Detail Information of Exogenous Modulation

General Information of Drug Transporter (DT)
DT ID	DTD0006 Transporter Info
Gene Name	SLC22A2
Transporter Name	Organic cation transporter 2
Gene ID	6582
UniProt ID	O15244

Exogenous factors (drugs, dietary constituents, etc.) Modulation of This DT (EGM)
Chemical Compound
DT Modulation1	Quinine inhibits the reaction SLC22A2 protein results in increased transport of 1-Methyl-4-phenylpyridinium			[2]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Quinine inhibits the reaction SLC22A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[57]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Quinine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Quinine inhibits the reaction SLC22A2 protein results in increased uptake of Ethidium			[56]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Quinine results in decreased activity of SLC22A2 protein			[81]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	1-Methyl-4-phenylpyridinium inhibits the reaction SLC22A2 protein results in increased uptake of Cimetidine			[55]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Cimetidine inhibits the reaction SLC22A2 protein affects the transport of Tetraethylammonium			[55]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Cimetidine inhibits the reaction SLC22A2 protein polymorphism results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Cimetidine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Cimetidine inhibits the reaction SLC22A2 protein results in increased uptake of Ethidium			[56]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	p-Aminohippuric Acid inhibits the reaction SLC22A2 protein results in increased uptake of Cimetidine			[55]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	SLC22A2 gene polymorphism results in decreased susceptibility to Cimetidine			[71]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	SLC22A2 protein results in increased uptake of Cimetidine			[55]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Ranitidine inhibits the reaction SLC22A2 protein results in increased transport of 1-Methyl-4-phenylpyridinium			[2]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Ranitidine inhibits the reaction SLC22A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	SLC22A2 protein results in increased uptake of Ranitidine			[12]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	3-amino-1,4-dimethyl-5H-pyrido(4,3-b)indole inhibits the reaction SLC22A2 protein results in increased import of Tetraethylammonium			[50]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	3-amino-1-methyl-5H-pyrido(4,3-b)indole inhibits the reaction SLC22A2 protein results in increased import of Tetraethylammonium			[50]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Aconitine inhibits the reaction SLC22A2 protein results in increased uptake of Tetraethylammonium			[30]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Amitriptyline inhibits the reaction SLC22A2 protein results in increased import of Tetraethylammonium			[32]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Amitriptyline inhibits the reaction SLC22A2 protein results in increased uptake of Tetraethylammonium			[30]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Atropine inhibits the reaction SLC22A2 protein results in increased uptake of Tetraethylammonium			[30]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	bisphenol F promotes the reaction SLC22A2 protein results in increased uptake of Tetraethylammonium			[69]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	bisphenol S promotes the reaction SLC22A2 protein results in increased uptake of Tetraethylammonium			[69]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	Chlorpyrifos inhibits the reaction SLC22A2 protein results in increased uptake of Tetraethylammonium			[30]
Regulation Mechanism				Transcription Factor Info
DT Modulation10	Cimetidine inhibits the reaction SLC22A2 protein affects the transport of Tetraethylammonium			[55]
Regulation Mechanism				Transcription Factor Info
DT Modulation11	Famotidine inhibits the reaction SLC22A2 protein affects the transport of Tetraethylammonium			[55]
Regulation Mechanism				Transcription Factor Info
DT Modulation12	Fenitrothion inhibits the reaction SLC22A2 protein results in increased uptake of Tetraethylammonium			[30]
Regulation Mechanism				Transcription Factor Info
DT Modulation13	Haloperidol inhibits the reaction SLC22A2 protein results in increased uptake of Tetraethylammonium			[30]
Regulation Mechanism				Transcription Factor Info
DT Modulation14	Lidocaine inhibits the reaction SLC22A2 protein results in increased uptake of Tetraethylammonium			[30]
Regulation Mechanism				Transcription Factor Info
DT Modulation15	Malathion inhibits the reaction SLC22A2 protein results in increased uptake of Tetraethylammonium			[30]
Regulation Mechanism				Transcription Factor Info
DT Modulation16	Mercuric Chloride results in decreased activity of SLC22A2 protein which results in decreased uptake of Tetraethylammonium			[48]
Regulation Mechanism				Transcription Factor Info
DT Modulation17	Mianserin inhibits the reaction SLC22A2 protein results in increased uptake of Tetraethylammonium			[30]
Regulation Mechanism				Transcription Factor Info
DT Modulation18	Nicotine inhibits the reaction SLC22A2 protein results in increased uptake of Tetraethylammonium			[30]
Regulation Mechanism				Transcription Factor Info
DT Modulation19	SLC22A2 gene polymorphism results in decreased uptake of Tetraethylammonium			[59]
Regulation Mechanism				Transcription Factor Info
DT Modulation20	SLC22A2 protein affects the transport of Tetraethylammonium			[55]
Regulation Mechanism				Transcription Factor Info
DT Modulation21	SLC22A2 protein results in increased import of Tetraethylammonium			[32]
Regulation Mechanism				Transcription Factor Info
DT Modulation22	SLC22A2 protein results in increased uptake of Tetraethylammonium			[12]
Regulation Mechanism				Transcription Factor Info
DT Modulation23	SLC22A2 results in increased import of Tetraethylammonium			[5]
Regulation Mechanism				Transcription Factor Info
DT Modulation24	tetrabromobisphenol A inhibits the reaction SLC22A2 protein results in increased uptake of Tetraethylammonium			[69]
Regulation Mechanism				Transcription Factor Info
DT Modulation25	Tetraethylammonium inhibits the reaction SLC22A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
DT Modulation26	Tetraethylammonium inhibits the reaction SLC22A2 protein results in increased uptake of Ethidium			[56]
Regulation Mechanism				Transcription Factor Info
DT Modulation27	Tobacco Smoke Pollution inhibits the reaction SLC22A2 protein results in increased import of Tetraethylammonium			[32]
Regulation Mechanism				Transcription Factor Info
DT Modulation28	Triazolam inhibits the reaction SLC22A2 protein results in increased uptake of Tetraethylammonium			[30]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Clonidine inhibits the reaction SLC22A2 protein results in increased transport of 1-Methyl-4-phenylpyridinium			[2]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Clonidine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Diphenhydramine inhibits the reaction SLC22A2 protein results in increased transport of 1-Methyl-4-phenylpyridinium			[2]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Diphenhydramine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Carvedilol inhibits the reaction SLC22A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[58]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Carvedilol inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Carvedilol inhibits the reaction SLC22A2 protein results in increased uptake of Metformin			[58]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Propranolol inhibits the reaction SLC22A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[58]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Propranolol inhibits the reaction SLC22A2 protein results in increased uptake of Metformin			[58]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Verapamil inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Phenformin inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Phenoxybenzamine inhibits the reaction SLC22A2 protein affects the transport of Metformin			[76]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Phenoxybenzamine inhibits the reaction SLC22A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[23]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Phenoxybenzamine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Phenoxybenzamine results in decreased activity of SLC22A2 protein			[23]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Famotidine inhibits the reaction SLC22A2 protein affects the transport of Tetraethylammonium			[55]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Famotidine inhibits the reaction SLC22A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Famotidine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	SLC22A2 protein results in increased uptake of Famotidine			[12]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Atropine inhibits the reaction SLC22A2 protein results in increased transport of 1-Methyl-4-phenylpyridinium			[2]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Atropine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Atropine inhibits the reaction SLC22A2 protein results in increased uptake of Tetraethylammonium			[30]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Etilefrine inhibits the reaction SLC22A2 protein results in increased transport of 1-Methyl-4-phenylpyridinium			[2]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Pentamidine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Amitriptyline inhibits the reaction SLC22A2 protein results in increased import of 4-(4-(dimethylamino)styryl)-1-methylpyridinium iodide			[50]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Amitriptyline inhibits the reaction SLC22A2 protein results in increased import of Tetraethylammonium			[32]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Amitriptyline inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Amitriptyline inhibits the reaction SLC22A2 protein results in increased uptake of Tetraethylammonium			[30]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Amitriptyline results in decreased activity of SLC22A2 protein			[32]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Chloroquine inhibits the reaction SLC22A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[57]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Chlorpromazine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Disopyramide inhibits the reaction SLC22A2 protein polymorphism results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Disopyramide inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Doxepin inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Imipramine inhibits the reaction SLC22A2 protein polymorphism results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Imipramine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Mefloquine inhibits the reaction SLC22A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[57]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Desipramine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Aconitine inhibits the reaction SLC22A2 protein results in increased uptake of Tetraethylammonium			[30]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Prazosin inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Metoprolol inhibits the reaction SLC22A2 protein results in increased uptake of Metformin			[58]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Indomethacin results in decreased activity of SLC22A2 protein			[39]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Naproxen results in decreased activity of SLC22A2 protein			[39]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Piroxicam results in decreased activity of SLC22A2 protein			[39]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Sulindac results in decreased activity of SLC22A2 protein			[39]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	SLC22A2 gene polymorphism inhibits the reaction Cisplatin results in increased expression of CST3			[71]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	SLC22A2 gene polymorphism results in decreased susceptibility to Cisplatin			[71]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Budesonide inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Triazolam inhibits the reaction SLC22A2 protein results in increased uptake of Tetraethylammonium			[30]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Diazepam inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Haloperidol inhibits the reaction SLC22A2 protein results in increased uptake of Tetraethylammonium			[30]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Lidocaine inhibits the reaction SLC22A2 protein results in increased uptake of Tetraethylammonium			[30]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Mianserin inhibits the reaction SLC22A2 protein results in increased uptake of Tetraethylammonium			[30]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Mercuric Chloride results in decreased activity of SLC22A2 protein			[48]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Mercuric Chloride results in decreased activity of SLC22A2 protein which results in decreased uptake of Tetraethylammonium			[48]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine inhibits the reaction SLC22A2 protein results in increased import of 4-(4-(dimethylamino)styryl)-1-methylpyridinium iodide			[50]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased activity of SLC22A2 protein			[50]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Thiamethoxam results in decreased activity of SLC22A2 protein			[51]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Benzo(a)pyrene affects the methylation of SLC22A2 promoter			[66]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Benzo(a)pyrene results in increased methylation of SLC22A2 exon			[66]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Benzo(a)pyrene results in increased mutagenesis of SLC22A2 gene			[67]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Fenitrothion inhibits the reaction SLC22A2 protein results in increased uptake of Tetraethylammonium			[30]
Regulation Mechanism				Transcription Factor Info
17-alpha-Hydroxyprogesterone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	17-alpha-Hydroxyprogesterone inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
1-benzylimidazole	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	1-benzylimidazole inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
1-Methyl-4-phenylpyridinium	28 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	1-Methyl-4-phenylpyridinium inhibits the reaction SLC22A2 protein results in increased uptake of Cimetidine			[55]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	1-Methyl-4-phenylpyridinium inhibits the reaction SLC22A2 protein results in increased uptake of Ethidium			[56]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	artemisinin inhibits the reaction SLC22A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[57]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Atropine inhibits the reaction SLC22A2 protein results in increased transport of 1-Methyl-4-phenylpyridinium			[2]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Carvedilol inhibits the reaction SLC22A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[58]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Chloroquine inhibits the reaction SLC22A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[57]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	Clonidine inhibits the reaction SLC22A2 protein results in increased transport of 1-Methyl-4-phenylpyridinium			[2]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	Diphenhydramine inhibits the reaction SLC22A2 protein results in increased transport of 1-Methyl-4-phenylpyridinium			[2]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	Ethidium inhibits the reaction SLC22A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[56]
Regulation Mechanism				Transcription Factor Info
DT Modulation10	Etilefrine inhibits the reaction SLC22A2 protein results in increased transport of 1-Methyl-4-phenylpyridinium			[2]
Regulation Mechanism				Transcription Factor Info
DT Modulation11	Famotidine inhibits the reaction SLC22A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
DT Modulation12	Mefloquine inhibits the reaction SLC22A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[57]
Regulation Mechanism				Transcription Factor Info
DT Modulation13	Metformin inhibits the reaction SLC22A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
DT Modulation14	Phenoxybenzamine inhibits the reaction SLC22A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[23]
Regulation Mechanism				Transcription Factor Info
DT Modulation15	Propranolol inhibits the reaction SLC22A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[58]
Regulation Mechanism				Transcription Factor Info
DT Modulation16	pseudoisocyanine inhibits the reaction SLC22A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[23]
Regulation Mechanism				Transcription Factor Info
DT Modulation17	Pyrimethamine inhibits the reaction SLC22A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[57]
Regulation Mechanism				Transcription Factor Info
DT Modulation18	Quinidine inhibits the reaction SLC22A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
DT Modulation19	Quinine inhibits the reaction SLC22A2 protein results in increased transport of 1-Methyl-4-phenylpyridinium			[2]
Regulation Mechanism				Transcription Factor Info
DT Modulation20	Quinine inhibits the reaction SLC22A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[57]
Regulation Mechanism				Transcription Factor Info
DT Modulation21	Ranitidine inhibits the reaction SLC22A2 protein results in increased transport of 1-Methyl-4-phenylpyridinium			[2]
Regulation Mechanism				Transcription Factor Info
DT Modulation22	Ranitidine inhibits the reaction SLC22A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
DT Modulation23	SK&F 550 inhibits the reaction SLC22A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[23]
Regulation Mechanism				Transcription Factor Info
DT Modulation24	SLC22A2 gene polymorphism results in decreased uptake of 1-Methyl-4-phenylpyridinium			[59]
Regulation Mechanism				Transcription Factor Info
DT Modulation25	SLC22A2 protein results in increased transport of 1-Methyl-4-phenylpyridinium			[60]
Regulation Mechanism				Transcription Factor Info
DT Modulation26	SLC22A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[23]
Regulation Mechanism				Transcription Factor Info
DT Modulation27	SLC22A2 results in increased import of 1-Methyl-4-phenylpyridinium			[5]
Regulation Mechanism				Transcription Factor Info
DT Modulation28	Tetraethylammonium inhibits the reaction SLC22A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
2-amino-3,4-dimethylimidazo(4,5-f)quinoline	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	2-amino-3,4-dimethylimidazo(4,5-f)quinoline inhibits the reaction SLC22A2 protein results in increased import of 4-(4-(dimethylamino)styryl)-1-methylpyridinium iodide			[50]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	2-amino-3,4-dimethylimidazo(4,5-f)quinoline results in decreased activity of SLC22A2 protein			[50]
Regulation Mechanism				Transcription Factor Info
2-amino-3,7,8-trimethylimidazo(4,5-f)quinoxaline	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	2-amino-3,7,8-trimethylimidazo(4,5-f)quinoxaline inhibits the reaction SLC22A2 protein results in increased import of 4-(4-(dimethylamino)styryl)-1-methylpyridinium iodide			[50]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	2-amino-3,7,8-trimethylimidazo(4,5-f)quinoxaline results in decreased activity of SLC22A2 protein			[50]
Regulation Mechanism				Transcription Factor Info
2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline inhibits the reaction SLC22A2 protein results in increased import of 4-(4-(dimethylamino)styryl)-1-methylpyridinium iodide			[50]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased activity of SLC22A2 protein			[50]
Regulation Mechanism				Transcription Factor Info
2-amino-3-methyl-3H-imidazo(4,5-f)quinoline	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	2-amino-3-methyl-3H-imidazo(4,5-f)quinoline inhibits the reaction SLC22A2 protein results in increased import of 4-(4-(dimethylamino)styryl)-1-methylpyridinium iodide			[50]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	2-amino-3-methyl-3H-imidazo(4,5-f)quinoline results in decreased activity of SLC22A2 protein			[50]
Regulation Mechanism				Transcription Factor Info
2-amino-3-methyl-9H-pyrido(2,3-b)indole	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	2-amino-3-methyl-9H-pyrido(2,3-b)indole inhibits the reaction SLC22A2 protein results in increased import of 4-(4-(dimethylamino)styryl)-1-methylpyridinium iodide			[50]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	2-amino-3-methyl-9H-pyrido(2,3-b)indole results in decreased activity of SLC22A2 protein			[50]
Regulation Mechanism				Transcription Factor Info
2-amino-3-methylimidazo(4,5-f)quinoxaline	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	2-amino-3-methylimidazo(4,5-f)quinoxaline inhibits the reaction SLC22A2 protein results in increased import of 4-(4-(dimethylamino)styryl)-1-methylpyridinium iodide			[50]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	2-amino-3-methylimidazo(4,5-f)quinoxaline results in decreased activity of SLC22A2 protein			[50]
Regulation Mechanism				Transcription Factor Info
2-amino-6-methyldipyrido(1,2-a-3',2'-d)imidazole	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	2-amino-6-methyldipyrido(1,2-a-3',2'-d)imidazole inhibits the reaction SLC22A2 protein results in increased import of 4-(4-(dimethylamino)styryl)-1-methylpyridinium iodide			[50]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	2-amino-6-methyldipyrido(1,2-a-3',2'-d)imidazole results in decreased activity of SLC22A2 protein			[50]
Regulation Mechanism				Transcription Factor Info
2-amino-9H-pyrido(2,3-b)indole	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	2-amino-9H-pyrido(2,3-b)indole inhibits the reaction SLC22A2 protein results in increased import of 4-(4-(dimethylamino)styryl)-1-methylpyridinium iodide			[50]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	2-amino-9H-pyrido(2,3-b)indole results in decreased activity of SLC22A2 protein			[50]
Regulation Mechanism				Transcription Factor Info
3,3',4',5-tetrachlorosalicylanilide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	3,3',4',5-tetrachlorosalicylanilide inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
3,4,8-trimethylimidazo(4,5-f)quinoxalin-2-amine	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	3,4,8-trimethylimidazo(4,5-f)quinoxalin-2-amine inhibits the reaction SLC22A2 protein results in increased import of 4-(4-(dimethylamino)styryl)-1-methylpyridinium iodide			[50]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	3,4,8-trimethylimidazo(4,5-f)quinoxalin-2-amine results in decreased activity of SLC22A2 protein			[50]
Regulation Mechanism				Transcription Factor Info
3-amino-1,4-dimethyl-5H-pyrido(4,3-b)indole	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	3-amino-1,4-dimethyl-5H-pyrido(4,3-b)indole inhibits the reaction SLC22A2 protein results in increased import of 4-(4-(dimethylamino)styryl)-1-methylpyridinium iodide			[50]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	3-amino-1,4-dimethyl-5H-pyrido(4,3-b)indole inhibits the reaction SLC22A2 protein results in increased import of Tetraethylammonium			[50]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	3-amino-1,4-dimethyl-5H-pyrido(4,3-b)indole results in decreased activity of SLC22A2 protein			[50]
Regulation Mechanism				Transcription Factor Info
3-amino-1-methyl-5H-pyrido(4,3-b)indole	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	3-amino-1-methyl-5H-pyrido(4,3-b)indole inhibits the reaction SLC22A2 protein results in increased import of 4-(4-(dimethylamino)styryl)-1-methylpyridinium iodide			[50]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	3-amino-1-methyl-5H-pyrido(4,3-b)indole inhibits the reaction SLC22A2 protein results in increased import of Tetraethylammonium			[50]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	3-amino-1-methyl-5H-pyrido(4,3-b)indole results in decreased activity of SLC22A2 protein			[50]
Regulation Mechanism				Transcription Factor Info
4-(4-dimethylaminostyryl)-1-methylpyridinium	246 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	17-alpha-Hydroxyprogesterone inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	1-benzylimidazole inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	3,3',4',5-tetrachlorosalicylanilide inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Aclarubicin inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Adapalene inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	adrenosterone inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	Alprazolam inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	Alprenolol inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	Amiloride inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation10	Aminacrine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation11	amitraz inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation12	Amitriptyline inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation13	Anastrozole inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation14	Androsterone inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation15	Antazoline inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation16	Apomorphine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation17	Atropine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation18	Auranofin inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation19	azelastine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation20	Azithromycin inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation21	bazedoxifene inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation22	Beclomethasone inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation23	benoxinate inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation24	Benzethonium inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation25	Benztropine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation26	Bithionol inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation27	bopindolol inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation28	Bretylium Tosylate inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation29	brilliant green inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation30	Brimonidine Tartrate inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation31	Bromhexine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation32	Brompheniramine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation33	Budesonide inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation34	buflomedil inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation35	Bupropion inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation36	Buspirone inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation37	butenafine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation38	butylparaben inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation39	Butylscopolammonium Bromide inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation40	Capsaicin inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation41	carbinoxamine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation42	Carvedilol inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation43	Chlorhexidine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation44	Chlormadinone Acetate inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation45	chlorphenesin carbamate inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation46	Chlorpheniramine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation47	Chlorpromazine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation48	Cilostazol inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation49	Cimetidine inhibits the reaction SLC22A2 protein polymorphism results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation50	Cimetidine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation51	Cisapride inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation52	clebopride inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation53	clidinium inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation54	clomacran inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation55	Clomipramine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation56	Clonidine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation57	clorprenaline inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation58	Clozapine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation59	Cortisone inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation60	cyclobenzaprine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation61	Cyproheptadine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation62	cyromazine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation63	Dasatinib inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[61]
Regulation Mechanism				Transcription Factor Info
DT Modulation64	Dequalinium inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation65	Desipramine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation66	desloratadine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation67	Desoximetasone inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation68	dexbrompheniramine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation69	dexchlorpheniramine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation70	Dexfenfluramine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation71	Dextromethorphan inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation72	Dextropropoxyphene inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation73	Diazepam inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation74	Dicyclomine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation75	Digitonin inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation76	Dimenhydrinate inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation77	Diphenhydramine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation78	diphenidol inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation79	diphenylguanidine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation80	Dipyridamole inhibits the reaction SLC22A2 protein polymorphism results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation81	Dipyridamole inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation82	Disopyramide inhibits the reaction SLC22A2 protein polymorphism results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation83	Disopyramide inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation84	Domperidone inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation85	Donepezil inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation86	Doxazosin inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation87	Doxepin inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation88	Droperidol inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation89	dyclonine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation90	Econazole inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation91	epalrestat inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation92	eperisone inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation93	epinastine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation94	Estrone inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation95	exemestane inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation96	Famotidine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation97	Finasteride inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation98	Flumazenil inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation99	Fluorometholone inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation100	Fluoxetine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation101	Fluphenazine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation102	Flurandrenolone inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation103	Gabexate inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation104	Gentian Violet inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation105	Glycyrrhizic Acid inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation106	Granisetron inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation107	Guanabenz inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation108	Guanfacine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation109	Halcinonide inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation110	homatropine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation111	homochlorocyclizine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation112	Hydralazine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation113	Hydrocortisone inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation114	Hydroxyzine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation115	Hyoscyamine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation116	idebenone inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation117	Imatinib Mesylate inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation118	Imipramine inhibits the reaction SLC22A2 protein polymorphism results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation119	Imipramine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation120	Indapamide inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation121	Ipratropium inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation122	isopropamide iodide inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation123	Kainic Acid inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation124	Ketotifen inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation125	L 744832 inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation126	lafutidine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation127	Lansoprazole inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation128	Letrozole inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation129	Leuprolide inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation130	Lisuride inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation131	Loperamide inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation132	lysergol inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation133	Maprotiline inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation134	mebeverine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation135	Mechlorethamine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation136	Medroxyprogesterone inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation137	Megestrol Acetate inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation138	Melatonin inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation139	mepazine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation140	mepenzolic acid inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation141	mestanolone inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation142	Methyltestosterone inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation143	Metoclopramide inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation144	Miconazole inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation145	Mirtazapine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation146	monobenzone inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation147	mosapride inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation148	moxonidine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation149	Mycophenolic Acid inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation150	myrtecaine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation151	Nalbuphine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation152	naloxonazine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation153	Nandrolone inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation154	Naphazoline inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation155	nefazodone inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation156	Nicardipine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation157	nifekalant inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation158	nimetazepam inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation159	Nocodazole inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation160	Norethindrone inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation161	Norfloxacin inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation162	Nortriptyline inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation163	Noscapine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation164	Nylidrin inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation165	Olanzapine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation166	Omeprazole inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation167	Ondansetron inhibits the reaction SLC22A2 protein polymorphism results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation168	Ondansetron inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation169	Orlistat inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation170	Orphenadrine inhibits the reaction SLC22A2 protein polymorphism results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation171	Orphenadrine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation172	oxatomide inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation173	oxiconazole inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation174	oxybutynin inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation175	Oxymetazoline inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation176	Oxymetholone inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation177	Paroxetine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation178	parthenolide inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation179	Pentamidine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation180	perfluorodecalin inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation181	Pergolide inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation182	Perhexiline inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation183	perospirone inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation184	Perphenazine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation185	Phenelzine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation186	Phenformin inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation187	Phenoxybenzamine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation188	Phentolamine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation189	phenyltoloxamine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation190	Pilocarpine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation191	Pioglitazone inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation192	Piracetam inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation193	Polyphenols inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation194	pralidoxime inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation195	Praziquantel inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation196	Prazosin inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation197	Prednisone inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation198	pridinol inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation199	Primaquine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation200	prinomastat inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation201	Procyclidine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation202	Promazine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation203	Propantheline inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation204	proxymetacaine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation205	Pyrilamine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation206	Quinidine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation207	Quinine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation208	Rabeprazole inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation209	Raloxifene Hydrochloride inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation210	Scopolamine Derivatives inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation211	Selegiline inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation212	Semustine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation213	Sildenafil Citrate inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation214	SLC22A2 protein polymorphism results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation215	SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation216	Sparteine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation217	Spiperone inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation218	Spironolactone inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation219	Strychnine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation220	sulconazole inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation221	Tacrine inhibits the reaction SLC22A2 protein polymorphism results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation222	Tacrine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation223	Tegafur inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation224	Telmisartan inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation225	Terbutaline inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation226	terconazole inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation227	Tetracaine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation228	tetrahydrozoline inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation229	Thalidomide inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation230	Thioridazine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation231	Tolazoline inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation232	Tolperisone inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation233	Tolterodine Tartrate inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation234	Trazodone inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation235	Tretinoin inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation236	Triamcinolone Acetonide inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation237	Trihexyphenidyl inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation238	Trimipramine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation239	Tripelennamine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation240	Tropisetron inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation241	valdecoxib inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation242	Verapamil inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation243	VX-745 inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation244	xylometazoline inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation245	zafirlukast inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation246	Zolpidem inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
AB-FUBINACA	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	AB-FUBINACA results in decreased activity of SLC22A2 protein			[62]
Regulation Mechanism				Transcription Factor Info
abrine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	abrine results in increased expression of SLC22A2 mRNA			[63]
Regulation Mechanism				Transcription Factor Info
acetamiprid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	acetamiprid results in decreased activity of SLC22A2 protein			[51]
Regulation Mechanism				Transcription Factor Info
Aclarubicin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Aclarubicin inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Adapalene	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Adapalene inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
adrenosterone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	adrenosterone inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Alprazolam	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Alprazolam inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Alprenolol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Alprenolol inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Amiloride	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Amiloride inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Aminacrine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Aminacrine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
amitraz	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	amitraz inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Anastrozole	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Anastrozole inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Androsterone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Androsterone inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Antazoline	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Antazoline inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Apomorphine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Apomorphine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
artemisinin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	artemisinin inhibits the reaction SLC22A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[57]
Regulation Mechanism				Transcription Factor Info
Auranofin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Auranofin inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
azelastine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	azelastine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Azithromycin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Azithromycin inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
bazedoxifene	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	bazedoxifene inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Beclomethasone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Beclomethasone inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
benoxinate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	benoxinate inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Benzethonium	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Benzethonium inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Benztropine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Benztropine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Bisoprolol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Bisoprolol inhibits the reaction SLC22A2 protein results in increased uptake of Metformin			[58]
Regulation Mechanism				Transcription Factor Info
bisphenol A	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	bisphenol A co-treated with Fulvestrant results in decreased methylation of SLC22A2 gene			[68]
Regulation Mechanism				Transcription Factor Info
bisphenol F	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	bisphenol F promotes the reaction SLC22A2 protein results in increased uptake of Tetraethylammonium			[69]
Regulation Mechanism				Transcription Factor Info
bisphenol S	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	bisphenol S promotes the reaction SLC22A2 protein results in increased uptake of Tetraethylammonium			[69]
Regulation Mechanism				Transcription Factor Info
Bithionol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Bithionol inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
bopindolol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	bopindolol inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Bretylium Tosylate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Bretylium Tosylate inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
brilliant green	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	brilliant green inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Brimonidine Tartrate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Brimonidine Tartrate inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Bromhexine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Bromhexine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Brompheniramine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Brompheniramine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
buflomedil	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	buflomedil inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Bupropion	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Bupropion inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Buspirone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Buspirone inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
butenafine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	butenafine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
butylparaben	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	butylparaben inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Butylscopolammonium Bromide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Butylscopolammonium Bromide inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Capsaicin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Capsaicin inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
carbinoxamine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	carbinoxamine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
CGP 52608	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	CGP 52608 promotes the reaction RORA protein binds to SLC22A2 gene			[70]
Regulation Mechanism				Transcription Factor Info
Chlorhexidine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Chlorhexidine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Chlormadinone Acetate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Chlormadinone Acetate inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
chlorphenesin carbamate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	chlorphenesin carbamate inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Chlorpheniramine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Chlorpheniramine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Cilostazol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cilostazol inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Cisapride	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cisapride inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
clebopride	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	clebopride inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
clidinium	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	clidinium inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
clomacran	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	clomacran inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Clomipramine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Clomipramine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
clorprenaline	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	clorprenaline inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
clothianidin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	clothianidin results in decreased activity of SLC22A2 protein			[51]
Regulation Mechanism				Transcription Factor Info
Clozapine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Clozapine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Cortisone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cortisone inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
cyclobenzaprine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	cyclobenzaprine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Cyproheptadine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cyproheptadine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
cyromazine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	cyromazine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Dasatinib	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Dasatinib inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[61]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Dasatinib inhibits the reaction SLC22A2 protein results in increased uptake of Oxaliplatin			[61]
Regulation Mechanism				Transcription Factor Info
Dequalinium	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Dequalinium inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
desloratadine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	desloratadine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Desoximetasone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Desoximetasone inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
dexbrompheniramine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	dexbrompheniramine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
dexchlorpheniramine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	dexchlorpheniramine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Dexfenfluramine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Dexfenfluramine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Dextromethorphan	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Dextromethorphan inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Dextropropoxyphene	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Dextropropoxyphene inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Dicyclomine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Dicyclomine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Digitonin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Digitonin inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Dimenhydrinate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Dimenhydrinate inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
diphenidol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	diphenidol inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
diphenylguanidine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	diphenylguanidine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Dipyridamole	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Dipyridamole inhibits the reaction SLC22A2 protein polymorphism results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Dipyridamole inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Domperidone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Domperidone inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Donepezil	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Donepezil inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Doxazosin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Doxazosin inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Droperidol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Droperidol inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
dyclonine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	dyclonine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Econazole	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Econazole inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
epalrestat	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	epalrestat inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
eperisone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	eperisone inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
epinastine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	epinastine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Estrone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Estrone inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Ethidium	6 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	1-Methyl-4-phenylpyridinium inhibits the reaction SLC22A2 protein results in increased uptake of Ethidium			[56]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Cimetidine inhibits the reaction SLC22A2 protein results in increased uptake of Ethidium			[56]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Ethidium inhibits the reaction SLC22A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[56]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Quinine inhibits the reaction SLC22A2 protein results in increased uptake of Ethidium			[56]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	SLC22A2 protein results in increased uptake of Ethidium			[56]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Tetraethylammonium inhibits the reaction SLC22A2 protein results in increased uptake of Ethidium			[56]
Regulation Mechanism				Transcription Factor Info
exemestane	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	exemestane inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Finasteride	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Finasteride inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Flumazenil	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Flumazenil inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Fluorometholone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Fluorometholone inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Fluoxetine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Fluoxetine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Fluphenazine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Fluphenazine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Flurandrenolone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Flurandrenolone inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Fulvestrant	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	bisphenol A co-treated with Fulvestrant results in decreased methylation of SLC22A2 gene			[68]
Regulation Mechanism				Transcription Factor Info
Gabexate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Gabexate inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Gentamicins	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLC22A2 protein results in increased transport of Gentamicins			[72]
Regulation Mechanism				Transcription Factor Info
Gentian Violet	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Gentian Violet inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Glu-P-2	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Glu-P-2 inhibits the reaction SLC22A2 protein results in increased import of 4-(4-(dimethylamino)styryl)-1-methylpyridinium iodide			[50]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Glu-P-2 results in decreased activity of SLC22A2 protein			[50]
Regulation Mechanism				Transcription Factor Info
Glycyrrhizic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Glycyrrhizic Acid inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Granisetron	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Granisetron inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Guanabenz	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Guanabenz inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Guanfacine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Guanfacine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Halcinonide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Halcinonide inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
harman	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	harman inhibits the reaction SLC22A2 protein results in increased import of 4-(4-(dimethylamino)styryl)-1-methylpyridinium iodide			[50]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	harman results in decreased activity of SLC22A2 protein			[50]
Regulation Mechanism				Transcription Factor Info
homatropine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	homatropine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
homochlorocyclizine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	homochlorocyclizine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Hydralazine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Hydralazine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Hydrocortisone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Hydrocortisone inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Hydroxyzine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Hydroxyzine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Hyoscyamine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Hyoscyamine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
idebenone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	idebenone inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Imatinib Mesylate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Imatinib Mesylate inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Indapamide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Indapamide inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Ipratropium	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ipratropium inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
isopropamide iodide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	isopropamide iodide inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Kainic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Kainic Acid inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Ketotifen	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ketotifen inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
L 744832	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	L 744832 inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
lafutidine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	lafutidine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Lamivudine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLC22A2 protein results in increased uptake of Lamivudine			[73]
Regulation Mechanism				Transcription Factor Info
Lansoprazole	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Lansoprazole inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Letrozole	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Letrozole inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Leuprolide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Leuprolide inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
licochalcone B	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	licochalcone B results in decreased expression of SLC22A2 mRNA			[74]
Regulation Mechanism				Transcription Factor Info
Lisuride	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Lisuride inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Loperamide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Loperamide inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
lysergol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	lysergol inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Maprotiline	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Maprotiline inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
mebeverine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	mebeverine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Mechlorethamine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Mechlorethamine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Medroxyprogesterone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Medroxyprogesterone inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Megestrol Acetate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Megestrol Acetate inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Melatonin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Melatonin inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
mepazine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	mepazine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
mepenzolic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	mepenzolic acid inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
mestanolone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	mestanolone inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Methyltestosterone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Methyltestosterone inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Metoclopramide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Metoclopramide inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Miconazole	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Miconazole inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Mirtazapine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Mirtazapine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
monobenzone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	monobenzone inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
mosapride	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	mosapride inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
moxonidine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	moxonidine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Mycophenolic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Mycophenolic Acid inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
myrtecaine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	myrtecaine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
N(1)-methylnicotinamide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLC22A2 results in increased import of N(1)-methylnicotinamide			[5]
Regulation Mechanism				Transcription Factor Info
Nalbuphine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Nalbuphine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
naloxonazine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	naloxonazine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Nandrolone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Nandrolone inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Naphazoline	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Naphazoline inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
nefazodone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	nefazodone inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Nicardipine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Nicardipine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Nicotine	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Nicotine inhibits the reaction SLC22A2 protein results in increased uptake of Tetraethylammonium			[30]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	SLC22A2 gene SNP affects the susceptibility to Nicotine			[77]
Regulation Mechanism				Transcription Factor Info
nifekalant	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	nifekalant inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
nimetazepam	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	nimetazepam inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
nitenpyram	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	nitenpyram results in decreased activity of SLC22A2 protein			[51]
Regulation Mechanism				Transcription Factor Info
Nocodazole	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Nocodazole inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Norethindrone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Norethindrone inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Norfloxacin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Norfloxacin inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
norharman	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	norharman inhibits the reaction SLC22A2 protein results in increased import of 4-(4-(dimethylamino)styryl)-1-methylpyridinium iodide			[50]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	norharman results in decreased activity of SLC22A2 protein			[50]
Regulation Mechanism				Transcription Factor Info
Nortriptyline	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Nortriptyline inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Noscapine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Noscapine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Nylidrin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Nylidrin inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Olanzapine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Olanzapine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Omeprazole	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Omeprazole inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Ondansetron	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ondansetron inhibits the reaction SLC22A2 protein polymorphism results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Ondansetron inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Ondansetron inhibits the reaction SLC22A2 protein results in increased uptake of Metformin			[75]
Regulation Mechanism				Transcription Factor Info
Orlistat	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Orlistat inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Orphenadrine	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Orphenadrine inhibits the reaction SLC22A2 protein polymorphism results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Orphenadrine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Oxaliplatin	5 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Dasatinib inhibits the reaction SLC22A2 protein results in increased uptake of Oxaliplatin			[61]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	SLC22A2 protein results in increased import of Oxaliplatin			[78]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	SLC22A2 protein results in increased susceptibility to Oxaliplatin			[78]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	SLC22A2 protein results in increased uptake of Oxaliplatin			[61]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	tetrahydropalmatine inhibits the reaction SLC22A2 protein results in increased import of Oxaliplatin			[78]
Regulation Mechanism				Transcription Factor Info
oxatomide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	oxatomide inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
oxiconazole	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	oxiconazole inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
oxybutynin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	oxybutynin inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Oxymetazoline	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Oxymetazoline inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Oxymetholone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Oxymetholone inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
p-Aminohippuric Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	p-Aminohippuric Acid inhibits the reaction SLC22A2 protein results in increased uptake of Cimetidine			[55]
Regulation Mechanism				Transcription Factor Info
Paroxetine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Paroxetine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
parthenolide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	parthenolide inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
perfluorodecalin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	perfluorodecalin inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
perfluorohexanesulfonic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid co-treated with perfluorohexanesulfonic acid results in increased expression of SLC22A2 mRNA			[80]
Regulation Mechanism				Transcription Factor Info
perfluorooctane sulfonic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid co-treated with perfluorohexanesulfonic acid results in increased expression of SLC22A2 mRNA			[80]
Regulation Mechanism				Transcription Factor Info
perfluorooctanoic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	perfluorooctanoic acid co-treated with perfluorooctane sulfonic acid co-treated with perfluorohexanesulfonic acid results in increased expression of SLC22A2 mRNA			[80]
Regulation Mechanism				Transcription Factor Info
Pergolide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Pergolide inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Perhexiline	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Perhexiline inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
perospirone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	perospirone inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Perphenazine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Perphenazine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Phenelzine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Phenelzine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Phentolamine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Phentolamine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
phenyltoloxamine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	phenyltoloxamine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Pilocarpine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Pilocarpine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Pioglitazone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Pioglitazone inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Piracetam	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Piracetam inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
pralidoxime	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	pralidoxime inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Praziquantel	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Praziquantel inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Prednisone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Prednisone inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
pridinol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	pridinol inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Primaquine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Primaquine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
prinomastat	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	prinomastat inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Procyclidine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Procyclidine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Promazine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Promazine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Propantheline	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Propantheline inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
proxymetacaine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	proxymetacaine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
pseudoisocyanine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	pseudoisocyanine inhibits the reaction SLC22A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[23]
Regulation Mechanism				Transcription Factor Info
Pyrilamine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Pyrilamine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Pyrimethamine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Pyrimethamine inhibits the reaction SLC22A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[57]
Regulation Mechanism				Transcription Factor Info
Quinidine	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Quinidine inhibits the reaction SLC22A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Quinidine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Rabeprazole	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Rabeprazole inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Raloxifene Hydrochloride	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Raloxifene Hydrochloride inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Selegiline	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Selegiline inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Semustine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Semustine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Sildenafil Citrate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sildenafil Citrate inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
SK&F 550	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SK&F 550 inhibits the reaction SLC22A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[23]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	SK&F 550 results in decreased activity of SLC22A2 protein			[23]
Regulation Mechanism				Transcription Factor Info
Sodium Selenite	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sodium Selenite results in decreased expression of SLC22A2 mRNA			[83]
Regulation Mechanism				Transcription Factor Info
Sparteine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sparteine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Spiperone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Spiperone inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Spironolactone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Spironolactone inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
sulconazole	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	sulconazole inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Tacrine	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tacrine inhibits the reaction SLC22A2 protein polymorphism results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Tacrine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Tegafur	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tegafur inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Telmisartan	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Telmisartan inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Terbutaline	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Terbutaline inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
terconazole	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	terconazole inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
tetrabromobisphenol A	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	tetrabromobisphenol A inhibits the reaction SLC22A2 protein results in increased uptake of Tetraethylammonium			[69]
Regulation Mechanism				Transcription Factor Info
Tetracaine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tetracaine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
tetrahydropalmatine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	tetrahydropalmatine inhibits the reaction SLC22A2 protein results in increased import of Oxaliplatin			[78]
Regulation Mechanism				Transcription Factor Info
tetrahydrozoline	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	tetrahydrozoline inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Thalidomide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Thalidomide inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
thiacloprid	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	thiacloprid metabolite results in decreased activity of SLC22A2 protein			[51]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	thiacloprid results in decreased activity of SLC22A2 protein			[51]
Regulation Mechanism				Transcription Factor Info
Thioridazine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Thioridazine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Tolazoline	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tolazoline inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Tolperisone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tolperisone inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Tolterodine Tartrate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tolterodine Tartrate inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Trazodone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Trazodone inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Tretinoin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tretinoin inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Triamcinolone Acetonide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Triamcinolone Acetonide inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Trihexyphenidyl	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Trihexyphenidyl inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Trimipramine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Trimipramine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Tripelennamine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tripelennamine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Tropisetron	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tropisetron inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
trospium chloride	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	trospium chloride results in decreased activity of SLC22A2 protein			[84]
Regulation Mechanism				Transcription Factor Info
Varenicline	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLC22A2 gene SNP affects the susceptibility to Varenicline			[77]
Regulation Mechanism				Transcription Factor Info
VX-745	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	VX-745 inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
xylometazoline	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	xylometazoline inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
zafirlukast	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	zafirlukast inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Zolpidem	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Zolpidem inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Herbicide
Paraquat	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLC22A2 protein affects the uptake of Paraquat			[79]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	SLC22A2 protein results in increased susceptibility to Paraquat			[79]
Regulation Mechanism				Transcription Factor Info
Approved Drug
Quinine	12 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Quinine inhibits the transportation of N-methylpyridinium by SLC22A2 (IC50 = 8.7 microM)			[1]
Affected Drug/Substrate	N-methylpyridinium	Modulation Type	Inhibition
Cell System	Oocytes-OCT2
DT Modulation2	Quinine inhibits the transportation of N-methylpyridinium by SLC22A2 (IC50 = 23 microM)			[2]
Affected Drug/Substrate	N-methylpyridinium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OCT2
DT Modulation3	Quinine inhibits the transportation of N-methylpyridinium by SLC22A2 (IC50 = 13.3 microM)			[3]
Affected Drug/Substrate	N-methylpyridinium	Modulation Type	Inhibition
Cell System	Chinese hamster ovary (CHO) cells-OCT2
DT Modulation4	Quinine inhibits the transportation of N-methylpyridinium by SLC22A2 (IC50 = 87 microM)			[4]
Affected Drug/Substrate	N-methylpyridinium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OCT2
DT Modulation5	Quinine inhibits the transportation of Tetraethylammonium by SLC22A2 (Ki = 3.4 microM)			[5]
Affected Drug/Substrate	Tetraethylammonium	Modulation Type	Inhibition
Cell System	Oocytes-OCT2
DT Modulation6	Quinine inhibits the transportation of YM155 by SLC22A2 (IC50 = 11 microM)			[6]
Affected Drug/Substrate	YM155	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OCT2
DT Modulation7	Quinine inhibits the activity of SLC22A2			[7]
Cell System	Xenopus laevis oocytes-OCT2
Cimetidine	13 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cimetidine inhibits the transportation of N-methylpyridinium by SLC22A2 (IC50 = 120 microM)			[4]
Affected Drug/Substrate	N-methylpyridinium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OCT2
DT Modulation2	Cimetidine inhibits the transportation of Tetraethylammonium by SLC22A2 (IC50 = 373 microM)			[8]
Affected Drug/Substrate	Tetraethylammonium	Modulation Type	Inhibition
Cell System	Oocytes-OCT2
DT Modulation3	Cimetidine inhibits the transportation of YM155 by SLC22A2 (IC50 = 110 microM)			[6]
Affected Drug/Substrate	YM155	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OCT2
DT Modulation4	Cimetidine inhibits the transportation of 4-(4-(dimethylamino)styryl)-N-methylpyridinium by SLC22A2			[9]
Affected Drug/Substrate	4-(4-(dimethylamino)styryl)-N-methylpyridinium	Modulation Type	Inhibition
DT Modulation5	Cimetidine inhibits the activity of SLC22A2			[10], [11]
Ranitidine	7 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ranitidine inhibits the transportation of Cimetidine by SLC22A2 (Ki = 79 microM)			[12]
Affected Drug/Substrate	Cimetidine	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OCT2
DT Modulation2	Ranitidine inhibits the transportation of Famotidine by SLC22A2 (Ki = 30.5 microM)			[12]
Affected Drug/Substrate	Famotidine	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OCT2
DT Modulation3	Ranitidine inhibits the transportation of N-methylpyridinium by SLC22A2 (IC50 = 76 microM)			[1]
Affected Drug/Substrate	N-methylpyridinium	Modulation Type	Inhibition
Cell System	Oocytes-OCT2
DT Modulation4	Ranitidine inhibits the transportation of N-methylpyridinium by SLC22A2 (IC50 = 1617 microM)			[2]
Affected Drug/Substrate	N-methylpyridinium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OCT2
Metformin	13 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Metformin inhibits the transportation of N-methylpyridinium by SLC22A2 (IC50 = 521 microM)			[1]
Affected Drug/Substrate	N-methylpyridinium	Modulation Type	Inhibition
Cell System	Oocytes-OCT2
DT Modulation2	Metformin inhibits the transportation of N-methylpyridinium by SLC22A2 (IC50 = 398 microM)			[4]
Affected Drug/Substrate	N-methylpyridinium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OCT2
DT Modulation3	Metformin inhibits the transportation of N-methylpyridinium by SLC22A2 (Ki = 289 microM)			[13]
Affected Drug/Substrate	N-methylpyridinium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OCT2
DT Modulation4	Metformin inhibits the transportation of Tetraethylammonium by SLC22A2 (Ki = 1380 microM)			[13]
Affected Drug/Substrate	Tetraethylammonium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OCT2
DT Modulation5	Bisoprolol inhibits the reaction SLC22A2 protein results in increased uptake of Metformin			[58]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Carvedilol inhibits the reaction SLC22A2 protein results in increased uptake of Metformin			[58]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	Metformin inhibits the reaction SLC22A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	Metoprolol inhibits the reaction SLC22A2 protein results in increased uptake of Metformin			[58]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	Ondansetron inhibits the reaction SLC22A2 protein results in increased uptake of Metformin			[75]
Regulation Mechanism				Transcription Factor Info
DT Modulation10	Phenoxybenzamine inhibits the reaction SLC22A2 protein affects the transport of Metformin			[76]
Regulation Mechanism				Transcription Factor Info
DT Modulation11	Propranolol inhibits the reaction SLC22A2 protein results in increased uptake of Metformin			[58]
Regulation Mechanism				Transcription Factor Info
DT Modulation12	SLC22A2 protein affects the transport of Metformin			[76]
Regulation Mechanism				Transcription Factor Info
DT Modulation13	SLC22A2 protein results in increased uptake of Metformin			[58]
Regulation Mechanism				Transcription Factor Info
Clonidine	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Clonidine inhibits the transportation of N-methylpyridinium by SLC22A2 (IC50 = 23 microM)			[2]
Affected Drug/Substrate	N-methylpyridinium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OCT2
DT Modulation2	Clonidine inhibits the transportation of N-methylpyridinium by SLC22A2 (IC50 = 16 microM)			[4]
Affected Drug/Substrate	N-methylpyridinium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OCT2
Diphenhydramine	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Diphenhydramine inhibits the transportation of N-methylpyridinium by SLC22A2 (IC50 = 15 microM)			[2]
Affected Drug/Substrate	N-methylpyridinium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OCT2
DT Modulation2	Diphenhydramine inhibits the transportation of N-methylpyridinium by SLC22A2 (IC50 = 21 microM)			[4]
Affected Drug/Substrate	N-methylpyridinium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OCT2
Amantadine	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Amantadine inhibits the transportation of N-methylpyridinium by SLC22A2 (Ki = 28.4 microM)			[16]
Affected Drug/Substrate	N-methylpyridinium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OCT2
DT Modulation2	Amantadine inhibits the transportation of YM155 by SLC22A2 (IC50 = 45.9 microM)			[6]
Affected Drug/Substrate	YM155	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OCT2
Carvedilol	5 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Carvedilol inhibits the transportation of N-methylpyridinium by SLC22A2 (IC50 = 63 microM)			[4]
Affected Drug/Substrate	N-methylpyridinium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OCT2
DT Modulation2	Carvedilol inhibits the activity of SLC22A2 (IC50 = 3.6 microM)			[17]
Cell System	Human embryonic kidney 293 cells (HEK293)-OCT2
Flurazepam	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Flurazepam inhibits the transportation of N-methylpyridinium by SLC22A2 (IC50 = 60 microM)			[4]
Affected Drug/Substrate	N-methylpyridinium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OCT2
DT Modulation2	Flurazepam inhibits the activity of SLC22A2			[20]
Mexiletine	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Mexiletine inhibits the transportation of N-methylpyridinium by SLC22A2 (IC50 = 55 microM)			[4]
Affected Drug/Substrate	N-methylpyridinium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OCT2
DT Modulation2	Mexiletine inhibits the activity of SLC22A2			[20]
Propranolol	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Propranolol inhibits the transportation of N-methylpyridinium by SLC22A2 (IC50 = 229 microM)			[4]
Affected Drug/Substrate	N-methylpyridinium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OCT2
DT Modulation2	Propranolol inhibits the activity of SLC22A2			[20]
Verapamil	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Verapamil inhibits the transportation of N-methylpyridinium by SLC22A2 (IC50 = 85 microM)			[4]
Affected Drug/Substrate	N-methylpyridinium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OCT2
DT Modulation2	Verapamil inhibits the transportation of YM155 by SLC22A2 (IC50 = 13.4 microM)			[6]
Affected Drug/Substrate	YM155	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OCT2
Procainamide	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Procainamide inhibits the transportation of Tetraethylammonium by SLC22A2 (Ki = 50 microM)			[5]
Affected Drug/Substrate	Tetraethylammonium	Modulation Type	Inhibition
Cell System	Oocytes-OCT2
DT Modulation2	Procainamide inhibits the transportation of YM155 by SLC22A2 (IC50 = 91.9 microM)			[6]
Affected Drug/Substrate	YM155	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OCT2
Telaprevir	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Telaprevir inhibits the activity of SLC22A2 (IC50 = 0.0064 microM)			[18]
DT Modulation2	Telaprevir inhibits the activity of SLC22A2			[22]
Dolutegravir	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Dolutegravir inhibits the transportation of Metformin by SLC22A2			[19]
Affected Drug/Substrate	Metformin	Modulation Type	Inhibition
Cell System	Madin Darby canine kidney strain II (MDCKII) cells-OCT2
DT Modulation2	Dolutegravir inhibits the activity of SLC22A2			[21]
Estradiol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Estradiol inhibits the transportation of 1-Methyl-4-phenylpyridinium by SLC22A2 (IC50 > 30 microM)			[23]
Affected Drug/Substrate	1-Methyl-4-phenylpyridinium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OCT2
Phenoxybenzamine	5 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Phenoxybenzamine inhibits the transportation of 1-Methyl-4-phenylpyridinium by SLC22A2 (IC50 = 4.9 microM)			[23]
Affected Drug/Substrate	1-Methyl-4-phenylpyridinium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OCT2
Progesterone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Progesterone inhibits the transportation of 1-Methyl-4-phenylpyridinium by SLC22A2 (IC50 = 26.7 microM)			[23]
Affected Drug/Substrate	1-Methyl-4-phenylpyridinium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OCT2
Grepafloxacin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Grepafloxacin inhibits the transportation of Creatinine by SLC22A2 (Ki = 10.4 microM)			[24]
Affected Drug/Substrate	Creatinine	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OCT2
Crizotinib	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Crizotinib inhibits the transportation of Creatinine by SLC22A2 (IC50 = 1.58 +/- 0.24 microM)			[25]
Affected Drug/Substrate	Creatinine	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OCT2
Famotidine	5 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Famotidine inhibits the transportation of N-methylpyridinium by SLC22A2 (IC50 = 114 microM)			[1]
Affected Drug/Substrate	N-methylpyridinium	Modulation Type	Inhibition
Cell System	Oocytes-OCT2
Atropine	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Atropine inhibits the transportation of N-methylpyridinium by SLC22A2 (IC50 = 39 microM)			[2]
Affected Drug/Substrate	N-methylpyridinium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OCT2
Butylscopolamine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Butylscopolamine inhibits the transportation of N-methylpyridinium by SLC22A2 (IC50 = 764 microM)			[2]
Affected Drug/Substrate	N-methylpyridinium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OCT2
Cocaine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cocaine inhibits the transportation of N-methylpyridinium by SLC22A2 (Ki = 113 microM)			[16]
Affected Drug/Substrate	N-methylpyridinium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OCT2
Dextroamphetamine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Dextroamphetamine inhibits the transportation of N-methylpyridinium by SLC22A2 (Ki = 10.5 microM)			[16]
Affected Drug/Substrate	N-methylpyridinium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OCT2
Ketamine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ketamine inhibits the transportation of N-methylpyridinium by SLC22A2 (Ki = 22.7 microM)			[16]
Affected Drug/Substrate	N-methylpyridinium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OCT2
Memantine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Memantine inhibits the transportation of N-methylpyridinium by SLC22A2 (Ki = 7.3 microM)			[16]
Affected Drug/Substrate	N-methylpyridinium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OCT2
Pentamidine	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Pentamidine inhibits the transportation of N-methylpyridinium by SLC22A2 (IC50 = 10.6 microM)			[3]
Affected Drug/Substrate	N-methylpyridinium	Modulation Type	Inhibition
Cell System	Chinese hamster ovary (CHO) cells-OCT2
Amitriptyline	6 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Amitriptyline inhibits the transportation of N-methylpyridinium by SLC22A2 (IC50 = 14 microM)			[4]
Affected Drug/Substrate	N-methylpyridinium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OCT2
Chloroquine	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Chloroquine inhibits the transportation of N-methylpyridinium by SLC22A2 (IC50 = 1096 microM)			[4]
Affected Drug/Substrate	N-methylpyridinium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OCT2
Chlorpromazine	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Chlorpromazine inhibits the transportation of N-methylpyridinium by SLC22A2 (IC50 = 14 microM)			[4]
Affected Drug/Substrate	N-methylpyridinium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OCT2
Disopyramide	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Disopyramide inhibits the transportation of N-methylpyridinium by SLC22A2 (IC50 = 324 microM)			[4]
Affected Drug/Substrate	N-methylpyridinium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OCT2
Doxepin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Doxepin inhibits the transportation of N-methylpyridinium by SLC22A2 (IC50 = 13 microM)			[4]
Affected Drug/Substrate	N-methylpyridinium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OCT2
Flecainide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Flecainide inhibits the transportation of N-methylpyridinium by SLC22A2 (IC50 = 191 microM)			[4]
Affected Drug/Substrate	N-methylpyridinium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OCT2
Imipramine	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Imipramine inhibits the transportation of N-methylpyridinium by SLC22A2 (IC50 = 6 microM)			[4]
Affected Drug/Substrate	N-methylpyridinium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OCT2
Mefloquine	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Mefloquine inhibits the transportation of N-methylpyridinium by SLC22A2 (IC50 = 204 microM)			[4]
Affected Drug/Substrate	N-methylpyridinium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OCT2
Propafenone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Propafenone inhibits the transportation of N-methylpyridinium by SLC22A2 (IC50 = 25 microM)			[4]
Affected Drug/Substrate	N-methylpyridinium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OCT2
Sibutramine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sibutramine inhibits the transportation of N-methylpyridinium by SLC22A2 (IC50 = 29 microM)			[4]
Affected Drug/Substrate	N-methylpyridinium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OCT2
Tamoxifen	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tamoxifen inhibits the transportation of N-methylpyridinium by SLC22A2 (IC50 = 87 microM)			[4]
Affected Drug/Substrate	N-methylpyridinium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OCT2
Trimethoprim	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Trimethoprim inhibits the transportation of N-methylpyridinium by SLC22A2 (IC50 = 1318 microM)			[4]
Affected Drug/Substrate	N-methylpyridinium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OCT2
Decitabine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Decitabine inhibits DNA methyltransferase, which then enhances Oxaliplatin's transportation via downregulating the hypermethylation in SLC22A2's promoter			[27]
Affected Drug/Substrate	Oxaliplatin	Modulation Type	Inducer
Cell System	Human renal cell carcinoma cells (RCC)
Vorinostat	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Vorinostat inhibits histone deacetylase, which then enhances Oxaliplatin's transportation via increasing the histone acethylation level of SLC22A2 (IC50 = 4.69 microM)			[28]
Affected Drug/Substrate	Oxaliplatin	Modulation Type	Inducer
Cell System	Human renal cell carcinoma cells (RCC)
Desipramine	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Desipramine inhibits the transportation of Tetraethylammonium by SLC22A2 (IC50 = 16 microM)			[5]
Affected Drug/Substrate	Tetraethylammonium	Modulation Type	Inhibition
Cell System	Oocytes-OCT2
Prazosin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Prazosin inhibits the transportation of YM155 by SLC22A2 (IC50 = 80.4 microM)			[6]
Affected Drug/Substrate	YM155	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OCT2
Testosterone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Testosterone inhibits the activity of SLC22A2 (IC50 = 3 microM)			[33]
Nicotine polacrilex	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Nicotine inhibits the transportation of Tetraethylammonium by SLC22A2			[34]
Affected Drug/Substrate	Tetraethylammonium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OCT2
Vitamin B1	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Vitamin B1 inhibits the transportation of Tetraethylammonium by SLC22A2			[34]
Affected Drug/Substrate	Tetraethylammonium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OCT2
Cetirizine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cetirizine inhibits the transportation of Tetraethylammonium by SLC22A2			[35]
Affected Drug/Substrate	Tetraethylammonium	Modulation Type	Inhibition
Cell System	Oocytes-OCT2
Pilsicainide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Pilsicainide inhibits the transportation of Tetraethylammonium by SLC22A2			[35]
Affected Drug/Substrate	Tetraethylammonium	Modulation Type	Inhibition
Cell System	Oocytes-OCT2
Quercetin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Quercetin induces the transportation of Tetraethylammonium by SLC22A2			[36]
Affected Drug/Substrate	Tetraethylammonium	Modulation Type	Inhibition
Cell System	Human enterocyte-like 2 cell (Caco-2); LLC-PK1 vesicles
Metoprolol	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Metoprolol inhibits the transportation of Cimetidine by SLC22A2			[38]
Affected Drug/Substrate	Cimetidine	Modulation Type	Inhibition
Oxprenolol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Oxprenolol inhibits the transportation of Cimetidine by SLC22A2			[38]
Affected Drug/Substrate	Cimetidine	Modulation Type	Inhibition
Indomethacin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Indomethacin inhibits the activity of SLC22A2			[39]
Naproxen	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Naproxen inhibits the activity of SLC22A2			[39]
Piroxicam	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Piroxicam inhibits the activity of SLC22A2			[39]
Sulindac	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sulindac inhibits the activity of SLC22A2			[39]
Valproic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Valproic Acid affects the expression of SLC22A2			[40]
Cisplatin	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cisplatin inhibits the activity of SLC22A2			[41], [42]
Dexamethasone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Dexamethasone induces the activity of SLC22A2			[43]
Budesonide	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Budesonide inhibits the activity of SLC22A2			[44]
Plazomicin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Plazomicin inhibits the activity of SLC22A2			[45]
Vancomycin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Vancomycin inhibits the activity of SLC22A2			[46]
Itraconazole	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Itraconazole inhibits the activity of SLC22A2			[47]
Ketoconazole	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ketoconazole inhibits the activity of SLC22A2			[47]
Triazolam	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Triazolam inhibits the activity of SLC22A2			[30]
Diazepam	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Diazepam inhibits the activity of SLC22A2			[30]
Haloperidol	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Haloperidol inhibits the activity of SLC22A2			[30]
Lidocaine	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Lidocaine inhibits the activity of SLC22A2			[30]
Malathion	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Malathion inhibits the activity of SLC22A2			[30]
Mianserin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Mianserin inhibits the activity of SLC22A2			[30]
Aspirin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLC22A2 polymorphism affects the susceptibility to Aspirin			[65]
Regulation Mechanism				Transcription Factor Info
Drug in Phase 4 Trial
Pyridine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Pyridine inhibits the transportation of Tetraethylammonium by SLC22A2 (IC50 = 790 microM)			[29]
Affected Drug/Substrate	Tetraethylammonium	Modulation Type	Inhibition
Cell System	Chinese hamster ovary (CHO) cells-OCT2
Drug in Phase 2 Trial
YM155	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	YM155 inhibits the transportation of N-methylpyridinium by SLC22A2 (IC50 = 15.9 microM)			[6]
Affected Drug/Substrate	N-methylpyridinium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OCT2
Genistein	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Genistein induces the transportation of Tetraethylammonium by SLC22A2			[36]
Affected Drug/Substrate	Tetraethylammonium	Modulation Type	Inhibition
Cell System	Human enterocyte-like 2 cell (Caco-2); LLC-PK1 vesicles
MeIQx	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	MeIQx inhibits the activity of SLC22A2			[50]
Drug in Phase 1 Trial
Naringenin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Naringenin induces the transportation of Tetraethylammonium by SLC22A2			[36]
Affected Drug/Substrate	Tetraethylammonium	Modulation Type	Inhibition
Cell System	Human enterocyte-like 2 cell (Caco-2); LLC-PK1 vesicles
Drug in Preclinical Test
N-methylpyridinium	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	N-methylpyridinium inhibits the transportation of Tetraethylammonium by SLC22A2 (Ki = 2.4 microM)			[5]
Affected Drug/Substrate	Tetraethylammonium	Modulation Type	Inhibition
Cell System	Oocytes-OCT2
DT Modulation2	N-methylpyridinium inhibits the transportation of YM155 by SLC22A2 (IC50 = 4.42 microM)			[6]
Affected Drug/Substrate	YM155	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OCT2
Beta-carboline	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Beta-carboline inhibits the activity of SLC22A2			[50]
Discontinued Drug
DX-619	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	DX-619 inhibits the transportation of Creatinine by SLC22A2 (Ki = 0.94 microM)			[24]
Affected Drug/Substrate	Creatinine	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OCT2
Dizocilpine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Dizocilpine inhibits the transportation of N-methylpyridinium by SLC22A2 (Ki = 21.5 microM)			[16]
Affected Drug/Substrate	N-methylpyridinium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OCT2
Antiparasitics	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Antiparasitics inhibits the transportation of N-methylpyridinium by SLC22A2 (IC50 = 182 microM)			[3]
Affected Drug/Substrate	N-methylpyridinium	Modulation Type	Inhibition
Cell System	Chinese hamster ovary (CHO) cells-OCT2
Acecainide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Acecainide inhibits the transportation of Tetraethylammonium by SLC22A2			[34]
Affected Drug/Substrate	Tetraethylammonium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OCT2
Investigative Drug
Tetraethylammonium	30 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tetraethylammonium inhibits the transportation of N-methylpyridinium by SLC22A2 (IC50 = 222 microM)			[1]
Affected Drug/Substrate	N-methylpyridinium	Modulation Type	Inhibition
Cell System	Oocytes-OCT2
DT Modulation2	Tetraethylammonium inhibits the transportation of N-methylpyridinium by SLC22A2 (IC50 = 189.2 microM)			[3]
Affected Drug/Substrate	N-methylpyridinium	Modulation Type	Inhibition
Cell System	Chinese hamster ovary (CHO) cells-OCT2
Decynium 22	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Decynium 22 inhibits the transportation of Tetraethylammonium by SLC22A2 (IC50 = 13.8 microM)			[8]
Affected Drug/Substrate	Tetraethylammonium	Modulation Type	Inhibition
Cell System	Oocytes-OCT2
DT Modulation2	Decynium 22 inhibits the transportation of Tetraethylammonium by SLC22A2 (Ki = 0.1 microM)			[5]
Affected Drug/Substrate	Tetraethylammonium	Modulation Type	Inhibition
Cell System	Oocytes-OCT2
Phencyclidine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Phencyclidine inhibits the transportation of N-methylpyridinium by SLC22A2 (Ki = 24.9 microM)			[16]
Affected Drug/Substrate	N-methylpyridinium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OCT2
Corticosterone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Corticosterone inhibits the transportation of YM155 by SLC22A2 (IC50 = 5.35 microM)			[6]
Affected Drug/Substrate	YM155	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OCT2
Monocrotaline	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Monocrotaline inhibits the activity of SLC22A2 (IC50 = 1800 microM)			[53]
Cell System	Human embryonic kidney 293 cells (HEK293)
Patented Pharmaceutical Agent
GSK-J4	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	GSK-J4 increases the expression of SLC22A2			[49]
Drug Withdrawn
Phenformin	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Phenformin inhibits the transportation of N-methylpyridinium by SLC22A2 (Ki = 54 microM)			[13]
Affected Drug/Substrate	N-methylpyridinium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OCT2
DT Modulation2	Phenformin inhibits the transportation of Tetraethylammonium by SLC22A2 (Ki = 111 microM)			[13]
Affected Drug/Substrate	Tetraethylammonium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OCT2
Etilefrine	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Etilefrine inhibits the transportation of N-methylpyridinium by SLC22A2 (IC50 = 4009 microM)			[2]
Affected Drug/Substrate	N-methylpyridinium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OCT2
Fenfluramine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Fenfluramine inhibits the transportation of N-methylpyridinium by SLC22A2 (IC50 = 10 microM)			[4]
Affected Drug/Substrate	N-methylpyridinium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OCT2
valdecoxib	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	valdecoxib inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Natural Product
Fenamiphos	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Fenamiphos inhibits the transportation of Dopamine by SLC22A2 (IC50 = 2.8 microM)			[14]
Affected Drug/Substrate	Dopamine	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OCT2
DT Modulation2	Fenamiphos inhibits the transportation of Rhodamine 123 by SLC22A2 (IC50 = 6.9 microM)			[14]
Affected Drug/Substrate	Rhodamine 123	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OCT2
Phosmet	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Phosmet inhibits the transportation of Dopamine by SLC22A2 (IC50 = 3.6 microM)			[14]
Affected Drug/Substrate	Dopamine	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OCT2
DT Modulation2	Phosmet inhibits the transportation of Rhodamine 123 by SLC22A2 (IC50 = 7.9 microM)			[14]
Affected Drug/Substrate	Rhodamine 123	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OCT2
Piperine	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Piperine inhibits the transportation of Metformin by SLC22A2 (IC50 = 3.727 microM)			[15]
Affected Drug/Substrate	Metformin	Modulation Type	Inhibition
Cell System	Madin darby canine kidney strain cell line (MDCK)-OCT2
DT Modulation2	Piperine inhibits the transportation of Serotonin by SLC22A2 (IC50 = 5.4 microM)			[15]
Affected Drug/Substrate	Serotonin	Modulation Type	Inhibition
Cell System	Madin darby canine kidney strain cell line (MDCK)-OCT2
Citreoverdine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Citreoverdine inhibits the transportation of Organic cation by SLC22A2 (IC50 = 17.7 microM)			[26]
Affected Drug/Substrate	Organic cation	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OCT2
Allethrin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Allethrin inhibits the transportation of Verapamil by SLC22A2 (IC50 = 42.6 microM)			[31]
Affected Drug/Substrate	Verapamil	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OCT2
Tetramethrin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tetramethrin inhibits the transportation of Verapamil by SLC22A2 (IC50 = 11.2 microM)			[31]
Affected Drug/Substrate	Verapamil	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OCT2
Cigarette smoke condensate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cigarette smoke condensate inhibits the activity of SLC22A2 (IC50 = 12.5 microM)			[32]
Cell System	Human embryonic kidney 293 cells (HEK293)-OCT2
Green tea	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Green tea inhibits the transportation of Metformin by SLC22A2			[37]
Affected Drug/Substrate	Metformin	Modulation Type	Inhibition
Cell System	Human enterocyte-like 2 cell (Caco-2)-OCT2
Tobacco Smoke Pollution	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tobacco Smoke Pollution inhibits the activity of SLC22A2			[32]
Chlorpyrifos	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Chlorpyrifos inhibits the activity of SLC22A2			[30]
Rhein	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Rhein up-regulated the expressions of SLC22A2			[54]
Cell System	NRK-52E cells
Resveratrol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Plant Extracts co-treated with Resveratrol results in decreased expression of SLC22A2 mRNA			[82]
Regulation Mechanism				Transcription Factor Info
Biotoxin
Aconitine	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Aconitine inhibits the transportation of Tetraethylammonium by SLC22A2 (IC50 = 59.2 microM)			[30]
Affected Drug/Substrate	Tetraethylammonium	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OCT2
Environmental toxicant
Fenitrothion	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Fenitrothion inhibits the activity of SLC22A2			[30]
Mycotoxins
Aflatoxin B1	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Aflatoxin B1 inhibits the transportation of Organic cation by SLC22A2 (IC50 = 121 microM)			[26]
Affected Drug/Substrate	Organic cation	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OCT2
DT Modulation2	Aflatoxin B1 results in increased methylation of SLC22A2 gene			[64]
Regulation Mechanism				Transcription Factor Info
Alpha-zearalenol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Alpha-zearalenol inhibits the transportation of Organic cation by SLC22A2 (IC50 = 34.3 microM)			[26]
Affected Drug/Substrate	Organic cation	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OCT2
Citrioveridine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Citrioveridine inhibits the transportation of Organic cation by SLC22A2 (IC50 = 17.7 microM)			[26]
Affected Drug/Substrate	Organic cation	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OCT2
Cyclopiazonic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cyclopiazonic acid inhibits the transportation of Organic cation by SLC22A2 (IC50 > 1000 microM)			[26]
Affected Drug/Substrate	Organic cation	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OCT2
Fumonisin B1	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Fumonisin B1 inhibits the transportation of Organic cation by SLC22A2			[26]
Affected Drug/Substrate	Organic cation	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OCT2
Patulin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Patulin inhibits the transportation of Organic cation by SLC22A2 (IC50 > 1000 microM)			[26]
Affected Drug/Substrate	Organic cation	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OCT2
Gliotoxin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Gliotoxin inhibits the transportation of Organic cation by SLC22A2 (IC50 = 117 microM)			[26]
Affected Drug/Substrate	Organic cation	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OCT2
Zearalenone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Zearalenone inhibits the transportation of Organic cation by SLC22A2 (IC50 = 24.8 microM)			[26]
Affected Drug/Substrate	Organic cation	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OCT2
Acute Toxic Substance
Mercuric Chloride	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Mercuric Chloride inhibits the activity of SLC22A2			[48]
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine inhibits the activity of SLC22A2			[50]
Strychnine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Strychnine inhibits the reaction SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[9]
Regulation Mechanism				Transcription Factor Info
Carcinogen
2-amino-3-methylimidazo(4,5-f)quinoline	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	2-amino-3-methylimidazo(4,5-f)quinoline inhibits the activity of SLC22A2			[50]
Benzo(a)pyrene	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Benzo(a)pyrene inhibits the expression of SLC22A2			[52]
Pesticide/Insecticide
DT Modulation1	Malathion inhibits the reaction SLC22A2 protein results in increased uptake of Tetraethylammonium			[30]
Regulation Mechanism				Transcription Factor Info
Clothianidin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Clothianidin inhibits the activity of SLC22A2			[51]
Imidacloprid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Imidacloprid inhibits the activity of SLC22A2			[51]
Thiamethoxam	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Thiamethoxam inhibits the activity of SLC22A2			[51]
DT Modulation1	Chlorpyrifos inhibits the reaction SLC22A2 protein results in increased uptake of Tetraethylammonium			[30]
Regulation Mechanism				Transcription Factor Info
imidacloprid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	imidacloprid results in decreased activity of SLC22A2 protein			[51]
Regulation Mechanism				Transcription Factor Info

References
1	Differential substrate and inhibitory activities of ranitidine and famotidine toward human organic cation transporter 1 (hOCT1; SLC22A1), hOCT2 (SLC22A2), and hOCT3 (SLC22A3). J Pharmacol Exp Ther. 2005 Dec;315(3):1288-97.
2	Drug specificity and intestinal membrane localization of human organic cation transporters (OCT). Biochem Pharmacol. 2005 Dec 5;70(12):1851-60.
3	Transport of dicationic drugs pentamidine and furamidine by human organic cation transporters. Drug Metab Dispos. 2009 Feb;37(2):424-30.
4	Structural determinants of inhibitor interaction with the human organic cation transporter OCT2 (SLC22A2). Naunyn Schmiedebergs Arch Pharmacol. 2009 Apr;379(4):337-48.
5	Cloning and characterization of two human polyspecific organic cation transporters. DNA Cell Biol. 1997 Jul;16(7):871-81.
6	Characterization of human organic cation transporter 1 (OCT1/SLC22A1)- and OCT2 (SLC22A2)-mediated transport of 1-(2-methoxyethyl)-2-methyl-4,9-dioxo-3-(pyrazin-2-ylmethyl)- 4,9-dihydro-1H-naphtho[2,3-d]imidazolium bromide (YM155 monobromide), a novel small molecule survivin suppressant. Drug Metab Dispos. 2010 Jan;38(1):1-4.
7	Ventricular choline transport: a role for organic cation transporter 2 expressed in choroid plexus. J Biol Chem. 2001 Nov 9;276(45):41611-9.
8	Molecular mechanisms of organic cation transport in OCT2-expressing Xenopus oocytes. Biochim Biophys Acta. 1999 Mar 4;1417(2):224-31.
9	Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2. J Med Chem. 2011 Jul 14;54(13):4548-58.
10	Elevated systemic elimination of cimetidine in rats with acute biliary obstruction: the role of renal organic cation transporter OCT2. Drug Metab Pharmacokinet. 2010;25(4):328-34.
11	The human organic cation transporter (hOCT2) recognizes the degree of substrate ionization. J Biol Chem. 2002 Jun 21;277(25):22491-6.
12	A species difference in the transport activities of H2 receptor antagonists by rat and human renal organic anion and cation transporters. J Pharmacol Exp Ther. 2005 Oct;315(1):337-45.
13	Comparison of the kinetic characteristics of inhibitory effects exerted by biguanides and H2-blockers on human and rat organic cation transporter-mediated transport: Insight into the development of drug candidates. Xenobiotica. 2007 Jun;37(6):618-34.
14	Interactions of organophosphorus pesticides with solute carrier (SLC) drug transporters. Xenobiotica. 2019 Mar;49(3):363-374.
15	Involvement of organic cation transporter 2 inhibition in potential mechanisms of antidepressant action. Prog Neuropsychopharmacol Biol Psychiatry. 2014 Aug 4;53:90-8.
16	Differential pharmacological in vitro properties of organic cation transporters and regional distribution in rat brain. Neuropharmacology. 2006 Jun;50(8):941-52.
17	Selective Inhibition on Organic Cation Transporters by Carvedilol Protects Mice from Cisplatin-Induced Nephrotoxicity. Pharm Res. 2018 Sep 6;35(11):204.
18	Drug interactions and protease inhibitors used in the treatment of hepatitis C: how to manage? Eur J Clin Pharmacol. 2014 Jul;70(7):775-89.
19	In vitro investigations into the roles of drug transporters and metabolizing enzymes in the disposition and drug interactions of dolutegravir, a HIV integrase inhibitor. Drug Metab Dispos. 2013 Feb;41(2):353-61.
20	Functional characterization of the human organic cation transporter 2 variant p.270Ala>Ser. Drug Metab Dispos. 2009 Jun;37(6):1312-8.
21	Raltegravir has a low propensity to cause clinical drug interactions through inhibition of major drug transporters: an in vitro evaluation. Antimicrob Agents Chemother. 2014;58(3):1294-301.
22	eGFR decrease during antiviral C therapy with first generation protease inhibitors: a clinical significance? Liver Int. 2015 Jan;35(1):71-8.
23	Expression and pharmacological profile of the human organic cation transporters hOCT1, hOCT2 and hOCT3. Br J Pharmacol. 2002 Jul;136(6):829-36.
24	Prediction of fluoroquinolone-induced elevation in serum creatinine levels: a case of drug-endogenous substance interaction involving the inhibition of renal secretion. Clin Pharmacol Ther. 2011 Jan;89(1):81-8.
25	Inhibitory Effect of Crizotinib on Creatinine Uptake by Renal Secretory Transporter OCT2. J Pharm Sci. 2017 Sep;106(9):2899-2903.
26	Interactions of organic anion transporters and organic cation transporters with mycotoxins. J Pharmacol Sci. 2008 Mar;106(3):435-43.
27	Epigenetic activation of the drug transporter OCT2 sensitizes renal cell carcinoma to oxaliplatin. Sci Transl Med. 2016 Jul 20;8(348):348ra97.
28	Regulation of OCT2 transcriptional repression by histone acetylation in renal cell carcinoma. Epigenetics. 2019 May 15:1-13.
29	Characterization of the inhibitory effects of N-butylpyridinium chloride and structurally related ionic liquids on organic cation transporters 1/2 and human toxic extrusion transporters 1/2-k in vitro and in vivo. Drug Metab Dispos. 2011 Sep;39(9):1755-61.
30	Human organic cation transporter 2 (hOCT2): Inhibitor studies using S2-hOCT2 cells. Toxicology. 2013 Aug 9;310:98-103.
31	Inhibition of Human Drug Transporter Activities by the Pyrethroid Pesticides Allethrin and Tetramethrin. PLoS One. 2017 Jan 18;12(1):e0169480.
32	Inhibition of organic anion transporter (OAT) activity by cigarette smoke condensate. Toxicol In Vitro. 2017 Oct;44:27-35.
33	Polyspecific organic cation transporters: structure, function, physiological roles, and biopharmaceutical implications. Pharm Res. 2007 Jul;24(7):1227-51.
34	cDNA cloning, functional characterization, and tissue distribution of an alternatively spliced variant of organic cation transporter hOCT2 predominantly expressed in the human kidney. J Am Soc Nephrol. 2002 Jul;13(7):1703-10.
35	Severe arrhythmia as a result of the interaction of cetirizine and pilsicainide in a patient with renal insufficiency: first case presentation showing competition for excretion via renal multidrug resistance protein 1 and organic cation transporter 2. Clin Pharmacol Ther. 2006 Apr;79(4):389-96.
36	Effects of dietary flavonoids on the transport of cimetidine via P-glycoprotein and cationic transporters in Caco-2 and LLC-PK1 cell models. Xenobiotica. 2008 Dec;38(12):1536-50.
37	Inhibitory Effects of Green Tea and (-)-Epigallocatechin Gallate on Transport by OATP1B1, OATP1B3, OCT1, OCT2, MATE1, MATE2-K and P-Glycoprotein. PLoS One. 2015 Oct 1;10(10):e0139370.
38	The organic cation transporter OCT2 mediates the uptake of beta-adrenoceptor antagonists across the apical membrane of renal LLC-PK(1) cell monolayers. Br J Pharmacol. 2000 Sep;131(1):71-9.
39	Interactions of human organic anion transporters and human organic cation transporters with nonsteroidal anti-inflammatory drugs. J Pharmacol Exp Ther. 2002 Nov;303(2):534-9.
40	Gene Expression Regulation and Pathway Analysis After Valproic Acid and Carbamazepine Exposure in a Human Embryonic Stem Cell-Based Neurodevelopmental Toxicity Assay. Toxicol Sci. 2015 Aug;146(2):311-20.
41	Cisplatin nephrotoxicity is critically mediated via the human organic cation transporter 2. Am J Pathol. 2005 Dec;167(6):1477-84.
42	Organic cation transporter OCT/SLC22A and H(+)/organic cation antiporter MATE/SLC47A are key molecules for nephrotoxicity of platinum agents. Biochem Pharmacol. 2011 Mar 1;81(5):563-8.
43	Functional characteristics and steroid hormone-mediated regulation of an organic cation transporter in Madin-Darby canine kidney cells. J Pharmacol Exp Ther. 2001 Oct;299(1):392-8.
44	Polyspecific cation transporters mediate luminal release of acetylcholine from bronchial epithelium. Am J Respir Cell Mol Biol. 2005 Jul;33(1):79-88.
45	No Effect of Plazomicin on the Pharmacokinetics of Metformin in Healthy Subjects. Clin Pharmacol Drug Dev. 2019 Jan 3.
46	JBP485 attenuates vancomycin-induced nephrotoxicity by regulating the expressions of organic anion transporter (Oat) 1, Oat3, organic cation transporter 2 (Oct2), multidrug resistance-associated protein 2 (Mrp2) and P-glycoprotein (P-gp) in rats. Toxicol Lett. 2018 Oct 1;295:195-204.
47	Evaluation of Ketoconazole and Its Alternative Clinical CYP3A4/5 Inhibitors as Inhibitors of Drug Transporters: The In Vitro Effects of Ketoconazole, Ritonavir, Clarithromycin, and Itraconazole on 13 Clinically-Relevant Drug Transporters. Drug Metab Dispos. 2016 Mar;44(3):453-9.
48	Inorganic mercury interacts with cysteine residues (C451 and C474) of hOCT2 to reduce its transport activity. Am J Physiol Renal Physiol. 2007 May;292(5):F1583-91.
49	Inhibition of histone H3K27 demethylases selectively modulates inflammatory phenotypes of natural killer cells. J Biol Chem. 2018 Feb 16;293(7):2422-2437.
50	Inhibition of organic cation transporter (OCT) activities by carcinogenic heterocyclic aromatic amines. Toxicol In Vitro. 2019 Feb;54:10-22.
51	Neonicotinoid pesticides poorly interact with human drug transporters. J Biochem Mol Toxicol. 2019 Oct;33(10):e22379.
52	Identification of a transcriptomic signature of food-relevant genotoxins in human HepaRG hepatocarcinoma cells. Food Chem Toxicol. 2020 Jun;140:111297.
53	An in vitro study on interaction of anisodine and monocrotaline with organic cation transporters of the SLC22 and SLC47 families. Chin J Nat Med. 2019 Jul;17(7):490-497.
54	Protective effect of Rhein against vancomycin-induced nephrotoxicity through regulating renal transporters and Nrf2 pathway. Phytother Res. 2022 Nov;36(11):4244-4262.
55	Different transport properties between famotidine and cimetidine by human renal organic ion transporters (SLC22A). Eur J Pharmacol. 2004 Oct 25;503(1-3):25-30.
56	Organic cation transporters OCT1, 2, and 3 mediate high-affinity transport of the mutagenic vital dye ethidium in the kidney proximal tubule. Am J Physiol Renal Physiol. 2009;296(6):F1504-13.
57	Expression of Organic Anion Transporting Polypeptide 1A2 in Red Blood Cells and Its Potential Impact on Antimalarial Therapy. Drug Metab Dispos. 2016;44(10):1562-8.
58	Interaction of beta-blockers with the renal uptake transporter OCT2. Diabetes Obes Metab. 2009;11(11):1080-3.
59	Identification and functional characterization of genetic variants of human organic cation transporters in a Korean population. Drug Metab Dispos. 2007;35(4):667-75.
60	Are organic cation transporters capable of transporting prostaglandins? Naunyn Schmiedebergs Arch Pharmacol. 2005 Aug;372(2):125-30.
61	Interaction of the chemotherapeutic agent oxaliplatin and the tyrosine kinase inhibitor dasatinib with the organic cation transporter 2. Arch Toxicol. 2024 Jul;98(7):2131-2142.
62	In Vitro Interaction of AB-FUBINACA with Human Cytochrome P450, UDP-Glucuronosyltransferase Enzymes and Drug Transporters. Molecules. 2020;25(19).
63	Integration of transcriptomics, proteomics and metabolomics data to reveal the biological mechanisms of abrin injury in human lung epithelial cells. Toxicol Lett. 2019;312:1-10.
64	Aflatoxin B1 induces persistent epigenomic effects in primary human hepatocytes associated with hepatocellular carcinoma. Toxicology. 2016 Mar 28;350-352:31-9.
65	Possible association of SLC22A2 polymorphisms with aspirin-intolerant asthma. Int Arch Allergy Immunol. 2011;155(4):395-402.
66	Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017;8(1):1369-1391.
67	Exome-wide mutation profile in benzo[a]pyrene-derived post-stasis and immortal human mammary epithelial cells. Mutat Res Genet Toxicol Environ Mutagen. 2014;775-776:48-54.
68	DNA methylome-wide alterations associated with estrogen receptor-dependent effects of bisphenols in breast cancer. Clin Epigenetics. 2019;11(1):138.
69	Inhibition of SLC drug transporter activities by environmental bisphenols. Toxicol In Vitro. 2017 Apr;40:34-44.
70	Identification of potential target genes of ROR-alpha in THP1 and HUVEC cell lines. Exp Cell Res. 2017;353(1):6-15.
71	Ameliorative effects of SLC22A2 gene polymorphism 808 G/T and cimetidine on cisplatin-induced nephrotoxicity in Chinese cancer patients. Food Chem Toxicol. 2012;50(7):2289-93.
72	Organic Cation Transporter 2 Overexpression May Confer an Increased Risk of Gentamicin-Induced Nephrotoxicity. Antimicrob Agents Chemother. 2016;60(9):5573-80.
73	Transport of lamivudine [(-)-beta-L-2',3'-dideoxy-3'-thiacytidine] and high-affinity interaction of nucleoside reverse transcriptase inhibitors with human organic cation transporters 1, 2, and 3. J Pharmacol Exp Ther. 2009;329(1):252-61.
74	Integrated miRNA and mRNA omics reveal the anti-cancerous mechanism of Licochalcone B on Human Hepatoma Cell HepG2. Food Chem Toxicol. 2021;150:112096.
75	Ondansetron can enhance cisplatin-induced nephrotoxicity via inhibition of multiple toxin and extrusion proteins (MATEs). Toxicol Appl Pharmacol. 2013;273(1):100-9.
76	Genetic variants of organic cation transporter 2 (OCT2) significantly reduce metformin uptake in oocytes. Xenobiotica. 2008;38(9):1252-62.
77	Organic cation transporter variation and response to smoking cessation therapies. Nicotine Tob Res. 2014;16(12):1638-46.
78	L-tetrahydropalmatine reduces oxaliplatin accumulation in the dorsal root ganglion and mitochondria through selectively inhibiting the transporter-mediated uptake thereby attenuates peripheral neurotoxicity. Toxicology. 2021;459:152853.
79	Transport of paraquat by human organic cation transporters and multidrug and toxic compound extrusion family. J Pharmacol Exp Ther. 2007;322(2):695-700.
80	An environmentally relevant mixture of per- and polyfluoroalkyl substances (PFAS) impacts proliferation, steroid hormone synthesis, and gene transcription in primary human granulosa cells. Toxicol Sci. 2024;200(1):57-69.
81	Involvement of aryl hydrocarbon receptor in the cytotoxicity of corannulene and its derivatives. Toxicol Lett. 2020 Mar 15;321:114-121.
82	One-year supplementation with a grape extract containing resveratrol modulates inflammatory-related microRNAs and cytokines expression in peripheral blood mononuclear cells of type 2 diabetes and hypertensive patients with coronary artery disease. Pharmacol Res. 2013;72:69-82.
83	Supplementation of healthy volunteers with nutritionally relevant amounts of selenium increases the expression of lymphocyte protein biosynthesis genes. Am J Clin Nutr. 2008;87(1):181-9.
84	Expression of drug transporters and drug metabolizing enzymes in the bladder urothelium in man and affinity of the bladder spasmolytic trospium chloride to transporters likely involved in its pharmacokinetics. Mol Pharm. 2015 Jan 5;12(1):171-8.

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