Detail Information of Exogenous Modulation

General Information of Drug Transporter (DT)
DT ID	DTD0002 Transporter Info
Gene Name	ABCC2
Transporter Name	Multidrug resistance-associated protein 2
Gene ID	1244
UniProt ID	Q92887

Exogenous factors (drugs, dietary constituents, etc.) Modulation of This DT (EGM)
Approved Drug
Cyclosporine	6 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cyclosporine inhibits the transportation of Calcein AM by ABCC2 (IC50 = 10 microM)			[1]
Affected Drug/Substrate	Calcein AM	Modulation Type	Inhibition
Cell System	Madin Darby canine kidney strain II (MDCKII) cells-MRP2
DT Modulation2	Cyclosporine inhibits the transportation of Leukotriene C4 by ABCC2 (Ki = 4.7 microM)			[2]
Affected Drug/Substrate	Leukotriene C4	Modulation Type	Inhibition
Cell System	LLC-PK1 vesicles-MRP2
DT Modulation3	Cyclosporine inhibits the transportation of Monoglucuronosyl bilirubin by ABCC2 (Ki = 21 microM)			[3]
Affected Drug/Substrate	Monoglucuronosyl bilirubin	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MRP2
DT Modulation4	Cyclosporine inhibits the transportation of Vinblastine by ABCC2 (Ki = 8.11 microM)			[4]
Affected Drug/Substrate	Vinblastine	Modulation Type	Inhibition
Cell System	Madin Darby canine kidney strain II (MDCKII) cells-MRP2
DT Modulation5	Cyclosporine inhibits the transportation of Calcein AM by ABCC2			[5]
Affected Drug/Substrate	Calcein AM	Modulation Type	Inhibition
Cell System	Madin Darby canine kidney strain II (MDCKII) cells-MRP2
DT Modulation6	Cyclosporine inhibits the activity of ABCC2			[6], [7]
Vinblastine	6 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Vinblastine inhibits the transportation of Calcein AM by ABCC2 (IC50 = 21 microM)			[12]
Affected Drug/Substrate	Calcein AM	Modulation Type	Inhibition
Cell System	Madin-Darby Canine Kidney (MDCK) cells-MRP2
DT Modulation2	Vinblastine inhibits the activity of ABCC2			[14], [15]
Indomethacin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Indomethacin inhibits the transportation of Methotrexate by ABCC2 (IC50 = 0.06 microM)			[13]
Affected Drug/Substrate	Methotrexate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MRP2
DT Modulation2	Indomethacin inhibits the activity of ABCC2			[16], [17]
Bosentan	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Bosentan inhibits the transportation of Estradiol 17b-D-glucuronide by ABCC2			[19]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Probenecid	12 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Probenecid inhibits the transportation of SN-38 by ABCC2			[20]
Affected Drug/Substrate	SN-38	Modulation Type	Inhibition
DT Modulation2	Probenecid inhibits the activity of ABCC2			[24], [25]
Cisplatin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cisplatin induces the activity of ABCC2			[21]
Cell System	Human hepatocellular carcinoma cell line (HepG2)-MRP2
Ritonavir	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ritonavir inhibits the activity of ABCC2			[22], [23]
Dexamethasone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Dexamethasone induces the activity of ABCC2			[26]
Simvastatin	6 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Simvastatin inhibits the transportation of Calcein AM by ABCC2 (IC50 = 25 +/- 2 microM)			[12]
Affected Drug/Substrate	Calcein AM	Modulation Type	Inhibition
Cell System	Madin-Darby Canine Kidney (MDCK) cells-MRP2
Gemifloxacin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Gemifloxacin inhibits the transportation of Erythromycin by ABCC2 (IC50 = 16 microM)			[27]
Affected Drug/Substrate	Erythromycin	Modulation Type	Inhibition
Cell System	Madin Darby canine kidney strain II (MDCKII) cells-MRP2
Ketoprofen	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ketoprofen inhibits the transportation of Methotrexate by ABCC2 (IC50 = 1.4 microM)			[13]
Affected Drug/Substrate	Methotrexate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MRP2
Daunorubicin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Daunorubicin inhibits the transportation of Vinblastine by ABCC2 (Ki = 49.4 microM)			[4]
Affected Drug/Substrate	Vinblastine	Modulation Type	Inhibition
Cell System	Madin Darby canine kidney strain II (MDCKII) cells-MRP2
Etoposide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Etoposide inhibits the transportation of Vinblastine by ABCC2 (Ki = 756 microM)			[4]
Affected Drug/Substrate	Vinblastine	Modulation Type	Inhibition
Cell System	Madin Darby canine kidney strain II (MDCKII) cells-MRP2
Reserpine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Reserpine inhibits the transportation of Vinblastine by ABCC2 (Ki = 295 microM)			[4]
Affected Drug/Substrate	Vinblastine	Modulation Type	Inhibition
Cell System	Madin Darby canine kidney strain II (MDCKII) cells-MRP2
Vincristine	8 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Vincristine inhibits the transportation of Vinblastine by ABCC2 (Ki = 802 microM)			[4]
Affected Drug/Substrate	Vinblastine	Modulation Type	Inhibition
Cell System	Madin Darby canine kidney strain II (MDCKII) cells-MRP2
Canagliflozin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Canagliflozin inhibits the activity of ABCC2 (IC50 = 19.3 microM)			[30]
Delavirdine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Delavirdine inhibits the transportation of 5-Chloromethylfluorescein diacetate by ABCC2			[31]
Affected Drug/Substrate	5-Chloromethylfluorescein diacetate	Modulation Type	Inhibition
Cell System	Madin Darby canine kidney strain II (MDCKII) cells-MRP2
Efavirenz	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Efavirenz inhibits the transportation of 5-Chloromethylfluorescein diacetate by ABCC2			[31]
Affected Drug/Substrate	5-Chloromethylfluorescein diacetate	Modulation Type	Inhibition
Cell System	Madin Darby canine kidney strain II (MDCKII) cells-MRP2
Emtricitabine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Emtricitabine inhibits the transportation of 5-Chloromethylfluorescein diacetate by ABCC2			[31]
Affected Drug/Substrate	5-Chloromethylfluorescein diacetate	Modulation Type	Inhibition
Cell System	Madin Darby canine kidney strain II (MDCKII) cells-MRP2
Glutathione	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Glutathione inhibits the transportation of Dinitrophenyl-glutathione by ABCC2			[32]
Affected Drug/Substrate	Dinitrophenyl-glutathione	Modulation Type	Inhibition
Cell System	Madin-Darby Canine Kidney (MDCK) cells-MRP2
Cefaclor	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cefaclor inhibits the transportation of Estradiol-17beta-glucuronide by ABCC2			[33]
Affected Drug/Substrate	Estradiol-17beta-glucuronide	Modulation Type	Inhibition
Cell System	Spodoptera frugiperda 21-MRP2
Cefadroxil	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cefadroxil inhibits the transportation of Estradiol-17beta-glucuronide by ABCC2			[33]
Affected Drug/Substrate	Estradiol-17beta-glucuronide	Modulation Type	Inhibition
Cell System	Spodoptera frugiperda 21-MRP2
Cefamandole	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cefamandole inhibits the transportation of Estradiol-17beta-glucuronide by ABCC2			[33]
Affected Drug/Substrate	Estradiol-17beta-glucuronide	Modulation Type	Inhibition
Cell System	Spodoptera frugiperda 21-MRP2
Cefmetazole	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cefmetazole inhibits the transportation of Estradiol-17beta-glucuronide by ABCC2			[33]
Affected Drug/Substrate	Estradiol-17beta-glucuronide	Modulation Type	Inhibition
Cell System	Spodoptera frugiperda 21-MRP2
Cefoperazone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cefoperazone inhibits the transportation of Estradiol-17beta-glucuronide by ABCC2			[33]
Affected Drug/Substrate	Estradiol-17beta-glucuronide	Modulation Type	Inhibition
Cell System	Spodoptera frugiperda 21-MRP2
Cefoxitin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cefoxitin inhibits the transportation of Estradiol-17beta-glucuronide by ABCC2			[33]
Affected Drug/Substrate	Estradiol-17beta-glucuronide	Modulation Type	Inhibition
Cell System	Spodoptera frugiperda 21-MRP2
Ceftriaxone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ceftriaxone inhibits the transportation of Estradiol-17beta-glucuronide by ABCC2			[33]
Affected Drug/Substrate	Estradiol-17beta-glucuronide	Modulation Type	Inhibition
Cell System	Spodoptera frugiperda 21-MRP2
Cefuroxime	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cefuroxime inhibits the transportation of Estradiol-17beta-glucuronide by ABCC2			[33]
Affected Drug/Substrate	Estradiol-17beta-glucuronide	Modulation Type	Inhibition
Cell System	Spodoptera frugiperda 21-MRP2
Cephalexin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cephalexin inhibits the transportation of Estradiol-17beta-glucuronide by ABCC2			[33]
Affected Drug/Substrate	Estradiol-17beta-glucuronide	Modulation Type	Inhibition
Cell System	Spodoptera frugiperda 21-MRP2
Cephradine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cephradine inhibits the transportation of Estradiol-17beta-glucuronide by ABCC2			[33]
Affected Drug/Substrate	Estradiol-17beta-glucuronide	Modulation Type	Inhibition
Cell System	Spodoptera frugiperda 21-MRP2
Acitretin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Acitretin inhibits the transportation of Estradiol 17b-D-glucuronide by ABCC2			[19]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Drospirenone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Drospirenone inhibits the transportation of Estradiol 17b-D-glucuronide by ABCC2			[19]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Losartan	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Losartan inhibits the transportation of Estradiol 17b-D-glucuronide by ABCC2			[19]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Sulfasalazine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sulfasalazine inhibits the transportation of Estradiol 17b-D-glucuronide by ABCC2			[19]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Troglitazone	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Troglitazone inhibits the transportation of Estradiol 17b-D-glucuronide by ABCC2			[19]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Quercetin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Quercetin induces the activity of ABCC2			[35]
Cell System	Human enterocyte-like 2 cell (Caco-2)-MRP2
Rifampicin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Rifampicin induces the activity of ABCC2			[36], [37], [38], [39]
Cell System	Human hepatocellular carcinoma cell line (HepG2)-MRP2
Chenodeoxycholic acid	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Chenodiol induces the activity of ABCC2			[40]
Cell System	Human hepatocellular carcinoma cell line (HepG2)-MRP2
DT Modulation2	Chenodeoxycholic acid induces the activity of ABCC2			[40], [81], [82]
Clotrimazole	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Clotrimazole induces the activity of ABCC2			[37]
Cell System	Human hepatocellular carcinoma cell line (HepG2)-MRP2
Phenobarbital	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Phenobarbital induces the activity of ABCC2			[41]
Cell System	Hepatocyte-MRP2
Belinostat	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Belinostat inhibits the activity of ABCC2			[42]
Cell System	Non-small cell lung cancer (NSCLC) cell lines
Rifampin	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Rifampin increases the expression of ABCC2			[48]
Regulation Mechanism	via enhancement of Nuclear receptor subfamily 1 group I member 2 (NR1I2)			Transcription Factor Info
Cell System	Human duodenal mucosa biopsy specimens
Cholic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cholic Acid increases the expression of ABCC2			[49]
Regulation Mechanism	via enhancement of Nuclear receptor subfamily 1 group I member 2 (NR1I2)			Transcription Factor Info
Cell System	C57BL/6 mice
Hydrogen Peroxide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Hydrogen Peroxide increases the expression of ABCC2			[50]
Regulation Mechanism	via enhancement of Nuclear factor erythroid 2-related factor 2 (NFE2L2)			Transcription Factor Info
Cell System	Human neuroblastoma cells (SH-SY5Y)
Fulvestrant	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Fulvestrant increases the expression of ABCC2			[51]
Regulation Mechanism	via modulation of Estrogen receptor (ESR1)			Transcription Factor Info
Cell System	Human breast carcinoma cells (MCF-7)
Ursodeoxycholic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ursodeoxycholic Acid increases the expression of ABCC2			[52]
Regulation Mechanism	via enhancement of Nuclear factor erythroid 2-related factor 2 (NFE2L2)			Transcription Factor Info
Cell System	C57/B6 mice
Arsenic	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Arsenic increases the expression of ABCC2			[55]
Regulation Mechanism	via enhancement of Nuclear factor erythroid 2-related factor 2 (NFE2L2)			Transcription Factor Info
Cell System	Zebrafish
Decitabine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Decitabine increases the expression of ABCC2			[56]
Citalopram	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Citalopram increases the expression of ABCC2			[57]
Atorvastatin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Atorvastatin inhibits the activity of ABCC2			[12]
Lovastatin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Lovastatin inhibits the activity of ABCC2			[12]
Progesterone	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Progesterone inhibits the activity of ABCC2			[58]
Metformin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Metformin increases the expression of ABCC2			[59]
Copper Sulfate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Copper Sulfate increases the expression of ABCC2			[60]
Topotecan	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Topotecan increases the expression of ABCC2			[61]
Paclitaxel	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Paclitaxel affects the expression of ABCC2			[62]
Bortezomib	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Bortezomib increases the expression of ABCC2			[63]
Azathioprine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Azathioprine increases the expression of ABCC2			[64]
Bromfenac	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Bromfenac inhibits the activity of ABCC2			[65]
Celecoxib	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Celecoxib inhibits the activity of ABCC2			[65]
Diclofenac	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Diclofenac inhibits the activity of ABCC2			[65]
Rosiglitazone	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Rosiglitazone inhibits the activity of ABCC2			[65]
Ticlopidine	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ticlopidine inhibits the activity of ABCC2			[65]
Methotrexate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Methotrexate increases the expression of ABCC2			[67]
Epirubicin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Epirubicin increases the expression of ABCC2			[68]
Tolvaptan	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tolvaptan inhibits the activity of ABCC2			[69]
Calcitriol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Calcitriol increases the expression of ABCC2			[70]
Chloroquine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Chloroquine inhibits the expression of ABCC2			[71]
Ethinyl Estradiol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ethinyl Estradiol inhibits the expression of ABCC2			[72]
Macitentan	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Macitentan inhibits the expression of ABCC2			[73]
Urethane	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Urethane inhibits the expression of ABCC2			[74]
Methoxsalen	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Methoxsalen inhibits the expression of ABCC2			[75]
Valproic Acid	5 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Valproic Acid inhibits the expression of ABCC2			[76]
Titanium dioxide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Titanium dioxide increases the expression of ABCC2			[77]
Carbamazepine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Carbamazepine increases the expression of ABCC2			[79]
Acetaminophen	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Acetaminophen inhibits the expression of ABCC2			[80]
Cimetidine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cimetidine inhibits the activity of ABCC2			[8]
Etodolac	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Etodolac inhibits the activity of ABCC2			[13]
Lansoprazole	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Lansoprazole inhibits the activity of ABCC2			[83]
Estradiol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Estradiol induces the activity of ABCC2			[84], [85]
Indinavir	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Indinavir inhibits the activity of ABCC2			[22]
Sulfinpyrazone	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sulfinpyrazone inhibits the activity of ABCC2			[86]
Gentamicin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Gentamicin induces the activity of ABCC2			[87], [88]
Arsenic Trioxide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Arsenic trioxide induces the activity of ABCC2			[89], [90]
Mycophenolic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Mycophenolic acid inhibits the activity of ABCC2			[91]
Pravastatin	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Pravastatin inhibits the activity of ABCC2			[92]
Glyburide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Glibenclamide inhibits the activity of ABCC2			[93]
Verapamil	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Verapamil inhibits the activity of ABCC2			[94]
Mitoxantrone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Mitoxantrone inhibits the activity of ABCC2			[95]
Lopinavir	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Lopinavir inhibits the activity of ABCC2			[96]
Saquinavir	5 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Saquinavir inhibits the activity of ABCC2			[97], [98]
Benzbromarone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Benzbromarone induces the activity of ABCC2			[99]
Montelukast	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Montelukast inhibits the activity of ABCC2			[100]
Estrone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Estrone inhibits the activity of ABCC2			[101]
Ketoconazole	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ketoconazole inhibits the activity of ABCC2			[102]
Levonorgestrel	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Levonorgestrel inhibits the activity of ABCC2			[58]
Midecamycin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Midecamycin inhibits the activity of ABCC2			[103]
Eprosartan	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Eprosartan induces the activity of ABCC2			[104]
Vancomycin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Vancomycin inhibits the activity of ABCC2			[105]
Atazanavir	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Atazanavir inhibits the activity of ABCC2			[106]
Darunavir	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Darunavir inhibits the activity of ABCC2			[106]
Tipranavir	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tipranavir inhibits the activity of ABCC2			[106]
Micafungin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Micafungin inhibits the activity of ABCC2			[107]
Itraconazole	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Itraconazole inhibits the activity of ABCC2			[108]
Troleandomycin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Troleandomycin induces the activity of ABCC2			[109]
Triamcinolone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Triamcinolone induces the activity of ABCC2			[26]
Hydrocortisone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Hydrocortisone induces the activity of ABCC2			[26]
Drug Marketed but not Approved by US FDA
Ginkgolide A	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ginkgolide A increases the expression of ABCC2			[53]
Regulation Mechanism	via enhancement of Nuclear receptor subfamily 1 group I member 2 (NR1I2)			Transcription Factor Info
Cell System	Human hepatoblastoma cells (HepG2)
Bezafibrate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Bezafibrate increases the expression of ABCC2			[54]
Regulation Mechanism	via enhancement of Nuclear receptor subfamily 1 group I member 2 (NR1I2)			Transcription Factor Info
Cell System	Human hepatocellular carcinoma (HepaRG)
Norgestimate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Norgestimate inhibits the activity of ABCC2			[58]
Formononetin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Formononetin inhibits the expression of ABCC2			[66]
Rotenone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Rotenone inhibits the expression of ABCC2			[78]
Drug in Phase 3 Trial
Curcumin	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Curcumin inhibits the transportation of Ethacrynic acid glutathione by ABCC2 (IC50 = 5 microM)			[1]
Affected Drug/Substrate	Ethacrynic acid glutathione	Modulation Type	Inhibition
Cell System	Spodoptera frugiperda (Sf9) cells-MRP2
DT Modulation2	Curcumin inhibits the activity of ABCC2 (IC50 = 5 microM)			[1]
Cell System	Madin Darby canine kidney strain II (MDCKII) cells-MRP2
DT Modulation3	Curcumin inhibits the transportation of Resveratrol-3-O-glucuronide by ABCC2			[11]
Affected Drug/Substrate	Resveratrol-3-O-glucuronide	Modulation Type	Inhibition
Cell System	Madin Darby canine kidney strain II (MDCKII) cells-MRP2
DT Modulation4	Curcumin inhibits the activity of ABCC2			[1]
Cell System	Spodoptera frugiperda (Sf9) cells-MRP2
Resveratrol	6 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Resveratrol increases the expression of ABCC2			[115]
Regulation Mechanism	via enhancement of Nuclear receptor subfamily 1 group I member 2 (NR1I2)			Transcription Factor Info
Cell System	Wistar rats
Triclosan	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Triclosan increases the expression of ABCC2			[139]
Sulforafan	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sulforafan increases the expression of ABCC2			[146]
Benzylpenicillin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Benzylpenicillin induces the activity of ABCC2			[149]
Oltipraz	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Oltipraz increases the expression of ABCC2			[208]
Regulation Mechanism	via enhancement of Nuclear factor erythroid 2-related factor 2 (NFE2L2)			Transcription Factor Info
Affected Drug/Substrate	Arsenic	Modulation Type	Inducer
Cell System	Human hepatocytes
Drug in Phase 2 Trial
Genistein	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Genistein induces the transportation of Sorafenib by ABCC2			[18]
Affected Drug/Substrate	Sorafenib	Modulation Type	Inducer
Cell System	Human hepatocellular carcinoma cell line (HepG2)-MRP2
DT Modulation2	Genistein induces the activity of ABCC2			[18]
Cell System	Human hepatocellular carcinoma cell line (HepG2)-MRP2
Bisphenol A	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Bisphenol A increases the expression of ABCC2			[113]
Regulation Mechanism	via enhancement of Nuclear factor erythroid 2-related factor 2 (NFE2L2)			Transcription Factor Info
Cell System	Human fetal liver samples
Colforsin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Colforsin increases the expression of ABCC2			[124]
Drug in Phase 1 Trial
Trichostatin A	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Trichostatin A inhibits the expression of ABCC2			[116]
Rubitecan	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Rubitecan increases the expression of ABCC2			[118]
HSDB-3466	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	HSDB-3466 inhibits the expression of ABCC2			[75]
Adenosine Triphosphate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Adenosine Triphosphate affects the activity of ABCC2			[142]
Sodium arsenite	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sodium arsenite increases the expression of ABCC2			[78]
TAK-875	7 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	TAK-875 inhibits the activity of ABCC2			[147]
Drug in Preclinical Test
Myricetin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Myricetin inhibits the activity of ABCC2			[119]
Proadifen	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Proadifen inhibits the expression of ABCC2			[135]
(+)-JQ1	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	(+)-JQ1 inhibits the expression of ABCC2			[136]
Discontinued Drug
MK-571	5 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	MK-571 inhibits the transportation of Ethacrynic acid glutathione by ABCC2 (IC50 = 4 microM)			[8]
Affected Drug/Substrate	Ethacrynic acid glutathione	Modulation Type	Inhibition
Cell System	Spodoptera frugiperda (Sf9) cells-MRP2
DT Modulation2	MK-571 inhibits the transportation of Irinotecan by ABCC2 (IC50 = 50 microM)			[9]
Affected Drug/Substrate	Irinotecan	Modulation Type	Inhibition
Cell System	Human enterocyte-like 2 cell (Caco-2)-MRP2
DT Modulation3	MK-571 inhibits the transportation of Leukotriene C4 by ABCC2 (Ki = 13.1 microM)			[2]
Affected Drug/Substrate	Leukotriene C4	Modulation Type	Inhibition
Cell System	LLC-PK1 vesicles-MRP2
DT Modulation4	MK-571 inhibits the transportation of Vinblastine by ABCC2 (Ki = 26.4 microM)			[4]
Affected Drug/Substrate	Vinblastine	Modulation Type	Inhibition
Cell System	Madin Darby canine kidney strain II (MDCKII) cells-MRP2
DT Modulation5	MK-571 inhibits the transportation of Estradiol 17b-D-glucuronide by ABCC2			[10]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Cell System	Madin Darby canine kidney strain II (MDCKII) cells-MRP2
Valspodar	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Valspodar inhibits the transportation of Leukotriene C4 by ABCC2 (Ki = 28.9 microM)			[2]
Affected Drug/Substrate	Leukotriene C4	Modulation Type	Inhibition
Cell System	LLC-PK1 vesicles-MRP2
DT Modulation2	Valspodar inhibits the transportation of Vincristine by ABCC2			[2]
Affected Drug/Substrate	Vincristine	Modulation Type	Inhibition
Cell System	LLC-PK1 vesicles-MRP2
Investigative Drug
Hyperforin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Hyperforin induces the activity of ABCC2			[40]
Cell System	Hepatocyte-MRP2
Lithocholic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Lithocholic Acid inhibits the expression of ABCC2			[110]
Regulation Mechanism	via the inhibition of Bile acid receptor (NR1H4)			Transcription Factor Info
Cell System	Male mice
Beta-naphthoflavone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Beta-naphthoflavone increases the expression of ABCC2			[111]
Regulation Mechanism	via enhancement of Nuclear factor erythroid 2-related factor 2 (NFE2L2)			Transcription Factor Info
Cell System	Human hepatoblastoma cells (HepG2)
Baohuoside I	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Baohuoside I inhibits the expression of ABCC2			[144]
Enoxolone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Enoxolone inhibits the activity of ABCC2			[148]
Patented Pharmaceutical Agent
K-7174	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	K-7174 increases the expression of ABCC2			[126]
BMS 536924	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	BMS 536924 inhibits the expression of ABCC2			[133]
GSK-J4	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	GSK-J4 increases the expression of ABCC2			[138]
Drug Withdrawn
Sitaxsentan	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sitaxsentan inhibits the transportation of Estradiol 17b-D-glucuronide by ABCC2			[19]
Affected Drug/Substrate	Estradiol 17b-D-glucuronide	Modulation Type	Inhibition
Natural Product
Pyrethroids	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Pyrethroids inhibits the transportation of Probenecid by ABCC2 (IC50 = 48.2 microM)			[28]
Affected Drug/Substrate	Probenecid	Modulation Type	Inhibition
Cell System	Human hepatoma HuH-7 cells-MRP2
Tetramethrin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tetramethrin inhibits the transportation of Probenecid by ABCC2 (IC50 = 65.5 microM)			[28]
Affected Drug/Substrate	Probenecid	Modulation Type	Inhibition
Cell System	Human hepatoma HuH-7 cells-MRP2
Cigarette smoke condensate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cigarette smoke condensate inhibits the transportation of Rhodamine 123 by ABCC2 (IC50 = 197.4 microM)			[29]
Affected Drug/Substrate	Rhodamine 123	Modulation Type	Inhibition
Cell System	Human hepatoma HepaRG cells-MRP2
Aged garlic extract	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Aged garlic extract induces the transportation of 2,4-Dinitrophenyl-S-glutathione by ABCC2			[34]
Affected Drug/Substrate	2,4-Dinitrophenyl-S-glutathione	Modulation Type	Inducer
Cell System	Human enterocyte-like 2 cell (Caco-2)-MRP2
DT Modulation1	Quercetin inhibits the reaction ABCC2 protein affects the export of ochratoxin A			[157]
Regulation Mechanism				Transcription Factor Info
Boldine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Boldine induces the activity of ABCC2			[43]
Cell System	Model organism in vivo (rat)
Green tea extract (1mg/ml)	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Green tea extract (1mg/ml) inhibits the activity of ABCC2			[44]
Cell System	Human gastrointestinal epithelial cell line (LS-180)-MRP2
Mix silybin A silybin B	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Mix silybin A silybin B inhibits the activity of ABCC2			[45]
Cell System	Spodoptera frugiperda 21-MRP2
St Johns wort extract	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	St Johns wort extract induces the activity of ABCC2			[46]
Cell System	Model organism in vivo (rat)
Chinese herb Jianpijiedu	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Chinese herb Jianpijiedu induces the activity of ABCC2			[47]
Cell System	Rat breast carcinoma cell (Walker-256)-MRP2
Ginkgolide B	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ginkgolide B increases the expression of ABCC2			[53]
Regulation Mechanism	via enhancement of Nuclear receptor subfamily 1 group I member 2 (NR1I2)			Transcription Factor Info
Cell System	Human hepatoblastoma cells (HepG2)
DT Modulation1	ABCC2 protein affects the export of Resveratrol			[158]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Resveratrol inhibits the reaction ABCC2 protein affects the export of ochratoxin A			[157]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Resveratrol inhibits the reaction Genistein promotes the reaction RXRA protein binds to ABCC2 promoter			[159]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Resveratrol inhibits the reaction Genistein results in increased expression of ABCC2 mRNA			[159]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Resveratrol inhibits the reaction Genistein results in increased expression of ABCC2 protein			[159]
Regulation Mechanism				Transcription Factor Info
Robinetin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Robinetin inhibits the activity of ABCC2			[119]
6-bromoindirubin-3'-oxime	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	6-bromoindirubin-3'-oxime increases the expression of ABCC2			[122]
Chrysin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Chrysin inhibits the activity of ABCC2			[61]
Particulate Matter	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Particulate Matter inhibits the activity of ABCC2			[129]
Senecionine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Senecionine inhibits the expression of ABCC2			[131]
Tobacco Smoke Pollution	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tobacco Smoke Pollution increases the expression of ABCC2			[143]
Plant Extract
Ginkgo biloba extract	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ginkgo biloba extract increases the expression of ABCC2			[53]
Regulation Mechanism	via enhancement of Nuclear receptor subfamily 1 group I member 2 (NR1I2)			Transcription Factor Info
Cell System	Human hepatoblastoma cells (HepG2)
Plant Extracts	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Plant Extracts inhibits the activity of ABCC2			[44]
Apple polyphenol extract	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Apple polyphenol extract increases the expression of ABCC2			[121]
Environmental toxicant
2-tert-butylhydroquinone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	2-tert-butylhydroquinone increases the expression of ABCC2			[112]
Regulation Mechanism	via enhancement of Nuclear factor erythroid 2-related factor 2 (NFE2L2)			Transcription Factor Info
Cell System	Human hepatoblastoma cells (HepG2)
Sodium arsenate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sodium arsenate increases the expression of ABCC2			[117]
Demethoxycurcumin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Demethoxycurcumin inhibits the activity of ABCC2			[120]
Mycotoxins
Aflatoxin B1	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Aflatoxin B1 increases the expression of ABCC2			[125]
Zearalenone	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCC2 protein results in increased transport of Zearalenone			[197]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	verlukast inhibits the reaction ABCC2 protein results in increased transport of Zearalenone			[197]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Zearalenone inhibits the reaction ABCC2 protein results in increased transport of calcein AM			[197]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Zearalenone results in increased expression of ABCC2 mRNA			[124]
Regulation Mechanism				Transcription Factor Info
Acute Toxic Substance
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine increases the expression of ABCC2			[123]
Ochratoxin A	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ochratoxin A inhibits the expression of ABCC2			[134]
2-methyl-4-isothiazolin-3-one	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	2-methyl-4-isothiazolin-3-one increases the expression of ABCC2			[140]
Carcinogen
2-acetylaminofluorene	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	2-acetylaminofluorene increases the expression of ABCC2			[111]
Regulation Mechanism	via enhancement of Nuclear factor erythroid 2-related factor 2 (NFE2L2)			Transcription Factor Info
Cell System	Human hepatoblastoma cells (HepG2)
Benzo(a)pyrene	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Benzo(a)pyrene inhibits the expression of ABCC2			[141]
Pesticide/Insecticide
Chlordecone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Chlordecone inhibits the activity of ABCC2			[128]
Dieldrin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Dieldrin increases the expression of ABCC2			[128]
Endosulfan	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Endosulfan inhibits the activity of ABCC2			[128]
Heptachlor	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Heptachlor inhibits the activity of ABCC2			[128]
Dicrotophos	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Dicrotophos increases the expression of ABCC2			[137]
Health and Environmental Toxicant
Perfluorooctane sulfonic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Perfluorooctane sulfonic acid increases the expression of ABCC2			[114]
Regulation Mechanism	via enhancement of Peroxisome proliferator-activated receptor alpha (PPARA)			Transcription Factor Info
Cell System	Sprague Dawley rats
Chlordan	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Chlordan inhibits the activity of ABCC2			[128]
Butyraldehyde	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Butyraldehyde inhibits the expression of ABCC2			[130]
tris(1,3-dichloro-2-propyl)phosphate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	tris(1,3-dichloro-2-propyl)phosphate increases the expression of ABCC2			[132]
Herbicide
Monomethylarsonic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Monomethylarsonic acid increases the expression of ABCC2			[127]
2,4,5-trichlorophenoxyacetic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	2,4,5-trichlorophenoxyacetic Acid increases the expression of ABCC2			[111]
Chemical Compound
DT Modulation1	ABCC2 protein affects the transport of Vinblastine			[154]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	isopropyl 5,12-hydroxypentadeca-8,10-dien-6,14-diynoate results in decreased activity of ABCC2 protein which results in increased uptake of Vinblastine			[203]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Probenecid promotes the reaction ABCC2 protein affects the transport of Vinblastine			[154]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	verlukast results in decreased activity of ABCC2 protein which results in increased uptake of Vinblastine			[203]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Probenecid inhibits the reaction ABCC2 protein affects the export of 6-carboxyfluorescein			[153]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Probenecid inhibits the reaction ABCC2 protein results in increased export of 5(6)-carboxy-2',7'-dichlorofluorescein analog			[29]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Probenecid promotes the reaction ABCC2 protein affects the transport of Docetaxel			[154]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Probenecid promotes the reaction ABCC2 protein affects the transport of estradiol-17 beta-glucuronide			[155]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Probenecid promotes the reaction ABCC2 protein affects the transport of Etoposide			[154]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Probenecid promotes the reaction ABCC2 protein affects the transport of Paclitaxel			[154]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	Probenecid promotes the reaction ABCC2 protein affects the transport of Vinblastine			[154]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	Probenecid promotes the reaction ABCC2 protein results in decreased susceptibility to Paclitaxel			[154]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	Probenecid results in increased activity of ABCC2 protein			[154]
Regulation Mechanism				Transcription Factor Info
DT Modulation10	yu ping feng san inhibits the reaction Probenecid results in increased activity of ABCC2 protein			[156]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	ABCC2 polymorphism affects the susceptibility to Simvastatin			[165]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	ABCC2 protein binds to and results in increased uptake of Simvastatin analog			[151]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Simvastatin analog inhibits the reaction ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein			[151]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Simvastatin analog inhibits the reaction ABCC2 protein results in increased transport of calcein AM			[12]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Simvastatin analog results in decreased activity of ABCC2 protein			[12]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	ABCC2 protein affects the export of and results in decreased susceptibility to Vincristine			[204]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	ABCC2 protein affects the export of Vincristine			[204]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	ABCC2 protein results in decreased susceptibility to Vincristine			[204]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	myricetin inhibits the reaction ABCC2 protein affects the export of and results in decreased susceptibility to Vincristine			[204]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	myricetin inhibits the reaction ABCC2 protein affects the export of Vincristine			[204]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	myricetin inhibits the reaction ABCC2 protein results in decreased susceptibility to Vincristine			[204]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	Vincristine results in decreased susceptibility to Vincristine which results in increased expression of ABCC2 mRNA			[205]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	SLCO1B1 protein co-treated with ABCC2 protein results in increased transport of Troglitazone analog			[192]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Troglitazone results in decreased activity of ABCC2 protein			[65]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Troglitazone results in increased expression of ABCC2 mRNA			[59]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	ABCC2 protein affects the export of Rifampin			[39]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Rifampin co-treated with ABCC2 gene mutant form results in increased expression of ABCC3 protein			[160]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Progesterone results in decreased activity of ABCC2 protein			[58]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	chrysin results in decreased activity of ABCC2 protein which results in decreased export of Topotecan			[61]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	verlukast results in decreased activity of ABCC2 protein which results in decreased export of Topotecan			[61]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Rosiglitazone results in decreased activity of ABCC2 protein			[65]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Rosiglitazone results in increased expression of ABCC2 mRNA			[161]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Ticlopidine results in decreased activity of ABCC2 protein			[65]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Tolvaptan metabolite results in decreased activity of ABCC2 protein			[69]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Valproic Acid results in decreased activity of ABCC2 protein			[152]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Valproic Acid results in increased expression of ABCC2 mRNA			[195]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Valproic Acid results in increased expression of ABCC2 protein			[76]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Valproic Acid results in increased methylation of ABCC2 gene			[76]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Sulfinpyrazone results in decreased activity of ABCC2 protein			[176]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	ABCC2 protein affects the export of Pravastatin			[150]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	ABCC2 protein binds to and results in increased uptake of Pravastatin analog			[151]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Pravastatin analog inhibits the reaction ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein			[151]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Verapamil inhibits the reaction ABCC2 protein affects the export of 5-carboxyfluorescein diacetate			[196]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	ABCC2 protein affects the export of Saquinavir			[163]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	ABCC2 protein results in increased export of Saquinavir			[164]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	montelukast inhibits the reaction ABCC2 protein results in increased export of Saquinavir			[100]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	verlukast inhibits the reaction ABCC2 protein results in increased export of Saquinavir			[100]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Proadifen co-treated with Cisplatin results in increased expression of ABCC2 protein			[135]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Triclosan results in decreased expression of ABCC2 mRNA			[189]
Regulation Mechanism				Transcription Factor Info
Gold	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Gold increases the expression of ABCC2			[145]
DT Modulation1	TAK-875 affects the activity of ABCC2 protein			[179]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	TAK-875 affects the reaction ABCC2 protein results in increased transport of Bile Acids and Salts			[179]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	TAK-875 analog results in decreased activity of ABCC2 protein			[179]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	TAK-875 inhibits the reaction ABCC2 protein results in increased transport of Bile Acids and Salts			[179]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	TAK-875 metabolite results in decreased activity of ABCC2 protein			[180]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	TAK-875 results in decreased activity of ABCC2 protein			[147]
Regulation Mechanism				Transcription Factor Info
Primidone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Primidone results in decreased activity of ABCC2 protein			[152]
Regulation Mechanism				Transcription Factor Info
robinetin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	robinetin inhibits the reaction ABCC2 protein affects the export of fluorexon			[119]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	robinetin results in decreased activity of ABCC2 protein			[119]
Regulation Mechanism				Transcription Factor Info
Rosuvastatin Calcium	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCC2 protein binds to and results in increased uptake of Rosuvastatin Calcium analog			[151]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Rosuvastatin Calcium analog inhibits the reaction ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein			[151]
Regulation Mechanism				Transcription Factor Info
rubitecan	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	rubitecan results in increased expression of ABCC2 mRNA			[118]
Regulation Mechanism				Transcription Factor Info
S-(2,4-dinitrophenyl)glutathione	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCC2 protein affects the transport of S-(2,4-dinitrophenyl)glutathione			[162]
Regulation Mechanism				Transcription Factor Info
senecionine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	senecionine results in decreased expression of ABCC2 mRNA			[131]
Regulation Mechanism				Transcription Factor Info
Sincalide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCC2 protein affects the export of Sincalide			[166]
Regulation Mechanism				Transcription Factor Info
sodium arsenate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	sodium arsenate results in increased expression of ABCC2 mRNA			[117]
Regulation Mechanism				Transcription Factor Info
sodium arsenite	6 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCC2 results in decreased susceptibility to sodium arsenite			[167]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	sodium arsenite affects the expression of ABCC2 protein			[168]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	sodium arsenite results in increased abundance of arsenite which results in increased expression of ABCC2 mRNA			[169]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	sodium arsenite results in increased expression of ABCC2 mRNA			[170]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	sodium arsenite results in increased expression of ABCC2 protein			[170]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	SPDL1 protein promotes the reaction sodium arsenite results in increased expression of ABCC2 protein			[168]
Regulation Mechanism				Transcription Factor Info
Sodium Dodecyl Sulfate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sodium Dodecyl Sulfate results in increased expression of ABCC2 mRNA			[171]
Regulation Mechanism				Transcription Factor Info
sodium selenide	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCC2 protein affects the reaction sodium selenide results in increased transport of arsenite			[172]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	sodium selenide inhibits the reaction arsenite results in increased expression of ABCC2 protein			[172]
Regulation Mechanism				Transcription Factor Info
Sodium Selenite	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sodium Selenite inhibits the reaction arsenite results in increased expression of ABCC2 protein			[172]
Regulation Mechanism				Transcription Factor Info
Sorafenib	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCC2 affects the susceptibility to Sorafenib			[173]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	SNHG1 protein affects the susceptibility to Sorafenib which affects the expression of ABCC2 protein			[174]
Regulation Mechanism				Transcription Factor Info
Succimer	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCC2 results in increased transport of Succimer metabolite			[175]
Regulation Mechanism				Transcription Factor Info
sulfanitran	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	sulfanitran promotes the reaction ABCC2 protein affects the transport of estradiol-17 beta-glucuronide			[98]
Regulation Mechanism				Transcription Factor Info
Sulfobromophthalein	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCC2 protein affects the export of Sulfobromophthalein			[177]
Regulation Mechanism				Transcription Factor Info
sulforaphane	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	sulforaphane results in increased expression of ABCC2 mRNA			[178]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	sulforaphane results in increased expression of ABCC2 protein			[178]
Regulation Mechanism				Transcription Factor Info
Tamoxifen	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCC2 gene affects the susceptibility to Tamoxifen			[181]
Regulation Mechanism				Transcription Factor Info
tanshinone	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	tanshinone co-treated with Acetaminophen results in increased expression of ABCC2 mRNA			[182]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	tanshinone co-treated with Acetaminophen results in increased expression of ABCC2 protein			[182]
Regulation Mechanism				Transcription Factor Info
Tartrazine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Tartrazine results in decreased expression of ABCC2 mRNA			[183]
Regulation Mechanism				Transcription Factor Info
Temozolomide	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCC2 mRNA affects the susceptibility to Temozolomide			[184]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate results in decreased susceptibility to Temozolomide which results in increased expression of ABCC2 mRNA			[185]
Regulation Mechanism				Transcription Factor Info
tert-Butylhydroperoxide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	tert-Butylhydroperoxide results in decreased expression of ABCC2 mRNA			[186]
Regulation Mechanism				Transcription Factor Info
theaflavin-3,3'-digallate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	theaflavin-3,3'-digallate affects the expression of ABCC2 mRNA			[187]
Regulation Mechanism				Transcription Factor Info
Theophylline	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Theophylline results in decreased activity of ABCC2 protein			[152]
Regulation Mechanism				Transcription Factor Info
Thiabendazole	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Thiabendazole results in increased expression of ABCC2 mRNA			[188]
Regulation Mechanism				Transcription Factor Info
titanium dioxide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	titanium dioxide results in increased expression of ABCC2 mRNA			[77]
Regulation Mechanism				Transcription Factor Info
trichostatin A	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	trichostatin A results in decreased expression of ABCC2 mRNA			[116]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	trichostatin A results in decreased expression of ABCC2 protein			[116]
Regulation Mechanism				Transcription Factor Info
triphenyl phosphate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	triphenyl phosphate affects the expression of ABCC2 mRNA			[190]
Regulation Mechanism				Transcription Factor Info
triptolide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	triptolide results in decreased expression of ABCC2 protein			[191]
Regulation Mechanism				Transcription Factor Info
Unithiol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCC2 results in increased transport of Unithiol metabolite			[175]
Regulation Mechanism				Transcription Factor Info
vadimezan	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCC2 protein affects the export of vadimezan metabolite			[193]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	ABCC2 protein affects the transport of vadimezan analog			[194]
Regulation Mechanism				Transcription Factor Info
verlukast	17 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	verlukast inhibits the reaction ABCC2 protein results in increased export of calcein AM			[100]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	verlukast inhibits the reaction ABCC2 protein results in increased export of Paclitaxel			[100]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	verlukast inhibits the reaction ABCC2 protein results in increased export of Saquinavir			[100]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	verlukast inhibits the reaction ABCC2 protein results in increased transport of calcein AM			[197]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	verlukast inhibits the reaction ABCC2 protein results in increased transport of Leukotriene C4			[198]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	verlukast inhibits the reaction ABCC2 protein results in increased transport of zearalenol			[197]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	verlukast inhibits the reaction ABCC2 protein results in increased transport of Zearalenone			[197]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	verlukast inhibits the reaction Adenosine Triphosphate co-treated with ABCC2 protein results in increased uptake of estradiol-17 beta-glucuronide			[199]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	verlukast inhibits the reaction Bucladesine results in increased activity of ABCC2 protein			[200]
Regulation Mechanism				Transcription Factor Info
DT Modulation10	verlukast results in decreased activity of ABCC2 protein			[201]
Regulation Mechanism				Transcription Factor Info
DT Modulation11	verlukast results in decreased activity of ABCC2 protein which results in decreased export of Topotecan			[61]
Regulation Mechanism				Transcription Factor Info
DT Modulation12	verlukast results in decreased activity of ABCC2 protein which results in decreased transport of benzoylaconine			[202]
Regulation Mechanism				Transcription Factor Info
DT Modulation13	verlukast results in decreased activity of ABCC2 protein which results in decreased transport of benzoylhypaconine			[202]
Regulation Mechanism				Transcription Factor Info
DT Modulation14	verlukast results in decreased activity of ABCC2 protein which results in decreased transport of benzoylmesaconine			[202]
Regulation Mechanism				Transcription Factor Info
DT Modulation15	verlukast results in decreased activity of ABCC2 protein which results in decreased transport of hypaconitine			[202]
Regulation Mechanism				Transcription Factor Info
DT Modulation16	verlukast results in decreased activity of ABCC2 protein which results in decreased transport of mesaconitine			[202]
Regulation Mechanism				Transcription Factor Info
DT Modulation17	verlukast results in decreased activity of ABCC2 protein which results in increased uptake of Vinblastine			[203]
Regulation Mechanism				Transcription Factor Info
Y 27632	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Y 27632 results in increased expression of ABCC2 mRNA			[206]
Regulation Mechanism				Transcription Factor Info
zafirlukast	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	zafirlukast results in decreased activity of ABCC2 protein			[152]
Regulation Mechanism				Transcription Factor Info
zearalenol	7 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ABCC2 protein results in increased transport of zearalenol			[197]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	verlukast inhibits the reaction ABCC2 protein results in increased transport of zearalenol			[197]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	zearalenol inhibits the reaction ABCC2 protein results in increased transport of calcein AM			[197]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	zearalenol results in decreased expression of ABCC2 mRNA			[207]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	zearalenol results in decreased expression of ABCC2 protein			[207]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	zearalenol results in increased expression of ABCC2 mRNA			[207]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	zearalenol results in increased expression of ABCC2 protein			[207]
Regulation Mechanism				Transcription Factor Info

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77	Genome-wide DNA methylome and transcriptome changes induced by inorganic nanoparticles in human kidney cells after chronic exposure. Cell Biol Toxicol. 2022 Jan 1.
78	Capturing time-dependent activation of genes and stress-response pathways using transcriptomics in iPSC-derived renal proximal tubule cells. Cell Biol Toxicol. 2022 Dec 31.
79	Transcriptional profiling of genes induced in the livers of patients treated with carbamazepine. Clin Pharmacol Ther. 2006 Nov;80(5):440-456.
80	Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans. Arch Toxicol. 2018 Feb;92(2):845-858.
81	Clinical trial: modulation of human placental multidrug resistance proteins in cholestasis of pregnancy by ursodeoxycholic acid. Aliment Pharmacol Ther. 2007 Oct 15;26(8):1139-46.
82	Role of nuclear bile acid receptor, FXR, in adaptive ABC transporter regulation by cholic and ursodeoxycholic acid in mouse liver, kidney and intestine. J Hepatol. 2003 Oct;39(4):480-8.
83	KEGG: new perspectives on genomes, pathways, diseases and drugs. Nucleic Acids Res. 2017 Jan 4;45(D1):D353-D361. (dg:DG02867)
84	Inhibition of transport across the hepatocyte canalicular membrane by the antibiotic fusidate. Biochem Pharmacol. 2002 Jul 1;64(1):151-8.
85	Involvement of Mrp2/MRP2 in the species different excretion route of benzylpenicillin between rat and human. Xenobiotica. 2009 Feb;39(2):171-81.
86	Vinblastine and sulfinpyrazone export by the multidrug resistance protein MRP2 is associated with glutathione export. Br J Cancer. 2000 Aug;83(3):375-83.
87	Increased apical insertion of the multidrug resistance protein 2 (MRP2/ABCC2) in renal proximal tubules following gentamicin exposure. J Pharmacol Exp Ther. 2006 Sep;318(3):1194-202.
88	Short-term exposure of renal proximal tubules to gentamicin increases long-term multidrug resistance protein 2 (Abcc2) transport function and reduces nephrotoxicant sensitivity. J Pharmacol Exp Ther. 2005 Nov;315(2):912-20.
89	MRP2 and acquired tolerance to inorganic arsenic in the kidney of killifish (Fundulus heteroclitus). Toxicol Sci. 2007 May;97(1):103-10.
90	Effects of MRP2-GSH cotransport system on hepatic arsenic metabolism in rats. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2006 May;24(5):278-80.
91	C-440T/T-331C polymorphisms in the UGT1A9 gene affect the pharmacokinetics of mycophenolic acid in kidney transplantation. Pharmacogenomics. 2007 Sep;8(9):1127-41.
92	Role of transporters in the tissue-selective distribution and elimination of drugs: transporters in the liver, small intestine, brain and kidney. J Control Release. 2002 Jan 17;78(1-3):43-54.
93	Estimation of transporters involved in the hepatobiliary transport of TA-0201CA using sandwich-cultured rat hepatocytes from normal and multidrug resistance-associated protein 2-deficient rats. Drug Metab Dispos. 2010 Sep;38(9):1505-13.
94	Molecular mechanisms of biliary excretion of cefditoren and the effects of cefditoren on the expression levels of hepatic transporters. Drug Metab Pharmacokinet. 2010;25(4):320-7.
95	Presence or absence of a gallate moiety on catechins affects their cellular transport. J Pharm Pharmacol. 2008 Sep;60(9):1189-95.
96	Peptide prodrugs: improved oral absorption of lopinavir, a HIV protease inhibitor. Int J Pharm. 2008 Jul 9;359(1-2):7-14.
97	Multidrug resistance protein 2 (MRP2) transports HIV protease inhibitors, and transport can be enhanced by other drugs. AIDS. 2002 Nov 22;16(17):2295-301.
98	Evidence for two interacting ligand binding sites in human multidrug resistance protein 2 (ATP binding cassette C2). J Biol Chem. 2003 Jun 27;278(26):23538-44.
99	Transport of diclofenac by breast cancer resistance protein (ABCG2) and stimulation of multidrug resistance protein 2 (ABCC2)-mediated drug transport by diclofenac and benzbromarone. Drug Metab Dispos. 2009 Jan;37(1):129-36.
100	Montelukast is a potent and durable inhibitor of multidrug resistance protein 2-mediated efflux of taxol and saquinavir. Biol Pharm Bull. 2009 Dec;32(12):2002-9.
101	Modulation of human multidrug resistance protein (MRP) 1 (ABCC1) and MRP2 (ABCC2) transport activities by endogenous and exogenous glutathione-conjugated catechol metabolites. Drug Metab Dispos. 2008 Mar;36(3):552-60.
102	CYP1A1 induction and CYP3A4 inhibition by the fungicide imazalil in the human intestinal Caco-2 cells-comparison with other conazole pesticides. Toxicol Lett. 2009 Feb 10;184(3):159-68.
103	Potential cholestatic activity of various therapeutic agents assessed by bile canalicular membrane vesicles isolated from rats and humans. Drug Metab Pharmacokinet. 2003;18(1):16-22.
104	Interaction of angiotensin receptor type 1 blockers with ATP-binding cassette transporters. Biopharm Drug Dispos. 2010 Mar;31(2-3):150-61.
105	JBP485 attenuates vancomycin-induced nephrotoxicity by regulating the expressions of organic anion transporter (Oat) 1, Oat3, organic cation transporter 2 (Oct2), multidrug resistance-associated protein 2 (Mrp2) and P-glycoprotein (P-gp) in rats. Toxicol Lett. 2018 Oct 1;295:195-204.
106	MRP2 Inhibition by HIV Protease Inhibitors in Rat and Human Hepatocytes: A Quantitative Confocal Microscopy Study. Drug Metab Dispos. 2018 May;46(5):697-703.
107	Inhibitory Potential of Antifungal Drugs on ATP-Binding Cassette Transporters P-Glycoprotein, MRP1 to MRP5, BCRP, and BSEP. Antimicrob Agents Chemother. 2016 May 23;60(6):3372-9.
108	Evaluation of Ketoconazole and Its Alternative Clinical CYP3A4/5 Inhibitors as Inhibitors of Drug Transporters: The In Vitro Effects of Ketoconazole, Ritonavir, Clarithromycin, and Itraconazole on 13 Clinically-Relevant Drug Transporters. Drug Metab Dispos. 2016 Mar;44(3):453-9.
109	Interactions of pharmaceuticals and other xenobiotics on key detoxification mechanisms and cytoskeleton in Poeciliopsis lucida hepatocellular carcinoma, PLHC-1 cell line. Toxicol In Vitro. 2013 Feb;27(1):111-20.
110	Preventive effect of Juniperus procera extract on liver injury induced by lithocholic acid. Cell Mol Biol (Noisy-le-grand). 2018 Oct 30;64(13):63-68.
111	Role of Nrf2 in the regulation of the Mrp2 (ABCC2) gene. Biochem J. 2006 May 1;395(3):599-609.
112	Nrf2-dependent and -independent induction of ABC transporters ABCC1, ABCC2, and ABCG2 in HepG2 cells under oxidative stress. J Exp Ther Oncol. 2007;6(4):335-48.
113	Correlation between Conjugated Bisphenol A Concentrations and Efflux Transporter Expression in Human Fetal Livers. Drug Metab Dispos. 2016 Jul;44(7):1061-5.
114	PPAR-alpha, a lipid-sensing transcription factor, regulates blood-brain barrier efflux transporter expression. J Cereb Blood Flow Metab. 2017 Apr;37(4):1199-1212.
115	Resveratrol modifies biliary secretion of cholephilic compounds in sham-operated and cholestatic rats. World J Gastroenterol. 2017 Nov 21;23(43):7678-7692.
116	Characterization of the 5'-flanking region of the human multidrug resistance protein 2 (MRP2) gene and its regulation in comparison withthe multidrug resistance protein 3 (MRP3) gene. Eur J Biochem. 2000 Mar;267(5):1347-58.
117	Global alteration of gene expression in human keratinocytes by inorganic arsenic. Carcinogenesis. 2003 Apr;24(4):747-56.
118	Analysis of ATP-binding cassette transporter expression in drug-selected cell lines by a microarray dedicated to multidrug resistance. Mol Pharmacol. 2004 Dec;66(6):1397-405.
119	Quantitative structure activity relationship studies on the flavonoid mediated inhibition of multidrug resistance proteins 1 and 2. Biochem Pharmacol. 2005 Feb 15;69(4):699-708.
120	Inhibition of multidrug resistance proteins MRP1 and MRP2 by a series of alpha,beta-unsaturated carbonyl compounds. Biochem Pharmacol. 2005 Jun 15;69(12):1879-90.
121	Apple polyphenols modulate expression of selected genes related to toxicological defence and stress response in human colon adenoma cells. Int J Cancer. 2008 Jun 15;122(12):2647-55.
122	Activation of beta-catenin signalling by GSK-3 inhibition increases p-glycoprotein expression in brain endothelial cells. J Neurochem. 2008 Aug;106(4):1855-65.
123	ABCG2/BCRP decreases the transfer of a food-born chemical carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in perfused term human placenta. Toxicol Appl Pharmacol. 2008 Oct 15;232(2):210-7.
124	Induction of cells differentiation and ABC transporters expression by a myco-estrogen, zearalenone, in human choriocarcinoma cell line (BeWo). Toxicology. 2009 Sep 19;263(2-3):100-7.
125	The effects of aflatoxin B1 on transporters and steroid metabolizing enzymes in JEG-3 cells. Toxicol Lett. 2013 Apr 26;218(3):200-6.
126	A low-molecular-weight compound K7174 represses hepcidin: possible therapeutic strategy against anemia of chronic disease. PLoS One. 2013 Sep 27;8(9):e75568.
127	Methylarsonous acid causes oxidative DNA damage in cells independent of the ability to biomethylate inorganic arsenic. Arch Toxicol. 2014 Feb;88(2):249-61.
128	Regulation of hepatic drug transporter activity and expression by organochlorine pesticides. J Biochem Mol Toxicol. 2014 Mar;28(3):119-28.
129	Regulation of human hepatic drug transporter activity and expression by diesel exhaust particle extract. PLoS One. 2015 Mar 24;10(3):e0121232.
130	Integrated analysis of microRNA and mRNA expression profiles highlights aldehyde-induced inflammatory responses in cells relevant for lung toxicity. Toxicology. 2015 Aug 6;334:111-21.
131	Disturbance of gene expression in primary human hepatocytes by hepatotoxic pyrrolizidine alkaloids: A whole genome transcriptome analysis. Toxicol In Vitro. 2015 Oct;29(7):1669-82.
132	Defensive and adverse energy-related molecular responses precede tris (1, 3-dichloro-2-propyl) phosphate cytotoxicity. J Appl Toxicol. 2016 May;36(5):649-58.
133	Enhancement effect of resveratrol on the intestinal absorption of bestatin by regulating PEPT1, MDR1 and MRP2 in vivo and in vitro. Int J Pharm. 2015 Nov 10;495(1):588-598.
134	Modulation of the xenobiotic transformation system and inflammatory response by ochratoxin A exposure using a co-culture system of Caco-2 and HepG2 cells. Food Chem Toxicol. 2015 Dec;86:245-52.
135	Proadifen sensitizes resistant ovarian adenocarcinoma cells to cisplatin. Toxicol Lett. 2016 Jan 22;243:56-66.
136	CCAT1 is an enhancer-templated RNA that predicts BET sensitivity in colorectal cancer. J Clin Invest. 2016 Feb;126(2):639-52.
137	Molecular mechanisms of discrotophos-induced toxicity in HepG2 cells: The role of CSA in oxidative stress. Food Chem Toxicol. 2017 May;103:253-260.
138	Inhibition of histone H3K27 demethylases selectively modulates inflammatory phenotypes of natural killer cells. J Biol Chem. 2018 Feb 16;293(7):2422-2437.
139	Triclosan treatment decreased the antitumor effect of sorafenib on hepatocellular carcinoma cells. Onco Targets Ther. 2018 May 18;11:2945-2954.
140	Methylisothiazolinone induces apoptotic cell death via matrix metalloproteinase activation in human bronchial epithelial cells. Toxicol In Vitro. 2020 Feb;62:104661.
141	Identification of a transcriptomic signature of food-relevant genotoxins in human HepaRG hepatocarcinoma cells. Food Chem Toxicol. 2020 Jun;140:111297.
142	Human multidrug resistance protein 4 (MRP4) is a cellular efflux transporter for paracetamol glutathione and cysteine conjugates. Arch Toxicol. 2020 Sep;94(9):3027-3032.
143	Integration of transcriptome analysis with pathophysiological endpoints to evaluate cigarette smoke toxicity in an in vitro human airway tissue model. Arch Toxicol. 2021 May;95(5):1739-1761.
144	Baohuoside I inhibits FXR signaling pathway to interfere with bile acid homeostasis via targeting ER alpha degradation. Cell Biol Toxicol. 2022 Jul 8.
145	Biocorona modulates the inflammatory response induced by gold nanoparticles in human epidermal keratinocytes. Toxicol Lett. 2022 Oct 1;369:34-42.
146	Molecular mechanisms of hepatotoxic cholestasis by clavulanic acid: Role of NRF2 and FXR pathways. Food Chem Toxicol. 2021 Dec;158:112664.
147	Fasiglifam (TAK-875): Mechanistic Investigation and Retrospective Identification of Hazards for Drug Induced Liver Injury. Toxicol Sci. 2018 Jun 1;163(2):374-384.
148	Inhibitory effects of terpenoids on multidrug resistance-associated protein 2- and breast cancer resistance protein-mediated transport. Drug Metab Dispos. 2008 Jul;36(7):1206-11.
149	Interactions of the human multidrug resistance proteins MRP1 and MRP2 with organic anions. Mol Pharmacol. 2000 Apr;57(4):760-8.
150	Identification of the hepatic efflux transporters of organic anions using double-transfected Madin-Darby canine kidney II cells expressing human organic anion-transporting polypeptide 1B1 (OATP1B1)/multidrug resistance-associated protein 2, OATP1B1/multidrug resistance 1, and OATP1B1/breast cancer resistance protein. J Pharmacol Exp Ther. 2005;314(3):1059-67.
151	ATP-dependent transport of statins by human and rat MRP2/Mrp2. Toxicol Appl Pharmacol. 2013;269(2):187-94.
152	Identification of reversible OATP1B1 and time-dependent CYP3A4 inhibition as the major risk factors for drug-induced cholestasis (DIC). Arch Toxicol. 2024;98(10):3409-3424.
153	Identification and functional analysis of two novel mutations in the multidrug resistance protein 2 gene in Israeli patients with Dubin-Johnson syndrome. J Biol Chem. 2001;276(40):36923-30.
154	MRP2 (ABCC2) transports taxanes and confers paclitaxel resistance and both processes are stimulated by probenecid. Int J Cancer. 2005;116(5):824-9.
155	Differential modulation of the human liver conjugate transporters MRP2 and MRP3 by bile acids and organic anions. J Biol Chem. 2003;278(26):23529-37.
156	The Mechanisms of Yu Ping Feng San in Tracking the Cisplatin-Resistance by Regulating ATP-Binding Cassette Transporter and Glutathione S-Transferase in Lung Cancer Cells. Front Pharmacol. 2021;12:678126.
157	Differential modulation of ochratoxin A absorption across Caco-2 cells by dietary polyphenols, used at realistic intestinal concentrations. Toxicol Lett. 2005;159(1):60-70.
158	Cellular uptake and efflux of trans-piceid and its aglycone trans-resveratrol on the apical membrane of human intestinal Caco-2 cells. J Agric Food Chem. 2005;53(3):798-803.
159	Resveratrol inhibits genistein-induced multi-drug resistance protein 2 (MRP2) expression in HepG2 cells. Arch Biochem Biophys. 2011;512(2):160-6.
160	Identification of a novel 974C-->G nonsense mutation of the MRP2/ABCC2 gene in a patient with Dubin-Johnson syndrome and analysis of the effects of rifampicin and ursodeoxycholic acid on serum bilirubin and bile acids. Am J Gastroenterol. 2006 Oct;101(10):2427-32.
161	Transcriptomic analysis of untreated and drug-treated differentiated HepaRG cells over a 2-week period. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):27-35.
162	Treatment of hyperbilirubinemia in Eisai hyperbilirubinemic rat by transfecting human MRP2/ABCC2 gene. Pharm Res. 2005;22(4):661-6.
163	Human organic anion-transporting polypeptide OATP-A (SLC21A3) acts in concert with P-glycoprotein and multidrug resistance protein 2 in the vectorial transport of Saquinavir in Hep G2 cells. Mol Pharm. 2004 Jan 12;1(1):49-56.
164	MRP (ABCC) transporters-mediated efflux of anti-HIV drugs, saquinavir and zidovudine, from human endothelial cells. Exp Biol Med (Maywood). 2008;233(9):1149-60.
165	Genetic variation in the ABCC2 gene is associated with dose decreases or switches to other cholesterol-lowering drugs during simvastatin and atorvastatin therapy. Pharmacogenomics J. 2013 Jun;13(3):251-6.
166	Vectorial transport of the peptide CCK-8 by double-transfected MDCKII cells stably expressing the organic anion transporter OATP1B3 (OATP8) and the export pump ABCC2. J Pharmacol Exp Ther. 2005;313(2):549-56.
167	Enhanced expression of multidrug resistance-associated protein 2 and reduced expression of aquaglyceroporin 3 in an arsenic-resistant human cell line. J Biol Chem. 2006;281(27):18401-7.
168	Effect of the ARG1 gene on arsenic resistance of 293T cells. Genet Mol Res. 2013;12(4):6825-37.
169	Deducing signaling pathways from parallel actions of arsenite and antimonite in human epidermal keratinocytes. Sci Rep. 2020;10(1):2890.
170	Arsenic induces expression of the multidrug resistance-associated protein 2 (MRP2) gene in primary rat and human hepatocytes. J Pharmacol Exp Ther. 2001;298(1):234-9.
171	CXCL14 downregulation in human keratinocytes is a potential biomarker for a novel in vitro skin sensitization test. Toxicol Appl Pharmacol. 2020;386:114828.
172	Biliary excretion of arsenic by human HepaRG cells is stimulated by selenide and mediated by the multidrug resistance protein 2 (MRP2/ABCC2). Biochem Pharmacol. 2021;193:114799.
173	The Enhanced metastatic potential of hepatocellular carcinoma (HCC) cells with sorafenib resistance. PLoS One. 2013;8(11):e78675.
174	SNHG1, interacting with SND1, contributes to sorafenib resistance of liver cancer cells by increasing m6A-mediated SLC7A11 expression and promoting aerobic glycolysis. Environ Toxicol. 2024;39(3):1269-1282.
175	MRP2 involvement in renal proximal tubular elimination of methylmercury mediated by DMPS or DMSA. Toxicol Appl Pharmacol. 2009 Feb 15;235(1):10-7.
176	Role of multidrug resistance protein 2 (MRP2, ABCC2) in alkylating agent detoxification: MRP2 potentiates glutathione S-transferase A1-1-mediated resistance to chlorambucil cytotoxicity. J Pharmacol Exp Ther. 2004;308(1):260-7.
177	Human hepatobiliary transport of organic anions analyzed by quadruple-transfected cells. Mol Pharmacol. 2005 Oct;68(4):1031-8.
178	Reactive oxygen species-related induction of multidrug resistance-associated protein 2 expression in primary hepatocytes exposed to sulforaphane. Biochem Biophys Res Commun. 2001;282(1):257-63.
179	Fasiglifam (TAK-875) Alters Bile Acid Homeostasis in Rats and Dogs: A Potential Cause of Drug Induced Liver Injury. Toxicol Sci. 2017;157(1):50-61.
180	Mechanistic investigations of the liver toxicity of the free fatty acid receptor 1 agonist fasiglifam (TAK875) and its primary metabolites. J Biochem Mol Toxicol. 2019 Aug;33(8):e22345.
181	Significant effect of polymorphisms in CYP2D6 and ABCC2 on clinical outcomes of adjuvant tamoxifen therapy for breast cancer patients. J Clin Oncol. 2010 Mar 10;28(8):1287-93.
182	Tanshinone IIA prevents acetaminophen-induced nephrotoxicity through the activation of the Nrf2-Mrp2/4 pathway in mice. Environ Toxicol. 2022;37(7):1618-1628.
183	Testing in vitro tools for the prediction of cholestatic liver injury induced by non-pharmaceutical chemicals. Food Chem Toxicol. 2021;152:112165.
184	Tumor necrosis factor-alpha-induced protein 3 as a putative regulator of nuclear factor-kappaB-mediated resistance to O6-alkylating agents in human glioblastomas. J Clin Oncol. 2006;24(2):274-87.
185	Chronic exposure of human glioblastoma tumors to low concentrations of a pesticide mixture induced multidrug resistance against chemotherapy agents. Ecotoxicol Environ Saf. 2020;202:110940.
186	The effect of oxidative stress upon the intestinal uptake of folic acid: in vitro studies with Caco-2 cells. Cell Biol Toxicol. 2012;28(6):369-81.
187	Theaflavin 3, 3'-Digallate Delays Ovarian Aging by Improving Oocyte Quality and Regulating Granulosa Cell Function. Oxid Med Cell Longev. 2021;2021:7064179.
188	Comparative case study on NAMs: towards enhancing specific target organ toxicity analysis. Arch Toxicol. 2024;98(11):3641-3658.
189	Primary Human Hepatocyte Spheroids as Tools to Study the Hepatotoxic Potential of Non-Pharmaceutical Chemicals. Int J Mol Sci. 2021;22(20).
190	Association between Organophosphate Ester Exposure and Insulin Resistance with Glycometabolic Disorders among Older Chinese Adults 60-69 Years of Age: Evidence from the China BAPE Study. Environ Health Perspect. 2023;131(4):47009.
191	Variable p53/Nrf2 crosstalk contributes to triptolide-induced hepatotoxic process. Toxicol Lett. 2023;379:67-75.
192	Construction of triple-transfected cells [organic anion-transporting polypeptide (OATP) 1B1/multidrug resistance-associated protein (MRP) 2/MRP3 and OATP1B1/MRP2/MRP4] for analysis of the sinusoidal function of MRP3 and MRP4. Drug Metab Dispos. 2009;37(10):2103-11.
193	Transport of the investigational anti-cancer drug 5,6-dimethylxanthenone-4-acetic acid and its acyl glucuronide by human intestinal Caco-2 cells. Eur J Pharm Sci. 2005;24(5):513-24.
194	Determination of the investigational anti-cancer drug 5,6-dimethylxanthenone-4-acetic acid and its acyl glucuronide in Caco-2 monolayers by liquid chromatography with fluorescence detection: application to transport studies. J Chromatogr B Analyt Technol Biomed Life Sci. 2004;809(1):87-97.
195	Effects of lithium and valproic acid on gene expression and phenotypic markers in an NT2 neurosphere model of neural development. PLoS One. 2013;8(3):e58822.
196	Novel tetrahydroisoquinolin-ethyl-phenylamine based multidrug resistance inhibitors with broad-spectrum modulating properties. Cancer Chemother Pharmacol. 2007;59(1):61-9.
197	ABCC1, ABCC2 and ABCC3 are implicated in the transepithelial transport of the myco-estrogen zearalenone and its major metabolites. Toxicol Lett. 2009;190(2):215-23.
198	Inhibition of Hepatobiliary Transport Activity by the Antibacterial Agent Fusidic Acid: Insights into Factors Contributing to Conjugated Hyperbilirubinemia/Cholestasis. Chem Res Toxicol. 2016 Oct 17;29(10):1778-1788.
199	Interactions between cyazofamid and human drug transporters. J Biochem Mol Toxicol. 2020;34(4):e22459.
200	Acute regulation of multidrug resistance-associated protein 2 localization and activity by cAMP and estradiol-17-D-glucuronide in rat intestine and Caco-2 cells. Arch Toxicol. 2018;92(2):777-788.
201	Substrates and inhibitors of efflux proteins interfere with the MTT assay in cells and may lead to underestimation of drug toxicity. Eur J Pharm Sci. 2004;23(2):181-8.
202	The role of efflux transporters on the transport of highly toxic aconitine, mesaconitine, hypaconitine, and their hydrolysates, as determined in cultured Caco-2 and transfected MDCKII cells. Toxicol Lett. 2013;216(2-3):86-99.
203	Interaction Studies of Resolvin E1 Analog (RX-10045) with Efflux Transporters. J Ocul Pharmacol Ther. 2015;31(4):248-55.
204	Reversal of in vitro cellular MRP1 and MRP2 mediated vincristine resistance by the flavonoid myricetin. Biochem Pharmacol. 2005;69(11):1657-65.
205	L-type calcium channel blockers reverse docetaxel and vincristine-induced multidrug resistance independent of ABCB1 expression in human lung cancer cell lines. Toxicol Lett. 2010 Feb 15;192(3):408-18.
206	Pharmacological inhibition of Rho-kinase (ROCK) signaling enhances cisplatin resistance in neuroblastoma cells. Int J Oncol. 2010;37(5):1297-305.
207	In vitro toxicological effects of estrogenic mycotoxins on human placental cells: structure activity relationships. Toxicol Appl Pharmacol. 2012;259(3):366-75.
208	Characterization of arsenic hepatobiliary transport using sandwich-cultured human hepatocytes. Toxicol Sci. 2015 Jun;145(2):307-20.

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