Detail Information of Exogenous Modulation

General Information of Drug Transporter (DT)
DT ID	DTD0024 Transporter Info
Gene Name	SLC22A6
Transporter Name	Organic anion transporter 1
Gene ID	9356
UniProt ID	Q4U2R8

Exogenous factors (drugs, dietary constituents, etc.) Modulation of This DT (EGM)
Chemical Compound
DT Modulation1	Probenecid inhibits the reaction SLC22A6 protein affects the transport of traumatic acid			[89]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Probenecid inhibits the reaction SLC22A6 protein affects the transport of Uric Acid			[13]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Probenecid inhibits the reaction SLC22A6 protein results in increased import of 6-carboxyfluorescein			[42]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Probenecid inhibits the reaction SLC22A6 protein results in increased import of p-Aminohippuric Acid			[42]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Probenecid inhibits the reaction SLC22A6 protein results in increased susceptibility to 9-((2-phosphonylmethoxy)ethyl)guanine			[64]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Probenecid inhibits the reaction SLC22A6 protein results in increased susceptibility to 9-(S)-(3-hydroxy-2-(phosphonomethoxy)propyl)adenine			[64]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	Probenecid inhibits the reaction SLC22A6 protein results in increased susceptibility to adefovir			[64]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	Probenecid inhibits the reaction SLC22A6 protein results in increased susceptibility to mercuric oxide co-treated with Acetylcysteine			[65]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	Probenecid inhibits the reaction SLC22A6 protein results in increased susceptibility to N(6)-cyclopropyl-9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine			[64]
Regulation Mechanism				Transcription Factor Info
DT Modulation10	Probenecid inhibits the reaction SLC22A6 protein results in increased susceptibility to Tenofovir			[64]
Regulation Mechanism				Transcription Factor Info
DT Modulation11	Probenecid inhibits the reaction SLC22A6 protein results in increased uptake of 6-carboxyfluorescein			[61]
Regulation Mechanism				Transcription Factor Info
DT Modulation12	Probenecid inhibits the reaction SLC22A6 protein results in increased uptake of 7-hydroxycoumarin metabolite			[61]
Regulation Mechanism				Transcription Factor Info
DT Modulation13	Probenecid inhibits the reaction SLC22A6 protein results in increased uptake of mercuric oxide co-treated with Acetylcysteine			[65]
Regulation Mechanism				Transcription Factor Info
DT Modulation14	Probenecid inhibits the reaction SLC22A6 protein results in increased uptake of p-Aminohippuric Acid			[78]
Regulation Mechanism				Transcription Factor Info
DT Modulation15	Probenecid inhibits the reaction SLC22A6 results in increased uptake of Aristolochic Acids which results in increased chemical synthesis of 7-(deoxyadenosin-N(6)-yl)aristolactam I			[63]
Regulation Mechanism				Transcription Factor Info
DT Modulation16	Probenecid inhibits the reaction SLC22A6 results in increased uptake of Aristolochic Acids which results in increased chemical synthesis of 7-(deoxyguanosin-N(2)-yl)aristolactam I			[63]
Regulation Mechanism				Transcription Factor Info
DT Modulation17	Probenecid results in decreased activity of SLC22A6 protein			[42]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Piroxicam results in decreased activity of SLC22A6 protein			[15]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Ketoprofen results in decreased activity of SLC22A6 protein			[15]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	SLC22A6 protein results in increased uptake of Ketoprofen			[15]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Indomethacin results in decreased activity of SLC22A6 protein			[15]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	SLC22A6 protein results in increased uptake of Indomethacin			[15]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Salicylic Acid results in decreased activity of SLC22A6 protein			[15]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	SLC22A6 protein results in increased uptake of Salicylic Acid			[15]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Cephaloridine inhibits the reaction SLC22A6 protein results in increased uptake of p-Aminohippuric Acid			[74]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	SLC22A6 protein results in increased uptake of Cephaloridine			[74]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Diclofenac results in decreased activity of SLC22A6 protein			[15]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Naproxen results in decreased activity of SLC22A6 protein			[15]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Phenacetin results in decreased activity of SLC22A6 protein			[15]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	SLC22A6 protein results in increased import of Cidofovir			[75]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	SLC22A6 protein results in increased susceptibility to Cidofovir			[64]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	SLC22A6 protein results in increased uptake of and results in increased susceptibility to Cidofovir			[67]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Mefenamic Acid results in decreased activity of SLC22A6 protein			[15]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Sulindac results in decreased activity of SLC22A6 protein			[15]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Luteolin results in decreased activity of SLC22A6 protein			[56]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Doxycycline inhibits the reaction SLC22A6 protein results in increased uptake of Anions			[33]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Minocycline inhibits the reaction SLC22A6 protein results in increased uptake of Anions			[33]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Oxytetracycline inhibits the reaction SLC22A6 protein results in increased uptake of Anions			[33]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Fluorescein inhibits the reaction SLC22A6 protein results in increased uptake of p-Aminohippuric Acid			[78]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Linoleic Acid results in decreased activity of SLC22A6 protein			[45]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Cefaclor inhibits the reaction SLC22A6 protein results in increased uptake of p-Aminohippuric Acid			[74]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	1-Methyl-4-phenylpyridinium inhibits the reaction SLC22A6 protein results in increased uptake of Cimetidine			[58]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Cimetidine inhibits the reaction SLC22A6 protein affects the transport of p-Aminohippuric Acid			[58]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	p-Aminohippuric Acid inhibits the reaction SLC22A6 protein results in increased uptake of Cimetidine			[58]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	SLC22A6 protein results in increased uptake of Cimetidine			[58]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine inhibits the reaction SLC22A6 protein results in increased import of 6-carboxyfluorescein			[42]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased activity of SLC22A6 protein			[42]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Emodin results in decreased activity of SLC22A6 protein			[45]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Benzo(a)pyrene affects the methylation of SLC22A6 promoter			[71]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Benzo(a)pyrene results in decreased activity of SLC22A6 protein			[55]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Benzo(a)pyrene results in increased methylation of SLC22A6 3' UTR			[71]
Regulation Mechanism				Transcription Factor Info
1-Methyl-4-phenylpyridinium	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	1-Methyl-4-phenylpyridinium inhibits the reaction SLC22A6 protein results in increased uptake of Cimetidine			[58]
Regulation Mechanism				Transcription Factor Info
2,4-Dichlorophenoxyacetic Acid	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	p-Aminohippuric Acid inhibits the reaction SLC22A6 protein results in increased uptake of 2,4-Dichlorophenoxyacetic Acid			[59]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	SLC22A6 protein results in increased uptake of 2,4-Dichlorophenoxyacetic Acid			[60]
Regulation Mechanism				Transcription Factor Info
4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid inhibits the reaction SLC22A6 protein affects the transport of Uric Acid			[13]
Regulation Mechanism				Transcription Factor Info
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction SLC22A6 protein results in increased uptake of p-Aminohippuric Acid			[57]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in decreased activity of SLC22A6 protein			[57]
Regulation Mechanism				Transcription Factor Info
6-carboxyfluorescein	9 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine inhibits the reaction SLC22A6 protein results in increased import of 6-carboxyfluorescein			[42]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	7-hydroxycoumarin inhibits the reaction SLC22A6 protein results in increased uptake of 6-carboxyfluorescein			[61]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	7-hydroxycoumarin metabolite inhibits the reaction SLC22A6 protein results in increased uptake of 6-carboxyfluorescein			[61]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	glutaric acid promotes the reaction SLC22A6 protein results in increased import of 6-carboxyfluorescein			[42]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Probenecid inhibits the reaction SLC22A6 protein results in increased import of 6-carboxyfluorescein			[42]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Probenecid inhibits the reaction SLC22A6 protein results in increased uptake of 6-carboxyfluorescein			[61]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	SLC22A6 protein results in increased import of 6-carboxyfluorescein			[42]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	SLC22A6 protein results in increased uptake of 6-carboxyfluorescein			[62]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	Unithiol analog inhibits the reaction SLC22A6 protein results in increased uptake of 6-carboxyfluorescein			[62]
Regulation Mechanism				Transcription Factor Info
7-(deoxyadenosin-N(6)-yl)aristolactam I	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Probenecid inhibits the reaction SLC22A6 results in increased uptake of Aristolochic Acids which results in increased chemical synthesis of 7-(deoxyadenosin-N(6)-yl)aristolactam I			[63]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	SLC22A6 results in increased uptake of Aristolochic Acids which results in increased chemical synthesis of 7-(deoxyadenosin-N(6)-yl)aristolactam I			[63]
Regulation Mechanism				Transcription Factor Info
7-(deoxyguanosin-N(2)-yl)aristolactam I	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Probenecid inhibits the reaction SLC22A6 results in increased uptake of Aristolochic Acids which results in increased chemical synthesis of 7-(deoxyguanosin-N(2)-yl)aristolactam I			[63]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	SLC22A6 results in increased uptake of Aristolochic Acids which results in increased chemical synthesis of 7-(deoxyguanosin-N(2)-yl)aristolactam I			[63]
Regulation Mechanism				Transcription Factor Info
7-hydroxycoumarin	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	7-hydroxycoumarin inhibits the reaction SLC22A6 protein results in increased uptake of 6-carboxyfluorescein			[61]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	7-hydroxycoumarin metabolite inhibits the reaction SLC22A6 protein results in increased uptake of 6-carboxyfluorescein			[61]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Probenecid inhibits the reaction SLC22A6 protein results in increased uptake of 7-hydroxycoumarin metabolite			[61]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	SLC22A6 protein results in increased uptake of 7-hydroxycoumarin metabolite			[61]
Regulation Mechanism				Transcription Factor Info
9-((2-phosphonylmethoxy)ethyl)guanine	5 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	9-((2-phosphonylmethoxy)ethyl)guanine analog inhibits the reaction SLC22A6 protein results in increased uptake of p-Aminohippuric Acid			[64]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Probenecid inhibits the reaction SLC22A6 protein results in increased susceptibility to 9-((2-phosphonylmethoxy)ethyl)guanine			[64]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Quercetin inhibits the reaction SLC22A6 protein results in increased susceptibility to 9-((2-phosphonylmethoxy)ethyl)guanine analog			[64]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	SLC22A6 protein results in increased susceptibility to 9-((2-phosphonylmethoxy)ethyl)guanine			[64]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	SLC22A6 protein results in increased susceptibility to 9-((2-phosphonylmethoxy)ethyl)guanine analog			[64]
Regulation Mechanism				Transcription Factor Info
Acetylcysteine	10 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	adipic acid inhibits the reaction SLC22A6 protein results in increased susceptibility to mercuric oxide co-treated with Acetylcysteine			[65]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Glutarates inhibits the reaction SLC22A6 protein results in increased uptake of mercuric oxide co-treated with Acetylcysteine			[65]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Ketoglutaric Acids inhibits the reaction SLC22A6 protein results in increased susceptibility to mercuric oxide co-treated with Acetylcysteine			[65]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	p-Aminohippuric Acid inhibits the reaction SLC22A6 protein results in increased susceptibility to mercuric oxide co-treated with Acetylcysteine			[65]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Probenecid inhibits the reaction SLC22A6 protein results in increased susceptibility to mercuric oxide co-treated with Acetylcysteine			[65]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Probenecid inhibits the reaction SLC22A6 protein results in increased uptake of mercuric oxide co-treated with Acetylcysteine			[65]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	SLC22A6 protein results in increased susceptibility to mercuric oxide co-treated with Acetylcysteine			[65]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	SLC22A6 protein results in increased transport of Acetylcysteine co-treated with Mercury			[66]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	SLC22A6 protein results in increased transport of Acetylcysteine co-treated with Methylmercury Compounds			[66]
Regulation Mechanism				Transcription Factor Info
DT Modulation10	SLC22A6 protein results in increased uptake of mercuric oxide co-treated with Acetylcysteine			[65]
Regulation Mechanism				Transcription Factor Info
adefovir	7 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	adefovir inhibits the reaction SLC22A6 protein results in increased uptake of p-Aminohippuric Acid			[64]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Probenecid inhibits the reaction SLC22A6 protein results in increased susceptibility to adefovir			[64]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	quercetin 3'-sulfate inhibits the reaction SLC22A6 protein affects the susceptibility to adefovir			[32]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	SLC22A6 protein affects the susceptibility to adefovir			[32]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	SLC22A6 protein results in increased susceptibility to adefovir			[64]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	SLC22A6 protein results in increased uptake of adefovir			[60]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	SLC22A6 protein results in increased uptake of and results in increased susceptibility to adefovir			[67]
Regulation Mechanism				Transcription Factor Info
adipic acid	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	adipic acid inhibits the reaction SLC22A6 protein results in increased susceptibility to mercuric oxide co-treated with Acetylcysteine			[65]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	adipic acid inhibits the reaction SLC22A6 protein results in increased transport of 2-amino-3-(2-amino-2-carboxyethylsulfanyl-mercuricsulfanyl)-propionic acid analog			[68]
Regulation Mechanism				Transcription Factor Info
Amitriptyline	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Amitriptyline inhibits the reaction SLC22A6 protein results in increased uptake of p-Aminohippuric Acid			[70]
Regulation Mechanism				Transcription Factor Info
aristolochic acid I	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	aristolochic acid I inhibits the reaction SLC22A6 results in increased uptake of p-Aminohippuric Acid			[63]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	aristolochic acid I promotes the reaction SLC22A6 results in increased export of p-Aminohippuric Acid			[63]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	wedelolactone results in decreased activity of SLC22A6 protein which results in increased susceptibility to and results in increased activity of aristolochic acid I			[56]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	wogonin results in decreased activity of SLC22A6 protein which results in increased susceptibility to and results in increased activity of aristolochic acid I			[56]
Regulation Mechanism				Transcription Factor Info
aurantio-obtusin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	aurantio-obtusin results in decreased activity of SLC22A6 protein			[45]
Regulation Mechanism				Transcription Factor Info
baicalein	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	baicalein results in decreased activity of SLC22A6 protein			[56]
Regulation Mechanism				Transcription Factor Info
Benzbromarone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Benzbromarone inhibits the reaction SLC22A6 protein affects the transport of Uric Acid			[13]
Regulation Mechanism				Transcription Factor Info
bisphenol A	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	bisphenol A promotes the reaction SLC22A6 protein results in increased uptake of p-Aminohippuric Acid			[72]
Regulation Mechanism				Transcription Factor Info
bisphenol F	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	bisphenol F promotes the reaction SLC22A6 protein results in increased uptake of p-Aminohippuric Acid			[72]
Regulation Mechanism				Transcription Factor Info
bisphenol S	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	bisphenol S inhibits the reaction SLC22A6 protein results in increased uptake of p-Aminohippuric Acid			[72]
Regulation Mechanism				Transcription Factor Info
Cadmium Chloride	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cadmium Chloride results in increased expression of SLC22A6 mRNA			[73]
Regulation Mechanism				Transcription Factor Info
Cefdinir	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cefdinir inhibits the reaction SLC22A6 protein results in increased uptake of p-Aminohippuric Acid			[74]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	SLC22A6 protein results in increased uptake of Cefdinir			[74]
Regulation Mechanism				Transcription Factor Info
cefoselis	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	cefoselis inhibits the reaction SLC22A6 protein results in increased uptake of p-Aminohippuric Acid			[74]
Regulation Mechanism				Transcription Factor Info
Cefotiam	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cefotiam inhibits the reaction SLC22A6 protein results in increased uptake of p-Aminohippuric Acid			[74]
Regulation Mechanism				Transcription Factor Info
Ceftibuten	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ceftibuten inhibits the reaction SLC22A6 protein results in increased uptake of p-Aminohippuric Acid			[74]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	SLC22A6 protein results in increased uptake of Ceftibuten			[74]
Regulation Mechanism				Transcription Factor Info
Ceftizoxime	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ceftizoxime inhibits the reaction SLC22A6 protein results in increased uptake of p-Aminohippuric Acid			[74]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	SLC22A6 protein results in increased uptake of Ceftizoxime			[74]
Regulation Mechanism				Transcription Factor Info
Chlorides	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Chlorides promotes the reaction SLC22A6 protein results in increased uptake of Glutarates			[53]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Chlorides promotes the reaction SLC22A6 protein results in increased uptake of ochratoxin A			[53]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Chlorides promotes the reaction SLC22A6 protein results in increased uptake of p-Aminohippuric Acid			[53]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Chlorides results in increased activity of SLC22A6 protein			[53]
Regulation Mechanism				Transcription Factor Info
chlorpyrifos-methyl	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	chlorpyrifos-methyl inhibits the reaction SLC22A6 protein results in increased uptake of p-Aminohippuric Acid			[70]
Regulation Mechanism				Transcription Factor Info
chrysophanic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	chrysophanic acid results in decreased activity of SLC22A6 protein			[45]
Regulation Mechanism				Transcription Factor Info
Cisplatin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cisplatin results in decreased expression of SLC22A6 protein			[76]
Regulation Mechanism				Transcription Factor Info
clothianidin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	clothianidin results in decreased activity of SLC22A6 protein			[54]
Regulation Mechanism				Transcription Factor Info
cyazofamid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	cyazofamid inhibits the reaction SLC22A6 protein results in increased uptake of p-Aminohippuric Acid			[77]
Regulation Mechanism				Transcription Factor Info
Diazepam	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Diazepam inhibits the reaction SLC22A6 protein results in increased uptake of p-Aminohippuric Acid			[70]
Regulation Mechanism				Transcription Factor Info
estrone sulfate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLC22A6 protein results in increased uptake of estrone sulfate			[74]
Regulation Mechanism				Transcription Factor Info
Fenitrothion	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Fenitrothion inhibits the reaction SLC22A6 protein results in increased uptake of p-Aminohippuric Acid			[70]
Regulation Mechanism				Transcription Factor Info
Genistein	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLC22A6 protein results in increased uptake of Genistein analog			[32]
Regulation Mechanism				Transcription Factor Info
gluconic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	gluconic acid inhibits the reaction SLC22A6 protein affects the transport of Uric Acid			[13]
Regulation Mechanism				Transcription Factor Info
glutaric acid	5 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	glutaric acid inhibits the reaction SLC22A6 protein results in increased transport of 2-amino-3-(2-amino-2-carboxyethylsulfanyl-mercuricsulfanyl)-propionic acid analog			[68]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	glutaric acid promotes the reaction SLC22A6 protein results in increased import of 6-carboxyfluorescein			[42]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	glutaric acid promotes the reaction SLC22A6 results in increased export of p-Aminohippuric Acid			[63]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	glutaric acid results in increased activity of SLC22A6 protein			[42]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	SLC22A6 protein results in increased import of glutaric acid			[42]
Regulation Mechanism				Transcription Factor Info
Glutathione	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLC22A6 protein results in increased susceptibility to mercuric oxide co-treated with Glutathione			[65]
Regulation Mechanism				Transcription Factor Info
Leucovorin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLC22A6 protein results in increased uptake of Leucovorin			[74]
Regulation Mechanism				Transcription Factor Info
mercuric oxide	9 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	adipic acid inhibits the reaction SLC22A6 protein results in increased susceptibility to mercuric oxide co-treated with Acetylcysteine			[65]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Glutarates inhibits the reaction SLC22A6 protein results in increased uptake of mercuric oxide co-treated with Acetylcysteine			[65]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Ketoglutaric Acids inhibits the reaction SLC22A6 protein results in increased susceptibility to mercuric oxide co-treated with Acetylcysteine			[65]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	p-Aminohippuric Acid inhibits the reaction SLC22A6 protein results in increased susceptibility to mercuric oxide co-treated with Acetylcysteine			[65]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Probenecid inhibits the reaction SLC22A6 protein results in increased susceptibility to mercuric oxide co-treated with Acetylcysteine			[65]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Probenecid inhibits the reaction SLC22A6 protein results in increased uptake of mercuric oxide co-treated with Acetylcysteine			[65]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	SLC22A6 protein results in increased susceptibility to mercuric oxide co-treated with Acetylcysteine			[65]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	SLC22A6 protein results in increased susceptibility to mercuric oxide co-treated with Glutathione			[65]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	SLC22A6 protein results in increased uptake of mercuric oxide co-treated with Acetylcysteine			[65]
Regulation Mechanism				Transcription Factor Info
Methotrexate	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Resveratrol inhibits the reaction SLC22A6 protein results in increased uptake of Methotrexate			[81]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	rhein metabolite inhibits the reaction SLC22A6 protein results in increased uptake of Methotrexate			[82]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	SLC22A6 protein results in increased susceptibility to Methotrexate			[81]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	SLC22A6 protein results in increased uptake of Methotrexate			[74]
Regulation Mechanism				Transcription Factor Info
methylmercury cysteine	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLC22A6 protein results in increased transport of methylmercury cysteine			[83]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	SLC22A6 results in increased transport of methylmercury cysteine			[84]
Regulation Mechanism				Transcription Factor Info
Mianserin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Mianserin inhibits the reaction SLC22A6 protein results in increased uptake of p-Aminohippuric Acid			[70]
Regulation Mechanism				Transcription Factor Info
obtusifolin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	obtusifolin results in decreased activity of SLC22A6 protein			[45]
Regulation Mechanism				Transcription Factor Info
p-Aminohippuric Acid	57 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction SLC22A6 protein results in increased uptake of p-Aminohippuric Acid			[57]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	9-((2-phosphonylmethoxy)ethyl)guanine analog inhibits the reaction SLC22A6 protein results in increased uptake of p-Aminohippuric Acid			[64]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	adefovir inhibits the reaction SLC22A6 protein results in increased uptake of p-Aminohippuric Acid			[64]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Amitriptyline inhibits the reaction SLC22A6 protein results in increased uptake of p-Aminohippuric Acid			[70]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	aristolochic acid I inhibits the reaction SLC22A6 results in increased uptake of p-Aminohippuric Acid			[63]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	aristolochic acid I promotes the reaction SLC22A6 results in increased export of p-Aminohippuric Acid			[63]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	bisphenol A promotes the reaction SLC22A6 protein results in increased uptake of p-Aminohippuric Acid			[72]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	bisphenol F promotes the reaction SLC22A6 protein results in increased uptake of p-Aminohippuric Acid			[72]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	bisphenol S inhibits the reaction SLC22A6 protein results in increased uptake of p-Aminohippuric Acid			[72]
Regulation Mechanism				Transcription Factor Info
DT Modulation10	Cefaclor inhibits the reaction SLC22A6 protein results in increased uptake of p-Aminohippuric Acid			[74]
Regulation Mechanism				Transcription Factor Info
DT Modulation11	Cefdinir inhibits the reaction SLC22A6 protein results in increased uptake of p-Aminohippuric Acid			[74]
Regulation Mechanism				Transcription Factor Info
DT Modulation12	cefoselis inhibits the reaction SLC22A6 protein results in increased uptake of p-Aminohippuric Acid			[74]
Regulation Mechanism				Transcription Factor Info
DT Modulation13	Cefotiam inhibits the reaction SLC22A6 protein results in increased uptake of p-Aminohippuric Acid			[74]
Regulation Mechanism				Transcription Factor Info
DT Modulation14	Ceftibuten inhibits the reaction SLC22A6 protein results in increased uptake of p-Aminohippuric Acid			[74]
Regulation Mechanism				Transcription Factor Info
DT Modulation15	Ceftizoxime inhibits the reaction SLC22A6 protein results in increased uptake of p-Aminohippuric Acid			[74]
Regulation Mechanism				Transcription Factor Info
DT Modulation16	Cephaloridine inhibits the reaction SLC22A6 protein results in increased uptake of p-Aminohippuric Acid			[74]
Regulation Mechanism				Transcription Factor Info
DT Modulation17	Chlorides promotes the reaction SLC22A6 protein results in increased uptake of p-Aminohippuric Acid			[53]
Regulation Mechanism				Transcription Factor Info
DT Modulation18	chlorpyrifos-methyl inhibits the reaction SLC22A6 protein results in increased uptake of p-Aminohippuric Acid			[70]
Regulation Mechanism				Transcription Factor Info
DT Modulation19	Cimetidine inhibits the reaction SLC22A6 protein affects the transport of p-Aminohippuric Acid			[58]
Regulation Mechanism				Transcription Factor Info
DT Modulation20	cyazofamid inhibits the reaction SLC22A6 protein results in increased uptake of p-Aminohippuric Acid			[77]
Regulation Mechanism				Transcription Factor Info
DT Modulation21	Diazepam inhibits the reaction SLC22A6 protein results in increased uptake of p-Aminohippuric Acid			[70]
Regulation Mechanism				Transcription Factor Info
DT Modulation22	Fenitrothion inhibits the reaction SLC22A6 protein results in increased uptake of p-Aminohippuric Acid			[70]
Regulation Mechanism				Transcription Factor Info
DT Modulation23	Fluorescein inhibits the reaction SLC22A6 protein results in increased uptake of p-Aminohippuric Acid			[78]
Regulation Mechanism				Transcription Factor Info
DT Modulation24	Glutarates promotes the reaction SLC22A6 protein results in increased uptake of p-Aminohippuric Acid			[13]
Regulation Mechanism				Transcription Factor Info
DT Modulation25	glutaric acid promotes the reaction SLC22A6 results in increased export of p-Aminohippuric Acid			[63]
Regulation Mechanism				Transcription Factor Info
DT Modulation26	Malathion inhibits the reaction SLC22A6 protein results in increased uptake of p-Aminohippuric Acid			[70]
Regulation Mechanism				Transcription Factor Info
DT Modulation27	Mianserin inhibits the reaction SLC22A6 protein results in increased uptake of p-Aminohippuric Acid			[70]
Regulation Mechanism				Transcription Factor Info
DT Modulation28	p-Aminohippuric Acid inhibits the reaction SLC22A6 protein results in increased susceptibility to mercuric oxide co-treated with Acetylcysteine			[65]
Regulation Mechanism				Transcription Factor Info
DT Modulation29	p-Aminohippuric Acid inhibits the reaction SLC22A6 protein results in increased transport of 2-amino-3-(2-amino-2-carboxyethylsulfanyl-mercuricsulfanyl)-propionic acid			[85]
Regulation Mechanism				Transcription Factor Info
DT Modulation30	p-Aminohippuric Acid inhibits the reaction SLC22A6 protein results in increased transport of 2-amino-3-(2-amino-2-carboxyethylsulfanyl-mercuricsulfanyl)-propionic acid analog			[68]
Regulation Mechanism				Transcription Factor Info
DT Modulation31	p-Aminohippuric Acid inhibits the reaction SLC22A6 protein results in increased uptake of 2,4-Dichlorophenoxyacetic Acid			[59]
Regulation Mechanism				Transcription Factor Info
DT Modulation32	p-Aminohippuric Acid inhibits the reaction SLC22A6 protein results in increased uptake of Cimetidine			[58]
Regulation Mechanism				Transcription Factor Info
DT Modulation33	p-Aminohippuric Acid inhibits the reaction SLC22A6 protein results in increased uptake of Uric Acid			[13]
Regulation Mechanism				Transcription Factor Info
DT Modulation34	Penicillin G inhibits the reaction SLC22A6 protein results in increased uptake of p-Aminohippuric Acid			[78]
Regulation Mechanism				Transcription Factor Info
DT Modulation35	Probenecid inhibits the reaction SLC22A6 protein results in increased import of p-Aminohippuric Acid			[42]
Regulation Mechanism				Transcription Factor Info
DT Modulation36	Probenecid inhibits the reaction SLC22A6 protein results in increased uptake of p-Aminohippuric Acid			[78]
Regulation Mechanism				Transcription Factor Info
DT Modulation37	quercetin 3'-sulfate inhibits the reaction SLC22A6 protein results in increased uptake of p-Aminohippuric Acid			[32]
Regulation Mechanism				Transcription Factor Info
DT Modulation38	Quercetin inhibits the reaction SLC22A6 protein results in increased uptake of p-Aminohippuric Acid			[86]
Regulation Mechanism				Transcription Factor Info
DT Modulation39	Resveratrol inhibits the reaction SLC22A6 protein results in increased uptake of p-Aminohippuric Acid			[81]
Regulation Mechanism				Transcription Factor Info
DT Modulation40	rhein inhibits the reaction SLC22A6 protein results in increased uptake of p-Aminohippuric Acid			[82]
Regulation Mechanism				Transcription Factor Info
DT Modulation41	rhein metabolite inhibits the reaction SLC22A6 protein results in increased uptake of p-Aminohippuric Acid			[82]
Regulation Mechanism				Transcription Factor Info
DT Modulation42	SLC22A6 protein affects the transport of p-Aminohippuric Acid			[58]
Regulation Mechanism				Transcription Factor Info
DT Modulation43	SLC22A6 protein results in increased import of p-Aminohippuric Acid			[42]
Regulation Mechanism				Transcription Factor Info
DT Modulation44	SLC22A6 protein results in increased secretion of p-Aminohippuric Acid			[78]
Regulation Mechanism				Transcription Factor Info
DT Modulation45	SLC22A6 protein results in increased uptake of p-Aminohippuric Acid			[78]
Regulation Mechanism				Transcription Factor Info
DT Modulation46	SLC22A6 results in increased export of p-Aminohippuric Acid			[63]
Regulation Mechanism				Transcription Factor Info
DT Modulation47	SLC22A6 results in increased uptake of p-Aminohippuric Acid			[63]
Regulation Mechanism				Transcription Factor Info
DT Modulation48	Succinic Acid results in increased activity of SLC22A6 protein which results in increased uptake of p-Aminohippuric Acid			[87]
Regulation Mechanism				Transcription Factor Info
DT Modulation49	Sulfobromophthalein inhibits the reaction SLC22A6 protein results in increased uptake of p-Aminohippuric Acid			[78]
Regulation Mechanism				Transcription Factor Info
DT Modulation50	Taurocholic Acid inhibits the reaction SLC22A6 protein results in increased uptake of p-Aminohippuric Acid			[78]
Regulation Mechanism				Transcription Factor Info
DT Modulation51	Tenofovir inhibits the reaction SLC22A6 protein results in increased uptake of p-Aminohippuric Acid			[64]
Regulation Mechanism				Transcription Factor Info
DT Modulation52	Tobacco Smoke Pollution inhibits the reaction SLC22A6 protein results in increased import of p-Aminohippuric Acid			[42]
Regulation Mechanism				Transcription Factor Info
DT Modulation53	Triazolam inhibits the reaction SLC22A6 protein results in increased uptake of p-Aminohippuric Acid			[70]
Regulation Mechanism				Transcription Factor Info
DT Modulation54	Unithiol inhibits the reaction SLC22A6 protein results in increased uptake of p-Aminohippuric Acid			[78]
Regulation Mechanism				Transcription Factor Info
DT Modulation55	Unithiol metabolite inhibits the reaction SLC22A6 protein results in increased uptake of p-Aminohippuric Acid			[78]
Regulation Mechanism				Transcription Factor Info
DT Modulation56	Unithiol metabolite promotes the reaction SLC22A6 protein results in increased secretion of p-Aminohippuric Acid			[78]
Regulation Mechanism				Transcription Factor Info
DT Modulation57	Unithiol promotes the reaction SLC22A6 protein results in increased secretion of p-Aminohippuric Acid			[78]
Regulation Mechanism				Transcription Factor Info
Penicillin G	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Penicillin G inhibits the reaction SLC22A6 protein results in increased uptake of p-Aminohippuric Acid			[78]
Regulation Mechanism				Transcription Factor Info
perfluoro-n-heptanoic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLC22A6 protein results in increased uptake of perfluoro-n-heptanoic acid			[88]
Regulation Mechanism				Transcription Factor Info
perfluorooctanoic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLC22A6 protein results in increased uptake of perfluorooctanoic acid			[88]
Regulation Mechanism				Transcription Factor Info
pyrazinoic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	pyrazinoic acid inhibits the reaction SLC22A6 protein affects the transport of Uric Acid			[13]
Regulation Mechanism				Transcription Factor Info
quercetin 3'-sulfate	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	quercetin 3'-sulfate inhibits the reaction SLC22A6 protein affects the susceptibility to adefovir			[32]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	quercetin 3'-sulfate inhibits the reaction SLC22A6 protein results in increased uptake of p-Aminohippuric Acid			[32]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	SLC22A6 protein results in increased uptake of quercetin 3'-sulfate			[32]
Regulation Mechanism				Transcription Factor Info
Ranitidine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLC22A6 protein results in increased uptake of Ranitidine			[90]
Regulation Mechanism				Transcription Factor Info
rhein	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	rhein inhibits the reaction SLC22A6 protein results in increased uptake of p-Aminohippuric Acid			[82]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	rhein metabolite inhibits the reaction SLC22A6 protein results in increased uptake of Methotrexate			[82]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	rhein metabolite inhibits the reaction SLC22A6 protein results in increased uptake of p-Aminohippuric Acid			[82]
Regulation Mechanism				Transcription Factor Info
Salicylates	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Salicylates inhibits the reaction SLC22A6 protein affects the transport of Uric Acid			[13]
Regulation Mechanism				Transcription Factor Info
sodium arsenite	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	sodium arsenite affects the methylation of SLC22A6 gene			[92]
Regulation Mechanism				Transcription Factor Info
Succinic Acid	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Succinic Acid results in increased activity of SLC22A6 protein			[87]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Succinic Acid results in increased activity of SLC22A6 protein which results in increased uptake of p-Aminohippuric Acid			[87]
Regulation Mechanism				Transcription Factor Info
Sulfobromophthalein	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sulfobromophthalein inhibits the reaction SLC22A6 protein results in increased uptake of p-Aminohippuric Acid			[78]
Regulation Mechanism				Transcription Factor Info
Taurocholic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Taurocholic Acid inhibits the reaction SLC22A6 protein results in increased uptake of p-Aminohippuric Acid			[78]
Regulation Mechanism				Transcription Factor Info
Tenofovir	5 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Probenecid inhibits the reaction SLC22A6 protein results in increased susceptibility to Tenofovir			[64]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	SLC22A6 protein results in increased import of Tenofovir			[75]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	SLC22A6 protein results in increased susceptibility to Tenofovir			[64]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	SLC22A6 protein results in increased uptake of and results in increased susceptibility to Tenofovir			[67]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Tenofovir inhibits the reaction SLC22A6 protein results in increased uptake of p-Aminohippuric Acid			[64]
Regulation Mechanism				Transcription Factor Info
Tetracycline	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLC22A6 protein results in increased export of Tetracycline			[33]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	SLC22A6 protein results in increased uptake of Tetracycline			[33]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Tetracycline inhibits the reaction SLC22A6 protein results in increased uptake of Anions			[33]
Regulation Mechanism				Transcription Factor Info
Thiram	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Thiram results in increased expression of SLC22A6 mRNA			[93]
Regulation Mechanism				Transcription Factor Info
traumatic acid	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Probenecid inhibits the reaction SLC22A6 protein affects the transport of traumatic acid			[89]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	SLC22A6 protein affects the transport of traumatic acid			[89]
Regulation Mechanism				Transcription Factor Info
Triazolam	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Triazolam inhibits the reaction SLC22A6 protein results in increased uptake of p-Aminohippuric Acid			[70]
Regulation Mechanism				Transcription Factor Info
Unithiol	5 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Unithiol analog inhibits the reaction SLC22A6 protein results in increased uptake of 6-carboxyfluorescein			[62]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Unithiol inhibits the reaction SLC22A6 protein results in increased uptake of p-Aminohippuric Acid			[78]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Unithiol metabolite inhibits the reaction SLC22A6 protein results in increased uptake of p-Aminohippuric Acid			[78]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Unithiol metabolite promotes the reaction SLC22A6 protein results in increased secretion of p-Aminohippuric Acid			[78]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Unithiol promotes the reaction SLC22A6 protein results in increased secretion of p-Aminohippuric Acid			[78]
Regulation Mechanism				Transcription Factor Info
Uric Acid	10 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid inhibits the reaction SLC22A6 protein affects the transport of Uric Acid			[13]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Benzbromarone inhibits the reaction SLC22A6 protein affects the transport of Uric Acid			[13]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	gluconic acid inhibits the reaction SLC22A6 protein affects the transport of Uric Acid			[13]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Glutarates promotes the reaction SLC22A6 protein results in increased uptake of Uric Acid			[13]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Ketoglutaric Acids inhibits the reaction SLC22A6 protein affects the transport of Uric Acid			[13]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	p-Aminohippuric Acid inhibits the reaction SLC22A6 protein results in increased uptake of Uric Acid			[13]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	Probenecid inhibits the reaction SLC22A6 protein affects the transport of Uric Acid			[13]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	pyrazinoic acid inhibits the reaction SLC22A6 protein affects the transport of Uric Acid			[13]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	Salicylates inhibits the reaction SLC22A6 protein affects the transport of Uric Acid			[13]
Regulation Mechanism				Transcription Factor Info
DT Modulation10	SLC22A6 protein results in increased uptake of Uric Acid			[13]
Regulation Mechanism				Transcription Factor Info
wedelolactone	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	wedelolactone results in decreased activity of SLC22A6 protein			[56]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	wedelolactone results in decreased activity of SLC22A6 protein which results in increased susceptibility to and results in increased activity of aristolochic acid I			[56]
Regulation Mechanism				Transcription Factor Info
wogonin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	wogonin results in decreased activity of SLC22A6 protein			[56]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	wogonin results in decreased activity of SLC22A6 protein which results in increased susceptibility to and results in increased activity of aristolochic acid I			[56]
Regulation Mechanism				Transcription Factor Info
Environmental toxicant
Mercury	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLC22A6 gene SNP affects the susceptibility to and affects the abundance of Mercury			[79]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	SLC22A6 gene SNP affects the susceptibility to Mercury			[80]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	SLC22A6 protein results in increased transport of Acetylcysteine co-treated with Mercury			[66]
Regulation Mechanism				Transcription Factor Info
Approved Drug
Probenecid	29 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Probenecid inhibits the transportation of 6-Carboxyfluorescein by SLC22A6 (IC50 = 6.3 microM)			[1]
Affected Drug/Substrate	6-Carboxyfluorescein	Modulation Type	Inhibition
Cell System	Chinese hamster ovary (CHO) cells-OAT1
DT Modulation2	Probenecid inhibits the transportation of Adefovir by SLC22A6 (IC50 = 7.4 microM)			[2]
Affected Drug/Substrate	Adefovir	Modulation Type	Inhibition
Cell System	Chinese hamster ovary (CHO) cells-OAT1
DT Modulation3	Probenecid inhibits the transportation of Aminohippuric acid by SLC22A6 (IC50 = 6.5 microM)			[3]
Affected Drug/Substrate	Aminohippuric acid	Modulation Type	Inhibition
Cell System	Chinese hamster ovary (CHO) cells-OAT1
DT Modulation4	Probenecid inhibits the transportation of Aminohippuric acid by SLC22A6 (Ki = 12.1 microM)			[4]
Affected Drug/Substrate	Aminohippuric acid	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT1
DT Modulation5	Probenecid inhibits the transportation of Aminohippuric acid by SLC22A6 (IC50 = 17 microM)			[5]
Affected Drug/Substrate	Aminohippuric acid	Modulation Type	Inhibition
Cell System	Oocytes-OAT1
DT Modulation6	Probenecid inhibits the transportation of Cidofovir by SLC22A6 (IC50 = 3.9 microM)			[6]
Affected Drug/Substrate	Cidofovir	Modulation Type	Inhibition
Cell System	Chinese hamster ovary (CHO) cells-OAT1
DT Modulation7	Probenecid inhibits the transportation of Dimesna by SLC22A6 (Ki = 26 microM)			[7]
Affected Drug/Substrate	Dimesna	Modulation Type	Inhibition
Cell System	Human cervical cancer cell line (Hela)-OAT1
DT Modulation8	Probenecid inhibits the transportation of Methotrexate by SLC22A6 (IC50 = 17 microM)			[5]
Affected Drug/Substrate	Methotrexate	Modulation Type	Inhibition
Cell System	Oocytes-OAT1
DT Modulation9	Probenecid inhibits the transportation of Ochratoxin A by SLC22A6 (Ki = 4.29 microM)			[8]
Affected Drug/Substrate	Ochratoxin A	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT1
DT Modulation10	Probenecid inhibits the transportation of Aminohippuric acid by SLC22A6			[9]
Affected Drug/Substrate	Aminohippuric acid	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OAT1
DT Modulation11	Probenecid inhibits the activity of SLC22A6			[10], [11]
DT Modulation12	Probenecid inhibits the activity of SLC22A6			[25]
Betamipron	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Betamipron inhibits the transportation of Adefovir by SLC22A6 (IC50 = 6 microM)			[2]
Affected Drug/Substrate	Adefovir	Modulation Type	Inhibition
Cell System	Chinese hamster ovary (CHO) cells-OAT1
DT Modulation2	Betamipron inhibits the transportation of Aminohippuric acid by SLC22A6 (IC50 = 16.2 microM)			[3]
Affected Drug/Substrate	Aminohippuric acid	Modulation Type	Inhibition
Cell System	Chinese hamster ovary (CHO) cells-OAT1
DT Modulation3	Betamipron inhibits the transportation of Aminohippuric acid by SLC22A6 (Ki = 23.6 microM)			[4]
Affected Drug/Substrate	Aminohippuric acid	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT1
DT Modulation4	Betamipron inhibits the activity of SLC22A6			[14]
Cell System	The Proximal Tubule (S2) Cells-OAT1
Piroxicam	5 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Piroxicam inhibits the transportation of Adefovir by SLC22A6 (IC50 = 20.5 microM)			[2]
Affected Drug/Substrate	Adefovir	Modulation Type	Inhibition
Cell System	Chinese hamster ovary (CHO) cells-OAT1
DT Modulation2	Piroxicam inhibits the transportation of Aminohippuric acid by SLC22A6 (IC50 = 62.8 microM)			[15]
Affected Drug/Substrate	Aminohippuric acid	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT1
DT Modulation3	Piroxicam inhibits the transportation of Ochratoxin A by SLC22A6 (Ki = 19.8 microM)			[8]
Affected Drug/Substrate	Ochratoxin A	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT1
DT Modulation4	Piroxicam inhibits the activity of SLC22A6			[8]
Ketoprofen	5 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ketoprofen inhibits the transportation of 6-Carboxyfluorescein by SLC22A6 (IC50 = 1.4 microM)			[1]
Affected Drug/Substrate	6-Carboxyfluorescein	Modulation Type	Inhibition
Cell System	Chinese hamster ovary (CHO) cells-OAT1
DT Modulation2	Ketoprofen inhibits the transportation of Adefovir by SLC22A6 (IC50 = 1.3 microM)			[2]
Affected Drug/Substrate	Adefovir	Modulation Type	Inhibition
Cell System	Chinese hamster ovary (CHO) cells-OAT1
DT Modulation3	Ketoprofen inhibits the transportation of Aminohippuric acid by SLC22A6 (IC50 = 4.34 microM)			[15]
Affected Drug/Substrate	Aminohippuric acid	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT1
Indomethacin	5 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Indomethacin inhibits the transportation of Adefovir by SLC22A6 (IC50 = 3 microM)			[2]
Affected Drug/Substrate	Adefovir	Modulation Type	Inhibition
Cell System	Chinese hamster ovary (CHO) cells-OAT1
DT Modulation2	Indomethacin inhibits the transportation of Aminohippuric acid by SLC22A6 (IC50 = 3.83 microM)			[15]
Affected Drug/Substrate	Aminohippuric acid	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT1
DT Modulation3	Indomethacin inhibits the activity of SLC22A6			[18]
Simvastatin	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Simvastatin inhibits the transportation of Aminohippuric acid by SLC22A6 (IC50 = 41.5 microM)			[16]
Affected Drug/Substrate	Aminohippuric acid	Modulation Type	Inhibition
Cell System	Oocytes-OAT1
DT Modulation2	Simvastatin inhibits the transportation of Aminohippuric acid by SLC22A6 (IC50 = 73.6 microM)			[17]
Affected Drug/Substrate	Aminohippuric acid	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT1
DT Modulation3	Simvastatin inhibits the activity of SLC22A6			[16]
Adefovir	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Adefovir inhibits the transportation of Ibuprofen by SLC22A6 (IC50 = 1.5 microM)			[2]
Affected Drug/Substrate	Ibuprofen	Modulation Type	Inhibition
Cell System	Chinese hamster ovary (CHO) cells-OAT1
DT Modulation2	Adefovir inhibits the transportation of Ketoprofen by SLC22A6 (IC50 = 0.9 microM)			[2]
Affected Drug/Substrate	Ketoprofen	Modulation Type	Inhibition
Cell System	Chinese hamster ovary (CHO) cells-OAT1
DT Modulation3	Adefovir inhibits the transportation of Naproxen by SLC22A6 (IC50 = 1.8 microM)			[2]
Affected Drug/Substrate	Naproxen	Modulation Type	Inhibition
Cell System	Chinese hamster ovary (CHO) cells-OAT1
Salicylic Acid	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Salicylic acid inhibits the transportation of 6-Carboxyfluorescein by SLC22A6 (IC50 = 280 microM)			[1]
Affected Drug/Substrate	6-Carboxyfluorescein	Modulation Type	Inhibition
Cell System	Chinese hamster ovary (CHO) cells-OAT1
DT Modulation2	Salicylic acid inhibits the transportation of Aminohippuric acid by SLC22A6 (IC50 = 325 microM)			[15]
Affected Drug/Substrate	Aminohippuric acid	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT1
Diclofenac	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Diclofenac inhibits the transportation of Adefovir by SLC22A6 (IC50 = 4 microM)			[2]
Affected Drug/Substrate	Adefovir	Modulation Type	Inhibition
Cell System	Chinese hamster ovary (CHO) cells-OAT1
DT Modulation2	Diclofenac inhibits the transportation of Aminohippuric acid by SLC22A6 (IC50 = 4.46 microM)			[15]
Affected Drug/Substrate	Aminohippuric acid	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT1
Ibuprofen	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ibuprofen inhibits the transportation of Adefovir by SLC22A6 (IC50 = 8 microM)			[2]
Affected Drug/Substrate	Adefovir	Modulation Type	Inhibition
Cell System	Chinese hamster ovary (CHO) cells-OAT1
DT Modulation2	Ibuprofen inhibits the transportation of Aminohippuric acid by SLC22A6 (IC50 = 55.6 microM)			[15]
Affected Drug/Substrate	Aminohippuric acid	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT1
DT Modulation3	Ibuprofen results in decreased activity of SLC22A6 protein			[15]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	SLC22A6 protein results in increased uptake of Ibuprofen			[15]
Regulation Mechanism				Transcription Factor Info
Naproxen	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Naproxen inhibits the transportation of Adefovir by SLC22A6 (IC50 = 5.8 microM)			[2]
Affected Drug/Substrate	Adefovir	Modulation Type	Inhibition
Cell System	Chinese hamster ovary (CHO) cells-OAT1
DT Modulation2	Naproxen inhibits the transportation of Aminohippuric acid by SLC22A6 (IC50 = 5.67 microM)			[15]
Affected Drug/Substrate	Aminohippuric acid	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT1
Chlorothiazide	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Chlorothiazide inhibits the transportation of Aminohippuric acid by SLC22A6 (IC50 = 3.78 microM)			[19]
Affected Drug/Substrate	Aminohippuric acid	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT1
DT Modulation2	Chlorothiazide inhibits the activity of SLC22A6			[23]
Cyclothiazide	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cyclothiazide inhibits the transportation of Aminohippuric acid by SLC22A6 (IC50 = 84.3 microM)			[19]
Affected Drug/Substrate	Aminohippuric acid	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT1
DT Modulation2	Cyclothiazide inhibits the activity of SLC22A6			[23]
Furosemide	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Furosemide inhibits the transportation of Aminohippuric acid by SLC22A6 (IC50 = 18 microM)			[19]
Affected Drug/Substrate	Aminohippuric acid	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT1
DT Modulation2	Furosemide inhibits the activity of SLC22A6			[18]
Hydrochlorothiazide	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Hydrochlorothiazide inhibits the transportation of Aminohippuric acid by SLC22A6 (IC50 = 67.3 microM)			[19]
Affected Drug/Substrate	Aminohippuric acid	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT1
DT Modulation2	Hydrochlorothiazide inhibits the activity of SLC22A6 (Ki = 150 microM)			[23]
Rifampicin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Rifampicin inhibits the transportation of Aminohippuric acid by SLC22A6 (IC50 = 79.1 microM)			[20]
Affected Drug/Substrate	Aminohippuric acid	Modulation Type	Inhibition
Cell System	Oocytes-OAT1
DT Modulation2	Rifampicin inhibits the transportation of Olmesartan medoxomil by SLC22A6 (Ki = 62.2 microM)			[20]
Affected Drug/Substrate	Olmesartan medoxomil	Modulation Type	Inhibition
Cell System	Oocytes-OAT1
Cephradine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cephradine inhibits the transportation of 6-Carboxyfluorescein by SLC22A6 (IC50 = 1600 microM)			[1]
Affected Drug/Substrate	6-Carboxyfluorescein	Modulation Type	Inhibition
Cell System	Chinese hamster ovary (CHO) cells-OAT1
Cidofovir	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cidofovir inhibits the transportation of 6-Carboxyfluorescein by SLC22A6 (IC50 = 60 microM)			[1]
Affected Drug/Substrate	6-Carboxyfluorescein	Modulation Type	Inhibition
Cell System	Chinese hamster ovary (CHO) cells-OAT1
Diflunisal	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Diflunisal inhibits the transportation of Adefovir by SLC22A6 (IC50 = 0.85 microM)			[2]
Affected Drug/Substrate	Adefovir	Modulation Type	Inhibition
Cell System	Chinese hamster ovary (CHO) cells-OAT1
Etodolac	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Etodolac inhibits the transportation of Adefovir by SLC22A6 (IC50 = 50 microM)			[2]
Affected Drug/Substrate	Adefovir	Modulation Type	Inhibition
Cell System	Chinese hamster ovary (CHO) cells-OAT1
Flurbiprofen	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Flurbiprofen inhibits the transportation of Adefovir by SLC22A6 (IC50 = 1.5 microM)			[2]
Affected Drug/Substrate	Adefovir	Modulation Type	Inhibition
Cell System	Chinese hamster ovary (CHO) cells-OAT1
Cilastatin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cilastatin inhibits the transportation of Aminohippuric acid by SLC22A6 (Ki = 1470 microM)			[4]
Affected Drug/Substrate	Aminohippuric acid	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT1
DT Modulation2	Cilastatin inhibits the uptake of diclofenac acyl glucuronide by SLC22A6			[36]
Affected Drug/Substrate	Diclofenac acyl glucuronide	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OAT1
Acetazolamide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Acetazolamide inhibits the transportation of Aminohippuric acid by SLC22A6 (IC50 = 75 microM)			[19]
Affected Drug/Substrate	Aminohippuric acid	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT1
Bumetanide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Bumetanide inhibits the transportation of Aminohippuric acid by SLC22A6 (IC50 = 7.6 microM)			[19]
Affected Drug/Substrate	Aminohippuric acid	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT1
Ethacrynic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ethacrynic acid inhibits the transportation of Aminohippuric acid by SLC22A6 (IC50 = 29.6 microM)			[19]
Affected Drug/Substrate	Aminohippuric acid	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT1
Methazolamide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Methazolamide inhibits the transportation of Aminohippuric acid by SLC22A6 (IC50 = 438 microM)			[19]
Affected Drug/Substrate	Aminohippuric acid	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT1
Trichlormethiazide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Trichloromethiazide inhibits the transportation of Aminohippuric acid by SLC22A6 (IC50 = 19.2 microM)			[19]
Affected Drug/Substrate	Aminohippuric acid	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT1
Novobiocin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Novobiocin inhibits the transportation of Aminohippuric acid by SLC22A6 (IC50 = 34.8 microM; Ki = 14.9 microM)			[26]
Affected Drug/Substrate	Aminohippuric acid	Modulation Type	Inhibition
Cell System	Monkey kidney tissue Fibroblast-like cell lines (COS)7-OAT1
Aspirin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Aspirin inhibits the transportation of Aminohippuric acid by SLC22A6 (IC50 = 769 microM)			[15]
Affected Drug/Substrate	Aminohippuric acid	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT1
DT Modulation2	Aspirin results in decreased activity of SLC22A6 protein			[15]
Regulation Mechanism				Transcription Factor Info
Mefenamic Acid	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Mefenamic acid inhibits the transportation of Aminohippuric acid by SLC22A6 (IC50 = 0.83 microM)			[15]
Affected Drug/Substrate	Aminohippuric acid	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT1
Sulindac	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sulindac inhibits the transportation of Aminohippuric acid by SLC22A6 (IC50 = 36.2 microM)			[15]
Affected Drug/Substrate	Aminohippuric acid	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT1
Fluvastatin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Fluvastatin inhibits the transportation of Aminohippuric acid by SLC22A6 (IC50 = 26.3 microM)			[17]
Affected Drug/Substrate	Aminohippuric acid	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT1
Pravastatin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Pravastatin inhibits the transportation of Aminohippuric acid by SLC22A6 (IC50 = 408 microM)			[17]
Affected Drug/Substrate	Aminohippuric acid	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT1
Ketoconazole	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ketoconazole inhibits the transportation of Aminohippuric acid by SLC22A6 (IC50 = 319 microM)			[20]
Affected Drug/Substrate	Aminohippuric acid	Modulation Type	Inhibition
Cell System	Oocytes-OAT1
Sulfasalazine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sulfasalazine inhibits the transportation of Methotrexate by SLC22A6 (IC50 = 4.6 microM)			[5]
Affected Drug/Substrate	Methotrexate	Modulation Type	Inhibition
Cell System	Oocytes-OAT1
Cefadroxil	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cefadroxil inhibits the transportation of Prostaglandin F2alpha by SLC22A6 (Ki = 6140 microM)			[22]
Affected Drug/Substrate	Prostaglandin F2alpha	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT1
Cefamandole	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cefamandole inhibits the transportation of Prostaglandin F2alpha by SLC22A6 (Ki = 30 microM)			[22]
Affected Drug/Substrate	Prostaglandin F2alpha	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT1
Cefazolin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cefazolin inhibits the transportation of Prostaglandin F2alpha by SLC22A6 (Ki = 180 microM)			[22]
Affected Drug/Substrate	Prostaglandin F2alpha	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT1
Cefoperazone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cefoperazone inhibits the transportation of Prostaglandin F2alpha by SLC22A6 (Ki = 210 microM)			[22]
Affected Drug/Substrate	Prostaglandin F2alpha	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT1
Cefotaxime	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cefotaxime inhibits the transportation of Prostaglandin F2alpha by SLC22A6 (Ki = 3130 microM)			[22]
Affected Drug/Substrate	Prostaglandin F2alpha	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT1
Ceftriaxone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ceftriaxone inhibits the transportation of Prostaglandin F2alpha by SLC22A6 (Ki = 230 microM)			[22]
Affected Drug/Substrate	Prostaglandin F2alpha	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT1
Cephalothin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cephalothin inhibits the transportation of Prostaglandin F2alpha by SLC22A6 (Ki = 220 microM)			[22]
Affected Drug/Substrate	Prostaglandin F2alpha	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT1
Candesartan	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Candesartan inhibits the transportation of Uric acid by SLC22A6 (IC50 = 17 microM)			[30]
Affected Drug/Substrate	Uric acid	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OAT1
Losartan	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Losartan inhibits the transportation of Uric acid by SLC22A6 (IC50 = 12 microM)			[30]
Affected Drug/Substrate	Uric acid	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OAT1
Olmesartan medoxomil	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Olmesartan medoxomil inhibits the transportation of Uric acid by SLC22A6 (IC50 = 0.28 microM)			[30]
Affected Drug/Substrate	Uric acid	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OAT1
Telmisartan	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Telmisartan inhibits the transportation of Uric acid by SLC22A6 (IC50 = 0.46 microM)			[30]
Affected Drug/Substrate	Uric acid	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OAT1
Valsartan	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Valsartan inhibits the transportation of Uric acid by SLC22A6 (IC50 = 16 microM)			[30]
Affected Drug/Substrate	Uric acid	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OAT1
Doxycycline	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Doxycycline inhibits the transportation of Aminohippuric acid by SLC22A6			[33]
Affected Drug/Substrate	Aminohippuric acid	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT1
Minocycline	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Minocycline inhibits the transportation of Aminohippuric acid by SLC22A6			[33]
Affected Drug/Substrate	Aminohippuric acid	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT1
Oxytetracycline	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Oxytetracycline inhibits the transportation of Aminohippuric acid by SLC22A6			[33]
Affected Drug/Substrate	Aminohippuric acid	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT1
Fluorescein	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Fluorescein inhibits the transportation of Aminohippuric acid by SLC22A6			[18]
Affected Drug/Substrate	Aminohippuric acid	Modulation Type	Inhibition
Cell System	Human cervical cancer cell line (Hela)-OAT1
Caspofungin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Caspofungin inhibits the transportation of Aminohippuric acid by SLC22A6			[34]
Affected Drug/Substrate	Aminohippuric acid	Modulation Type	Inhibition
Cell System	Human cervical cancer cell line (Hela)-OAT1
Linagliptin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Linagliptin inhibits the transportation of Aminohippuric acid by SLC22A6			[9]
Affected Drug/Substrate	Aminohippuric acid	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OAT1
Imipenem	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Imipenem significantly inhibits the uptake of cilastatin by SLC22A6			[35]
Affected Drug/Substrate	Cilastatin	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OAT1
Phenylbutazone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Phenylbutazone inhibits the transportation of Methotrexate by SLC22A6			[37]
Affected Drug/Substrate	Methotrexate	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT1
Cinoxacin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cinoxacin inhibits the transportation of P-aminohippuric acid by SLC22A6			[40]
Affected Drug/Substrate	P-aminohippuric acid	Modulation Type	Inhibition
Quercetin	5 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Quercetin inhibits the transportation of Para-aminohippuric acid by SLC22A6			[31]
Affected Drug/Substrate	Para-aminohippuric acid	Modulation Type	Inhibition
Bendroflumethiazide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Bendroflumethiazide inhibits the transportation of Polycyclic aromatic hydrocarbons by SLC22A6			[41]
Affected Drug/Substrate	Polycyclic aromatic hydrocarbons	Modulation Type	Inhibition
Piperacillin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Piperacillin inhibits the transporation of tazobactam by SLC22A6 (IC50 = 54.32 microM; Ki = 37 microM)			[43]
Affected Drug/Substrate	Tazobactam	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)
Acetaminophen	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Acetaminophen inhibits the expression of SLC22A6			[44]
DT Modulation2	Acetaminophen results in decreased activity of SLC22A6 protein			[15]
Regulation Mechanism				Transcription Factor Info
Cefaclor	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cefaclor inhibits the activity of SLC22A6			[46]
Amoxicillin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Amoxicillin inhibits the activity of SLC22A6			[47]
Cimetidine	5 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cimetidine inhibits the activity of SLC22A6			[11]
Lumiracoxib	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Lumiracoxib inhibits the activity of SLC22A6			[48]
Vancomycin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Vancomycin inhibits the activity of SLC22A6			[49]
Selexipag	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Selexipag inhibits the activity of SLC22A6			[50]
Eetuximab	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Eetuximab inhibits the activity of SLC22A6			[51]
Drug Marketed but not Approved by US FDA
Linoleic Acid	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Linoleic Acid inhibits the activity of SLC22A6			[45]
Drug in Phase 3 Trial
Benzylpenicillin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Benzylpenicillin inhibits the transportation of Aminohippuric acid by SLC22A6			[24]
Affected Drug/Substrate	Aminohippuric acid	Modulation Type	Inhibition
Cell System	Oocytes-OAT1
DT Modulation2	Benzylpenicillin inhibits the transportation of Ochratoxin A by SLC22A6			[8]
Affected Drug/Substrate	Ochratoxin A	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT1
Pratosartan	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Pratosartan inhibits the transportation of Uric acid by SLC22A6 (IC50 = 1.5 microM)			[30]
Affected Drug/Substrate	Uric acid	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OAT1
Drug in Phase 1/2 Trial
PRI-724	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	PRI-724 inhibits the activity of SLC22A6			[52]
Cell System	Human embryonic kidney 293 cells (HEK293)-
Drug in Phase 1 Trial
FT-0755769	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	FT-0755769 increases the activity of SLC22A6			[53]
Drug in Preclinical Test
Emodin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Emodin inhibits the activity of SLC22A6			[45]
Discontinued Drug
Cyclic cidofovir	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cyclic cidofovir inhibits the transportation of 6-Carboxyfluorescein by SLC22A6 (IC50 = 1100 microM)			[1]
Affected Drug/Substrate	6-Carboxyfluorescein	Modulation Type	Inhibition
Cell System	Chinese hamster ovary (CHO) cells-OAT1
Investigative Drug
Aminohippuric acid	5 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Aminohippuric acid inhibits the transportation of 6-Carboxyfluorescein by SLC22A6 (IC50 = 8.8 microM)			[1]
Affected Drug/Substrate	6-Carboxyfluorescein	Modulation Type	Inhibition
Cell System	Chinese hamster ovary (CHO) cells-OAT1
DT Modulation2	Aminohippuric acid inhibits the transportation of Bestatin by SLC22A6 (IC50 = 106 microM; Ki = 92 microM)			[12]
Affected Drug/Substrate	Bestatin	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OAT1
DT Modulation3	Aminohippuric acid inhibits the transportation of Ochratoxin A by SLC22A6 (Ki = 6.02 microM)			[8]
Affected Drug/Substrate	Ochratoxin A	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT1
DT Modulation4	Aminohippuric acid inhibits the transportation of Uric acid by SLC22A6 (IC50 = 127 microM)			[13]
Affected Drug/Substrate	Uric acid	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT1
DT Modulation5	Aminohippuric acid inhibits the activity of SLC22A6			[14]
Cell System	The Proximal Tubule (S2) Cells-OAT1
Glutarate	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Glutarate inhibits the transportation of 6-Carboxyfluorescein by SLC22A6 (IC50 = 4.9 microM)			[1]
Affected Drug/Substrate	6-Carboxyfluorescein	Modulation Type	Inhibition
Cell System	Chinese hamster ovary (CHO) cells-OAT1
DT Modulation2	Glutarate inhibits the transportation of Aminohippuric acid by SLC22A6 (IC50 = 3.3 microM)			[21]
Affected Drug/Substrate	Aminohippuric acid	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OAT1
Adipate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Adipate inhibits the transportation of Aminohippuric acid by SLC22A6 (IC50 = 6.2 microM)			[21]
Affected Drug/Substrate	Aminohippuric acid	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OAT1
Alpha-ketoglutaric acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Alpha-ketoglutaric acid inhibits the transportation of Aminohippuric acid by SLC22A6 (IC50 = 4.7 microM)			[21]
Affected Drug/Substrate	Aminohippuric acid	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OAT1
Fumarate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Fumarate inhibits the transportation of Aminohippuric acid by SLC22A6 (IC50 = 1733 microM)			[21]
Affected Drug/Substrate	Aminohippuric acid	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OAT1
Morin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Morin inhibits the transportation of Para-aminohippuric acid by SLC22A6 (IC50 = 0.3 microM)			[31]
Affected Drug/Substrate	Para-aminohippuric acid	Modulation Type	Inhibition
21H7	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	21H7 inhibits the activity of SLC22A6			[52]
Cell System	Human embryonic kidney 293 cells (HEK293)-
FH535	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	FH535 inhibits the activity of SLC22A6			[52]
Cell System	Human embryonic kidney 293 cells (HEK293)-
p-aminohippurate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	p-aminohippurate inhibits the uptake of imipenem by SLC22A6			[35]
Affected Drug/Substrate	Imipenem	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OAT1
JBP485	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	JBP485 inhibits the uptake of imipenem by SLC22A6			[94]
Affected Drug/Substrate	Imipenem	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-OAT1
Drug Withdrawn
Cephaloridine	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cephaloridine inhibits the transportation of 6-Carboxyfluorescein by SLC22A6 (IC50 = 1250 microM)			[1]
Affected Drug/Substrate	6-Carboxyfluorescein	Modulation Type	Inhibition
Cell System	Chinese hamster ovary (CHO) cells-OAT1
DT Modulation2	Cephaloridine inhibits the transportation of Prostaglandin F2alpha by SLC22A6 (Ki = 740 microM)			[22]
Affected Drug/Substrate	Prostaglandin F2alpha	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT1
Phenacetin	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Phenacetin inhibits the transportation of Adefovir by SLC22A6 (IC50 = 200 microM)			[2]
Affected Drug/Substrate	Adefovir	Modulation Type	Inhibition
Cell System	Chinese hamster ovary (CHO) cells-OAT1
DT Modulation2	Phenacetin inhibits the transportation of Aminohippuric acid by SLC22A6 (IC50 = 275 microM)			[15]
Affected Drug/Substrate	Aminohippuric acid	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT1
Natural Product
Citreoverdine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Citreoverdine inhibits the transportation of Organic anion by SLC22A6 (IC50 = 16.9 microM)			[27]
Affected Drug/Substrate	Organic anion	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT1
Cyclopiazonic acid	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cyclopiazonic acid inhibits the transportation of Organic anion by SLC22A6 (IC50 = 6.59 microM)			[27]
Affected Drug/Substrate	Organic anion	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT1
Fumonisin B1	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Fumonisin B1 inhibits the transportation of Organic anion by SLC22A6 (IC50 = 768 microM)			[27]
Affected Drug/Substrate	Organic anion	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT1
Patulin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Patulin inhibits the transportation of Organic anion by SLC22A6 (IC50 = 44.8 microM)			[27]
Affected Drug/Substrate	Organic anion	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT1
Gallic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Gallic acid inhibits the transportation of P-aminohippuric acid by SLC22A6 (IC50 = 1.2 microM)			[28]
Affected Drug/Substrate	P-aminohippuric acid	Modulation Type	Inhibition
Cell System	Chinese hamster ovary (CHO) cells-OAT1
Rosmarinic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Rosmarinic acid inhibits the transportation of P-aminohippuric acid by SLC22A6 (Ki = 0.35 microM)			[28]
Affected Drug/Substrate	P-aminohippuric acid	Modulation Type	Inhibition
Cell System	Chinese hamster ovary (CHO) cells-OAT1
Rhein	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Rhubarb inhibits the transportation of P-aminohippuric acid by SLC22A6 in a competitive manner (IC50 = 0.072 microM)			[29]
Affected Drug/Substrate	P-aminohippuric acid	Modulation Type	Inhibition
Cell System	Chinese hamster ovary (CHO) cells-OAT1
Luteolin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Luteolin inhibits the transportation of Para-aminohippuric acid by SLC22A6 (IC50 = 0.47 microM)			[31]
Affected Drug/Substrate	Para-aminohippuric acid	Modulation Type	Inhibition
Quercetin-3-O-sulfate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Quercetin-3-O-sulfate inhibits the transportation of Para-aminohippuric acid by SLC22A6 (IC50 = 1.22 microM)			[32]
Affected Drug/Substrate	Para-aminohippuric acid	Modulation Type	Inhibition
Ellagic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ellagic acid inhibits the transportation of Para-aminohippuric acid by SLC22A6			[38]
Affected Drug/Substrate	Para-aminohippuric acid	Modulation Type	Inhibition
Cell System	Xenopus laevis oocytes-OAT1
Silybin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Silybin inhibits the transportation of Para-aminohippuric acid by SLC22A6 in a competitive manner			[39]
Affected Drug/Substrate	Para-aminohippuric acid	Modulation Type	Inhibition
Cell System	Madin darby canine kidney strain cell line (MDCK)-OAT1
DT Modulation1	Quercetin inhibits the reaction SLC22A6 protein results in increased susceptibility to 9-((2-phosphonylmethoxy)ethyl)guanine analog			[64]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Quercetin inhibits the reaction SLC22A6 protein results in increased susceptibility to N(6)-cyclopropyl-9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine			[64]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Quercetin inhibits the reaction SLC22A6 protein results in increased uptake of p-Aminohippuric Acid			[86]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Quercetin results in decreased activity of SLC22A6 protein			[56]
Regulation Mechanism				Transcription Factor Info
Fisetin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Fisetin inhibits the transportation of Para-aminohippuric acid by SLC22A6 through competitive inhibition			[31]
Affected Drug/Substrate	Para-aminohippuric acid	Modulation Type	Inhibition
Genistein-4-O-sulfate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Genistein-4-O-sulfate inhibits the transportation of Para-aminohippuric acid by SLC22A6			[32]
Affected Drug/Substrate	Para-aminohippuric acid	Modulation Type	Inhibition
Cigarette smoke condensate (0.08mg/ml)	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cigarette smoke condensate (0.08mg/ml) inhibits the activity of SLC22A6			[42]
Cell System	Human embryonic kidney 293 cells (HEK293)-OAT1
Cigarette smoke condensate (0.32mg/ml)	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cigarette smoke condensate (0.32mg/ml) inhibits the activity of SLC22A6			[42]
Cell System	Human embryonic kidney 293 cells (HEK293)-OAT1
Tobacco Smoke Pollution	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tobacco Smoke Pollution inhibits the activity of SLC22A6			[42]
Chrysophanic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Chrysophanic acid inhibits the activity of SLC22A6			[45]
Baicalein	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Baicalein inhibits the activity of SLC22A6			[56]
Wogonin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Wogonin inhibits the activity of SLC22A6			[56]
Oroxylin A	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Oroxylin A inhibits the activity of SLC22A6 (IC50 = 0.961 microM)			[57]
Cell System	Human embryonic kidney 293 cells (HEK293)-SLC22A6
Resveratrol	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Plant Extracts co-treated with Resveratrol results in decreased expression of SLC22A6 mRNA			[91]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Resveratrol inhibits the reaction SLC22A6 protein results in increased uptake of Methotrexate			[81]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Resveratrol inhibits the reaction SLC22A6 protein results in increased uptake of p-Aminohippuric Acid			[81]
Regulation Mechanism				Transcription Factor Info
Dietary Constituent
Danshen	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Danshen inhibits the transportation of P-aminohippuric acid by SLC22A6 (Ki = 40.4 microM)			[28]
Affected Drug/Substrate	P-aminohippuric acid	Modulation Type	Inhibition
Cell System	Chinese hamster ovary (CHO) cells-OAT1
Mycotoxins
DT Modulation1	Cyclopiazonic acid inhibits the transportation of Organic anion by SLC22A6 (IC50 = 6.59 microM)			[27]
Affected Drug/Substrate	Organic anion	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT1
DT Modulation1	Fumonisin B1 inhibits the transportation of Organic anion by SLC22A6 (IC50 = 768 microM)			[27]
Affected Drug/Substrate	Organic anion	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT1
DT Modulation1	Patulin inhibits the transportation of Organic anion by SLC22A6 (IC50 = 44.8 microM)			[27]
Affected Drug/Substrate	Organic anion	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT1
Aflatoxin B1	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Aflatoxin B1 inhibits the transportation of Organic anion by SLC22A6 (IC50 = 12.3 microM)			[27]
Affected Drug/Substrate	Organic anion	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT1
DT Modulation2	Aflatoxin B1 results in decreased methylation of SLC22A6 5' UTR			[69]
Regulation Mechanism				Transcription Factor Info
Alpha-zearalenol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Alpha-zearalenol inhibits the transportation of Organic anion by SLC22A6 (IC50 = 28.4 microM)			[27]
Affected Drug/Substrate	Organic anion	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT1
Citrioveridine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Citrioveridine inhibits the transportation of Organic anion by SLC22A6 (IC50 = 16.9 microM)			[27]
Affected Drug/Substrate	Organic anion	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT1
Gliotoxin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Gliotoxin inhibits the transportation of Organic anion by SLC22A6 (IC50 = 117 microM)			[27]
Affected Drug/Substrate	Organic anion	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT1
Zearalenone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Zearalenone inhibits the transportation of Organic anion by SLC22A6 (IC50 = 147 microM)			[27]
Affected Drug/Substrate	Organic anion	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT1
ochratoxin A	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Chlorides promotes the reaction SLC22A6 protein results in increased uptake of ochratoxin A			[53]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	SLC22A6 protein results in increased uptake of ochratoxin A			[74]
Regulation Mechanism				Transcription Factor Info
Acute Toxic Substance
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine inhibits the activity of SLC22A6			[42]
Carcinogen
Benzo(a)pyrene	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Benzo(a)pyrene inhibits the activity of SLC22A6			[55]
Pesticide/Insecticide
Clothianidin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Clothianidin inhibits the activity of SLC22A6			[54]
Malathion	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Malathion inhibits the reaction SLC22A6 protein results in increased uptake of p-Aminohippuric Acid			[70]
Regulation Mechanism				Transcription Factor Info

References
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52	Impaired Transport Activity of Human Organic Anion Transporters (OATs) and Organic Anion Transporting Polypeptides (OATPs) by Wnt Inhibitors. J Pharm Sci. 2021 Feb;110(2):914-924.
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54	Neonicotinoid pesticides poorly interact with human drug transporters. J Biochem Mol Toxicol. 2019 Oct;33(10):e22379.
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56	Potent Inhibitors of Organic Anion Transporters 1 and 3 From Natural Compounds and Their Protective Effect on Aristolochic Acid Nephropathy. Toxicol Sci. 2020 Jun 1;175(2):279-291.
57	Interactions between Oroxylin A with the solute carrier transporters and ATP-binding cassette transporters: Drug transporters profile for this flavonoid. Chem Biol Interact. 2020 Jun 1;324:109097.
58	Different transport properties between famotidine and cimetidine by human renal organic ion transporters (SLC22A). Eur J Pharmacol. 2004 Oct 25;503(1-3):25-30.
59	Characterization of the uptake of organic anion transporter (OAT) 1 and OAT3 substrates by human kidney slices. J Pharmacol Exp Ther. 2007;321(1):362-9.
60	The flounder organic anion transporter fOat has sequence, function, and substrate specificity similarity to both mammalian Oat1 and Oat3. Am J Physiol Regul Integr Comp Physiol. 2006;291(6):R1773-80.
61	7-Hydroxycoumarin and its conjugated metabolites interact with organic anion transporters 1 and 3 in vitro and in vivo. Chem Biol Interact. 2025;405:111293.
62	Organic anion transporter 3 (OAT3) and renal transport of the metal chelator 2,3-dimercapto-1-propanesulfonic acid (DMPS). Can J Physiol Pharmacol. 2010;88(2):141-6.
63	Molecular evidence for an involvement of organic anion transporters (OATs) in aristolochic acid nephropathy. Toxicology. 2009;264(1-2):74-9.
64	Interactions with selected drug renal transporters and transporter-mediated cytotoxicity in antiviral agents from the group of acyclic nucleoside phosphonates. Toxicology. 2013;311(3):135-46.
65	Human renal organic anion transporter 1-dependent uptake and toxicity of mercuric-thiol conjugates in Madin-Darby canine kidney cells. Mol Pharmacol. 2003;63(3):590-6.
66	Transport of N-acetylcysteine s-conjugates of methylmercury in Madin-Darby canine kidney cells stably transfected with human isoform of organic anion transporter 1. J Pharmacol Exp Ther. 2005;314(3):1158-68.
67	Intracellular concentrations determine the cytotoxicity of adefovir, cidofovir and tenofovir. Toxicol In Vitro. 2015;29(1):251-8.
68	Homocysteine and the renal epithelial transport and toxicity of inorganic mercury: role of basolateral transporter organic anion transporter 1. J Am Soc Nephrol. 2004;15(8):2023-31.
69	Effect of aflatoxin B(1), benzo[a]pyrene, and methapyrilene on transcriptomic and epigenetic alterations in human liver HepaRG cells. Food Chem Toxicol. 2018;121:214-223.
70	Interactions of human organic anion transporter 1 (hOAT1) with substances associated with forensic toxicology. Leg Med (Tokyo). 2011 Jul;13(4):180-5.
71	Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017;8(1):1369-1391.
72	Inhibition of SLC drug transporter activities by environmental bisphenols. Toxicol In Vitro. 2017 Apr;40:34-44.
73	Evaluation of cadmium-induced transcriptome alterations by three color cDNA labeling microarray analysis on a T-cell line. Toxicology. 2002;178(2):135-60.
74	Human organic anion transporter hOAT3 is a potent transporter of cephalosporin antibiotics, in comparison with hOAT1. Biochem Pharmacol. 2005 Oct 1;70(7):1104-13.
75	Transporter-dependent cytotoxicity of antiviral drugs in primary cultures of human proximal tubular cells. Toxicology. 2018;404-405:10-24.
76	The toxicity of cisplatin derives from effects on renal organic ion transporters expression and serum endogenous substance levels. Food Chem Toxicol. 2024;192:114949.
77	Interactions between cyazofamid and human drug transporters. J Biochem Mol Toxicol. 2020;34(4):e22459.
78	Interaction of 2,3-dimercapto-1-propane sulfonate with the human organic anion transporter hOAT1. J Pharmacol Exp Ther. 2001 Nov;299(2):741-7.
79	Polymorphisms in genes encoding potential mercury transporters and urine mercury concentrations in populations exposed to mercury vapor from gold mining. Environ Health Perspect. 2013;121(1):85-91.
80	Genetic Polymorphisms in Multispecific Transporters Mitigate Mercury Nephrotoxicity in an Artisanal and Small-Scale Gold Mining Community in Colombia. Toxicol Sci. 2020;178(2):338-346.
81	P-gp, MRP2 and OAT1/OAT3 mediate the drug-drug interaction between resveratrol and methotrexate. Toxicol Appl Pharmacol. 2016;306:27-35.
82	Interaction between rhein acyl glucuronide and methotrexate based on human organic anion transporters. Chem Biol Interact. 2017;277:79-84.
83	Handling of the homocysteine S-conjugate of methylmercury by renal epithelial cells: role of organic anion transporter 1 and amino acid transporters. J Pharmacol Exp Ther. 2005;315(2):896-904.
84	Handling of cysteine S-conjugates of methylmercury in MDCK cells expressing human OAT1. Kidney Int. 2005;68(4):1684-99.
85	Human organic anion transporter 1 mediates cellular uptake of cysteine-S conjugates of inorganic mercury. Kidney Int. 2004;66(1):251-61.
86	Allopurinol, rutin, and quercetin attenuate hyperuricemia and renal dysfunction in rats induced by fructose intake: renal organic ion transporter involvement. Am J Physiol Renal Physiol. 2009;297(4):F1080-91.
87	Lack of efflux of diglycolic acid from proximal tubule cells leads to its accumulation and to toxicity of diethylene glycol. Toxicol Lett. 2023;379:48-55.
88	In vitro and in silico characterization of the transport of selected perfluoroalkyl carboxylic acids and perfluoroalkyl sulfonic acids by human organic anion transporter 1 (OAT1), OAT2 and OAT3. Toxicology. 2024;509:153961.
89	Identification of a substrate of the renal tubular transporters for detecting drug-induced early acute kidney injury. Toxicol Sci. 2024;201(2):190-205.
90	A species difference in the transport activities of H2 receptor antagonists by rat and human renal organic anion and cation transporters. J Pharmacol Exp Ther. 2005 Oct;315(1):337-45.
91	One-year supplementation with a grape extract containing resveratrol modulates inflammatory-related microRNAs and cytokines expression in peripheral blood mononuclear cells of type 2 diabetes and hypertensive patients with coronary artery disease. Pharmacol Res. 2013;72:69-82.
92	Microarray dataset of transient and permanent DNA methylation changes in HeLa cells undergoing inorganic arsenic-mediated epithelial-to-mesenchymal transition. Data Brief. 2017;13:6-9.
93	High-Throughput Transcriptomics of Nontumorigenic Breast Cells Exposed to Environmentally Relevant Chemicals. Environ Health Perspect. 2024;132(4):47002.
94	JBP485, A Dual Inhibitor of Organic Anion Transporters (OATs) and Renal Dehydropeptidase-I (DHP-I), Protects Against Imipenem-Induced Nephrotoxicity. Front Pharmacol. 2022 Jun 8;13:938813.

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