Detail Information of Exogenous Modulation

General Information of Drug Transporter (DT)
DT ID	DTD0005 Transporter Info
Gene Name	SLC22A7
Transporter Name	Organic anion transporter 2
Gene ID	10864
UniProt ID	Q9Y694

Exogenous factors (drugs, dietary constituents, etc.) Modulation of This DT (EGM)
Chemical Compound
DT Modulation1	Ketoprofen results in decreased activity of SLC22A7 protein			[2]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Bumetanide inhibits the reaction SLC22A7 protein results in increased transport of Tetracycline			[35]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	SLC22A7 protein results in increased transport of Bumetanide			[35]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Furosemide inhibits the reaction SLC22A7 protein results in increased transport of Tetracycline			[35]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Diclofenac inhibits the reaction SLC22A7 protein results in increased transport of Tetracycline			[35]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Diclofenac results in decreased activity of SLC22A7 protein			[2]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Indomethacin inhibits the reaction SLC22A7 protein results in increased transport of Tetracycline			[35]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Indomethacin results in decreased activity of SLC22A7 protein			[2]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Mefenamic Acid results in decreased activity of SLC22A7 protein			[2]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Naproxen results in decreased activity of SLC22A7 protein			[2]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Piroxicam results in decreased activity of SLC22A7 protein			[2]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Sulindac results in decreased activity of SLC22A7 protein			[2]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Phenacetin results in decreased activity of SLC22A7 protein			[2]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Minocycline inhibits the reaction SLC22A7 protein results in increased uptake of Anions			[10]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Oxytetracycline inhibits the reaction SLC22A7 protein results in increased uptake of Anions			[10]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	SLC22A7 protein results in increased uptake of Zidovudine			[35]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Zidovudine results in increased expression of SLC22A7 mRNA			[47]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	SLC22A7 protein results in increased uptake of Methotrexate			[35]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Valproic Acid affects the expression of SLC22A7 mRNA			[46]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Erythromycin inhibits the reaction SLC22A7 protein results in increased transport of Tetracycline			[35]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Salicylic Acid promotes the reaction SLC22A7 protein results in increased export of Orotic Acid			[34]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Salicylic Acid results in decreased activity of SLC22A7 protein			[2]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	SLC22A7 protein results in increased uptake of Salicylic Acid			[2]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Estradiol results in decreased expression of SLC22A7 mRNA			[36]
Regulation Mechanism				Transcription Factor Info
DT Modulation1	Benzo(a)pyrene results in increased methylation of SLC22A7 promoter			[38]
Regulation Mechanism				Transcription Factor Info
1-Naphthylisothiocyanate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	1-Naphthylisothiocyanate co-treated with Cholic Acids affects the expression of SLC22A7 mRNA			[33]
Regulation Mechanism				Transcription Factor Info
4-Aminobenzoic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	4-Aminobenzoic Acid promotes the reaction SLC22A7 protein results in increased export of Orotic Acid			[34]
Regulation Mechanism				Transcription Factor Info
Allopurinol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLC22A7 protein results in increased transport of Allopurinol			[35]
Regulation Mechanism				Transcription Factor Info
Ascorbic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLC22A7 protein results in increased transport of Ascorbic Acid			[35]
Regulation Mechanism				Transcription Factor Info
Benzoic Acid	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Benzoic Acid promotes the reaction SLC22A7 protein results in increased export of Orotic Acid			[34]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Orotic Acid co-treated with Benzoic Acid promotes the reaction SLC22A7 protein results in increased export of Orotic Acid			[34]
Regulation Mechanism				Transcription Factor Info
bisphenol A	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	bisphenol A affects the expression of SLC22A7 mRNA			[31]
Regulation Mechanism				Transcription Factor Info
Cadmium Chloride	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cadmium Chloride results in increased abundance of Cadmium which results in decreased expression of SLC22A7 mRNA			[39]
Regulation Mechanism				Transcription Factor Info
Chenodeoxycholic Acid	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Chenodeoxycholic Acid results in decreased expression of SLC22A7 mRNA			[40]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Tartrazine co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid results in decreased expression of SLC22A7 mRNA			[41]
Regulation Mechanism				Transcription Factor Info
Chloramphenicol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Chloramphenicol inhibits the reaction SLC22A7 protein results in increased transport of Tetracycline			[35]
Regulation Mechanism				Transcription Factor Info
Chlorpromazine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Chlorpromazine co-treated with Cholic Acids affects the expression of SLC22A7 mRNA			[33]
Regulation Mechanism				Transcription Factor Info
Cimetidine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLC22A7 protein results in increased uptake of Cimetidine			[42]
Regulation Mechanism				Transcription Factor Info
cinnamic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	cinnamic acid promotes the reaction SLC22A7 protein results in increased export of Orotic Acid			[34]
Regulation Mechanism				Transcription Factor Info
Dehydroepiandrosterone Sulfate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLC22A7 protein results in increased transport of Dehydroepiandrosterone Sulfate			[35]
Regulation Mechanism				Transcription Factor Info
Deoxycholic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tartrazine co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid results in decreased expression of SLC22A7 mRNA			[41]
Regulation Mechanism				Transcription Factor Info
Desipramine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Desipramine inhibits the reaction SLC22A7 protein results in increased uptake of Rhodamine 123			[43]
Regulation Mechanism				Transcription Factor Info
Dinoprost	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLC22A7 protein results in increased uptake of Dinoprost			[35]
Regulation Mechanism				Transcription Factor Info
Dinoprostone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLC22A7 protein results in increased transport of Dinoprostone			[35]
Regulation Mechanism				Transcription Factor Info
estrone sulfate	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Fumarates promotes the reaction SLC22A7 protein results in increased uptake of estrone sulfate			[35]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	SLC22A7 protein results in increased uptake of estrone sulfate			[35]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Succinates promotes the reaction SLC22A7 protein results in increased uptake of estrone sulfate			[35]
Regulation Mechanism				Transcription Factor Info
Ethinyl Estradiol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ethinyl Estradiol co-treated with Cholic Acids affects the expression of SLC22A7 mRNA			[33]
Regulation Mechanism				Transcription Factor Info
Fluorouracil	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLC22A7 protein results in increased transport of Fluorouracil			[35]
Regulation Mechanism				Transcription Factor Info
Fumarates	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Fumarates promotes the reaction SLC22A7 protein results in increased uptake of estrone sulfate			[35]
Regulation Mechanism				Transcription Factor Info
gamma-Aminobutyric Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	gamma-Aminobutyric Acid promotes the reaction SLC22A7 protein results in increased export of Orotic Acid			[34]
Regulation Mechanism				Transcription Factor Info
Glycochenodeoxycholic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tartrazine co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid results in decreased expression of SLC22A7 mRNA			[41]
Regulation Mechanism				Transcription Factor Info
Glycocholic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tartrazine co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid results in decreased expression of SLC22A7 mRNA			[41]
Regulation Mechanism				Transcription Factor Info
Glycodeoxycholic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tartrazine co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid results in decreased expression of SLC22A7 mRNA			[41]
Regulation Mechanism				Transcription Factor Info
GW 501516	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	GW 501516 binds to PPARD protein which results in increased expression of SLC22A7 mRNA			[44]
Regulation Mechanism				Transcription Factor Info
heliotrine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	heliotrine results in decreased expression of SLC22A7 mRNA			[26]
Regulation Mechanism				Transcription Factor Info
methyleugenol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	methyleugenol results in decreased expression of SLC22A7 mRNA			[32]
Regulation Mechanism				Transcription Factor Info
Methyltestosterone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Methyltestosterone co-treated with Cholic Acids affects the expression of SLC22A7 mRNA			[33]
Regulation Mechanism				Transcription Factor Info
Niacin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Niacin promotes the reaction SLC22A7 protein results in increased export of Orotic Acid			[34]
Regulation Mechanism				Transcription Factor Info
Niclosamide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Niclosamide inhibits the reaction SLC22A7 protein results in increased uptake of Rhodamine 123			[43]
Regulation Mechanism				Transcription Factor Info
N-Nitrosopyrrolidine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	N-Nitrosopyrrolidine results in decreased expression of SLC22A7 mRNA			[32]
Regulation Mechanism				Transcription Factor Info
Okadaic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Okadaic Acid results in decreased expression of SLC22A7 mRNA			[45]
Regulation Mechanism				Transcription Factor Info
oltipraz	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	oltipraz results in decreased expression of SLC22A7 mRNA			[12]
Regulation Mechanism				Transcription Factor Info
Orotic Acid	10 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	4-Aminobenzoic Acid promotes the reaction SLC22A7 protein results in increased export of Orotic Acid			[34]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Benzoic Acid promotes the reaction SLC22A7 protein results in increased export of Orotic Acid			[34]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	cinnamic acid promotes the reaction SLC22A7 protein results in increased export of Orotic Acid			[34]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	gamma-Aminobutyric Acid promotes the reaction SLC22A7 protein results in increased export of Orotic Acid			[34]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Niacin promotes the reaction SLC22A7 protein results in increased export of Orotic Acid			[34]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Orotic Acid co-treated with Benzoic Acid promotes the reaction SLC22A7 protein results in increased export of Orotic Acid			[34]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	Orotic Acid promotes the reaction SLC22A7 protein results in increased export of Orotic Acid			[34]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	phenylpyruvic acid promotes the reaction SLC22A7 protein results in increased export of Orotic Acid			[34]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	Salicylic Acid promotes the reaction SLC22A7 protein results in increased export of Orotic Acid			[34]
Regulation Mechanism				Transcription Factor Info
DT Modulation10	SLC22A7 protein results in increased export of Orotic Acid			[34]
Regulation Mechanism				Transcription Factor Info
Paclitaxel	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLC22A7 protein results in increased transport of Paclitaxel			[35]
Regulation Mechanism				Transcription Factor Info
p-Aminohippuric Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLC22A7 protein results in increased uptake of p-Aminohippuric Acid			[35]
Regulation Mechanism				Transcription Factor Info
phenylpyruvic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	phenylpyruvic acid promotes the reaction SLC22A7 protein results in increased export of Orotic Acid			[34]
Regulation Mechanism				Transcription Factor Info
Ranitidine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	SLC22A7 protein results in increased uptake of Ranitidine			[42]
Regulation Mechanism				Transcription Factor Info
Rhodamine 123	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Desipramine inhibits the reaction SLC22A7 protein results in increased uptake of Rhodamine 123			[43]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Niclosamide inhibits the reaction SLC22A7 protein results in increased uptake of Rhodamine 123			[43]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	SLC22A7 protein results in increased uptake of Rhodamine 123			[43]
Regulation Mechanism				Transcription Factor Info
senecionine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	senecionine results in decreased expression of SLC22A7 mRNA			[26]
Regulation Mechanism				Transcription Factor Info
senkirkine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	senkirkine results in decreased expression of SLC22A7 mRNA			[26]
Regulation Mechanism				Transcription Factor Info
sodium arsenite	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	sodium arsenite results in decreased expression of SLC22A7 mRNA			[29]
Regulation Mechanism				Transcription Factor Info
Tartrazine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tartrazine co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid results in decreased expression of SLC22A7 mRNA			[41]
Regulation Mechanism				Transcription Factor Info
Tetrachlorodibenzodioxin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Endosulfan co-treated with Tetrachlorodibenzodioxin results in decreased expression of SLC22A7 mRNA			[27]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Tetrachlorodibenzodioxin results in decreased expression of SLC22A7 mRNA			[12]
Regulation Mechanism				Transcription Factor Info
Tetracycline	11 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Acetaminophen inhibits the reaction SLC22A7 protein results in increased transport of Tetracycline			[35]
Regulation Mechanism				Transcription Factor Info
DT Modulation2	Bumetanide inhibits the reaction SLC22A7 protein results in increased transport of Tetracycline			[35]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Chloramphenicol inhibits the reaction SLC22A7 protein results in increased transport of Tetracycline			[35]
Regulation Mechanism				Transcription Factor Info
DT Modulation4	Diclofenac inhibits the reaction SLC22A7 protein results in increased transport of Tetracycline			[35]
Regulation Mechanism				Transcription Factor Info
DT Modulation5	Erythromycin inhibits the reaction SLC22A7 protein results in increased transport of Tetracycline			[35]
Regulation Mechanism				Transcription Factor Info
DT Modulation6	Furosemide inhibits the reaction SLC22A7 protein results in increased transport of Tetracycline			[35]
Regulation Mechanism				Transcription Factor Info
DT Modulation7	Ibuprofen inhibits the reaction SLC22A7 protein results in increased transport of Tetracycline			[35]
Regulation Mechanism				Transcription Factor Info
DT Modulation8	Indomethacin inhibits the reaction SLC22A7 protein results in increased transport of Tetracycline			[35]
Regulation Mechanism				Transcription Factor Info
DT Modulation9	SLC22A7 protein results in increased transport of Tetracycline			[35]
Regulation Mechanism				Transcription Factor Info
DT Modulation10	SLC22A7 protein results in increased uptake of Tetracycline			[10]
Regulation Mechanism				Transcription Factor Info
DT Modulation11	Tetracycline inhibits the reaction SLC22A7 protein results in increased uptake of Anions			[10]
Regulation Mechanism				Transcription Factor Info
Approved Drug
Probenecid	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Probenecid inhibits the transportation of Prostaglandin F2alpha by SLC22A7 (Ki = 766 microM)			[1]
Affected Drug/Substrate	Prostaglandin F2alpha	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT2
DT Modulation2	Probenecid inhibits the activity of SLC22A7			[1]
Ketoprofen	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ketoprofen inhibits the transportation of Prostaglandin F2alpha by SLC22A7 (IC50 = 400 microM)			[2]
Affected Drug/Substrate	Prostaglandin F2alpha	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT2
DT Modulation2	Ketoprofen inhibits the transportation of Salicylate by SLC22A7 (IC50 = 400 microM)			[3]
Affected Drug/Substrate	Salicylate	Modulation Type	Inhibition
Theophylline	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Theophylline inhibits the transportation of Erythromycin by SLC22A7			[4]
Affected Drug/Substrate	Erythromycin	Modulation Type	Inhibition
Cell System	Oocytes-OAT2
DT Modulation2	Theophylline inhibits the activity of SLC22A7			[4]
Bumetanide	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Bumetanide inhibits the transportation of Prostaglandin F2alpha by SLC22A7 (IC50 = 77.5 microM)			[6]
Affected Drug/Substrate	Prostaglandin F2alpha	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT2
Chlorothiazide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Chlorothiazide inhibits the transportation of Prostaglandin F2alpha by SLC22A7 (IC50 = 2205 microM)			[6]
Affected Drug/Substrate	Prostaglandin F2alpha	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT2
Cyclothiazide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cyclothiazide inhibits the transportation of Prostaglandin F2alpha by SLC22A7 (IC50 = 39.2 microM)			[6]
Affected Drug/Substrate	Prostaglandin F2alpha	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT2
Ethacrynic Acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ethacrynic acid inhibits the transportation of Prostaglandin F2alpha by SLC22A7 (IC50 = 121 microM)			[6]
Affected Drug/Substrate	Prostaglandin F2alpha	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT2
Furosemide	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Furosemide inhibits the transportation of Prostaglandin F2alpha by SLC22A7 (IC50 = 603 microM)			[6]
Affected Drug/Substrate	Prostaglandin F2alpha	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT2
Hydrochlorothiazide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Hydrochlorothiazide inhibits the transportation of Prostaglandin F2alpha by SLC22A7 (IC50 = 1023 microM)			[6]
Affected Drug/Substrate	Prostaglandin F2alpha	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT2
Trichlormethiazide	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Trichloromethiazide inhibits the transportation of Prostaglandin F2alpha by SLC22A7 (IC50 = 1120 microM)			[6]
Affected Drug/Substrate	Prostaglandin F2alpha	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT2
Diclofenac	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Diclofenac inhibits the transportation of Prostaglandin F2alpha by SLC22A7 (IC50 = 14.3 microM)			[2]
Affected Drug/Substrate	Prostaglandin F2alpha	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT2
Ibuprofen	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Ibuprofen inhibits the transportation of Prostaglandin F2alpha by SLC22A7 (IC50 = 692 microM)			[2]
Affected Drug/Substrate	Prostaglandin F2alpha	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT2
DT Modulation2	Ibuprofen inhibits the reaction SLC22A7 protein results in increased transport of Tetracycline			[35]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Ibuprofen results in decreased activity of SLC22A7 protein			[2]
Regulation Mechanism				Transcription Factor Info
Indomethacin	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Indomethacin inhibits the transportation of Prostaglandin F2alpha by SLC22A7 (IC50 = 64.1 microM)			[2]
Affected Drug/Substrate	Prostaglandin F2alpha	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT2
Mefenamic Acid	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Mefenamic acid inhibits the transportation of Prostaglandin F2alpha by SLC22A7 (IC50 = 21.7 microM)			[2]
Affected Drug/Substrate	Prostaglandin F2alpha	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT2
Naproxen	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Naproxen inhibits the transportation of Prostaglandin F2alpha by SLC22A7 (IC50 = 486 microM)			[2]
Affected Drug/Substrate	Prostaglandin F2alpha	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT2
Piroxicam	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Piroxicam inhibits the transportation of Prostaglandin F2alpha by SLC22A7 (IC50 = 70.3 microM)			[2]
Affected Drug/Substrate	Prostaglandin F2alpha	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT2
Sulindac	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sulindac inhibits the transportation of Prostaglandin F2alpha by SLC22A7 (IC50 = 440 microM)			[2]
Affected Drug/Substrate	Prostaglandin F2alpha	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT2
Cefamandole	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cefamandole inhibits the transportation of Prostaglandin F2alpha by SLC22A7 (IC50 = 1570 microM)			[7]
Affected Drug/Substrate	Prostaglandin F2alpha	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT2
Cefoperazone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cefoperazone inhibits the transportation of Prostaglandin F2alpha by SLC22A7 (IC50 = 1330 microM)			[7]
Affected Drug/Substrate	Prostaglandin F2alpha	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT2
Cefotaxime	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cefotaxime inhibits the transportation of Prostaglandin F2alpha by SLC22A7 (IC50 = 4680 microM)			[7]
Affected Drug/Substrate	Prostaglandin F2alpha	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT2
Cephalothin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cephalothin inhibits the transportation of Prostaglandin F2alpha by SLC22A7 (IC50 = 1410 microM)			[7]
Affected Drug/Substrate	Prostaglandin F2alpha	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT2
Vorinostat	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Vorinostat inhibits histone deacetylases, which then enhances the expression of SLC22A7, and enhances zidovudine's transportation			[8]
Affected Drug/Substrate	zidovudine	Modulation Type	Inducer
Cell System	Hepatocellular carcinoma cell lines (BEL-7402 and SMMC-7721)
Minocycline	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Minocycline inhibits the transportation of Prostaglandin F2alpha by SLC22A7			[10]
Affected Drug/Substrate	Prostaglandin F2alpha	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT2
Oxytetracycline	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Oxytetracycline inhibits the transportation of Prostaglandin F2alpha by SLC22A7			[10]
Affected Drug/Substrate	Prostaglandin F2alpha	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT2
Zidovudine	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Zidovudine inhibits the transportation of Prostaglandin F2alpha by SLC22A7			[11]
Affected Drug/Substrate	Prostaglandin F2alpha	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT2
Phenobarbital	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Phenobarbital inhibits the expression of SLC22A7			[12]
Regulation Mechanism	via modulation of Nuclear receptor subfamily 1 group I member 3 (NR1I3)			Transcription Factor Info
Cell System	Human primary human hepatocytes
Rifampin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Rifampin inhibits the expression of SLC22A7			[12]
Regulation Mechanism	via modulation of Nuclear receptor subfamily 1 group I member 2 (NR1I2)			Transcription Factor Info
Cell System	Human primary human hepatocytes
Chenodeoxycholic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Chenodeoxycholic acid inhibits the expression of SLC22A7			[13]
Regulation Mechanism	via the inhibition of Hepatocyte nuclear factor 4-alpha (HNF4A)			Transcription Factor Info
Cell System	Human adult hepatocellular carcinoma cells (Huh7)
Aspirin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Aspirin inhibits the activity of SLC22A7			[2]
DT Modulation2	Aspirin results in decreased activity of SLC22A7 protein			[2]
Regulation Mechanism				Transcription Factor Info
Methotrexate	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Methotrexate increases the expression of SLC22A7			[14]
Rosiglitazone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Rosiglitazone inhibits the expression of SLC22A7			[15]
Urethane	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Urethane inhibits the expression of SLC22A7			[16]
Valproic Acid	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Valproic Acid inhibits the expression of SLC22A7			[17]
Tamoxifen	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tamoxifen increases the expression of SLC22A7			[18]
Bosentan	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Bosentan affects the expression of SLC22A7			[19]
Cyclosporine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cyclosporine inhibits the expression of SLC22A7			[20]
Acetaminophen	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Acetaminophen inhibits the expression of SLC22A7			[21]
DT Modulation2	Acetaminophen inhibits the reaction SLC22A7 protein results in increased transport of Tetracycline			[35]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Acetaminophen results in decreased activity of SLC22A7 protein			[2]
Regulation Mechanism				Transcription Factor Info
Erythromycin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Erythromycin inhibits the activity of SLC22A7			[4]
Salicylic Acid	4 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Salicylic acid inhibits the activity of SLC22A7			[22]
Estradiol	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Estradiol induces the activity of SLC22A7			[23]
Drug in Phase 3 Trial
Oltipraz	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Oltipraz inhibits the expression of SLC22A7			[12]
Drug in Phase 2 Trial
Bisphenol A	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Bisphenol A affects the expression of SLC22A7			[31]
Drug in Phase 1 Trial
Sodium arsenite	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Sodium arsenite inhibits the expression of SLC22A7			[29]
Drug Withdrawn
Phenacetin	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Phenacetin inhibits the transportation of Prostaglandin F2alpha by SLC22A7 (IC50 = 1878 microM)			[2]
Affected Drug/Substrate	Prostaglandin F2alpha	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT2
Cephaloridine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cephaloridine inhibits the transportation of Prostaglandin F2alpha by SLC22A7 (IC50 = 4480 microM)			[7]
Affected Drug/Substrate	Prostaglandin F2alpha	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT2
Natural Product
Cigarette smoke condensate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cigarette smoke condensate inhibits the activity of SLC22A7 (IC50 = 16.9 microM)			[9]
Cell System	Human hepatoma HepaRG cells-OAT2
Coal Ash	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Coal Ash increases the expression of SLC22A7			[24]
Particulate Matter	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Particulate Matter inhibits the expression of SLC22A7			[25]
Heliotrine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Heliotrine inhibits the expression of SLC22A7			[26]
Senecionine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Senecionine inhibits the expression of SLC22A7			[26]
Tobacco Smoke Pollution	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tobacco Smoke Pollution inhibits the expression of SLC22A7			[9]
Methyleugenol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Methyleugenol inhibits the expression of SLC22A7			[32]
Environmental toxicant
Polychlorinated dibenzodioxin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Polychlorinated dibenzodioxin inhibits the expression of SLC22A7			[9]
Mycotoxins
Aflatoxin B1	3 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Aflatoxin B1 inhibits the transportation of Organic anion by SLC22A7 (IC50 = 1502 microM)			[5]
Affected Drug/Substrate	Organic anion	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT2
DT Modulation2	Aflatoxin B1 affects the expression of SLC22A7 protein			[36]
Regulation Mechanism				Transcription Factor Info
DT Modulation3	Aflatoxin B1 results in decreased expression of SLC22A7 mRNA			[37]
Regulation Mechanism				Transcription Factor Info
Alpha-zearalenol	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Alpha-zearalenol inhibits the transportation of Organic anion by SLC22A7 (IC50 = 180 microM)			[5]
Affected Drug/Substrate	Organic anion	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT2
Citrioveridine	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Citrioveridine inhibits the transportation of Organic anion by SLC22A7 (IC50 > 1000 microM)			[5]
Affected Drug/Substrate	Organic anion	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT2
Cyclopiazonic acid	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cyclopiazonic acid inhibits the transportation of Organic anion by SLC22A7 (IC50 = 126 microM)			[5]
Affected Drug/Substrate	Organic anion	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT2
Fumonisin B1	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Fumonisin B1 inhibits the transportation of Organic anion by SLC22A7			[5]
Affected Drug/Substrate	Organic anion	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT2
Patulin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Patulin inhibits the transportation of Organic anion by SLC22A7			[5]
Affected Drug/Substrate	Organic anion	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT2
Gliotoxin	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Gliotoxin inhibits the transportation of Organic anion by SLC22A7			[5]
Affected Drug/Substrate	Organic anion	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT2
Zearalenone	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Zearalenone inhibits the transportation of Organic anion by SLC22A7 (IC50 = 149 microM)			[5]
Affected Drug/Substrate	Organic anion	Modulation Type	Inhibition
Cell System	The Proximal Tubule (S2) Cells-OAT2
Carcinogen
Benzo(a)pyrene	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Benzo(a)pyrene inhibits the expression of SLC22A7			[32]
Cadmium	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Cadmium Chloride results in increased abundance of Cadmium which results in decreased expression of SLC22A7 mRNA			[39]
Regulation Mechanism				Transcription Factor Info
Fungicide
Tebuconazole	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Tebuconazole inhibits the expression of SLC22A7			[30]
tebuconazole	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	tebuconazole results in decreased expression of SLC22A7 mRNA			[30]
Regulation Mechanism				Transcription Factor Info
Pesticide/Insecticide
Endosulfan	2 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	Endosulfan inhibits the expression of SLC22A7			[27]
Health and Environmental Toxicant
DT Modulation1	Endosulfan co-treated with Tetrachlorodibenzodioxin results in decreased expression of SLC22A7 mRNA			[27]
Regulation Mechanism				Transcription Factor Info
tris(1,3-dichloro-2-propyl)phosphate	1 DT Activity Modulations Related to This Exogenous Factor		Click to Show/Hide the Full List
DT Modulation1	tris(1,3-dichloro-2-propyl)phosphate inhibits the expression of SLC22A7			[28]

References
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2	Interactions of human organic anion transporters and human organic cation transporters with nonsteroidal anti-inflammatory drugs. J Pharmacol Exp Ther. 2002 Nov;303(2):534-9.
3	Characterization of Organic Anion Transporter 2 (SLC22A7): A Highly Efficient Transporter for Creatinine and Species-Dependent Renal Tubular Expression. Drug Metab Dispos. 2015 Jul;43(7):984-93.
4	Possible involvement of organic anion transporter 2 on the interaction of theophylline with erythromycin in the human liver. Drug Metab Dispos. 2005 May;33(5):619-22.
5	Interactions of organic anion transporters and organic cation transporters with mycotoxins. J Pharmacol Sci. 2008 Mar;106(3):435-43.
6	Interactions of human organic anion transporters with diuretics. J Pharmacol Exp Ther. 2004 Mar;308(3):1021-9.
7	Interaction of human and rat organic anion transporter 2 with various cephalosporin antibiotics. Eur J Pharmacol. 2003 Mar 28;465(1-2):1-7.
8	Proteomic and Biochemical Studies of Lysine Malonylation Suggest Its Malonic Aciduria-associated Regulatory Role in Mitochondrial Function and Fatty Acid Oxidation. Mol Cell Proteomics. 2015 Nov;14(11):3056-71.
9	Alteration of human hepatic drug transporter activity and expression by cigarette smoke condensate. Toxicology. 2016 Jul 1;363-364:58-71.
10	Human organic anion transporters mediate the transport of tetracycline. Jpn J Pharmacol. 2002 Jan;88(1):69-76.
11	Human organic anion transporters and human organic cation transporters mediate renal antiviral transport. J Pharmacol Exp Ther. 2002 Mar;300(3):918-24.
12	Differential regulation of sinusoidal and canalicular hepatic drug transporter expression by xenobiotics activating drug-sensing receptors in primary human hepatocytes. Drug Metab Dispos. 2006 Oct;34(10):1756-63.
13	The human organic anion transporter 2 gene is transactivated by hepatocyte nuclear factor-4 alpha and suppressed by bile acids. Mol Pharmacol. 2005 May;67(5):1629-38.
14	Global molecular effects of tocilizumab therapy in rheumatoid arthritis synovium. Arthritis Rheumatol. 2014 Jan;66(1):15-23.
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16	Ethyl carbamate induces cell death through its effects on multiple metabolic pathways. Chem Biol Interact. 2017 Nov 1;277:21-32.
17	Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
18	The formation of estrogen-like tamoxifen metabolites and their influence on enzyme activity and gene expression of ADME genes. Arch Toxicol. 2018 Mar;92(3):1099-1112.
19	Omics-based responses induced by bosentan in human hepatoma HepaRG cell cultures. Arch Toxicol. 2018 Jun;92(6):1939-1952.
20	Integrative "-Omics" Analysis in Primary Human Hepatocytes Unravels Persistent Mechanisms of Cyclosporine A-Induced Cholestasis. Chem Res Toxicol. 2016 Dec 19;29(12):2164-2174.
21	Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans. Arch Toxicol. 2018 Feb;92(2):845-858.
22	KEGG: new perspectives on genomes, pathways, diseases and drugs. Nucleic Acids Res. 2017 Jan 4;45(D1):D353-D361. (dg:DG02883)
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24	Endothelial effects of emission source particles: acute toxic response gene expression profiles. Toxicol In Vitro. 2009 Feb;23(1):67-77.
25	Regulation of human hepatic drug transporter activity and expression by diesel exhaust particle extract. PLoS One. 2015 Mar 24;10(3):e0121232.
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27	Two persistent organic pollutants which act through different xenosensors (alpha-endosulfan and 2,3,7,8 tetrachlorodibenzo-p-dioxin) interact in a mixture and downregulate multiple genes involved in human hepatocyte lipid and glucose metabolism. Biochimie. 2015 Sep;116:79-91.
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29	Cellular and Molecular Effects of Prolonged Low-Level Sodium Arsenite Exposure on Human Hepatic HepaRG Cells. Toxicol Sci. 2018 Apr 1;162(2):676-687.
30	The azole fungicide tebuconazole affects human CYP1A1 and CYP1A2 expression by an aryl hydrocarbon receptor-dependent pathway. Food Chem Toxicol. 2019 Jan;123:481-491.
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