Detail Information of Exogenous Modulation

General Information of Drug Transporter (DT)
DT ID	DTD0013 Transporter Info
Gene Name	ABCB4
Transporter Name	Multidrug resistance protein 3
Gene ID	5244
UniProt ID	P21439

Exogenous factors (drugs, dietary constituents, etc.) Modulation of This DT (EGM)
Nanoparticle
perfluoro-n-nonanoic acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	perfluoro-n-nonanoic acid results in increased expression of ABCB4 mRNA		[27]
Regulation Mechanism			Transcription Factor Info
Approved Drug
Cyclosporine	4 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Cyclosporine inhibits the activity of ABCB4		[1]
Cell System	Spodoptera frugiperda (Sf9) cells-MDR3
Paclitaxel	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Paclitaxel inhibits the activity of ABCB4		[1]
Cell System	Spodoptera frugiperda (Sf9) cells-MDR3
Verapamil	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Verapamil inhibits the activity of ABCB4		[1]
Cell System	Spodoptera frugiperda (Sf9) cells-MDR3
Vinblastine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Vinblastine inhibits the activity of ABCB4		[1]
Cell System	Spodoptera frugiperda (Sf9) cells-MDR3
Omeprazole	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Omeprazole inhibits the expression of ABCB4		[2]
Diclofenac	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Diclofenac inhibits the expression of ABCB4		[3]
Fenofibrate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Fenofibrate increases the expression of ABCB4		[4]
Copper Sulfate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Copper Sulfate inhibits the expression of ABCB4		[5]
Estradiol	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Estradiol inhibits the expression of ABCB4		[6]
Tretinoin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Tretinoin increases the expression of ABCB4		[7]
Isoproterenol	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Isoproterenol inhibits the expression of ABCB4		[8]
Ritonavir	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Ritonavir inhibits the expression of ABCB4		[9]
Vorinostat	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Vorinostat increases the expression of ABCB4		[10]
Rifampin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Rifampin increases the expression of ABCB4		[11]
Arsenic Trioxide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Arsenic Trioxide increases the expression of ABCB4		[12]
Obeticholic acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Obeticholic acid increases the expression of ABCB4		[13]
Benzatropine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Benzatropine inhibits the activity of ABCB4		[14]
Bicalutamide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Bicalutamide inhibits the activity of ABCB4		[14]
Biperiden	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Biperiden inhibits the activity of ABCB4		[14]
Chlorpheniramine	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Chlorpheniramine inhibits the activity of ABCB4		[14]
Clemastine	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Clemastine inhibits the activity of ABCB4		[14]
Dihydroergotamine	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Dihydroergotamine inhibits the activity of ABCB4		[14]
Esmolol	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Esmolol inhibits the activity of ABCB4		[14]
Flutamide	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Flutamide inhibits the activity of ABCB4		[14]
Fluvoxamine	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Fluvoxamine inhibits the activity of ABCB4		[14]
Hydroxyzine	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Hydroxyzine inhibits the activity of ABCB4		[14]
Ketoconazole	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Ketoconazole inhibits the activity of ABCB4		[14]
Labetalol	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Labetalol inhibits the activity of ABCB4		[14]
Lapatinib	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Lapatinib inhibits the activity of ABCB4		[14]
Leflunomide	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Leflunomide inhibits the activity of ABCB4		[14]
Liothyronine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Liothyronine inhibits the activity of ABCB4		[14]
Loratadine	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Loratadine inhibits the activity of ABCB4		[14]
Methotrexate	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Methotrexate inhibits the activity of ABCB4		[14]
Methysergide	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Methysergide inhibits the activity of ABCB4		[14]
Nefazodone	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Nefazodone inhibits the activity of ABCB4		[14]
Nitrofurantoin	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Nitrofurantoin inhibits the activity of ABCB4		[14]
Nortriptyline	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Nortriptyline inhibits the activity of ABCB4		[14]
Pazopanib	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Pazopanib inhibits the activity of ABCB4		[14]
Penbutolol	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Penbutolol inhibits the activity of ABCB4		[14]
Phenoxybenzamine	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Phenoxybenzamine inhibits the activity of ABCB4		[14]
Phentolamine	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Phentolamine inhibits the activity of ABCB4		[14]
Primaquine	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Primaquine inhibits the activity of ABCB4		[14]
Protriptyline	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Protriptyline inhibits the activity of ABCB4		[14]
Tacrine	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Tacrine inhibits the activity of ABCB4		[14]
Tamoxifen	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Tamoxifen inhibits the activity of ABCB4		[14]
Tamsulosin	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Tamsulosin inhibits the activity of ABCB4		[14]
Tenofovir	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Tenofovir inhibits the activity of ABCB4		[14]
Tipranavir	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Tipranavir inhibits the activity of ABCB4		[14]
Troglitazone	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Troglitazone inhibits the activity of ABCB4		[14]
Zafirlukast	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Zafirlukast inhibits the activity of ABCB4		[14]
Methoxsalen	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Methoxsalen inhibits the expression of ABCB4		[15]
Bosentan	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Bosentan inhibits the expression of ABCB4		[16]
Chenodeoxycholic acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Chenodeoxycholic acid increases the expression of ABCB4		[17]
Acetaminophen	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Acetaminophen inhibits the expression of ABCB4		[18]
DT Modulation2	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Acetaminophen results in decreased expression of ABCB4 mRNA		[35]
Regulation Mechanism			Transcription Factor Info
Valproic Acid	5 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Valproic Acid increases the expression of ABCB4		[19]
Doxorubicin	4 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Doxorubicin induces the activity of ABCB4		[20], [21]
Bezafibrate	6 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Bezafibrate induces the activity of ABCB4		[22]
Simvastatin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Simvastatin induces the activity of ABCB4		[23]
Phenobarbital	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Phenobarbital induces the activity of ABCB4		[24]
Drug Marketed but not Approved by US FDA
Benzbromarone	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Benzbromarone inhibits the activity of ABCB4		[14]
Drug in Phase 3 Trial
Triclosan	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Triclosan increases the expression of ABCB4		[30]
Drug in Phase 2 Trial
Colforsin	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Colforsin inhibits the expression of ABCB4		[21]
MS-275	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	MS-275 increases the expression of ABCB4		[10]
Drug in Phase 1 Trial
Tetradecanoylphorbol Acetate	4 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Tetradecanoylphorbol Acetate inhibits the expression of ABCB4		[20]
Quercetin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Quercetin inhibits the expression of ABCB4		[26]
ANA-756	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	ANA-756 inhibits the activity of ABCB4		[14]
Phenazopyridine	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Phenazopyridine inhibits the activity of ABCB4		[14]
WSM-3978G	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	WSM-3978G inhibits the activity of ABCB4		[14]
Sodium arsenite	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Sodium arsenite inhibits the expression of ABCB4		[29]
Drug in Preclinical Test
(+)-JQ1	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	(+)-JQ1 inhibits the expression of ABCB4		[28]
Patented Pharmaceutical Agent
GW-4064	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	GW-4064 inhibits the expression of ABCB4		[25]
Regulation Mechanism	via enhancement of Bile acid receptor (NR1H4)		Transcription Factor Info
Cell System	Human invasive breast carcinoma of no special type cells (MCF-7)
Drug Withdrawn
Nomifensine	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Nomifensine inhibits the activity of ABCB4		[14]
Zimeldine	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Zimeldine inhibits the activity of ABCB4		[14]
Natural Product
Methyleugenol	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Methyleugenol inhibits the expression of ABCB4		[31]
Mycotoxins
Aflatoxin B1	3 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Aflatoxin B1 affects the expression of ABCB4		[6]
DT Modulation2	Aflatoxin B1 co-treated with finrozole results in increased expression of ABCB4 mRNA		[36]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	Aflatoxin B1 results in decreased methylation of ABCB4 gene		[37]
Regulation Mechanism			Transcription Factor Info
aflatoxin B2	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	aflatoxin B2 results in decreased methylation of ABCB4 intron		[38]
Regulation Mechanism			Transcription Factor Info
Carcinogen
Benzo(a)pyrene	5 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Benzo(a)pyrene inhibits the expression of ABCB4		[31]
Health and Environmental Toxicant
Perfluorooctane sulfonic acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Perfluorooctane sulfonic acid increases the expression of ABCB4		[27]
Chemical Compound
DT Modulation1	Cyclosporine results in decreased expression of ABCB4 mRNA		[6]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Cyclosporine results in increased expression of ABCB4 mRNA		[49]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Cyclosporine results in decreased expression of ABCB4 mRNA		[35]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	ABCB4 protein results in decreased susceptibility to Paclitaxel		[59]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Verapamil results in decreased activity of ABCB4 protein		[14]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Verapamil results in decreased expression of ABCB4 mRNA		[15]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Diclofenac results in decreased activity of ABCB4 protein		[14]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Ritonavir results in decreased activity of ABCB4 protein		[14]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Biperiden results in decreased activity of ABCB4 protein		[14]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Chlorpheniramine results in decreased activity of ABCB4 protein		[14]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Clemastine results in decreased activity of ABCB4 protein		[14]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Dihydroergotamine results in decreased activity of ABCB4 protein		[14]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Flutamide results in decreased activity of ABCB4 protein		[14]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Fluvoxamine results in decreased activity of ABCB4 protein		[14]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Hydroxyzine results in decreased activity of ABCB4 protein		[14]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Ketoconazole results in decreased activity of ABCB4 protein		[14]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Labetalol results in decreased activity of ABCB4 protein		[14]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Lapatinib results in decreased activity of ABCB4 protein		[14]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Leflunomide results in decreased activity of ABCB4 protein		[14]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Loratadine results in decreased activity of ABCB4 protein		[14]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Methotrexate results in decreased activity of ABCB4 protein		[14]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Methotrexate results in increased expression of ABCB4 mRNA		[56]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Methysergide results in decreased activity of ABCB4 protein		[14]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Nitrofurantoin results in decreased activity of ABCB4 protein		[14]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Nortriptyline results in decreased activity of ABCB4 protein		[14]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Penbutolol results in decreased activity of ABCB4 protein		[14]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Phenoxybenzamine results in decreased activity of ABCB4 protein		[14]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Phentolamine results in decreased activity of ABCB4 protein		[14]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Primaquine results in decreased activity of ABCB4 protein		[14]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Protriptyline results in decreased activity of ABCB4 protein		[14]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Tacrine results in decreased activity of ABCB4 protein		[14]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Tamoxifen results in decreased activity of ABCB4 protein		[14]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Tamsulosin results in decreased activity of ABCB4 protein		[14]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Tenofovir results in decreased activity of ABCB4 protein		[14]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Troglitazone results in decreased activity of ABCB4 protein		[14]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Troglitazone results in increased expression of ABCB4 mRNA		[3]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Benzbromarone results in decreased activity of ABCB4 protein		[14]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of ABCB4 mRNA		[10]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Valproic Acid affects the expression of ABCB4 mRNA		[65]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	Valproic Acid results in decreased activity of ABCB4 protein		[39]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	Valproic Acid results in decreased methylation of ABCB4 gene		[19]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	ABCB4 protein results in decreased susceptibility to Doxorubicin		[51]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Colforsin inhibits the reaction Doxorubicin results in increased expression of ABCB4 mRNA		[21]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	Doxorubicin results in increased expression of ABCB4 mRNA		[52]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Bezafibrate affects the localization of ABCB4 protein		[43]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Bezafibrate co-treated with Chenodeoxycholic Acid results in increased expression of ABCB4 mRNA		[44]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	Bezafibrate results in increased expression of ABCB4 mRNA		[43]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	Bezafibrate results in increased expression of ABCB4 protein		[44]
Regulation Mechanism			Transcription Factor Info
DT Modulation5	PPARA protein affects the reaction Bezafibrate affects the localization of ABCB4 protein		[43]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Phenobarbital results in decreased expression of ABCB4 protein		[61]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	bisindolylmaleimide I inhibits the reaction Tetradecanoylphorbol Acetate results in decreased expression of ABCB4 mRNA		[20]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	calphostin C inhibits the reaction Tetradecanoylphorbol Acetate results in decreased expression of ABCB4 mRNA		[20]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	Cycloheximide inhibits the reaction Tetradecanoylphorbol Acetate results in decreased expression of ABCB4 mRNA		[20]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Colforsin inhibits the reaction Doxorubicin results in increased expression of ABCB4 mRNA		[21]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction Colforsin results in decreased expression of ABCB4 mRNA		[21]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Phenazopyridine results in decreased activity of ABCB4 protein		[14]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Nomifensine results in decreased activity of ABCB4 protein		[14]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Zimeldine results in decreased activity of ABCB4 protein		[14]
Regulation Mechanism			Transcription Factor Info
DT Modulation1	Benzo(a)pyrene affects the methylation of ABCB4 intron		[38]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Benzo(a)pyrene results in increased expression of ABCB4 mRNA		[41]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	Benzo(a)pyrene results in increased methylation of ABCB4 5' UTR		[42]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	Benzo(a)pyrene results in increased methylation of ABCB4 promoter		[42]
Regulation Mechanism			Transcription Factor Info
Gold	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Gold inhibits the expression of ABCB4		[32]
DT Modulation2	Polyethyleneimine binds to Gold which results in decreased expression of ABCB4 mRNA		[53]
Regulation Mechanism			Transcription Factor Info
1-Naphthylisothiocyanate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	1-Naphthylisothiocyanate co-treated with Cholic Acids affects the expression of ABCB4 mRNA		[33]
Regulation Mechanism			Transcription Factor Info
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of ABCB4 mRNA		[10]
Regulation Mechanism			Transcription Factor Info
abrine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	abrine results in decreased expression of ABCB4 mRNA		[34]
Regulation Mechanism			Transcription Factor Info
Amodiaquine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Amodiaquine results in decreased activity of ABCB4 protein		[39]
Regulation Mechanism			Transcription Factor Info
Atazanavir Sulfate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Atazanavir Sulfate results in decreased expression of ABCB4 mRNA		[35]
Regulation Mechanism			Transcription Factor Info
Beclomethasone	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Beclomethasone results in increased expression of ABCB4 mRNA		[40]
Regulation Mechanism			Transcription Factor Info
benzarone	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	benzarone results in decreased activity of ABCB4 protein		[14]
Regulation Mechanism			Transcription Factor Info
benziodarone	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	benziodarone results in decreased activity of ABCB4 protein		[14]
Regulation Mechanism			Transcription Factor Info
benzo(e)pyrene	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	benzo(e)pyrene results in decreased methylation of ABCB4 intron		[38]
Regulation Mechanism			Transcription Factor Info
Benztropine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Benztropine results in decreased activity of ABCB4 protein		[14]
Regulation Mechanism			Transcription Factor Info
bicalutamide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	bicalutamide results in decreased activity of ABCB4 protein		[14]
Regulation Mechanism			Transcription Factor Info
bisindolylmaleimide I	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	bisindolylmaleimide I inhibits the reaction Tetradecanoylphorbol Acetate results in decreased expression of ABCB4 mRNA		[20]
Regulation Mechanism			Transcription Factor Info
bisphenol F	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	bisphenol F co-treated with Fulvestrant results in increased methylation of ABCB4 gene		[45]
Regulation Mechanism			Transcription Factor Info
Brompheniramine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Brompheniramine results in decreased activity of ABCB4 protein		[14]
Regulation Mechanism			Transcription Factor Info
calphostin C	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	calphostin C inhibits the reaction Tetradecanoylphorbol Acetate results in decreased expression of ABCB4 mRNA		[20]
Regulation Mechanism			Transcription Factor Info
carbetapentane	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	carbetapentane results in decreased activity of ABCB4 protein		[14]
Regulation Mechanism			Transcription Factor Info
Chenodeoxycholic Acid	9 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Bezafibrate co-treated with Chenodeoxycholic Acid results in increased expression of ABCB4 mRNA		[44]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Chenodeoxycholic Acid binds to and results in increased activity of NR1H4 protein which binds to ABCB4 promoter which results in increased expression of ABCB4 mRNA		[46]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	Chenodeoxycholic Acid results in increased expression of ABCB4 mRNA		[46]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Acetaminophen results in decreased expression of ABCB4 mRNA		[35]
Regulation Mechanism			Transcription Factor Info
DT Modulation5	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Atazanavir Sulfate results in decreased expression of ABCB4 mRNA		[35]
Regulation Mechanism			Transcription Factor Info
DT Modulation6	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Cyclosporine results in decreased expression of ABCB4 mRNA		[35]
Regulation Mechanism			Transcription Factor Info
DT Modulation7	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with nefazodone results in increased expression of ABCB4 mRNA		[35]
Regulation Mechanism			Transcription Factor Info
DT Modulation8	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Tartrazine results in decreased expression of ABCB4 mRNA		[35]
Regulation Mechanism			Transcription Factor Info
DT Modulation9	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid results in increased expression of ABCB4 mRNA		[35]
Regulation Mechanism			Transcription Factor Info
Chlorpromazine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Chlorpromazine co-treated with Cholic Acids affects the expression of ABCB4 mRNA		[33]
Regulation Mechanism			Transcription Factor Info
chlortoluron	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	chlortoluron results in decreased expression of ABCB4 mRNA		[47]
Regulation Mechanism			Transcription Factor Info
Clavulanic Acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Clavulanic Acid results in decreased expression of ABCB4 mRNA		[48]
Regulation Mechanism			Transcription Factor Info
Clopidogrel	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Clopidogrel results in decreased activity of ABCB4 protein		[39]
Regulation Mechanism			Transcription Factor Info
Clozapine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Clozapine results in decreased activity of ABCB4 protein		[39]
Regulation Mechanism			Transcription Factor Info
Cycloheximide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Cycloheximide inhibits the reaction Tetradecanoylphorbol Acetate results in decreased expression of ABCB4 mRNA		[20]
Regulation Mechanism			Transcription Factor Info
Deoxycholic Acid	6 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Acetaminophen results in decreased expression of ABCB4 mRNA		[35]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Atazanavir Sulfate results in decreased expression of ABCB4 mRNA		[35]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Cyclosporine results in decreased expression of ABCB4 mRNA		[35]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with nefazodone results in increased expression of ABCB4 mRNA		[35]
Regulation Mechanism			Transcription Factor Info
DT Modulation5	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Tartrazine results in decreased expression of ABCB4 mRNA		[35]
Regulation Mechanism			Transcription Factor Info
DT Modulation6	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid results in increased expression of ABCB4 mRNA		[35]
Regulation Mechanism			Transcription Factor Info
Docetaxel	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Docetaxel results in decreased susceptibility to Docetaxel which results in increased expression of ABCB4 mRNA		[50]
Regulation Mechanism			Transcription Factor Info
dorsomorphin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of ABCB4 mRNA		[10]
Regulation Mechanism			Transcription Factor Info
Doxylamine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Doxylamine results in decreased activity of ABCB4 protein		[14]
Regulation Mechanism			Transcription Factor Info
ebrotidine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	ebrotidine results in decreased activity of ABCB4 protein		[14]
Regulation Mechanism			Transcription Factor Info
entinostat	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	entinostat results in increased expression of ABCB4 mRNA		[10]
Regulation Mechanism			Transcription Factor Info
esmolol	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	esmolol results in decreased activity of ABCB4 protein		[14]
Regulation Mechanism			Transcription Factor Info
Ethinyl Estradiol	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Ethinyl Estradiol co-treated with Cholic Acids affects the expression of ABCB4 mRNA		[33]
Regulation Mechanism			Transcription Factor Info
finrozole	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Aflatoxin B1 co-treated with finrozole results in increased expression of ABCB4 mRNA		[36]
Regulation Mechanism			Transcription Factor Info
fipexide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	fipexide results in decreased activity of ABCB4 protein		[14]
Regulation Mechanism			Transcription Factor Info
Fulvestrant	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	bisphenol F co-treated with Fulvestrant results in increased methylation of ABCB4 gene		[45]
Regulation Mechanism			Transcription Factor Info
Glycochenodeoxycholic Acid	6 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Acetaminophen results in decreased expression of ABCB4 mRNA		[35]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Atazanavir Sulfate results in decreased expression of ABCB4 mRNA		[35]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Cyclosporine results in decreased expression of ABCB4 mRNA		[35]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with nefazodone results in increased expression of ABCB4 mRNA		[35]
Regulation Mechanism			Transcription Factor Info
DT Modulation5	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Tartrazine results in decreased expression of ABCB4 mRNA		[35]
Regulation Mechanism			Transcription Factor Info
DT Modulation6	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid results in increased expression of ABCB4 mRNA		[35]
Regulation Mechanism			Transcription Factor Info
Glycocholic Acid	6 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Acetaminophen results in decreased expression of ABCB4 mRNA		[35]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Atazanavir Sulfate results in decreased expression of ABCB4 mRNA		[35]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Cyclosporine results in decreased expression of ABCB4 mRNA		[35]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with nefazodone results in increased expression of ABCB4 mRNA		[35]
Regulation Mechanism			Transcription Factor Info
DT Modulation5	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Tartrazine results in decreased expression of ABCB4 mRNA		[35]
Regulation Mechanism			Transcription Factor Info
DT Modulation6	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid results in increased expression of ABCB4 mRNA		[35]
Regulation Mechanism			Transcription Factor Info
Glycodeoxycholic Acid	6 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Acetaminophen results in decreased expression of ABCB4 mRNA		[35]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Atazanavir Sulfate results in decreased expression of ABCB4 mRNA		[35]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Cyclosporine results in decreased expression of ABCB4 mRNA		[35]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with nefazodone results in increased expression of ABCB4 mRNA		[35]
Regulation Mechanism			Transcription Factor Info
DT Modulation5	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Tartrazine results in decreased expression of ABCB4 mRNA		[35]
Regulation Mechanism			Transcription Factor Info
DT Modulation6	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid results in increased expression of ABCB4 mRNA		[35]
Regulation Mechanism			Transcription Factor Info
Guanethidine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Guanethidine results in decreased activity of ABCB4 protein		[14]
Regulation Mechanism			Transcription Factor Info
GW 4064	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	GW 4064 binds to and results in increased activity of NR1H4 protein which binds to ABCB4 promoter which results in increased expression of ABCB4 mRNA		[46]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	GW 4064 results in increased expression of ABCB4 mRNA		[46]
Regulation Mechanism			Transcription Factor Info
Indomethacin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Indomethacin results in decreased activity of ABCB4 protein		[39]
Regulation Mechanism			Transcription Factor Info
licochalcone B	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	licochalcone B results in increased expression of ABCB4 mRNA		[54]
Regulation Mechanism			Transcription Factor Info
Methapyrilene	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Methapyrilene results in decreased expression of ABCB4 mRNA		[55]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Methapyrilene results in decreased methylation of ABCB4 intron		[38]
Regulation Mechanism			Transcription Factor Info
methyleugenol	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	methyleugenol results in decreased expression of ABCB4 mRNA		[31]
Regulation Mechanism			Transcription Factor Info
Methyltestosterone	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Methyltestosterone co-treated with Cholic Acids affects the expression of ABCB4 mRNA		[33]
Regulation Mechanism			Transcription Factor Info
monomethylarsonous acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	monomethylarsonous acid results in decreased expression of ABCB4 mRNA		[57]
Regulation Mechanism			Transcription Factor Info
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction Colforsin results in decreased expression of ABCB4 mRNA		[21]
Regulation Mechanism			Transcription Factor Info
nefazodone	2 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with nefazodone results in increased expression of ABCB4 mRNA		[35]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	nefazodone results in decreased activity of ABCB4 protein		[14]
Regulation Mechanism			Transcription Factor Info
N-Nitrosopyrrolidine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	N-Nitrosopyrrolidine results in decreased expression of ABCB4 mRNA		[31]
Regulation Mechanism			Transcription Factor Info
obeticholic acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	obeticholic acid results in increased expression of ABCB4 mRNA		[13]
Regulation Mechanism			Transcription Factor Info
Okadaic Acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Okadaic Acid results in decreased expression of ABCB4 mRNA		[58]
Regulation Mechanism			Transcription Factor Info
oxybutynin	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	oxybutynin results in decreased activity of ABCB4 protein		[14]
Regulation Mechanism			Transcription Factor Info
Paliperidone Palmitate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Paliperidone Palmitate results in decreased activity of ABCB4 protein		[14]
Regulation Mechanism			Transcription Factor Info
pazopanib	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	pazopanib results in decreased activity of ABCB4 protein		[14]
Regulation Mechanism			Transcription Factor Info
perfluorohexanesulfonic acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	perfluorohexanesulfonic acid results in increased expression of ABCB4 mRNA		[27]
Regulation Mechanism			Transcription Factor Info
perfluoro-n-heptanoic acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	perfluoro-n-heptanoic acid results in increased expression of ABCB4 mRNA		[27]
Regulation Mechanism			Transcription Factor Info
perfluorooctane sulfonic acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	perfluorooctane sulfonic acid results in increased expression of ABCB4 mRNA		[27]
Regulation Mechanism			Transcription Factor Info
perfluorooctanoic acid	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	perfluorooctanoic acid results in increased expression of ABCB4 mRNA		[60]
Regulation Mechanism			Transcription Factor Info
Perhexiline	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Perhexiline results in decreased activity of ABCB4 protein		[14]
Regulation Mechanism			Transcription Factor Info
Phosphatidylcholines	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	ABCB4 protein affects the export of Phosphatidylcholines		[62]
Regulation Mechanism			Transcription Factor Info
Pioglitazone	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Pioglitazone results in decreased activity of ABCB4 protein		[39]
Regulation Mechanism			Transcription Factor Info
Procyclidine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Procyclidine results in decreased activity of ABCB4 protein		[14]
Regulation Mechanism			Transcription Factor Info
S-(1,2-dichlorovinyl)cysteine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	S-(1,2-dichlorovinyl)cysteine co-treated with Lipopolysaccharides results in decreased expression of ABCB4 mRNA		[63]
Regulation Mechanism			Transcription Factor Info
sodium arsenite	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	sodium arsenite results in decreased expression of ABCB4 mRNA		[29]
Regulation Mechanism			Transcription Factor Info
Tartrazine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Tartrazine results in decreased expression of ABCB4 mRNA		[35]
Regulation Mechanism			Transcription Factor Info
tasosartan	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	tasosartan results in decreased activity of ABCB4 protein		[14]
Regulation Mechanism			Transcription Factor Info
Theophylline	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Theophylline results in decreased activity of ABCB4 protein		[39]
Regulation Mechanism			Transcription Factor Info
Ticlopidine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Ticlopidine results in decreased activity of ABCB4 protein		[39]
Regulation Mechanism			Transcription Factor Info
tipranavir	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	tipranavir results in decreased activity of ABCB4 protein		[14]
Regulation Mechanism			Transcription Factor Info
Tolterodine Tartrate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Tolterodine Tartrate results in decreased activity of ABCB4 protein		[14]
Regulation Mechanism			Transcription Factor Info
Triiodothyronine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Triiodothyronine results in decreased activity of ABCB4 protein		[14]
Regulation Mechanism			Transcription Factor Info
triphenyl phosphate	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	triphenyl phosphate affects the expression of ABCB4 mRNA		[64]
Regulation Mechanism			Transcription Factor Info
Valsartan	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Valsartan results in decreased activity of ABCB4 protein		[39]
Regulation Mechanism			Transcription Factor Info
Vincristine	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Vincristine results in decreased susceptibility to Vincristine which affects the expression of ABCB4 mRNA		[50]
Regulation Mechanism			Transcription Factor Info
Y 27632	12 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	Y 27632 inhibits the reaction ABCB4 gene mutant form results in increased expression of COL1A1 mRNA		[66]
Regulation Mechanism			Transcription Factor Info
DT Modulation2	Y 27632 inhibits the reaction ABCB4 gene mutant form results in increased expression of COL1A2 mRNA		[66]
Regulation Mechanism			Transcription Factor Info
DT Modulation3	Y 27632 inhibits the reaction ABCB4 gene mutant form results in increased expression of COL3A1 mRNA		[66]
Regulation Mechanism			Transcription Factor Info
DT Modulation4	Y 27632 inhibits the reaction ABCB4 gene mutant form results in increased expression of COL4A1 mRNA		[66]
Regulation Mechanism			Transcription Factor Info
DT Modulation5	Y 27632 inhibits the reaction ABCB4 gene mutant form results in increased expression of COL5A1 mRNA		[66]
Regulation Mechanism			Transcription Factor Info
DT Modulation6	Y 27632 inhibits the reaction ABCB4 gene mutant form results in increased expression of COL6A1 mRNA		[66]
Regulation Mechanism			Transcription Factor Info
DT Modulation7	Y 27632 inhibits the reaction ABCB4 gene mutant form results in increased expression of ELN mRNA		[66]
Regulation Mechanism			Transcription Factor Info
DT Modulation8	Y 27632 inhibits the reaction ABCB4 gene mutant form results in increased expression of FN1 mRNA		[66]
Regulation Mechanism			Transcription Factor Info
DT Modulation9	Y 27632 inhibits the reaction ABCB4 gene mutant form results in increased expression of MMP14 mRNA		[66]
Regulation Mechanism			Transcription Factor Info
DT Modulation10	Y 27632 inhibits the reaction ABCB4 gene mutant form results in increased expression of MMP2 mRNA		[66]
Regulation Mechanism			Transcription Factor Info
DT Modulation11	Y 27632 inhibits the reaction ABCB4 gene mutant form results in increased expression of PDGFB mRNA		[66]
Regulation Mechanism			Transcription Factor Info
DT Modulation12	Y 27632 inhibits the reaction ABCB4 gene mutant form results in increased expression of TGFB1 mRNA		[66]
Regulation Mechanism			Transcription Factor Info
zafirlukast	1 DT Activity Modulations Related to This Exogenous Factor	Click to Show/Hide the Full List
DT Modulation1	zafirlukast results in decreased activity of ABCB4 protein		[14]
Regulation Mechanism			Transcription Factor Info

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10	Definition of transcriptome-based indices for quantitative characterization of chemically disturbed stem cell development: introduction of the STOP-Toxukn and STOP-Toxukk tests. Arch Toxicol. 2017 Feb;91(2):839-864.
11	Rifampin Regulation of Drug Transporters Gene Expression and the Association of MicroRNAs in Human Hepatocytes. Front Pharmacol. 2016 Apr 26;7:111.
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