Detail Information of Exogenous Modulation
| General Information of Drug Transporter (DT) | |||||
|---|---|---|---|---|---|
| DT ID | DTD0012 Transporter Info | ||||
| Gene Name | ABCC3 | ||||
| Transporter Name | Multidrug resistance-associated protein 3 | ||||
| Gene ID | |||||
| UniProt ID | |||||
| Exogenous factors (drugs, dietary constituents, etc.) Modulation of This DT (EGM) | |||||
|---|---|---|---|---|---|
Chemical Compound |
|||||
DT Modulation1 |
ABCC3 protein results in decreased susceptibility to Doxorubicin | [125] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
Doxorubicin results in increased nitrosation of ABCC3 protein | [98] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation3 |
Simvastatin promotes the reaction Doxorubicin results in increased nitrosation of ABCC3 protein | [98] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Rifampin inhibits the reaction Decitabine results in increased expression of ABCC3 mRNA | [9] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
ABCC3 protein results in increased uptake of Estradiol | [127] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
Cycloheximide co-treated with Estradiol results in increased expression of ABCC3 mRNA | [49] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation3 |
Estradiol co-treated with Tetrachlorodibenzodioxin results in increased expression of ABCC3 mRNA | [128] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation4 |
Estradiol results in increased expression of ABCC3 mRNA | [128] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation5 |
Progesterone co-treated with Estradiol results in decreased expression of ABCC3 mRNA | [129] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Indomethacin inhibits the reaction ABCC3 protein affects the export of 5-carboxyfluorescein diacetate | [81] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
Indomethacin inhibits the reaction ABCC3 protein affects the transport of estradiol-17 beta-glucuronide | [132] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation3 |
INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A results in decreased expression of ABCC3 mRNA | [77] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation4 |
INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F results in decreased expression of ABCC3 mRNA | [77] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation5 |
INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S results in decreased expression of ABCC3 mRNA | [77] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Acetylcysteine inhibits the reaction Sulindac results in increased expression of ABCC3 protein | [12] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
ABCC3 mRNA affects the susceptibility to Cisplatin | [111] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
ABCC3 protein results in decreased susceptibility to Cisplatin | [112] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Progesterone co-treated with Estradiol results in decreased expression of ABCC3 mRNA | [129] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
ABCC3 protein results in decreased susceptibility to Arsenic Trioxide | [97] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Tolvaptan metabolite results in decreased activity of ABCC3 protein | [26] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
MAPK14 promotes the reaction Clotrimazole results in increased expression of ABCC3 mRNA | [27] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
SB 203580 inhibits the reaction Clotrimazole results in increased expression of ABCC3 mRNA | [27] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Valproic Acid affects the expression of ABCC3 mRNA | [157] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
Valproic Acid results in decreased methylation of ABCC3 gene | [30] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation3 |
Valproic Acid results in increased expression of ABCC3 mRNA | [158] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation4 |
Valproic Acid results in increased expression of ABCC3 protein | [30] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Meclizine promotes the reaction Ethanol results in increased expression of ABCC3 mRNA | [35] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Cyclosporine affects the expression of ABCC3 mRNA | [117] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
Cyclosporine co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid results in decreased expression of ABCC3 mRNA | [34] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation3 |
Cyclosporine inhibits the reaction ABCC3 protein affects the export of 5-carboxyfluorescein diacetate | [81] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation4 |
Cyclosporine results in increased expression of ABCC3 mRNA | [118] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
ABCC3 gene mutant form affects the susceptibility to Methotrexate | [138] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
ABCC3 gene SNP affects the susceptibility to Methotrexate | [139] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation3 |
Methotrexate affects the expression of ABCC3 mRNA | [140] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
ABCC3 protein results in decreased susceptibility to Etoposide | [131] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Phenobarbital results in increased expression of ABCC3 protein | [144] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Cycloheximide co-treated with Estradiol results in increased expression of ABCC3 mRNA | [49] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
4-cresylglucuronide promotes the reaction ABCC3 protein results in increased uptake of Taurocholic Acid | [133] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
ABCC3 protein results in increased uptake of Taurocholic Acid | [133] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation3 |
hippuric acid promotes the reaction ABCC3 protein results in increased uptake of Taurocholic Acid | [133] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation4 |
Taurocholic Acid results in increased activity of ABCC3 protein | [52] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
SB 203580 inhibits the reaction Anisomycin results in increased expression of ABCC3 mRNA | [27] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
TAK-875 analog results in decreased activity of ABCC3 protein | [66] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
TAK-875 inhibits the reaction ABCC3 protein results in increased transport of Bile Acids and Salts | [154] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation3 |
TAK-875 results in decreased activity of ABCC3 protein | [154] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Triclosan results in decreased expression of ABCC3 mRNA | [155] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Meclizine promotes the reaction Ethanol results in increased expression of ABCC3 mRNA | [35] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
NR1I2 protein affects the reaction Ethanol results in increased expression of ABCC3 mRNA | [35] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation1 |
Benzo(a)pyrene results in decreased methylation of ABCC3 3' UTR | [100] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
Benzo(a)pyrene results in increased methylation of ABCC3 promoter | [100] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
15-deoxy-delta(12,14)-prostaglandin J2 |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
ABCC3 protein affects the export of 15-deoxy-delta(12,14)-prostaglandin J2 analog | [75] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
1-Butanol |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Gasoline co-treated with 1-Butanol results in increased abundance of Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons which results in increased expression of ABCC3 mRNA | [76] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
1-Methyl-3-isobutylxanthine |
3 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A results in decreased expression of ABCC3 mRNA | [77] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F results in decreased expression of ABCC3 mRNA | [77] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation3 |
INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S results in decreased expression of ABCC3 mRNA | [77] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
2,5,2',5'-tetrachlorobiphenyl |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
2,5,2',5'-tetrachlorobiphenyl results in decreased expression of ABCC3 mRNA | [78] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
2-Acetylaminofluorene |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
2-Acetylaminofluorene results in increased expression of ABCC3 mRNA | [48] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
2-Acetylaminofluorene results in increased expression of ABCC3 protein | [48] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid results in increased expression of ABCC3 mRNA | [63] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
4-phenylenediamine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
4-phenylenediamine results in increased expression of ABCC3 mRNA | [79] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
5(6)-carboxy-2',7'-dichlorofluorescein |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
ABCC3 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein | [80] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
Benzbromarone inhibits the reaction ABCC3 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein | [80] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
5-carboxyfluorescein diacetate |
3 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Cyclosporine inhibits the reaction ABCC3 protein affects the export of 5-carboxyfluorescein diacetate | [81] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
Indomethacin inhibits the reaction ABCC3 protein affects the export of 5-carboxyfluorescein diacetate | [81] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation3 |
Verapamil inhibits the reaction ABCC3 protein affects the export of 5-carboxyfluorescein diacetate | [81] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide affects the expression of ABCC3 mRNA | [82] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased expression of ABCC3 protein | [82] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
acetaminophen glucuronide |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
acetaminophen glucuronide results in increased activity of ABCC3 protein | [52] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Acetylcysteine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Acetylcysteine inhibits the reaction Sulindac results in increased expression of ABCC3 protein | [12] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Acrolein |
3 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone results in increased expression of and results in increased oxidation of ABCC3 mRNA | [86] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
Acrolein co-treated with methacrylaldehyde co-treated with Ozone results in increased expression of ABCC3 mRNA | [87] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation3 |
Air Pollutants results in increased abundance of Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone which results in increased expression of and results in increased oxidation of ABCC3 mRNA | [86] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
afimoxifene |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
afimoxifene results in increased expression of ABCC3 mRNA | [49] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
afuresertib |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
afuresertib results in increased expression of ABCC3 mRNA | [90] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
allyl sulfide |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
allyl sulfide affects the expression of ABCC3 mRNA | [57] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
alpha-pinene |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone results in increased expression of and results in increased oxidation of ABCC3 mRNA | [86] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
Air Pollutants results in increased abundance of Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone which results in increased expression of and results in increased oxidation of ABCC3 mRNA | [86] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
ammonium 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)-propanoate |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
ammonium 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)-propanoate results in increased expression of ABCC3 mRNA | [91] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
antibiotic G 418 |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
ABCC3 protein results in increased transport of antibiotic G 418 | [92] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Antimony Potassium Tartrate |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Antimony Potassium Tartrate results in increased abundance of antimonite which results in increased expression of ABCC3 mRNA | [93] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
aristolochic acid I |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
aristolochic acid I results in increased expression of ABCC3 mRNA | [94] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
artemisinin |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
artemisinin inhibits the reaction Simvastatin results in increased nitrosation of ABCC3 protein | [98] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Atazanavir Sulfate |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Atazanavir Sulfate results in decreased expression of ABCC3 mRNA | [34] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Benzbromarone |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Benzbromarone inhibits the reaction ABCC3 protein results in increased transport of 5(6)-carboxy-2',7'-dichlorofluorescein | [80] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
yu ping feng san inhibits the reaction Benzbromarone results in increased activity of ABCC3 protein | [99] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
benzo(e)pyrene |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
benzo(e)pyrene results in increased methylation of ABCC3 intron | [88] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
bisphenol A |
4 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
bisphenol A affects the expression of ABCC3 mRNA | [101] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
bisphenol A results in increased expression of ABCC3 mRNA | [54] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation3 |
bisphenol A results in increased expression of ABCC3 protein | [54] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation4 |
INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A results in decreased expression of ABCC3 mRNA | [77] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
bisphenol A glucuronide |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
bisphenol A glucuronide binds to ABCC3 protein | [102] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
bisphenol F |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F results in decreased expression of ABCC3 mRNA | [77] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
bisphenol S |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S results in decreased expression of ABCC3 mRNA | [77] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Buserelin |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Buserelin co-treated with CGB3 protein results in increased expression of ABCC3 mRNA | [103] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
butylbenzyl phthalate |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
butylbenzyl phthalate results in increased expression of ABCC3 mRNA | [104] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
dimethyl phthalate co-treated with diethyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with Diethylhexyl Phthalate results in increased expression of ABCC3 mRNA | [104] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
butyraldehyde |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
butyraldehyde results in decreased expression of ABCC3 mRNA | [61] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Cadmium Chloride |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Cadmium Chloride results in decreased expression of ABCC3 mRNA | [25] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
Cadmium Chloride results in increased expression of ABCC3 mRNA | [105] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
calcein AM |
9 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
ABCC3 protein affects the transport of calcein AM | [106] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
ABCC3 protein results in increased transport of calcein AM | [107] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation3 |
Dexamethasone promotes the reaction ABCC3 protein affects the transport of calcein AM | [106] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation4 |
Glutathione promotes the reaction ABCC3 protein affects the transport of calcein AM | [108] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation5 |
Hydrocortisone promotes the reaction ABCC3 protein affects the transport of calcein AM | [106] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation6 |
Prednisone promotes the reaction ABCC3 protein affects the transport of calcein AM | [106] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation7 |
verlukast inhibits the reaction ABCC3 protein results in increased transport of calcein AM | [107] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation8 |
zearalenol inhibits the reaction ABCC3 protein results in increased transport of calcein AM | [107] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation9 |
Zearalenone inhibits the reaction ABCC3 protein results in increased transport of calcein AM | [107] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
calcipotriene |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
calcipotriene results in increased expression of ABCC3 protein | [31] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
VDR protein affects the reaction calcipotriene results in increased expression of ABCC3 protein | [31] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
cambinol |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
cambinol affects the expression of ABCC3 protein | [82] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
cambinol results in increased expression of ABCC3 mRNA | [82] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Chenodeoxycholic Acid |
6 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Chenodeoxycholic Acid results in increased expression of ABCC3 mRNA | [109] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
Cyclosporine co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid results in decreased expression of ABCC3 mRNA | [34] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation3 |
Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with 6-hydroxy-5-((p- sulfophenyl)azo)-2-naphthalenesulfonic acid disodium salt results in decreased expression of ABCC3 mRNA | [85] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation4 |
Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Acetaminophen results in decreased expression of ABCC3 mRNA | [85] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation5 |
Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Tartrazine results in decreased expression of ABCC3 mRNA | [85] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation6 |
nefazodone co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid results in decreased expression of ABCC3 mRNA | [34] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
chloroacetaldehyde |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
chloroacetaldehyde results in decreased expression of ABCC3 mRNA | [25] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
chrysin |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
ABCC3 protein affects the reaction chrysin results in increased transport of Glutathione | [110] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
cinnamaldehyde |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
cinnamaldehyde results in increased expression of ABCC3 mRNA | [55] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Clozapine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Clozapine results in decreased activity of ABCC3 protein | [83] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
cobaltous chloride |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
cobaltous chloride results in decreased expression of ABCC3 mRNA | [113] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
coniferaldehyde |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
coniferaldehyde results in increased expression of ABCC3 mRNA | [114] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Copper |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
NSC 689534 binds to Copper which results in increased expression of ABCC3 mRNA | [115] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
cupric chloride |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
cupric chloride results in increased expression of ABCC3 mRNA | [116] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
cyproconazole |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
NR1I2 protein co-treated with NR1I3 protein affects the reaction cyproconazole results in increased expression of ABCC3 mRNA | [119] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
NR1I2 protein co-treated with NR1I3 protein affects the reaction cyproconazole results in increased expression of ABCC3 protein | [119] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Deoxycholic Acid |
7 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Cyclosporine co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid results in decreased expression of ABCC3 mRNA | [34] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
Deoxycholic Acid results in increased activity of ABCC3 protein | [52] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation3 |
Deoxycholic Acid results in increased expression of ABCC3 mRNA | [120] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation4 |
Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with 6-hydroxy-5-((p- sulfophenyl)azo)-2-naphthalenesulfonic acid disodium salt results in decreased expression of ABCC3 mRNA | [85] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation5 |
Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Acetaminophen results in decreased expression of ABCC3 mRNA | [85] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation6 |
Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Tartrazine results in decreased expression of ABCC3 mRNA | [85] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation7 |
nefazodone co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid results in decreased expression of ABCC3 mRNA | [34] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
deoxynivalenol |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
deoxynivalenol results in decreased expression of ABCC3 mRNA | [69] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Dexamethasone |
7 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Dexamethasone promotes the reaction ABCC3 protein affects the transport of calcein AM | [106] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
Dexamethasone results in increased activity of ABCC3 protein | [106] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation3 |
Dexamethasone results in increased expression of ABCC3 mRNA | [106] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation4 |
Dexamethasone results in increased expression of ABCC3 protein | [106] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation5 |
INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A results in decreased expression of ABCC3 mRNA | [77] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation6 |
INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F results in decreased expression of ABCC3 mRNA | [77] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation7 |
INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S results in decreased expression of ABCC3 mRNA | [77] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
diallyl disulfide |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
diallyl disulfide affects the expression of ABCC3 mRNA | [57] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
diallyl disulfide results in increased expression of ABCC3 mRNA | [57] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
diallyl trisulfide |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
diallyl trisulfide results in decreased expression of ABCC3 mRNA | [57] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
diallyl trisulfide results in increased expression of ABCC3 mRNA | [121] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Dibutyl Phthalate |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Dibutyl Phthalate results in increased expression of ABCC3 mRNA | [104] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
dimethyl phthalate co-treated with diethyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with Diethylhexyl Phthalate results in increased expression of ABCC3 mRNA | [104] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Diclofenac |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Diclofenac results in decreased activity of ABCC3 protein | [83] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Diethylhexyl Phthalate |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
dimethyl phthalate co-treated with diethyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with Diethylhexyl Phthalate results in increased expression of ABCC3 mRNA | [104] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
diethyl phthalate |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
diethyl phthalate results in increased expression of ABCC3 mRNA | [104] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
dimethyl phthalate co-treated with diethyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with Diethylhexyl Phthalate results in increased expression of ABCC3 mRNA | [104] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
diglycolic acid |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
diglycolic acid affects the expression of ABCC3 mRNA | [122] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Dimethylnitrosamine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Dimethylnitrosamine results in increased expression of ABCC3 mRNA | [51] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
dimethyl phthalate |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
dimethyl phthalate co-treated with diethyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with Diethylhexyl Phthalate results in increased expression of ABCC3 mRNA | [104] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
dimethyl phthalate results in increased expression of ABCC3 mRNA | [104] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
di-n-butylphosphoric acid |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
di-n-butylphosphoric acid affects the expression of ABCC3 mRNA | [123] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Docetaxel |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Docetaxel results in decreased susceptibility to Docetaxel which results in increased expression of ABCC3 mRNA | [124] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
erucylphospho-N,N,N-trimethylpropylammonium |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
erucylphospho-N,N,N-trimethylpropylammonium results in increased expression of ABCC3 mRNA | [126] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Erythromycin |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Erythromycin results in decreased activity of ABCC3 protein | [83] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Ethinyl Estradiol |
3 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
ABCC3 protein results in increased uptake of Ethinyl Estradiol metabolite | [130] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
Ethinyl Estradiol metabolite promotes the reaction ABCC3 protein results in increased uptake of estradiol-17 beta-glucuronide | [130] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation3 |
Ethinyl Estradiol results in decreased activity of ABCC3 protein | [83] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
ethinyl estradiol glucuronide |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
ethinyl estradiol glucuronide results in increased activity of ABCC3 protein | [52] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Fluoxetine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Fluoxetine results in decreased activity of ABCC3 protein | [83] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Furosemide |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Furosemide inhibits the reaction ABCC3 protein affects the transport of estradiol-17 beta-glucuronide | [132] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
Furosemide results in decreased activity of ABCC3 protein | [83] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Gasoline |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Gasoline co-treated with 1-Butanol results in increased abundance of Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons which results in increased expression of ABCC3 mRNA | [76] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Glutathione |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
ABCC3 protein affects the reaction chrysin results in increased transport of Glutathione | [110] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
Glutathione promotes the reaction ABCC3 protein affects the transport of calcein AM | [108] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Glycochenodeoxycholic Acid |
5 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Cyclosporine co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid results in decreased expression of ABCC3 mRNA | [34] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with 6-hydroxy-5-((p- sulfophenyl)azo)-2-naphthalenesulfonic acid disodium salt results in decreased expression of ABCC3 mRNA | [85] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation3 |
Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Acetaminophen results in decreased expression of ABCC3 mRNA | [85] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation4 |
Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Tartrazine results in decreased expression of ABCC3 mRNA | [85] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation5 |
nefazodone co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid results in decreased expression of ABCC3 mRNA | [34] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Glycocholic Acid |
5 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Cyclosporine co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid results in decreased expression of ABCC3 mRNA | [34] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with 6-hydroxy-5-((p- sulfophenyl)azo)-2-naphthalenesulfonic acid disodium salt results in decreased expression of ABCC3 mRNA | [85] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation3 |
Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Acetaminophen results in decreased expression of ABCC3 mRNA | [85] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation4 |
Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Tartrazine results in decreased expression of ABCC3 mRNA | [85] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation5 |
nefazodone co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid results in decreased expression of ABCC3 mRNA | [34] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Glycodeoxycholic Acid |
5 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Cyclosporine co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid results in decreased expression of ABCC3 mRNA | [34] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with 6-hydroxy-5-((p- sulfophenyl)azo)-2-naphthalenesulfonic acid disodium salt results in decreased expression of ABCC3 mRNA | [85] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation3 |
Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Acetaminophen results in decreased expression of ABCC3 mRNA | [85] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation4 |
Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Tartrazine results in decreased expression of ABCC3 mRNA | [85] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation5 |
nefazodone co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid results in decreased expression of ABCC3 mRNA | [34] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
hippuric acid |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
hippuric acid promotes the reaction ABCC3 protein results in increased uptake of Taurocholic Acid | [133] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Hydrocortisone |
3 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Hydrocortisone promotes the reaction ABCC3 protein affects the transport of calcein AM | [106] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
Hydrocortisone results in increased activity of ABCC3 protein | [106] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation3 |
Hydrocortisone results in increased expression of ABCC3 mRNA | [106] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
hydroquinone |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
hydroquinone results in increased expression of ABCC3 mRNA | [134] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
ICG 001 |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
ICG 001 results in increased expression of ABCC3 mRNA | [63] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
K 7174 |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
K 7174 results in increased expression of ABCC3 mRNA | [58] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Leukotriene C4 |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
verlukast inhibits the reaction ABCC3 protein results in increased transport of Leukotriene C4 | [135] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Levofloxacin |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Levofloxacin results in decreased activity of ABCC3 protein | [83] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Lithocholic Acid |
3 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Lithocholic Acid results in increased activity of ABCC3 protein | [136] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
Lithocholic Acid results in increased activity of NR1I2 protein which results in increased expression of ABCC3 mRNA | [136] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation3 |
Lithocholic Acid results in increased expression of ABCC3 mRNA | [136] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
macitentan |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
macitentan results in decreased expression of ABCC3 mRNA | [28] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
methacrylaldehyde |
3 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone results in increased expression of and results in increased oxidation of ABCC3 mRNA | [86] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
Acrolein co-treated with methacrylaldehyde co-treated with Ozone results in increased expression of ABCC3 mRNA | [87] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation3 |
Air Pollutants results in increased abundance of Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone which results in increased expression of and results in increased oxidation of ABCC3 mRNA | [86] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Methapyrilene |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Methapyrilene results in decreased expression of ABCC3 mRNA | [137] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
Methapyrilene results in increased methylation of ABCC3 intron | [88] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Methyltestosterone |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Methyltestosterone co-treated with Cholic Acids affects the expression of ABCC3 mRNA | [141] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Metyrapone |
3 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Metyrapone results in increased activity of ABCC3 protein | [136] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
Metyrapone results in increased activity of NR1I2 protein which results in increased expression of ABCC3 mRNA | [136] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation3 |
Metyrapone results in increased expression of ABCC3 mRNA | [136] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Mifepristone |
3 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Mifepristone results in increased activity of ABCC3 protein | [136] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
Mifepristone results in increased activity of NR1I2 protein which results in increased expression of ABCC3 mRNA | [136] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation3 |
Mifepristone results in increased expression of ABCC3 mRNA | [136] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
nefazodone |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
nefazodone co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid results in decreased expression of ABCC3 mRNA | [34] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
nefazodone results in decreased expression of ABCC3 mRNA | [34] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
nickel acetate |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
nickel acetate affects the expression of ABCC3 mRNA | [142] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
nickel sulfate |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
nickel sulfate results in increased expression of ABCC3 mRNA | [79] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Nifedipine |
3 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Nifedipine results in increased activity of ABCC3 protein | [136] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
Nifedipine results in increased activity of NR1I2 protein which results in increased expression of ABCC3 mRNA | [136] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation3 |
Nifedipine results in increased expression of ABCC3 mRNA | [136] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Nocodazole |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Nocodazole results in increased expression of ABCC3 mRNA | [48] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
NSC 689534 |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
NSC 689534 binds to Copper which results in increased expression of ABCC3 mRNA | [115] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
oltipraz |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
oltipraz results in increased expression of ABCC3 mRNA | [143] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Ozone |
4 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone results in increased expression of and results in increased oxidation of ABCC3 mRNA | [86] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
Acrolein co-treated with methacrylaldehyde co-treated with Ozone results in increased expression of ABCC3 mRNA | [87] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation3 |
Air Pollutants results in increased abundance of Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone which results in increased expression of and results in increased oxidation of ABCC3 mRNA | [86] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation4 |
Volatile Organic Compounds co-treated with Ozone results in increased expression of and results in increased oxidation of ABCC3 mRNA | [86] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
parthenolide |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
parthenolide inhibits the reaction Simvastatin results in increased nitrosation of ABCC3 protein | [98] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
perfluorooctane sulfonic acid |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
perfluorooctane sulfonic acid results in decreased expression of ABCC3 mRNA | [37] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
perfluorooctanoic acid |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
perfluorooctanoic acid results in increased expression of ABCC3 mRNA | [37] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Pioglitazone |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Pioglitazone results in decreased activity of ABCC3 protein | [83] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
pirarubicin |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
ABCC3 protein results in decreased susceptibility to pirarubicin | [131] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
pirinixic acid |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
pirinixic acid binds to and results in increased activity of PPARA protein which results in increased expression of ABCC3 mRNA | [145] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
potassium chromate(VI) |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
potassium chromate(VI) results in decreased expression of ABCC3 mRNA | [146] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Prednisone |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Prednisone promotes the reaction ABCC3 protein affects the transport of calcein AM | [106] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
Prednisone results in increased activity of ABCC3 protein | [106] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Pregnenolone Carbonitrile |
3 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Pregnenolone Carbonitrile results in increased activity of ABCC3 protein | [136] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
Pregnenolone Carbonitrile results in increased activity of NR1I2 protein which results in increased expression of ABCC3 mRNA | [136] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation3 |
Pregnenolone Carbonitrile results in increased expression of ABCC3 mRNA | [136] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Probenecid |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Probenecid inhibits the reaction ABCC3 protein affects the transport of estradiol-17 beta-glucuronide | [132] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
propiconazole |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
propiconazole results in decreased expression of ABCC3 mRNA | [147] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
propionaldehyde |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
propionaldehyde results in decreased expression of ABCC3 mRNA | [61] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
resveratrol-4'-O-glucuronide |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
ABCC3 protein results in increased transport of resveratrol-4'-O-glucuronide | [148] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
resveratrol-4'-O-glucuronide inhibits the reaction ABCC3 protein results in increased transport of estradiol-17 beta-glucuronide | [148] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Rifampin |
5 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Rifampin co-treated with ABCC2 gene mutant form results in increased expression of ABCC3 protein | [149] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
Rifampin inhibits the reaction Decitabine results in increased expression of ABCC3 mRNA | [9] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation3 |
Rifampin results in increased activity of ABCC3 protein | [136] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation4 |
Rifampin results in increased activity of NR1I2 protein which results in increased expression of ABCC3 mRNA | [136] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation5 |
Rifampin results in increased expression of ABCC3 mRNA | [136] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Ritonavir |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Ritonavir results in decreased activity of ABCC3 protein | [83] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
SB 203580 |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
SB 203580 inhibits the reaction Anisomycin results in increased expression of ABCC3 mRNA | [27] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
SB 203580 inhibits the reaction Clotrimazole results in increased expression of ABCC3 mRNA | [27] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
senecionine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
senecionine results in decreased expression of ABCC3 mRNA | [62] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
senkirkine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
senkirkine results in decreased expression of ABCC3 mRNA | [62] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Silicon Dioxide |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Silicon Dioxide analog results in decreased expression of ABCC3 mRNA | [150] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Silver |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Silver results in increased expression of ABCC3 mRNA | [60] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Simvastatin |
4 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
artemisinin inhibits the reaction Simvastatin results in increased nitrosation of ABCC3 protein | [98] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
parthenolide inhibits the reaction Simvastatin results in increased nitrosation of ABCC3 protein | [98] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation3 |
Simvastatin promotes the reaction Doxorubicin results in increased nitrosation of ABCC3 protein | [98] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation4 |
Simvastatin results in increased nitrosation of ABCC3 protein | [98] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
S-nitrosopenicillamine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
S-nitrosopenicillamine results in increased metabolism of ABCC3 protein | [125] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
sodium arsenate |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
sodium arsenate results in increased abundance of Arsenic which results in increased expression of ABCC3 mRNA | [96] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
sodium arsenite |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
sodium arsenite results in increased expression of ABCC3 mRNA | [59] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
sodium bichromate |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
sodium bichromate results in decreased expression of ABCC3 mRNA | [53] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Sodium Dodecyl Sulfate |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Sodium Dodecyl Sulfate results in increased expression of ABCC3 mRNA | [151] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Sodium Selenite |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Sodium Selenite results in increased expression of ABCC3 mRNA | [152] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Sorafenib |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
ABCC3 affects the susceptibility to Sorafenib | [153] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
sulforaphane |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
sulforaphane results in increased expression of ABCC3 mRNA | [68] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Tartrazine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Tartrazine results in decreased expression of ABCC3 mRNA | [85] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Tetrachlorodibenzodioxin |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Estradiol co-treated with Tetrachlorodibenzodioxin results in increased expression of ABCC3 mRNA | [128] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
Tetrachlorodibenzodioxin results in increased expression of ABCC3 mRNA | [128] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Theophylline |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Theophylline results in decreased activity of ABCC3 protein | [83] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Thiram |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Thiram results in decreased expression of ABCC3 mRNA | [116] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Ticlopidine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Ticlopidine results in decreased activity of ABCC3 protein | [83] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
trichostatin A |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
trichostatin A results in decreased expression of ABCC3 mRNA | [48] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
triphenyl phosphate |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
triphenyl phosphate affects the expression of ABCC3 mRNA | [123] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
tris(2-butoxyethyl) phosphate |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
tris(2-butoxyethyl) phosphate affects the expression of ABCC3 mRNA | [156] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Verapamil |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Verapamil inhibits the reaction ABCC3 protein affects the export of 5-carboxyfluorescein diacetate | [81] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
verlukast |
3 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
verlukast inhibits the reaction ABCC3 protein results in increased transport of calcein AM | [107] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
verlukast inhibits the reaction ABCC3 protein results in increased transport of Leukotriene C4 | [135] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation3 |
verlukast inhibits the reaction ABCC3 protein results in increased transport of zearalenol | [107] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Vincristine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Vincristine results in decreased susceptibility to Vincristine which results in increased expression of ABCC3 mRNA | [124] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Vitamin K 3 |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Vitamin K 3 affects the expression of ABCC3 mRNA | [17] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
zafirlukast |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
zafirlukast results in decreased activity of ABCC3 protein | [83] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
zearalenol |
3 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
ABCC3 protein results in increased transport of zearalenol | [107] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
verlukast inhibits the reaction ABCC3 protein results in increased transport of zearalenol | [107] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation3 |
zearalenol inhibits the reaction ABCC3 protein results in increased transport of calcein AM | [107] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Fungicide |
|||||
tebuconazole |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
tebuconazole results in decreased expression of ABCC3 mRNA | [147] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Approved Drug |
|||||
Delavirdine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Delavirdine inhibits the transportation of 5-Chloromethylfluorescein diacetate by ABCC3 | [2] | |||
Affected Drug/Substrate |
5-Chloromethylfluorescein diacetate | Modulation Type | Inhibition | ||
Cell System |
Madin Darby canine kidney strain II (MDCKII) cells-MRP3 | ||||
Efavirenz |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Efavirenz inhibits the transportation of 5-Chloromethylfluorescein diacetate by ABCC3 | [2] | |||
Affected Drug/Substrate |
5-Chloromethylfluorescein diacetate | Modulation Type | Inhibition | ||
Cell System |
Madin Darby canine kidney strain II (MDCKII) cells-MRP3 | ||||
Emtricitabine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Emtricitabine inhibits the transportation of 5-Chloromethylfluorescein diacetate by ABCC3 | [2] | |||
Affected Drug/Substrate |
5-Chloromethylfluorescein diacetate | Modulation Type | Inhibition | ||
Cell System |
Madin Darby canine kidney strain II (MDCKII) cells-MRP3 | ||||
Cefaclor |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Cefaclor inhibits the transportation of Estradiol-17beta-glucuronide by ABCC3 | [3] | |||
Affected Drug/Substrate |
Estradiol-17beta-glucuronide | Modulation Type | Inhibition | ||
Cell System |
Spodoptera frugiperda 21-MRP3 | ||||
Cefadroxil |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Cefadroxil inhibits the transportation of Estradiol-17beta-glucuronide by ABCC3 | [3] | |||
Affected Drug/Substrate |
Estradiol-17beta-glucuronide | Modulation Type | Inhibition | ||
Cell System |
Spodoptera frugiperda 21-MRP3 | ||||
Cefamandole |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Cefamandole inhibits the transportation of Estradiol-17beta-glucuronide by ABCC3 | [3] | |||
Affected Drug/Substrate |
Estradiol-17beta-glucuronide | Modulation Type | Inhibition | ||
Cell System |
Spodoptera frugiperda 21-MRP3 | ||||
Cefmetazole |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Cefmetazole inhibits the transportation of Estradiol-17beta-glucuronide by ABCC3 | [3] | |||
Affected Drug/Substrate |
Estradiol-17beta-glucuronide | Modulation Type | Inhibition | ||
Cell System |
Spodoptera frugiperda 21-MRP3 | ||||
Cefoperazone |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Cefoperazone inhibits the transportation of Estradiol-17beta-glucuronide by ABCC3 | [3] | |||
Affected Drug/Substrate |
Estradiol-17beta-glucuronide | Modulation Type | Inhibition | ||
Cell System |
Spodoptera frugiperda 21-MRP3 | ||||
Cefoxitin |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Cefoxitin inhibits the transportation of Estradiol-17beta-glucuronide by ABCC3 | [3] | |||
Affected Drug/Substrate |
Estradiol-17beta-glucuronide | Modulation Type | Inhibition | ||
Cell System |
Spodoptera frugiperda 21-MRP3 | ||||
Ceftriaxone |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Ceftriaxone inhibits the transportation of Estradiol-17beta-glucuronide by ABCC3 | [3] | |||
Affected Drug/Substrate |
Estradiol-17beta-glucuronide | Modulation Type | Inhibition | ||
Cell System |
Spodoptera frugiperda 21-MRP3 | ||||
Cefuroxime |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Cefuroxime inhibits the transportation of Estradiol-17beta-glucuronide by ABCC3 | [3] | |||
Affected Drug/Substrate |
Estradiol-17beta-glucuronide | Modulation Type | Inhibition | ||
Cell System |
Spodoptera frugiperda 21-MRP3 | ||||
Cephalexin |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Cephalexin inhibits the transportation of Estradiol-17beta-glucuronide by ABCC3 | [3] | |||
Affected Drug/Substrate |
Estradiol-17beta-glucuronide | Modulation Type | Inhibition | ||
Cell System |
Spodoptera frugiperda 21-MRP3 | ||||
Cephradine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Cephradine inhibits the transportation of Estradiol-17beta-glucuronide by ABCC3 | [3] | |||
Affected Drug/Substrate |
Estradiol-17beta-glucuronide | Modulation Type | Inhibition | ||
Cell System |
Spodoptera frugiperda 21-MRP3 | ||||
Doxorubicin |
4 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Doxorubicin inhibits the activity of ABCC3 | [5] | |||
Cell System |
Human colon cancer cells (HT-29)-MRP3 | ||||
Hydroquinone |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Hydroquinone increases the expression of ABCC3 | [6] | |||
Regulation Mechanism |
via enhancement of Nuclear factor erythroid 2-related factor 2 (NFE2L2) | Transcription Factor Info | |||
Cell System |
C57BL/6J and 129S6/SvJ hybrid mice | ||||
Cholic Acid |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Cholic Acid increases the expression of ABCC3 | [7] | |||
Regulation Mechanism |
via enhancement of Nuclear receptor subfamily 1 group I member 2 (NR1I2) | Transcription Factor Info | |||
Cell System |
C57BL/6 mice | ||||
Ursodeoxycholic Acid |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Ursodeoxycholic Acid increases the expression of ABCC3 | [8] | |||
Regulation Mechanism |
via enhancement of Nuclear factor erythroid 2-related factor 2 (NFE2L2) | Transcription Factor Info | |||
Cell System |
C57/B6 mice | ||||
Decitabine |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Decitabine increases the expression of ABCC3 | [9] | |||
Regulation Mechanism |
via enhancement of Nuclear receptor subfamily 1 group I member 2 (NR1I2) | Transcription Factor Info | |||
Cell System |
Human head and neck squamous cell carcinoma isolates | ||||
Fulvestrant |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Fulvestrant increases the expression of ABCC3 | [10] | |||
Regulation Mechanism |
via modulation of Estrogen receptor (ESR1) | Transcription Factor Info | |||
Cell System |
Human breast carcinoma cells (MCF-7) | ||||
Estradiol |
6 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Estradiol increases the expression of ABCC3 | [11] | |||
Regulation Mechanism |
via the inhibition of Nuclear receptor subfamily 1 group I member 2 | Transcription Factor Info | |||
Cell System |
human liver parenchymal cells (LO2) | ||||
Indomethacin |
6 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Indomethacin increases the expression of ABCC3 | [12] | |||
Sulindac |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Sulindac increases the expression of ABCC3 | [12] | |||
Calcitriol |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Calcitriol increases the expression of ABCC3 | [13] | |||
Chlorpromazine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Chlorpromazine increases the expression of ABCC3 | [14] | |||
Tretinoin |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Tretinoin increases the expression of ABCC3 | [15] | |||
Diethylstilbestrol |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Diethylstilbestrol inhibits the expression of ABCC3 | [16] | |||
Hydrogen Peroxide |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Hydrogen Peroxide affects the expression of ABCC3 | [17] | |||
Menadione |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Menadione affects the expression of ABCC3 | [17] | |||
Dasatinib |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Dasatinib increases the expression of ABCC3 | [18] | |||
Cisplatin |
3 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Cisplatin increases the expression of ABCC3 | [19] | |||
Paclitaxel |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Paclitaxel increases the expression of ABCC3 | [19] | |||
Ampicillin |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Ampicillin inhibits the expression of ABCC3 | [20] | |||
Progesterone |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Progesterone increases the expression of ABCC3 | [21] | |||
Arsenic Trioxide |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Arsenic Trioxide inhibits the expression of ABCC3 | [22] | |||
Isoproterenol |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Isoproterenol inhibits the expression of ABCC3 | [23] | |||
Zidovudine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Zidovudine increases the expression of ABCC3 | [24] | |||
Tolvaptan |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Tolvaptan inhibits the activity of ABCC3 | [26] | |||
Clotrimazole |
3 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Clotrimazole increases the expression of ABCC3 | [27] | |||
Bosentan |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Bosentan inhibits the expression of ABCC3 | [28] | |||
Macitentan |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Macitentan inhibits the expression of ABCC3 | [28] | |||
Urethane |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Urethane inhibits the expression of ABCC3 | [29] | |||
Valproic Acid |
5 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Valproic Acid inhibits the expression of ABCC3 | [30] | |||
Calcipotriene |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Calcipotriene increases the expression of ABCC3 | [31] | |||
Methoxsalen |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Methoxsalen increases the expression of ABCC3 | [31] | |||
Cannabidiol |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Cannabidiol increases the expression of ABCC3 | [32] | |||
Temozolomide |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Temozolomide increases the expression of ABCC3 | [33] | |||
Nefazodone |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Nefazodone inhibits the expression of ABCC3 | [34] | |||
Meclizine |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Meclizine increases the expression of ABCC3 | [35] | |||
Copper Sulfate |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Copper Sulfate increases the expression of ABCC3 | [36] | |||
Troglitazone |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Troglitazone increases the expression of ABCC3 | [27] | |||
Cyclosporine |
5 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Cyclosporine inhibits the expression of ABCC3 | [37] | |||
Methotrexate |
4 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Methotrexate inhibits the activity of ABCC3 | [38], [39] | |||
Etoposide |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Etoposide inhibits the activity of ABCC3 | [38], [40] | |||
Acetaminophen |
4 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Acetaminophen induces the activity of ABCC3 | [41] | |||
DT Modulation2 |
Acetaminophen results in decreased activity of ABCC3 protein | [83] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation3 |
Acetaminophen results in decreased expression of ABCC3 mRNA | [84] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation4 |
Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Acetaminophen results in decreased expression of ABCC3 mRNA | [85] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Phenobarbital |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Phenobarbital induces the activity of ABCC3 | [42], [43] | |||
Chenodeoxycholic acid |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Chenodeoxycholic acid induces the activity of ABCC3 | [44] | |||
Prasterone |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Prasterone induces the activity of ABCC3 | [45] | |||
Micafungin |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Micafungin inhibits the activity of ABCC3 | [46] | |||
Drug Marketed but not Approved by US FDA |
|||||
Clodronic Acid |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Clodronic Acid increases the expression of ABCC3 | [25] | |||
Drug in Phase 3 Trial |
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Oltipraz |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Oltipraz increases the expression of ABCC3 | [6] | |||
Regulation Mechanism |
via enhancement of Nuclear factor erythroid 2-related factor 2 (NFE2L2) | Transcription Factor Info | |||
Cell System |
C57BL/6J and 129S6/SvJ hybrid mice | ||||
Afimoxifene |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Afimoxifene increases the expression of ABCC3 | [49] | |||
Resveratrol |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Resveratrol increases the expression of ABCC3 | [54] | |||
Triclosan |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Triclosan increases the expression of ABCC3 | [67] | |||
Sulforafan |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Sulforafan increases the expression of ABCC3 | [68] | |||
Drug in Phase 2 Trial |
|||||
Taurocholic Acid |
5 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Taurocholic Acid increases the activity of ABCC3 | [52] | |||
Genistein |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Genistein inhibits the expression of ABCC3 | [16] | |||
Ethanol |
3 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Ethanol increases the expression of ABCC3 | [35] | |||
Bisphenol A |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Bisphenol A increases the expression of ABCC3 | [72] | |||
Drug in Phase 1/2 Trial |
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Sodium taurocholate |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Sodium taurocholate inhibits the transportation of Estradiol-17beta-glucuronide by ABCC3 (IC50 = 40 microM) | [1] | |||
Affected Drug/Substrate |
Estradiol-17beta-glucuronide | Modulation Type | Inhibition | ||
Cell System |
Human embryonic kidney 293 cells (HEK293)-MRP3 | ||||
Drug in Phase 1 Trial |
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Trichostatin A |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Trichostatin A inhibits the expression of ABCC3 | [48] | |||
Dihydrotestosterone |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Dihydrotestosterone increases the expression of ABCC3 | [50] | |||
Sodium arsenite |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Sodium arsenite increases the expression of ABCC3 | [59] | |||
TAK-875 |
4 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
TAK-875 inhibits the activity of ABCC3 | [66] | |||
Drug in Preclinical Test |
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Oxypertine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Oxypertine induces the activity of ABCC3 | [74] | |||
Patented Pharmaceutical Agent |
|||||
HSDB-595 |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
HSDB-595 increases the expression of ABCC3 | [57] | |||
K-7174 |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
K-7174 increases the expression of ABCC3 | [58] | |||
ICG-001 |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
ICG-001 increases the expression of ABCC3 | [63] | |||
Drug Withdrawn |
|||||
Rimonabant |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Rimonabant inhibits the transportation of Estradiol 17b-D-glucuronide by ABCC3 | [4] | |||
Affected Drug/Substrate |
Estradiol 17b-D-glucuronide | Modulation Type | Inhibition | ||
Cell System |
Human embryonic kidney 293 cells (HEK293)-MRP3 | ||||
Natural Product |
|||||
DT Modulation1 |
Resveratrol metabolite promotes the reaction ABCC3 protein results in increased transport of estradiol-17 beta-glucuronide | [148] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Cinnamic aldehyde |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Cinnamic aldehyde increases the expression of ABCC3 | [55] | |||
Senecionine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Senecionine inhibits the expression of ABCC3 | [62] | |||
Tobacco Smoke Pollution |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Tobacco Smoke Pollution inhibits the expression of ABCC3 | [65] | |||
Particulate Matter |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Particulate Matter increases the expression of ABCC3 | [73] | |||
Environmental toxicant |
|||||
Polychlorinated dibenzodioxin |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Polychlorinated dibenzodioxin increases the expression of ABCC3 | [47] | |||
Regulation Mechanism |
via enhancement of Aryl hydrocarbon receptor (AHR) | Transcription Factor Info | |||
Cell System |
Human gastric signet ring cell adenocarcinoma cells (SNU-601) | ||||
Mycotoxins |
|||||
Deoxynivalenol |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Deoxynivalenol inhibits the expression of ABCC3 | [69] | |||
Aflatoxin B1 |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Aflatoxin B1 results in decreased methylation of ABCC3 exon | [88] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
Aflatoxin B1 results in decreased methylation of ABCC3 gene | [89] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
aflatoxin B2 |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
aflatoxin B2 results in increased methylation of ABCC3 intron | [88] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Zearalenone |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Zearalenone inhibits the reaction ABCC3 protein results in increased transport of calcein AM | [107] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
Zearalenone results in decreased expression of ABCC3 mRNA | [16] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Acute Toxic Substance |
|||||
Cycloheximide |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Cycloheximide increases the expression of ABCC3 | [49] | |||
Anisomycin |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Anisomycin increases the expression of ABCC3 | [27] | |||
Formaldehyde |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Formaldehyde increases the expression of ABCC3 | [64] | |||
Okadaic Acid |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Okadaic Acid inhibits the expression of ABCC3 | [70] | |||
Carcinogen |
|||||
2-acetylaminofluorene |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
2-acetylaminofluorene increases the expression of ABCC3 | [48] | |||
Dimethyl nitrosamine |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Dimethyl nitrosamine increases the expression of ABCC3 | [51] | |||
Sodium bichromate |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Sodium bichromate inhibits the expression of ABCC3 | [53] | |||
Benzo(a)pyrene |
3 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Benzo(a)pyrene increases the expression of ABCC3 | [71] | |||
Arsenic |
2 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Arsenic results in increased expression of ABCC3 mRNA | [95] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
DT Modulation2 |
sodium arsenate results in increased abundance of Arsenic which results in increased expression of ABCC3 mRNA | [96] | |||
Regulation Mechanism |
Transcription Factor Info | ||||
Health and Environmental Toxicant |
|||||
Lead |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Lead increases the expression of ABCC3 | [56] | |||
Butyraldehyde |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Butyraldehyde inhibits the expression of ABCC3 | [61] | |||
Perfluorooctane sulfonic acid |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Perfluorooctane sulfonic acid inhibits the expression of ABCC3 | [37] | |||
Nanoparticle |
|||||
Silver nanoparticle |
1 DT Activity Modulations Related to This Exogenous Factor | Click to Show/Hide the Full List | |||
DT Modulation1 |
Silver nanoparticle increases the expression of ABCC3 | [60] | |||
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