diene-3,16-dione inhibits the reaction alisol B 23-acetate results in increased expression of ABCB11 protein			[72]
Regulation Mechanism				Transcription Factor Info
alpha-Linolenic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	alpha-Linolenic Acid promotes the reaction GW 4064 results in increased expression of ABCB11 mRNA			[73]
Regulation Mechanism				Transcription Factor Info
AMG 009	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	AMG 009 results in decreased activity of ABCB11 protein			[25]
Regulation Mechanism				Transcription Factor Info
Amoxicillin-Potassium Clavulanate Combination	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Amoxicillin-Potassium Clavulanate Combination results in decreased expression of ABCB11 mRNA			[32]
Regulation Mechanism				Transcription Factor Info
amprenavir	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	amprenavir results in decreased activity of ABCB11 protein			[21]
Regulation Mechanism				Transcription Factor Info
Arachidonic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Arachidonic Acid promotes the reaction GW 4064 results in increased expression of ABCB11 mRNA			[73]
Regulation Mechanism				Transcription Factor Info
Atazanavir Sulfate	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Atazanavir Sulfate inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Atazanavir Sulfate results in decreased activity of ABCB11 protein			[26]
Regulation Mechanism				Transcription Factor Info
aurantio-obtusin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	aurantio-obtusin inhibits the reaction ABCB11 protein results in increased transport of Taurodeoxycholic Acid			[68]
Regulation Mechanism				Transcription Factor Info
baohuoside I	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	baohuoside I results in decreased expression of ABCB11 mRNA			[60]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	baohuoside I results in decreased expression of ABCB11 protein			[60]
Regulation Mechanism				Transcription Factor Info
benziodarone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	benziodarone results in decreased activity of ABCB11 protein			[29]
Regulation Mechanism				Transcription Factor Info
bicalutamide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	bicalutamide results in decreased activity of ABCB11 protein			[29]
Regulation Mechanism				Transcription Factor Info
bisbenzimide ethoxide trihydrochloride	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	bisbenzimide ethoxide trihydrochloride inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	bisbenzimide ethoxide trihydrochloride results in decreased activity of ABCB11 protein			[26]
Regulation Mechanism				Transcription Factor Info
bisphenol A	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	bisphenol A co-treated with Fulvestrant results in increased methylation of ABCB11 gene			[76]
Regulation Mechanism				Transcription Factor Info
bromfenac	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	bromfenac results in decreased activity of ABCB11 protein			[24]
Regulation Mechanism				Transcription Factor Info
Carbamazepine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Carbamazepine results in decreased activity of ABCB11 protein			[66]
Regulation Mechanism				Transcription Factor Info
carboxyatractyloside	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	carboxyatractyloside inhibits the reaction ABCB11 protein results in increased transport of Taurodeoxycholic Acid			[68]
Regulation Mechanism				Transcription Factor Info
Carvedilol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Carvedilol inhibits the reaction Albuterol results in increased expression of ABCB11 mRNA			[71]
Regulation Mechanism				Transcription Factor Info
Catechin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Catechin co-treated with Grape Seed Proanthocyanidins results in increased expression of ABCB11 mRNA			[79]
Regulation Mechanism				Transcription Factor Info
celastrol	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	celastrol inhibits the reaction ABCB11 protein results in increased transport of Taurodeoxycholic Acid			[68]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Enzymes and Coenzymes inhibits the reaction celastrol inhibits the reaction ABCB11 protein results in increased transport of Taurodeoxycholic Acid			[68]
Regulation Mechanism				Transcription Factor Info
cerivastatin	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	cerivastatin inhibits the reaction ABCB11 protein affects the import of Taurocholic Acid			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	cerivastatin inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	cerivastatin results in decreased activity of ABCB11 protein			[26]
Regulation Mechanism				Transcription Factor Info
cetrorelix	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	cetrorelix results in decreased activity of ABCB11 protein			[25]
Regulation Mechanism				Transcription Factor Info
CGP 52608	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	CGP 52608 promotes the reaction RORA protein binds to ABCB11 gene			[80]
Regulation Mechanism				Transcription Factor Info
chelerythrine	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	chelerythrine inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	chelerythrine results in decreased activity of ABCB11 protein			[26]
Regulation Mechanism				Transcription Factor Info
Chenodeoxycholic Acid	14 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	6-hydroxy-5-((p- sulfophenyl)azo)-2-naphthalenesulfonic acid disodium salt co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid results in increased expression of ABCB11 mRNA			[81]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	7-hydroxytheonellasterol inhibits the reaction Chenodeoxycholic Acid results in increased expression of ABCB11 mRNA			[65]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Chenodeoxycholic Acid binds to and results in increased activity of NR1H4 protein which results in increased expression of ABCB11 mRNA			[82]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Chenodeoxycholic Acid results in increased expression of ABCB11 mRNA			[83]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Chenodeoxycholic Acid results in increased expression of ABCB11 protein			[84]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Copper Sulfate inhibits the reaction Chenodeoxycholic Acid results in increased expression of ABCB11 mRNA			[85]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	epigallocatechin gallate inhibits the reaction Chenodeoxycholic Acid results in increased expression of ABCB11 mRNA			[47]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with 6-hydroxy-5-((p- sulfophenyl)azo)-2-naphthalenesulfonic acid disodium salt results in increased expression of ABCB11 mRNA			[67]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Acetaminophen results in decreased expression of ABCB11 mRNA			[67]
Regulation Mechanism				Transcription Factor Info
DT Modulation10	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Triclosan results in increased expression of ABCB11 mRNA			[67]
Regulation Mechanism				Transcription Factor Info
DT Modulation11	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid results in increased expression of ABCB11 mRNA			[86]
Regulation Mechanism				Transcription Factor Info
DT Modulation12	LG 100268 inhibits the reaction Chenodeoxycholic Acid results in increased expression of ABCB11 mRNA			[83]
Regulation Mechanism				Transcription Factor Info
DT Modulation13	pregna-4,17-diene-3,16-dione co-treated with Chenodeoxycholic Acid results in increased expression of ABCB11 mRNA			[87]
Regulation Mechanism				Transcription Factor Info
DT Modulation14	Zinc Sulfate inhibits the reaction Copper Sulfate inhibits the reaction Chenodeoxycholic Acid results in increased expression of ABCB11 mRNA			[85]
Regulation Mechanism				Transcription Factor Info
Chlordiazepoxide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Chlordiazepoxide results in decreased activity of ABCB11 protein			[21]
Regulation Mechanism				Transcription Factor Info
Chlorpromazine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Chlorpromazine co-treated with Cholic Acids affects the expression of ABCB11 mRNA			[61]
Regulation Mechanism				Transcription Factor Info
ciglitazone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ciglitazone results in decreased activity of ABCB11 protein			[21]
Regulation Mechanism				Transcription Factor Info
Cisplatin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cisplatin results in decreased expression of ABCB11 protein			[62]
Regulation Mechanism				Transcription Factor Info
Clavulanic Acid	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Clavulanic Acid inhibits the reaction GW 4064 results in increased expression of ABCB11 mRNA			[32]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Clavulanic Acid results in decreased expression of ABCB11 mRNA			[32]
Regulation Mechanism				Transcription Factor Info
Copper Sulfate	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Copper Sulfate inhibits the reaction Chenodeoxycholic Acid results in increased expression of ABCB11 mRNA			[85]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Zinc Sulfate inhibits the reaction Copper Sulfate inhibits the reaction Chenodeoxycholic Acid results in increased expression of ABCB11 mRNA			[85]
Regulation Mechanism				Transcription Factor Info
cryptotanshinone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	cryptotanshinone inhibits the reaction ABCB11 protein results in increased transport of Taurodeoxycholic Acid			[68]
Regulation Mechanism				Transcription Factor Info
cyproconazole	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	cyproconazole results in decreased expression of ABCB11 mRNA			[90]
Regulation Mechanism				Transcription Factor Info
DEET	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	DEET results in decreased expression of ABCB11 mRNA			[50]
Regulation Mechanism				Transcription Factor Info
Dehydroepiandrosterone Sulfate	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Dehydroepiandrosterone Sulfate inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Dehydroepiandrosterone Sulfate results in decreased activity of ABCB11 protein			[26]
Regulation Mechanism				Transcription Factor Info
Deoxycholic Acid	6 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	6-hydroxy-5-((p- sulfophenyl)azo)-2-naphthalenesulfonic acid disodium salt co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid results in increased expression of ABCB11 mRNA			[81]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Deoxycholic Acid results in increased expression of ABCB11 mRNA			[91]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with 6-hydroxy-5-((p- sulfophenyl)azo)-2-naphthalenesulfonic acid disodium salt results in increased expression of ABCB11 mRNA			[67]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Acetaminophen results in decreased expression of ABCB11 mRNA			[67]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Triclosan results in increased expression of ABCB11 mRNA			[67]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid results in increased expression of ABCB11 mRNA			[86]
Regulation Mechanism				Transcription Factor Info
dihydrotanshinone I	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	dihydrotanshinone I inhibits the reaction ABCB11 protein results in increased transport of Taurodeoxycholic Acid			[68]
Regulation Mechanism				Transcription Factor Info
diosbulbin B	9 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	diosbulbin B metabolite inhibits the reaction ABCB11 protein results in increased transport of Taurodeoxycholic Acid			[68]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	diosbulbin B promotes the reaction ABCB11 protein results in increased transport of Taurodeoxycholic Acid			[68]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	diosbulbin B results in decreased expression of ABCB11 mRNA			[62]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	diosbulbin B results in decreased expression of ABCB11 protein			[62]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Enzymes and Coenzymes inhibits the reaction diosbulbin B promotes the reaction ABCB11 protein results in increased transport of Taurodeoxycholic Acid			[68]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	NADP co-treated with Uridine Diphosphate Glucuronic Acid co-treated with Phosphoadenosine Phosphosulfate promotes the reaction Enzymes and Coenzymes results in increased metabolism of diosbulbin B inhibits the reaction ABCB11 protein results in increased transport of Taurodeoxycholic Acid			[68]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	NADP promotes the reaction Enzymes and Coenzymes results in increased metabolism of diosbulbin B inhibits the reaction ABCB11 protein results in increased transport of Taurodeoxycholic Acid			[68]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	NR1H4 protein inhibits the reaction diosbulbin B results in decreased expression of ABCB11 mRNA			[62]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	NR1H4 protein inhibits the reaction diosbulbin B results in decreased expression of ABCB11 protein			[62]
Regulation Mechanism				Transcription Factor Info
Dobutamine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Dobutamine results in decreased activity of ABCB11 protein			[29]
Regulation Mechanism				Transcription Factor Info
drospirenone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	drospirenone results in decreased activity of ABCB11 protein			[25]
Regulation Mechanism				Transcription Factor Info
drotaverin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	drotaverin results in decreased activity of ABCB11 protein			[21]
Regulation Mechanism				Transcription Factor Info
efavirenz	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	efavirenz inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	efavirenz results in decreased activity of ABCB11 protein			[26]
Regulation Mechanism				Transcription Factor Info
Elacridar	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Elacridar inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Elacridar results in decreased activity of ABCB11 protein			[26]
Regulation Mechanism				Transcription Factor Info
epicatechin gallate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	epicatechin gallate results in increased expression of ABCB11 mRNA			[47]
Regulation Mechanism				Transcription Factor Info
epigallocatechin gallate	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	epigallocatechin gallate inhibits the reaction Chenodeoxycholic Acid results in increased expression of ABCB11 mRNA			[47]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	epigallocatechin gallate inhibits the reaction GW 4064 results in increased expression of ABCB11 mRNA			[47]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	epigallocatechin gallate results in increased expression of ABCB11 mRNA			[47]
Regulation Mechanism				Transcription Factor Info
ergocristine	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ergocristine inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	ergocristine results in decreased activity of ABCB11 protein			[26]
Regulation Mechanism				Transcription Factor Info
Erythromycin Estolate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Erythromycin Estolate results in decreased activity of ABCB11 protein			[21]
Regulation Mechanism				Transcription Factor Info
Ethambutol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol affects the expression of ABCB11 protein			[92]
Regulation Mechanism				Transcription Factor Info
fexofenadine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Adenosine Triphosphate promotes the reaction ABCB11 protein results in increased uptake of fexofenadine			[69]
Regulation Mechanism				Transcription Factor Info
fipexide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	fipexide results in decreased activity of ABCB11 protein			[29]
Regulation Mechanism				Transcription Factor Info
flupirtine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	flupirtine results in decreased activity of ABCB11 protein			[21]
Regulation Mechanism				Transcription Factor Info
Fulvestrant	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	bisphenol A co-treated with Fulvestrant results in increased methylation of ABCB11 gene			[76]
Regulation Mechanism				Transcription Factor Info
Furosemide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Furosemide results in decreased activity of ABCB11 protein			[66]
Regulation Mechanism				Transcription Factor Info
gallocatechol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	gallocatechol results in increased expression of ABCB11 mRNA			[47]
Regulation Mechanism				Transcription Factor Info
ginsenoside Re	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCB11 protein results in increased transport of ginsenoside Re			[93]
Regulation Mechanism				Transcription Factor Info
ginsenoside Rg1	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCB11 protein results in increased transport of ginsenoside Rg1			[93]
Regulation Mechanism				Transcription Factor Info
glimepiride	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	glimepiride inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	glimepiride results in decreased activity of ABCB11 protein			[21]
Regulation Mechanism				Transcription Factor Info
gliquidone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	gliquidone results in decreased activity of ABCB11 protein			[25]
Regulation Mechanism				Transcription Factor Info
Glycochenodeoxycholic Acid	5 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	6-hydroxy-5-((p- sulfophenyl)azo)-2-naphthalenesulfonic acid disodium salt co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid results in increased expression of ABCB11 mRNA			[81]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with 6-hydroxy-5-((p- sulfophenyl)azo)-2-naphthalenesulfonic acid disodium salt results in increased expression of ABCB11 mRNA			[67]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Acetaminophen results in decreased expression of ABCB11 mRNA			[67]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Triclosan results in increased expression of ABCB11 mRNA			[67]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid results in increased expression of ABCB11 mRNA			[86]
Regulation Mechanism				Transcription Factor Info
Glycocholic Acid	6 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	6-hydroxy-5-((p- sulfophenyl)azo)-2-naphthalenesulfonic acid disodium salt co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid results in increased expression of ABCB11 mRNA			[81]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	ABCB11 protein affects the transport of Glycocholic Acid			[95]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with 6-hydroxy-5-((p- sulfophenyl)azo)-2-naphthalenesulfonic acid disodium salt results in increased expression of ABCB11 mRNA			[67]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Acetaminophen results in decreased expression of ABCB11 mRNA			[67]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Triclosan results in increased expression of ABCB11 mRNA			[67]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid results in increased expression of ABCB11 mRNA			[86]
Regulation Mechanism				Transcription Factor Info
Glycodeoxycholic Acid	5 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	6-hydroxy-5-((p- sulfophenyl)azo)-2-naphthalenesulfonic acid disodium salt co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid results in increased expression of ABCB11 mRNA			[81]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with 6-hydroxy-5-((p- sulfophenyl)azo)-2-naphthalenesulfonic acid disodium salt results in increased expression of ABCB11 mRNA			[67]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Acetaminophen results in decreased expression of ABCB11 mRNA			[67]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Triclosan results in increased expression of ABCB11 mRNA			[67]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid results in increased expression of ABCB11 mRNA			[86]
Regulation Mechanism				Transcription Factor Info
GW 4064	9 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	alpha-Linolenic Acid promotes the reaction GW 4064 results in increased expression of ABCB11 mRNA			[73]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Arachidonic Acid promotes the reaction GW 4064 results in increased expression of ABCB11 mRNA			[73]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Clavulanic Acid inhibits the reaction GW 4064 results in increased expression of ABCB11 mRNA			[32]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Docosahexaenoic Acids promotes the reaction GW 4064 results in increased expression of ABCB11 mRNA			[73]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	epigallocatechin gallate inhibits the reaction GW 4064 results in increased expression of ABCB11 mRNA			[47]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	GW 4064 results in increased expression of ABCB11 mRNA			[83]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	LG 100268 inhibits the reaction GW 4064 results in increased expression of ABCB11 mRNA			[83]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	pregna-4,17-diene-3,16-dione co-treated with GW 4064 results in increased expression of ABCB11 mRNA			[87]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	pregna-4,17-diene-3,16-dione inhibits the reaction GW 4064 results in increased expression of ABCB11 mRNA			[32]
Regulation Mechanism				Transcription Factor Info
heliotrine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	heliotrine results in decreased expression of ABCB11 mRNA			[49]
Regulation Mechanism				Transcription Factor Info
iloperidone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	iloperidone results in decreased activity of ABCB11 protein			[25]
Regulation Mechanism				Transcription Factor Info
Indocyanine Green	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Indocyanine Green inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Indocyanine Green results in decreased activity of ABCB11 protein			[26]
Regulation Mechanism				Transcription Factor Info
isobavachalcone	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Enzymes and Coenzymes inhibits the reaction isobavachalcone inhibits the reaction ABCB11 protein results in increased transport of Taurodeoxycholic Acid			[68]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	isobavachalcone inhibits the reaction ABCB11 protein results in increased transport of Taurodeoxycholic Acid			[68]
Regulation Mechanism				Transcription Factor Info
Isoniazid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol affects the expression of ABCB11 protein			[92]
Regulation Mechanism				Transcription Factor Info
kansuinin A	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	kansuinin A inhibits the reaction ABCB11 protein results in increased transport of Taurodeoxycholic Acid			[68]
Regulation Mechanism				Transcription Factor Info
kansuinin B	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	kansuinin B inhibits the reaction ABCB11 protein results in increased transport of Taurodeoxycholic Acid			[68]
Regulation Mechanism				Transcription Factor Info
Kynurenic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Kynurenic Acid inhibits the reaction ABCB11 protein results in increased uptake of Taurocholic Acid			[96]
Regulation Mechanism				Transcription Factor Info
lasiocarpine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	lasiocarpine results in decreased expression of ABCB11 mRNA			[58]
Regulation Mechanism				Transcription Factor Info
Latanoprost	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Latanoprost results in decreased activity of ABCB11 protein			[25]
Regulation Mechanism				Transcription Factor Info
LG 100268	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	LG 100268 inhibits the reaction Chenodeoxycholic Acid results in increased expression of ABCB11 mRNA			[83]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	LG 100268 inhibits the reaction GW 4064 results in increased expression of ABCB11 mRNA			[83]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	LG 100268 inhibits the reaction NR1H4 protein binds to RXRA protein which binds to ABCB11 promoter			[83]
Regulation Mechanism				Transcription Factor Info
mesaconitine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	mesaconitine inhibits the reaction ABCB11 protein results in increased transport of Taurodeoxycholic Acid			[68]
Regulation Mechanism				Transcription Factor Info
Methapyrilene	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Methapyrilene results in decreased expression of ABCB11 mRNA			[97]
Regulation Mechanism				Transcription Factor Info
methyleugenol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	methyleugenol results in decreased expression of ABCB11 mRNA			[58]
Regulation Mechanism				Transcription Factor Info
Methyltestosterone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Methyltestosterone co-treated with Cholic Acids affects the expression of ABCB11 mRNA			[61]
Regulation Mechanism				Transcription Factor Info
midecamycin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	midecamycin results in decreased activity of ABCB11 protein			[38]
Regulation Mechanism				Transcription Factor Info
morin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	morin inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	morin results in decreased activity of ABCB11 protein			[26]
Regulation Mechanism				Transcription Factor Info
NADP	6 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	NADP co-treated with Uridine Diphosphate Glucuronic Acid co-treated with Phosphoadenosine Phosphosulfate promotes the reaction Enzymes and Coenzymes results in increased metabolism of diosbulbin B inhibits the reaction ABCB11 protein results in increased transport of Taurodeoxycholic Acid			[68]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	NADP co-treated with Uridine Diphosphate Glucuronic Acid co-treated with Phosphoadenosine Phosphosulfate promotes the reaction Enzymes and Coenzymes results in increased metabolism of saikogenin A analog inhibits the reaction ABCB11 protein results in increased transport of Taurodeoxycholic Acid			[68]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	NADP co-treated with Uridine Diphosphate Glucuronic Acid co-treated with Phosphoadenosine Phosphosulfate promotes the reaction Enzymes and Coenzymes results in increased metabolism of saikogenin A inhibits the reaction ABCB11 protein results in increased transport of Taurodeoxycholic Acid			[68]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	NADP promotes the reaction Enzymes and Coenzymes results in increased metabolism of diosbulbin B inhibits the reaction ABCB11 protein results in increased transport of Taurodeoxycholic Acid			[68]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	NADP promotes the reaction Enzymes and Coenzymes results in increased metabolism of saikogenin A analog inhibits the reaction ABCB11 protein results in increased transport of Taurodeoxycholic Acid			[68]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	NADP promotes the reaction Enzymes and Coenzymes results in increased metabolism of saikogenin A inhibits the reaction ABCB11 protein results in increased transport of Taurodeoxycholic Acid			[68]
Regulation Mechanism				Transcription Factor Info
nefazodone	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	nefazodone inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	nefazodone results in decreased activity of ABCB11 protein			[98]
Regulation Mechanism				Transcription Factor Info
neratinib	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	neratinib results in decreased activity of ABCB11 protein			[25]
Regulation Mechanism				Transcription Factor Info
Norethindrone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Norethindrone results in decreased activity of ABCB11 protein			[21]
Regulation Mechanism				Transcription Factor Info
notoginsenoside R1	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCB11 protein results in increased transport of notoginsenoside R1			[93]
Regulation Mechanism				Transcription Factor Info
obeticholic acid	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	obeticholic acid promotes the reaction PRMT1 protein binds to ABCB11 promoter			[99]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	obeticholic acid results in increased expression of ABCB11 mRNA			[99]
Regulation Mechanism				Transcription Factor Info
Octreotide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Octreotide results in decreased activity of ABCB11 protein			[25]
Regulation Mechanism				Transcription Factor Info
Okadaic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Okadaic Acid results in decreased expression of ABCB11 mRNA			[100]
Regulation Mechanism				Transcription Factor Info
olmesartan	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	olmesartan inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	olmesartan results in decreased activity of ABCB11 protein			[26]
Regulation Mechanism				Transcription Factor Info
Olmesartan Medoxomil	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Olmesartan Medoxomil results in decreased activity of ABCB11 protein			[25]
Regulation Mechanism				Transcription Factor Info
oltipraz	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	oltipraz results in decreased expression of ABCB11 mRNA			[19]
Regulation Mechanism				Transcription Factor Info
oxybutynin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	oxybutynin results in decreased activity of ABCB11 protein			[21]
Regulation Mechanism				Transcription Factor Info
pazopanib	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	pazopanib results in decreased activity of ABCB11 protein			[21]
Regulation Mechanism				Transcription Factor Info
perfluorooctanesulfonamide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	perfluorooctanesulfonamide results in decreased expression of ABCB11 mRNA			[90]
Regulation Mechanism				Transcription Factor Info
perfluorooctane sulfonic acid	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	perfluorooctane sulfonic acid affects the expression of ABCB11 mRNA			[102]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	perfluorooctane sulfonic acid results in decreased expression of ABCB11 mRNA			[51]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	perfluorooctane sulfonic acid results in increased expression of ABCB11 mRNA			[103]
Regulation Mechanism				Transcription Factor Info
perfluorooctanoic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	perfluorooctanoic acid results in decreased expression of ABCB11 mRNA			[51]
Regulation Mechanism				Transcription Factor Info
Phosphoadenosine Phosphosulfate	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	NADP co-treated with Uridine Diphosphate Glucuronic Acid co-treated with Phosphoadenosine Phosphosulfate promotes the reaction Enzymes and Coenzymes results in increased metabolism of diosbulbin B inhibits the reaction ABCB11 protein results in increased transport of Taurodeoxycholic Acid			[68]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	NADP co-treated with Uridine Diphosphate Glucuronic Acid co-treated with Phosphoadenosine Phosphosulfate promotes the reaction Enzymes and Coenzymes results in increased metabolism of saikogenin A analog inhibits the reaction ABCB11 protein results in increased transport of Taurodeoxycholic Acid			[68]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	NADP co-treated with Uridine Diphosphate Glucuronic Acid co-treated with Phosphoadenosine Phosphosulfate promotes the reaction Enzymes and Coenzymes results in increased metabolism of saikogenin A inhibits the reaction ABCB11 protein results in increased transport of Taurodeoxycholic Acid			[68]
Regulation Mechanism				Transcription Factor Info
pilsicainide	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	pilsicainide inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	pilsicainide results in decreased activity of ABCB11 protein			[26]
Regulation Mechanism				Transcription Factor Info
pirinixic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	pirinixic acid results in decreased activity of ABCB11 protein			[21]
Regulation Mechanism				Transcription Factor Info
pitavastatin	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	pitavastatin inhibits the reaction ABCB11 protein affects the import of Taurocholic Acid			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	pitavastatin inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	pitavastatin results in decreased activity of ABCB11 protein			[26]
Regulation Mechanism				Transcription Factor Info
posaconazole	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	posaconazole results in decreased activity of ABCB11 protein			[25]
Regulation Mechanism				Transcription Factor Info
pranlukast	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	pranlukast results in decreased activity of ABCB11 protein			[25]
Regulation Mechanism				Transcription Factor Info
pregna-4,17-diene-3,16-dione	7 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	pregna-4,17-diene-3,16-dione co-treated with Chenodeoxycholic Acid results in increased expression of ABCB11 mRNA			[87]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	pregna-4,17-diene-3,16-dione co-treated with GW 4064 results in increased expression of ABCB11 mRNA			[87]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	pregna-4,17-diene-3,16-dione inhibits the reaction alisol B 23-acetate results in increased expression of ABCB11 protein			[72]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	pregna-4,17-diene-3,16-dione inhibits the reaction Bile Acids and Salts results in increased expression of ABCB11 mRNA			[105]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	pregna-4,17-diene-3,16-dione inhibits the reaction GW 4064 results in increased expression of ABCB11 mRNA			[32]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	pregna-4,17-diene-3,16-dione inhibits the reaction NR1H4 protein results in increased expression of ABCB11 mRNA			[105]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	pregna-4,17-diene-3,16-dione results in increased expression of ABCB11 mRNA			[87]
Regulation Mechanism				Transcription Factor Info
propiconazole	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	propiconazole results in decreased activity of ABCB11 protein			[106]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	propiconazole results in decreased expression of ABCB11 mRNA			[106]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	tebuconazole promotes the reaction propiconazole results in decreased expression of ABCB11 mRNA			[106]
Regulation Mechanism				Transcription Factor Info
Pyrazinamide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol affects the expression of ABCB11 protein			[92]
Regulation Mechanism				Transcription Factor Info
repaglinide	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	repaglinide inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	repaglinide results in decreased activity of ABCB11 protein			[25]
Regulation Mechanism				Transcription Factor Info
rhein	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Enzymes and Coenzymes inhibits the reaction rhein promotes the reaction ABCB11 protein results in increased transport of Taurodeoxycholic Acid			[68]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	rhein metabolite inhibits the reaction ABCB11 protein results in increased transport of Taurodeoxycholic Acid			[68]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	rhein promotes the reaction ABCB11 protein results in increased transport of Taurodeoxycholic Acid			[68]
Regulation Mechanism				Transcription Factor Info
Rifabutin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Rifabutin results in decreased activity of ABCB11 protein			[21]
Regulation Mechanism				Transcription Factor Info
rifapentine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	rifapentine results in decreased activity of ABCB11 protein			[25]
Regulation Mechanism				Transcription Factor Info
Rosuvastatin Calcium	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Rosuvastatin Calcium inhibits the reaction ABCB11 protein affects the import of Taurocholic Acid			[9]
Regulation Mechanism				Transcription Factor Info
saikogenin A	8 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Enzymes and Coenzymes promotes the reaction saikogenin A analog inhibits the reaction ABCB11 protein results in increased transport of Taurodeoxycholic Acid			[68]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Enzymes and Coenzymes promotes the reaction saikogenin A inhibits the reaction ABCB11 protein results in increased transport of Taurodeoxycholic Acid			[68]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	NADP co-treated with Uridine Diphosphate Glucuronic Acid co-treated with Phosphoadenosine Phosphosulfate promotes the reaction Enzymes and Coenzymes results in increased metabolism of saikogenin A analog inhibits the reaction ABCB11 protein results in increased transport of Taurodeoxycholic Acid			[68]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	NADP co-treated with Uridine Diphosphate Glucuronic Acid co-treated with Phosphoadenosine Phosphosulfate promotes the reaction Enzymes and Coenzymes results in increased metabolism of saikogenin A inhibits the reaction ABCB11 protein results in increased transport of Taurodeoxycholic Acid			[68]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	NADP promotes the reaction Enzymes and Coenzymes results in increased metabolism of saikogenin A analog inhibits the reaction ABCB11 protein results in increased transport of Taurodeoxycholic Acid			[68]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	NADP promotes the reaction Enzymes and Coenzymes results in increased metabolism of saikogenin A inhibits the reaction ABCB11 protein results in increased transport of Taurodeoxycholic Acid			[68]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	saikogenin A analog inhibits the reaction ABCB11 protein results in increased transport of Taurodeoxycholic Acid			[68]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	saikogenin A inhibits the reaction ABCB11 protein results in increased transport of Taurodeoxycholic Acid			[68]
Regulation Mechanism				Transcription Factor Info
saikogenin F	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	saikogenin F inhibits the reaction ABCB11 protein results in increased transport of Taurodeoxycholic Acid			[68]
Regulation Mechanism				Transcription Factor Info
saikosaponin D	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Enzymes and Coenzymes inhibits the reaction saikosaponin D analog inhibits the reaction ABCB11 protein results in increased transport of Taurodeoxycholic Acid			[68]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Enzymes and Coenzymes inhibits the reaction saikosaponin D inhibits the reaction ABCB11 protein results in increased transport of Taurodeoxycholic Acid			[68]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	saikosaponin D analog inhibits the reaction ABCB11 protein results in increased transport of Taurodeoxycholic Acid			[68]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	saikosaponin D inhibits the reaction ABCB11 protein results in increased transport of Taurodeoxycholic Acid			[68]
Regulation Mechanism				Transcription Factor Info
senecionine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	senecionine results in decreased expression of ABCB11 mRNA			[49]
Regulation Mechanism				Transcription Factor Info
senkirkine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	senkirkine results in decreased expression of ABCB11 mRNA			[49]
Regulation Mechanism				Transcription Factor Info
Silymarin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Silymarin inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Silymarin results in decreased activity of ABCB11 protein			[26]
Regulation Mechanism				Transcription Factor Info
simvastatin acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	simvastatin acid inhibits the reaction ABCB11 protein affects the import of Taurocholic Acid			[9]
Regulation Mechanism				Transcription Factor Info
sitaxsentan	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	sitaxsentan results in decreased activity of ABCB11 protein			[25]
Regulation Mechanism				Transcription Factor Info
sodium arsenite	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	sodium arsenite results in decreased expression of ABCB11 mRNA			[55]
Regulation Mechanism				Transcription Factor Info
Sodium Selenite	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sodium Selenite results in decreased expression of ABCB11 mRNA			[107]
Regulation Mechanism				Transcription Factor Info
Staurosporine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Staurosporine results in decreased activity of ABCB11 protein			[21]
Regulation Mechanism				Transcription Factor Info
Sulfamethoxazole	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sulfamethoxazole inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Sulfamethoxazole results in decreased activity of ABCB11 protein			[26]
Regulation Mechanism				Transcription Factor Info
tanshinone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	tanshinone inhibits the reaction ABCB11 protein results in increased transport of Taurodeoxycholic Acid			[68]
Regulation Mechanism				Transcription Factor Info
tasosartan	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	tasosartan results in decreased activity of ABCB11 protein			[29]
Regulation Mechanism				Transcription Factor Info
Taurocholic Acid	100 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	2-methoxy-N-(3-(4-((3-methyl-4-((6-methyl-3-pyridinyl)oxy)phenyl)amino)-6-quinazolinyl)-2-propenyl)acetamide inhibits the reaction ABCB11 protein results in increased import of Taurocholic Acid			[64]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	ABCB11 protein affects the import of Taurocholic Acid			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	ABCB11 protein affects the transport of Taurocholic Acid			[95]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	ABCB11 protein results in increased export of Taurocholic Acid			[94]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	ABCB11 protein results in increased import of Taurocholic Acid			[64]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	ABCB11 protein results in increased uptake of Taurocholic Acid			[96]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	Amiodarone inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation10	Astemizole inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation11	Atazanavir Sulfate inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation12	Atenolol inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation13	Atorvastatin inhibits the reaction ABCB11 protein affects the import of Taurocholic Acid			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation14	Atorvastatin inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation15	Atropine inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation16	Benzbromarone inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation17	bisbenzimide ethoxide trihydrochloride inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation18	Bosentan inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation19	Budesonide inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation20	Calcium deficiency inhibits the reaction ABCB11 protein results in increased export of Taurocholic Acid			[78]
Regulation Mechanism				Transcription Factor Info
DT Modulation21	Cefaclor inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation22	Celecoxib inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation23	cerivastatin inhibits the reaction ABCB11 protein affects the import of Taurocholic Acid			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation24	cerivastatin inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation25	chelerythrine inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation26	Cholates inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation27	Cholic Acid inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation28	Clarithromycin inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation29	Clotrimazole inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation30	Cyclosporine inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation31	Dehydroepiandrosterone Sulfate inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation32	Diclofenac inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation33	Diethylstilbestrol inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation34	Dipyridamole inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation35	Disulfiram inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation36	efavirenz inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation37	Elacridar inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation38	ergocristine inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation39	Erythromycin inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation40	Ezetimibe inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation41	Felodipine inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation42	Fenofibrate inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation43	Floxacillin inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation44	Fluvastatin inhibits the reaction ABCB11 protein affects the import of Taurocholic Acid			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation45	Fluvoxamine inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation46	Fusidic Acid inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation47	glimepiride inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation48	Glipizide inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation49	Glyburide inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation50	Glycyrrhizic Acid inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation51	Imatinib Mesylate inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation52	Indinavir inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation53	Indocyanine Green inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation54	Indomethacin inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation55	Isradipine inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation56	Ketoconazole inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation57	Kynurenic Acid inhibits the reaction ABCB11 protein results in increased uptake of Taurocholic Acid			[96]
Regulation Mechanism				Transcription Factor Info
DT Modulation58	Lopinavir inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation59	Loratadine inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation60	Losartan inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation61	Lovastatin inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation62	Midazolam inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation63	Mifepristone inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation64	morin inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation65	Naproxen inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation66	nefazodone inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation67	Nelfinavir inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation68	Nicardipine inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation69	Nifedipine inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation70	Nitrendipine inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation71	Nitrofurantoin inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation72	Ofloxacin inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation73	olmesartan inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation74	pilsicainide inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation75	pitavastatin inhibits the reaction ABCB11 protein affects the import of Taurocholic Acid			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation76	pitavastatin inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation77	Pravastatin inhibits the reaction ABCB11 protein affects the import of Taurocholic Acid			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation78	Progesterone inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation79	Ranolazine inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation80	repaglinide inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation81	Reserpine inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation82	Rifampin inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation83	Ritonavir inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation84	Rosiglitazone inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation85	Rosuvastatin Calcium inhibits the reaction ABCB11 protein affects the import of Taurocholic Acid			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation86	Saquinavir inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation87	Silymarin inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation88	simvastatin acid inhibits the reaction ABCB11 protein affects the import of Taurocholic Acid			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation89	Simvastatin inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation90	Spironolactone inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation91	Sulfamethoxazole inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation92	Sulfinpyrazone inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation93	Taurolithocholic Acid inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation94	Telmisartan inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation95	Terfenadine inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation96	Tinidazole inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation97	tipranavir inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation98	Troglitazone inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation99	verlukast inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation100	Vinblastine inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
Taurodeoxycholic Acid	42 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCB11 protein results in increased transport of Taurodeoxycholic Acid			[68]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Aconitine inhibits the reaction ABCB11 protein results in increased transport of Taurodeoxycholic Acid			[68]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	aurantio-obtusin inhibits the reaction ABCB11 protein results in increased transport of Taurodeoxycholic Acid			[68]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	carboxyatractyloside inhibits the reaction ABCB11 protein results in increased transport of Taurodeoxycholic Acid			[68]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	celastrol inhibits the reaction ABCB11 protein results in increased transport of Taurodeoxycholic Acid			[68]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	cryptotanshinone inhibits the reaction ABCB11 protein results in increased transport of Taurodeoxycholic Acid			[68]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	Cyclosporine inhibits the reaction ABCB11 protein results in increased transport of Taurodeoxycholic Acid			[68]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	dihydrotanshinone I inhibits the reaction ABCB11 protein results in increased transport of Taurodeoxycholic Acid			[68]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	diosbulbin B metabolite inhibits the reaction ABCB11 protein results in increased transport of Taurodeoxycholic Acid			[68]
Regulation Mechanism				Transcription Factor Info
DT Modulation10	diosbulbin B promotes the reaction ABCB11 protein results in increased transport of Taurodeoxycholic Acid			[68]
Regulation Mechanism				Transcription Factor Info
DT Modulation11	Enzymes and Coenzymes inhibits the reaction celastrol inhibits the reaction ABCB11 protein results in increased transport of Taurodeoxycholic Acid			[68]
Regulation Mechanism				Transcription Factor Info
DT Modulation12	Enzymes and Coenzymes inhibits the reaction diosbulbin B promotes the reaction ABCB11 protein results in increased transport of Taurodeoxycholic Acid			[68]
Regulation Mechanism				Transcription Factor Info
DT Modulation13	Enzymes and Coenzymes inhibits the reaction isobavachalcone inhibits the reaction ABCB11 protein results in increased transport of Taurodeoxycholic Acid			[68]
Regulation Mechanism				Transcription Factor Info
DT Modulation14	Enzymes and Coenzymes inhibits the reaction rhein promotes the reaction ABCB11 protein results in increased transport of Taurodeoxycholic Acid			[68]
Regulation Mechanism				Transcription Factor Info
DT Modulation15	Enzymes and Coenzymes inhibits the reaction saikosaponin D analog inhibits the reaction ABCB11 protein results in increased transport of Taurodeoxycholic Acid			[68]
Regulation Mechanism				Transcription Factor Info
DT Modulation16	Enzymes and Coenzymes inhibits the reaction saikosaponin D inhibits the reaction ABCB11 protein results in increased transport of Taurodeoxycholic Acid			[68]
Regulation Mechanism				Transcription Factor Info
DT Modulation17	Enzymes and Coenzymes promotes the reaction saikogenin A analog inhibits the reaction ABCB11 protein results in increased transport of Taurodeoxycholic Acid			[68]
Regulation Mechanism				Transcription Factor Info
DT Modulation18	Enzymes and Coenzymes promotes the reaction saikogenin A inhibits the reaction ABCB11 protein results in increased transport of Taurodeoxycholic Acid			[68]
Regulation Mechanism				Transcription Factor Info
DT Modulation19	Enzymes and Coenzymes promotes the reaction Troglitazone inhibits the reaction ABCB11 protein results in increased transport of Taurodeoxycholic Acid			[68]
Regulation Mechanism				Transcription Factor Info
DT Modulation20	Glyburide results in decreased activity of ABCB11 protein which results in decreased export of Taurodeoxycholic Acid			[94]
Regulation Mechanism				Transcription Factor Info
DT Modulation21	isobavachalcone inhibits the reaction ABCB11 protein results in increased transport of Taurodeoxycholic Acid			[68]
Regulation Mechanism				Transcription Factor Info
DT Modulation22	kansuinin A inhibits the reaction ABCB11 protein results in increased transport of Taurodeoxycholic Acid			[68]
Regulation Mechanism				Transcription Factor Info
DT Modulation23	kansuinin B inhibits the reaction ABCB11 protein results in increased transport of Taurodeoxycholic Acid			[68]
Regulation Mechanism				Transcription Factor Info
DT Modulation24	Ketoconazole results in decreased activity of ABCB11 protein which results in decreased export of Taurodeoxycholic Acid			[94]
Regulation Mechanism				Transcription Factor Info
DT Modulation25	mesaconitine inhibits the reaction ABCB11 protein results in increased transport of Taurodeoxycholic Acid			[68]
Regulation Mechanism				Transcription Factor Info
DT Modulation26	NADP co-treated with Uridine Diphosphate Glucuronic Acid co-treated with Phosphoadenosine Phosphosulfate promotes the reaction Enzymes and Coenzymes results in increased metabolism of diosbulbin B inhibits the reaction ABCB11 protein results in increased transport of Taurodeoxycholic Acid			[68]
Regulation Mechanism				Transcription Factor Info
DT Modulation27	NADP co-treated with Uridine Diphosphate Glucuronic Acid co-treated with Phosphoadenosine Phosphosulfate promotes the reaction Enzymes and Coenzymes results in increased metabolism of saikogenin A analog inhibits the reaction ABCB11 protein results in increased transport of Taurodeoxycholic Acid			[68]
Regulation Mechanism				Transcription Factor Info
DT Modulation28	NADP co-treated with Uridine Diphosphate Glucuronic Acid co-treated with Phosphoadenosine Phosphosulfate promotes the reaction Enzymes and Coenzymes results in increased metabolism of saikogenin A inhibits the reaction ABCB11 protein results in increased transport of Taurodeoxycholic Acid			[68]
Regulation Mechanism				Transcription Factor Info
DT Modulation29	NADP promotes the reaction Enzymes and Coenzymes results in increased metabolism of diosbulbin B inhibits the reaction ABCB11 protein results in increased transport of Taurodeoxycholic Acid			[68]
Regulation Mechanism				Transcription Factor Info
DT Modulation30	NADP promotes the reaction Enzymes and Coenzymes results in increased metabolism of saikogenin A analog inhibits the reaction ABCB11 protein results in increased transport of Taurodeoxycholic Acid			[68]
Regulation Mechanism				Transcription Factor Info
DT Modulation31	NADP promotes the reaction Enzymes and Coenzymes results in increased metabolism of saikogenin A inhibits the reaction ABCB11 protein results in increased transport of Taurodeoxycholic Acid			[68]
Regulation Mechanism				Transcription Factor Info
DT Modulation32	rhein metabolite inhibits the reaction ABCB11 protein results in increased transport of Taurodeoxycholic Acid			[68]
Regulation Mechanism				Transcription Factor Info
DT Modulation33	rhein promotes the reaction ABCB11 protein results in increased transport of Taurodeoxycholic Acid			[68]
Regulation Mechanism				Transcription Factor Info
DT Modulation34	saikogenin A analog inhibits the reaction ABCB11 protein results in increased transport of Taurodeoxycholic Acid			[68]
Regulation Mechanism				Transcription Factor Info
DT Modulation35	saikogenin A inhibits the reaction ABCB11 protein results in increased transport of Taurodeoxycholic Acid			[68]
Regulation Mechanism				Transcription Factor Info
DT Modulation36	saikogenin F inhibits the reaction ABCB11 protein results in increased transport of Taurodeoxycholic Acid			[68]
Regulation Mechanism				Transcription Factor Info
DT Modulation37	saikosaponin D analog inhibits the reaction ABCB11 protein results in increased transport of Taurodeoxycholic Acid			[68]
Regulation Mechanism				Transcription Factor Info
DT Modulation38	saikosaponin D inhibits the reaction ABCB11 protein results in increased transport of Taurodeoxycholic Acid			[68]
Regulation Mechanism				Transcription Factor Info
DT Modulation39	tanshinone inhibits the reaction ABCB11 protein results in increased transport of Taurodeoxycholic Acid			[68]
Regulation Mechanism				Transcription Factor Info
DT Modulation40	toosendanin inhibits the reaction ABCB11 protein results in increased transport of Taurodeoxycholic Acid			[68]
Regulation Mechanism				Transcription Factor Info
DT Modulation41	Troglitazone inhibits the reaction ABCB11 protein results in increased transport of Taurodeoxycholic Acid			[68]
Regulation Mechanism				Transcription Factor Info
DT Modulation42	Troglitazone results in decreased activity of ABCB11 protein which results in decreased export of Taurodeoxycholic Acid			[94]
Regulation Mechanism				Transcription Factor Info
Taurolithocholic Acid	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Taurolithocholic Acid inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Taurolithocholic Acid results in decreased activity of ABCB11 protein			[26]
Regulation Mechanism				Transcription Factor Info
telithromycin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	telithromycin results in decreased activity of ABCB11 protein			[21]
Regulation Mechanism				Transcription Factor Info
temsirolimus	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	temsirolimus results in decreased activity of ABCB11 protein			[25]
Regulation Mechanism				Transcription Factor Info
tert-Butylhydroperoxide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	tert-Butylhydroperoxide results in decreased expression of ABCB11 mRNA			[32]
Regulation Mechanism				Transcription Factor Info
Tetrachlorodibenzodioxin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tetrachlorodibenzodioxin results in decreased expression of ABCB11 mRNA			[19]
Regulation Mechanism				Transcription Factor Info
Theophylline	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Theophylline results in decreased activity of ABCB11 protein			[66]
Regulation Mechanism				Transcription Factor Info
tipranavir	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	tipranavir inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	tipranavir results in decreased activity of ABCB11 protein			[26]
Regulation Mechanism				Transcription Factor Info
toosendanin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	toosendanin inhibits the reaction ABCB11 protein results in increased transport of Taurodeoxycholic Acid			[68]
Regulation Mechanism				Transcription Factor Info
Triclosan	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Triclosan results in increased expression of ABCB11 mRNA			[67]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Triclosan results in decreased expression of ABCB11 mRNA			[110]
Regulation Mechanism				Transcription Factor Info
Triiodothyronine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Triiodothyronine results in decreased activity of ABCB11 protein			[29]
Regulation Mechanism				Transcription Factor Info
triptolide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	triptolide results in decreased expression of ABCB11 protein			[111]
Regulation Mechanism				Transcription Factor Info
Uridine Diphosphate Glucuronic Acid	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	NADP co-treated with Uridine Diphosphate Glucuronic Acid co-treated with Phosphoadenosine Phosphosulfate promotes the reaction Enzymes and Coenzymes results in increased metabolism of diosbulbin B inhibits the reaction ABCB11 protein results in increased transport of Taurodeoxycholic Acid			[68]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	NADP co-treated with Uridine Diphosphate Glucuronic Acid co-treated with Phosphoadenosine Phosphosulfate promotes the reaction Enzymes and Coenzymes results in increased metabolism of saikogenin A analog inhibits the reaction ABCB11 protein results in increased transport of Taurodeoxycholic Acid			[68]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	NADP co-treated with Uridine Diphosphate Glucuronic Acid co-treated with Phosphoadenosine Phosphosulfate promotes the reaction Enzymes and Coenzymes results in increased metabolism of saikogenin A inhibits the reaction ABCB11 protein results in increased transport of Taurodeoxycholic Acid			[68]
Regulation Mechanism				Transcription Factor Info
valrubicin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	valrubicin results in decreased activity of ABCB11 protein			[25]
Regulation Mechanism				Transcription Factor Info
verlukast	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	verlukast inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	verlukast results in decreased activity of ABCB11 protein			[21]
Regulation Mechanism				Transcription Factor Info
Vitamin K 3	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Vitamin K 3 results in decreased expression of ABCB11 mRNA			[32]
Regulation Mechanism				Transcription Factor Info
Wortmannin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Wortmannin results in decreased activity of ABCB11 protein			[21]
Regulation Mechanism				Transcription Factor Info
zafirlukast	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	zafirlukast results in decreased activity of ABCB11 protein			[25]
Regulation Mechanism				Transcription Factor Info
Zinc Sulfate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Zinc Sulfate inhibits the reaction Copper Sulfate inhibits the reaction Chenodeoxycholic Acid results in increased expression of ABCB11 mRNA			[85]
Regulation Mechanism				Transcription Factor Info
Dietary Constituent
Calcium	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Calcium deficiency inhibits the reaction ABCB11 protein results in increased export of Taurocholic Acid			[78]
Regulation Mechanism				Transcription Factor Info
Nanoparticle
perfluoro-n-nonanoic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	perfluoro-n-nonanoic acid results in decreased expression of ABCB11 mRNA			[101]
Regulation Mechanism				Transcription Factor Info
Fungicide
tebuconazole	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	tebuconazole promotes the reaction propiconazole results in decreased expression of ABCB11 mRNA			[106]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	tebuconazole results in decreased activity of ABCB11 protein			[106]
Regulation Mechanism				Transcription Factor Info
Approved Drug
Cyclosporine	13 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cyclosporine inhibits the transportation of Glycocholate by ABCB11 (IC50 = 0.93 microM)			[1]
Affected Drug/Substrate	Glycocholate	Modulation Type	Inhibition
Cell System	Spodoptera frugiperda (Sf9) cells-BSEP
DT Modulation2	Cyclosporine inhibits the transportation of Sodium taurocholate by ABCB11 (IC50 = 18.9 microM)			[1]
Affected Drug/Substrate	Sodium taurocholate	Modulation Type	Inhibition
Cell System	Spodoptera frugiperda (Sf9) cells-BSEP
DT Modulation3	Cyclosporine inhibits the transportation of Sodium taurocholate by ABCB11 (IC50 = 8.4 microM)			[1]
Affected Drug/Substrate	Sodium taurocholate	Modulation Type	Inhibition
Cell System	Spodoptera frugiperda (Sf9) cells-BSEP
DT Modulation4	Cyclosporine inhibits the transportation of Taurochenodeoxycholate by ABCB11 (IC50 = 0.94 microM)			[1]
Affected Drug/Substrate	Taurochenodeoxycholate	Modulation Type	Inhibition
Cell System	Spodoptera frugiperda (Sf9) cells-BSEP
DT Modulation5	Cyclosporine inhibits the transportation of Taurochenodeoxycholate by ABCB11 (Ki = 9.5 microM)			[2]
Affected Drug/Substrate	Taurochenodeoxycholate	Modulation Type	Inhibition
Cell System	High Five cells-BSEP
DT Modulation6	Cyclosporine inhibits the transportation of Bodipy by ABCB11 (IC50 = 7.5 microM)			[3]
Affected Drug/Substrate	Bodipy	Modulation Type	Inhibition
DT Modulation7	Cyclosporine inhibits the transportation of Dihydrofluorescein by ABCB11 (IC50 = 7.8 microM)			[3]
Affected Drug/Substrate	Dihydrofluorescein	Modulation Type	Inhibition
DT Modulation8	Cyclosporine inhibits the transportation of Sodium taurocholate by ABCB11			[4]
Affected Drug/Substrate	Sodium taurocholate	Modulation Type	Inhibition
Cell System	Hepatocyte-BSEP
DT Modulation9	Cyclosporine inhibits the activity of ABCB11			[5]
Glyburide	11 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Glibenclamide inhibits the transportation of Glycocholate by ABCB11 (IC50 = 18.8 microM)			[1]
Affected Drug/Substrate	Glycocholate	Modulation Type	Inhibition
Cell System	Spodoptera frugiperda (Sf9) cells-BSEP
DT Modulation2	Glibenclamide inhibits the transportation of Sodium taurocholate by ABCB11 (IC50 = 14.7 microM)			[1]
Affected Drug/Substrate	Sodium taurocholate	Modulation Type	Inhibition
Cell System	Spodoptera frugiperda (Sf9) cells-BSEP
DT Modulation3	Glibenclamide inhibits the transportation of Sodium taurocholate by ABCB11 (IC50 = 11.3 microM)			[1]
Affected Drug/Substrate	Sodium taurocholate	Modulation Type	Inhibition
Cell System	Spodoptera frugiperda (Sf9) cells-BSEP
DT Modulation4	Glibenclamide inhibits the transportation of Sodium taurocholate by ABCB11 (Ki = 27.5 microM)			[2]
Affected Drug/Substrate	Sodium taurocholate	Modulation Type	Inhibition
Cell System	High Five cells-BSEP
DT Modulation5	Glibenclamide inhibits the transportation of Taurochenodeoxycholate by ABCB11 (IC50 = 15.8 microM)			[1]
Affected Drug/Substrate	Taurochenodeoxycholate	Modulation Type	Inhibition
Cell System	Spodoptera frugiperda (Sf9) cells-BSEP
DT Modulation6	Glibenclamide inhibits the transportation of Bodipy by ABCB11 (IC50 = 260.1 microM)			[3]
Affected Drug/Substrate	Bodipy	Modulation Type	Inhibition
DT Modulation7	Glibenclamide inhibits the transportation of Dihydrofluorescein by ABCB11 (IC50 = 146.5 microM)			[3]
Affected Drug/Substrate	Dihydrofluorescein	Modulation Type	Inhibition
DT Modulation8	Glibenclamide inhibits the activity of ABCB11			[6], [7]
Troglitazone	10 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Troglitazone inhibits the transportation of Glycocholate by ABCB11 (IC50 = 16 microM)			[1]
Affected Drug/Substrate	Glycocholate	Modulation Type	Inhibition
Cell System	Spodoptera frugiperda (Sf9) cells-BSEP
DT Modulation2	Troglitazone inhibits the transportation of Sodium taurocholate by ABCB11 (IC50 = 9.5 microM)			[1]
Affected Drug/Substrate	Sodium taurocholate	Modulation Type	Inhibition
Cell System	Spodoptera frugiperda (Sf9) cells-BSEP
DT Modulation3	Troglitazone inhibits the transportation of Taurochenodeoxycholate by ABCB11 (IC50 = 27.6 microM)			[1]
Affected Drug/Substrate	Taurochenodeoxycholate	Modulation Type	Inhibition
Cell System	Spodoptera frugiperda (Sf9) cells-BSEP
DT Modulation4	Troglitazone induces the activity of ABCB11			[8]
Progesterone	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Progesterone inhibits the transportation of Bodipy by ABCB11 (IC50 = 224.6 microM)			[3]
Affected Drug/Substrate	Bodipy	Modulation Type	Inhibition
DT Modulation2	Progesterone inhibits the transportation of Dihydrofluorescein by ABCB11 (IC50 = 17.3 microM)			[3]
Affected Drug/Substrate	Dihydrofluorescein	Modulation Type	Inhibition
Atorvastatin	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Atorvastatin inhibits the transportation of Sodium taurocholate by ABCB11 (Ki = 9.12 microM)			[9]
Affected Drug/Substrate	Sodium taurocholate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-BSEP
DT Modulation2	Atorvastatin inhibits the reaction ABCB11 protein affects the import of Taurocholic Acid			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Atorvastatin inhibits the reaction ABCB11 protein results in increased transport of Taurocholic Acid			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Atorvastatin results in decreased activity of ABCB11 protein			[25]
Regulation Mechanism				Transcription Factor Info
Cerivastatin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cerivastatin inhibits the transportation of Sodium taurocholate by ABCB11 (Ki = 11.4 microM)			[9]
Affected Drug/Substrate	Sodium taurocholate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-BSEP
Clofazimine	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Clofazimine inhibits the transportation of Sodium taurocholate by ABCB11 (IC50 = 2.3 microM)			[1]
Affected Drug/Substrate	Sodium taurocholate	Modulation Type	Inhibition
Cell System	Spodoptera frugiperda (Sf9) cells-BSEP
Reserpine	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Reserpine inhibits the transportation of Sodium taurocholate by ABCB11 (IC50 = 2.8 microM)			[1]
Affected Drug/Substrate	Sodium taurocholate	Modulation Type	Inhibition
Cell System	Spodoptera frugiperda (Sf9) cells-BSEP
Rifampicin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Rifampicin inhibits the transportation of Sodium taurocholate by ABCB11 (IC50 = 10.5 microM)			[1]
Affected Drug/Substrate	Sodium taurocholate	Modulation Type	Inhibition
Cell System	Spodoptera frugiperda (Sf9) cells-BSEP
Candesartan cilexetil	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Candesartan cilexetil inhibits the activity of ABCB11 (IC50 = 6.2 microM)			[11]
Cell System	Human hepatocytes-BSEP
Chenodeoxycholic acid	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Chenodiol induces the activity of ABCB11			[12]
Cell System	Hepatocyte-BSEP
DT Modulation2	Chenodeoxycholic acid induces the activity of ABCB11			[36], [37]
Rifampin	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Rifampin inhibits the expression of ABCB11			[14]
Regulation Mechanism	via enhancement of Nuclear receptor subfamily 1 group I member 2 (NR1I2)			Transcription Factor Info
Cell System	Human hepatocytes (HH1089)
Ursodeoxycholic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ursodeoxycholic Acid increases the expression of ABCB11			[15]
Regulation Mechanism	via enhancement of Bile acid receptor (NR1H4)			Transcription Factor Info
Cell System	C57/BL6 mice
Deoxycholic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Deoxycholic acid increases the expression of ABCB11			[16]
Regulation Mechanism	via enhancement of Bile acid receptor (NR1H4)			Transcription Factor Info
Cell System	New zealand white rabbits
Obeticholic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Obeticholic acid increases the expression of ABCB11			[17]
Regulation Mechanism	via enhancement of Bile acid receptor (NR1H4)			Transcription Factor Info
Cell System	C57BL6/J mice
Tamoxifen	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tamoxifen inhibits the activity of ABCB11			[3]
Phenobarbital	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Phenobarbital inhibits the expression of ABCB11			[19]
Methimazole	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Methimazole increases the expression of ABCB11			[20]
Amprenavir	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Amprenavir inhibits the activity of ABCB11			[21]
Clofibrate	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Clofibrate inhibits the activity of ABCB11			[21]
Dicloxacillin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Dicloxacillin inhibits the activity of ABCB11			[21]
Finasteride	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Finasteride inhibits the activity of ABCB11			[21]
Mibefradil	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Mibefradil inhibits the activity of ABCB11			[21]
Omeprazole	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Omeprazole inhibits the activity of ABCB11			[21]
Primaquine	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Primaquine inhibits the activity of ABCB11			[21]
Sorafenib	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sorafenib inhibits the activity of ABCB11			[21]
Tolcapone	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tolcapone inhibits the activity of ABCB11			[21]
Dexamethasone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Dexamethasone increases the expression of ABCB11			[22]
Acetaminophen	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Acetaminophen inhibits the expression of ABCB11			[23]
DT Modulation2	Acetaminophen results in decreased activity of ABCB11 protein			[66]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Acetaminophen results in increased expression of ABCB11 protein			[62]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Acetaminophen results in decreased expression of ABCB11 mRNA			[67]
Regulation Mechanism				Transcription Factor Info
Bromfenac	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Bromfenac inhibits the activity of ABCB11			[24]
Clozapine	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Clozapine inhibits the activity of ABCB11			[24]
Olanzapine	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Olanzapine inhibits the activity of ABCB11			[24]
Ticlopidine	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ticlopidine inhibits the activity of ABCB11			[24]
Cisapride	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cisapride inhibits the activity of ABCB11			[25]
Danazol	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Danazol inhibits the activity of ABCB11			[25]
Dasatinib	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Dasatinib inhibits the activity of ABCB11			[25]
Drospirenone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Drospirenone inhibits the activity of ABCB11			[25]
Everolimus	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Everolimus inhibits the activity of ABCB11			[25]
Iloperidone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Iloperidone inhibits the activity of ABCB11			[25]
Irbesartan	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Irbesartan inhibits the activity of ABCB11			[25]
Medroxyprogesterone Acetate	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Medroxyprogesterone Acetate inhibits the activity of ABCB11			[25]
Megestrol Acetate	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Megestrol Acetate inhibits the activity of ABCB11			[25]
Neratinib	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Neratinib inhibits the activity of ABCB11			[25]
Olmesartan medoxomil	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Olmesartan medoxomil inhibits the activity of ABCB11			[25]
pimecrolimus	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	pimecrolimus inhibits the activity of ABCB11			[25]
Posaconazole	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Posaconazole inhibits the activity of ABCB11			[25]
Rifapentine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Rifapentine inhibits the activity of ABCB11			[25]
Tacrolimus	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tacrolimus inhibits the activity of ABCB11			[25]
Temsirolimus	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Temsirolimus inhibits the activity of ABCB11			[25]
Atropine	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Atropine inhibits the activity of ABCB11			[26]
Cefaclor	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cefaclor inhibits the activity of ABCB11			[26]
Cholic Acid	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cholic Acid inhibits the activity of ABCB11			[26]
Clarithromycin	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Clarithromycin inhibits the activity of ABCB11			[26]
Clotrimazole	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Clotrimazole inhibits the activity of ABCB11			[26]
Diethylstilbestrol	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Diethylstilbestrol inhibits the activity of ABCB11			[26]
Efavirenz	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Efavirenz inhibits the activity of ABCB11			[26]
Erythromycin	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Erythromycin inhibits the activity of ABCB11			[26]
Ezetimibe	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ezetimibe inhibits the activity of ABCB11			[26]
Felodipine	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Felodipine inhibits the activity of ABCB11			[26]
Fluvoxamine	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Fluvoxamine inhibits the activity of ABCB11			[26]
Glipizide	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Glipizide inhibits the activity of ABCB11			[26]
Indocyanine green	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Indocyanine green inhibits the activity of ABCB11			[26]
Isradipine	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Isradipine inhibits the activity of ABCB11			[26]
Naproxen	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Naproxen inhibits the activity of ABCB11			[26]
Nifedipine	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Nifedipine inhibits the activity of ABCB11			[26]
Nitrofurantoin	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Nitrofurantoin inhibits the activity of ABCB11			[26]
Ofloxacin	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ofloxacin inhibits the activity of ABCB11			[26]
Pitavastatin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Pitavastatin inhibits the activity of ABCB11			[26]
Ranolazine	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ranolazine inhibits the activity of ABCB11			[26]
Spironolactone	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Spironolactone inhibits the activity of ABCB11			[26]
Sulfinpyrazone	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sulfinpyrazone inhibits the activity of ABCB11			[26]
Tinidazole	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tinidazole inhibits the activity of ABCB11			[26]
Vinblastine	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Vinblastine inhibits the activity of ABCB11			[26]
Tolvaptan	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tolvaptan inhibits the activity of ABCB11			[27]
Ethinyl Estradiol	5 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ethinyl Estradiol inhibits the expression of ABCB11			[28]
Bicalutamide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Bicalutamide inhibits the activity of ABCB11			[29]
Dihydroergotamine	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Dihydroergotamine inhibits the activity of ABCB11			[29]
Liothyronine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Liothyronine inhibits the activity of ABCB11			[29]
Primidone	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Primidone inhibits the activity of ABCB11			[29]
Valproic Acid	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Valproic Acid inhibits the expression of ABCB11			[30]
Tretinoin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tretinoin increases the expression of ABCB11			[31]
Menadione	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Menadione inhibits the expression of ABCB11			[32]
Nefazodone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Nefazodone inhibits the activity of ABCB11			[29]
Pioglitazone	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Pioglitazone inhibits the activity of ABCB11			[25]
Rosiglitazone	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Rosiglitazone inhibits the activity of ABCB11			[26]
Ritonavir	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ritonavir inhibits the activity of ABCB11			[29]
Indomethacin	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Indomethacin inhibits the activity of ABCB11			[26]
Gefitinib	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Gefitinib inhibits the activity of ABCB11			[25]
Paclitaxel	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Paclitaxel inhibits the activity of ABCB11			[25]
Fenofibrate	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Fenofibrate inhibits the activity of ABCB11			[26]
Glimepiride	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Glimepiride inhibits the activity of ABCB11			[26]
Lopinavir	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Lopinavir inhibits the activity of ABCB11			[26]
Nelfinavir	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Nelfinavir inhibits the activity of ABCB11			[26]
Nicardipine	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Nicardipine inhibits the activity of ABCB11			[26]
Saquinavir	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Saquinavir inhibits the activity of ABCB11			[26]
Simvastatin	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Simvastatin inhibits the activity of ABCB11			[26]
Telmisartan	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Telmisartan inhibits the activity of ABCB11			[26]
Indinavir	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Indinavir inhibits the activity of ABCB11			[29]
Lapatinib	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Lapatinib inhibits the activity of ABCB11			[29]
Pazopanib	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Pazopanib inhibits the activity of ABCB11			[29]
Amiodarone	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Amiodarone inhibits the activity of ABCB11			[26]
Imatinib Mesylate	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Imatinib Mesylate inhibits the activity of ABCB11			[26]
Midazolam	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Midazolam inhibits the activity of ABCB11			[26]
Celecoxib	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Celecoxib inhibits the activity of ABCB11			[26]
Dipyridamole	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Dipyridamole inhibits the activity of ABCB11			[26]
Losartan	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Losartan inhibits the activity of ABCB11			[26]
Lovastatin	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Lovastatin inhibits the activity of ABCB11			[26]
Mifepristone	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Mifepristone inhibits the activity of ABCB11			[26]
Repaglinide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Repaglinide inhibits the activity of ABCB11			[26]
Loratadine	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Loratadine inhibits the activity of ABCB11			[29]
Zafirlukast	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Zafirlukast inhibits the activity of ABCB11			[29]
Diclofenac	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Diclofenac inhibits the activity of ABCB11			[29]
Tipranavir	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tipranavir inhibits the activity of ABCB11			[29]
Atenolol	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Atenolol inhibits the activity of ABCB11			[26]
Budesonide	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Budesonide inhibits the activity of ABCB11			[26]
Disulfiram	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Disulfiram inhibits the activity of ABCB11			[26]
Conjugated estrogens	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Conjugated estrogens inhibits the activity of ABCB11			[33]
Fluvastatin	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Fluvastatin inhibits the activity of ABCB11			[33]
Pravastatin	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Pravastatin inhibits the activity of ABCB11			[34]
Bosentan	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Bosentan inhibits the activity of ABCB11			[35]
Cloxacillin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cloxacillin inhibits the activity of ABCB11			[38]
Midecamycin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Midecamycin inhibits the activity of ABCB11			[38]
Colchicine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Colchicine induces the activity of ABCB11			[39]
Rifamycin SV	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Rifamycin SV inhibits the activity of ABCB11			[40]
Micafungin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Micafungin inhibits the activity of ABCB11			[41]
Itraconazole	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Itraconazole inhibits the activity of ABCB11			[42]
Ketoconazole	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ketoconazole inhibits the activity of ABCB11			[42]
Drug Marketed but not Approved by US FDA
Bezafibrate	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Bezafibrate inhibits the expression of ABCB11			[18]
Etoricoxib	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Etoricoxib inhibits the activity of ABCB11			[21]
Gliquidone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Gliquidone inhibits the activity of ABCB11			[25]
Pranlukast	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Pranlukast inhibits the activity of ABCB11			[25]
Floxacillin	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Floxacillin inhibits the activity of ABCB11			[26]
Benzbromarone	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Benzbromarone inhibits the activity of ABCB11			[29]
Nitrendipine	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Nitrendipine inhibits the activity of ABCB11			[26]
Drug in Phase 3 Trial
Oltipraz	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Oltipraz increases the expression of ABCB11			[44]
Regulation Mechanism	via enhancement of Nuclear factor erythroid 2-related factor 2 (NFE2L2)			Transcription Factor Info
Cell System	Human hepatoblastoma cells (HepG2)
Epigallocatechin gallate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Epigallocatechin gallate increases the expression of ABCB11			[47]
Glycyrrhizic Acid	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Glycyrrhizic Acid inhibits the activity of ABCB11			[26]
Diethyltoluamide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Diethyltoluamide inhibits the expression of ABCB11			[50]
Vitamin E	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Vitamin E inhibits the expression of ABCB11			[32]
Fusidic Acid	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Fusidic Acid inhibits the activity of ABCB11			[26]
Drug in Phase 2 Trial
Ethanol	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ethanol inhibits the expression of ABCB11			[59]
Drug in Phase 1 Trial
Astemizole	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Astemizole inhibits the activity of ABCB11			[26]
Prasterone sulfate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Prasterone sulfate inhibits the activity of ABCB11			[26]
TAK-875	5 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	TAK-875 inhibits the activity of ABCB11			[53]
ANA-756	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ANA-756 inhibits the activity of ABCB11			[29]
Sodium arsenite	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sodium arsenite inhibits the expression of ABCB11			[55]
Quercetin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Quercetin inhibits the expression of ABCB11			[32]
Cinnarizine	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cinnarizine inhibits the activity of ABCB11			[25]
Drug in Preclinical Test
AM-2282	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	AM-2282 inhibits the activity of ABCB11			[25]
Investigative Drug
Valinomycin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Valinomycin inhibits the transportation of Sodium taurocholate by ABCB11 (IC50 = 0.7 microM)			[1]
Affected Drug/Substrate	Sodium taurocholate	Modulation Type	Inhibition
Cell System	Spodoptera frugiperda (Sf9) cells-BSEP
Epigalocatechin gallate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Epigalocatechin gallate inhibits the transportation of Bodipy by ABCB11 (IC50 = 214 microM)			[3]
Affected Drug/Substrate	Bodipy	Modulation Type	Inhibition
Lithocholic Acid	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Lithocholic Acid inhibits the expression of ABCB11			[43]
Regulation Mechanism	via the inhibition of Bile acid receptor (NR1H4)			Transcription Factor Info
Cell System	Human hepatoblastoma cells (HepG2)
Ciglitazone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ciglitazone inhibits the activity of ABCB11			[21]
Chelerythrine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Chelerythrine inhibits the activity of ABCB11			[26]
Taurolithocholate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Taurolithocholate inhibits the activity of ABCB11			[26]
Baohuoside I	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Baohuoside I inhibits the expression of ABCB11			[60]
Patented Pharmaceutical Agent
GW-4064	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	GW-4064 increases the expression of ABCB11			[43]
Regulation Mechanism	via enhancement of Bile acid receptor (NR1H4)			Transcription Factor Info
Cell System	Human hepatoblastoma cells (HepG2)
Drug Withdrawn
Sitaxsentan	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sitaxsentan inhibits the activity of ABCB11			[25]
Terfenadine	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Terfenadine inhibits the activity of ABCB11			[26]
Natural Product
Cyanidin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cyanidin inhibits the activity of ABCB11 (IC50 = 7.6 microM)			[10]
Cell System	Human breast adenocarcinoma cell line (MCF-7)-BSEP
Cyanidin-3,5-diglucoside	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cyanidin-3,5-diglucoside inhibits the activity of ABCB11 (IC50 = 43 microM)			[10]
Cell System	Human breast adenocarcinoma cell line (MCF-7)-BSEP
Delphinidin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Delphinidin inhibits the activity of ABCB11 (IC50 = 87 microM)			[10]
Cell System	Human breast adenocarcinoma cell line (MCF-7)-BSEP
Malvidin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Malvidin inhibits the activity of ABCB11 (IC50 = 49 microM)			[10]
Cell System	Human breast adenocarcinoma cell line (MCF-7)-BSEP
Pelargonidin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Pelargonidin inhibits the activity of ABCB11 (IC50 = 76 microM)			[10]
Cell System	Human breast adenocarcinoma cell line (MCF-7)-BSEP
Peonidin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Peonidin inhibits the activity of ABCB11 (IC50 = 30 microM)			[10]
Cell System	Human breast adenocarcinoma cell line (MCF-7)-BSEP
Petunidin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Petunidin inhibits the activity of ABCB11 (IC50 = 193 microM)			[10]
Cell System	Human breast adenocarcinoma cell line (MCF-7)-BSEP
Boldine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Boldine induces the activity of ABCB11			[13]
Cell System	Model organism in vivo (rat)
Guggulsterone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Guggulsterone inhibits the expression of ABCB11			[45]
Regulation Mechanism	via the inhibition of Bile acid receptor (NR1H4)			Transcription Factor Info
Cell System	Human primary hepatocytes
Epicatechin gallate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Epicatechin gallate increases the expression of ABCB11			[47]
Gallocatechol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Gallocatechol increases the expression of ABCB11			[47]
Particulate Matter	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Particulate Matter inhibits the expression of ABCB11			[48]
Heliotrine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Heliotrine inhibits the expression of ABCB11			[49]
Senecionine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Senecionine inhibits the expression of ABCB11			[49]
Tobacco Smoke Pollution	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tobacco Smoke Pollution inhibits the expression of ABCB11			[52]
Methyleugenol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Methyleugenol inhibits the expression of ABCB11			[58]
Environmental toxicant
Dichlorodiphenyl Dichloroethylene	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Dichlorodiphenyl Dichloroethylene increases the expression of ABCB11			[54]
Polychlorinated dibenzodioxin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Polychlorinated dibenzodioxin inhibits the expression of ABCB11			[52]
Mycotoxins
Aflatoxin B1	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Aflatoxin B1 inhibits the expression of ABCB11			[46]
DT Modulation2	Aflatoxin B1 results in decreased methylation of ABCB11 gene			[70]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Aflatoxin B1 results in increased expression of ABCB11 mRNA			[46]
Regulation Mechanism				Transcription Factor Info
Acute Toxic Substance
Morin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Morin inhibits the activity of ABCB11			[26]
2-methyl-4-isothiazolin-3-one	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	2-methyl-4-isothiazolin-3-one increases the expression of ABCB11			[57]
Carcinogen
Benzo(a)pyrene	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Benzo(a)pyrene inhibits the expression of ABCB11			[58]
Health and Environmental Toxicant
Pirinixic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Pirinixic acid inhibits the activity of ABCB11			[21]
Perfluorooctane sulfonic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Perfluorooctane sulfonic acid inhibits the expression of ABCB11			[51]
Diethylhexyl Phthalate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Diethylhexyl Phthalate inhibits the expression of ABCB11			[56]

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