Detail Information of Exogenous Modulation

General Information of Drug Transporter (DT)
DT ID	DTD0028 Transporter Info
Gene Name	SLC47A2
Transporter Name	Multidrug and toxin extrusion protein 2
Gene ID	146802
UniProt ID	Q86VL8

Exogenous factors (drugs, dietary constituents, etc.) Modulation of This DT (EGM)
Chemical Compound
DT Modulation1	Quinine inhibits the reaction SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Cimetidine inhibits the reaction SLC47A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[23]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Cimetidine inhibits the reaction SLC47A2 protein results in increased uptake of Cadmium			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Amantadine inhibits the reaction SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Famotidine inhibits the reaction SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Procainamide analog inhibits the reaction SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Procainamide inhibits the reaction SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Ranitidine inhibits the reaction SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Verapamil inhibits the reaction SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Verapamil inhibits the reaction SLC47A2 protein results in increased uptake of Tetraethylammonium			[34]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Verapamil results in decreased activity of SLC47A2 protein			[5]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Estradiol co-treated with TGFB1 protein results in decreased expression of SLC47A2 mRNA			[27]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Estradiol promotes the reaction ESR2 protein affects the expression of SLC47A2 mRNA			[28]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Pyrimethamine analog inhibits the reaction SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Pyrimethamine inhibits the reaction SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Pyrimethamine inhibits the reaction SLC47A2 protein results in increased uptake of Tetraethylammonium			[12]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Pyrimethamine results in decreased activity of SLC47A2 protein			[12]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Ketoconazole inhibits the reaction SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Benzo(a)pyrene affects the methylation of SLC47A2 promoter			[24]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Amitriptyline inhibits the reaction SLC47A2 protein results in increased import of Tetraethylammonium			[5]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Pyrimethamine inhibits the reaction SLC47A2 protein results in increased uptake of Tetraethylammonium			[12]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	SLC47A2 protein results in increased import of Tetraethylammonium			[5]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	SLC47A2 protein results in increased uptake of Tetraethylammonium			[34]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Tetraethylammonium inhibits the reaction SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Tobacco Smoke Pollution inhibits the reaction SLC47A2 protein results in increased import of Tetraethylammonium			[5]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	Verapamil inhibits the reaction SLC47A2 protein results in increased uptake of Tetraethylammonium			[34]
Regulation Mechanism				Transcription Factor Info
1-Methyl-4-phenylpyridinium	51 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	1-Methyl-4-phenylpyridinium inhibits the reaction SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Agmatine inhibits the reaction SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Amantadine inhibits the reaction SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Amiloride inhibits the reaction SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Atropine inhibits the reaction SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Caffeine affects the reaction SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	Chloramphenicol affects the reaction SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	cinchonidine inhibits the reaction SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	cinchonine inhibits the reaction SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
DT Modulation10	Clonidine inhibits the reaction SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
DT Modulation11	Creatinine inhibits the reaction SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
DT Modulation12	ethohexadiol affects the reaction SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
DT Modulation13	Famotidine inhibits the reaction SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
DT Modulation14	Guanfacine inhibits the reaction SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
DT Modulation15	Guanidine affects the reaction SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
DT Modulation16	Histamine inhibits the reaction SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
DT Modulation17	Imiquimod inhibits the reaction SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
DT Modulation18	Ketoconazole inhibits the reaction SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
DT Modulation19	Metformin inhibits the reaction SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
DT Modulation20	Midodrine inhibits the reaction SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
DT Modulation21	Naloxone inhibits the reaction SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
DT Modulation22	Nialamide inhibits the reaction SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
DT Modulation23	Nicotinamide Mononucleotide inhibits the reaction SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
DT Modulation24	Nicotine inhibits the reaction SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
DT Modulation25	Paraquat inhibits the reaction SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
DT Modulation26	Phenformin inhibits the reaction SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
DT Modulation27	Phentolamine inhibits the reaction SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
DT Modulation28	Procainamide analog inhibits the reaction SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
DT Modulation29	Procainamide inhibits the reaction SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
DT Modulation30	Proguanil inhibits the reaction SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
DT Modulation31	Propranolol inhibits the reaction SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
DT Modulation32	Protons inhibits the reaction SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
DT Modulation33	Pyrimethamine analog inhibits the reaction SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
DT Modulation34	Pyrimethamine inhibits the reaction SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
DT Modulation35	Quinidine inhibits the reaction SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
DT Modulation36	Quinine inhibits the reaction SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
DT Modulation37	Ranitidine inhibits the reaction SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
DT Modulation38	Scopolamine inhibits the reaction SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
DT Modulation39	Serotonin inhibits the reaction SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
DT Modulation40	SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
DT Modulation41	Sulfadimethoxine affects the reaction SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
DT Modulation42	Sulfamerazine affects the reaction SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
DT Modulation43	Tacrine inhibits the reaction SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
DT Modulation44	Tetraethylammonium inhibits the reaction SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
DT Modulation45	Ticlopidine affects the reaction SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
DT Modulation46	Tramadol inhibits the reaction SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
DT Modulation47	Trichlormethiazide affects the reaction SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
DT Modulation48	triethylmethylammonium inhibits the reaction SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
DT Modulation49	Trimethoprim inhibits the reaction SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
DT Modulation50	Tyramine inhibits the reaction SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
DT Modulation51	Verapamil inhibits the reaction SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
2-palmitoylglycerol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	2-palmitoylglycerol results in increased expression of SLC47A2 mRNA			[21]
Regulation Mechanism				Transcription Factor Info
3-amino-1,4-dimethyl-5H-pyrido(4,3-b)indole	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	3-amino-1,4-dimethyl-5H-pyrido(4,3-b)indole results in decreased activity of SLC47A2 protein			[22]
Regulation Mechanism				Transcription Factor Info
3-amino-1-methyl-5H-pyrido(4,3-b)indole	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	3-amino-1-methyl-5H-pyrido(4,3-b)indole results in decreased activity of SLC47A2 protein			[22]
Regulation Mechanism				Transcription Factor Info
4-(4-dimethylaminostyryl)-1-methylpyridinium	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cimetidine inhibits the reaction SLC47A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[23]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Ondansetron inhibits the reaction SLC47A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[23]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	SLC47A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[23]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	zafirlukast inhibits the reaction SLC47A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[23]
Regulation Mechanism				Transcription Factor Info
Agmatine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Agmatine inhibits the reaction SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
Amiloride	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Amiloride inhibits the reaction SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
Amitriptyline	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Amitriptyline inhibits the reaction SLC47A2 protein results in increased import of Tetraethylammonium			[5]
Regulation Mechanism				Transcription Factor Info
Atropine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Atropine inhibits the reaction SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
bisphenol A	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	bisphenol A co-treated with Fulvestrant results in increased methylation of SLC47A2 gene			[25]
Regulation Mechanism				Transcription Factor Info
Chloramphenicol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Chloramphenicol affects the reaction SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
cinchonidine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	cinchonidine inhibits the reaction SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
cinchonine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	cinchonine inhibits the reaction SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
Clonidine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Clonidine inhibits the reaction SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
clothianidin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	clothianidin results in decreased activity of SLC47A2 protein			[19]
Regulation Mechanism				Transcription Factor Info
Creatinine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Creatinine inhibits the reaction SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
ethohexadiol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ethohexadiol affects the reaction SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
Fulvestrant	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	bisphenol A co-treated with Fulvestrant results in increased methylation of SLC47A2 gene			[25]
Regulation Mechanism				Transcription Factor Info
Guanfacine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Guanfacine inhibits the reaction SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
Guanidine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Guanidine affects the reaction SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
Histamine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Histamine inhibits the reaction SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
Imiquimod	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Imiquimod inhibits the reaction SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
Midodrine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Midodrine inhibits the reaction SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
Naloxone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Naloxone inhibits the reaction SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
Nialamide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Nialamide inhibits the reaction SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
Nicotinamide Mononucleotide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Nicotinamide Mononucleotide inhibits the reaction SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
Nicotine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Nicotine inhibits the reaction SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
NVP-BKM120	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	sotorasib co-treated with trametinib co-treated with NVP-BKM120 results in increased expression of SLC47A2 mRNA			[31]
Regulation Mechanism				Transcription Factor Info
Okadaic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Okadaic Acid results in decreased expression of SLC47A2 mRNA			[32]
Regulation Mechanism				Transcription Factor Info
Ondansetron	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ondansetron inhibits the reaction SLC47A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[23]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Ondansetron inhibits the reaction SLC47A2 protein results in increased uptake of Metformin			[29]
Regulation Mechanism				Transcription Factor Info
Phenformin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Phenformin inhibits the reaction SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
Phentolamine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Phentolamine inhibits the reaction SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
Proguanil	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Proguanil inhibits the reaction SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
Propranolol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Propranolol inhibits the reaction SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
Quinidine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Quinidine inhibits the reaction SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
Scopolamine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Scopolamine inhibits the reaction SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
Serotonin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Serotonin inhibits the reaction SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
Silicon Dioxide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Silicon Dioxide analog results in decreased expression of SLC47A2 mRNA			[33]
Regulation Mechanism				Transcription Factor Info
sotorasib	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	sotorasib co-treated with trametinib co-treated with NVP-BKM120 results in increased expression of SLC47A2 mRNA			[31]
Regulation Mechanism				Transcription Factor Info
Sulfadimethoxine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sulfadimethoxine affects the reaction SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
Sulfamerazine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sulfamerazine affects the reaction SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
Tacrine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tacrine inhibits the reaction SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
Tetrachlorodibenzodioxin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tetrachlorodibenzodioxin results in increased expression of SLC47A2 mRNA			[9]
Regulation Mechanism				Transcription Factor Info
Ticlopidine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ticlopidine affects the reaction SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
titanium dioxide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	titanium dioxide results in decreased expression of SLC47A2 mRNA			[14]
Regulation Mechanism				Transcription Factor Info
Tramadol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tramadol inhibits the reaction SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
trametinib	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	sotorasib co-treated with trametinib co-treated with NVP-BKM120 results in increased expression of SLC47A2 mRNA			[31]
Regulation Mechanism				Transcription Factor Info
Trichlormethiazide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Trichlormethiazide affects the reaction SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
triethylmethylammonium	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	triethylmethylammonium inhibits the reaction SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
Trimethoprim	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Trimethoprim inhibits the reaction SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
Tyramine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tyramine inhibits the reaction SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
Valproic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Valproic Acid results in increased methylation of SLC47A2 gene			[35]
Regulation Mechanism				Transcription Factor Info
zafirlukast	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	zafirlukast inhibits the reaction SLC47A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[23]
Regulation Mechanism				Transcription Factor Info
Herbicide
Paraquat	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Paraquat inhibits the reaction SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
Approved Drug
Quinine	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Quinine inhibits the transportation of 1-methyl-4-phenylpyridinium by SLC47A2 (IC50 = 6.4 microM)			[1]
Affected Drug/Substrate	1-methyl-4-phenylpyridinium	Modulation Type	Inhibition
Cell System	Chinese hamster ovary (CHO) cells-MATE2
DT Modulation2	Quinine inhibits the transportation of Tetraethylammonium by SLC47A2 (Ki = 23.1 microM)			[2]
Affected Drug/Substrate	Tetraethylammonium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MATE2
Cimetidine	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cimetidine inhibits the transportation of Tetraethylammonium by SLC47A2 (Ki = 7.3 microM)			[2]
Affected Drug/Substrate	Tetraethylammonium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MATE2
DT Modulation2	Cimetidine inhibits the transportation of Tetraethylammonium by SLC47A2 (Ki = 2.1 microM)			[3]
Affected Drug/Substrate	Tetraethylammonium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MATE2
Amantadine	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Amantadine inhibits the transportation of Tetraethylammonium by SLC47A2 (Ki = 1167 microM)			[2]
Affected Drug/Substrate	Tetraethylammonium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MATE2
Cetirizine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cetirizine inhibits the transportation of Tetraethylammonium by SLC47A2 (Ki = 817.6 microM)			[2]
Affected Drug/Substrate	Tetraethylammonium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MATE2
Chlorpheniramine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Chlorpheniramine inhibits the transportation of Tetraethylammonium by SLC47A2 (Ki = 191.2 microM)			[2]
Affected Drug/Substrate	Tetraethylammonium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MATE2
Desipramine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Desipramine inhibits the transportation of Tetraethylammonium by SLC47A2 (Ki = 283 microM)			[2]
Affected Drug/Substrate	Tetraethylammonium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MATE2
Diltiazem	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Diltiazem inhibits the transportation of Tetraethylammonium by SLC47A2 (Ki = 117 microM)			[2]
Affected Drug/Substrate	Tetraethylammonium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MATE2
Diphenhydramine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Diphenhydramine inhibits the transportation of Tetraethylammonium by SLC47A2 (Ki = 266.5 microM)			[2]
Affected Drug/Substrate	Tetraethylammonium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MATE2
Disopyramide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Disopyramide inhibits the transportation of Tetraethylammonium by SLC47A2 (Ki = 291.6 microM)			[2]
Affected Drug/Substrate	Tetraethylammonium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MATE2
Famotidine	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Famotidine inhibits the transportation of Tetraethylammonium by SLC47A2 (Ki = 9.7 microM)			[2]
Affected Drug/Substrate	Tetraethylammonium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MATE2
Imipramine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Imipramine inhibits the transportation of Tetraethylammonium by SLC47A2 (Ki = 182.9 microM)			[2]
Affected Drug/Substrate	Tetraethylammonium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MATE2
Metformin	5 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Metformin inhibits the transportation of Tetraethylammonium by SLC47A2 (Ki = 6515.7 microM)			[2]
Affected Drug/Substrate	Tetraethylammonium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MATE2
DT Modulation2	Cadmium inhibits the reaction SLC47A2 protein results in increased uptake of Metformin			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Metformin inhibits the reaction SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Ondansetron inhibits the reaction SLC47A2 protein results in increased uptake of Metformin			[29]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	SLC47A2 protein results in increased uptake of Metformin			[1]
Regulation Mechanism				Transcription Factor Info
Pramipexole	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Pramipexole inhibits the transportation of Tetraethylammonium by SLC47A2 (Ki = 24.1 microM)			[2]
Affected Drug/Substrate	Tetraethylammonium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MATE2
Procainamide	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Procainamide inhibits the transportation of Tetraethylammonium by SLC47A2 (Ki = 178.1 microM)			[2]
Affected Drug/Substrate	Tetraethylammonium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MATE2
Ranitidine	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ranitidine inhibits the transportation of Tetraethylammonium by SLC47A2 (Ki = 25 microM)			[2]
Affected Drug/Substrate	Tetraethylammonium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MATE2
Verapamil	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Verapamil inhibits the transportation of Tetraethylammonium by SLC47A2 (Ki = 32.1 microM)			[2]
Affected Drug/Substrate	Tetraethylammonium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MATE2
Carvedilol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Carvedilol inhibits the activity of SLC47A2 (IC50 = 202 microM)			[6]
Cell System	Human embryonic kidney 293 cells (HEK293)-MATE2
Cobicistat	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cobicistat inhibits the activity of SLC47A2 (IC50 = 3.2 microM)			[7]
Ritonavir	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ritonavir inhibits the activity of SLC47A2 (IC50 = 90 microM)			[7]
Cyclosporine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cyclosporine inhibits the expression of SLC47A2			[9]
Estradiol	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Estradiol increases the expression of SLC47A2			[10]
Acetaminophen	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Acetaminophen inhibits the expression of SLC47A2			[11]
Pyrimethamine	5 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Pyrimethamine inhibits the activity of SLC47A2			[12]
Cannabidiol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cannabidiol inhibits the expression of SLC47A2			[13]
Titanium dioxide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Titanium dioxide inhibits the expression of SLC47A2			[14]
Plazomicin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Plazomicin inhibits the activity of SLC47A2			[15]
Itraconazole	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Itraconazole inhibits the activity of SLC47A2			[16]
Ketoconazole	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ketoconazole inhibits the activity of SLC47A2			[16]
Drug in Phase 4 Trial
Talipexole	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Talipexole inhibits the transportation of Tetraethylammonium by SLC47A2 (Ki = 119.5 microM)			[2]
Affected Drug/Substrate	Tetraethylammonium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MATE2
Drug in Phase 2 Trial
Genistein	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Genistein increases the expression of SLC47A2			[10]
Discontinued Drug
DX-619	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	DX-619 inhibits the transportation of Creatinine by SLC47A2 (Ki = 0.1 microM)			[4]
Affected Drug/Substrate	Creatinine	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MATE2
Investigative Drug
Tetraethylammonium	8 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tetraethylammonium modulates the activity of SLC47A2			[20]
Natural Product
Cigarette smoke condensate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cigarette smoke condensate inhibits the activity of SLC47A2 (IC50 = 61.4 microM)			[5]
Cell System	Human embryonic kidney 293 cells (HEK293)-MATE2
Green tea	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Green tea inhibits the transportation of Metformin by SLC47A2			[8]
Affected Drug/Substrate	Metformin	Modulation Type	Inhibition
Cell System	Human enterocyte-like 2 cell (Caco-2)-MATE2
Tobacco Smoke Pollution	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tobacco Smoke Pollution inhibits the activity of SLC47A2			[5]
Caffeine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Caffeine affects the reaction SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[1]
Regulation Mechanism				Transcription Factor Info
Environmental toxicant
Polychlorinated dibenzodioxin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Polychlorinated dibenzodioxin increases the expression of SLC47A2			[9]
Carcinogen
Benzo(a)pyrene	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Benzo(a)pyrene increases the expression of SLC47A2			[9]
Cadmium	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cadmium inhibits the reaction SLC47A2 protein results in increased uptake of Metformin			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Cimetidine inhibits the reaction SLC47A2 protein results in increased uptake of Cadmium			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	SLC47A2 protein results in increased susceptibility to Cadmium			[26]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	SLC47A2 protein results in increased uptake of Cadmium			[26]
Regulation Mechanism				Transcription Factor Info
Nickel	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Nickel results in increased expression of SLC47A2 mRNA			[30]
Regulation Mechanism				Transcription Factor Info
Pesticide/Insecticide
Clothianidin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Clothianidin inhibits the activity of SLC47A2			[19]
Health and Environmental Toxicant
Lead	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Lead affects the expression of SLC47A2			[17]
Diethylhexyl Phthalate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Diethylhexyl Phthalate inhibits the expression of SLC47A2			[18]

References
1	Molecular determinants of ligand selectivity for the human multidrug and toxin extruder proteins MATE1 and MATE2-K. J Pharmacol Exp Ther. 2012 Jun;341(3):743-55.
2	Involvement of human multidrug and toxin extrusion 1 in the drug interaction between cimetidine and metformin in renal epithelial cells. J Pharmacol Exp Ther. 2009 Apr;329(1):185-91.
3	Competitive inhibition of the luminal efflux by multidrug and toxin extrusions, but not basolateral uptake by organic cation transporter 2, is the likely mechanism underlying the pharmacokinetic drug-drug interactions caused by cimetidine in the kidney. J Pharmacol Exp Ther. 2012 Feb;340(2):393-403.
4	Prediction of fluoroquinolone-induced elevation in serum creatinine levels: a case of drug-endogenous substance interaction involving the inhibition of renal secretion. Clin Pharmacol Ther. 2011 Jan;89(1):81-8.
5	Inhibition of organic anion transporter (OAT) activity by cigarette smoke condensate. Toxicol In Vitro. 2017 Oct;44:27-35.
6	Selective Inhibition on Organic Cation Transporters by Carvedilol Protects Mice from Cisplatin-Induced Nephrotoxicity. Pharm Res. 2018 Sep 6;35(11):204.
7	No Inhibition of MATE1/2K-Mediated Renal Creatinine Secretion Predicted With Ritonavir or Cobicistat. J Pharm Sci. 2019 Apr 26. pii: S0022-3549(19)30289-8.
8	Inhibitory Effects of Green Tea and (-)-Epigallocatechin Gallate on Transport by OATP1B1, OATP1B3, OCT1, OCT2, MATE1, MATE2-K and P-Glycoprotein. PLoS One. 2015 Oct 1;10(10):e0139370.
9	Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
10	Genistein and bisphenol A exposure cause estrogen receptor 1 to bind thousands of sites in a cell type-specific manner. Genome Res. 2012 Nov;22(11):2153-62.
11	Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans. Arch Toxicol. 2018 Feb;92(2):845-858.
12	Interactions between Oroxylin A with the solute carrier transporters and ATP-binding cassette transporters: Drug transporters profile for this flavonoid. Chem Biol Interact. 2020 Jun 1;324:109097.
13	Cannabidiol enhances cytotoxicity of anti-cancer drugs in human head and neck squamous cell carcinoma. Sci Rep. 2020 Nov 26;10(1):20622.
14	Genome-wide DNA methylome and transcriptome changes induced by inorganic nanoparticles in human kidney cells after chronic exposure. Cell Biol Toxicol. 2022 Jan 1.
15	No Effect of Plazomicin on the Pharmacokinetics of Metformin in Healthy Subjects. Clin Pharmacol Drug Dev. 2019 Jan 3.
16	Evaluation of Ketoconazole and Its Alternative Clinical CYP3A4/5 Inhibitors as Inhibitors of Drug Transporters: The In Vitro Effects of Ketoconazole, Ritonavir, Clarithromycin, and Itraconazole on 13 Clinically-Relevant Drug Transporters. Drug Metab Dispos. 2016 Mar;44(3):453-9.
17	RNA-Seq of Human Neural Progenitor Cells Exposed to Lead (Pb) Reveals Transcriptome Dynamics, Splicing Alterations and Disease Risk Associations. Toxicol Sci. 2017 Sep 1;159(1):251-265.
18	Di-(2-ethylhexyl)-phthalate induces apoptosis via the PPAR Gamma/PTEN/AKT pathway in differentiated human embryonic stem cells. Food Chem Toxicol. 2019 Sep;131:110552.
19	Neonicotinoid pesticides poorly interact with human drug transporters. J Biochem Mol Toxicol. 2019 Oct;33(10):e22379.
20	Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H(+)-organic cation antiporters. Biochem Pharmacol. 2007 Jul 15;74(2):359-71.
21	Direct effect of 2-palmitoyl glycerol on promotion of gamma aminobutyric acid synthesis in normal human fetal-derived astrocytes. FEBS Open Bio. 2023;13(7):1320-1332.
22	Inhibition of organic cation transporter (OCT) activities by carcinogenic heterocyclic aromatic amines. Toxicol In Vitro. 2019 Feb;54:10-22.
23	Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2. J Med Chem. 2011 Jul 14;54(13):4548-58.
24	Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017;8(1):1369-1391.
25	DNA methylome-wide alterations associated with estrogen receptor-dependent effects of bisphenols in breast cancer. Clin Epigenetics. 2019;11(1):138.
26	Multidrug and toxin extrusion proteins mediate cellular transport of cadmium. Toxicol Appl Pharmacol. 2017;314:55-62.
27	Transforming growth factor beta1 targets estrogen receptor signaling in bronchial epithelial cells. Respir Res. 2018 Aug 30;19(1):160.
28	Estrogen receptor beta binds to and regulates three distinct classes of target genes. J Biol Chem. 2010;285(29):22059-66.
29	Ondansetron can enhance cisplatin-induced nephrotoxicity via inhibition of multiple toxin and extrusion proteins (MATEs). Toxicol Appl Pharmacol. 2013;273(1):100-9.
30	Molecular profiling of contact dermatitis skin identifies allergen-dependent differences in immune response. J Allergy Clin Immunol. 2014;134(2):362-72.
31	Inhibition of KRAS, MEK and PI3K Demonstrate Synergistic Anti-Tumor Effects in Pancreatic Ductal Adenocarcinoma Cell Lines. Cancers (Basel). 2022;14(18).
32	A multi-omics approach to elucidate okadaic acid-induced changes in human HepaRG hepatocarcinoma cells. Arch Toxicol. 2024;98(9):2919-2935.
33	High-throughput, quantitative assessment of the effects of low-dose silica nanoparticles on lung cells: grasping complex toxicity with a great depth of field. BMC Genomics. 2015;16(1):315.
34	Inhibition of SLC drug transporter activities by environmental bisphenols. Toxicol In Vitro. 2017 Apr;40:34-44.
35	Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.

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