Detail Information of Exogenous Modulation

General Information of Drug Transporter (DT)
DT ID	DTD0009 Transporter Info
Gene Name	SLC22A3
Transporter Name	Organic cation transporter 3
Gene ID	6581
UniProt ID	O75751

Exogenous factors (drugs, dietary constituents, etc.) Modulation of This DT (EGM)
Approved Drug
Quinine	6 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Quinine inhibits the transportation of N-methylpyridinium by SLC22A3 (IC50 = 18.3 microM)			[1]
Affected Drug/Substrate	N-methylpyridinium	Modulation Type	Inhibition
Cell System	Oocytes-OCT3
DT Modulation2	Quinine inhibits the transportation of N-methylpyridinium by SLC22A3 (IC50 = 37 microM)			[2]
Affected Drug/Substrate	N-methylpyridinium	Modulation Type	Inhibition
Cell System	Chinese hamster ovary (CHO) cells-OCT3
DT Modulation3	Quinine inhibits the transportation of N-methylpyridinium by SLC22A3 (IC50 = 22.7 microM)			[3]
Affected Drug/Substrate	N-methylpyridinium	Modulation Type	Inhibition
Cell System	Chinese hamster ovary (CHO) cells-OCT3
DT Modulation4	Quinine inhibits the activity of SLC22A3			[4]
Clonidine	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Clonidine inhibits the transportation of N-methylpyridinium by SLC22A3 (Ki = 373 microM)			[5]
Affected Drug/Substrate	N-methylpyridinium	Modulation Type	Inhibition
Cell System	Human retinal pigment epithelial (HRPE) cells-OCT3
DT Modulation2	Clonidine inhibits the transportation of N-methylpyridinium by SLC22A3 (IC50 = 110 microM)			[2]
Affected Drug/Substrate	N-methylpyridinium	Modulation Type	Inhibition
Cell System	Chinese hamster ovary (CHO) cells-OCT3
Desipramine	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Desipramine inhibits the transportation of N-methylpyridinium by SLC22A3 (Ki = 14 microM)			[5]
Affected Drug/Substrate	N-methylpyridinium	Modulation Type	Inhibition
Cell System	Human retinal pigment epithelial (HRPE) cells-OCT3
DT Modulation2	Desipramine inhibits the activity of SLC22A3			[7]
Metformin	8 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Metformin inhibits the transportation of N-methylpyridinium by SLC22A3 (IC50 = 2332 microM)			[1]
Affected Drug/Substrate	N-methylpyridinium	Modulation Type	Inhibition
Cell System	Oocytes-OCT3
DT Modulation2	Metformin inhibits the transportation of N-methylpyridinium by SLC22A3 (Ki = 904 microM)			[6]
Affected Drug/Substrate	N-methylpyridinium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OCT3
DT Modulation3	Carvedilol inhibits the reaction SLC22A3 protein results in increased uptake of Metformin			[38]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Cimetidine inhibits the reaction SLC22A3 protein results in increased uptake of Metformin			[38]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Imipramine inhibits the reaction SLC22A3 protein results in increased uptake of Metformin			[38]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Metformin inhibits the reaction SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	SLC22A3 protein results in increased uptake of Metformin			[38]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	Verapamil inhibits the reaction SLC22A3 protein results in increased uptake of Metformin			[38]
Regulation Mechanism				Transcription Factor Info
Ranitidine	5 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ranitidine inhibits the transportation of N-methylpyridinium by SLC22A3 (IC50 = 290 microM)			[1]
Affected Drug/Substrate	N-methylpyridinium	Modulation Type	Inhibition
Cell System	Oocytes-OCT3
DT Modulation2	Ranitidine inhibits the transportation of N-methylpyridinium by SLC22A3 (IC50 = 372 microM)			[2]
Affected Drug/Substrate	N-methylpyridinium	Modulation Type	Inhibition
Cell System	Chinese hamster ovary (CHO) cells-OCT3
Estradiol	6 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Estradiol inhibits the transportation of 1-Methyl-4-phenylpyridinium by SLC22A3 (IC50 = 2.88 microM)			[8]
Affected Drug/Substrate	1-Methyl-4-phenylpyridinium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OCT3
Phenoxybenzamine	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Phenoxybenzamine inhibits the transportation of 1-Methyl-4-phenylpyridinium by SLC22A3 (IC50 = 6.13 microM)			[8]
Affected Drug/Substrate	1-Methyl-4-phenylpyridinium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OCT3
Progesterone	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Progesterone inhibits the transportation of 1-Methyl-4-phenylpyridinium by SLC22A3 (IC50 = 4.28 microM)			[8]
Affected Drug/Substrate	1-Methyl-4-phenylpyridinium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OCT3
Ergotidine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ergotidine inhibits the transportation of N-methylpyridinium by SLC22A3 (Ki = 140 microM)			[9]
Affected Drug/Substrate	N-methylpyridinium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OCT3
Imipramine	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Imipramine inhibits the transportation of N-methylpyridinium by SLC22A3 (Ki = 42 microM)			[5]
Affected Drug/Substrate	N-methylpyridinium	Modulation Type	Inhibition
Cell System	Human retinal pigment epithelial (HRPE) cells-OCT3
Procainamide	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Procainamide inhibits the transportation of N-methylpyridinium by SLC22A3 (Ki = 738 microM)			[5]
Affected Drug/Substrate	N-methylpyridinium	Modulation Type	Inhibition
Cell System	Human retinal pigment epithelial (HRPE) cells-OCT3
Famotidine	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Famotidine inhibits the transportation of N-methylpyridinium by SLC22A3 (IC50 = 6.7 microM)			[1]
Affected Drug/Substrate	N-methylpyridinium	Modulation Type	Inhibition
Cell System	Oocytes-OCT3
Atropine	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Atropine inhibits the transportation of N-methylpyridinium by SLC22A3 (IC50 = 466 microM)			[2]
Affected Drug/Substrate	N-methylpyridinium	Modulation Type	Inhibition
Cell System	Chinese hamster ovary (CHO) cells-OCT3
Diphenhydramine	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Diphenhydramine inhibits the transportation of N-methylpyridinium by SLC22A3 (IC50 = 695 microM)			[2]
Affected Drug/Substrate	N-methylpyridinium	Modulation Type	Inhibition
Cell System	Chinese hamster ovary (CHO) cells-OCT3
Amantadine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Amantadine inhibits the transportation of N-methylpyridinium by SLC22A3 (Ki > 1000 microM)			[10]
Affected Drug/Substrate	N-methylpyridinium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OCT3
Cocaine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cocaine inhibits the transportation of N-methylpyridinium by SLC22A3 (Ki > 1000 microM)			[10]
Affected Drug/Substrate	N-methylpyridinium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OCT3
Dextroamphetamine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Dextroamphetamine inhibits the transportation of N-methylpyridinium by SLC22A3 (Ki = 460 microM)			[10]
Affected Drug/Substrate	N-methylpyridinium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OCT3
Ketamine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ketamine inhibits the transportation of N-methylpyridinium by SLC22A3 (Ki = 225.7 microM)			[10]
Affected Drug/Substrate	N-methylpyridinium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OCT3
Memantine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Memantine inhibits the transportation of N-methylpyridinium by SLC22A3 (Ki = 236 microM)			[10]
Affected Drug/Substrate	N-methylpyridinium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OCT3
Pentamidine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Pentamidine inhibits the transportation of N-methylpyridinium by SLC22A3 (IC50 = 14.8 microM)			[3]
Affected Drug/Substrate	N-methylpyridinium	Modulation Type	Inhibition
Cell System	Chinese hamster ovary (CHO) cells-OCT3
Prazosin	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Prazosin inhibits the transportation of N-methylpyridinium by SLC22A3 (IC50 = 12.6 microM)			[8]
Affected Drug/Substrate	N-methylpyridinium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OCT3
Mifepristone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Mifepristone inhibits the expression of SLC22A3			[12]
Phenobarbital	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Phenobarbital affects the expression of SLC22A3			[13]
Copper Sulfate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Copper Sulfate inhibits the expression of SLC22A3			[14]
Cisplatin	5 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cisplatin inhibits the expression of SLC22A3			[15]
Acetaminophen	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Acetaminophen inhibits the expression of SLC22A3			[16]
Decitabine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Decitabine affects the expression of SLC22A3			[17]
Hydrogen Peroxide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Hydrogen Peroxide affects the expression of SLC22A3			[18]
Menadione	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Menadione affects the expression of SLC22A3			[18]
Valproic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Valproic Acid affects the expression of SLC22A3			[19]
Mdv-3100	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Mdv-3100 inhibits the expression of SLC22A3			[20]
Doxorubicin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Doxorubicin affects the expression of SLC22A3			[21]
Cyclosporine	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cyclosporine inhibits the expression of SLC22A3			[22]
Atorvastatin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Atorvastatin inhibits the reaction SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[37]
Regulation Mechanism				Transcription Factor Info
Drug in Phase 3 Trial
Corticosterone	5 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Corticosterone inhibits the activity of SLC22A3			[8]
Triclosan	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Triclosan inhibits the expression of SLC22A3			[28]
Drug in Phase 2 Trial
YM155	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	YM155 inhibits the transportation of N-methylpyridinium by SLC22A3 (IC50 = 108 microM)			[11]
Affected Drug/Substrate	N-methylpyridinium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OCT3
MeIQx	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	MeIQx inhibits the activity of SLC22A3			[27]
Drug in Phase 1 Trial
Quercetin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Quercetin inhibits the expression of SLC22A3			[23]
Sodium arsenite	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sodium arsenite inhibits the expression of SLC22A3			[30]
Drug in Preclinical Test
Beta-carboline	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Beta-carboline inhibits the activity of SLC22A3			[27]
Discontinued Drug
Dizocilpine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Dizocilpine inhibits the transportation of N-methylpyridinium by SLC22A3 (Ki = 224 microM)			[10]
Affected Drug/Substrate	N-methylpyridinium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OCT3
Antiparasitics	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Antiparasitics inhibits the transportation of N-methylpyridinium by SLC22A3 (IC50 = 20.4 microM)			[3]
Affected Drug/Substrate	N-methylpyridinium	Modulation Type	Inhibition
Cell System	Chinese hamster ovary (CHO) cells-OCT3
Investigative Drug
Tetraethylammonium	7 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tetraethylammonium inhibits the transportation of N-methylpyridinium by SLC22A3 (Ki = 1372 microM)			[5]
Affected Drug/Substrate	N-methylpyridinium	Modulation Type	Inhibition
Cell System	Human retinal pigment epithelial (HRPE) cells-OCT3
DT Modulation2	Tetraethylammonium inhibits the transportation of N-methylpyridinium by SLC22A3 (IC50 = 1237 microM)			[1]
Affected Drug/Substrate	N-methylpyridinium	Modulation Type	Inhibition
Cell System	Oocytes-OCT3
DT Modulation3	Tetraethylammonium inhibits the transportation of N-methylpyridinium by SLC22A3 (IC50 = 1476.6 microM)			[3]
Affected Drug/Substrate	N-methylpyridinium	Modulation Type	Inhibition
Cell System	Chinese hamster ovary (CHO) cells-OCT3
Phencyclidine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Phencyclidine inhibits the transportation of N-methylpyridinium by SLC22A3 (Ki = 333 microM)			[10]
Affected Drug/Substrate	N-methylpyridinium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OCT3
Drug Withdrawn
Etilefrine	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Etilefrine inhibits the transportation of N-methylpyridinium by SLC22A3 (IC50 = 4448 microM)			[2]
Affected Drug/Substrate	N-methylpyridinium	Modulation Type	Inhibition
Cell System	Chinese hamster ovary (CHO) cells-OCT3
Phenformin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Phenformin inhibits the transportation of N-methylpyridinium by SLC22A3 (Ki = 134 microM)			[6]
Affected Drug/Substrate	N-methylpyridinium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OCT3
Natural Product
Tobacco Smoke Pollution	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tobacco Smoke Pollution inhibits the expression of SLC22A3			[29]
Particulate Matter	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Particulate Matter inhibits the expression of SLC22A3			[34]
Environmental toxicant
Polychlorinated dibenzodioxin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Polychlorinated dibenzodioxin inhibits the expression of SLC22A3			[32]
Mycotoxins
Aflatoxin B1	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Aflatoxin B1 inhibits the expression of SLC22A3			[33]
DT Modulation2	Aflatoxin B1 affects the expression of SLC22A3 protein			[40]
Regulation Mechanism				Transcription Factor Info
Zearalenone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Zearalenone results in increased expression of SLC22A3 mRNA			[46]
Regulation Mechanism				Transcription Factor Info
Acute Toxic Substance
Oxyquinoline	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Oxyquinoline inhibits the expression of SLC22A3			[23]
Formaldehyde	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Formaldehyde increases the expression of SLC22A3			[24]
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine inhibits the activity of SLC22A3			[27]
Carcinogen
2-amino-3-methylimidazo(4,5-f)quinoline	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	2-amino-3-methylimidazo(4,5-f)quinoline inhibits the activity of SLC22A3			[27]
Benzo(a)pyrene	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Benzo(a)pyrene inhibits the expression of SLC22A3			[31]
Cadmium	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cadmium Chloride results in increased abundance of Cadmium which results in increased expression of SLC22A3 mRNA			[48]
Regulation Mechanism				Transcription Factor Info
Health and Environmental Toxicant
Butyraldehyde	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Butyraldehyde inhibits the expression of SLC22A3			[25]
tris(1,3-dichloro-2-propyl)phosphate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	tris(1,3-dichloro-2-propyl)phosphate inhibits the expression of SLC22A3			[26]
Endosulfan	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Endosulfan inhibits the reaction Tetrachlorodibenzodioxin results in decreased expression of SLC22A3 mRNA			[32]
Regulation Mechanism				Transcription Factor Info
Chemical Compound
DT Modulation1	Quinine inhibits the reaction SLC22A3 protein results in increased transport of 1-Methyl-4-phenylpyridinium			[2]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Quinine inhibits the reaction SLC22A3 protein results in increased uptake of Ethidium			[35]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	SLC22A3 protein results in increased uptake of Tetraethylammonium			[5]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Tetraethylammonium inhibits the reaction SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Tetraethylammonium inhibits the reaction SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium analog			[5]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Tetraethylammonium inhibits the reaction SLC22A3 protein results in increased uptake of Ethidium			[35]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Clonidine inhibits the reaction SLC22A3 protein results in increased transport of 1-Methyl-4-phenylpyridinium			[2]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Clonidine inhibits the reaction SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium analog			[5]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Desipramine inhibits the reaction SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium analog			[5]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Ranitidine inhibits the reaction SLC22A3 protein affects the transport of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Ranitidine inhibits the reaction SLC22A3 protein results in increased transport of 1-Methyl-4-phenylpyridinium			[2]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Ranitidine inhibits the reaction SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Estradiol co-treated with TGFB1 protein results in increased expression of SLC22A3 mRNA			[56]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Estradiol inhibits the reaction SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[8]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Estradiol results in decreased activity of SLC22A3 protein			[8]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Estradiol results in decreased expression of SLC22A3 mRNA			[40]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Estradiol results in increased expression of SLC22A3 mRNA			[46]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Phenoxybenzamine inhibits the reaction SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[8]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Phenoxybenzamine results in decreased activity of SLC22A3 protein			[8]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Progesterone inhibits the reaction SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[8]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Progesterone results in decreased activity of SLC22A3 protein			[8]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Imipramine inhibits the reaction SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[38]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Imipramine inhibits the reaction SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium analog			[5]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Imipramine inhibits the reaction SLC22A3 protein results in increased uptake of Metformin			[38]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Procainamide inhibits the reaction SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium analog			[5]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Famotidine inhibits the reaction SLC22A3 protein affects the transport of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Famotidine inhibits the reaction SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Famotidine results in decreased activity of SLC22A3 protein			[1]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Atropine inhibits the reaction SLC22A3 protein results in increased transport of 1-Methyl-4-phenylpyridinium			[2]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	SLC22A3 protein results in increased uptake of Atropine			[2]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Diphenhydramine inhibits the reaction SLC22A3 protein results in increased transport of 1-Methyl-4-phenylpyridinium			[2]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Etilefrine inhibits the reaction SLC22A3 protein results in increased transport of 1-Methyl-4-phenylpyridinium			[2]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	SLC22A3 protein results in increased uptake of Etilefrine			[2]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Prazosin inhibits the reaction SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[8]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Prazosin results in decreased activity of SLC22A3 protein			[8]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Cisplatin affects the expression of SLC22A3 mRNA			[17]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Cisplatin co-treated with jinfukang results in decreased expression of SLC22A3 mRNA			[52]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	SLC22A3 affects the susceptibility to Cisplatin			[15]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	SLC22A3 results in increased uptake of Cisplatin			[15]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Cyclosporine results in increased expression of SLC22A3 mRNA			[54]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Corticosterone inhibits the reaction SLC22A3 protein results in increased import of 4-(4-(dimethylamino)styryl)-1-methylpyridinium iodide			[27]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Corticosterone inhibits the reaction SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[8]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Corticosterone inhibits the reaction SLC22A3 protein results in increased uptake of Formoterol Fumarate			[47]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Corticosterone results in decreased activity of SLC22A3 protein			[8]
Regulation Mechanism				Transcription Factor Info
Pentanal	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Pentanal inhibits the expression of SLC22A3			[25]
DT Modulation1	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine inhibits the reaction SLC22A3 protein results in increased import of 4-(4-(dimethylamino)styryl)-1-methylpyridinium iodide			[27]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased activity of SLC22A3 protein			[27]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Benzo(a)pyrene co-treated with benzo(b)fluoranthene affects the expression of SLC22A3 mRNA			[43]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Benzo(a)pyrene results in increased methylation of SLC22A3 exon			[44]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Benzo(a)pyrene results in increased methylation of SLC22A3 promoter			[44]
Regulation Mechanism				Transcription Factor Info
1-Methyl-4-phenylpyridinium	55 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	1-Methyl-4-phenylpyridinium analog inhibits the reaction SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium analog			[5]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	1-Methyl-4-phenylpyridinium inhibits the reaction SLC22A3 protein results in increased uptake of Ethidium			[35]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	4-(1H-imidazol-4-ylmethyl)piperidine inhibits the reaction SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[36]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Atorvastatin inhibits the reaction SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[37]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Atropine inhibits the reaction SLC22A3 protein results in increased transport of 1-Methyl-4-phenylpyridinium			[2]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	BU 224 inhibits the reaction SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[36]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	Carvedilol inhibits the reaction SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[37]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	Cimetidine inhibits the reaction SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[38]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	clobenpropit inhibits the reaction SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[36]
Regulation Mechanism				Transcription Factor Info
DT Modulation10	Clonidine inhibits the reaction SLC22A3 protein results in increased transport of 1-Methyl-4-phenylpyridinium			[2]
Regulation Mechanism				Transcription Factor Info
DT Modulation11	Clonidine inhibits the reaction SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium analog			[5]
Regulation Mechanism				Transcription Factor Info
DT Modulation12	Corticosterone inhibits the reaction SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[8]
Regulation Mechanism				Transcription Factor Info
DT Modulation13	Desipramine inhibits the reaction SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium analog			[5]
Regulation Mechanism				Transcription Factor Info
DT Modulation14	Digoxin inhibits the reaction SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[37]
Regulation Mechanism				Transcription Factor Info
DT Modulation15	Diphenhydramine inhibits the reaction SLC22A3 protein results in increased transport of 1-Methyl-4-phenylpyridinium			[2]
Regulation Mechanism				Transcription Factor Info
DT Modulation16	disprocynium 24 inhibits the reaction SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[36]
Regulation Mechanism				Transcription Factor Info
DT Modulation17	Estradiol inhibits the reaction SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[8]
Regulation Mechanism				Transcription Factor Info
DT Modulation18	Etilefrine inhibits the reaction SLC22A3 protein results in increased transport of 1-Methyl-4-phenylpyridinium			[2]
Regulation Mechanism				Transcription Factor Info
DT Modulation19	Famotidine inhibits the reaction SLC22A3 protein affects the transport of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
DT Modulation20	Famotidine inhibits the reaction SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
DT Modulation21	Flecainide inhibits the reaction SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[37]
Regulation Mechanism				Transcription Factor Info
DT Modulation22	Guanidine inhibits the reaction SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium analog			[5]
Regulation Mechanism				Transcription Factor Info
DT Modulation23	Histamine inhibits the reaction SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[36]
Regulation Mechanism				Transcription Factor Info
DT Modulation24	Imipramine inhibits the reaction SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[38]
Regulation Mechanism				Transcription Factor Info
DT Modulation25	Imipramine inhibits the reaction SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium analog			[5]
Regulation Mechanism				Transcription Factor Info
DT Modulation26	Ipratropium inhibits the reaction SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[37]
Regulation Mechanism				Transcription Factor Info
DT Modulation27	Lidocaine inhibits the reaction SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[37]
Regulation Mechanism				Transcription Factor Info
DT Modulation28	Metformin inhibits the reaction SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
DT Modulation29	metiprenaline inhibits the reaction SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[8]
Regulation Mechanism				Transcription Factor Info
DT Modulation30	Molsidomine inhibits the reaction SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[37]
Regulation Mechanism				Transcription Factor Info
DT Modulation31	Nifedipine inhibits the reaction SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[37]
Regulation Mechanism				Transcription Factor Info
DT Modulation32	Papaverine inhibits the reaction SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[36]
Regulation Mechanism				Transcription Factor Info
DT Modulation33	Phenoxybenzamine inhibits the reaction SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[8]
Regulation Mechanism				Transcription Factor Info
DT Modulation34	Phentolamine inhibits the reaction SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[36]
Regulation Mechanism				Transcription Factor Info
DT Modulation35	Prazosin inhibits the reaction SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[8]
Regulation Mechanism				Transcription Factor Info
DT Modulation36	Procainamide inhibits the reaction SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium analog			[5]
Regulation Mechanism				Transcription Factor Info
DT Modulation37	Progesterone inhibits the reaction SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[8]
Regulation Mechanism				Transcription Factor Info
DT Modulation38	Propafenone inhibits the reaction SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[37]
Regulation Mechanism				Transcription Factor Info
DT Modulation39	Propranolol inhibits the reaction SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[37]
Regulation Mechanism				Transcription Factor Info
DT Modulation40	pseudoisocyanine inhibits the reaction SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[8]
Regulation Mechanism				Transcription Factor Info
DT Modulation41	Quinidine inhibits the reaction SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
DT Modulation42	Quinine inhibits the reaction SLC22A3 protein results in increased transport of 1-Methyl-4-phenylpyridinium			[2]
Regulation Mechanism				Transcription Factor Info
DT Modulation43	Ranitidine inhibits the reaction SLC22A3 protein affects the transport of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
DT Modulation44	Ranitidine inhibits the reaction SLC22A3 protein results in increased transport of 1-Methyl-4-phenylpyridinium			[2]
Regulation Mechanism				Transcription Factor Info
DT Modulation45	Ranitidine inhibits the reaction SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
DT Modulation46	SK&F 550 inhibits the reaction SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[8]
Regulation Mechanism				Transcription Factor Info
DT Modulation47	SLC22A3 protein polymorphism affects the uptake of 1-Methyl-4-phenylpyridinium			[39]
Regulation Mechanism				Transcription Factor Info
DT Modulation48	SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[8]
Regulation Mechanism				Transcription Factor Info
DT Modulation49	SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium analog			[5]
Regulation Mechanism				Transcription Factor Info
DT Modulation50	Spironolactone inhibits the reaction SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[37]
Regulation Mechanism				Transcription Factor Info
DT Modulation51	Tetraethylammonium inhibits the reaction SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
DT Modulation52	Tetraethylammonium inhibits the reaction SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium analog			[5]
Regulation Mechanism				Transcription Factor Info
DT Modulation53	thioperamide inhibits the reaction SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[36]
Regulation Mechanism				Transcription Factor Info
DT Modulation54	trimazosin inhibits the reaction SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[36]
Regulation Mechanism				Transcription Factor Info
DT Modulation55	Verapamil inhibits the reaction SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[37]
Regulation Mechanism				Transcription Factor Info
2-amino-3,4-dimethylimidazo(4,5-f)quinoline	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	2-amino-3,4-dimethylimidazo(4,5-f)quinoline inhibits the reaction SLC22A3 protein results in increased import of 4-(4-(dimethylamino)styryl)-1-methylpyridinium iodide			[27]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	2-amino-3,4-dimethylimidazo(4,5-f)quinoline results in decreased activity of SLC22A3 protein			[27]
Regulation Mechanism				Transcription Factor Info
2-amino-3,7,8-trimethylimidazo(4,5-f)quinoxaline	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	2-amino-3,7,8-trimethylimidazo(4,5-f)quinoxaline inhibits the reaction SLC22A3 protein results in increased import of 4-(4-(dimethylamino)styryl)-1-methylpyridinium iodide			[27]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	2-amino-3,7,8-trimethylimidazo(4,5-f)quinoxaline results in decreased activity of SLC22A3 protein			[27]
Regulation Mechanism				Transcription Factor Info
2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline inhibits the reaction SLC22A3 protein results in increased import of 4-(4-(dimethylamino)styryl)-1-methylpyridinium iodide			[27]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased activity of SLC22A3 protein			[27]
Regulation Mechanism				Transcription Factor Info
2-amino-3-methyl-3H-imidazo(4,5-f)quinoline	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	2-amino-3-methyl-3H-imidazo(4,5-f)quinoline inhibits the reaction SLC22A3 protein results in increased import of 4-(4-(dimethylamino)styryl)-1-methylpyridinium iodide			[27]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	2-amino-3-methyl-3H-imidazo(4,5-f)quinoline results in decreased activity of SLC22A3 protein			[27]
Regulation Mechanism				Transcription Factor Info
2-amino-3-methylimidazo(4,5-f)quinoxaline	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	2-amino-3-methylimidazo(4,5-f)quinoxaline inhibits the reaction SLC22A3 protein results in increased import of 4-(4-(dimethylamino)styryl)-1-methylpyridinium iodide			[27]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	2-amino-3-methylimidazo(4,5-f)quinoxaline results in decreased activity of SLC22A3 protein			[27]
Regulation Mechanism				Transcription Factor Info
2-amino-6-methyldipyrido(1,2-a-3',2'-d)imidazole	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	2-amino-6-methyldipyrido(1,2-a-3',2'-d)imidazole inhibits the reaction SLC22A3 protein results in increased import of 4-(4-(dimethylamino)styryl)-1-methylpyridinium iodide			[27]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	2-amino-6-methyldipyrido(1,2-a-3',2'-d)imidazole results in decreased activity of SLC22A3 protein			[27]
Regulation Mechanism				Transcription Factor Info
3,4,8-trimethylimidazo(4,5-f)quinoxalin-2-amine	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	3,4,8-trimethylimidazo(4,5-f)quinoxalin-2-amine inhibits the reaction SLC22A3 protein results in increased import of 4-(4-(dimethylamino)styryl)-1-methylpyridinium iodide			[27]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	3,4,8-trimethylimidazo(4,5-f)quinoxalin-2-amine results in decreased activity of SLC22A3 protein			[27]
Regulation Mechanism				Transcription Factor Info
3-amino-1,4-dimethyl-5H-pyrido(4,3-b)indole	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	3-amino-1,4-dimethyl-5H-pyrido(4,3-b)indole inhibits the reaction SLC22A3 protein results in increased import of 4-(4-(dimethylamino)styryl)-1-methylpyridinium iodide			[27]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	3-amino-1,4-dimethyl-5H-pyrido(4,3-b)indole results in decreased activity of SLC22A3 protein			[27]
Regulation Mechanism				Transcription Factor Info
3-amino-1-methyl-5H-pyrido(4,3-b)indole	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	3-amino-1-methyl-5H-pyrido(4,3-b)indole inhibits the reaction SLC22A3 protein results in increased import of 4-(4-(dimethylamino)styryl)-1-methylpyridinium iodide			[27]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	3-amino-1-methyl-5H-pyrido(4,3-b)indole results in decreased activity of SLC22A3 protein			[27]
Regulation Mechanism				Transcription Factor Info
4-(1H-imidazol-4-ylmethyl)piperidine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	4-(1H-imidazol-4-ylmethyl)piperidine inhibits the reaction SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[36]
Regulation Mechanism				Transcription Factor Info
Aldehydes	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Aldehydes results in decreased expression of SLC22A3 mRNA			[41]
Regulation Mechanism				Transcription Factor Info
beclomethasone 17-monopropionate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLC22A3 protein results in increased susceptibility to beclomethasone 17-monopropionate results in decreased transport of Formoterol Fumarate			[42]
Regulation Mechanism				Transcription Factor Info
benzo(b)fluoranthene	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Benzo(a)pyrene co-treated with benzo(b)fluoranthene affects the expression of SLC22A3 mRNA			[43]
Regulation Mechanism				Transcription Factor Info
bisphenol A	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	bisphenol A co-treated with Fulvestrant affects the methylation of SLC22A3 gene			[45]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	bisphenol A results in increased expression of SLC22A3 mRNA			[46]
Regulation Mechanism				Transcription Factor Info
bisphenol S	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	bisphenol S results in increased methylation of SLC22A3 gene			[45]
Regulation Mechanism				Transcription Factor Info
BU 224	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	BU 224 inhibits the reaction SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[36]
Regulation Mechanism				Transcription Factor Info
Budesonide	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Budesonide inhibits the reaction SLC22A3 protein results in increased uptake of Formoterol Fumarate			[47]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	SLC22A3 protein results in increased susceptibility to Budesonide results in decreased transport of Formoterol Fumarate			[42]
Regulation Mechanism				Transcription Factor Info
butyraldehyde	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	butyraldehyde results in decreased expression of SLC22A3 mRNA			[25]
Regulation Mechanism				Transcription Factor Info
Cadmium Chloride	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cadmium Chloride results in increased abundance of Cadmium which results in increased expression of SLC22A3 mRNA			[48]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Cadmium Chloride results in increased expression of SLC22A3 mRNA			[49]
Regulation Mechanism				Transcription Factor Info
Cannabidiol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cannabidiol results in increased expression of SLC22A3 mRNA			[50]
Regulation Mechanism				Transcription Factor Info
Carvedilol	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Carvedilol inhibits the reaction SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[37]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Carvedilol inhibits the reaction SLC22A3 protein results in increased uptake of Metformin			[38]
Regulation Mechanism				Transcription Factor Info
CGP 52608	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	CGP 52608 promotes the reaction RORA protein binds to SLC22A3 gene			[51]
Regulation Mechanism				Transcription Factor Info
Cimetidine	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cimetidine inhibits the reaction SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[38]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Cimetidine inhibits the reaction SLC22A3 protein results in increased uptake of Ethidium			[35]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Cimetidine inhibits the reaction SLC22A3 protein results in increased uptake of Metformin			[38]
Regulation Mechanism				Transcription Factor Info
clobenpropit	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	clobenpropit inhibits the reaction SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[36]
Regulation Mechanism				Transcription Factor Info
cobaltous chloride	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	cobaltous chloride results in decreased expression of SLC22A3 mRNA			[53]
Regulation Mechanism				Transcription Factor Info
desisobutyrylciclesonide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLC22A3 protein results in increased susceptibility to desisobutyrylciclesonide results in decreased transport of Formoterol Fumarate			[42]
Regulation Mechanism				Transcription Factor Info
Digoxin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Digoxin inhibits the reaction SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[37]
Regulation Mechanism				Transcription Factor Info
disprocynium 24	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	disprocynium 24 inhibits the reaction SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[36]
Regulation Mechanism				Transcription Factor Info
Dopamine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLC22A3 protein results in increased uptake of Dopamine			[55]
Regulation Mechanism				Transcription Factor Info
enzalutamide	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	enzalutamide results in decreased expression of SLC22A3 mRNA			[20]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	KDM1A protein promotes the reaction enzalutamide results in decreased expression of SLC22A3 mRNA			[20]
Regulation Mechanism				Transcription Factor Info
Epinephrine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLC22A3 protein results in increased uptake of Epinephrine			[55]
Regulation Mechanism				Transcription Factor Info
Ethidium	5 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	1-Methyl-4-phenylpyridinium inhibits the reaction SLC22A3 protein results in increased uptake of Ethidium			[35]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Cimetidine inhibits the reaction SLC22A3 protein results in increased uptake of Ethidium			[35]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Quinine inhibits the reaction SLC22A3 protein results in increased uptake of Ethidium			[35]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	SLC22A3 protein results in increased uptake of Ethidium			[35]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Tetraethylammonium inhibits the reaction SLC22A3 protein results in increased uptake of Ethidium			[35]
Regulation Mechanism				Transcription Factor Info
Flecainide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Flecainide inhibits the reaction SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[37]
Regulation Mechanism				Transcription Factor Info
Fluticasone	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Fluticasone inhibits the reaction SLC22A3 protein results in increased uptake of Formoterol Fumarate			[47]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	SLC22A3 protein results in increased susceptibility to Fluticasone results in decreased transport of Formoterol Fumarate			[42]
Regulation Mechanism				Transcription Factor Info
Fonofos	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Fonofos results in increased methylation of SLC22A3 promoter			[57]
Regulation Mechanism				Transcription Factor Info
Formoterol Fumarate	8 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Budesonide inhibits the reaction SLC22A3 protein results in increased uptake of Formoterol Fumarate			[47]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Corticosterone inhibits the reaction SLC22A3 protein results in increased uptake of Formoterol Fumarate			[47]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Fluticasone inhibits the reaction SLC22A3 protein results in increased uptake of Formoterol Fumarate			[47]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	SLC22A3 protein results in increased susceptibility to beclomethasone 17-monopropionate results in decreased transport of Formoterol Fumarate			[42]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	SLC22A3 protein results in increased susceptibility to Budesonide results in decreased transport of Formoterol Fumarate			[42]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	SLC22A3 protein results in increased susceptibility to desisobutyrylciclesonide results in decreased transport of Formoterol Fumarate			[42]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	SLC22A3 protein results in increased susceptibility to Fluticasone results in decreased transport of Formoterol Fumarate			[42]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	SLC22A3 protein results in increased uptake of Formoterol Fumarate			[47]
Regulation Mechanism				Transcription Factor Info
Fulvestrant	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	bisphenol A co-treated with Fulvestrant affects the methylation of SLC22A3 gene			[45]
Regulation Mechanism				Transcription Factor Info
Glu-P-2	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Glu-P-2 inhibits the reaction SLC22A3 protein results in increased import of 4-(4-(dimethylamino)styryl)-1-methylpyridinium iodide			[27]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Glu-P-2 results in decreased activity of SLC22A3 protein			[27]
Regulation Mechanism				Transcription Factor Info
Guanidine	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Guanidine inhibits the reaction SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium analog			[5]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	SLC22A3 protein results in increased uptake of Guanidine			[5]
Regulation Mechanism				Transcription Factor Info
Histamine	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Histamine inhibits the reaction SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[36]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	SLC22A3 protein polymorphism affects the uptake of Histamine			[39]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	SLC22A3 protein results in increased uptake of Histamine			[55]
Regulation Mechanism				Transcription Factor Info
Ipratropium	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ipratropium inhibits the reaction SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[37]
Regulation Mechanism				Transcription Factor Info
Lamivudine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLC22A3 protein results in increased uptake of Lamivudine			[58]
Regulation Mechanism				Transcription Factor Info
lead acetate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	lead acetate co-treated with zinc protoporphyrin results in increased expression of SLC22A3 mRNA			[59]
Regulation Mechanism				Transcription Factor Info
Lidocaine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Lidocaine inhibits the reaction SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[37]
Regulation Mechanism				Transcription Factor Info
metiprenaline	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	metiprenaline inhibits the reaction SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[8]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	metiprenaline results in decreased activity of SLC22A3 protein			[8]
Regulation Mechanism				Transcription Factor Info
Molsidomine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Molsidomine inhibits the reaction SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[37]
Regulation Mechanism				Transcription Factor Info
Nifedipine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Nifedipine inhibits the reaction SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[37]
Regulation Mechanism				Transcription Factor Info
Norepinephrine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLC22A3 protein results in increased uptake of Norepinephrine			[55]
Regulation Mechanism				Transcription Factor Info
norharman	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	norharman inhibits the reaction SLC22A3 protein results in increased import of 4-(4-(dimethylamino)styryl)-1-methylpyridinium iodide			[27]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	norharman results in decreased activity of SLC22A3 protein			[27]
Regulation Mechanism				Transcription Factor Info
Paclitaxel	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLC22A3 protein affects the susceptibility to Paclitaxel			[60]
Regulation Mechanism				Transcription Factor Info
Papaverine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Papaverine inhibits the reaction SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[36]
Regulation Mechanism				Transcription Factor Info
Parathion	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Parathion results in increased methylation of SLC22A3 promoter			[57]
Regulation Mechanism				Transcription Factor Info
pentanal	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	pentanal results in decreased expression of SLC22A3 mRNA			[25]
Regulation Mechanism				Transcription Factor Info
Phentolamine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Phentolamine inhibits the reaction SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[36]
Regulation Mechanism				Transcription Factor Info
Propafenone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Propafenone inhibits the reaction SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[37]
Regulation Mechanism				Transcription Factor Info
propionaldehyde	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	propionaldehyde results in decreased expression of SLC22A3 mRNA			[25]
Regulation Mechanism				Transcription Factor Info
Propranolol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Propranolol inhibits the reaction SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[37]
Regulation Mechanism				Transcription Factor Info
pseudoisocyanine	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	pseudoisocyanine inhibits the reaction SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[8]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	SLC22A3 protein results in increased uptake of pseudoisocyanine			[61]
Regulation Mechanism				Transcription Factor Info
Quinidine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Quinidine inhibits the reaction SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
Salmeterol Xinafoate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLC22A3 protein results in increased uptake of Salmeterol Xinafoate			[47]
Regulation Mechanism				Transcription Factor Info
Serotonin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLC22A3 protein results in increased uptake of Serotonin			[55]
Regulation Mechanism				Transcription Factor Info
Silicon Dioxide	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Silicon Dioxide analog results in decreased expression of SLC22A3 mRNA			[62]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Silicon Dioxide analog results in increased expression of SLC22A3 mRNA			[63]
Regulation Mechanism				Transcription Factor Info
SK&F 550	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SK&F 550 inhibits the reaction SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[8]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	SK&F 550 results in decreased activity of SLC22A3 protein			[8]
Regulation Mechanism				Transcription Factor Info
sodium arsenite	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	sodium arsenite results in decreased expression of SLC22A3 mRNA			[30]
Regulation Mechanism				Transcription Factor Info
Sodium Dodecyl Sulfate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sodium Dodecyl Sulfate results in decreased expression of SLC22A3 mRNA			[64]
Regulation Mechanism				Transcription Factor Info
Spironolactone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Spironolactone inhibits the reaction SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[37]
Regulation Mechanism				Transcription Factor Info
Sulpiride	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLC22A3 protein results in increased uptake of Sulpiride			[61]
Regulation Mechanism				Transcription Factor Info
terbufos	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	terbufos results in increased methylation of SLC22A3 promoter			[57]
Regulation Mechanism				Transcription Factor Info
tert-Butylhydroperoxide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	tert-Butylhydroperoxide affects the expression of SLC22A3 mRNA			[18]
Regulation Mechanism				Transcription Factor Info
Tetrachlorodibenzodioxin	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Endosulfan inhibits the reaction Tetrachlorodibenzodioxin results in decreased expression of SLC22A3 mRNA			[32]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Tetrachlorodibenzodioxin affects the expression of SLC22A3 mRNA			[65]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Tetrachlorodibenzodioxin results in decreased expression of SLC22A3 mRNA			[40]
Regulation Mechanism				Transcription Factor Info
thioperamide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	thioperamide inhibits the reaction SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[36]
Regulation Mechanism				Transcription Factor Info
trimazosin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	trimazosin inhibits the reaction SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[36]
Regulation Mechanism				Transcription Factor Info
Trimethoprim	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLC22A3 protein results in increased transport of Trimethoprim			[66]
Regulation Mechanism				Transcription Factor Info
Verapamil	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Verapamil inhibits the reaction SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[37]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Verapamil inhibits the reaction SLC22A3 protein results in increased uptake of Metformin			[38]
Regulation Mechanism				Transcription Factor Info
Vinblastine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLC22A3 protein affects the susceptibility to Vinblastine			[60]
Regulation Mechanism				Transcription Factor Info
Vitamin K 3	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Vitamin K 3 affects the expression of SLC22A3 mRNA			[18]
Regulation Mechanism				Transcription Factor Info
zinc protoporphyrin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	lead acetate co-treated with zinc protoporphyrin results in increased expression of SLC22A3 mRNA			[59]
Regulation Mechanism				Transcription Factor Info

References
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2	Drug specificity and intestinal membrane localization of human organic cation transporters (OCT). Biochem Pharmacol. 2005 Dec 5;70(12):1851-60.
3	Transport of dicationic drugs pentamidine and furamidine by human organic cation transporters. Drug Metab Dispos. 2009 Feb;37(2):424-30.
4	A new chemotype inhibitor for the human organic cation transporter 3 (hOCT3). Bioorg Med Chem Lett. 2017 Sep 15;27(18):4440-4445.
5	Structure, function, and regional distribution of the organic cation transporter OCT3 in the kidney. Am J Physiol Renal Physiol. 2000 Sep;279(3):F449-58.
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26	Defensive and adverse energy-related molecular responses precede tris (1, 3-dichloro-2-propyl) phosphate cytotoxicity. J Appl Toxicol. 2016 May;36(5):649-58.
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51	Identification of potential target genes of ROR-alpha in THP1 and HUVEC cell lines. Exp Cell Res. 2017;353(1):6-15.
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60	Gene expression profiling of 30 cancer cell lines predicts resistance towards 11 anticancer drugs at clinically achieved concentrations. Int J Cancer. 2006;118(7):1699-712.
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