Detail Information of Exogenous Modulation

General Information of Drug Transporter (DT)
DT ID	DTD0007 Transporter Info
Gene Name	SLC47A1
Transporter Name	Multidrug and toxin extrusion protein 1
Gene ID	55244
UniProt ID	Q96FL8

Exogenous factors (drugs, dietary constituents, etc.) Modulation of This DT (EGM)
Chemical Compound
DT Modulation1	Ranitidine inhibits the reaction SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[4]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Quinine inhibits the reaction SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[4]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Cimetidine inhibits the reaction SLC47A1 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[50]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Cimetidine inhibits the reaction SLC47A1 protein results in increased uptake of Cadmium			[59]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Cimetidine results in decreased activity of SLC47A1 protein			[18]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	SLC47A1 protein affects the transport of Cimetidine			[18]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Amantadine inhibits the reaction SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[4]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Famotidine inhibits the reaction SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[4]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Imipramine inhibits the reaction SLC47A1 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[50]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Imipramine results in decreased activity of SLC47A1 protein			[18]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Procainamide analog inhibits the reaction SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[4]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Procainamide inhibits the reaction SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[4]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Verapamil inhibits the reaction SLC47A1 protein results in increased import of Tetraethylammonium			[8]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Verapamil inhibits the reaction SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[4]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Verapamil inhibits the reaction SLC47A1 protein results in increased uptake of Tetraethylammonium			[39]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Verapamil results in decreased activity of SLC47A1 protein			[75]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Clonidine inhibits the reaction SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[4]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Amiloride inhibits the reaction SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[4]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Amiloride results in decreased activity of SLC47A1 protein			[18]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Quinidine inhibits the reaction SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[4]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Quinidine results in decreased activity of SLC47A1 protein			[18]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Cisplatin co-treated with jinfukang results in increased expression of SLC47A1 mRNA			[25]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Pyrimethamine analog inhibits the reaction SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[4]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Pyrimethamine inhibits the reaction SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[4]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Pyrimethamine inhibits the reaction SLC47A1 protein results in increased uptake of Metformin			[4]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Pyrimethamine inhibits the reaction SLC47A1 protein results in increased uptake of Tetraethylammonium			[30]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Pyrimethamine results in decreased activity of SLC47A1 protein			[30]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Estradiol co-treated with Progesterone results in decreased expression of SLC47A1 mRNA			[61]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Estradiol co-treated with TGFB1 protein results in decreased expression of SLC47A1 mRNA			[62]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Progesterone co-treated with Estradiol results in increased expression of SLC47A1 mRNA			[63]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC47A1 mRNA			[51]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Valproic Acid affects the expression of SLC47A1 mRNA			[74]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Trimethoprim inhibits the reaction SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[4]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Ketoconazole inhibits the reaction SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[4]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Benzo(a)pyrene affects the methylation of SLC47A1 promoter			[57]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Benzo(a)pyrene results in increased methylation of SLC47A1 exon			[57]
Regulation Mechanism				Transcription Factor Info
1-Methyl-4-phenylpyridinium	57 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	1-Methyl-4-phenylpyridinium inhibits the reaction SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[4]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	1-Methyl-4-phenylpyridinium results in decreased activity of SLC47A1 protein			[18]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Agmatine inhibits the reaction SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[4]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Amantadine inhibits the reaction SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[4]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Amiloride inhibits the reaction SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[4]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Atropine inhibits the reaction SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[4]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	Caffeine affects the reaction SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[4]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	Chloramphenicol affects the reaction SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[4]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	cinchonidine inhibits the reaction SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[4]
Regulation Mechanism				Transcription Factor Info
DT Modulation10	cinchonine inhibits the reaction SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[4]
Regulation Mechanism				Transcription Factor Info
DT Modulation11	Clonidine inhibits the reaction SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[4]
Regulation Mechanism				Transcription Factor Info
DT Modulation12	Creatinine inhibits the reaction SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[4]
Regulation Mechanism				Transcription Factor Info
DT Modulation13	ethohexadiol affects the reaction SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[4]
Regulation Mechanism				Transcription Factor Info
DT Modulation14	Famotidine inhibits the reaction SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[4]
Regulation Mechanism				Transcription Factor Info
DT Modulation15	Guanfacine inhibits the reaction SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[4]
Regulation Mechanism				Transcription Factor Info
DT Modulation16	Guanidine affects the reaction SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[4]
Regulation Mechanism				Transcription Factor Info
DT Modulation17	Histamine inhibits the reaction SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[4]
Regulation Mechanism				Transcription Factor Info
DT Modulation18	Imiquimod inhibits the reaction SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[4]
Regulation Mechanism				Transcription Factor Info
DT Modulation19	Ketoconazole inhibits the reaction SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[4]
Regulation Mechanism				Transcription Factor Info
DT Modulation20	Metformin inhibits the reaction SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[4]
Regulation Mechanism				Transcription Factor Info
DT Modulation21	Midodrine inhibits the reaction SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[4]
Regulation Mechanism				Transcription Factor Info
DT Modulation22	Naloxone inhibits the reaction SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[4]
Regulation Mechanism				Transcription Factor Info
DT Modulation23	Nialamide inhibits the reaction SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[4]
Regulation Mechanism				Transcription Factor Info
DT Modulation24	Nicotinamide Mononucleotide inhibits the reaction SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[4]
Regulation Mechanism				Transcription Factor Info
DT Modulation25	Nicotine inhibits the reaction SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[4]
Regulation Mechanism				Transcription Factor Info
DT Modulation26	Paraquat inhibits the reaction SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[4]
Regulation Mechanism				Transcription Factor Info
DT Modulation27	Phenformin inhibits the reaction SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[4]
Regulation Mechanism				Transcription Factor Info
DT Modulation28	Phentolamine inhibits the reaction SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[4]
Regulation Mechanism				Transcription Factor Info
DT Modulation29	Procainamide analog inhibits the reaction SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[4]
Regulation Mechanism				Transcription Factor Info
DT Modulation30	Procainamide inhibits the reaction SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[4]
Regulation Mechanism				Transcription Factor Info
DT Modulation31	Proguanil inhibits the reaction SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[4]
Regulation Mechanism				Transcription Factor Info
DT Modulation32	Propranolol inhibits the reaction SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[4]
Regulation Mechanism				Transcription Factor Info
DT Modulation33	Protons inhibits the reaction SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[4]
Regulation Mechanism				Transcription Factor Info
DT Modulation34	Pyrimethamine analog inhibits the reaction SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[4]
Regulation Mechanism				Transcription Factor Info
DT Modulation35	Pyrimethamine inhibits the reaction SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[4]
Regulation Mechanism				Transcription Factor Info
DT Modulation36	Quinidine inhibits the reaction SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[4]
Regulation Mechanism				Transcription Factor Info
DT Modulation37	Quinine inhibits the reaction SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[4]
Regulation Mechanism				Transcription Factor Info
DT Modulation38	Ranitidine inhibits the reaction SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[4]
Regulation Mechanism				Transcription Factor Info
DT Modulation39	Scopolamine inhibits the reaction SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[4]
Regulation Mechanism				Transcription Factor Info
DT Modulation40	Serotonin inhibits the reaction SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[4]
Regulation Mechanism				Transcription Factor Info
DT Modulation41	SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[4]
Regulation Mechanism				Transcription Factor Info
DT Modulation42	Sulfadimethoxine affects the reaction SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[4]
Regulation Mechanism				Transcription Factor Info
DT Modulation43	Sulfamerazine affects the reaction SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[4]
Regulation Mechanism				Transcription Factor Info
DT Modulation44	Tacrine inhibits the reaction SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[4]
Regulation Mechanism				Transcription Factor Info
DT Modulation45	tetrabutylammonium inhibits the reaction SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[4]
Regulation Mechanism				Transcription Factor Info
DT Modulation46	Tetraethylammonium inhibits the reaction SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[4]
Regulation Mechanism				Transcription Factor Info
DT Modulation47	tetramethylammonium affects the reaction SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[4]
Regulation Mechanism				Transcription Factor Info
DT Modulation48	tetrapentylammonium inhibits the reaction SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[4]
Regulation Mechanism				Transcription Factor Info
DT Modulation49	tetrapropylammonium inhibits the reaction SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[4]
Regulation Mechanism				Transcription Factor Info
DT Modulation50	Ticlopidine affects the reaction SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[4]
Regulation Mechanism				Transcription Factor Info
DT Modulation51	Topiramate affects the reaction SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[4]
Regulation Mechanism				Transcription Factor Info
DT Modulation52	Tramadol inhibits the reaction SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[4]
Regulation Mechanism				Transcription Factor Info
DT Modulation53	Trichlormethiazide inhibits the reaction SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[4]
Regulation Mechanism				Transcription Factor Info
DT Modulation54	triethylmethylammonium inhibits the reaction SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[4]
Regulation Mechanism				Transcription Factor Info
DT Modulation55	Trimethoprim inhibits the reaction SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[4]
Regulation Mechanism				Transcription Factor Info
DT Modulation56	Tyramine inhibits the reaction SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[4]
Regulation Mechanism				Transcription Factor Info
DT Modulation57	Verapamil inhibits the reaction SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[4]
Regulation Mechanism				Transcription Factor Info
3-amino-1,4-dimethyl-5H-pyrido(4,3-b)indole	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	3-amino-1,4-dimethyl-5H-pyrido(4,3-b)indole results in decreased activity of SLC47A1 protein			[49]
Regulation Mechanism				Transcription Factor Info
3-amino-1-methyl-5H-pyrido(4,3-b)indole	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	3-amino-1-methyl-5H-pyrido(4,3-b)indole results in decreased activity of SLC47A1 protein			[49]
Regulation Mechanism				Transcription Factor Info
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid results in increased expression of SLC47A1 mRNA			[37]
Regulation Mechanism				Transcription Factor Info
4-(4-dimethylaminostyryl)-1-methylpyridinium	7 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cimetidine inhibits the reaction SLC47A1 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[50]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Dipyridamole inhibits the reaction SLC47A1 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[50]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Imipramine inhibits the reaction SLC47A1 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[50]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Ondansetron inhibits the reaction SLC47A1 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[50]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	SLC47A1 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[50]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Tacrine inhibits the reaction SLC47A1 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[50]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	zafirlukast inhibits the reaction SLC47A1 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[50]
Regulation Mechanism				Transcription Factor Info
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC47A1 mRNA			[51]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC47A1 mRNA			[51]
Regulation Mechanism				Transcription Factor Info
4-chloro-N-((4-(1,1-dimethylethyl)phenyl)methyl)-3-ethyl-1-methyl-1H-pyrazole-5-carboxamide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	4-chloro-N-((4-(1,1-dimethylethyl)phenyl)methyl)-3-ethyl-1-methyl-1H-pyrazole-5-carboxamide results in increased expression of SLC47A1 mRNA			[52]
Regulation Mechanism				Transcription Factor Info
abrine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	abrine results in decreased expression of SLC47A1 mRNA			[53]
Regulation Mechanism				Transcription Factor Info
Agmatine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Agmatine inhibits the reaction SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[4]
Regulation Mechanism				Transcription Factor Info
Atropine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Atropine inhibits the reaction SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[4]
Regulation Mechanism				Transcription Factor Info
bardoxolone methyl	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	bardoxolone methyl results in increased expression of SLC47A1 mRNA			[56]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	bardoxolone methyl results in increased expression of SLC47A1 protein			[56]
Regulation Mechanism				Transcription Factor Info
bisphenol A	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	bisphenol A co-treated with Fulvestrant results in increased methylation of SLC47A1 gene			[58]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	bisphenol A inhibits the reaction SLC47A1 protein results in increased uptake of Tetraethylammonium			[39]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	bisphenol A results in decreased activity of SLC47A1 protein			[39]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	bisphenol A results in decreased methylation of SLC47A1 gene			[58]
Regulation Mechanism				Transcription Factor Info
bisphenol F	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	bisphenol F inhibits the reaction SLC47A1 protein results in increased uptake of Tetraethylammonium			[39]
Regulation Mechanism				Transcription Factor Info
bisphenol S	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	bisphenol S inhibits the reaction SLC47A1 protein results in increased uptake of Tetraethylammonium			[39]
Regulation Mechanism				Transcription Factor Info
Cadmium Chloride	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cadmium Chloride results in decreased expression of SLC47A1 mRNA			[60]
Regulation Mechanism				Transcription Factor Info
Chloramphenicol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Chloramphenicol affects the reaction SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[4]
Regulation Mechanism				Transcription Factor Info
cinchonidine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	cinchonidine inhibits the reaction SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[4]
Regulation Mechanism				Transcription Factor Info
cinchonine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	cinchonine inhibits the reaction SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[4]
Regulation Mechanism				Transcription Factor Info
Creatinine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Creatinine inhibits the reaction SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[4]
Regulation Mechanism				Transcription Factor Info
Dipyridamole	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Dipyridamole inhibits the reaction SLC47A1 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[50]
Regulation Mechanism				Transcription Factor Info
dorsomorphin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC47A1 mRNA			[51]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC47A1 mRNA			[51]
Regulation Mechanism				Transcription Factor Info
entinostat	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	entinostat results in increased expression of SLC47A1 mRNA			[38]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of SLC47A1 mRNA			[51]
Regulation Mechanism				Transcription Factor Info
ethohexadiol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ethohexadiol affects the reaction SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[4]
Regulation Mechanism				Transcription Factor Info
Fluorouracil	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLC47A1 protein affects the susceptibility to Fluorouracil			[64]
Regulation Mechanism				Transcription Factor Info
Fulvestrant	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	bisphenol A co-treated with Fulvestrant results in increased methylation of SLC47A1 gene			[58]
Regulation Mechanism				Transcription Factor Info
Guanfacine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Guanfacine inhibits the reaction SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[4]
Regulation Mechanism				Transcription Factor Info
Guanidine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Guanidine affects the reaction SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[4]
Regulation Mechanism				Transcription Factor Info
Histamine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Histamine inhibits the reaction SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[4]
Regulation Mechanism				Transcription Factor Info
ICG 001	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ICG 001 results in increased expression of SLC47A1 mRNA			[37]
Regulation Mechanism				Transcription Factor Info
Imiquimod	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Imiquimod inhibits the reaction SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[4]
Regulation Mechanism				Transcription Factor Info
methyleugenol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	methyleugenol results in decreased expression of SLC47A1 mRNA			[44]
Regulation Mechanism				Transcription Factor Info
Midodrine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Midodrine inhibits the reaction SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[4]
Regulation Mechanism				Transcription Factor Info
Naloxone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Naloxone inhibits the reaction SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[4]
Regulation Mechanism				Transcription Factor Info
Nialamide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Nialamide inhibits the reaction SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[4]
Regulation Mechanism				Transcription Factor Info
nickel sulfate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	nickel sulfate results in increased expression of SLC47A1 mRNA			[69]
Regulation Mechanism				Transcription Factor Info
Nicotinamide Mononucleotide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Nicotinamide Mononucleotide inhibits the reaction SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[4]
Regulation Mechanism				Transcription Factor Info
Nicotine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Nicotine inhibits the reaction SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[4]
Regulation Mechanism				Transcription Factor Info
nuciferine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	nuciferine inhibits the reaction SLC47A1 protein results in increased uptake of Metformin			[65]
Regulation Mechanism				Transcription Factor Info
Okadaic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Okadaic Acid results in decreased expression of SLC47A1 mRNA			[70]
Regulation Mechanism				Transcription Factor Info
Ondansetron	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ondansetron inhibits the reaction SLC47A1 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[50]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Ondansetron inhibits the reaction SLC47A1 protein results in increased uptake of Metformin			[66]
Regulation Mechanism				Transcription Factor Info
Oxaliplatin	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLC47A1 protein polymorphism results in decreased uptake of Oxaliplatin			[67]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	SLC47A1 protein polymorphism results in increased uptake of Oxaliplatin			[67]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	SLC47A1 protein results in increased uptake of Oxaliplatin			[67]
Regulation Mechanism				Transcription Factor Info
Oxygen	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Oxygen deficiency results in decreased expression of SLC47A1 mRNA			[71]
Regulation Mechanism				Transcription Factor Info
Phenformin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Phenformin inhibits the reaction SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[4]
Regulation Mechanism				Transcription Factor Info
Phentolamine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Phentolamine inhibits the reaction SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[4]
Regulation Mechanism				Transcription Factor Info
Progesterone	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Estradiol co-treated with Progesterone results in decreased expression of SLC47A1 mRNA			[61]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Progesterone co-treated with Estradiol results in increased expression of SLC47A1 mRNA			[63]
Regulation Mechanism				Transcription Factor Info
Proguanil	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Proguanil inhibits the reaction SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[4]
Regulation Mechanism				Transcription Factor Info
Propranolol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Propranolol inhibits the reaction SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[4]
Regulation Mechanism				Transcription Factor Info
Scopolamine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Scopolamine inhibits the reaction SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[4]
Regulation Mechanism				Transcription Factor Info
Serotonin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Serotonin inhibits the reaction SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[4]
Regulation Mechanism				Transcription Factor Info
sodium arsenite	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	sodium arsenite results in decreased expression of SLC47A1 mRNA			[40]
Regulation Mechanism				Transcription Factor Info
Sulfadimethoxine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sulfadimethoxine affects the reaction SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[4]
Regulation Mechanism				Transcription Factor Info
Sulfamerazine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sulfamerazine affects the reaction SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[4]
Regulation Mechanism				Transcription Factor Info
sulforaphane	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	sulforaphane results in increased expression of SLC47A1 mRNA			[43]
Regulation Mechanism				Transcription Factor Info
Tacrine	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tacrine inhibits the reaction SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[4]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Tacrine inhibits the reaction SLC47A1 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[50]
Regulation Mechanism				Transcription Factor Info
tetrabromobisphenol A	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	tetrabromobisphenol A inhibits the reaction SLC47A1 protein results in increased uptake of Tetraethylammonium			[39]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	tetrabromobisphenol A results in decreased activity of SLC47A1 protein			[39]
Regulation Mechanism				Transcription Factor Info
tetrabutylammonium	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	tetrabutylammonium inhibits the reaction SLC47A1 protein affects the uptake of Paraquat			[72]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	tetrabutylammonium inhibits the reaction SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[4]
Regulation Mechanism				Transcription Factor Info
Tetrachlorodibenzodioxin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tetrachlorodibenzodioxin results in decreased expression of SLC47A1 mRNA			[8]
Regulation Mechanism				Transcription Factor Info
Tetraethylammonium	14 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	bisphenol A inhibits the reaction SLC47A1 protein results in increased uptake of Tetraethylammonium			[39]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	bisphenol F inhibits the reaction SLC47A1 protein results in increased uptake of Tetraethylammonium			[39]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	bisphenol S inhibits the reaction SLC47A1 protein results in increased uptake of Tetraethylammonium			[39]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Pyrimethamine inhibits the reaction SLC47A1 protein results in increased uptake of Tetraethylammonium			[30]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	SLC47A1 protein affects the transport of Tetraethylammonium			[18]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	SLC47A1 protein polymorphism results in decreased uptake of Tetraethylammonium			[67]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	SLC47A1 protein results in increased import of Tetraethylammonium			[8]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	SLC47A1 protein results in increased uptake of Tetraethylammonium			[67]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	tetrabromobisphenol A inhibits the reaction SLC47A1 protein results in increased uptake of Tetraethylammonium			[39]
Regulation Mechanism				Transcription Factor Info
DT Modulation10	Tetraethylammonium inhibits the reaction SLC47A1 protein affects the uptake of Paraquat			[72]
Regulation Mechanism				Transcription Factor Info
DT Modulation11	Tetraethylammonium inhibits the reaction SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[4]
Regulation Mechanism				Transcription Factor Info
DT Modulation12	Tobacco Smoke Pollution inhibits the reaction SLC47A1 protein results in increased import of Tetraethylammonium			[8]
Regulation Mechanism				Transcription Factor Info
DT Modulation13	Verapamil inhibits the reaction SLC47A1 protein results in increased import of Tetraethylammonium			[8]
Regulation Mechanism				Transcription Factor Info
DT Modulation14	Verapamil inhibits the reaction SLC47A1 protein results in increased uptake of Tetraethylammonium			[39]
Regulation Mechanism				Transcription Factor Info
tetramethylammonium	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	tetramethylammonium affects the reaction SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[4]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	tetramethylammonium inhibits the reaction SLC47A1 protein affects the uptake of Paraquat			[72]
Regulation Mechanism				Transcription Factor Info
tetrapentylammonium	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	tetrapentylammonium inhibits the reaction SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[4]
Regulation Mechanism				Transcription Factor Info
tetrapropylammonium	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	tetrapropylammonium inhibits the reaction SLC47A1 protein affects the uptake of Paraquat			[72]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	tetrapropylammonium inhibits the reaction SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[4]
Regulation Mechanism				Transcription Factor Info
Ticlopidine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ticlopidine affects the reaction SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[4]
Regulation Mechanism				Transcription Factor Info
Topiramate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Topiramate affects the reaction SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[4]
Regulation Mechanism				Transcription Factor Info
Tramadol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tramadol inhibits the reaction SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[4]
Regulation Mechanism				Transcription Factor Info
Trichlormethiazide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Trichlormethiazide inhibits the reaction SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[4]
Regulation Mechanism				Transcription Factor Info
triethylmethylammonium	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	triethylmethylammonium inhibits the reaction SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[4]
Regulation Mechanism				Transcription Factor Info
Tyramine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tyramine inhibits the reaction SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[4]
Regulation Mechanism				Transcription Factor Info
Vanadates	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Vanadates results in decreased expression of SLC47A1 mRNA			[69]
Regulation Mechanism				Transcription Factor Info
zafirlukast	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	zafirlukast inhibits the reaction SLC47A1 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium			[50]
Regulation Mechanism				Transcription Factor Info
Herbicide
DT Modulation1	Paraquat inhibits the reaction SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[4]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	SLC47A1 protein affects the uptake of Paraquat			[72]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	SLC47A1 protein polymorphism results in decreased uptake of Paraquat			[67]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	SLC47A1 protein results in increased susceptibility to Paraquat			[72]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	SLC47A1 protein results in increased uptake of Paraquat			[67]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	tetrabutylammonium inhibits the reaction SLC47A1 protein affects the uptake of Paraquat			[72]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	Tetraethylammonium inhibits the reaction SLC47A1 protein affects the uptake of Paraquat			[72]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	tetramethylammonium inhibits the reaction SLC47A1 protein affects the uptake of Paraquat			[72]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	tetrapropylammonium inhibits the reaction SLC47A1 protein affects the uptake of Paraquat			[72]
Regulation Mechanism				Transcription Factor Info
Nanoparticle
perfluoro-n-nonanoic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	perfluoro-n-nonanoic acid results in decreased expression of SLC47A1 mRNA			[73]
Regulation Mechanism				Transcription Factor Info
Approved Drug
Ranitidine	5 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ranitidine inhibits the transportation of Metformin by SLC47A1 (IC50 = 18.9 microM)			[1]
Affected Drug/Substrate	Metformin	Modulation Type	Inhibition
Cell System	Human cervical cancer cell line (Hela)-MATE1
DT Modulation2	Ranitidine inhibits the transportation of Tetraethylammonium by SLC47A1 (IC50 = 17.5 microM)			[1]
Affected Drug/Substrate	Tetraethylammonium	Modulation Type	Inhibition
Cell System	Human cervical cancer cell line (Hela)-MATE1
DT Modulation3	Ranitidine inhibits the transportation of Tetraethylammonium by SLC47A1 (Ki = 25.4 microM)			[2]
Affected Drug/Substrate	Tetraethylammonium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MATE1
DT Modulation4	Ranitidine inhibits the transportation of 4-(4-(dimethylamino)styryl)-N-methylpyridinium by SLC47A1			[3]
Affected Drug/Substrate	4-(4-(dimethylamino)styryl)-N-methylpyridinium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MATE1
Quinine	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Quinine inhibits the transportation of 1-methyl-4-phenylpyridinium by SLC47A1 (IC50 = 1.9 microM)			[4]
Affected Drug/Substrate	1-methyl-4-phenylpyridinium	Modulation Type	Inhibition
Cell System	Chinese hamster ovary (CHO) cells-MATE1
DT Modulation2	Quinine inhibits the transportation of Tetraethylammonium by SLC47A1 (Ki = 29.2 microM)			[2]
Affected Drug/Substrate	Tetraethylammonium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MATE1
DT Modulation3	Quinine inhibits the transportation of 4-(4-(dimethylamino)styryl)-N-methylpyridinium by SLC47A1			[3]
Affected Drug/Substrate	4-(4-(dimethylamino)styryl)-N-methylpyridinium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MATE1
Ritonavir	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ritonavir inhibits the transportation of Metformin by SLC47A1 (IC50 = 15.4 microM)			[1]
Affected Drug/Substrate	Metformin	Modulation Type	Inhibition
Cell System	Human cervical cancer cell line (Hela)-MATE1
DT Modulation2	Ritonavir inhibits the transportation of Tetraethylammonium by SLC47A1 (IC50 = 13.9 microM)			[1]
Affected Drug/Substrate	Tetraethylammonium	Modulation Type	Inhibition
Cell System	Human cervical cancer cell line (Hela)-MATE1
DT Modulation3	Ritonavir inhibits the activity of SLC47A1 (IC50 = 3.1 microM)			[5]
Mitoxantrone	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Mitoxantrone inhibits the transportation of Metformin by SLC47A1 (IC50 = 4.4 microM)			[1]
Affected Drug/Substrate	Metformin	Modulation Type	Inhibition
Cell System	Human cervical cancer cell line (Hela)-MATE1
DT Modulation2	Mitoxantrone inhibits the transportation of Tetraethylammonium by SLC47A1 (IC50 = 5.2 microM)			[1]
Affected Drug/Substrate	Tetraethylammonium	Modulation Type	Inhibition
Cell System	Human cervical cancer cell line (Hela)-MATE1
Sirolimus	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Rapamycin inhibits the transportation of Metformin by SLC47A1 (IC50 = 3.27 microM)			[1]
Affected Drug/Substrate	Metformin	Modulation Type	Inhibition
Cell System	Human cervical cancer cell line (Hela)-MATE1
DT Modulation2	Rapamycin inhibits the transportation of Tetraethylammonium by SLC47A1 (IC50 = 3.51 microM)			[1]
Affected Drug/Substrate	Tetraethylammonium	Modulation Type	Inhibition
Cell System	Human cervical cancer cell line (Hela)-MATE1
Chloroquine	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Chloroquine inhibits the transportation of Metformin by SLC47A1 (IC50 = 2.5 microM)			[6]
Affected Drug/Substrate	Metformin	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MATE1
DT Modulation2	Chloroquine inhibits the activity of SLC47A1			[6]
Cimetidine	6 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cimetidine inhibits the transportation of Metformin by SLC47A1 (Ki = 3.8 microM)			[7]
Affected Drug/Substrate	Metformin	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MATE1
DT Modulation2	Cimetidine inhibits the transportation of Tetraethylammonium by SLC47A1 (Ki = 1.1 microM)			[2]
Affected Drug/Substrate	Tetraethylammonium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MATE1
Amantadine	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Amantadine inhibits the transportation of Tetraethylammonium by SLC47A1 (Ki = 111.8 microM)			[2]
Affected Drug/Substrate	Tetraethylammonium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MATE1
DT Modulation2	Amantadine inhibits the transportation of 4-(4-(dimethylamino)styryl)-N-methylpyridinium by SLC47A1			[3]
Affected Drug/Substrate	4-(4-(dimethylamino)styryl)-N-methylpyridinium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MATE1
Cetirizine	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cetirizine inhibits the transportation of Tetraethylammonium by SLC47A1 (Ki = 371.2 microM)			[2]
Affected Drug/Substrate	Tetraethylammonium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MATE1
DT Modulation2	Cetirizine inhibits the transportation of 4-(4-(dimethylamino)styryl)-N-methylpyridinium by SLC47A1			[3]
Affected Drug/Substrate	4-(4-(dimethylamino)styryl)-N-methylpyridinium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MATE1
Metformin	9 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Metformin inhibits the transportation of Tetraethylammonium by SLC47A1 (Ki = 666.9 microM)			[2]
Affected Drug/Substrate	Tetraethylammonium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MATE1
DT Modulation2	Metformin modulates the activity of SLC47A1			[11]
DT Modulation3	Cadmium inhibits the reaction SLC47A1 protein results in increased uptake of Metformin			[59]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Metformin inhibits the reaction SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[4]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	nuciferine inhibits the reaction SLC47A1 protein results in increased uptake of Metformin			[65]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Ondansetron inhibits the reaction SLC47A1 protein results in increased uptake of Metformin			[66]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	Pyrimethamine inhibits the reaction SLC47A1 protein results in increased uptake of Metformin			[4]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	SLC47A1 protein polymorphism results in decreased uptake of Metformin			[67]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	SLC47A1 protein results in increased uptake of Metformin			[67]
Regulation Mechanism				Transcription Factor Info
Carvedilol	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Carvedilol inhibits the activity of SLC47A1 (IC50 = 103 microM)			[10]
Cell System	Human embryonic kidney 293 cells (HEK293)-MATE1
DT Modulation2	Carvedilol inhibits the transportation of 4-(4-(dimethylamino)styryl)-N-methylpyridinium by SLC47A1			[3]
Affected Drug/Substrate	4-(4-(dimethylamino)styryl)-N-methylpyridinium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MATE1
Chlorpheniramine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Chlorpheniramine inhibits the transportation of Tetraethylammonium by SLC47A1 (Ki = 87.6 microM)			[2]
Affected Drug/Substrate	Tetraethylammonium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MATE1
Desipramine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Desipramine inhibits the transportation of Tetraethylammonium by SLC47A1 (Ki = 55.7 microM)			[2]
Affected Drug/Substrate	Tetraethylammonium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MATE1
Diltiazem	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Diltiazem inhibits the transportation of Tetraethylammonium by SLC47A1 (Ki = 12.5 microM)			[2]
Affected Drug/Substrate	Tetraethylammonium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MATE1
Diphenhydramine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Diphenhydramine inhibits the transportation of Tetraethylammonium by SLC47A1 (Ki = 87 microM)			[2]
Affected Drug/Substrate	Tetraethylammonium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MATE1
Disopyramide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Disopyramide inhibits the transportation of Tetraethylammonium by SLC47A1 (Ki = 83.8 microM)			[2]
Affected Drug/Substrate	Tetraethylammonium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MATE1
Famotidine	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Famotidine inhibits the transportation of Tetraethylammonium by SLC47A1 (Ki = 0.6 microM)			[2]
Affected Drug/Substrate	Tetraethylammonium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MATE1
Imipramine	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Imipramine inhibits the transportation of Tetraethylammonium by SLC47A1 (Ki = 42 microM)			[2]
Affected Drug/Substrate	Tetraethylammonium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MATE1
Pramipexole	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Pramipexole inhibits the transportation of Tetraethylammonium by SLC47A1 (Ki = 141.4 microM)			[2]
Affected Drug/Substrate	Tetraethylammonium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MATE1
Procainamide	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Procainamide inhibits the transportation of Tetraethylammonium by SLC47A1 (Ki = 217 microM)			[2]
Affected Drug/Substrate	Tetraethylammonium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MATE1
Verapamil	5 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Verapamil inhibits the transportation of Tetraethylammonium by SLC47A1 (Ki = 27.5 microM)			[2]
Affected Drug/Substrate	Tetraethylammonium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MATE1
Cobicistat	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cobicistat inhibits the activity of SLC47A1 (IC50 = 4.4 microM)			[5]
Telaprevir	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Telaprevir inhibits the activity of SLC47A1 (IC50 = 0.023 microM)			[15]
Azacitidine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Azacitidine inhibits the transportation of 4-(4-(dimethylamino)styryl)-N-methylpyridinium by SLC47A1			[3]
Affected Drug/Substrate	4-(4-(dimethylamino)styryl)-N-methylpyridinium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MATE1
Buspirone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Buspirone inhibits the transportation of 4-(4-(dimethylamino)styryl)-N-methylpyridinium by SLC47A1			[3]
Affected Drug/Substrate	4-(4-(dimethylamino)styryl)-N-methylpyridinium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MATE1
Chlorhexidine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Chlorhexidine inhibits the transportation of 4-(4-(dimethylamino)styryl)-N-methylpyridinium by SLC47A1			[3]
Affected Drug/Substrate	4-(4-(dimethylamino)styryl)-N-methylpyridinium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MATE1
Ciclopirox	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ciclopirox inhibits the transportation of 4-(4-(dimethylamino)styryl)-N-methylpyridinium by SLC47A1			[3]
Affected Drug/Substrate	4-(4-(dimethylamino)styryl)-N-methylpyridinium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MATE1
Clonidine	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Clonidine inhibits the transportation of 4-(4-(dimethylamino)styryl)-N-methylpyridinium by SLC47A1			[3]
Affected Drug/Substrate	4-(4-(dimethylamino)styryl)-N-methylpyridinium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MATE1
Cortisone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cortisone inhibits the transportation of 4-(4-(dimethylamino)styryl)-N-methylpyridinium by SLC47A1			[3]
Affected Drug/Substrate	4-(4-(dimethylamino)styryl)-N-methylpyridinium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MATE1
Dexamethasone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Dexamethasone inhibits the transportation of 4-(4-(dimethylamino)styryl)-N-methylpyridinium by SLC47A1			[3]
Affected Drug/Substrate	4-(4-(dimethylamino)styryl)-N-methylpyridinium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MATE1
Diclofenac	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Diclofenac inhibits the transportation of 4-(4-(dimethylamino)styryl)-N-methylpyridinium by SLC47A1			[3]
Affected Drug/Substrate	4-(4-(dimethylamino)styryl)-N-methylpyridinium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MATE1
Dihydroergotamine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Dihydroergotamine inhibits the transportation of 4-(4-(dimethylamino)styryl)-N-methylpyridinium by SLC47A1			[3]
Affected Drug/Substrate	4-(4-(dimethylamino)styryl)-N-methylpyridinium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MATE1
Domperidone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Domperidone inhibits the transportation of 4-(4-(dimethylamino)styryl)-N-methylpyridinium by SLC47A1			[3]
Affected Drug/Substrate	4-(4-(dimethylamino)styryl)-N-methylpyridinium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MATE1
Enalapril	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Enalapril inhibits the transportation of 4-(4-(dimethylamino)styryl)-N-methylpyridinium by SLC47A1			[3]
Affected Drug/Substrate	4-(4-(dimethylamino)styryl)-N-methylpyridinium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MATE1
Epinastine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Epinastine inhibits the transportation of 4-(4-(dimethylamino)styryl)-N-methylpyridinium by SLC47A1			[3]
Affected Drug/Substrate	4-(4-(dimethylamino)styryl)-N-methylpyridinium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MATE1
Erythromycin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Erythromycin inhibits the transportation of 4-(4-(dimethylamino)styryl)-N-methylpyridinium by SLC47A1			[3]
Affected Drug/Substrate	4-(4-(dimethylamino)styryl)-N-methylpyridinium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MATE1
Ethinyl Estradiol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ethinyl estradiol inhibits the transportation of 4-(4-(dimethylamino)styryl)-N-methylpyridinium by SLC47A1			[3]
Affected Drug/Substrate	4-(4-(dimethylamino)styryl)-N-methylpyridinium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MATE1
Furosemide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Furosemide inhibits the transportation of 4-(4-(dimethylamino)styryl)-N-methylpyridinium by SLC47A1			[3]
Affected Drug/Substrate	4-(4-(dimethylamino)styryl)-N-methylpyridinium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MATE1
Gabexate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Gabexate inhibits the transportation of 4-(4-(dimethylamino)styryl)-N-methylpyridinium by SLC47A1			[3]
Affected Drug/Substrate	4-(4-(dimethylamino)styryl)-N-methylpyridinium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MATE1
Granisetron	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Granisetron inhibits the transportation of 4-(4-(dimethylamino)styryl)-N-methylpyridinium by SLC47A1			[3]
Affected Drug/Substrate	4-(4-(dimethylamino)styryl)-N-methylpyridinium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MATE1
Indomethacin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Indomethacin inhibits the transportation of 4-(4-(dimethylamino)styryl)-N-methylpyridinium by SLC47A1			[3]
Affected Drug/Substrate	4-(4-(dimethylamino)styryl)-N-methylpyridinium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MATE1
Irbesartan	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Irbesartan inhibits the transportation of 4-(4-(dimethylamino)styryl)-N-methylpyridinium by SLC47A1			[3]
Affected Drug/Substrate	4-(4-(dimethylamino)styryl)-N-methylpyridinium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MATE1
Irinotecan	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Irinotecan inhibits the transportation of 4-(4-(dimethylamino)styryl)-N-methylpyridinium by SLC47A1			[3]
Affected Drug/Substrate	4-(4-(dimethylamino)styryl)-N-methylpyridinium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MATE1
Levofloxacin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Levofloxacin inhibits the transportation of 4-(4-(dimethylamino)styryl)-N-methylpyridinium by SLC47A1			[3]
Affected Drug/Substrate	4-(4-(dimethylamino)styryl)-N-methylpyridinium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MATE1
Lidocaine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Lidocaine inhibits the transportation of 4-(4-(dimethylamino)styryl)-N-methylpyridinium by SLC47A1			[3]
Affected Drug/Substrate	4-(4-(dimethylamino)styryl)-N-methylpyridinium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MATE1
Losartan	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Losartan inhibits the transportation of 4-(4-(dimethylamino)styryl)-N-methylpyridinium by SLC47A1			[3]
Affected Drug/Substrate	4-(4-(dimethylamino)styryl)-N-methylpyridinium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MATE1
Methylergonovine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Methylergonovine inhibits the transportation of 4-(4-(dimethylamino)styryl)-N-methylpyridinium by SLC47A1			[3]
Affected Drug/Substrate	4-(4-(dimethylamino)styryl)-N-methylpyridinium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MATE1
Prazosin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Prazosin inhibits the transportation of 4-(4-(dimethylamino)styryl)-N-methylpyridinium by SLC47A1			[3]
Affected Drug/Substrate	4-(4-(dimethylamino)styryl)-N-methylpyridinium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MATE1
Rimantadine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Rimantadine inhibits the transportation of 4-(4-(dimethylamino)styryl)-N-methylpyridinium by SLC47A1			[3]
Affected Drug/Substrate	4-(4-(dimethylamino)styryl)-N-methylpyridinium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MATE1
Spironolactone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Spironolactone inhibits the transportation of 4-(4-(dimethylamino)styryl)-N-methylpyridinium by SLC47A1			[3]
Affected Drug/Substrate	4-(4-(dimethylamino)styryl)-N-methylpyridinium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MATE1
Sulfacetamide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sulfacetamide inhibits the transportation of 4-(4-(dimethylamino)styryl)-N-methylpyridinium by SLC47A1			[3]
Affected Drug/Substrate	4-(4-(dimethylamino)styryl)-N-methylpyridinium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MATE1
Sumatriptan	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sumatriptan inhibits the transportation of 4-(4-(dimethylamino)styryl)-N-methylpyridinium by SLC47A1			[3]
Affected Drug/Substrate	4-(4-(dimethylamino)styryl)-N-methylpyridinium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MATE1
Telmisartan	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Telmisartan inhibits the transportation of 4-(4-(dimethylamino)styryl)-N-methylpyridinium by SLC47A1			[3]
Affected Drug/Substrate	4-(4-(dimethylamino)styryl)-N-methylpyridinium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MATE1
Thiabendazole	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Thiabendazole inhibits the transportation of 4-(4-(dimethylamino)styryl)-N-methylpyridinium by SLC47A1			[3]
Affected Drug/Substrate	4-(4-(dimethylamino)styryl)-N-methylpyridinium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MATE1
Topotecan	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Topotecan inhibits the transportation of 4-(4-(dimethylamino)styryl)-N-methylpyridinium by SLC47A1			[3]
Affected Drug/Substrate	4-(4-(dimethylamino)styryl)-N-methylpyridinium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MATE1
Tubocurarine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tubocurarine inhibits the transportation of 4-(4-(dimethylamino)styryl)-N-methylpyridinium by SLC47A1			[3]
Affected Drug/Substrate	4-(4-(dimethylamino)styryl)-N-methylpyridinium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MATE1
Zafirlukast	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Zafirlukast inhibits the transportation of 4-(4-(dimethylamino)styryl)-N-methylpyridinium by SLC47A1			[3]
Affected Drug/Substrate	4-(4-(dimethylamino)styryl)-N-methylpyridinium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MATE1
Crizotinib	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Crizotinib inhibits the transportation of Creatinine by SLC47A1			[16]
Affected Drug/Substrate	Creatinine	Modulation Type	Inhibition
Cell System	MATE1-overexpressing cells
Amiloride	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Amiloride inhibits the activity of SLC47A1			[18]
Quinidine	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Quinidine inhibits the activity of SLC47A1			[18]
Methotrexate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Methotrexate increases the expression of SLC47A1			[19]
Copper Sulfate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Copper Sulfate inhibits the expression of SLC47A1			[20]
Medroxyprogesterone Acetate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Medroxyprogesterone Acetate inhibits the expression of SLC47A1			[21]
Cytarabine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cytarabine inhibits the expression of SLC47A1			[22]
Zoledronic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Zoledronic Acid inhibits the expression of SLC47A1			[23]
Rifampin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Rifampin increases the expression of SLC47A1			[24]
Cisplatin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cisplatin increases the expression of SLC47A1			[25]
Mebendazole	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Mebendazole inhibits the expression of SLC47A1			[26]
Urethane	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Urethane inhibits the expression of SLC47A1			[27]
Acetaminophen	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Acetaminophen inhibits the expression of SLC47A1			[28]
Sunitinib	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sunitinib inhibits the expression of SLC47A1			[29]
Pyrimethamine	6 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Pyrimethamine inhibits the activity of SLC47A1			[30]
Cyclosporine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cyclosporine inhibits the expression of SLC47A1			[31]
Estradiol	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Estradiol increases the expression of SLC47A1			[32]
Valproic Acid	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Valproic Acid increases the expression of SLC47A1			[33]
Trimethoprim	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Trimethoprim inhibits the activity of SLC47A1			[6]
Plazomicin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Plazomicin inhibits the activity of SLC47A1			[34]
Itraconazole	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Itraconazole inhibits the activity of SLC47A1			[35]
Ketoconazole	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ketoconazole inhibits the activity of SLC47A1			[35]
Drug in Phase 4 Trial
Talipexole	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Talipexole inhibits the transportation of Tetraethylammonium by SLC47A1 (Ki = 66 microM)			[2]
Affected Drug/Substrate	Tetraethylammonium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MATE1
Drug in Phase 3 Trial
Vitamin E	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Vitamin E increases the expression of SLC47A1			[36]
Triclosan	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Triclosan inhibits the expression of SLC47A1			[41]
Sulforafan	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sulforafan increases the expression of SLC47A1			[43]
Drug in Phase 2 Trial
Camostat	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Camostat inhibits the transportation of 4-(4-(dimethylamino)styryl)-N-methylpyridinium by SLC47A1			[3]
Affected Drug/Substrate	4-(4-(dimethylamino)styryl)-N-methylpyridinium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MATE1
MS-275	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	MS-275 increases the expression of SLC47A1			[38]
Bisphenol A	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Bisphenol A inhibits the activity of SLC47A1			[39]
Drug in Phase 1/2 Trial
CB3304	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	CB3304 inhibits the transportation of 4-(4-(dimethylamino)styryl)-N-methylpyridinium by SLC47A1			[3]
Affected Drug/Substrate	4-(4-(dimethylamino)styryl)-N-methylpyridinium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MATE1
Drug in Phase 1 Trial
Sodium arsenite	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sodium arsenite inhibits the expression of SLC47A1			[40]
Discontinued Drug
DX-619	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	DX-619 inhibits the transportation of Creatinine by SLC47A1 (Ki = 0.82 microM)			[12]
Affected Drug/Substrate	Creatinine	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MATE1
Patented Pharmaceutical Agent
ICG-001	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	ICG-001 increases the expression of SLC47A1			[37]
Drug Withdrawn
Astemizole	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Astemizole inhibits the transportation of 4-(4-(dimethylamino)styryl)-N-methylpyridinium by SLC47A1			[3]
Affected Drug/Substrate	4-(4-(dimethylamino)styryl)-N-methylpyridinium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MATE1
Bithionol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Bithionol inhibits the transportation of 4-(4-(dimethylamino)styryl)-N-methylpyridinium by SLC47A1			[3]
Affected Drug/Substrate	4-(4-(dimethylamino)styryl)-N-methylpyridinium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MATE1
Phenacetin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Phenacetin inhibits the transportation of 4-(4-(dimethylamino)styryl)-N-methylpyridinium by SLC47A1			[3]
Affected Drug/Substrate	4-(4-(dimethylamino)styryl)-N-methylpyridinium	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MATE1
Natural Product
Cigarette smoke condensate	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cigarette smoke condensate inhibits the transportation of Verapamil by repressing mRNA expression of SLC47A1 (IC50 = 6.1 microM)			[8]
Affected Drug/Substrate	Verapamil	Modulation Type	Inhibition
Cell System	Human hepatoma HepaRG cells-MATE1
DT Modulation2	Cigarette smoke condensate inhibits the activity of SLC47A1 (IC50 = 6.1 microM)			[9]
Cell System	Human embryonic kidney 293 cells (HEK293)-MATE1
Allethrin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Allethrin inhibits the transportation of Verapamil by SLC47A1 (IC50 = 50.2 microM)			[13]
Affected Drug/Substrate	Verapamil	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MATE1
Tetramethrin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tetramethrin inhibits the transportation of Verapamil by SLC47A1 (IC50 = 47.5 microM)			[13]
Affected Drug/Substrate	Verapamil	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MATE1
3-methylquercetin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Isorhamnetin inhibits the transportation of Tetraethylammonium by SLC47A1 (Ki = 0.32 microM)			[14]
Affected Drug/Substrate	Tetraethylammonium	Modulation Type	Inhibition
Green tea	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Green tea inhibits the transportation of Metformin by SLC47A1			[17]
Affected Drug/Substrate	Metformin	Modulation Type	Inhibition
Cell System	Human enterocyte-like 2 cell (Caco-2)-MATE1
Epigallocatechin gallate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Epigallocatechin gallate inhibits the transportation of Metformin by SLC47A1			[17]
Affected Drug/Substrate	Metformin	Modulation Type	Inhibition
Cell System	Human embryonic kidney 293 cells (HEK293)-MATE1
Methyleugenol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Methyleugenol inhibits the expression of SLC47A1			[44]
Tobacco Smoke Pollution	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tobacco Smoke Pollution inhibits the expression of SLC47A1			[47]
Rhein	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Rhein up-regulated the expressions of SLC47A1			[48]
Cell System	NRK-52E cells
Caffeine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Caffeine affects the reaction SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium			[4]
Regulation Mechanism				Transcription Factor Info
Environmental toxicant
Polychlorinated dibenzodioxin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Polychlorinated dibenzodioxin inhibits the expression of SLC47A1			[8]
Tetrabromobisphenol A	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tetrabromobisphenol A inhibits the activity of SLC47A1			[39]
Mycotoxins
Aflatoxin B1	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Aflatoxin B1 inhibits the expression of SLC47A1			[46]
DT Modulation2	Aflatoxin B1 affects the expression of SLC47A1 protein			[54]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Aflatoxin B1 results in increased methylation of SLC47A1 gene			[46]
Regulation Mechanism				Transcription Factor Info
Acute Toxic Substance
Paraquat	10 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Paraquat increases the expression of SLC47A1			[45]
Carcinogen
Benzo(a)pyrene	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Benzo(a)pyrene inhibits the expression of SLC47A1			[44]
Arsenic	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Arsenic affects the methylation of SLC47A1 gene			[55]
Regulation Mechanism				Transcription Factor Info
Cadmium	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cadmium inhibits the reaction SLC47A1 protein results in increased uptake of Metformin			[59]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Cimetidine inhibits the reaction SLC47A1 protein results in increased uptake of Cadmium			[59]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	SLC47A1 protein results in increased susceptibility to Cadmium			[59]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	SLC47A1 protein results in increased uptake of Cadmium			[59]
Regulation Mechanism				Transcription Factor Info
Nickel	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Nickel results in decreased expression of SLC47A1 mRNA			[68]
Regulation Mechanism				Transcription Factor Info
Health and Environmental Toxicant
1-methyl-4-phenylpyridinium	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	1-methyl-4-phenylpyridinium inhibits the activity of SLC47A1			[18]
Diethylhexyl Phthalate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Diethylhexyl Phthalate inhibits the expression of SLC47A1			[42]

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