Detail Information of Exogenous Modulation

General Information of Drug Transporter (DT)
DT ID	DTD0257 Transporter Info
Gene Name	SLC2A2
Transporter Name	Glucose transporter type 2, liver
Gene ID	6514
UniProt ID	P11168

Exogenous factors (drugs, dietary constituents, etc.) Modulation of This DT (EGM)
Chemical Compound
DT Modulation1	NR1I2 protein promotes the reaction Rifampin results in decreased expression of SLC2A2 protein			[8]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Catechin inhibits the reaction Glucose results in decreased expression of SLC2A2 protein			[21]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Glucose inhibits the reaction SLC2A2 protein results in increased transport of Deoxyglucose			[38]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Glucose inhibits the reaction SLC2A2 protein results in increased transport of Fructose			[38]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Glucose results in increased expression of SLC2A2 mRNA			[43]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Plant Extracts inhibits the reaction Glucose results in decreased expression of SLC2A2 protein			[21]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	SLC2A2 protein results in increased transport of Glucose			[42]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Flame Retardants results in increased abundance of tris(1,3-dichloro-2-propyl)phosphate which results in decreased expression of SLC2A2 protein			[52]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Benzo(a)pyrene affects the methylation of SLC2A2 promoter			[34]
Regulation Mechanism				Transcription Factor Info
4-hydroxyisoleucine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	4-hydroxyisoleucine results in increased phosphorylation of SLC2A2 protein			[30]
Regulation Mechanism				Transcription Factor Info
5-iodotubercidin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	5-iodotubercidin results in increased expression of SLC2A2 mRNA			[31]
Regulation Mechanism				Transcription Factor Info
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction SIRT1 protein promotes the reaction Resveratrol results in increased expression of SLC2A2 mRNA			[18]
Regulation Mechanism				Transcription Factor Info
Acetylcysteine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Acetylcysteine inhibits the reaction Pyruvaldehyde affects the localization of SLC2A2 protein			[32]
Regulation Mechanism				Transcription Factor Info
Bezafibrate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Bezafibrate inhibits the reaction Oleic Acid results in increased expression of SLC2A2 mRNA			[35]
Regulation Mechanism				Transcription Factor Info
bisphenol A	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	bisphenol A affects the expression of SLC2A2 mRNA			[25]
Regulation Mechanism				Transcription Factor Info
caffeic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	caffeic acid results in increased expression of SLC2A2 mRNA			[28]
Regulation Mechanism				Transcription Factor Info
Catechin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Catechin inhibits the reaction Glucose results in decreased expression of SLC2A2 protein			[21]
Regulation Mechanism				Transcription Factor Info
CGP 52608	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	CGP 52608 promotes the reaction RORA protein binds to SLC2A2 gene			[36]
Regulation Mechanism				Transcription Factor Info
Chenodeoxycholic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tartrazine co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid results in decreased expression of SLC2A2 mRNA			[37]
Regulation Mechanism				Transcription Factor Info
Cytochalasin B	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cytochalasin B inhibits the reaction SLC2A2 protein results in increased transport of Deoxyglucose			[38]
Regulation Mechanism				Transcription Factor Info
Dehydroascorbic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLC2A2 protein results in increased uptake of Dehydroascorbic Acid			[39]
Regulation Mechanism				Transcription Factor Info
Deoxycholic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tartrazine co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid results in decreased expression of SLC2A2 mRNA			[37]
Regulation Mechanism				Transcription Factor Info
Deoxyglucose	5 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cytochalasin B inhibits the reaction SLC2A2 protein results in increased transport of Deoxyglucose			[38]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Fructose inhibits the reaction SLC2A2 protein results in increased transport of Deoxyglucose			[38]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Glucose inhibits the reaction SLC2A2 protein results in increased transport of Deoxyglucose			[38]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Maltose inhibits the reaction SLC2A2 protein results in increased transport of Deoxyglucose			[38]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	SLC2A2 protein results in increased transport of Deoxyglucose			[38]
Regulation Mechanism				Transcription Factor Info
dicrotophos	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	dicrotophos results in decreased expression of SLC2A2 mRNA			[23]
Regulation Mechanism				Transcription Factor Info
Diethylnitrosamine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Diethylnitrosamine results in decreased expression of SLC2A2 mRNA			[40]
Regulation Mechanism				Transcription Factor Info
Fructose	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Fructose inhibits the reaction SLC2A2 protein results in increased transport of Deoxyglucose			[38]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Glucose inhibits the reaction SLC2A2 protein results in increased transport of Fructose			[38]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Maltose inhibits the reaction SLC2A2 protein results in increased transport of Fructose			[38]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	SLC2A2 protein results in increased transport of Fructose			[42]
Regulation Mechanism				Transcription Factor Info
Galactose	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLC2A2 protein results in increased transport of Galactose			[38]
Regulation Mechanism				Transcription Factor Info
Glycochenodeoxycholic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tartrazine co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid results in decreased expression of SLC2A2 mRNA			[37]
Regulation Mechanism				Transcription Factor Info
Glycocholic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tartrazine co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid results in decreased expression of SLC2A2 mRNA			[37]
Regulation Mechanism				Transcription Factor Info
Glycodeoxycholic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tartrazine co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid results in decreased expression of SLC2A2 mRNA			[37]
Regulation Mechanism				Transcription Factor Info
hyperoside	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	hyperoside analog results in increased expression of SLC2A2 mRNA			[28]
Regulation Mechanism				Transcription Factor Info
indirubin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	indirubin results in decreased expression of SLC2A2 mRNA			[16]
Regulation Mechanism				Transcription Factor Info
Maltose	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Maltose inhibits the reaction SLC2A2 protein results in increased transport of Deoxyglucose			[38]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Maltose inhibits the reaction SLC2A2 protein results in increased transport of Fructose			[38]
Regulation Mechanism				Transcription Factor Info
methyleugenol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	methyleugenol results in decreased expression of SLC2A2 mRNA			[26]
Regulation Mechanism				Transcription Factor Info
Okadaic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Okadaic Acid results in decreased expression of SLC2A2 mRNA			[46]
Regulation Mechanism				Transcription Factor Info
Oleic Acid	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Bezafibrate inhibits the reaction Oleic Acid results in increased expression of SLC2A2 mRNA			[35]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Palmitic Acid co-treated with Oleic Acid results in decreased expression of SLC2A2 mRNA			[47]
Regulation Mechanism				Transcription Factor Info
Palmitic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Palmitic Acid co-treated with Oleic Acid results in decreased expression of SLC2A2 mRNA			[47]
Regulation Mechanism				Transcription Factor Info
perfluorooctane sulfonic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	perfluorooctane sulfonic acid results in decreased expression of SLC2A2 mRNA			[27]
Regulation Mechanism				Transcription Factor Info
Pyruvaldehyde	5 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Acetylcysteine inhibits the reaction Pyruvaldehyde affects the localization of SLC2A2 protein			[32]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	NFE2L2 protein affects the reaction Resveratrol inhibits the reaction Pyruvaldehyde affects the localization of SLC2A2 protein			[32]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Pyruvaldehyde affects the localization of SLC2A2 protein			[32]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Resveratrol inhibits the reaction Pyruvaldehyde affects the localization of SLC2A2 protein			[32]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Rosiglitazone inhibits the reaction Pyruvaldehyde affects the localization of SLC2A2 protein			[32]
Regulation Mechanism				Transcription Factor Info
Rosiglitazone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Rosiglitazone inhibits the reaction Pyruvaldehyde affects the localization of SLC2A2 protein			[32]
Regulation Mechanism				Transcription Factor Info
sodium arsenite	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	sodium arsenite results in decreased expression of SLC2A2 mRNA			[24]
Regulation Mechanism				Transcription Factor Info
Tartrazine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tartrazine co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid results in decreased expression of SLC2A2 mRNA			[37]
Regulation Mechanism				Transcription Factor Info
Tetrachlorodibenzodioxin	10 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	AHR protein promotes the reaction Tetrachlorodibenzodioxin results in decreased expression of SLC2A2 mRNA			[29]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	ARNT protein promotes the reaction Tetrachlorodibenzodioxin results in decreased expression of SLC2A2 mRNA			[29]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Endosulfan co-treated with Tetrachlorodibenzodioxin results in decreased expression of SLC2A2 mRNA			[41]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Endosulfan promotes the reaction Tetrachlorodibenzodioxin results in decreased expression of SLC2A2 mRNA			[29]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Tetrachlorodibenzodioxin affects the expression of SLC2A2 mRNA			[50]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Tetrachlorodibenzodioxin inhibits the reaction SRC protein results in increased expression of SLC2A2 mRNA			[29]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	Tetrachlorodibenzodioxin promotes the reaction ARNT protein results in decreased expression of SLC2A2 mRNA			[29]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	Tetrachlorodibenzodioxin promotes the reaction Endosulfan results in decreased expression of SLC2A2 mRNA			[29]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	Tetrachlorodibenzodioxin results in decreased expression of SLC2A2 mRNA			[16]
Regulation Mechanism				Transcription Factor Info
DT Modulation10	Tetrachlorodibenzodioxin results in decreased expression of SLC2A2 protein			[29]
Regulation Mechanism				Transcription Factor Info
tributyltin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	tributyltin results in increased expression of SLC2A2 mRNA			[51]
Regulation Mechanism				Transcription Factor Info
triphenyl phosphate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Flame Retardants results in increased abundance of triphenyl phosphate which results in decreased expression of SLC2A2 protein			[52]
Regulation Mechanism				Transcription Factor Info
Vanillic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Vanillic Acid inhibits the reaction INS protein results in decreased expression of SLC2A2 protein			[44]
Regulation Mechanism				Transcription Factor Info
Herbicide
Paraquat	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Paraquat inhibits the reaction SYT1 protein results in increased expression of SLC2A2 protein			[48]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Paraquat results in decreased expression of SLC2A2 protein			[48]
Regulation Mechanism				Transcription Factor Info
Nanoparticle
perfluoro-n-nonanoic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	perfluoro-n-nonanoic acid results in decreased expression of SLC2A2 mRNA			[27]
Regulation Mechanism				Transcription Factor Info
Approved Drug
Copper Sulfate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Copper Sulfate inhibits the expression of SLC2A2			[1]
Estradiol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Estradiol inhibits the expression of SLC2A2			[2]
Folic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Folic Acid inhibits the expression of SLC2A2			[3]
Hydrogen Peroxide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Hydrogen Peroxide inhibits the expression of SLC2A2			[4]
Arsenic Trioxide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Arsenic Trioxide increases the expression of SLC2A2			[5]
Azathioprine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Azathioprine inhibits the expression of SLC2A2			[6]
Methotrexate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Methotrexate increases the expression of SLC2A2			[7]
Atorvastatin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Atorvastatin inhibits the expression of SLC2A2			[8]
DT Modulation2	NR1I2 protein promotes the reaction Atorvastatin results in decreased expression of SLC2A2 protein			[8]
Regulation Mechanism				Transcription Factor Info
Urethane	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Urethane inhibits the expression of SLC2A2			[9]
Valproic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Valproic Acid inhibits the expression of SLC2A2			[10]
Calcitriol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Calcitriol inhibits the expression of SLC2A2			[11]
Cyclosporine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cyclosporine inhibits the expression of SLC2A2			[12]
Acetaminophen	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Acetaminophen inhibits the expression of SLC2A2			[13]
Rifampin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Rifampin inhibits the expression of SLC2A2			[14]
Pentoxifylline	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Pentoxifylline induces the activity of SLC2A2			[15]
Metformin	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Metformin inhibits the reaction INS protein results in decreased expression of SLC2A2 protein			[44]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Metformin results in increased phosphorylation of SLC2A2 protein			[30]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	SLC2A2 intron SNP results in increased susceptibility to Metformin			[45]
Regulation Mechanism				Transcription Factor Info
Drug in Phase 3 Trial
Resveratrol	5 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Resveratrol increases the expression of SLC2A2			[18]
Drug in Phase 2 Trial
Bisphenol A	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Bisphenol A affects the expression of SLC2A2			[25]
Drug in Phase 1 Trial
Quercetin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Quercetin inhibits the expression of SLC2A2			[19]
Sodium arsenite	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sodium arsenite inhibits the expression of SLC2A2			[24]
Drug in Preclinical Test
DT Modulation1	Oleic Acid increases the expression of SLC2A2			[54]
Regulation Mechanism	via enhancement of Peroxisome proliferator-activated receptor alpha (PPARA)			Transcription Factor Info
Affected Drug/Substrate	Insulin	Modulation Type	Inducer
Cell System	Human hepatoblastoma cells (HepG2)
Investigative Drug
Glucose	7 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Glucose inhibits the expression of SLC2A2			[21]
Natural Product
Indirubin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Indirubin inhibits the expression of SLC2A2			[16]
Coal Ash	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Coal Ash increases the expression of SLC2A2			[17]
DT Modulation1	6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction SIRT1 protein promotes the reaction Resveratrol results in increased expression of SLC2A2 mRNA			[18]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	NFE2L2 protein affects the reaction Resveratrol inhibits the reaction Pyruvaldehyde affects the localization of SLC2A2 protein			[32]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Resveratrol inhibits the reaction Pyruvaldehyde affects the localization of SLC2A2 protein			[32]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	SIRT1 protein promotes the reaction Resveratrol results in increased expression of SLC2A2 mRNA			[18]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Quercetin results in decreased activity of SLC2A2 protein			[49]
Regulation Mechanism				Transcription Factor Info
Phloretin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Phloretin inhibits the expression of SLC2A2			[8]
Methyleugenol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Methyleugenol inhibits the expression of SLC2A2			[26]
Hyperoside	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Hyperoside increases the expression of SLC2A2			[28]
Environmental toxicant
Polychlorinated dibenzodioxin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Polychlorinated dibenzodioxin inhibits the expression of SLC2A2			[29]
Mycotoxins
Aflatoxin B1	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Aflatoxin B1 inhibits the expression of SLC2A2			[20]
DT Modulation2	Aflatoxin B1 affects the expression of SLC2A2 protein			[2]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Aflatoxin B1 results in decreased methylation of SLC2A2 gene			[33]
Regulation Mechanism				Transcription Factor Info
Zearalenone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Zearalenone results in increased expression of SLC2A2 mRNA			[53]
Regulation Mechanism				Transcription Factor Info
Carcinogen
Benzo(a)pyrene	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Benzo(a)pyrene inhibits the expression of SLC2A2			[26]
Pesticide/Insecticide
Dicrotophos	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Dicrotophos inhibits the expression of SLC2A2			[23]
Endosulfan	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Endosulfan inhibits the expression of SLC2A2			[29]
Health and Environmental Toxicant
tris(1,3-dichloro-2-propyl)phosphate	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	tris(1,3-dichloro-2-propyl)phosphate inhibits the expression of SLC2A2			[22]
Perfluorooctane sulfonic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Perfluorooctane sulfonic acid inhibits the expression of SLC2A2			[27]
Caffeic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Caffeic acid increases the expression of SLC2A2			[28]
DT Modulation1	Endosulfan co-treated with Tetrachlorodibenzodioxin results in decreased expression of SLC2A2 mRNA			[41]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Endosulfan promotes the reaction Tetrachlorodibenzodioxin results in decreased expression of SLC2A2 mRNA			[29]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Tetrachlorodibenzodioxin promotes the reaction Endosulfan results in decreased expression of SLC2A2 mRNA			[29]
Regulation Mechanism				Transcription Factor Info

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11	Vitamin D3 transactivates the zinc and manganese transporter SLC30A10 via the Vitamin D receptor. J Steroid Biochem Mol Biol. 2016 Oct;163:77-87.
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14	Expression dynamics of pregnane X receptor-controlled genes in 3D primary human hepatocyte spheroids. Arch Toxicol. 2022 Jan;96(1):195-210.
15	Pentoxifylline aggravates fatty liver in obese and diabetic ob/ob mice by increasing intestinal glucose absorption and activating hepatic lipogenesis. Br J Pharmacol. 2012 Mar;165(5):1361-74.
16	Comparison of gene expression patterns between 2,3,7,8-tetrachlorodibenzo-p-dioxin and a natural arylhydrocarbon receptor ligand, indirubin. Toxicol Sci. 2004 Jul;80(1):161-9.
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