Detail Information of Exogenous Modulation

General Information of Drug Transporter (DT)
DT ID	DTD0025 Transporter Info
Gene Name	SLC22A8
Transporter Name	Organic anion transporter 3
Gene ID	9376
UniProt ID	Q8TCC7

Exogenous factors (drugs, dietary constituents, etc.) Modulation of This DT (EGM)
Chemical Compound
DT Modulation1	Probenecid inhibits the reaction SLC22A8 protein affects the transport of Cimetidine			[76]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Probenecid inhibits the reaction SLC22A8 protein affects the transport of estrone sulfate			[72]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Probenecid inhibits the reaction SLC22A8 protein affects the transport of Famotidine			[76]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Probenecid inhibits the reaction SLC22A8 protein affects the transport of traumatic acid			[91]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Probenecid inhibits the reaction SLC22A8 protein results in increased import of 6-carboxyfluorescein			[36]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Probenecid inhibits the reaction SLC22A8 protein results in increased import of estrone sulfate			[36]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	Probenecid inhibits the reaction SLC22A8 protein results in increased uptake of 6-carboxyfluorescein			[65]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	Probenecid inhibits the reaction SLC22A8 protein results in increased uptake of 7-hydroxycoumarin glucuronide			[65]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	Probenecid inhibits the reaction SLC22A8 protein results in increased uptake of 7-hydroxycoumarin metabolite			[65]
Regulation Mechanism				Transcription Factor Info
DT Modulation10	Probenecid inhibits the reaction SLC22A8 protein results in increased uptake of estrone sulfate			[56]
Regulation Mechanism				Transcription Factor Info
DT Modulation11	Probenecid inhibits the reaction SLC22A8 protein results in increased uptake of methyl 2-(1-(5-fluoropentyl)-1H-indazole-3-carboxamide)-3,3-dimethylbutanoate metabolite			[92]
Regulation Mechanism				Transcription Factor Info
DT Modulation12	Probenecid inhibits the reaction SLC22A8 results in increased uptake of Aristolochic Acids which results in increased chemical synthesis of 7-(deoxyadenosin-N(6)-yl)aristolactam I			[67]
Regulation Mechanism				Transcription Factor Info
DT Modulation13	Probenecid inhibits the reaction SLC22A8 results in increased uptake of Aristolochic Acids which results in increased chemical synthesis of 7-(deoxyguanosin-N(2)-yl)aristolactam I			[67]
Regulation Mechanism				Transcription Factor Info
DT Modulation14	Probenecid results in decreased activity of SLC22A8 protein			[36]
Regulation Mechanism				Transcription Factor Info
DT Modulation15	Probenecid results in decreased expression of SLC22A8 mRNA			[93]
Regulation Mechanism				Transcription Factor Info
DT Modulation16	Probenecid results in decreased expression of SLC22A8 protein			[93]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Bumetanide inhibits the reaction SLC22A8 protein affects the transport of estrone sulfate			[72]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Furosemide inhibits the reaction SLC22A8 protein affects the transport of estrone sulfate			[72]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Novobiocin inhibits the reaction SLC22A8 protein results in increased uptake of 4-carboxyfluorescein			[64]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Diclofenac inhibits the reaction SLC22A8 protein affects the transport of estrone sulfate			[72]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Indomethacin inhibits the reaction SLC22A8 protein affects the transport of estrone sulfate			[72]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	SLC22A8 protein results in increased uptake of Cefazolin			[73]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Cephaloridine inhibits the reaction SLC22A8 protein results in increased uptake of estrone sulfate			[73]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	SLC22A8 protein results in increased uptake of Cephaloridine			[73]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Cimetidine inhibits the reaction SLC22A8 protein affects the transport of estrone sulfate			[75]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Probenecid inhibits the reaction SLC22A8 protein affects the transport of Cimetidine			[76]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	SLC22A8 protein affects the transport of Cimetidine			[72]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	SLC22A8 protein results in increased uptake of Cimetidine			[76]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Valsartan results in increased expression of SLC22A8 protein			[97]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Cefaclor inhibits the reaction SLC22A8 protein results in increased uptake of estrone sulfate			[73]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	SLC22A8 protein results in increased uptake of Cefaclor			[73]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Linoleic Acid results in decreased activity of SLC22A8 protein			[38]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Omeprazole results in decreased activity of SLC22A8 protein which results in decreased uptake of Indican			[83]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Lansoprazole results in decreased activity of SLC22A8 protein which results in decreased uptake of Indican			[83]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Toluene results in decreased methylation of SLC22A8 gene			[55]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine inhibits the reaction SLC22A8 protein results in increased import of 6-carboxyfluorescein			[36]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine promotes the reaction 2-amino-9H-pyrido(2,3-b)indole inhibits the reaction SLC22A8 protein results in increased import of 6-carboxyfluorescein			[36]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine promotes the reaction 2-amino-9H-pyrido(2,3-b)indole results in decreased activity of SLC22A8 protein			[36]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased activity of SLC22A8 protein			[36]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	2-amino-9H-pyrido(2,3-b)indole promotes the reaction 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine inhibits the reaction SLC22A8 protein results in increased import of 6-carboxyfluorescein			[36]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	2-amino-9H-pyrido(2,3-b)indole promotes the reaction 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased activity of SLC22A8 protein			[36]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Emodin results in decreased activity of SLC22A8 protein			[38]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Benzo(a)pyrene affects the methylation of SLC22A8 exon			[71]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Benzo(a)pyrene affects the methylation of SLC22A8 promoter			[71]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Benzo(a)pyrene results in decreased activity of SLC22A8 protein			[58]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Benzo(a)pyrene results in decreased methylation of SLC22A8 5' UTR			[71]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Benzo(a)pyrene results in increased methylation of SLC22A8 3' UTR			[71]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Luteolin results in decreased activity of SLC22A8 protein			[59]
Regulation Mechanism				Transcription Factor Info
2-amino-9H-pyrido(2,3-b)indole	6 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine promotes the reaction 2-amino-9H-pyrido(2,3-b)indole inhibits the reaction SLC22A8 protein results in increased import of 6-carboxyfluorescein			[36]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine promotes the reaction 2-amino-9H-pyrido(2,3-b)indole results in decreased activity of SLC22A8 protein			[36]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	2-amino-9H-pyrido(2,3-b)indole inhibits the reaction SLC22A8 protein results in increased import of 6-carboxyfluorescein			[36]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	2-amino-9H-pyrido(2,3-b)indole promotes the reaction 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine inhibits the reaction SLC22A8 protein results in increased import of 6-carboxyfluorescein			[36]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	2-amino-9H-pyrido(2,3-b)indole promotes the reaction 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased activity of SLC22A8 protein			[36]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	2-amino-9H-pyrido(2,3-b)indole results in decreased activity of SLC22A8 protein			[36]
Regulation Mechanism				Transcription Factor Info
3-amino-1-methyl-5H-pyrido(4,3-b)indole	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	3-amino-1-methyl-5H-pyrido(4,3-b)indole inhibits the reaction SLC22A8 protein results in increased import of 6-carboxyfluorescein			[36]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	3-amino-1-methyl-5H-pyrido(4,3-b)indole results in decreased activity of SLC22A8 protein			[36]
Regulation Mechanism				Transcription Factor Info
4-carboxyfluorescein	7 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Niclosamide inhibits the reaction SLC22A8 protein results in increased uptake of 4-carboxyfluorescein			[64]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Novobiocin inhibits the reaction SLC22A8 protein results in increased uptake of 4-carboxyfluorescein			[64]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	quercetin 3-O-glucuronide analog inhibits the reaction SLC22A8 protein results in increased transport of 4-carboxyfluorescein			[18]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	quercetin 3-O-glucuronide inhibits the reaction SLC22A8 protein results in increased transport of 4-carboxyfluorescein			[18]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	quercetin 3'-sulfate inhibits the reaction SLC22A8 protein results in increased transport of 4-carboxyfluorescein			[18]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	SLC22A8 protein results in increased transport of 4-carboxyfluorescein			[18]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	SLC22A8 protein results in increased uptake of 4-carboxyfluorescein			[64]
Regulation Mechanism				Transcription Factor Info
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction SLC22A8 protein results in increased uptake of estrone sulfate			[63]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in decreased activity of SLC22A8 protein			[59]
Regulation Mechanism				Transcription Factor Info
6-carboxyfluorescein	17 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine inhibits the reaction SLC22A8 protein results in increased import of 6-carboxyfluorescein			[36]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine promotes the reaction 2-amino-9H-pyrido(2,3-b)indole inhibits the reaction SLC22A8 protein results in increased import of 6-carboxyfluorescein			[36]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	2-amino-9H-pyrido(2,3-b)indole inhibits the reaction SLC22A8 protein results in increased import of 6-carboxyfluorescein			[36]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	2-amino-9H-pyrido(2,3-b)indole promotes the reaction 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine inhibits the reaction SLC22A8 protein results in increased import of 6-carboxyfluorescein			[36]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	3-amino-1-methyl-5H-pyrido(4,3-b)indole inhibits the reaction SLC22A8 protein results in increased import of 6-carboxyfluorescein			[36]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	7-hydroxycoumarin glucuronide inhibits the reaction SLC22A8 protein results in increased uptake of 6-carboxyfluorescein			[65]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	7-hydroxycoumarin inhibits the reaction SLC22A8 protein results in increased uptake of 6-carboxyfluorescein			[65]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	7-hydroxycoumarin metabolite inhibits the reaction SLC22A8 protein results in increased uptake of 6-carboxyfluorescein			[65]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	Cadmium Chloride promotes the reaction SLC22A8 protein results in increased import of 6-carboxyfluorescein			[36]
Regulation Mechanism				Transcription Factor Info
DT Modulation10	glutaric acid promotes the reaction SLC22A8 protein results in increased import of 6-carboxyfluorescein			[36]
Regulation Mechanism				Transcription Factor Info
DT Modulation11	lead chloride promotes the reaction SLC22A8 protein results in increased import of 6-carboxyfluorescein			[36]
Regulation Mechanism				Transcription Factor Info
DT Modulation12	Probenecid inhibits the reaction SLC22A8 protein results in increased import of 6-carboxyfluorescein			[36]
Regulation Mechanism				Transcription Factor Info
DT Modulation13	Probenecid inhibits the reaction SLC22A8 protein results in increased uptake of 6-carboxyfluorescein			[65]
Regulation Mechanism				Transcription Factor Info
DT Modulation14	SLC22A8 protein results in increased import of 6-carboxyfluorescein			[36]
Regulation Mechanism				Transcription Factor Info
DT Modulation15	SLC22A8 protein results in increased uptake of 6-carboxyfluorescein			[66]
Regulation Mechanism				Transcription Factor Info
DT Modulation16	sodium arsenate promotes the reaction SLC22A8 protein results in increased import of 6-carboxyfluorescein			[36]
Regulation Mechanism				Transcription Factor Info
DT Modulation17	Unithiol analog inhibits the reaction SLC22A8 protein results in increased uptake of 6-carboxyfluorescein			[66]
Regulation Mechanism				Transcription Factor Info
7-(deoxyadenosin-N(6)-yl)aristolactam I	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Probenecid inhibits the reaction SLC22A8 results in increased uptake of Aristolochic Acids which results in increased chemical synthesis of 7-(deoxyadenosin-N(6)-yl)aristolactam I			[67]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	SLC22A8 results in increased uptake of Aristolochic Acids which results in increased chemical synthesis of 7-(deoxyadenosin-N(6)-yl)aristolactam I			[67]
Regulation Mechanism				Transcription Factor Info
7-(deoxyguanosin-N(2)-yl)aristolactam I	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Probenecid inhibits the reaction SLC22A8 results in increased uptake of Aristolochic Acids which results in increased chemical synthesis of 7-(deoxyguanosin-N(2)-yl)aristolactam I			[67]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	SLC22A8 results in increased uptake of Aristolochic Acids which results in increased chemical synthesis of 7-(deoxyguanosin-N(2)-yl)aristolactam I			[67]
Regulation Mechanism				Transcription Factor Info
7-hydroxycoumarin	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	7-hydroxycoumarin inhibits the reaction SLC22A8 protein results in increased uptake of 6-carboxyfluorescein			[65]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	7-hydroxycoumarin metabolite inhibits the reaction SLC22A8 protein results in increased uptake of 6-carboxyfluorescein			[65]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Probenecid inhibits the reaction SLC22A8 protein results in increased uptake of 7-hydroxycoumarin metabolite			[65]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	SLC22A8 protein results in increased uptake of 7-hydroxycoumarin metabolite			[65]
Regulation Mechanism				Transcription Factor Info
7-hydroxycoumarin glucuronide	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	7-hydroxycoumarin glucuronide inhibits the reaction SLC22A8 protein results in increased uptake of 6-carboxyfluorescein			[65]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Probenecid inhibits the reaction SLC22A8 protein results in increased uptake of 7-hydroxycoumarin glucuronide			[65]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	SLC22A8 protein results in increased uptake of 7-hydroxycoumarin glucuronide			[65]
Regulation Mechanism				Transcription Factor Info
acetamiprid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	acetamiprid results in decreased activity of SLC22A8 protein			[57]
Regulation Mechanism				Transcription Factor Info
adefovir	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLC22A8 protein results in increased susceptibility to adefovir			[68]
Regulation Mechanism				Transcription Factor Info
aristolochic acid I	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	aristolochic acid I inhibits the reaction SLC22A8 results in increased uptake of estrone sulfate			[67]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	aristolochic acid I promotes the reaction SLC22A8 results in increased export of p-Aminohippuric Acid			[67]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	wedelolactone results in decreased activity of SLC22A8 protein which results in increased susceptibility to and results in increased activity of aristolochic acid I			[59]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	wogonin results in decreased activity of SLC22A8 protein which results in increased susceptibility to and results in increased activity of aristolochic acid I			[59]
Regulation Mechanism				Transcription Factor Info
aurantio-obtusin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	aurantio-obtusin results in decreased activity of SLC22A8 protein			[38]
Regulation Mechanism				Transcription Factor Info
bisphenol A	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	bisphenol A inhibits the reaction SLC22A8 protein results in increased uptake of estrone sulfate			[56]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	bisphenol A results in decreased activity of SLC22A8 protein			[56]
Regulation Mechanism				Transcription Factor Info
bisphenol F	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	bisphenol F inhibits the reaction SLC22A8 protein results in increased uptake of estrone sulfate			[56]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	bisphenol F results in decreased activity of SLC22A8 protein			[56]
Regulation Mechanism				Transcription Factor Info
bisphenol S	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	bisphenol S inhibits the reaction SLC22A8 protein results in increased uptake of estrone sulfate			[56]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	bisphenol S results in decreased activity of SLC22A8 protein			[56]
Regulation Mechanism				Transcription Factor Info
Cadmium Chloride	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cadmium Chloride promotes the reaction SLC22A8 protein results in increased import of 6-carboxyfluorescein			[36]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Cadmium Chloride results in increased activity of SLC22A8 protein			[36]
Regulation Mechanism				Transcription Factor Info
Cefdinir	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cefdinir inhibits the reaction SLC22A8 protein results in increased uptake of estrone sulfate			[73]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	SLC22A8 protein results in increased uptake of Cefdinir			[73]
Regulation Mechanism				Transcription Factor Info
cefoselis	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	cefoselis inhibits the reaction SLC22A8 protein results in increased uptake of estrone sulfate			[73]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	SLC22A8 protein results in increased uptake of cefoselis			[73]
Regulation Mechanism				Transcription Factor Info
Cefotiam	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cefotiam inhibits the reaction SLC22A8 protein results in increased uptake of estrone sulfate			[73]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	SLC22A8 protein results in increased uptake of Cefotiam			[73]
Regulation Mechanism				Transcription Factor Info
Ceftibuten	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ceftibuten inhibits the reaction SLC22A8 protein results in increased uptake of estrone sulfate			[73]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	SLC22A8 protein results in increased uptake of Ceftibuten			[73]
Regulation Mechanism				Transcription Factor Info
Ceftizoxime	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ceftizoxime inhibits the reaction SLC22A8 protein results in increased uptake of estrone sulfate			[73]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	SLC22A8 protein results in increased uptake of Ceftizoxime			[73]
Regulation Mechanism				Transcription Factor Info
Cephalosporins	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLC22A8 protein affects the secretion of Cephalosporins			[73]
Regulation Mechanism				Transcription Factor Info
CGP 52608	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	CGP 52608 promotes the reaction RORA protein binds to SLC22A8 gene			[74]
Regulation Mechanism				Transcription Factor Info
chrysophanic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	chrysophanic acid results in decreased activity of SLC22A8 protein			[38]
Regulation Mechanism				Transcription Factor Info
Cidofovir	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLC22A8 protein results in increased susceptibility to Cidofovir			[68]
Regulation Mechanism				Transcription Factor Info
Cisplatin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cisplatin results in decreased expression of SLC22A8 protein			[77]
Regulation Mechanism				Transcription Factor Info
clothianidin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	clothianidin results in decreased activity of SLC22A8 protein			[57]
Regulation Mechanism				Transcription Factor Info
cyazofamid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	cyazofamid inhibits the reaction SLC22A8 protein results in increased uptake of estrone sulfate			[78]
Regulation Mechanism				Transcription Factor Info
Cyclic AMP	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLC22A8 protein affects the transport of Cyclic AMP			[72]
Regulation Mechanism				Transcription Factor Info
daidzein	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLC22A8 protein results in increased uptake of daidzein analog			[18]
Regulation Mechanism				Transcription Factor Info
Dehydroepiandrosterone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Dehydroepiandrosterone inhibits the reaction SLC22A8 protein affects the transport of estrone sulfate			[72]
Regulation Mechanism				Transcription Factor Info
Dehydroepiandrosterone Sulfate	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLC22A8 protein affects the transport of Dehydroepiandrosterone Sulfate			[72]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	SLC22A8 protein results in increased uptake of Dehydroepiandrosterone Sulfate			[73]
Regulation Mechanism				Transcription Factor Info
Diazinon	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Diazinon results in increased methylation of SLC22A8 gene			[79]
Regulation Mechanism				Transcription Factor Info
Dinoprostone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLC22A8 protein affects the transport of Dinoprostone			[72]
Regulation Mechanism				Transcription Factor Info
dioscorealide B	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	dioscorealide B results in decreased activity of SLC22A8 protein			[59]
Regulation Mechanism				Transcription Factor Info
Enalaprilat	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLC22A8 protein results in increased uptake of Enalaprilat			[80]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	verlukast inhibits the reaction SLC22A8 protein results in increased uptake of Enalaprilat			[80]
Regulation Mechanism				Transcription Factor Info
estrone sulfate	36 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction SLC22A8 protein results in increased uptake of estrone sulfate			[63]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	aristolochic acid I inhibits the reaction SLC22A8 results in increased uptake of estrone sulfate			[67]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	bisphenol A inhibits the reaction SLC22A8 protein results in increased uptake of estrone sulfate			[56]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	bisphenol F inhibits the reaction SLC22A8 protein results in increased uptake of estrone sulfate			[56]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	bisphenol S inhibits the reaction SLC22A8 protein results in increased uptake of estrone sulfate			[56]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Bumetanide inhibits the reaction SLC22A8 protein affects the transport of estrone sulfate			[72]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	Cefaclor inhibits the reaction SLC22A8 protein results in increased uptake of estrone sulfate			[73]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	Cefdinir inhibits the reaction SLC22A8 protein results in increased uptake of estrone sulfate			[73]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	cefoselis inhibits the reaction SLC22A8 protein results in increased uptake of estrone sulfate			[73]
Regulation Mechanism				Transcription Factor Info
DT Modulation10	Cefotiam inhibits the reaction SLC22A8 protein results in increased uptake of estrone sulfate			[73]
Regulation Mechanism				Transcription Factor Info
DT Modulation11	Ceftibuten inhibits the reaction SLC22A8 protein results in increased uptake of estrone sulfate			[73]
Regulation Mechanism				Transcription Factor Info
DT Modulation12	Ceftizoxime inhibits the reaction SLC22A8 protein results in increased uptake of estrone sulfate			[73]
Regulation Mechanism				Transcription Factor Info
DT Modulation13	Cephaloridine inhibits the reaction SLC22A8 protein results in increased uptake of estrone sulfate			[73]
Regulation Mechanism				Transcription Factor Info
DT Modulation14	Cholates inhibits the reaction SLC22A8 protein affects the transport of estrone sulfate			[72]
Regulation Mechanism				Transcription Factor Info
DT Modulation15	Cimetidine inhibits the reaction SLC22A8 protein affects the transport of estrone sulfate			[75]
Regulation Mechanism				Transcription Factor Info
DT Modulation16	cyazofamid inhibits the reaction SLC22A8 protein results in increased uptake of estrone sulfate			[78]
Regulation Mechanism				Transcription Factor Info
DT Modulation17	Dehydroepiandrosterone inhibits the reaction SLC22A8 protein affects the transport of estrone sulfate			[72]
Regulation Mechanism				Transcription Factor Info
DT Modulation18	Diclofenac inhibits the reaction SLC22A8 protein affects the transport of estrone sulfate			[72]
Regulation Mechanism				Transcription Factor Info
DT Modulation19	estrone sulfate inhibits the reaction SLC22A8 protein results in increased uptake of Famotidine			[75]
Regulation Mechanism				Transcription Factor Info
DT Modulation20	estrone sulfate promotes the reaction SLC22A8 results in increased export of p-Aminohippuric Acid			[67]
Regulation Mechanism				Transcription Factor Info
DT Modulation21	Famotidine inhibits the reaction SLC22A8 protein affects the transport of estrone sulfate			[75]
Regulation Mechanism				Transcription Factor Info
DT Modulation22	Furosemide inhibits the reaction SLC22A8 protein affects the transport of estrone sulfate			[72]
Regulation Mechanism				Transcription Factor Info
DT Modulation23	Ibuprofen inhibits the reaction SLC22A8 protein affects the transport of estrone sulfate			[72]
Regulation Mechanism				Transcription Factor Info
DT Modulation24	Indomethacin inhibits the reaction SLC22A8 protein affects the transport of estrone sulfate			[72]
Regulation Mechanism				Transcription Factor Info
DT Modulation25	Probenecid inhibits the reaction SLC22A8 protein affects the transport of estrone sulfate			[72]
Regulation Mechanism				Transcription Factor Info
DT Modulation26	Probenecid inhibits the reaction SLC22A8 protein results in increased import of estrone sulfate			[36]
Regulation Mechanism				Transcription Factor Info
DT Modulation27	Probenecid inhibits the reaction SLC22A8 protein results in increased uptake of estrone sulfate			[56]
Regulation Mechanism				Transcription Factor Info
DT Modulation28	Quercetin inhibits the reaction SLC22A8 protein results in increased uptake of estrone sulfate			[81]
Regulation Mechanism				Transcription Factor Info
DT Modulation29	rhein inhibits the reaction SLC22A8 protein results in increased uptake of estrone sulfate			[82]
Regulation Mechanism				Transcription Factor Info
DT Modulation30	rhein metabolite inhibits the reaction SLC22A8 protein results in increased uptake of estrone sulfate			[82]
Regulation Mechanism				Transcription Factor Info
DT Modulation31	SLC22A8 protein affects the transport of estrone sulfate			[72]
Regulation Mechanism				Transcription Factor Info
DT Modulation32	SLC22A8 protein results in increased import of estrone sulfate			[36]
Regulation Mechanism				Transcription Factor Info
DT Modulation33	SLC22A8 protein results in increased uptake of estrone sulfate			[73]
Regulation Mechanism				Transcription Factor Info
DT Modulation34	SLC22A8 results in increased uptake of estrone sulfate			[67]
Regulation Mechanism				Transcription Factor Info
DT Modulation35	tetrabromobisphenol A inhibits the reaction SLC22A8 protein results in increased uptake of estrone sulfate			[56]
Regulation Mechanism				Transcription Factor Info
DT Modulation36	Tobacco Smoke Pollution inhibits the reaction SLC22A8 protein results in increased import of estrone sulfate			[36]
Regulation Mechanism				Transcription Factor Info
Famotidine	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	estrone sulfate inhibits the reaction SLC22A8 protein results in increased uptake of Famotidine			[75]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Famotidine inhibits the reaction SLC22A8 protein affects the transport of estrone sulfate			[75]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Probenecid inhibits the reaction SLC22A8 protein affects the transport of Famotidine			[76]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	SLC22A8 protein results in increased uptake of Famotidine			[75]
Regulation Mechanism				Transcription Factor Info
glutaric acid	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	glutaric acid promotes the reaction SLC22A8 protein results in increased import of 6-carboxyfluorescein			[36]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	glutaric acid results in increased activity of SLC22A8 protein			[36]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	SLC22A8 protein results in increased import of glutaric acid			[36]
Regulation Mechanism				Transcription Factor Info
glycitein	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLC22A8 protein results in increased uptake of glycitein analog			[18]
Regulation Mechanism				Transcription Factor Info
Indican	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Lansoprazole results in decreased activity of SLC22A8 protein which results in decreased uptake of Indican			[83]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Omeprazole results in decreased activity of SLC22A8 protein which results in decreased uptake of Indican			[83]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Pantoprazole results in decreased activity of SLC22A8 protein which results in decreased uptake of Indican			[83]
Regulation Mechanism				Transcription Factor Info
lead chloride	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	lead chloride promotes the reaction SLC22A8 protein results in increased import of 6-carboxyfluorescein			[36]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	lead chloride results in increased activity of SLC22A8 protein			[36]
Regulation Mechanism				Transcription Factor Info
Leucovorin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLC22A8 protein results in increased uptake of Leucovorin			[73]
Regulation Mechanism				Transcription Factor Info
Methotrexate	5 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Resveratrol inhibits the reaction SLC22A8 protein results in increased uptake of Methotrexate			[86]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	rhein metabolite inhibits the reaction SLC22A8 protein results in increased uptake of Methotrexate			[82]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	SLC22A8 protein affects the transport of Methotrexate			[72]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	SLC22A8 protein results in increased susceptibility to Methotrexate			[86]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	SLC22A8 protein results in increased uptake of Methotrexate			[73]
Regulation Mechanism				Transcription Factor Info
Niclosamide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Niclosamide inhibits the reaction SLC22A8 protein results in increased uptake of 4-carboxyfluorescein			[64]
Regulation Mechanism				Transcription Factor Info
obtusifolin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	obtusifolin results in decreased activity of SLC22A8 protein			[38]
Regulation Mechanism				Transcription Factor Info
p-Aminohippuric Acid	6 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	aristolochic acid I promotes the reaction SLC22A8 results in increased export of p-Aminohippuric Acid			[67]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	estrone sulfate promotes the reaction SLC22A8 results in increased export of p-Aminohippuric Acid			[67]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	SLC22A8 protein affects the transport of p-Aminohippuric Acid			[72]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	SLC22A8 protein results in increased uptake of p-Aminohippuric Acid			[73]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	SLC22A8 results in increased export of p-Aminohippuric Acid			[67]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Succinic Acid results in increased activity of SLC22A8 protein which results in increased uptake of p-Aminohippuric Acid			[87]
Regulation Mechanism				Transcription Factor Info
Pantoprazole	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Pantoprazole results in decreased activity of SLC22A8 protein which results in decreased uptake of Indican			[83]
Regulation Mechanism				Transcription Factor Info
penconazole	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	penconazole results in decreased activity of SLC22A8 protein			[88]
Regulation Mechanism				Transcription Factor Info
Penicillin G	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Resveratrol inhibits the reaction SLC22A8 protein results in increased uptake of Penicillin G			[86]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	SLC22A8 protein results in increased uptake of Penicillin G			[89]
Regulation Mechanism				Transcription Factor Info
perfluorohexanesulfonic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLC22A8 protein results in increased uptake of perfluorohexanesulfonic acid			[90]
Regulation Mechanism				Transcription Factor Info
perfluoro-n-heptanoic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLC22A8 protein results in increased uptake of perfluoro-n-heptanoic acid			[90]
Regulation Mechanism				Transcription Factor Info
perfluorooctanoic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLC22A8 protein results in increased uptake of perfluorooctanoic acid			[90]
Regulation Mechanism				Transcription Factor Info
quercetin 3-O-glucuronide	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	quercetin 3-O-glucuronide analog inhibits the reaction SLC22A8 protein results in increased transport of 4-carboxyfluorescein			[18]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	quercetin 3-O-glucuronide inhibits the reaction SLC22A8 protein results in increased transport of 4-carboxyfluorescein			[18]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	SLC22A8 protein results in increased uptake of quercetin 3-O-glucuronide analog			[18]
Regulation Mechanism				Transcription Factor Info
quercetin 3'-sulfate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	quercetin 3'-sulfate inhibits the reaction SLC22A8 protein results in increased transport of 4-carboxyfluorescein			[18]
Regulation Mechanism				Transcription Factor Info
Ranitidine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLC22A8 protein results in increased uptake of Ranitidine			[76]
Regulation Mechanism				Transcription Factor Info
rhein	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	rhein inhibits the reaction SLC22A8 protein results in increased uptake of estrone sulfate			[82]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	rhein metabolite inhibits the reaction SLC22A8 protein results in increased uptake of estrone sulfate			[82]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	rhein metabolite inhibits the reaction SLC22A8 protein results in increased uptake of Methotrexate			[82]
Regulation Mechanism				Transcription Factor Info
sodium arsenate	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	sodium arsenate promotes the reaction SLC22A8 protein results in increased import of 6-carboxyfluorescein			[36]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	sodium arsenate results in increased activity of SLC22A8 protein			[36]
Regulation Mechanism				Transcription Factor Info
Succinic Acid	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Succinic Acid results in increased activity of SLC22A8 protein			[87]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Succinic Acid results in increased activity of SLC22A8 protein which results in increased uptake of p-Aminohippuric Acid			[87]
Regulation Mechanism				Transcription Factor Info
Taurocholic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLC22A8 protein affects the transport of Taurocholic Acid			[72]
Regulation Mechanism				Transcription Factor Info
Tenofovir	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLC22A8 protein results in increased import of Tenofovir			[94]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	SLC22A8 protein results in increased susceptibility to Tenofovir			[68]
Regulation Mechanism				Transcription Factor Info
tetrabromobisphenol A	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	tetrabromobisphenol A inhibits the reaction SLC22A8 protein results in increased uptake of estrone sulfate			[56]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	tetrabromobisphenol A results in decreased activity of SLC22A8 protein			[56]
Regulation Mechanism				Transcription Factor Info
Tetracycline	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLC22A8 protein results in increased uptake of Tetracycline			[95]
Regulation Mechanism				Transcription Factor Info
thiacloprid	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	thiacloprid metabolite results in decreased activity of SLC22A8 protein			[57]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	thiacloprid results in decreased activity of SLC22A8 protein			[57]
Regulation Mechanism				Transcription Factor Info
traumatic acid	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Probenecid inhibits the reaction SLC22A8 protein affects the transport of traumatic acid			[91]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	SLC22A8 protein affects the transport of traumatic acid			[91]
Regulation Mechanism				Transcription Factor Info
uniconazole	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	uniconazole results in decreased activity of SLC22A8 protein			[88]
Regulation Mechanism				Transcription Factor Info
Unithiol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Unithiol analog inhibits the reaction SLC22A8 protein results in increased uptake of 6-carboxyfluorescein			[66]
Regulation Mechanism				Transcription Factor Info
Uric Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLC22A8 protein affects the transport of Uric Acid			[72]
Regulation Mechanism				Transcription Factor Info
Valproic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Valproic Acid results in increased methylation of SLC22A8 gene			[96]
Regulation Mechanism				Transcription Factor Info
verlukast	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	verlukast inhibits the reaction SLC22A8 protein results in increased uptake of Enalaprilat			[80]
Regulation Mechanism				Transcription Factor Info
wedelolactone	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	wedelolactone results in decreased activity of SLC22A8 protein			[59]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	wedelolactone results in decreased activity of SLC22A8 protein which results in increased susceptibility to and results in increased activity of aristolochic acid I			[59]
Regulation Mechanism				Transcription Factor Info
wogonin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	wogonin results in decreased activity of SLC22A8 protein			[59]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	wogonin results in decreased activity of SLC22A8 protein which results in increased susceptibility to and results in increased activity of aristolochic acid I			[59]
Regulation Mechanism				Transcription Factor Info
Nanoparticle
perfluoro-n-nonanoic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLC22A8 protein results in increased uptake of perfluoro-n-nonanoic acid			[90]
Regulation Mechanism				Transcription Factor Info
Fungicide
tebuconazole	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	tebuconazole results in decreased activity of SLC22A8 protein			[88]
Regulation Mechanism				Transcription Factor Info
Approved Drug
Probenecid	27 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Probenecid inhibits the transportation of Cimetidine by SLC22A8 (IC50 = 3.1 microM)			[1]
Affected Drug/Substrate	Cimetidine	Modulation Type	Inhibition
Cell System	Chinese hamster ovary (CHO) cells-OAT3
DT Modulation2	Probenecid inhibits the transportation of Dimesna by SLC22A8 (Ki = 32 microM)			[2]
Affected Drug/Substrate	Dimesna	Modulation Type	Inhibition
Cell System	Human cervical cancer cell line (Hela)-OAT3
DT Modulation3	Probenecid inhibits the transportation of Estrone sulfate by SLC22A8 (Ki = 9 microM)			[3]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT3
DT Modulation4	Probenecid inhibits the transportation of Fexofenadine by SLC22A8 (Ki = 1.3 microM)			[4]
Affected Drug/Substrate	Fexofenadine	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OAT3
DT Modulation5	Probenecid inhibits the transportation of Ochratoxin A by SLC22A8 (Ki = 4.41 microM)			[5]
Affected Drug/Substrate	Ochratoxin A	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT3
DT Modulation6	Probenecid inhibits the transportation of Sitagliptin by SLC22A8 (IC50 = 5.6 microM)			[1]
Affected Drug/Substrate	Sitagliptin	Modulation Type	Inhibition
Cell System	Chinese hamster ovary (CHO) cells-OAT3
DT Modulation7	Probenecid inhibits the transportation of Estrone sulfate by SLC22A8			[6]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OAT3
DT Modulation8	Probenecid inhibits the transportation of Fluorescein by SLC22A8			[7]
Affected Drug/Substrate	Fluorescein	Modulation Type	Inhibition
Cell System	Chinese hamster ovary (CHO) cells-OAT3
DT Modulation9	Probenecid inhibits the activity of SLC22A8			[1], [8]
DT Modulation10	Probenecid blocks the activity of SLC22A8			[9], [10]
DT Modulation11	Probenecid inhibits the activity of SLC22A8			[21]
Bumetanide	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Bumetanide inhibits the transportation of Estrone sulfate by SLC22A8 (IC50 = 0.75 microM)			[11]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT3
DT Modulation2	Bumetanide inhibits the transportation of Estrone sulfate by SLC22A8 (IC50 = 7.8 microM)			[13]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Oocytes-OAT3
DT Modulation3	Bumetanide inhibits the transportation of Methotrexate by SLC22A8 (IC50 = 5.4 microM)			[13]
Affected Drug/Substrate	Methotrexate	Modulation Type	Inhibition
Cell System	Oocytes-OAT3
Furosemide	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Furosemide inhibits the transportation of Estrone sulfate by SLC22A8 (IC50 = 7.31 microM)			[11]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT3
DT Modulation2	Furosemide inhibits the transportation of Sitagliptin by SLC22A8 (IC50 = 1.7 microM)			[1]
Affected Drug/Substrate	Sitagliptin	Modulation Type	Inhibition
Cell System	Chinese hamster ovary (CHO) cells-OAT3
DT Modulation3	Furosemide inhibits the activity of SLC22A8			[1], [16]
Ibuprofen	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ibuprofen inhibits the transportation of Estrone sulfate by SLC22A8 (IC50 = 6 microM)			[12]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT3
DT Modulation2	Ibuprofen inhibits the transportation of Sitagliptin by SLC22A8 (IC50 = 3.7 microM)			[1]
Affected Drug/Substrate	Sitagliptin	Modulation Type	Inhibition
Cell System	Chinese hamster ovary (CHO) cells-OAT3
DT Modulation3	Ibuprofen inhibits the activity of SLC22A8			[1], [16]
DT Modulation4	Ibuprofen inhibits the reaction SLC22A8 protein affects the transport of estrone sulfate			[72]
Regulation Mechanism				Transcription Factor Info
Cefadroxil	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cefadroxil inhibits the transportation of Prostaglandin F2alpha by SLC22A8 (Ki = 8620 microM)			[15]
Affected Drug/Substrate	Prostaglandin F2alpha	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT3
DT Modulation2	Cefadroxil inhibits the transportation of Fluorescein by SLC22A8			[7]
Affected Drug/Substrate	Fluorescein	Modulation Type	Inhibition
Cell System	Chinese hamster ovary (CHO) cells-OAT3
DT Modulation3	Cefadroxil inhibits the transportation of Estrone sulfate by SLC22A8			[7]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Piroxicam	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Piroxicam inhibits the transportation of Estrone sulfate by SLC22A8 (IC50 = 2.52 microM)			[12]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT3
DT Modulation2	Piroxicam inhibits the transportation of Ochratoxin A by SLC22A8 (Ki = 4.88 microM)			[5]
Affected Drug/Substrate	Ochratoxin A	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT3
Fluvastatin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Fluvastatin inhibits the transportation of Estrone sulfate by SLC22A8 (IC50 = 5.79 microM)			[19]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT3
DT Modulation2	Fluvastatin inhibits the activity of SLC22A8			[19]
Simvastatin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Simvastatin inhibits the transportation of Estrone sulfate by SLC22A8 (IC50 = 32.3 microM)			[19]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT3
DT Modulation2	Simvastatin inhibits the activity of SLC22A8			[19]
Sulfasalazine	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sulfasalazine inhibits the transportation of Methotrexate by SLC22A8 (IC50 = 3 microM)			[13]
Affected Drug/Substrate	Methotrexate	Modulation Type	Inhibition
Cell System	Oocytes-OAT3
DT Modulation2	Sulfasalazine inhibits the activity of SLC22A8			[13]
Gemfibrozil	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Gemfibrozil inhibits the transportation of Pravastatin by SLC22A8 (IC50 = 6.8 microM)			[20]
Affected Drug/Substrate	Pravastatin	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT3
DT Modulation2	Gemfibrozil inhibits the activity of SLC22A8			[22]
Sitagliptin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sitagliptin inhibits the transportation of Cimetidine by SLC22A8 (IC50 = 160 microM)			[1]
Affected Drug/Substrate	Cimetidine	Modulation Type	Inhibition
Cell System	Chinese hamster ovary (CHO) cells-OAT3
Betamipron	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Betamipron inhibits the transportation of Estrone sulfate by SLC22A8 (Ki = 48.3 microM)			[3]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT3
Cilastatin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cilastatin inhibits the transportation of Estrone sulfate by SLC22A8 (Ki = 231 microM)			[3]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT3
DT Modulation2	Cilastatin inhibits the uptake of diclofenac acyl glucuronide by SLC22A8			[32]
Affected Drug/Substrate	Diclofenac acyl glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OAT3
Acetazolamide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Acetazolamide inhibits the transportation of Estrone sulfate by SLC22A8 (IC50 = 816 microM)			[11]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT3
Chlorothiazide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Chlorothiazide inhibits the transportation of Estrone sulfate by SLC22A8 (IC50 = 65.3 microM)			[11]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT3
Cyclothiazide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cyclothiazide inhibits the transportation of Estrone sulfate by SLC22A8 (IC50 = 27.9 microM)			[11]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT3
Ethacrynic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ethacrynic acid inhibits the transportation of Estrone sulfate by SLC22A8 (IC50 = 0.58 microM)			[11]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT3
Hydrochlorothiazide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Hydrochlorothiazide inhibits the transportation of Estrone sulfate by SLC22A8 (IC50 = 942 microM)			[11]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT3
Methazolamide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Methazolamide inhibits the transportation of Estrone sulfate by SLC22A8 (IC50 = 97.5 microM)			[11]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT3
Trichlormethiazide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Trichloromethiazide inhibits the transportation of Estrone sulfate by SLC22A8 (IC50 = 71.2 microM)			[11]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT3
Novobiocin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Novobiocin inhibits the transportation of Estrone sulfate by SLC22A8 (IC50 = 4.99 microM; Ki = 4.77 microM)			[23]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Monkey kidney tissue Fibroblast-like cell lines (COS)7-OAT3
Diclofenac	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Diclofenac inhibits the transportation of Estrone sulfate by SLC22A8 (IC50 = 7.78 microM)			[12]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT3
Indomethacin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Indomethacin inhibits the transportation of Estrone sulfate by SLC22A8 (IC50 = 0.61 microM)			[12]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT3
Ketoprofen	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ketoprofen inhibits the transportation of Estrone sulfate by SLC22A8 (IC50 = 5.98 microM)			[12]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT3
Mefenamic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Mefenamic acid inhibits the transportation of Estrone sulfate by SLC22A8 (IC50 = 0.78 microM)			[12]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT3
Naproxen	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Naproxen inhibits the transportation of Estrone sulfate by SLC22A8 (IC50 = 4.67 microM)			[12]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT3
Sulindac	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sulindac inhibits the transportation of Estrone sulfate by SLC22A8 (IC50 = 3.62 microM)			[12]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT3
Pravastatin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Pravastatin inhibits the transportation of Estrone sulfate by SLC22A8 (IC50 = 13.7 microM)			[19]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT3
Phenylbutazone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Phenylbutazone inhibits the transportation of Methotrexate by SLC22A8 (Ki = 34.7 microM)			[14]
Affected Drug/Substrate	Methotrexate	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT3
Cefamandole	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cefamandole inhibits the transportation of Prostaglandin F2alpha by SLC22A8 (Ki = 50 microM)			[15]
Affected Drug/Substrate	Prostaglandin F2alpha	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT3
Cefazolin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cefazolin inhibits the transportation of Prostaglandin F2alpha by SLC22A8 (Ki = 550 microM)			[15]
Affected Drug/Substrate	Prostaglandin F2alpha	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT3
Cefoperazone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cefoperazone inhibits the transportation of Prostaglandin F2alpha by SLC22A8 (Ki = 1890 microM)			[15]
Affected Drug/Substrate	Prostaglandin F2alpha	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT3
Cefotaxime	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cefotaxime inhibits the transportation of Prostaglandin F2alpha by SLC22A8 (Ki = 290 microM)			[15]
Affected Drug/Substrate	Prostaglandin F2alpha	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT3
Ceftriaxone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ceftriaxone inhibits the transportation of Prostaglandin F2alpha by SLC22A8 (Ki = 4390 microM)			[15]
Affected Drug/Substrate	Prostaglandin F2alpha	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT3
Cephalothin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cephalothin inhibits the transportation of Prostaglandin F2alpha by SLC22A8 (Ki = 40 microM)			[15]
Affected Drug/Substrate	Prostaglandin F2alpha	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT3
Cimetidine	5 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cimetidine inhibits the transportation of Sitagliptin by SLC22A8 (IC50 = 79 microM)			[1]
Affected Drug/Substrate	Sitagliptin	Modulation Type	Inhibition
Cell System	Chinese hamster ovary (CHO) cells-OAT3
Fenofibric acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Fenofibric acid inhibits the transportation of Sitagliptin by SLC22A8 (IC50 = 2.2 microM)			[1]
Affected Drug/Substrate	Sitagliptin	Modulation Type	Inhibition
Cell System	Chinese hamster ovary (CHO) cells-OAT3
Indapamide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Indapamide inhibits the transportation of Sitagliptin by SLC22A8 (IC50 = 11 microM)			[1]
Affected Drug/Substrate	Sitagliptin	Modulation Type	Inhibition
Cell System	Chinese hamster ovary (CHO) cells-OAT3
Quinapril	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Quinapril inhibits the transportation of Sitagliptin by SLC22A8 (IC50 = 6.2 microM)			[1]
Affected Drug/Substrate	Sitagliptin	Modulation Type	Inhibition
Cell System	Chinese hamster ovary (CHO) cells-OAT3
Piperacillin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Piperacillin inhibits the transporation of tazobactam by SLC22A8 (IC50 = 89.04 microM; Ki = 172 microM)			[29]
Affected Drug/Substrate	Tazobactam	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)
Candesartan	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Candesartan inhibits the transportation of Uric acid by SLC22A8 (IC50 = 0.3 microM)			[30]
Affected Drug/Substrate	Uric acid	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OAT3
Losartan	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Losartan inhibits the transportation of Uric acid by SLC22A8 (IC50 = 1.6 microM)			[30]
Affected Drug/Substrate	Uric acid	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OAT3
Olmesartan medoxomil	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Olmesartan medoxomil inhibits the transportation of Uric acid by SLC22A8 (IC50 = 0.027 microM)			[30]
Affected Drug/Substrate	Uric acid	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OAT3
Telmisartan	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Telmisartan inhibits the transportation of Uric acid by SLC22A8 (IC50 = 1.6 microM)			[30]
Affected Drug/Substrate	Uric acid	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OAT3
Valsartan	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Valsartan inhibits the transportation of Uric acid by SLC22A8 (IC50 = 0.2 microM)			[30]
Affected Drug/Substrate	Uric acid	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OAT3
Imipenem	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Imipenem significantly inhibits the uptake of cilastatin by SLC22A8			[31]
Affected Drug/Substrate	Cilastatin	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OAT3
Zidovudine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Zidovudine inhibits the transportation of Estrone sulfate by SLC22A8			[33]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT3
Linagliptin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Linagliptin inhibits the transportation of Estrone sulfate by SLC22A8			[6]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OAT3
Carbenicillin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Carbenicillin inhibits the transportation of Fluorescein by SLC22A8			[7]
Affected Drug/Substrate	Fluorescein	Modulation Type	Inhibition
Cell System	Chinese hamster ovary (CHO) cells-OAT3
Cefaclor	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cefaclor inhibits the transportation of Fluorescein by SLC22A8			[7]
Affected Drug/Substrate	Fluorescein	Modulation Type	Inhibition
Cell System	Chinese hamster ovary (CHO) cells-OAT3
Dicloxacillin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Dicloxacillin inhibits the transportation of Fluorescein by SLC22A8			[7]
Affected Drug/Substrate	Fluorescein	Modulation Type	Inhibition
Cell System	Chinese hamster ovary (CHO) cells-OAT3
Oxacillin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Oxacillin inhibits the transportation of Fluorescein by SLC22A8			[7]
Affected Drug/Substrate	Fluorescein	Modulation Type	Inhibition
Cell System	Chinese hamster ovary (CHO) cells-OAT3
Aspirin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Aspirin inhibits the transportation of Cilostazol by SLC22A8			[34]
Affected Drug/Substrate	Cilostazol	Modulation Type	Inhibition
DT Modulation2	Aspirin results in increased expression of SLC22A8 mRNA			[70]
Regulation Mechanism				Transcription Factor Info
Bendroflumethiazide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Bendroflumethiazide inhibits the transportation of Polycyclic aromatic hydrocarbons by SLC22A8			[35]
Affected Drug/Substrate	Polycyclic aromatic hydrocarbons	Modulation Type	Inhibition
Folic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Folic Acid inhibits the expression of SLC22A8			[37]
Testosterone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Testosterone inhibits the expression of SLC22A8			[39]
Fluorescein	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Fluorescein inhibits the activity of SLC22A8			[40]
Ciprofloxacin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ciprofloxacin inhibits the activity of SLC22A8			[41]
Gatifloxacin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Gatifloxacin inhibits the activity of SLC22A8			[41]
Torasemide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Torsemide inhibits the activity of SLC22A8			[42]
Etoricoxib	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Etoricoxib inhibits the activity of SLC22A8			[43]
Celecoxib	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Celecoxib inhibits the activity of SLC22A8			[44], [45]
Rofecoxib	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Rofecoxib inhibits the activity of SLC22A8			[45]
Valdecoxib	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Valdecoxib inhibits the activity of SLC22A8			[45]
Vancomycin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Vancomycin inhibits the activity of SLC22A8			[46]
Sulfadiazine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sulfadiazine inhibits the activity of SLC22A8			[47]
Nitrofurantoin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Nitrofurantoin inhibits the activity of SLC22A8			[48]
Metronidazole	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Metronidazole inhibits the activity of SLC22A8			[49]
Selexipag	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Selexipag inhibits the activity of SLC22A8			[50]
Omeprazole	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Esomeprazole inhibits the activity of SLC22A8			[51]
Lansoprazole	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Lansoprazole inhibits the activity of SLC22A8			[51]
Itraconazole	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Itraconazole inhibits the activity of SLC22A8			[52]
Ketoconazole	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ketoconazole inhibits the activity of SLC22A8			[52]
Drug Marketed but not Approved by US FDA
Linoleic Acid	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Linoleic Acid inhibits the activity of SLC22A8			[38]
Drug in Phase 4 Trial
DT Modulation1	Benzylpenicillin inhibits the uptake of cilastatin by SLC22A8			[31]
Affected Drug/Substrate	Cilastatin	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OAT3
Dihydrotestosterone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Dihydrotestosterone induces the activity of SLC22A8			[61]
Drug in Phase 3 Trial
Benzylpenicillin	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Benzylpenicillin inhibits the transportation of Methotrexate by SLC22A8 (Ki = 97.6 microM)			[14]
Affected Drug/Substrate	Methotrexate	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT3
DT Modulation2	Benzylpenicillin inhibits the transportation of Fluorescein by SLC22A8			[7]
Affected Drug/Substrate	Fluorescein	Modulation Type	Inhibition
Cell System	Chinese hamster ovary (CHO) cells-OAT3
DT Modulation3	Benzylpenicillin inhibits the activity of SLC22A8			[17]
Pratosartan	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Pratosartan inhibits the transportation of Uric acid by SLC22A8 (IC50 = 0.095 microM)			[30]
Affected Drug/Substrate	Uric acid	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OAT3
Drug in Phase 2 Trial
Bisphenol A	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Bisphenol A inhibits the activity of SLC22A8			[56]
Drug in Phase 1/2 Trial
PRI-724	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	PRI-724 inhibits the activity of SLC22A8			[53]
Cell System	Human embryonic kidney 293 cells (HEK293)-
Drug in Phase 1 Trial
Luteolin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Luteolin inhibits the activity of SLC22A8			[59]
Quercetin	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Quercetin inhibits the activity of SLC22A8			[59]
Drug in Preclinical Test
Emodin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Emodin inhibits the activity of SLC22A8			[38]
Investigative Drug
Adipate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Adipate inhibits the transportation of Estrone sulfate by SLC22A8 (IC50 = 136 microM)			[24]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OAT3
Alpha-ketoglutaric acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Alpha-ketoglutaric acid inhibits the transportation of Estrone sulfate by SLC22A8 (IC50 = 92.8 microM)			[24]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OAT3
Glutarate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Glutarate inhibits the transportation of Estrone sulfate by SLC22A8 (IC50 = 78.5 microM)			[24]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OAT3
Aminohippuric acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Aminohippuric acid inhibits the transportation of Ochratoxin A by SLC22A8 (Ki = 19.6 microM)			[5]
Affected Drug/Substrate	Ochratoxin A	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT3
Angiotensinamide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Angiotensinamide inhibits the activity of SLC22A8			[62]
21H7	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	21H7 inhibits the activity of SLC22A8			[53]
Cell System	Human embryonic kidney 293 cells (HEK293)-
FH535	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	FH535 inhibits the activity of SLC22A8			[53]
Cell System	Human embryonic kidney 293 cells (HEK293)-
JBP485	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	JBP485 inhibits the uptake of imipenem by SLC22A6			[98]
Affected Drug/Substrate	Imipenem	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OAT3
Drug Withdrawn
Phenacetin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Phenacetin inhibits the transportation of Estrone sulfate by SLC22A8 (IC50 = 19.4 microM)			[12]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT3
Cephaloridine	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cephaloridine inhibits the transportation of Prostaglandin F2alpha by SLC22A8 (Ki = 2460 microM)			[15]
Affected Drug/Substrate	Prostaglandin F2alpha	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT3
Retigabine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ezogabine inhibits the activity of SLC22A8			[60]
Natural Product
Quercetin-3-O-glucuronide	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Quercetin-3-O-glucuronide inhibits the transportation of 5-carboxyfluorescein by SLC22A8 (IC50 = 1.31 microM)			[18]
Affected Drug/Substrate	5-carboxyfluorescein	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OAT3
DT Modulation2	Quercetin-3-O-glucuronide inhibits the transportation of 5-carboxyfluorescein by SLC22A8 (IC50 = 0.43 microM)			[18]
Affected Drug/Substrate	5-carboxyfluorescein	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OAT3
Quercetin-3-O-sulfate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Quercetin-3-O-sulfate inhibits the transportation of 5-carboxyfluorescein by SLC22A8 (IC50 = 0.75 microM)			[18]
Affected Drug/Substrate	5-carboxyfluorescein	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OAT3
Gallic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Gallic acid inhibits the transportation of Estrone sulfate by SLC22A8 (IC50 = 9 microM)			[25]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OAT3
Rosmarinic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Rosmarinic acid inhibits the transportation of Estrone sulfate by SLC22A8 (Ki= 0.55 microM)			[25]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OAT3
Ursolic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ursolic acid inhibits the transportation of Estrone sulfate by SLC22A8 (IC50 = 19 microM)			[25]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OAT3
Rhein	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Rhubarb inhibits the transportation of Estrone sulfate by SLC22A8 in a competitive manner (IC50 = 0.008 microM)			[26]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OAT3
Allethrin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Allethrin inhibits the transportation of Fluorescein by SLC22A8 (IC50 = 69.4 microM)			[27]
Affected Drug/Substrate	Fluorescein	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OAT3
Tetramethrin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tetramethrin inhibits the transportation of Fluorescein by SLC22A8 (IC50 = 77.6 microM)			[27]
Affected Drug/Substrate	Fluorescein	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OAT3
Citreoverdine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Citreoverdine inhibits the transportation of Organic anion by SLC22A8 (IC50 = 6.63 microM)			[28]
Affected Drug/Substrate	Organic anion	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT3
Cyclopiazonic acid	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cyclopiazonic acid inhibits the transportation of Organic anion by SLC22A8 (IC50 = 1.9 microM)			[28]
Affected Drug/Substrate	Organic anion	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT3
Fumonisin B1	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Fumonisin B1 inhibits the transportation of Organic anion by SLC22A8 (IC50 = 181 microM)			[28]
Affected Drug/Substrate	Organic anion	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT3
Daidzein-7-O-Glucuronide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Daidzein-7-O-Glucuronide inhibits the transportation of 5-carboxyfluorescein by SLC22A8			[18]
Affected Drug/Substrate	5-carboxyfluorescein	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OAT3
Genistein-7-O-glucuronide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Genistein-7-O-glucuronide inhibits the transportation of 5-carboxyfluorescein by SLC22A8			[18]
Affected Drug/Substrate	5-carboxyfluorescein	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OAT3
Glycitein-7-O-glucuronide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Glycitein-7-O-glucuronide inhibits the transportation of 5-carboxyfluorescein by SLC22A8			[18]
Affected Drug/Substrate	5-carboxyfluorescein	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OAT3
Cigarette smoke condensate (0.08mg/ml)	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cigarette smoke condensate (0.08mg/ml) inhibits the activity of SLC22A8			[36]
Cell System	Human embryonic kidney 293 cells (HEK293)-OAT3
Cigarette smoke condensate (0.32mg/ml)	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cigarette smoke condensate (0.32mg/ml) inhibits the activity of SLC22A8			[36]
Cell System	Human embryonic kidney 293 cells (HEK293)-OAT3
Tobacco Smoke Pollution	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tobacco Smoke Pollution inhibits the activity of SLC22A8			[36]
Chrysophanic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Chrysophanic acid inhibits the activity of SLC22A8			[38]
DT Modulation1	Quercetin inhibits the reaction SLC22A8 protein results in increased uptake of estrone sulfate			[81]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Quercetin results in decreased activity of SLC22A8 protein			[59]
Regulation Mechanism				Transcription Factor Info
Wogonin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Wogonin inhibits the activity of SLC22A8			[59]
Oroxylin A	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Oroxylin A inhibits the activity of SLC22A8 (IC50 = 0.112 microM)			[63]
Cell System	Human embryonic kidney 293 cells (HEK293)-SLC22A8
Resveratrol	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Resveratrol inhibits the reaction SLC22A8 protein results in increased uptake of Methotrexate			[86]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Resveratrol inhibits the reaction SLC22A8 protein results in increased uptake of Penicillin G			[86]
Regulation Mechanism				Transcription Factor Info
Dietary Constituent
Danshen	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Danshen inhibits the transportation of Estrone sulfate by SLC22A8 (Ki = 8.6 microM)			[25]
Affected Drug/Substrate	Estrone sulfate	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OAT3
Environmental toxicant
Bisphenol F	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Bisphenol F inhibits the activity of SLC22A8			[56]
Tetrabromobisphenol A	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tetrabromobisphenol A inhibits the activity of SLC22A8			[56]
Sodium arsenate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sodium arsenate increases the activity of SLC22A8			[36]
Mercury	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLC22A8 gene SNP affects the susceptibility to and affects the abundance of Mercury			[84]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	SLC22A8 gene SNP affects the susceptibility to Mercury which affects the abundance of Mercury			[85]
Regulation Mechanism				Transcription Factor Info
Mycotoxins
DT Modulation1	Cyclopiazonic acid inhibits the transportation of Organic anion by SLC22A8 (IC50 = 1.9 microM)			[28]
Affected Drug/Substrate	Organic anion	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT3
DT Modulation1	Fumonisin B1 inhibits the transportation of Organic anion by SLC22A8 (IC50 = 181 microM)			[28]
Affected Drug/Substrate	Organic anion	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT3
Aflatoxin B1	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Aflatoxin B1 inhibits the transportation of Organic anion by SLC22A8 (IC50 = 13.1 microM)			[28]
Affected Drug/Substrate	Organic anion	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT3
DT Modulation2	Aflatoxin B1 affects the methylation of SLC22A8 intron			[69]
Regulation Mechanism				Transcription Factor Info
Alpha-zearalenol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Alpha-zearalenol inhibits the transportation of Organic anion by SLC22A8 (IC50 = 4.55 microM)			[28]
Affected Drug/Substrate	Organic anion	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT3
Citrioveridine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Citrioveridine inhibits the transportation of Organic anion by SLC22A8 (IC50 = 6.63 microM)			[28]
Affected Drug/Substrate	Organic anion	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT3
Patulin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Patulin inhibits the transportation of Organic anion by SLC22A8 (IC50 > 1000 microM)			[28]
Affected Drug/Substrate	Organic anion	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT3
Gliotoxin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Gliotoxin inhibits the transportation of Organic anion by SLC22A8 (IC50 = 73.9 microM)			[28]
Affected Drug/Substrate	Organic anion	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT3
Zearalenone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Zearalenone inhibits the transportation of Organic anion by SLC22A8 (IC50 = 6.71 microM)			[28]
Affected Drug/Substrate	Organic anion	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT3
aflatoxin B2	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	aflatoxin B2 results in increased methylation of SLC22A8 intron			[69]
Regulation Mechanism				Transcription Factor Info
ochratoxin A	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLC22A8 protein affects the transport of ochratoxin A			[72]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	SLC22A8 protein results in increased uptake of ochratoxin A			[73]
Regulation Mechanism				Transcription Factor Info
Acute Toxic Substance
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine	7 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine inhibits the activity of SLC22A8			[36]
Carcinogen
Benzo(a)pyrene	6 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Benzo(a)pyrene inhibits the activity of SLC22A8			[58]
Pesticide/Insecticide
Clothianidin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Clothianidin inhibits the activity of SLC22A8			[57]
Imidacloprid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Imidacloprid inhibits the activity of SLC22A8			[57]
imidacloprid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	imidacloprid results in decreased activity of SLC22A8 protein			[57]
Regulation Mechanism				Transcription Factor Info
Health and Environmental Toxicant
Toluene	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Toluene increases the expression of SLC22A8			[55]
Lead chloride	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Lead chloride increases the activity of SLC22A8			[36]
Herbicide
Atrazine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Atrazine increases the expression of SLC22A8			[54]

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